{"ymdb_id":"YMDB00175","created_at":"2011-05-29T16:03:56.000Z","updated_at":"2016-10-18T17:11:19.000Z","name":"Pyruvic acid","cas":"127-17-3","state":"Liquid","melting_point":"13.8 oC","description":"Pyruvic acid is an organic acid, a ketone, as well as the simplest of the alpha-keto acids. The carboxylate (COOH) ion (anion) of pyruvic acid is known as pyruvate, and is a key intersection in several metabolic pathways. It can be made from glucose through glycolysis, converted back to carbohydrates (such as glucose) via gluconeogenesis, or to fatty acids through acetyl-CoA. It can also be used to construct the amino acid alanine and be converted into ethanol. It supplies energy to living cells through the citric acid cycle when oxygen is present (aerobic respiration), and alternatively ferments to produce lactate when oxygen is lacking (fermentation). [Wikipedia]","experimental_water_solubility":"1000 mg/mL at 20 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":null,"location":"Cytoplasm;Extracellular;Mitochondrion;Peroxisome","synthesis_reference":"Xiang, Wei; Okita, Motomu.  Preparation of pyruvic acid.    Jpn. Kokai Tokkyo Koho  (2003),     5 pp.","chebi_id":"32816","hmdb_id":"HMDB00243","kegg_id":"C00022","pubchem_id":"1060","cs_id":"1031","foodb_id":null,"wikipedia_link":"Pyruvic_acid","biocyc_id":"PYRUVATE","iupac":"2-oxopropanoic acid","traditional_iupac":"pyruvic acid","logp":"0.06587395333333337","pka":null,"alogps_solubility":"1.34e+02 g/l","alogps_logp":"-0.38","alogps_logs":"0.18","acceptor_count":"3","donor_count":"1","rotatable_bond_count":"1","polar_surface_area":"54.37","refractivity":"17.9897","polarizability":"7.310505872988212","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-9.583170381128017","pka_strongest_acidic":"2.93012330309767","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-ketopropionic acid","2-Oxopropanoate","2-Oxopropanoic acid","2-Oxopropionate","2-Oxopropionic acid","a-Ketopropionate","a-Ketopropionic acid","Acetylformate","Acetylformic acid","alpha-Ketopropionate","alpha-Ketopropionic acid","BTS","Propanoic acid, 2-oxo-","Pyroracemate","Pyroracemic acid","Pyruvate","pyruvic acid"],"pathways":[{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Thiamine metabolism","kegg_map_id":"00730"},{"name":"Terpenoid backbone biosynthesis","kegg_map_id":"00900"},{"name":"Taurine and hypotaurine metabolism","kegg_map_id":"00430"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Vitamin B6 metabolism","kegg_map_id":"00750"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"Pentose and glucuronate interconversions","kegg_map_id":"00040"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Citric Acid Cycle","kegg_map_id":null},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Ethanol fermentation","kegg_map_id":null},{"name":"Glycolysis I","kegg_map_id":null},{"name":"L-alanine metabolism","kegg_map_id":null},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Sulfur metabolism","kegg_map_id":"00920"},{"name":"TCA Cycle","kegg_map_id":null},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Valine Biosynthesis","kegg_map_id":null},{"name":"Vitamin