Glycolysis / Gluconeogenesis

Source	ID	Pathway
KEGG	00010

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00022	Acetaldehyde 75-07-0	acetaldehyde	C₂H₄O 44.0526
YMDB00056	Acetic acid 64-19-7	acetic acid	C₂H₄O₂ 60.052
YMDB00115	D-Glyceraldehyde 3-phosphate 142-10-9	(2-hydroxy-3-oxopropoxy)phosphonic acid	C₃H₇O₆P 170.0578
YMDB00146	Beta-D-Glucose 492-61-5	(2R,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol	C₆H₁₂O₆ 180.1559
YMDB00175	Pyruvic acid 127-17-3	2-oxopropanoic acid	C₃H₄O₃ 88.0621
YMDB00235	Oxalacetic acid 328-42-7	2-oxobutanedioic acid	C₄H₄O₅ 132.0716
YMDB00247	L-Lactic acid 79-33-4	(2R)-2-hydroxypropanoic acid	C₃H₆O₃ 90.0779
YMDB00270	Glyceric acid 1,3-biphosphate 1981-49-3	{[2-hydroxy-3-(phosphonooxy)propanoyl]oxy}phosphonic acid	C₃H₈O₁₀P₂ 266.0371
YMDB00273	Alpha-D-Glucose 492-62-6	(2S,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol	C₆H₁₂O₆ 180.1559
YMDB00276	Phosphoenolpyruvic acid 138-08-9	2-(phosphonooxy)prop-2-enoic acid	C₃H₅O₆P 168.042
YMDB00286	D-Glucose 50-99-7	(3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol	C₆H₁₂O₆ 180.1559
YMDB00288	Glucose 1-phosphate 59-56-3	{[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid	C₆H₁₃O₉P 260.1358
YMDB00311	Beta-D-Glucose 6-phosphate	{[(2R,3S,4S,5R,6R)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy}phosphonic acid	C₆H₁₃O₉P 260.1358
YMDB00312	Acetyl-CoA 72-89-9	{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₃H₃₈N₇O₁₇P₃S 809.571
YMDB00322	Dihydroxyacetone phosphate 57-04-5	(3-hydroxy-2-oxopropoxy)phosphonic acid	C₃H₇O₆P 170.0578
YMDB00381	Thiamine pyrophosphate 154-87-0	3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium	C₁₂H₁₉N₄O₇P₂S 425.314
YMDB00671	2,3-bisphospho-D-glyceric acid 138-81-8	(2R)-2,3-bis(phosphonooxy)propanoic acid	C₃H₈O₁₀P₂ 266.0371
YMDB00672	3-phospho-D-glyceroyl dihydrogen phosphate 38168-82-0	{[(2R)-2-hydroxy-3-(phosphonooxy)propanoyl]oxy}phosphonic acid	C₃H₈O₁₀P₂ 266.0371
YMDB00675	2-phospho-D-glyceric acid	(2R)-3-hydroxy-2-(phosphonooxy)propanoic acid	C₃H₇O₇P 186.0572
YMDB00756	3-phospho-D-glyceric acid 820-11-1	(2R)-2-hydroxy-3-(phosphonooxy)propanoic acid	C₃H₇O₇P 186.0572
YMDB00883	Ethanol 64-17-5	ethanol	C₂H₆O 46.0684
YMDB00947	Glucose 6-phosphate 56-73-5	{[(2R,3S,4S,5R)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy}phosphonic acid	C₆H₁₃O₉P 260.1358
YMDB00970	alpha-D-glucose 1-phosphate 59-56-3	{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid	C₆H₁₃O₉P 260.1358
YMDB00985	2-phospho-d-glycerate		C₃H₇O₇P 186.0572
YMDB01003	(S)-Lactate 79-33-4		C₃H₅O₃ 89.07
YMDB01010	acetate 71-50-1		C₂H₃O₂ 59.044
YMDB01050	phosphoenolpyruvate 138-08-9		C₃H₄O₆P 167.034
YMDB01053	pyruvate 127-17-3		C₃H₃O₃ 87.0541

