hydron (YMDB00862)

General function:

Involved in adenosine kinase activity

Specific function:

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. ADO1 does not play a major role in adenine utilization in yeast. Its physiological role could primarily be to recycle adenosine produced by the methyl cycle

Gene Name:

ADO1

Uniprot ID:

P47143

Molecular weight:

36372.0

Reactions

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. It is required for spore germination. Has an essential role in cellular metabolism

Gene Name:

SEC59

Uniprot ID:

P20048

Molecular weight:

58905.39844

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate

Gene Name:

ADE6

Uniprot ID:

P38972

Molecular weight:

148904.0

Reactions

General function:

Involved in hydroxymethyl-, formyl- and related transferase activity

Specific function:

10-formyltetrahydrofolate + N(1)-(5-phospho-D- ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide

Gene Name:

ADE8

Uniprot ID:

P04161

Molecular weight:

23540.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate

Gene Name:

TRP3

Uniprot ID:

P00937

Molecular weight:

53488.89844

Reactions

General function:

Involved in catalytic activity

Specific function:

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutamine amidotransferase domain provides the ammonia necessary to the cyclase domain to produce IGP and AICAR from PRFAR

Gene Name:

HIS7

Uniprot ID:

P33734

Molecular weight:

61067.60156

Reactions

General function:

Involved in carboxyl- or carbamoyltransferase activity

Specific function:

This protein is a "fusion" protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase)

Gene Name:

URA2

Uniprot ID:

P07259

Molecular weight:

245124.0

Reactions

General function:

Involved in ATP binding

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

CPA2

Uniprot ID:

P03965

Molecular weight:

123914.0

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

Gene Name:

URA7

Uniprot ID:

P28274

Molecular weight:

64709.80078

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

Gene Name:

GLN1

Uniprot ID:

P32288

Molecular weight:

41705.60156

Reactions

General function:

Involved in biosynthetic process

Specific function:

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate

Gene Name:

TRP2

Uniprot ID:

P00899

Molecular weight:

56767.0

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate

Gene Name:

GUA1

Uniprot ID:

P38625

Molecular weight:

58481.80078

Reactions

General function:

Involved in asparagine synthase (glutamine-hydrolyzing) activity

Specific function:

ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

Gene Name:

ASN1

Uniprot ID:

P49089

Molecular weight:

64469.60156

Reactions

General function:

Involved in catalytic activity

Specific function:

Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate

Gene Name:

GLT1

Uniprot ID:

Q12680

Molecular weight:

238100.0

Reactions

General function:

Involved in asparagine synthase (glutamine-hydrolyzing) activity

Specific function:

ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate

Gene Name:

ASN2

Uniprot ID:

P49090

Molecular weight:

64592.5

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Plays an important role in the regulation of phospholipid synthesis

Gene Name:

URA8

Uniprot ID:

P38627

Molecular weight:

63055.69922

Reactions

General function:

Involved in NAD+ synthase (glutamine-hydrolyzing) activity

Specific function:

ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate

Gene Name:

QNS1

Uniprot ID:

P38795

Molecular weight:

80684.89844

Reactions

General function:

Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor

Specific function:

Hydrolysis of urea to ammonia and CO(2)

Gene Name:

DUR1

Uniprot ID:

P32528

Molecular weight:

201830.0

Reactions

General function:

Involved in galactokinase activity

Specific function:

ATP + D-galactose = ADP + alpha-D-galactose 1- phosphate

Gene Name:

GAL1

Uniprot ID:

P04385

Molecular weight:

57943.80078

Reactions

General function:

Involved in UDP-glucose:hexose-1-phosphate uridylyltransferase activity

Specific function:

UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose

Gene Name:

GAL7

Uniprot ID:

P08431

Molecular weight:

42384.69922

Reactions

General function:

Involved in sulfate adenylyltransferase (ATP) activity

Specific function:

Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur- containing amino acids

Gene Name:

MET3

Uniprot ID:

P08536

Molecular weight:

57724.0

Reactions

General function:

Involved in ATP adenylyltransferase activity

Specific function:

Ap4A phosphorylase catabolizes Ap4N nucleotides (where N is A,C,G or U). Additionally this enzyme catalyzes the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulfate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP

Gene Name:

APA1

Uniprot ID:

P16550

Molecular weight:

36492.19922

Reactions

General function:

Involved in inositol trisphosphate 3-kinase activity

Specific function:

Has kinase activity and phosphorylates inositol-1,4,5- trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4). Has low kinase activity towards InsP6. Originally it was proposed that the ARGRI and ARGRIII proteins are more likely to be involved in the control of ARGRII activity

Gene Name:

ARG82

Uniprot ID:

P07250

Molecular weight:

40352.5

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

Catalyzes the committed step of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway. Also exhibits choline kinase activity but its preferred substrate is ethanolamine

Gene Name:

EKI1

Uniprot ID:

Q03764

Molecular weight:

61656.39844

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

Responsible for phosphatidylcholine synthesis via the CDP-choline pathway. Also exhibits ethanolamine kinase activity but at 14% efficiency compared with choline

Gene Name:

CKI1

Uniprot ID:

P20485

Molecular weight:

66316.0

Reactions

General function:

Involved in 1-aminocyclopropane-1-carboxylate synthase activity

Specific function:

Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA)

Gene Name:

BNA3

Uniprot ID:

P47039

Molecular weight:

50081.89844

Reactions

General function:

Involved in catalytic activity

Specific function:

Synthesis of fructose 2,6-bisphosphate

Gene Name:

PFK27

Uniprot ID:

Q12471

Molecular weight:

45317.10156

Reactions

General function:

Involved in catalytic activity

Specific function:

Synthesis of fructose 2,6-bisphosphate

Gene Name:

PFK26

Uniprot ID:

P40433

Molecular weight:

93416.20313

Reactions

General function:

Involved in adenylosuccinate synthase activity

Specific function:

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP

Gene Name:

ADE12

Uniprot ID:

P80210

Molecular weight:

48279.10156

Reactions

General function:

Involved in hydrolase activity

Specific function:

May eliminate potentially toxic dinucleoside polyphosphates during sporulation. Most active against diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A). Can also hydrolyze diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A), adenosine 5'-pentaphosphate, and adenosine 5'-tetraphosphate are also substrates, but not diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. Also cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate)

Gene Name:

DDP1

Uniprot ID:

Q99321

Molecular weight:

21572.30078

Reactions

General function:

Involved in inositol trisphosphate 3-kinase activity

Specific function:

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance

Gene Name:

KCS1

Uniprot ID:

Q12494

Molecular weight:

119549.0

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP- InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2- InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer. Required for maintaining celllular integrity, normal growth and interactions with the ARP complex. Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability. Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth

Gene Name:

VIP1

Uniprot ID:

Q06685

Molecular weight:

129754.0

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the oxidation of D-arabinose, L-xylose, L- fucose and L-galactose in the presence of NADP+

Gene Name:

ARA1

Uniprot ID:

P38115

Molecular weight:

38883.19922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

D-arabinose + NAD(+) = D-arabinono-1,4-lactone + NADH

Gene Name:

ARA2

Uniprot ID:

Q04212

Molecular weight:

38220.0

Reactions

General function:

Involved in iron ion binding

Specific function:

Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol

Gene Name:

ERG11

Uniprot ID:

P10614

Molecular weight:

60719.80078

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

Gene Name:

GSH2

Uniprot ID:

Q08220

Molecular weight:

55814.69922

Reactions

General function:

Involved in 5-aminolevulinate synthase activity

Specific function:

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2)

Gene Name:

HEM1

Uniprot ID:

P09950

Molecular weight:

59361.69922

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide

Gene Name:

ADE5

Uniprot ID:

P07244

Molecular weight:

86067.39844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine

Gene Name:

LPD1

Uniprot ID:

P09624

Molecular weight:

54009.69922

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Required for the methylation step in diphthamide biosynthesis

Gene Name:

DPH5

Uniprot ID:

P32469

Molecular weight:

33847.0

Reactions

General function:

Involved in glycerone kinase activity

Specific function:

ATP + glycerone = ADP + glycerone phosphate

Gene Name:

DAK2

Uniprot ID:

P43550

Molecular weight:

62134.0

Reactions

General function:

Involved in glycerone kinase activity

Specific function:

ATP + glycerone = ADP + glycerone phosphate

Gene Name:

DAK1

Uniprot ID:

P54838

Molecular weight:

62206.10156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Unknown function which seems to be not essential

Gene Name:

GCY1

Uniprot ID:

P14065

Molecular weight:

35078.89844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate

Gene Name:

LYS1

Uniprot ID:

P38998

Molecular weight:

41464.39844

Reactions

General function:

Involved in binding

Specific function:

N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP(+) + H(2)O = L-glutamate + L-2-aminoadipate 6-semialdehyde + NADPH

Gene Name:

LYS9

Uniprot ID:

P38999

Molecular weight:

48917.30078

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Siroheme synthase involved in methionine biosynthesis

Gene Name:

MET1

Uniprot ID:

P36150

Molecular weight:

66124.70313

Reactions

General function:

Involved in zinc ion binding

Specific function:

An alcohol + NAD(+) = an aldehyde or ketone + NADH

Gene Name:

ADH3

Uniprot ID:

P07246

Molecular weight:

40369.19922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

Gene Name:

ALD2

Uniprot ID:

P47771

Molecular weight:

55187.39844

Reactions

General function:

Involved in zinc ion binding

Specific function:

Oxidizes long-chain alcohols and, in the presence of glutathione, is able to oxidize formaldehyde. Is responsible for yeast resistance to formaldehyde

Gene Name:

SFA1

Uniprot ID:

P32771

Molecular weight:

41041.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(+) + H(2)O = an acid + NADH

Gene Name:

ALD4

Uniprot ID:

P46367

Molecular weight:

56723.19922

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Second most abundant of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids valine, isoleucine, phenylalanine, and tryptophan, whereas leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins

Gene Name:

PDC5

Uniprot ID:

P16467

Molecular weight:

61911.60156

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Minor of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids valine, isoleucine, phenylalanine, and tryptophan, whereas leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins. The expression level of this protein in the presence of fermentable carbon sources is so low that it can not compensate for the other two pyruvate decarboxylases to sustain fermentation

Gene Name:

PDC6

Uniprot ID:

P26263

Molecular weight:

61579.89844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

Gene Name:

ALD3

Uniprot ID:

P54114

Molecular weight:

55384.80078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(+) + H(2)O = an acid + NADH

Gene Name:

ALD6

Uniprot ID:

P54115

Molecular weight:

54413.69922

Reactions

General function:

Involved in zinc ion binding

Specific function:

This isozyme preferentially catalyzes the conversion of primary unbranched alcohols to their corresponding aldehydes. Also also shows activity toward secondary alcohols

Gene Name:

ADH1

Uniprot ID:

P00330

Molecular weight:

36849.0

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Minor mitochondrial aldehyde dehydrogenase isoform. Plays a role in regulation or biosynthesis of electron transport chain components. Involved in the biosynthesis of acetate during anaerobic growth on glucose

Gene Name:

ALD5

Uniprot ID:

P40047

Molecular weight:

56620.39844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Reduces acetaldehyde to ethanol during glucose fermentation. Specific for ethanol. Shows drastically reduced activity towards primary alcohols from 4 carbon atoms upward. Isomers of aliphatic alcohol, as well as secondary alcohols and glycerol are not used at all

Gene Name:

ADH4

Uniprot ID:

P10127

Molecular weight:

41141.69922

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Major of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-ketoacids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids valine, isoleucine, phenylalanine, and tryptophan, whereas leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins

Gene Name:

PDC1

Uniprot ID:

P06169

Molecular weight:

61494.89844

Reactions

General function:

Involved in zinc ion binding

Specific function:

An alcohol + NAD(+) = an aldehyde or ketone + NADH

Gene Name:

ADH5

Uniprot ID:

P38113

Molecular weight:

37647.89844

Reactions

General function:

Involved in zinc ion binding

Specific function:

This isozyme preferentially catalyzes the conversion of ethanol to acetaldehyde. Acts on a variety of primary unbranched aliphatic alcohols

Gene Name:

ADH2

Uniprot ID:

P00331

Molecular weight:

36731.60156

Reactions

General function:

Involved in catalytic activity

Specific function:

Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)

Gene Name:

UTR4

Uniprot ID:

P32626

Molecular weight:

25187.19922

Reactions

General function:

Involved in catalytic activity

Specific function:

Orotidine 5'-phosphate = UMP + CO(2)

Gene Name:

URA3

Uniprot ID:

P03962

Molecular weight:

29239.30078

Reactions

General function:

Involved in magnesium ion binding

Specific function:

May function in the production of NADPH for fatty acid and sterol synthesis

Gene Name:

IDP3

Uniprot ID:

P53982

Molecular weight:

47856.0

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Mitochondrial IDP1 may regulate flux through the tricarboxylic acid cycle and respiration. Its probably critical function is the production of NADPH

Gene Name:

IDP1

Uniprot ID:

P21954

Molecular weight:

48189.89844

Reactions

General function:

Involved in magnesium ion binding

Specific function:

May function in the production of NADPH for fatty acid and sterol synthesis

Gene Name:

IDP2

Uniprot ID:

P41939

Molecular weight:

46561.89844

Reactions

General function:

Involved in dihydroorotase activity

Specific function:

(S)-dihydroorotate + H(2)O = N-carbamoyl-L- aspartate

Gene Name:

URA4

Uniprot ID:

P20051

Molecular weight:

40313.0

Reactions

General function:

Involved in glutamate N-acetyltransferase activity

Specific function:

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis:the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate

Gene Name:

ARG7

Uniprot ID:

Q04728

Molecular weight:

47848.30078

Reactions

General function:

Involved in 3-dehydroquinate dehydratase activity

Specific function:

The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis

Gene Name:

ARO1

Uniprot ID:

P08566

Molecular weight:

174754.0

Reactions

General function:

Involved in ureidoglycolate hydrolase activity

Specific function:

Utilization of purines as secondary nitrogen sources, when primary sources are limiting

Gene Name:

DAL3

Uniprot ID:

P32459

Molecular weight:

21726.59961

Reactions

General function:

Involved in catalytic activity

Specific function:

This isozyme is necessary for growth on acetate as sole C-source

Gene Name:

MLS1

Uniprot ID:

P30952

Molecular weight:

62790.60156

Reactions

General function:

Involved in catalytic activity

Specific function:

This isozyme is involved in the degradation of allantoin (purine catabolism)

Gene Name:

DAL7

Uniprot ID:

P21826

Molecular weight:

62793.39844

Reactions

General function:

Involved in aspartate-semialdehyde dehydrogenase activity

Specific function:

This enzyme catalyzes the second step in the common metabolic pathway to synthesize Thr and Met from Asp

Gene Name:

HOM2

Uniprot ID:

P13663

Molecular weight:

39543.30078

Reactions

General function:

Involved in binding

Specific function:

Responsible for the reduction of the keto group on the C-3 of sterols. Also facilitates the association of ERG7 with lipid particles preventing its digestion in the endoplasmic reticulum and the lipid particles

Gene Name:

ERG27

Uniprot ID:

Q12452

Molecular weight:

39724.39844

Reactions

General function:

Involved in nucleobase transmembrane transporter activity

Specific function:

Thiamine-regulated, high affinity import carrier of pyridoxine, pyridoxal and pyridoxamine

Gene Name:

TPN1

Uniprot ID:

P53099

Molecular weight:

64545.80078

General function:

Involved in catalytic activity

Specific function:

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Involved in cell cycle regulation

Gene Name:

BAT2

Uniprot ID:

P47176

Molecular weight:

41624.39844

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Appears to be involved in the regulation of the transition from G1 to S phase in the cell cycle. High copy suppressor of a temperature-sensitive mutation in the ABC transporter, ATM1