B6","kegg_map_id":null},{"name":"glycine metabolism","kegg_map_id":null},{"name":"isoleucine biosynthesis","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"growth_conditions":[{"growth_media":"hops, malted barley","concentration":"1771.0","concentration_units":"\u0026#181;M","error":"273.0"},{"growth_media":"20 ml 2% (wt/vol) glucose, 0.5% (wt/vol) ammonium sulfate, 0.17% (wt/vol) yeast nitrogen base\rwithout amino acids (Difco, Detroit, MI) and 100 mM potassium phthalate at\rpH 5.0, supplemented with required nutrients (40 mg/L uracil, 40 mg/L Ltryptophan,\r60 ","concentration":"3390.0","concentration_units":"\u0026#181;M","error":"540.0"},{"growth_media":"YEB media with 0.5 mM glucose","concentration":"3380.0","concentration_units":"\u0026#181;M","error":"169.0"},{"growth_media":"Synthetic medium with 20 g/L glucose","concentration":"118.0","concentration_units":"\u0026#181;M","error":"20.0"},{"growth_media":"Minimal medium  supplemented with ammonia salts","concentration":"130.0","concentration_units":"\u0026#181;M","error":"0.0"},{"growth_media":"Minimal medium  supplemented with ammonia salts and glucose","concentration":"140.0","concentration_units":"\u0026#181;M","error":"80.0"},{"growth_media":"Minimal medium supplemented with ammonia salts and (glucose or galactose)","concentration":"5250.0","concentration_units":"\u0026#181;M","error":"4750.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"1600.0","concentration_units":"\u0026#181;M","error":"10.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"440.0","concentration_units":"\u0026#181;M","error":"40.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"340.0","concentration_units":"\u0026#181;M","error":"110.0"},{"growth_media":"Synthetic medium with 2% galactose","concentration":"1300.0","concentration_units":"\u0026#181;M","error":"300.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":11135551,"citation":"Raamsdonk, L. M., Teusink, B., Broadhurst, D., Zhang, N., Hayes, A., Walsh, M. C., Berden, J. A., Brindle, K. M., Kell, D. B., Rowland, J. J., Westerhoff, H. V., van Dam, K., Oliver, S. G. (2001). \"A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations.\" Nat Biotechnol 19:45-50."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":4616942,"citation":"Ryan, E. D., Kohlhaw, G. B. (1974). \"Subcellular localization of isoleucine-valine biosynthetic enzymes in yeast.\" J Bacteriol 120:631-637."},{"pubmed_id":9746941,"citation":"Goncalves, P., Planta, R. J. (1998). \"Starting up yeast glycolysis.\" Trends Microbiol 6:314-319."},{"pubmed_id":11092862,"citation":"Luttik, M. A., Kotter, P., Salomons, F. A., van der Klei, I. J., van Dijken, J. P., Pronk, J. T. (2000). \"The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism.\" J Bacteriol 182:7007-7013."},{"pubmed_id":7878741,"citation":"Thevelein, J. M., Hohmann, S. (1995). \"Trehalose synthase: guard to the gate of glycolysis in yeast?\" Trends Biochem Sci 20:3-10."},{"pubmed_id":16584566,"citation":"Schwartz, J. M., Kanehisa, M. (2006). \"Quantitative elementary mode analysis of metabolic pathways: the example of yeast glycolysis.\" BMC Bioinformatics 7:186."