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P09624	LPD1 YFL018C	Dihydrolipoyl dehydrogenase, mitochondrial	Enzyme	Glycine Coenzyme A NAD NADH Oxoglutaric acid Pyruvic acid Acetyl-CoA NAD(+) Ammonium 5,6,7,8-Tetrahydrofolic acid Succinyl-CoA S(8)-aminomethyldihydrolipoamide lipoamide S(8)-succinyldihydrolipoamide (6R)-5,10-methylenetetrahydrofolic acid hydron Dihydrolipoamide Carbon dioxide
P07246	ADH3 YMR083W	Alcohol dehydrogenase 3, mitochondrial	Enzyme	Acetaldehyde NAD Phenylacetaldehyde NADH Indoleacetaldehyde NAD(+) isobutyraldehyde 2-Methylbutanal 3-methylbutanal 2-methylbutan-1-ol isoamylol isobutanol tryptophol hydron Ethanol
P47771	ALD2 YMR170C	Aldehyde dehydrogenase [NAD(P)+] 1	Enzyme	Acetaldehyde 3-Aminopropionaldehyde Acetic acid NAD Phenylacetaldehyde NADH Beta-Alanine NAD(+) hydron water Phenylacetic acid
P46367	ALD4 YOR374W	Potassium-activated aldehyde dehydrogenase, mitochondrial	Enzyme	Acetaldehyde Coenzyme A Acetic acid NAD NADH Acetyl-CoA gamma-Aminobutyric acid Indoleacetaldehyde NAD(+) NADPH NADP indole-3-acetate 4-aminobutanal hydron water
P16467	PDC5 YLR134W	Pyruvate decarboxylase isozyme 2	Enzyme	Acetaldehyde Phenylacetaldehyde (S)-3-methyl-2-oxovaleric acid 3-(indol-3-yl)pyruvic acid Pyruvic acid Indoleacetaldehyde Alpha-Ketoisovaleric acid (R)-Acetoin isobutyraldehyde 2-Methylbutanal keto-phenylpyruvic acid hydron Carbon dioxide (4-hydroxyphenyl)pyruvic acid 3-(indol-3-yl)pyruvate 4-Hydroxyphenylacetaldehyde
P26263	PDC6 YGR087C	Pyruvate decarboxylase isozyme 3	Enzyme	Acetaldehyde (S)-2-Aceto-2-hydroxybutanoic acid 2-Ketobutyric acid Phenylacetaldehyde (S)-3-methyl-2-oxovaleric acid 3-(indol-3-yl)pyruvic acid Pyruvic acid (S)-2-Acetolactate Indoleacetaldehyde Alpha-Ketoisovaleric acid (R)-Acetoin isobutyraldehyde 2-Methylbutanal keto-phenylpyruvic acid hydron Carbon dioxide (4-hydroxyphenyl)pyruvic acid 3-(indol-3-yl)pyruvate 4-Hydroxyphenylacetaldehyde
P54114	ALD3 YMR169C	Aldehyde dehydrogenase [NAD(P)+] 2	Enzyme	Acetaldehyde 3-Aminopropionaldehyde Acetic acid NAD Phenylacetaldehyde NADH Beta-Alanine NAD(+) NADPH NADP hydron water Phenylacetic acid Glyceric acid Glyceraldehyde
P54115	ALD6 YPL061W	Magnesium-activated aldehyde dehydrogenase, cytosolic	Enzyme	Acetaldehyde Coenzyme A Acetic acid NAD NADH Acetyl-CoA Indoleacetaldehyde NADPH NADP indole-3-acetate hydron water
P00330	ADH1 YOL086C	Alcohol dehydrogenase 1	Enzyme	Acetaldehyde NAD Phenylacetaldehyde NADH Indoleacetaldehyde NAD(+) isobutyraldehyde 2-Methylbutanal 3-methylbutanal 2-methylbutan-1-ol isoamylol isobutanol tryptophol hydron Ethanol
P10127	ADH4 YGL256W	Alcohol dehydrogenase 4	Enzyme	Acetaldehyde NAD Phenylacetaldehyde NADH Indoleacetaldehyde NAD(+) isobutyraldehyde 2-Methylbutanal 3-methylbutanal 2-methylbutan-1-ol isoamylol isobutanol tryptophol hydron Ethanol
