Acetyl-CoA (YMDB00312)

General function:

Involved in oxidoreductase activity

Specific function:

Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine

Gene Name:

LPD1

Uniprot ID:

P09624

Molecular weight:

54009.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(+) + H(2)O = an acid + NADH

Gene Name:

ALD4

Uniprot ID:

P46367

Molecular weight:

56723.19922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(+) + H(2)O = an acid + NADH

Gene Name:

ALD6

Uniprot ID:

P54115

Molecular weight:

54413.69922

Reactions

General function:

Involved in glutamate N-acetyltransferase activity

Specific function:

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis:the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate

Gene Name:

ARG7

Uniprot ID:

Q04728

Molecular weight:

47848.30078

Reactions

General function:

Involved in catalytic activity

Specific function:

This isozyme is necessary for growth on acetate as sole C-source

Gene Name:

MLS1

Uniprot ID:

P30952

Molecular weight:

62790.60156

Reactions

General function:

Involved in catalytic activity

Specific function:

This isozyme is involved in the degradation of allantoin (purine catabolism)

Gene Name:

DAL7

Uniprot ID:

P21826

Molecular weight:

62793.39844

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate

Gene Name:

GNA1

Uniprot ID:

P43577

Molecular weight:

18134.80078

Reactions

General function:

Involved in O-acetyltransferase activity

Specific function:

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L- homoserine

Gene Name:

MET2

Uniprot ID:

P08465

Molecular weight:

53659.0

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2- hydroxybutane-1,2,4-tricarboxylate + CoA

Gene Name:

LYS21

Uniprot ID:

Q12122

Molecular weight:

48593.80078

Reactions

General function:

Involved in 2-isopropylmalate synthase activity

Specific function:

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Redundant to LEU4, responsible of about 20% of alpha-IPMS activity. Involved in leucine synthesis

Gene Name:

LEU9

Uniprot ID:

Q12166

Molecular weight:

67199.60156

Reactions

General function:

Involved in peptide alpha-N-acetyltransferase activity

Specific function:

N-terminal acetylation of proteins. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. NAT2 acts on proteins with a N-terminal methionine

Gene Name:

NAT2

Uniprot ID:

P37293

Molecular weight:

32804.19922

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

Catalyzes the formation of acetoacetyl-CoA in the biosynthesis of mevalonate, an intermediate required for the biosynthesis of sterols and nonsterol isoprenoids

Gene Name:

ERG10

Uniprot ID:

P41338

Molecular weight:

41728.39844

Reactions

General function:

Involved in acyltransferase activity

Specific function:

Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria

Gene Name:

CAT2

Uniprot ID:

P32796

Molecular weight:

77241.20313

Reactions

General function:

Transcription

Specific function:

Component of the NatC N-terminal acetyltransferase, which catalyzes acetylation of the N-terminus Met of L-A virus Gag protein. MAK31 is necessary for the structural stability of L-A double-stranded RNA-containing particles. Necessary for growth at 37 degrees Celsius as well as for maintenance of the killer plasmid

Gene Name:

MAK31

Uniprot ID:

P23059

Molecular weight:

9724.5

General function:

Involved in acyltransferase activity

Specific function:

Involved in the transfer of acetyl-CoA into mitochondria. May also be involved in the metabolism of acetate and of ethanol

Gene Name:

YAT1

Uniprot ID:

P80235

Molecular weight:

77764.79688

Reactions

General function:

Involved in catalytic activity

Specific function:

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation. It may be involved in overall regulation of acetylation during melatonin synthesis

Gene Name:

ACH1

Uniprot ID:

P32316

Molecular weight:

58711.5

Reactions

General function:

Involved in transferase activity, transferring nitrogenous groups

Specific function:

Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine

Gene Name:

LCB1

Uniprot ID:

P25045

Molecular weight:

62206.60156

Reactions

General function:

Involved in acyl-CoA dehydrogenase activity

Specific function:

Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2)

Gene Name:

POX1

Uniprot ID:

P13711

Molecular weight:

84041.39844

Reactions

General function:

Involved in hydroxymethylglutaryl-CoA synthase activity

Specific function:

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase

Gene Name:

ERG13

Uniprot ID:

P54839

Molecular weight:

55013.10156

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

Catalytic component of the NatC N-terminal acetyltransferase, which catalyzes acetylation of the N-terminus Met of L-A virus Gag protein

Gene Name:

MAK3

Uniprot ID:

Q03503

Molecular weight:

20456.59961

Reactions

General function:

Involved in 2-isopropylmalate synthase activity

Specific function:

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)

Gene Name:

LEU4

Uniprot ID:

P06208

Molecular weight:

68408.29688

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification

Gene Name:

EHT1

Uniprot ID:

P38295

Molecular weight:

51254.80078

Reactions

General function:

Involved in acetate-CoA ligase activity

Specific function:

Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Aerobic" isozyme of acetyl-coenzyme A synthetase, which supports growth on nonfermentable carbon sources such as glycerol and ethanol. May be required for assimilation of ethanol and acetate

Gene Name:

ACS1

Uniprot ID:

Q01574

Molecular weight:

79140.10156

Reactions

General function:

Involved in acyl carrier activity

Specific function:

Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Gene Name:

ACP1

Uniprot ID:

P32463

Molecular weight:

13942.5

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2- hydroxybutane-1,2,4-tricarboxylate + CoA

Gene Name:

LYS20

Uniprot ID:

P48570

Molecular weight:

47098.39844

Reactions

General function:

Involved in acetate-CoA ligase activity

Specific function:

Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Anaerobic" isozyme of acetyl-coenzyme A synthetase, which is required for growth on fermentable carbon sources such as glucose. May be involved in the PDH (pyruvate dehydrogenase complex) bypass

Gene Name:

ACS2

Uniprot ID:

P52910

Molecular weight:

75491.10156

Reactions

General function:

Involved in alcohol O-acetyltransferase activity

Specific function:

Catalyzes the esterification of isoamyl alcohol and various other alcohols by acetyl-CoA

Gene Name:

ATF1

Uniprot ID:

P40353

Molecular weight:

61035.5

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

Gene Name:

POT1

Uniprot ID:

P27796

Molecular weight:

44729.89844

Reactions

General function:

Involved in transferase activity

Specific function:

Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for:[acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase

Gene Name:

FAS1

Uniprot ID:

P07149

Molecular weight:

228689.0

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for:acyl carrier protein, 3- oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl- carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex

Gene Name:

FAS2

Uniprot ID:

P19097

Molecular weight:

206945.0

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

CIT3

Uniprot ID:

P43635

Molecular weight:

53810.69922

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification

Gene Name:

EEB1

Uniprot ID:

Q02891

Molecular weight:

51723.19922

Reactions

General function:

Involved in alcohol O-acetyltransferase activity

Specific function:

Acetyl-CoA + an alcohol = CoA + an acetyl ester

Gene Name:

ATF2

Uniprot ID:

P53296

Molecular weight:

61897.5

Reactions

General function:

Involved in acyltransferase activity

Specific function:

Involved in the shutteling of acetyl-CoA in the cell

Gene Name:

YAT2

Uniprot ID:

P40017

Molecular weight:

103333.0

Reactions

General function:

Involved in acyltransferase activity

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)

Gene Name:

PDA2

Uniprot ID:

P12695

Molecular weight:

51817.5

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

CIT2

Uniprot ID:

P08679

Molecular weight:

51412.89844

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

CIT1

Uniprot ID:

P00890

Molecular weight:

53359.60156

Reactions

General function:

Involved in arginine biosynthetic process

Specific function:

N-acetylglutamate synthase involved in arginine biosynthesis

Gene Name:

ARG2

Uniprot ID:

P40360

Molecular weight:

65609.5

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

Acts as catalytic subunit of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling. It acetylates histones H3, preferentially at 'Lys-14', and H4, preferentially at 'Lys-8'. It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitiviy to Pichia inositovora toxin. May be involved in tRNA modification. ELP3 is required for the complex integrity and for the association of the complex with nascent RNA transcript. Independently, ELP3 may be involved in polarized exocytosis. Is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA

Gene Name:

ELP3

Uniprot ID:

Q02908

Molecular weight:

63656.5

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Maintains high levels of reduced glutathione in the cytosol

Gene Name:

GLR1

Uniprot ID:

P41921

Molecular weight:

53440.60156

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

Catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover

Gene Name:

ARD1

Uniprot ID:

P07347

Molecular weight:

27602.90039

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Catalyzes the rate-limiting reaction in the mitochondrial fatty acid synthesis (FAS) type II pathway. Responsible for the production of the mitochondrial malonyl-CoA, used for the biosynthesis of the cofactor lipoic acid. This protein carries three functions:biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase

Gene Name:

HFA1

Uniprot ID:

P32874

Molecular weight:

259161.0

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase

Gene Name:

FAS3

Uniprot ID:

Q00955

Molecular weight:

250351.0

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

N-acetyltransferase whose physiological acetyl acceptor substrate is still unknown. In vitro, histone acetylation is very weak

Gene Name:

HPA3

Uniprot ID:

P39979

Molecular weight:

20698.5

Reactions

General function:

Involved in catalytic activity

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)

Gene Name:

PDB1

Uniprot ID:

P32473

Molecular weight:

40053.19922

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino- terminal methionine residues of all proteins beginning with Met- Asp or Met-Glu and of some proteins beginning with Met-Asn or Met- Met. NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions

Gene Name:

NAT3

Uniprot ID:

Q06504

Molecular weight:

22921.0

Reactions