},{"pubmed_id":3933486,"citation":"Takada, Y., Noguchi, T. (1985). \"Characteristics of alanine: glyoxylate aminotransferase from Saccharomyces cerevisiae, a regulatory enzyme in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates.\" Biochem J 231:157-163."},{"pubmed_id":16448171,"citation":"Almeida, C., Duarte, I. F., Barros, A., Rodrigues, J., Spraul, M., Gil, A. M. (2006). \"Composition of beer by 1H NMR spectroscopy: effects of brewing site and date of production.\" J Agric Food Chem 54:700-706."},{"pubmed_id":12584756,"citation":"Hans, M. A., Heinzle, E., Wittmann, C. (2003). \"Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae.\" Biotechnol Bioeng 82:143-151."},{"pubmed_id":16348083,"citation":"Senac, T., Hahn-Hagerdal, B. (1990). \"Intermediary Metabolite Concentrations in Xylulose- and Glucose-Fermenting Saccharomyces cerevisiae Cells.\" Appl Environ Microbiol 56:120-126."},{"pubmed_id":8001582,"citation":"Crombie, T., Boyle, J. P., Coggins, J. R., Brown, A. J. (1994). \"The folding of the bifunctional TRP3 protein in yeast is influenced by a translational pause which lies in a region of structural divergence with Escherichia coli indoleglycerol-phosphate synthase.\" Eur J Biochem 226:657-664."},{"pubmed_id":16332871,"citation":"Singh, J., Kumar, D., Ramakrishnan, N., Singhal, V., Jervis, J., Garst, J. F., Slaughter, S. M., DeSantis, A. M., Potts, M., Helm, R. F. (2005). \"Transcriptional response of Saccharomyces cerevisiae to desiccation and rehydration.\" Appl Environ Microbiol 71:8752-8763."},{"pubmed_id":6185493,"citation":"Burke, R. L., Tekamp-Olson, P., Najarian, R. (1983). \"The isolation, characterization, and sequence of the pyruvate kinase gene of Saccharomyces cerevisiae.\" J Biol Chem 258:2193-2201."},{"pubmed_id":12902239,"citation":"Vuralhan, Z., Morais, M. A., Tai, S. L., Piper, M. D., Pronk, J. T. (2003). \"Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae.\" Appl Environ Microbiol 69:4534-4541."},{"pubmed_id":8972574,"citation":"Cullin, C., Baudin-Baillieu, A., Guillemet, E., Ozier-Kalogeropoulos, O. (1996). \"Functional analysis of YCL09C: evidence for a role as the regulatory subunit of acetolactate synthase.\" Yeast 12:1511-1518."},{"pubmed_id":4578278,"citation":"Gancedo, J. M., Gancedo, C. (1973). \"Concentrations of intermediary metabolites in yeast.\" Biochimie 55:205-211."},{"pubmed_id":6229402,"citation":"Lagunas, R., Gancedo, C. (1983). \"Role of phosphate in the regulation of the Pasteur effect in Saccharomyces cerevisiae.\" Eur J Biochem 137:479-483."}],"proteins":[{"created_at":"2011-05-24T19:23:19.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"Anthranilate synthase component 2","uniprot_id":"P00937","uniprot_name":"TRPG_YEAST","enzyme":true,"transporter":false,"gene_name":"TRP3","num_residues":484,"molecular_weight":"53488.89844","theoretical_pi":"6.91","general_function":"Involved in catalytic