P06169	PDC1 YLR044C	Pyruvate decarboxylase isozyme 1	Enzyme	Acetaldehyde Phenylacetaldehyde (S)-3-methyl-2-oxovaleric acid 3-(indol-3-yl)pyruvic acid Pyruvic acid Indoleacetaldehyde Alpha-Ketoisovaleric acid (R)-Acetoin isobutyraldehyde 2-Methylbutanal keto-phenylpyruvic acid hydron Carbon dioxide (4-hydroxyphenyl)pyruvic acid 3-(indol-3-yl)pyruvate 4-Hydroxyphenylacetaldehyde
P38113	ADH5 YBR145W	Alcohol dehydrogenase 5	Enzyme	Acetaldehyde NAD Phenylacetaldehyde NADH Indoleacetaldehyde NAD(+) isobutyraldehyde 2-Methylbutanal 3-methylbutanal 2-methylbutan-1-ol isoamylol isobutanol tryptophol hydron Ethanol
P00331	ADH2 YMR303C	Alcohol dehydrogenase 2	Enzyme	Acetaldehyde NAD Phenylacetaldehyde NADH Indoleacetaldehyde NAD(+) isobutyraldehyde 2-Methylbutanal 3-methylbutanal 2-methylbutan-1-ol isoamylol isobutanol tryptophol hydron Ethanol
Q01574	ACS1 YAL054C	Acetyl-coenzyme A synthetase 1	Enzyme	Coenzyme A Acetic acid Adenosine monophosphate Adenosine triphosphate Pyrophosphate Acetyl-CoA propionyl-CoA propionic acid Acetyl adenylate
P52910	ACS2 YLR153C	Acetyl-coenzyme A synthetase 2	Enzyme	Coenzyme A Acetic acid Adenosine monophosphate Adenosine triphosphate Pyrophosphate Acetyl-CoA propionyl-CoA propionic acid Acetyl adenylate
P12695	PDA2 YNL071W	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	Enzyme	Coenzyme A NAD NADH Oxoglutaric acid Acetyl-CoA Succinyl-CoA hydron Carbon dioxide
P37012	PGM2 YMR105C	Phosphoglucomutase-2	Enzyme	Ribose 1-phosphate Glucose 1-phosphate Beta-D-Glucose 6-phosphate aldehydo-D-glucose 6-phosphate alpha-D-ribose 5-phosphate Glucose 6-phosphate
P33401	PGM1 YKL127W	Phosphoglucomutase-1	Enzyme	Ribose 1-phosphate Glucose 1-phosphate Beta-D-Glucose 6-phosphate aldehydo-D-glucose 6-phosphate alpha-D-ribose 5-phosphate Glucose 6-phosphate
P04807	HXK2 YGL253W	Hexokinase-2	Enzyme	D-Galactose Fructose 6-phosphate Adenosine triphosphate Mannose 6-phosphate D-Glucose aldehydo-D-glucose 6-phosphate D-fructose 1-phosphate D-Fructose hydron D-Mannose ADP Glucose 6-phosphate D-mannose 6-phosphate Beta-D-Fructose 6-phosphate
Q06204	YLR446W	Putative hexokinase YLR446W	Enzyme	D-Galactose Adenosine triphosphate Mannose 6-phosphate D-Fructose D-Mannose ADP Glucose 6-phosphate Beta-D-Fructose 6-phosphate
P04806	HXK1 YFR053C	Hexokinase-1	Enzyme	D-Galactose Fructose 6-phosphate Adenosine triphosphate Mannose 6-phosphate D-Glucose aldehydo-D-glucose 6-phosphate D-fructose 1-phosphate D-Fructose hydron D-Mannose ADP Glucose 6-phosphate D-mannose 6-phosphate Beta-D-Fructose 6-phosphate
P16861	PFK1 YGR240C	6-phosphofructokinase subunit alpha	Enzyme	Fructose 6-phosphate Fructose 1,6-bisphosphate Adenosine triphosphate D-fructose 1,6-bisphosphate hydron ADP
P16862	PFK2 YMR205C	6-phosphofructokinase subunit beta	Enzyme	Fructose 6-phosphate Fructose 1,6-bisphosphate Adenosine triphosphate D-fructose 1,6-bisphosphate ADP
