Coenzyme A (YMDB00045)

General function:

Involved in 5-aminolevulinate synthase activity

Specific function:

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2)

Gene Name:

HEM1

Uniprot ID:

P09950

Molecular weight:

59361.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine

Gene Name:

LPD1

Uniprot ID:

P09624

Molecular weight:

54009.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(+) + H(2)O = an acid + NADH

Gene Name:

ALD4

Uniprot ID:

P46367

Molecular weight:

56723.19922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(+) + H(2)O = an acid + NADH

Gene Name:

ALD6

Uniprot ID:

P54115

Molecular weight:

54413.69922

Reactions

General function:

Involved in glutamate N-acetyltransferase activity

Specific function:

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis:the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate

Gene Name:

ARG7

Uniprot ID:

Q04728

Molecular weight:

47848.30078

Reactions

General function:

Involved in catalytic activity

Specific function:

This isozyme is necessary for growth on acetate as sole C-source

Gene Name:

MLS1

Uniprot ID:

P30952

Molecular weight:

62790.60156

Reactions

General function:

Involved in catalytic activity

Specific function:

This isozyme is involved in the degradation of allantoin (purine catabolism)

Gene Name:

DAL7

Uniprot ID:

P21826

Molecular weight:

62793.39844

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate

Gene Name:

GNA1

Uniprot ID:

P43577

Molecular weight:

18134.80078

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

LSC1

Uniprot ID:

P53598

Molecular weight:

35032.19922

Reactions

General function:

Involved in O-acetyltransferase activity

Specific function:

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L- homoserine

Gene Name:

MET2

Uniprot ID:

P08465

Molecular weight:

53659.0

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2- hydroxybutane-1,2,4-tricarboxylate + CoA

Gene Name:

LYS21

Uniprot ID:

Q12122

Molecular weight:

48593.80078

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis. May be involved in lipid particle synthesis from the endoplasmic reticulum and ergosterol biosynthesis

Gene Name:

DGA1

Uniprot ID:

Q08650

Molecular weight:

47710.89844

Reactions

General function:

Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Specific function:

Catalyzes the conversion of dihydroceramide and also phytoceramide to dihydrosphingosine or phytosphingosine. Prefers dihydroceramide. Very low reverse hydrolysis activity, catalyzing synthesis of dihydroceramide from fatty acid and dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide. May play a role in heat stress response

Gene Name:

YDC1

Uniprot ID:

Q02896

Molecular weight:

37230.5

Reactions

General function:

Involved in catalytic activity

Specific function:

Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Contributes, with FAA1, to the activation of imported myristate

Gene Name:

FAA4

Uniprot ID:

P47912

Molecular weight:

77266.5

Reactions

General function:

Involved in 1-acylglycerol-3-phosphate O-acyltransferas

Specific function:

Lysophosphatidic acid acyltransferase involved in membrane remodeling leading to increased organic solvent tolerance. Involved in resistance to azoles and copper

Gene Name:

ICT1

Uniprot ID:

Q12385

Molecular weight:

45140.39844

Reactions

General function:

Involved in 2-isopropylmalate synthase activity

Specific function:

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Redundant to LEU4, responsible of about 20% of alpha-IPMS activity. Involved in leucine synthesis

Gene Name:

LEU9

Uniprot ID:

Q12166

Molecular weight:

67199.60156

Reactions

General function:

Involved in peptide alpha-N-acetyltransferase activity

Specific function:

N-terminal acetylation of proteins. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. NAT2 acts on proteins with a N-terminal methionine

Gene Name:

NAT2

Uniprot ID:

P37293

Molecular weight:

32804.19922

Reactions

General function:

Involved in acyltransferase activity

Specific function:

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

KGD2

Uniprot ID:

P19262

Molecular weight:

50430.30078

Reactions

General function:

Involved in fatty acid elongase activity

Specific function:

Involved in synthesis of 1,3-beta-glucan. Could be a subunit of 1,3-beta-glucan synthase. Could be also a component of the membrane bound fatty acid elongation systems that produce the 26-carbon very long chain fatty acids that are precursors for ceramide and sphingolipids. Appears to be involved in the elongation of fatty acids up to 24 carbons. Appears to have the highest affinity for substrates with chain length less than 22 carbons

Gene Name:

FEN1

Uniprot ID:

P25358

Molecular weight:

40001.80078

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

Catalyzes the formation of acetoacetyl-CoA in the biosynthesis of mevalonate, an intermediate required for the biosynthesis of sterols and nonsterol isoprenoids

Gene Name:

ERG10

Uniprot ID:

P41338

Molecular weight:

41728.39844

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA. Has an indirect role in endocytic membrane trafficking. May have a function in protein biosynthesis in mitochondrial small ribosomal subunit

Gene Name:

EHD3

Uniprot ID:

P28817

Molecular weight:

56287.89844

Reactions

General function:

Involved in acyltransferase activity

Specific function:

Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria

Gene Name:

CAT2

Uniprot ID:

P32796

Molecular weight:

77241.20313

Reactions

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI- anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins

Gene Name:

GWT1

Uniprot ID:

P47026

Molecular weight:

55465.60156

Reactions

General function:

Transcription

Specific function:

Component of the NatC N-terminal acetyltransferase, which catalyzes acetylation of the N-terminus Met of L-A virus Gag protein. MAK31 is necessary for the structural stability of L-A double-stranded RNA-containing particles. Necessary for growth at 37 degrees Celsius as well as for maintenance of the killer plasmid

Gene Name:

MAK31

Uniprot ID:

P23059

Molecular weight:

9724.5

General function:

Involved in acyltransferase activity

Specific function:

Involved in the transfer of acetyl-CoA into mitochondria. May also be involved in the metabolism of acetate and of ethanol

Gene Name:

YAT1

Uniprot ID:

P80235

Molecular weight:

77764.79688

Reactions

General function:

Involved in catalytic activity

Specific function:

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation. It may be involved in overall regulation of acetylation during melatonin synthesis

Gene Name:

ACH1

Uniprot ID:

P32316

Molecular weight:

58711.5

Reactions

General function:

Involved in hydroxymethylglutaryl-CoA reductase (NADPH) activity

Specific function:

This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of the sterol biosynthesis

Gene Name:

HMG1

Uniprot ID:

P12683

Molecular weight:

115624.0

Reactions

General function:

Involved in hydroxymethylglutaryl-CoA reductase (NADPH) activity

Specific function:

This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of the sterol biosynthesis

Gene Name:

HMG2

Uniprot ID:

P12684

Molecular weight:

115691.0

Reactions

General function:

Involved in transferase activity, transferring nitrogenous groups

Specific function:

Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine

Gene Name:

LCB1

Uniprot ID:

P25045

Molecular weight:

62206.60156

Reactions

General function:

Involved in acyl-CoA dehydrogenase activity

Specific function:

Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2)

Gene Name:

POX1

Uniprot ID:

P13711

Molecular weight:

84041.39844

Reactions

General function:

Involved in hydroxymethylglutaryl-CoA synthase activity

Specific function:

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase

Gene Name:

ERG13

Uniprot ID:

P54839

Molecular weight:

55013.10156

Reactions

General function:

Involved in catalytic activity

Specific function:

Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It may supplement intracellular myristoyl-CoA pools from exogenous myristate. Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities

Gene Name:

FAA1

Uniprot ID:

P30624

Molecular weight:

77865.79688

Reactions

General function:

Involved in dephospho-CoA kinase activity

Specific function:

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

Gene Name:

CAB5

Uniprot ID:

Q03941

Molecular weight:

27339.5

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

Catalytic component of the NatC N-terminal acetyltransferase, which catalyzes acetylation of the N-terminus Met of L-A virus Gag protein