activity","specific_function":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate","reactions":[{"id":1657,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2251,"direction":"\u003e","locations":"","altext":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2252,"direction":"\u003e","locations":null,"altext":"1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":14103,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006527","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"K01386","genbank_protein_id":"173045","gene_card_id":"TRP3","chromosome_location":"chromosome 11","locus":"YKL211C","synonyms":["Anthranilate synthase component II","Glutamine amidotransferase","Indole-3-glycerol phosphate synthase","PRAI"],"enzyme_classes":["4.1.3.27","4.1.1.48"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" indole-3-glycerol-phosphate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" anthranilate synthase activity"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" indolalkylamine metabolic process"},{"category":"Process","description":" tryptophan metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glutamine metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"IGPS","identifier":"PF00218"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGTCTGTGCACGCTGCAACAAACCCAATCAATAAGCATGTGGTTCTAATTGACAACTACGATTCCTTTACCTGGAACGTTTACGAGTACTTGTGCCAGGAGGGCGCCAAAGTGAGCGTCTACCGTAACGATGCAATTACAGTTCCAGAAATTGCCGCCTTGAATCCCGACACATTGCTTATCTCGCCTGGACCAGGCCACCCAAAGACAGATTCTGGCATTTCAAGAGACTGTATCCGGTACTTTACTGGGAAAATTCCTGTATTTGGAATCTGTATGGGCCAGCAATGCATGTTTGACGTATTTGGTGGTGAAGTTGCCTACGCTGGTGAGATTGTCCACGGTAAAACGTCCCCAATCTCTCACGACAACTGTGGAATTTTCAGGAACGTGCCGCAAGGTATTGCTGTGACAAGATACCATTCATTGGCCGGGACAGAATCGTCCCTACCATCCTGCTTGAAGGTTACTGCGAGTACCGAAAATGGAATTATCATGGGTGTAAGACACAAGAAGTACACTGTAGAAGGTGTGCAATTTCATCCGGAATCCATCTTGACCGAGGAAGGTCATCTGATGATCAGGAACATTTTAAACGTCAGTGGAGGCACTTGGGAGGAAAACAAATCATCTCCTTCAAATTCTATTTTGGACCGTATCTATGCTCGGCGTAAAATAGACGTCAATGAGCAGTCTAAAATCCCAGGTTTCACCTTTCAAGACTTACAATCTAACTATGATTTAGGTCTTGCCCCACCGTTACAGGATTTCTACACGGTGTTGTCATCATCCCATAAAAGAGCCGTTGTTCTTGCTGAAGTCAAGCGTGCCTCTCCATCGAAGGGACCCATTTGTTTAAAAGCTGTTGCTGCTGAACAGGCTCTCAAATACGCAGAGGCTGGTGCATCCGCAATTTCCGTATTGACCGAACCTCATTGGTTTCACGGTTCGTTACAGGATTTAGTAAATGTGAGGAAAATCCTAGATTTGAAATTTCCTCCCAAGGAGAGGCCTTGTGTTTTGAGAAAAGAATTTATTTTCAGCAAGTATCAAATACTAGAAGCAAGATTAGCTGGAGCTGACACTGTCCTTCTTATAGTCAAGATGCTATCTCAACCCTTATTGAAGGAACTGTACAGCTACAGTAAAGATTTGAACATGGAACCTCTCGTTGAGGTGAACTCCAAAGAGGAATTACAAAGGGCTCTAGAAATTGGTGCTAAAGTTGTAGGTGTCAATAATAGGGACCTGCATTCATTCAACGTAGACCTAAATACCACCAGTAACTTGGTAGAATCTATTCCAAAGGATGTTCTTCTAATTGCTCTATCGGGAATTACCACCAGGGACGATGCTGAAAAATACAAAAAAGAAGGTGTCCATGGATTTTTAGTGGGTGAAGCCCTAATGAAATCAACCGATGTGAAGAAGTTCATTCATGAATTATGCGAATAA","protein_sequence":"MSVHAATNPINKHVVLIDNYDSFTWNVYEYLCQEGAKVSVYRNDAITVPEIAALNPDTLLISPGPGHPKTDSGISRDCIRYFTGKIPVFGICMGQQCMFDVFGGEVAYAGEIVHGKTSPISHDNCGIFKNVPQGIAVTRYHSLAGTESSLPSCLKVTASTENGIIMGVRHKKYTVEGVQFHPESILTEEGHLMIRNILNVSGGTWEENKSSPSNSILDRIYARRKIDVNEQSKIPGFTFQDLQSNYDLGLAPPLQDFYTVLSSSHKRAVVLAEVKRASPSKGPICLKAVAAEQALKYAEAGASAISVLTEPHWFHGSLQDLVNVRKILDLKFPPKERPCVLRKEFIFSKYQILEARLAGADTVLLIVKMLSQPLLKELYSYSKDLNMEPLVEVNSKEELQRALEIGAKVVGVNNRDLHSFNVDLNTTSNLVESIPKDVLLIALSGITTRDDAEKYKKEGVHGFLVGEALMKSTDVKKFIHELCE"},{"created_at":"2011-05-24T19:34:32.