{"ymdb_id":"YMDB00966","created_at":"2011-06-03T16:11:49.000Z","updated_at":"2016-09-08T18:36:06.000Z","name":"D-mannose 6-phosphate","cas":"3672-15-9","state":"Solid","melting_point":null,"description":"D-Mannose 6-phosphate is the D form of mannose-6-phosphate. Mannose 6-phosphate is an intermediate in carboydrates biosynthesis.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":null,"chebi_id":"17369","hmdb_id":"HMDB01078","kegg_id":"C00275","pubchem_id":"65127","cs_id":"25057696","foodb_id":null,"wikipedia_link":"Mannose_6-phosphate","biocyc_id":"MANNOSE-6P","iupac":"{[(2R,3S,4S,5S)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy}phosphonic acid","traditional_iupac":"mannose 6-phosphate","logp":"-3.056105249333333","pka":"6.248752256962443","alogps_solubility":"3.14e+01 g/l","alogps_logp":"-2.06","alogps_logs":"-0.92","acceptor_count":"8","donor_count":"6","rotatable_bond_count":"3","polar_surface_area":"156.91","refractivity":"46.796299999999995","polarizability":"20.58865044592404","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.64935696086094","pka_strongest_acidic":"1.222936327751123","bioavailability":"1","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["6-O-phosphono-D-mannose","alpha-D-mannose-6-P","alpha-D-mannose-6-phosphate","alpha-delta-mannose-6-P","alpha-delta-mannose-6-phosphate","D-Mannose 6-phosphate","D-Mannose, 6-(dihydrogen phosphate)","delta-Mannose 6-phosphate","Man-6-p","Mannose 6-phosphate","Mannose 6-phosphic acid","Mannose-6-phosphate"],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Mannose Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":15005628,"citation":"Roux, C., Lee, J. H., Jeffery, C. J., Salmon, L. (2004). \"Inhibition of type I and type II phosphomannose isomerases by the reaction intermediate analogue 5-phospho-D-arabinonohydroxamic acid supports a catalytic role for the metal cofactor.\" Biochemistry 43:2926-2934."},{"pubmed_id":19783448,"citation":"Foret, J., de Courcy, B., Gresh, N., Piquemal, J. P., Salmon, L. (2009). \"Synthesis and evaluation of non-hydrolyzable D-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-D-mannose as a new strong inhibitor of phosphomannose isomerases.\" Bioorg Med Chem 17:7100-7107."}],"proteins":[{"created_at":"2011-05-26T17:04:12.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Hexokinase-2","uniprot_id":"P04807","uniprot_name":"HXKB_YEAST","enzyme":true,"transporter":false,"gene_name":"HXK2","num_residues":486,"molecular_weight":"53942.0","theoretical_pi":"4.93","general_function":"Involved in ATP binding","specific_function":"Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose","reactions":[{"id":1627,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1628,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1629,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2462,"direction":"\u003e","locations":"","altext":"ATP + D-hexose = ADP + D-hexose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2463,"direction":"\u003e","locations":"","altext":"ATP + D-fructose = ADP + D-fructose 1-phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":3820,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006335","source":"Smpdb"},{"id":3821,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006342","source":"Smpdb"},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1IG8","cellular_location":null,"genbank_gene_id":"M11181","genbank_protein_id":"171735","gene_card_id":"HXK2","chromosome_location":"chromosome 7","locus":"YGL253W","synonyms":["Hexokinase PII","Hexokinase-B"],"enzyme_classes":["2.7.1.1","2.7.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" 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1-phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":3820,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006335","source":"Smpdb"},{"id":3821,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006342","source":"Smpdb"},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D50617","genbank_protein_id":"836808","gene_card_id":"HXK1","chromosome_location":"chromosome 6","locus":"YFR053C","synonyms":["Hexokinase PI","Hexokinase-A"],"enzyme_classes":["2.7.1.1","2.7.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" hexokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" small molecule metabolic 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Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGTTCATTTAGGTCCAAAGAAACCACAGGCTAGAAAGGGTTCCATGGCTGATGTGCCCAAGGAATTGATGGATGAAATTCATCAGTTGGAAGATATGTTTACAGTTGACAGCGAGACCTTGAGAAAGGTTGTTAAGCACTTTATCGACGAATTGAATAAAGGTTTGACAAAGAAGGGAGGTAACATTCCAATGATTCCCGGTTGGGTCATGGAATTCCCAACAGGTAAAGAATCTGGTAACTATTTGGCCATTGATTTGGGTGGTACTAACTTAAGAGTCGTGTTGGTCAAGTTGAGCGGTAACCATACCTTTGACACCACTCAATCCAAGTATAAACTACCACATGACATGAGAACCACTAAGCACCAAGAGGAGTTATGGTCCTTTATTGCCGACTCTTTGAAGGACTTTATGGTCGAGCAAGAATTGCTAAACACCAAGGACACCTTACCATTAGGTTTCACCTTCTCGTACCCAGCTTCCCAAAACAAGATTAACGAAGGTATTTTGCAAAGATGGACCAAGGGTTTCGATATTCCAAATGTCGAAGGCCACGATGTCGTCCCATTGCTACAAAACGAAATTTCCAAGAGAGAGTTGCCTATTGAAATTGTAGCATTGATTAATGATACTGTTGGTACTTTAATTGCCTCATACTACACTGACCCAGAGACTAAGATGGGTGTGATTTTCGGTACTGGTGTCAACGGTGCTTTCTATGATGTTGTTTCCGATATCGAAAAGTTGGAGGGCAAATTAGCAGACGATATTCCAAGTAACTCTCCAATGGCTATCAATTGTGAATATGGTTCCTTCGATAATGAACATTTGGTCTTGCCAAGAACCAAGTACGATGTTGCTGTCGACGAACAATCTCCAAGACCTGGTCAACAAGCTTTTGAAAAGATGACCTCCGGTTACTACTTGGGTGAATTGTTGCGTCTAGTGTTACTTGAATTAAACGAGAAGGGCTTGATGTTGAAGGATCAAGATCTAAGCAAGTTGAAACAACCATACATCATGGATACCTCCTACCCAGCAAGAATCGAGGATGATCCATTTGAAAACTTGGAAGATACTGATGACATCTTCCAAAAGGACTTTGGTGTCAAGACCACTCTGCCAGAACGTAAGTTGATTAGAAGACTTTGTGAATTGATCGGTACCAGAGCTGCTAGATTAGCTGTTTGTGGTATTGCCGCTATTTGCCAAAAGAGAGGTTACAAGACTGGTCACATTGCCGCTGACGGTTCTGTCTATAACAAATACCCAGGTTTCAAGGAAGCCGCCGCTAAGGGTTTGAGAGATATCTATGGATGGACTGGTGACGCAAGCAAAGATCCAATTACGATTGTTCCAGCTGAGGATGGTTCAGGTGCAGGTGCTGCTGTTATTGCTGCATTGTCCGAAAAAAGAATTGCCGAAGGTAAGTCTCTTGGTATCATTGGCGCTTAA","protein_sequence":"MVHLGPKKPQARKGSMADVPKELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLTKKGGNIPMIPGWVMEFPTGKESGNYLAIDLGGTNLRVVLVKLSGNHTFDTTQSKYKLPHDMRTTKHQEELWSFIADSLKDFMVEQELLNTKDTLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKRELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADDIPSNSPMAINCEYGSFDNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTTLPERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTGHIAADGSVYNKYPGFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAALSEKRIAEGKSLGIIGA"},{"created_at":"2011-05-26T17:23:04.