Gene Name:

MAK3

Uniprot ID:

Q03503

Molecular weight:

20456.59961

Reactions

General function:

Involved in catalytic activity

Specific function:

Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. This enzyme acts preferentially on C16 and C18 fatty acids with a cis-double bond at C-9-C-10

Gene Name:

FAA3

Uniprot ID:

P39002

Molecular weight:

77946.0

Reactions

General function:

Involved in protein binding

Specific function:

Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAC1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Deletion of LAG1 results in a pronounced increase (approximately 50%) in mean and in maximum life span

Gene Name:

LAG1

Uniprot ID:

P38703

Molecular weight:

48454.10156

Reactions

General function:

Involved in 2-isopropylmalate synthase activity

Specific function:

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)

Gene Name:

LEU4

Uniprot ID:

P06208

Molecular weight:

68408.29688

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification

Gene Name:

EHT1

Uniprot ID:

P38295

Molecular weight:

51254.80078

Reactions

General function:

Involved in fatty acid elongase activity

Specific function:

May be a membrane bound enzyme involved in the highly specific elongation of saturated 14-carbon fatty acids (14:0) to 16-carbon species (16:0)

Gene Name:

ELO1

Uniprot ID:

P39540

Molecular weight:

36233.60156

Reactions

General function:

Involved in acyltransferase activity

Specific function:

May be an acyltransferase with an altered substrate specificity that enables it to use a C-26-CoA in place of the C-16 or C-18-CoAs used by the wild-type protein

Gene Name:

SLC1

Uniprot ID:

P33333

Molecular weight:

33886.69922

Reactions

General function:

Involved in acetate-CoA ligase activity

Specific function:

Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Aerobic" isozyme of acetyl-coenzyme A synthetase, which supports growth on nonfermentable carbon sources such as glycerol and ethanol. May be required for assimilation of ethanol and acetate

Gene Name:

ACS1

Uniprot ID:

Q01574

Molecular weight:

79140.10156

Reactions

General function:

Involved in acyl carrier activity

Specific function:

Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Gene Name:

ACP1

Uniprot ID:

P32463

Molecular weight:

13942.5

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2- hydroxybutane-1,2,4-tricarboxylate + CoA

Gene Name:

LYS20

Uniprot ID:

P48570

Molecular weight:

47098.39844

Reactions

General function:

Involved in acetate-CoA ligase activity

Specific function:

Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Anaerobic" isozyme of acetyl-coenzyme A synthetase, which is required for growth on fermentable carbon sources such as glucose. May be involved in the PDH (pyruvate dehydrogenase complex) bypass

Gene Name:

ACS2

Uniprot ID:

P52910

Molecular weight:

75491.10156

Reactions

General function:

Involved in acyltransferase activity

Specific function:

Acyltransferase which mediates the conversion of 1-acyl- sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a broad LPC fatty acyl chain substrate specificity utilizing LPC molecules ranging in length from C-10 to C-20. Does not utilize other lysolipids than LPC as acceptor. Also shows acyl-CoA-independent acyltransferase activity. Required for normal phospholipid content of mitochondrial membranes. Involved in the remodeling of the acyl groups of cardiolipin in the mitochondrial inner membrane, which affects the assembly and stability of respiratory chain complex IV and its supercomplex forms

Gene Name:

TAZ1

Uniprot ID:

Q06510

Molecular weight:

44187.19922

Reactions

General function:

Involved in catalytic activity

Specific function:

Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Preferentially acts on C9:0-C13:0 fatty acids although C7:0-C17:0 fatty acids are tolerated

Gene Name:

FAA2

Uniprot ID:

P39518

Molecular weight:

83437.10156

Reactions

General function:

Involved in alcohol O-acetyltransferase activity

Specific function:

Catalyzes the esterification of isoamyl alcohol and various other alcohols by acetyl-CoA

Gene Name:

ATF1

Uniprot ID:

P40353

Molecular weight:

61035.5

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

Gene Name:

POT1

Uniprot ID:

P27796

Molecular weight:

44729.89844

Reactions

General function:

Involved in transferase activity

Specific function:

Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for:[acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase

Gene Name:

FAS1

Uniprot ID:

P07149

Molecular weight:

228689.0

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for:acyl carrier protein, 3- oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl- carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex

Gene Name:

FAS2

Uniprot ID:

P19097

Molecular weight:

206945.0

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

CIT3

Uniprot ID:

P43635

Molecular weight:

53810.69922

Reactions

General function:

Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Specific function:

Hydrolyzes phytoceramide and also dihydroceramide into phytosphingosine or dihydrosphingosine. Prefers phytoceramide. Has also reverse hydrolysis activity, catalyzing synthesis of phytoceramide and dihydroceramide from palmitic acid and phytosphingosine or dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide

Gene Name:

YPC1

Uniprot ID:

P38298

Molecular weight:

36419.39844

Reactions

General function:

Involved in transferase activity

Specific function:

Catalytic subunit of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine

Gene Name:

LCB2

Uniprot ID:

P40970

Molecular weight:

63110.19922

Reactions

General function:

Involved in acyltransferase activity

Specific function:

G-3-P/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase

Gene Name:

GPT1

Uniprot ID:

P32784

Molecular weight:

85693.5

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of mitochondrial acyl-carrier-protein

Gene Name:

PPT2

Uniprot ID:

Q12036

Molecular weight:

19973.0

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification

Gene Name:

EEB1

Uniprot ID:

Q02891

Molecular weight:

51723.19922

Reactions

General function:

Involved in identical protein binding

Specific function:

Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAG1. Facilitates ER-to-Golgi transport of GPI-anchored proteins

Gene Name:

LAC1

Uniprot ID:

P28496

Molecular weight:

48991.60156

Reactions

General function:

Involved in alcohol O-acetyltransferase activity

Specific function:

Acetyl-CoA + an alcohol = CoA + an acetyl ester

Gene Name:

ATF2

Uniprot ID:

P53296

Molecular weight:

61897.5

Reactions

General function:

Involved in acyltransferase activity

Specific function:

Involved in the shutteling of acetyl-CoA in the cell

Gene Name:

YAT2

Uniprot ID:

P40017

Molecular weight:

103333.0

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

LSC2

Uniprot ID:

P53312

Molecular weight:

46900.30078

Reactions

General function:

Involved in O-acyltransferase activity

Specific function:

Ensures probably most of the acyltransferase activity. Suppression of ARE2 reduces sterol ester levels to 25% of the normal value

Gene Name:

ARE2

Uniprot ID:

P53629

Molecular weight:

74022.20313

Reactions

General function:

Involved in acyltransferase activity

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)

Gene Name:

PDA2

Uniprot ID:

P12695

Molecular weight:

51817.5

Reactions

General function:

Involved in acyl-CoA thioesterase activity

Specific function:

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH

Gene Name:

TES1

Uniprot ID:

P41903

Molecular weight:

40259.39844

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

CIT2

Uniprot ID:

P08679

Molecular weight:

51412.89844

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

CIT1

Uniprot ID:

P00890

Molecular weight:

53359.60156

Reactions

General function:

Involved in arginine biosynthetic process

Specific function:

N-acetylglutamate synthase involved in arginine biosynthesis

Gene Name:

ARG2

Uniprot ID:

P40360

Molecular weight:

65609.5

Reactions

General function:

Involved in O-acyltransferase activity

Specific function:

Acyl-CoA + cholesterol = CoA + cholesterol ester

Gene Name:

ARE1

Uniprot ID:

P25628

Molecular weight:

71612.5

Reactions

General function:

Involved in glycylpeptide N-tetradecanoyltransferase activity

Specific function:

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N- terminal glycine in the nascent polypeptide substrates. Uncharged amino acids are preferred at position 2 while neutral residues are favored at positions 3 and 4. Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6

Gene Name:

NMT1

Uniprot ID:

P14743

Molecular weight:

52837.10156

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

Acts as catalytic subunit of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling. It acetylates histones H3, preferentially at 'Lys-14', and H4, preferentially at 'Lys-8'. It functions as a gamma-toxin target (TOT); disruption of the complex confers resistance to Kluyveromyces lactis toxin zymocin (pGKL1 killer toxin). May also be involved in sensitiviy to Pichia inositovora toxin. May be involved in tRNA modification. ELP3 is required for the complex integrity and for the association of the complex with nascent RNA transcript. Independently, ELP3 may be involved in polarized exocytosis. Is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA

Gene Name:

ELP3

Uniprot ID:

Q02908

Molecular weight:

63656.5

Reactions

General function:

Involved in acyltransferase activity

Specific function:

G-3-P/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase

Gene Name:

GPT2

Uniprot ID:

P36148

Molecular weight:

83644.0

Reactions

General function:

Involved in 1-acylglycerol-3-phosphate O-acyltransferas

Specific function:

Membrane-bound O-acyltransferase that mediates the incorporation of unsaturated acyl chains into the sn-2 position of phopholipids. Preferentially acylates lysophosphocholine, but also lysophosphoethanolamine and lysophosphatidylglycerol

Gene Name:

ALE1

Uniprot ID:

Q08548

Molecular weight:

72227.39844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Maintains high levels of reduced glutathione in the cytosol

Gene Name:

GLR1

Uniprot ID:

P41921

Molecular weight:

53440.60156

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

Catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover

Gene Name:

ARD1

Uniprot ID:

P07347

Molecular weight:

27602.90039

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

N-acetyltransferase whose physiological acetyl acceptor substrate is still unknown. In vitro, histone acetylation is very weak

Gene Name:

HPA3

Uniprot ID:

P39979

Molecular weight:

20698.5

Reactions

General function:

Involved in oxoglutarate dehydrogenase (succinyl-transferring) activity

Specific function:

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

KGD1

Uniprot ID:

P20967

Molecular weight:

114416.0

Reactions

General function:

Involved in catalytic activity

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)

Gene Name:

PDB1

Uniprot ID:

P32473

Molecular weight:

40053.19922

Reactions

General function:

Involved in metabolic process

Specific function:

Releases specific fatty acids from neutral lipid triacylglycerols (TAG) thereby supplying fatty acids to a general acylation process. May have a specific role in sporulation

Gene Name:

TGL5

Uniprot ID:

Q12043

Molecular weight:

84715.10156

Reactions

General function:

Involved in metabolic process

Specific function:

Releases specific fatty acids from neutral lipid triacylglycerols (TAG) thereby supplying fatty acids to a general acylation process. May have a specific role in sporulation

Gene Name:

TGL4

Uniprot ID:

P36165

Molecular weight:

102716.0

Reactions

General function:

Involved in transferase activity

Specific function:

Involved in biosynthesis of fatty acids in mitochondria

Gene Name:

MCT1

Uniprot ID:

Q12283

Molecular weight:

40706.89844

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino- terminal methionine residues of all proteins beginning with Met- Asp or Met-Glu and of some proteins beginning with Met-Asn or Met- Met. NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions

Gene Name:

NAT3

Uniprot ID:

Q06504

Molecular weight:

22921.0

Reactions

General function:

lipid particle organization

Specific function:

Acyl-CoA-dependent lysophosphatidic acid acyltransferase with preference for oleoyl-CoA. Involved in triacylglyceride homeostasis and lipid droplet formation. Involved in vacuolar protein sorting.

Gene Name:

LOA1

Uniprot ID:

Q06508

Molecular weight:

33815.635

Reactions