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Anthranilate synthase component 1","uniprot_id":"P00899","uniprot_name":"TRPE_YEAST","enzyme":true,"transporter":false,"gene_name":"TRP2","num_residues":507,"molecular_weight":"56767.0","theoretical_pi":"5.65","general_function":"Involved in biosynthetic process","specific_function":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate","reactions":[{"id":2251,"direction":"\u003e","locations":"","altext":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":14103,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006527","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U18839","genbank_protein_id":"603328","gene_card_id":"TRP2","chromosome_location":"chromosome 5","locus":"YER090W","synonyms":["Anthranilate synthase component I"],"enzyme_classes":["4.1.3.27"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" anthranilate synthase activity"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" indolalkylamine metabolic process"},{"category":"Process","description":" tryptophan metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" tryptophan biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Anth_synt_I_N","identifier":"PF04715"},{"name":"Chorismate_bind","identifier":"PF00425"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACCGCTTCCATCAAAATTCAACCGGATATTGACTCTCTAAAGCAATTACAGCAGCAAAATGACGATAGTTCCATAAATATGTATCCCGTGTATGCGTATTTGCCATCATTGGATCTGACTCCTCACGTGGCATATCTAAAATTGGCACAATTGAACAACCCTGATAGAAAGGAATCATTTCTGTTGGAAAGTGCTAAGACAAATAATGAATTAGATCGTTATTCATTCATAGGTATCTCGCCACGCAAGACCATCAAAACCGGTCCTACTGAAGGCATTGAAACAGATCCTTTGGAAATTTTGGAAAAGGAGATGTCTACCTTTAAAGTAGCCGAAAATGTTCCTGGTTTACCGAAATTAAGTGGTGGTGCTATTGGTTATATTTCTTATGACTGTGTTCGTTATTTCGAGCCAAAAACAAGAAGGCCTTTGAAAGATGTCCTAAGACTTCCAGAGGCATATTTAATGCTTTGTGATACCATTATTGCCTTTGATAATGTTTTTCAGAGATTTCAAATCATTCATAACATTAATACCAATGAAACTTCGTTGGAGGAAGGTTACCAAGCTGCAGCACAAATAATCACTGATATCGTATCAAAGCTAACCGACGATTCCTCGCCAATACCATATCCAGAACAACCTCCTATTAAATTGAATCAAACTTTTGAATCGAATGTGGGCAAGGAAGGTTACGAAAATCACGTCTCCACTTTGAAGAAGCATATTAAGAAAGGTGATATTATTCAAGGTGTGCCATCGCAAAGAGTGGCAAGGCCAACTTCGTTACATCCTTTCAATATTTACAGACATTTACGTACAGTGAACCCATCTCCTTACCTGTTTTATATTGATTGTTTGGATTTCCAAATCATTGGTGCATCTCCAGAATTGTTGTGCAAATCGGATTCCAAAAATAGAGTCATTACCCATCCAATTGCTGGTACTGTCAAACGTGGGGCTACTACTGAAGAGGATGATGCTTTAGCGGACCAATTACGTGGCTCGTTAAAAGACCGTGCAGAACATGTTATGCTGGTAGATTTAGCAAGAAACGATATTAACAGAATTTGTGACCCATTAACAACAAGTGTCGATAAACTGTTAACTATTCAAAAATTTTCTCATGTCCAACATCTGGTTTCTCAAGTCAGCGGTGTTCTCCGCCCAGAAAAGACAAGATTTGATGCATTCAGATCGATTTTCCCTGCAGGTACTGTCAGTGGTGCTCCAAAGGTTAGAGCCATGGAATTGATTGCCGAACTAGAAGGAGAAAGGCGTGGGGTTTATGCAGGCGCCGTAGGTCATTGGTCATACGACGGTAAAACAATGGACAATTGTATCGCTTTAAGGACTATGGTCTATAAAGATGGCATTGCTTACTTGCAAGCTGGCGGTGGTATTGTTTACGATTCAGATGAGTACGATGAATATGTCGAAACCATGAATAAAATGATGGCCAATCACAGTACTATTGTGCAAGCAGAAGAATTGTGGGCCGATATCGTAGGATCAGCTTAA","protein_sequence":"MTASIKIQPDIDSLKQLQQQNDDSSINMYPVYAYLPSLDLTPHVAYLKLAQLNNPDRKESFLLESAKTNNELDRYSFIGISPRKTIKTGPTEGIETDPLEILEKEMSTFKVAENVPGLPKLSGGAIGYISYDCVRYFEPKTRRPLKDVLRLPEAYLMLCDTIIAFDNVFQRFQIIHNINTNETSLEEGYQAAAQIITDIVSKLTDDSSPIPYPEQPPIKLNQTFESNVGKEGYENHVSTLKKHIKKGDIIQGVPSQRVARPTSLHPFNIYRHLRTVNPSPYLFYIDCLDFQIIGASPELLCKSDSKNRVITHPIAGTVKRGATTEEDDALADQLRGSLKDRAEHVMLVDLARNDINRICDPLTTSVDKLLTIQKFSHVQHLVSQVSGVLRPEKTRFDAFRSIFPAGTVSGAPKVRAMELIAELEGERRGVYAGAVGHWSYDGKTMDNCIALRTMVYKDGIAYLQAGGGIVYDSDEYDEYVETMNKMMANHSTIVQAEELWADIVGSA"},{"created_at":"2011-05-24T19:55:26.