P09201	FBP1 YLR377C	Fructose-1,6-bisphosphatase	Enzyme	Fructose 6-phosphate Fructose 1,6-bisphosphate D-fructose 1,6-bisphosphate water phosphate
P12709	PGI1 YBR196C	Glucose-6-phosphate isomerase	Enzyme	Fructose 6-phosphate Beta-D-Glucose 6-phosphate aldehydo-D-glucose 6-phosphate Glucose 6-phosphate Beta-D-Fructose 6-phosphate β-D-fructofuranose 6-phosphate
P14540	FBA1 YKL060C	Fructose-bisphosphate aldolase	Enzyme	Fructose 1,6-bisphosphate D-Glyceraldehyde 3-phosphate D-Erythrose 4-phosphate Dihydroxyacetone phosphate D-glyceraldehyde D-fructose 1-phosphate D-fructose 1,6-bisphosphate sedoheptulose 1,7-bisphosphate
P00549	PYK1 YAL038W	Pyruvate kinase 1	Enzyme	Adenosine triphosphate Pyruvic acid Phosphoenolpyruvic acid hydron ADP
P52489	PYK2 YOR347C	Pyruvate kinase 2	Enzyme	Adenosine triphosphate Pyruvic acid Phosphoenolpyruvic acid hydron ADP
Q04409	EMI2 YDR516C	Putative glucokinase-2	Enzyme	Adenosine triphosphate Beta-D-Glucose Mannose 6-phosphate Alpha-D-Glucose D-Glucose Beta-D-Glucose 6-phosphate D-Fructose hydron D-Mannose ADP Glucose 6-phosphate Beta-D-Fructose 6-phosphate
P10963	PCK1 YKR097W	Phosphoenolpyruvate carboxykinase [ATP]	Enzyme	Adenosine triphosphate Oxalacetic acid Phosphoenolpyruvic acid Carbon dioxide ADP
P17709	GLK1 YCL040W	Glucokinase-1	Enzyme	Adenosine triphosphate Mannose 6-phosphate D-Glucose Beta-D-Glucose 6-phosphate aldehydo-D-glucose 6-phosphate D-Fructose hydron D-Mannose ADP Glucose 6-phosphate Beta-D-Fructose 6-phosphate
P00560	PGK1 YCR012W	Phosphoglycerate kinase	Enzyme	Adenosine triphosphate Glyceric acid 1,3-biphosphate 3-Phosphoglyceric acid 3-phospho-D-glyceroyl dihydrogen phosphate 3-phospho-D-glyceric acid ADP
P00360	TDH1 YJL052W	Glyceraldehyde-3-phosphate dehydrogenase 1	Enzyme	NAD D-Glyceraldehyde 3-phosphate NADH D-Erythrose 4-phosphate Glyceric acid 1,3-biphosphate NAD(+) 3-phospho-D-glyceroyl dihydrogen phosphate hydron water phosphate Phosphoric acid 4-Phospho-D-erythronate
P00358	TDH2 YJR009C	Glyceraldehyde-3-phosphate dehydrogenase 2	Enzyme	NAD D-Glyceraldehyde 3-phosphate NADH Glyceric acid 1,3-biphosphate NAD(+) 3-phospho-D-glyceroyl dihydrogen phosphate hydron phosphate
P22281	ALD1	Aldehyde dehydrogenase 1, mitochondrial	Enzyme	NAD NADH
P00359	TDH3 YGR192C	Glyceraldehyde-3-phosphate dehydrogenase 3	Enzyme	NAD D-Glyceraldehyde 3-phosphate NADH Glyceric acid 1,3-biphosphate NAD(+) 3-phospho-D-glyceroyl dihydrogen phosphate hydron phosphate
P00942	TPI1 YDR050C	Triosephosphate isomerase	Enzyme	D-Glyceraldehyde 3-phosphate Dihydroxyacetone phosphate
P25377	ADH7 YCR105W	NADP-dependent alcohol dehydrogenase 7	Enzyme	Acetaldehyde NAD Phenylacetaldehyde NADH Glycerol Indoleacetaldehyde NADPH NADP isobutyraldehyde 2-Methylbutanal 3-methylbutanal 2-methylbutan-1-ol isoamylol isobutanol tryptophol hydron Ethanol 2-phenylethanol Tyrosol Glyceraldehyde