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Mannose-6-phosphate isomerase","uniprot_id":"P29952","uniprot_name":"MPI_YEAST","enzyme":true,"transporter":false,"gene_name":"PMI40","num_residues":429,"molecular_weight":"48188.30078","theoretical_pi":"5.83","general_function":"Involved in mannose-6-phosphate isomerase activity","specific_function":"Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions","reactions":[{"id":1726,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2478,"direction":"\u003e","locations":"Cytoplasm","altext":"D-mannose 6-phosphate = D-fructose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3827,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006343","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"M85238","genbank_protein_id":"172166","gene_card_id":"PMI40","chromosome_location":"chromosome 5","locus":"YER003C","synonyms":["Phosphohexomutase","Phosphomannose isomerase","PMI"],"enzyme_classes":["5.3.1.8"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular oxidoreductase activity"},{"category":"Function","description":" intramolecular oxidoreductase activity, interconverting aldoses and ketoses"},{"category":"Function","description":" mannose-6-phosphate isomerase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"}],"pfams":[{"name":"PMI_typeI","identifier":"PF01238"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Mannose Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCCAACAAGCTGTTCAGGTTAGATGCAGGCTACCAACAATACGACTGGGGTAAAATCGGCTCTTCTTCACGTGTCGCTCAATTTGCTGCCCATTCTGACCCCTCTGTTCAAATTGAACAAGATAAACCATATGCAGAGTTATGGATGGGTACCCACAGCAAGATGCCTTCCTACAACCATGAGTCTAAGGAATCCCTGAGAGATATCATCTCCAAGAACCCCTCTGCCATGTTAGGTAAGGACATTATTGATAAGTTCCACGCCACAAATGAATTGCCCTTCCTTTTCAAAGTTTTGTCCATTGAAAAAGTCTTGTCTATTCAAGCACATCCCGACAAAGCCTTGGGTAAAATATTGCACGCTCAAGATCCTAAGAACTATCCTGATGATAATCACAAACCTGAAATGGCCATCGCTGTGACTGACTTTGAAGGTTTCTGCGGGTTCAAACCTTTGCAAGAGATTGCAGATGAATTGAAACGTATTCCTGAATTACGCAACATTGTTGGTGAAGAAACTTCCAGGAATTTTATTGAGAACATTCAACCTTCTGCTCAGAAAGGTTCCCCAGAAGATGAGCAAAACAAAAAGCTATTGCAAGCTGTTTTCAGCAGGGTCATGAACGCTTCGGATGACAAAATCAAGATTCAAGCTCGCTCCTTGGTCGAAAGATCAAAGAATTCTCCATCAGACTTTAACAAACCTGATTTACCAGAATTAATTCAAAGACTGAATAAACAGTTCCCTGATGACGTGGGTTTGTTTTGTGGATGTTTATTGTTGAATCACTGCAGATTGAATGCTGGTGAAGCCATCTTTTTAAGAGCTAAGGATCCTCACGCCTATATAAGCGGTGATATTATGGAATGTATGGCTGCTTCTGACAACGTAGTTAGAGCAGGCTTCACTCCAAAATTCAAGGATGTTAAAAACTTGGTCTCCATGTTAACCTATACATATGATCCTGTGGAAAAGCAAAAAATGCAGCCTTTAAAGTTCGACAGGTCCTCTGGTAACGGTAAGTCAGTTTTATATAACCCTCCAATCGAAGAATTTGCTGTATTGGAGACTACTTTTGATGAGAAACTTGGTCAAAGGCATTTTGAAGGTGTTGATGGTCCAAGTATCTTAATCACTACAAAAGGTAATGGTTACATTAAAGCAGATGGCCAAAAATTGAAAGCTGAACCCGGTTTTGTCTTTTTCATCGCTCCACATTTGCCTGTTGATTTGGAAGCTGAAGATGAGGCGTTTACTACCTATAGAGCCTTTGTGGAACCAAATTAG","protein_sequence":"MSNKLFRLDAGYQQYDWGKIGSSSAVAQFAAHSDPSVQIEQDKPYAELWMGTHSKMPSYNHESKESLRDIISKNPSAMLGKDIIDKFHATNELPFLFKVLSIEKVLSIQAHPDKALGKILHAQDPKNYPDDNHKPEMAIAVTDFEGFCGFKPLQEIADELKRIPELRNIVGEETSRNFIENIQPSAQKGSPEDEQNKKLLQAVFSRVMNASDDKIKIQARSLVERSKNSPSDFNKPDLPELIQRLNKQFPDDVGLFCGCLLLNHCRLNAGEAIFLRAKDPHAYISGDIMECMAASDNVVRAGFTPKFKDVKNLVSMLTYTYDPVEKQKMQPLKFDRSSGNGKSVLYNPPIEEFAVLETTFDEKLGQRHFEGVDGPSILITTKGNGYIKADGQKLKAEPGFVFFIAPHLPVDLEAEDEAFTTYRAFVEPN"},{"created_at":"2011-05-27T05:29:18.000Z","updated_at":"2011-05-27T15:01:24.000Z","name":"Phosphomannomutase","uniprot_id":"P07283","uniprot_name":"PMM_YEAST","enzyme":true,"transporter":false,"gene_name":"SEC53","num_residues":254,"molecular_weight":"29062.69922","theoretical_pi":"4.88","general_function":"Involved in catalytic activity","specific_function":"Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions","reactions":[{"id":1876,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2774,"direction":"\u003e","locations":"Cytoplasm","altext":"Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3828,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006344","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AJ585720","genbank_protein_id":"45720044","gene_card_id":"SEC53","chromosome_location":"chromosome 6","locus":"YFL045C","synonyms":["PMM"],"enzyme_classes":["5.4.2.8"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular transferase activity"},{"category":"Function","description":" intramolecular transferase activity, phosphotransferases"},{"category":"Function","description":" phosphomannomutase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" mannose metabolic process"},{"category":"Process","description":" mannose biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PMM","identifier":"PF03332"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Mannose Metabolism","kegg_map_id":null}],"gene_sequence":"ATGAGTATCGCTGAATTCGCTTACAAGGAAAAACCAGAAACTTTGGTTTTATTCGATGTTGATGGTACCTTGACACCAGCCAGATTAACTGTTTCTGAAGAAGTTAGAAAAACTTTGGCCAAGTTGAGAAACAAGTGCTGCATTGGTTTTGTCGGTGGTTCTGACTTAAGCAAGCAATTAGAACAGTTAGGCCCAAACGTCTTAGATGAATTTGACTATTCTTTCTCTGAAAATGGTTTGACCGCCTACAGATTAGGTAAGGAATTAGCTTCTCAATCCTTCATCAACTGGCTCGGTGAGGAAAAATACAATAAATTGGCCGTCTTCATTTTGAGATATCTATCTGAAATTGACTTGCCAAAGAGAAGAGGTACTTTCTTGGAATTTAGAAATGGTATGATCAACGTTTCCCCAATTGGTAGAAATGCTTCTACTGAGGAAAGAAACGAATTCGAAAGATACGATAAGGAACACCAAATCAGAGCTAAGTTCGTTGAAGCTTTGAAAAAGGAATTCCCAGACTACGGTTTGACTTTCTCCATTGGTGGCCAAATCTCTTTCGACGTTTTCCCCGCTGGTTGGGATAAGACCTACTGTTTGCAACACGTTGAAAAAGATGGTTTCAAGGAAATTCATTTCTTTGGTGACAAGACTATGGTCGGTGGTAACGATTACGAAATTTTTGTCGATGAAAGAACCATCGGACATTCAGTACAATCTCCTGATGACACCGTCAAAATTTTGACTGAACTATTCAACTTATAG","protein_sequence":"MSIAEFAYKEKPETLVLFDVDGTLTPARLTVSEEVRKTLAKLRNKCCIGFVGGSDLSKQLEQLGPNVLDEFDYSFSENGLTAYRLGKELASQSFINWLGEEKYNKLAVFILRYLSEIDLPKRRGTFLEFRNGMINVSPIGRNASTEERNEFERYDKEHQIRAKFVEALKKEFPDYGLTFSIGGQISFDVFPAGWDKTYCLQHVEKDGFKEIHFFGDKTMVGGNDYEIFVDERTIGHSVQSPDDTVKILTELFNL"}]}