Gene Name:

BAT1

Uniprot ID:

P38891

Molecular weight:

43595.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

(R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH

Gene Name:

ILV5

Uniprot ID:

P06168

Molecular weight:

44368.10156

Reactions

General function:

Involved in ferrochelatase activity

Specific function:

Catalyzes the ferrous insertion into protoporphyrin IX

Gene Name:

HEM15

Uniprot ID:

P16622

Molecular weight:

44595.80078

Reactions

General function:

Involved in UDP-N-acetylglucosamine diphosphorylase act

Specific function:

UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-glucosamine

Gene Name:

QRI1

Uniprot ID:

P43123

Molecular weight:

53475.60156

Reactions

General function:

Involved in N-acetyltransferase activity

Specific function:

Acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate

Gene Name:

GNA1

Uniprot ID:

P43577

Molecular weight:

18134.80078

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2- hydroxybutane-1,2,4-tricarboxylate + CoA

Gene Name:

LYS21

Uniprot ID:

Q12122

Molecular weight:

48593.80078

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis. May be involved in lipid particle synthesis from the endoplasmic reticulum and ergosterol biosynthesis

Gene Name:

DGA1

Uniprot ID:

Q08650

Molecular weight:

47710.89844

Reactions

General function:

Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Specific function:

Catalyzes the conversion of dihydroceramide and also phytoceramide to dihydrosphingosine or phytosphingosine. Prefers dihydroceramide. Very low reverse hydrolysis activity, catalyzing synthesis of dihydroceramide from fatty acid and dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide. May play a role in heat stress response

Gene Name:

YDC1

Uniprot ID:

Q02896

Molecular weight:

37230.5

Reactions

General function:

Involved in 2-isopropylmalate synthase activity

Specific function:

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Redundant to LEU4, responsible of about 20% of alpha-IPMS activity. Involved in leucine synthesis

Gene Name:

LEU9

Uniprot ID:

Q12166

Molecular weight:

67199.60156

Reactions

General function:

Involved in fatty acid elongase activity

Specific function:

Involved in synthesis of 1,3-beta-glucan. Could be a subunit of 1,3-beta-glucan synthase. Could be also a component of the membrane bound fatty acid elongation systems that produce the 26-carbon very long chain fatty acids that are precursors for ceramide and sphingolipids. Appears to be involved in the elongation of fatty acids up to 24 carbons. Appears to have the highest affinity for substrates with chain length less than 22 carbons

Gene Name:

FEN1

Uniprot ID:

P25358

Molecular weight:

40001.80078

Reactions

General function:

Involved in catalytic activity

Specific function:

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation. It may be involved in overall regulation of acetylation during melatonin synthesis

Gene Name:

ACH1

Uniprot ID:

P32316

Molecular weight:

58711.5

Reactions

General function:

Involved in hydroxymethylglutaryl-CoA reductase (NADPH) activity

Specific function:

This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of the sterol biosynthesis

Gene Name:

HMG1

Uniprot ID:

P12683

Molecular weight:

115624.0

Reactions

General function:

Involved in hydroxymethylglutaryl-CoA reductase (NADPH) activity

Specific function:

This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of the sterol biosynthesis

Gene Name:

HMG2

Uniprot ID:

P12684

Molecular weight:

115691.0

Reactions

General function:

Involved in transferase activity, transferring nitrogenous groups

Specific function:

Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine

Gene Name:

LCB1

Uniprot ID:

P25045

Molecular weight:

62206.60156

Reactions

General function:

Involved in acyl-CoA dehydrogenase activity

Specific function:

Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2)

Gene Name:

POX1

Uniprot ID:

P13711

Molecular weight:

84041.39844

Reactions

General function:

Involved in hydroxymethylglutaryl-CoA synthase activity

Specific function:

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase

Gene Name:

ERG13

Uniprot ID:

P54839

Molecular weight:

55013.10156

Reactions

General function:

Involved in dephospho-CoA kinase activity

Specific function:

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

Gene Name:

CAB5

Uniprot ID:

Q03941

Molecular weight:

27339.5

Reactions

General function:

Involved in protein binding

Specific function:

Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAC1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Deletion of LAG1 results in a pronounced increase (approximately 50%) in mean and in maximum life span

Gene Name:

LAG1

Uniprot ID:

P38703

Molecular weight:

48454.10156

Reactions

General function:

Involved in 2-isopropylmalate synthase activity

Specific function:

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)

Gene Name:

LEU4

Uniprot ID:

P06208

Molecular weight:

68408.29688

Reactions

General function:

Involved in fatty acid elongase activity

Specific function:

May be a membrane bound enzyme involved in the highly specific elongation of saturated 14-carbon fatty acids (14:0) to 16-carbon species (16:0)

Gene Name:

ELO1

Uniprot ID:

P39540

Molecular weight:

36233.60156

Reactions

General function:

Involved in acyltransferase activity

Specific function:

May be an acyltransferase with an altered substrate specificity that enables it to use a C-26-CoA in place of the C-16 or C-18-CoAs used by the wild-type protein

Gene Name:

SLC1

Uniprot ID:

P33333

Molecular weight:

33886.69922

Reactions

General function:

Involved in acyl carrier activity

Specific function:

Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Gene Name:

ACP1

Uniprot ID:

P32463

Molecular weight:

13942.5

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + 2-oxoglutarate = (R)-2- hydroxybutane-1,2,4-tricarboxylate + CoA

Gene Name:

LYS20

Uniprot ID:

P48570

Molecular weight:

47098.39844

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

Gene Name:

POT1

Uniprot ID:

P27796

Molecular weight:

44729.89844

Reactions

General function:

Involved in transferase activity

Specific function:

Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for:[acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase

Gene Name:

FAS1

Uniprot ID:

P07149

Molecular weight:

228689.0

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

CIT3

Uniprot ID:

P43635

Molecular weight:

53810.69922

Reactions

General function:

Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Specific function:

Hydrolyzes phytoceramide and also dihydroceramide into phytosphingosine or dihydrosphingosine. Prefers phytoceramide. Has also reverse hydrolysis activity, catalyzing synthesis of phytoceramide and dihydroceramide from palmitic acid and phytosphingosine or dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide

Gene Name:

YPC1

Uniprot ID:

P38298

Molecular weight:

36419.39844

Reactions

General function:

Involved in acyltransferase activity

Specific function:

G-3-P/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase

Gene Name:

GPT1

Uniprot ID:

P32784

Molecular weight:

85693.5

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of mitochondrial acyl-carrier-protein

Gene Name:

PPT2

Uniprot ID:

Q12036

Molecular weight:

19973.0

Reactions

General function:

Involved in identical protein binding

Specific function:

Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAG1. Facilitates ER-to-Golgi transport of GPI-anchored proteins

Gene Name:

LAC1

Uniprot ID:

P28496

Molecular weight:

48991.60156

Reactions

General function:

Involved in acyltransferase activity

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)

Gene Name:

PDA2

Uniprot ID:

P12695

Molecular weight:

51817.5

Reactions

General function:

Involved in acyl-CoA thioesterase activity

Specific function:

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH

Gene Name:

TES1

Uniprot ID:

P41903

Molecular weight:

40259.39844

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

CIT2

Uniprot ID:

P08679

Molecular weight:

51412.89844

Reactions

General function:

Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Specific function:

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Gene Name:

CIT1

Uniprot ID:

P00890

Molecular weight:

53359.60156

Reactions

General function:

Involved in arginine biosynthetic process

Specific function:

N-acetylglutamate synthase involved in arginine biosynthesis

Gene Name:

ARG2

Uniprot ID:

P40360

Molecular weight:

65609.5

Reactions

General function:

Involved in glycylpeptide N-tetradecanoyltransferase activity

Specific function:

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N- terminal glycine in the nascent polypeptide substrates. Uncharged amino acids are preferred at position 2 while neutral residues are favored at positions 3 and 4. Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6

Gene Name:

NMT1

Uniprot ID:

P14743

Molecular weight:

52837.10156

Reactions

General function:

Involved in acyltransferase activity

Specific function:

G-3-P/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase

Gene Name:

GPT2

Uniprot ID:

P36148

Molecular weight:

83644.0

Reactions

General function:

Involved in cysteine biosynthetic process from serine

Specific function:

O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate

Gene Name:

Not Available

Uniprot ID:

P53206

Molecular weight:

42800.5

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate

Gene Name:

Not Available

Uniprot ID:

Q04533

Molecular weight:

74312.70313

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

Transforms O-acetylhomoserine into homocysteine and O- acetylserine into cysteine

Gene Name:

MET17

Uniprot ID:

P06106

Molecular weight:

48671.39844

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate

Gene Name:

CYS3

Uniprot ID:

P31373

Molecular weight:

42541.69922

Reactions

General function:

Coenzyme transport and metabolism

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

P40506

Molecular weight:

41892.69922

Reactions

General function:

Involved in glutamate-cysteine ligase activity

Specific function:

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

Gene Name:

GSH1

Uniprot ID:

P32477

Molecular weight:

78252.89844

Reactions

General function:

Involved in pyridoxal phosphate binding

Specific function:

O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate

Gene Name:

STR2

Uniprot ID:

P47164

Molecular weight:

72349.89844

Reactions

General function:

Involved in acetylglutamate kinase activity

Specific function:

N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH

Gene Name:

ARG5

Uniprot ID:

Q01217

Molecular weight:

94868.39844

Reactions

General function:

Involved in hydrolase activity

Specific function:

Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Has equal high activity toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate. Has no activity toward GMP. Required for Golgi glycosylation and cell wall integrity. Together with CDC55, required for adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity, the apyrase activity is not required for this function. Plays a role in sphingolipid synthesis

Gene Name:

YND1

Uniprot ID:

P40009

Molecular weight:

71851.20313

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway

Gene Name:

ALG13

Uniprot ID:

P53178

Molecular weight:

22660.90039

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the conversion of uridine into UMP and cytidine into CMP in the pyrimidine salvage pathway

Gene Name:

URK1

Uniprot ID:

P27515

Molecular weight:

56295.5

Reactions

General function:

Involved in zinc ion binding

Specific function:

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis

Gene Name:

CDD1

Uniprot ID:

Q06549

Molecular weight:

15535.90039

Reactions

General function:

Involved in argininosuccinate synthase activity

Specific function:

In yeast, as can have a catabolic function since it allows efficient utilization of citrulline via arginine and the reactions involved in the arginase pathway

Gene Name:

ARG1

Uniprot ID:

P22768

Molecular weight:

46939.30078

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolyzes the N-acetamido groups of N-acetyl-D- glucosamine residues in chitin

Gene Name:

CDA1

Uniprot ID:

Q06702

Molecular weight:

34642.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Hydrolyzes the N-acetamido groups of N-acetyl-D- glucosamine residues in chitin

Gene Name:

CDA2

Uniprot ID:

Q06703

Molecular weight:

35692.80078

Reactions

General function:

Involved in N-acetylglucosaminylphosphatidylinositol de

Specific function:

Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol

Gene Name:

GPI12

Uniprot ID:

P23797

Molecular weight:

35445.60156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Maintains high levels of reduced glutathione in the cytosol

Gene Name:

GLR1

Uniprot ID:

P41921

Molecular weight:

53440.60156

Reactions

General function:

Involved in deaminase activity

Specific function:

Adenosine + H(2)O = inosine + NH(3)

Gene Name:

AAH1

Uniprot ID:

P53909

Molecular weight:

39634.69922

Reactions

General function:

Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Specific function:

3-phospho-D-glycerate + NAD(+) = 3- phosphonooxypyruvate + NADH

Gene Name:

SER33

Uniprot ID:

P40510

Molecular weight:

51187.80078

Reactions

General function:

Involved in carboxyl- or carbamoyltransferase activity

Specific function:

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline

Gene Name:

ARG3

Uniprot ID:

P05150

Molecular weight:

37844.80078

Reactions

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

Involved in pre-tRNA splicing. CTP- dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA). Controls phosphatidate levels at the nuclear envelope. Counteracts the activity of PAH1/SMP2. Involved in the resistance to nickel chloride and nalidixic acid. May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus

Gene Name:

DGK1

Uniprot ID:

Q12382

Molecular weight:

32839.80078

Reactions

General function:

Involved in ATP binding

Specific function:

RAR (regulation of autonomous replication) is a protein whose activity increases the mitotic stability of plasmids

Gene Name:

ERG12

Uniprot ID:

P07277

Molecular weight:

48458.89844

Reactions

General function:

Involved in phosphoribosylaminoimidazole carboxylase activity

Specific function:

5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)

Gene Name:

ADE2

Uniprot ID:

P21264

Molecular weight:

62338.69922

Reactions

General function:

Involved in catalytic activity

Specific function:

L-serine = pyruvate + NH(3)

Gene Name:

CHA1

Uniprot ID:

P25379

Molecular weight:

39301.0

Reactions

General function:

Involved in ATP binding

Specific function:

Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose

Gene Name:

HXK2

Uniprot ID:

P04807

Molecular weight:

53942.0

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + D-hexose = ADP + D-hexose 6-phosphate

Gene Name:

HXK1

Uniprot ID:

P04806

Molecular weight:

53737.89844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the production and accumulation of glycerol during hyperosmotic stress conditions. Glycerol acts as a osmoregulator that prevents loss of water and turgor of the cells

Gene Name:

GPD1

Uniprot ID:

Q00055

Molecular weight:

42868.5

Reactions

General function:

Involved in protein binding

Specific function:

Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source

Gene Name:

GDE1

Uniprot ID:

Q02979

Molecular weight:

138013.0

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the production of glycerol under anaerobic growth conditions. Glycerol production serves as a redox sink by consuming the excess cytosolic NADH during anaerobic metabolism

Gene Name:

GPD2

Uniprot ID:

P41911

Molecular weight:

49421.30078

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + glycerol = ADP + sn-glycerol 3- phosphate

Gene Name:

GUT1

Uniprot ID:

P32190

Molecular weight:

79823.60156

Reactions

General function:

Involved in phosphotransferase activity, for other substituted phosphate groups

Specific function:

Essential for the viability of mitochondrial petite mutant. Catalyzes the committed step to the synthesis of the acidic phospholipids

Gene Name:

PGS1

Uniprot ID:

P25578

Molecular weight:

59369.69922

Reactions

General function:

Involved in thiosulfate sulfurtransferase activity

Specific function:

Thiosulfate + cyanide = sulfite + thiocyanate

Gene Name:

Not Available

Uniprot ID:

Q08686

Molecular weight:

34218.60156

Reactions

General function:

Involved in catalytic activity

Specific function:

Dethiobiotin + sulfur + 2 S-adenosyl-L- methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine

Gene Name:

BIO2

Uniprot ID:

P32451

Molecular weight:

41883.80078

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin

Gene Name:

BIO4

Uniprot ID:

P53630

Molecular weight:

26256.69922

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate

Gene Name:

ADE1

Uniprot ID:

P27616

Molecular weight:

34603.10156

Reactions

General function:

Involved in 6-phosphofructokinase activity

Specific function:

ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate

Gene Name:

PFK1

Uniprot ID:

P16861

Molecular weight:

107969.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Involved in the catabolism of quinolinic acid (QA)

Gene Name:

BNA6

Uniprot ID:

P43619

Molecular weight:

32364.69922

Reactions

General function:

Involved in dihydrofolate reductase activity

Specific function:

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis

Gene Name:

DFR1

Uniprot ID:

P07807

Molecular weight:

24260.80078

Reactions

General function:

Involved in tetrahydrofolylpolyglutamate synthase activity

Specific function:

Conversion of folates to polyglutamate derivatives

Gene Name:

FOL3

Uniprot ID:

Q12676

Molecular weight:

47850.80078

Reactions

General function:

Involved in formate-tetrahydrofolate ligase activity

Specific function:

5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH

Gene Name:

MIS1

Uniprot ID:

P09440

Molecular weight:

106216.0

Reactions

General function:

Involved in methionyl-tRNA formyltransferase activity

Specific function:

Formylates methionyl-tRNA in mitochondria

Gene Name:

FMT1

Uniprot ID:

P32785

Molecular weight:

44616.19922

Reactions

General function:

Involved in formate-tetrahydrofolate ligase activity

Specific function:

5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH

Gene Name:

ADE3

Uniprot ID:

P07245

Molecular weight:

102204.0

Reactions

General function:

Involved in 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity

Specific function:

Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation

Gene Name:

MET6

Uniprot ID:

P05694

Molecular weight:

85859.20313

Reactions

General function:

Involved in porphobilinogen synthase activity

Specific function:

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen

Gene Name:

HEM2

Uniprot ID:

P05373

Molecular weight:

37739.69922

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

Gene Name:

HEM13

Uniprot ID:

P11353

Molecular weight:

37711.30078

Reactions

General function:

Involved in uroporphyrinogen decarboxylase activity

Specific function:

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

Gene Name:

HEM12

Uniprot ID:

P32347

Molecular weight:

41348.69922

Reactions

General function:

Involved in riboflavin kinase activity

Specific function:

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme

Gene Name:

FMN1

Uniprot ID:

Q03778

Molecular weight:

24536.90039

Reactions

General function:

Involved in FMN reductase activity

Specific function:

Has several reductase activities that are NAD(P)H- dependent and involve FMN as a cofactor, ferricyanide being the best substrate for reduction. May be involved in ferric iron assimilation

Gene Name:

LOT6

Uniprot ID:

Q07923

Molecular weight:

21280.40039

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme

Gene Name:

FAD1

Uniprot ID:

P38913

Molecular weight:

35545.80078

Reactions

General function:

Involved in zinc ion binding

Specific function:

L-iditol + NAD(+) = L-sorbose + NADH

Gene Name:

SOR1

Uniprot ID:

P35497

Molecular weight:

38165.39844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE1, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxydation

Gene Name:

NDE2

Uniprot ID:

Q07500

Molecular weight:

61658.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE2, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxydation

Gene Name:

NDE1

Uniprot ID:

P40215

Molecular weight:

62773.60156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the oxidation of NADH generated inside the Mitochondrion

Gene Name:

NDI1

Uniprot ID:

P32340

Molecular weight:

57249.30078

Reactions

General function:

Involved in phosphotransferase activity, for other substituted phosphate groups

Specific function:

Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. The multiple transmembrane domains and lumenal hydrophilic domains of the cholinephosphotransferase might participate in the transport process

Gene Name:

CPT1

Uniprot ID:

P17898

Molecular weight:

44829.0

Reactions

General function:

Involved in catalytic activity

Specific function:

CTP + choline phosphate = diphosphate + CDP- choline

Gene Name:

PCT1

Uniprot ID:

P13259

Molecular weight:

49405.80078

Reactions

General function:

Involved in phosphotransferase activity, for other substituted phosphate groups

Specific function:

Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl ethanolamine to the lumenal surface. The multiple transmembrane domains and lumenal hydrophilic domains of the ethanolaminephosphotransferase might participate in the transport process. EPT1 catalyzes both choline- and ethanolamine-phosphotransferase reactions

Gene Name:

EPT1

Uniprot ID:

P22140

Molecular weight:

44559.30078

Reactions

General function:

Involved in zinc ion binding

Specific function:

Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4

Gene Name:

FCY1

Uniprot ID:

Q12178

Molecular weight:

17506.90039

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NAD(+) = 2-oxoglutarate + NH(3) + NADH

Gene Name:

GDH2

Uniprot ID:

P33327

Molecular weight:

124331.0

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH

Gene Name:

GDH3

Uniprot ID:

P39708

Molecular weight:

49626.80078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH

Gene Name:

GDH1

Uniprot ID:

P07262

Molecular weight:

49569.60156

Reactions

General function:

Involved in catalytic activity

Specific function:

Exhibits dehydratase activity specific for L-threo-3- hydroxyaspartate

Gene Name:

SRY1

Uniprot ID:

P36007

Molecular weight:

34898.69922

Reactions

General function:

Involved in deaminase activity

Specific function:

AMP deaminase plays a critical role in energy metabolism

Gene Name:

AMD1

Uniprot ID:

P15274

Molecular weight:

93300.79688

Reactions

General function:

Involved in zinc ion binding

Specific function:

Involved in riboflavin biosynthesis. Converts 2,5- diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate into 5- amino-6-(ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate

Gene Name:

RIB2

Uniprot ID:

Q12362

Molecular weight:

67035.29688

Reactions

General function:

Involved in zinc ion binding

Specific function:

Supplies the nucleotide substrate for thymidylate synthetase

Gene Name:

DCD1

Uniprot ID:

P06773

Molecular weight:

35645.69922

Reactions

General function:

Involved in hydrolase activity

Specific function:

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia

Gene Name:

GUD1

Uniprot ID:

Q07729

Molecular weight:

55203.19922

Reactions

General function:

Involved in magnesium ion binding

Specific function:

5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1- diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)

Gene Name:

PRS5

Uniprot ID:

Q12265

Molecular weight:

53504.19922

Reactions

General function:

Involved in hydrolase activity

Specific function:

NAD(+) + H(2)O = AMP + NMN

Gene Name:

NPY1

Uniprot ID:

P53164

Molecular weight:

43516.0

Reactions

General function:

Involved in magnesium ion binding

Specific function:

5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1- diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)

Gene Name:

PRS2

Uniprot ID:

P38620

Molecular weight:

34764.60156

Reactions

General function:

Involved in 3',5'-cyclic-AMP phosphodiesterase activity

Specific function:

Controls the level of cAMP in yeast cells, together with the high-affinity cAMP phosphodiesterase (PDE2)

Gene Name:

PDE1

Uniprot ID:

P22434

Molecular weight:

42015.69922

Reactions

General function:

Involved in catalytic activity

Specific function:

Cleaves A-5'-PPP-5'A to yield AMP and ADP. Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine. Is most effective on dinucleoside triphosphates. Negatively regulates intracellular dinucleoside polyphosphate levels, which elevate following heat shock

Gene Name:

HNT2

Uniprot ID:

P49775

Molecular weight:

23541.59961

Reactions

General function:

Involved in magnesium ion binding

Specific function:

5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1- diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)

Gene Name:

PRS1

Uniprot ID:

P32895

Molecular weight:

47047.0

Reactions

General function:

Involved in thiamine diphosphokinase activity

Specific function:

Essential protein, it is the only enzyme in yeast capable of synthesizing thiamine pyrophosphate (TPP)

Gene Name:

THI80

Uniprot ID:

P35202

Molecular weight:

36615.69922

Reactions

General function:

Involved in biotin-[acetyl-CoA-carboxylase] ligase activity

Specific function:

Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase

Gene Name:

BPL1

Uniprot ID:

P48445

Molecular weight:

76362.39844

Reactions

General function:

Involved in magnesium ion binding

Specific function:

5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1- diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)

Gene Name:

PRS3

Uniprot ID:

P38689

Molecular weight:

35123.30078

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)

Gene Name:

Not Available

Uniprot ID:

P38708

Molecular weight:

77385.70313

Reactions

General function:

Involved in ligase activity

Specific function:

Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha- aminoadipate by NADPH

Gene Name:

LYS2

Uniprot ID:

P07702

Molecular weight:

155344.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Controls the level of cAMP in yeast cells, together with the low-affinity cAMP phosphodiesterase (PDE1)

Gene Name:

PDE2

Uniprot ID:

P06776

Molecular weight:

60999.19922

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)

Gene Name:

NRK1

Uniprot ID:

P53915

Molecular weight:

27689.30078

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

Gene Name:

THR1

Uniprot ID:

P17423

Molecular weight:

38712.0

Reactions

General function:

Involved in ATP binding

Specific function:

Has kinase activity and phosphorylates inositol- 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate

Gene Name:

IPK1

Uniprot ID:

Q06667

Molecular weight:

32917.69922

Reactions

General function:

Involved in monooxygenase activity

Specific function:

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid

Gene Name:

BNA4

Uniprot ID:

P38169

Molecular weight:

52428.89844

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively

Gene Name:

BNA5

Uniprot ID:

Q05979

Molecular weight:

51031.60156

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + D-ribose = ADP + D-ribose 5-phosphate

Gene Name:

RBK1

Uniprot ID:

P25332

Molecular weight:

36923.80078

Reactions

General function:

Involved in nucleotidyltransferase activity

Specific function:

ATP + nicotinamide ribonucleotide = diphosphate + NAD(+);ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+

Gene Name:

NMA2

Uniprot ID:

P53204

Molecular weight:

44908.69922

Reactions

General function:

Involved in diacylglycerol kinase activity

Specific function:

Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Involved in the biosynthesis of sphingolipids and ceramides. Required with LCB3 for an effective incorporation of DHS into ceramides through a phosphorylation-dephosphorylation cycle. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance

Gene Name:

LCB4

Uniprot ID:

Q12246

Molecular weight:

69638.60156

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Catalyzes the rate-limiting reaction in the mitochondrial fatty acid synthesis (FAS) type II pathway. Responsible for the production of the mitochondrial malonyl-CoA, used for the biosynthesis of the cofactor lipoic acid. This protein carries three functions:biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase

Gene Name:

HFA1

Uniprot ID:

P32874

Molecular weight:

259161.0

Reactions

General function:

Involved in diacylglycerol kinase activity

Specific function:

Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Redundant to LCB4, is only responsible for few percent of the total activity. Involved in the biosynthesis of sphingolipids and ceramides. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance

Gene Name:

LCB5

Uniprot ID:

Q06147

Molecular weight:

77564.60156

Reactions

General function:

Involved in nucleotidyltransferase activity

Specific function:

ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)

Gene Name:

NMA1

Uniprot ID:

Q06178

Molecular weight:

45858.60156

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

May play a role in endocytic and/or exocytic pathways

Gene Name:

LSB6

Uniprot ID:

P42951

Molecular weight:

70216.39844

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the synthesis of activated sulfate

Gene Name:

MET14

Uniprot ID:

Q02196

Molecular weight:

23060.09961

Reactions

General function:

Involved in NAD+ kinase activity

Specific function:

Specifically phosphorylates NAD in the presence of ATP, dATP, or CTP as phosphoryl donors

Gene Name:

UTR1

Uniprot ID:

P21373

Molecular weight:

59468.69922

Reactions