Q04894	ADH6 YMR318C	NADP-dependent alcohol dehydrogenase 6	Enzyme	Acetaldehyde NAD Phenylacetaldehyde NADH L-Threonine Glycerol Indoleacetaldehyde NADPH NADP isobutyraldehyde 2-Methylbutanal 3-methylbutanal 2-methylbutan-1-ol isoamylol isobutanol tryptophol L-2-amino-3-oxobutanoic acid hydron Ethanol 2-phenylethanol
P04397	GAL10 YBR019C	Bifunctional protein GAL10	Enzyme	D-Galactose Beta-D-Glucose Uridine diphosphate glucose Alpha-D-Glucose UDP-D-glucose UDP-D-galactose udp-galactose Beta-D-Galactose
P16387	PDA1 YER178W	Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial	Enzyme	Pyruvic acid (6R)-5,10-Methenyltetrahydrofolic acid 5-Formyltetrahydrofolic acid hydron water Carbon dioxide
P32473	PDB1 YBR221C	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	Enzyme	Coenzyme A NAD NADH Pyruvic acid Acetyl-CoA Thiamine pyrophosphate Carbon dioxide 2-(a-Hydroxyethyl)thiamine diphosphate
Q03161	YMR099C	Glucose-6-phosphate 1-epimerase	Enzyme	Beta-D-Glucose 6-phosphate Glucose 6-phosphate
Q03262	YMR278W	Phosphoglucomutase YMR278W	Enzyme	Glyceric acid 1,3-biphosphate Glucose 1-phosphate 3-Phosphoglyceric acid Glucose 6-phosphate Alpha-D-Glucose 1,6-bisphosphate
Q12007	ERR1 YOR393W	Enolase-related protein 1/2	Enzyme	Phosphoenolpyruvic acid 2-phospho-D-glyceric acid water 2-phospho-d-glycerate
P42222	ERR3 YMR323W	Enolase-related protein 3	Enzyme	Phosphoenolpyruvic acid 2-phospho-D-glyceric acid water 2-phospho-d-glycerate
P00924	ENO1 YGR254W	Enolase 1	Enzyme	Phosphoenolpyruvic acid 2-phospho-D-glyceric acid water 2-phospho-d-glycerate
P00925	ENO2 YHR174W	Enolase 2	Enzyme	Phosphoenolpyruvic acid 2-phospho-D-glyceric acid water 2-phospho-d-glycerate
P00950	GPM1 YKL152C	Phosphoglycerate mutase 1	Enzyme	3-Phosphoglyceric acid 2,3-bisphospho-D-glyceric acid 3-phospho-D-glyceroyl dihydrogen phosphate 2-phospho-D-glyceric acid 3-phospho-D-glyceric acid hydron 2-phospho-d-glycerate
Q99288	DET1 YDR051C	Putative phosphoglycerate mutase DET1	Enzyme	3-Phosphoglyceric acid 2,3-bisphospho-D-glyceric acid 2-phospho-D-glyceric acid 3-phospho-D-glyceric acid 2-phospho-d-glycerate
Q12040	YOR283W	Probable phosphoglycerate mutase YOR283W	Enzyme	3-Phosphoglyceric acid 2,3-bisphospho-D-glyceric acid 2-phospho-D-glyceric acid 3-phospho-D-glyceric acid water phosphate 2-phospho-d-glycerate
Q12326	GPM3 YOL056W	Phosphoglycerate mutase 3	Enzyme	3-Phosphoglyceric acid 2,3-bisphospho-D-glyceric acid 2-phospho-D-glyceric acid 3-phospho-D-glyceric acid 2-phospho-d-glycerate
Q12008	GPM2 YDL021W	Phosphoglycerate mutase 2	Enzyme	Glyceric acid 1,3-biphosphate 3-Phosphoglyceric acid 2,3-bisphospho-D-glyceric acid 2-phospho-D-glyceric acid 3-phospho-D-glyceric acid water phosphate 2-phospho-d-glycerate