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Probable kynurenine--oxoglutarate transaminase BNA3","uniprot_id":"P47039","uniprot_name":"BNA3_YEAST","enzyme":true,"transporter":false,"gene_name":"BNA3","num_residues":444,"molecular_weight":"50081.89844","theoretical_pi":"6.53","general_function":"Involved in 1-aminocyclopropane-1-carboxylate synthase activity","specific_function":"Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA)","reactions":[{"id":1756,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2282,"direction":"\u003e","locations":"Cytoplasm. Mitochondrion","altext":"L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3723,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006249","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Mitochondrion","genbank_gene_id":"Z49335","genbank_protein_id":"1008205","gene_card_id":"BNA3","chromosome_location":"chromosome 10","locus":"YJL060W","synonyms":["Biosynthesis of nicotinic acid protein 3","Kynurenine aminotransferase"],"enzyme_classes":["2.6.1.7"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" carbon-sulfur lyase activity"},{"category":"Function","description":" 1-aminocyclopropane-1-carboxylate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" lyase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"L-alanine metabolism","kegg_map_id":null}],"gene_sequence":"ATGAAACAACGATTCATTCGTCAATTTACGAACCTAATGTCTACTTCGAGACCGAAAGTTGTTGCCAACAAATATTTCACTTCTAACACTGCCAAAGATGTTTGGTCGCTAACCAATGAAGCCGCTGCAAAAGCTGCCAATAACTCCAAAAACCAAGGCCGTGAACTTATTAATTTAGGCCAAGGCTTTTTTTCATATTCCCCTCCTCAATTCGCCATTAAGGAGGCTCAGAAAGCCCTAGACATTCCAATGGTCAATCAATATTCTCCAACTAGAGGTCGACCTTCATTAATTAATTCCTTGATTAAGTTGTATTCTCCTATTTATAACACAGAATTGAAAGCGGAAAATGTTACCGTAACAACAGGTGCCAATGAAGGTATACTTTCTTGCTTGATGGGGCTTTTGAACGCTGGCGACGAGGTTATTGTTTTTGAACCTTTCTTTGACCAATATATTCCAAATATCGAACTTTGCGGTGGTAAAGTTGTTTACGTCCCCATAAATCCTCCAAAGGAATTGGATCAAAGGAATACTAGAGGTGAAGAATGGACCATTGACTTTGAGCAGTTCGAAAAAGCGATTACATCCAAGACAAAAGCTGTCATTATCAATACCCCTCACAACCCAATTGGTAAAGTTTTCACGCGCGAGGAATTAACCACTTTAGGTAACATTTGCGTCAAGCACAACGTTGTGATTATATCTGATGAAGTCTATGAACACCTTTACTTCACTGATTCTTTCACTAGAATTGCCACACTCTCTCCAGAAATTGGGCAACTAACCTTAACGGTCGGTTCTGCCGGTAAATCGTTTGCTGCTACTGGTTGGAGAATTGGTTGGGTCTTATCCTTGAACGCAGAGTTGTTAAGTTATGCAGCTAAGGCACATACAAGAATTTGTTTTGCATCTCCATCCCCTCTACAGGAAGCTTGTGCAAACTCTATTAACGACGCTTTAAAAATTGGGTATTTTGAAAAAATGAGACAGGAATATATCAACAAATTCAAAATTTTCACATCGATCTTTGATGAATTGGGACTACCATATACAGCTCCAGAGGGTACATATTTTGTCCTCGTTGATTTCTCTAAAGTGAAAATTCCCGAGGACTATCCCTACCCAGAGGAGATCCTGAATAAGGGAAAAGATTTTCGCATTTCTCACTGGTTGATCAATGAATTAGGTGTGGTTGCCATTCCACCAACTGAATTCTATATCAAAGAGCACGAAAAGGCTGCTGAGAATTTGTTAAGGTTTGCAGTTTGTAAAGATGATGCTTATCTAGAAAATGCCGTAGAGAGATTAAAACTACTCAAGGACTACTTATAA","protein_sequence":"MKQRFIRQFTNLMSTSRPKVVANKYFTSNTAKDVWSLTNEAAAKAANNSKNQGRELINLGQGFFSYSPPQFAIKEAQKALDIPMVNQYSPTRGRPSLINSLIKLYSPIYNTELKAENVTVTTGANEGILSCLMGLLNAGDEVIVFEPFFDQYIPNIELCGGKVVYVPINPPKELDQRNTRGEEWTIDFEQFEKAITSKTKAVIINTPHNPIGKVFTREELTTLGNICVKHNVVIISDEVYEHLYFTDSFTRIATLSPEIGQLTLTVGSAGKSFAATGWRIGWVLSLNAELLSYAAKAHTRICFASPSPLQEACANSINDALKIGYFEKMRQEYINKFKIFTSIFDELGLPYTAPEGTYFVLVDFSKVKIPEDYPYPEEILNKGKDFRISHWLINELGVVAIPPTEFYIKEHEKAAENLLRFAVCKDDAYLENAVERLKLLKDYL"},{"created_at":"2011-05-24T20:10:13.000Z","updated_at":"2011-07-22T17:54:01.000Z","name":"Alanine--glyoxylate aminotransferase 1","uniprot_id":"P43567","uniprot_name":"AGX1_YEAST","enzyme":true,"transporter":false,"gene_name":"AGX1","num_residues":385,"molecular_weight":"41906.80078","theoretical_pi":"8.14","general_function":"Involved in metabolic process","specific_function":"Has alanine:glyoxylate aminotransferase activity","reactions":[{"id":1284,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2302,"direction":"\u003e","locations":null,"altext":"L-alanine + glyoxylate = pyruvate + glycine.","export":false,"pw_reaction_id":null,"source":null},{"id":3853,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006374","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D50617","genbank_protein_id":"836724","gene_card_id":"AGX1","chromosome_location":"chromosome 6","locus":"YFL030W","synonyms":[],"enzyme_classes":["2.6.1.44"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Aminotran_5","identifier":"PF00266"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"glycine metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTAAATCTGTAGATACGCTGCTGATCCCAGGCCCCATTATCCTAAGCGGAGCAGTCCAGAAGGCCCTGGACGTTCCCTCTTTGGGCCACACCTCTCCTGAGTTCGTCTCTATTTTTCAAAGGGTGCTAAAGAACACAAGAGCTGTCTTCAAATCCGCTGCTGCCTCGAAGTCTCAGCCTTTTGTGCTTGCCGGCTCTGGTACGTTGGGGTGGGACATATTTGCCTCGAACTTTATTCTTTCGAAGGCCCCCAACAAGAACGTGCTGGTCGTATCCACTGGGACATTTTCTGACAGGTTTGCTGACTGTCTGCGTAGCTACGGTGCGCAAGTAGATGTTGTTAGGCCCCTCAAGATAGGCGAATCAGTTCCCTTAGAACTGATTACTGAAAAGTTGTCGCAAAATAGCTATGGGGCTGTCACGGTTACGCACGTTGACACTTCAACGGCAGTGCTGTCCGATCTGAAAGCCATTTCGCAAGCGATTAAGCAGACTTCGCCGGAAACGTTCTTCGTAGTCGATGCTGTATGCTCGATTGGATGCGAAGAGTTTGAATTTGATGAATGGGGGGTGGATTTCGCCTTGACTGCTTCGCAAAAGGCTATTGGCGCTCCAGCGGGTCTTTCTATCTCGCTATGCAGTAGCAGATTCATGGATTATGCACTCAACGACAGCAAAAATGGTCATGTACATGGGTATTTTTCCTCGTTGAGAAGATGGACACCAATAATGGAAAATTATGAGGCTGGTAAAGGAGCTTATTTTGCAACCCCACCCGTACAACTAATTAATAGCCTTGATGTAGCCTTGAAAGAAATTCTCGAAGAGGGGTTGCATAAGAGATGGGATTTGCACCGTGAAATGAGTGATTGGTTTAAAGACAGTTTGGTTAATGGCTTGCAATTGACATCCGTCAGTAGGTATCCTTCTAACATGTCTGCGCACGGGTTGACAGCCGTATACGTAGCAGATCCTCCTGATGTCATTGCTTTTTTAAAGTCACACGGTGTAGTCATTGCCGGAGGTATTCACAAGGACATCGGACCCAAGTATATCCGTATTGGACATATGGGTGTGACCGCTTGCAACAAGAATTTACCGTACATGAAGAACTGCTTCGACTTAATAAAACTAGCTCTTCAGAGGAAAAAGTGA","protein_sequence":"MTKSVDTLLIPGPIILSGAVQKALDVPSLGHTSPEFVSIFQRVLKNTRAVFKSAAASKSQPFVLAGSGTLGWDIFASNFILSKAPNKNVLVVSTGTFSDRFADCLRSYGAQVDVVRPLKIGESVPLELITEKLSQNSYGAVTVTHVDTSTAVLSDLKAISQAIKQTSPETFFVVDAVCSIGCEEFEFDEWGVDFALTASQKAIGAPAGLSISLCSSRFMDYALNDSKNGHVHGYFSSLRRWTPIMENYEAGKGAYFATPPVQLINSLDVALKEILEEGLHKRWDLHREMSDWFKDSLVNGLQLTSVSRYPSNMSAHGLTAVYVADPPDVIAFLKSHGVVIAGGIHKDIGPKYIRIGHMGVTACNKNLPYMKNCFDLIKLALQRKK"},{"created_at":"2011-05-24T20:14:31.000Z","updated_at":"2011-05-27T14:56:00.000Z","name":"Dihydrolipoyl dehydrogenase, mitochondrial","uniprot_id":"P09624","uniprot_name":"DLDH_YEAST","enzyme":true,"transporter":false,"gene_name":"LPD1","num_residues":499,"molecular_weight":"54009.69922","theoretical_pi":"8.22","general_function":"Involved in oxidoreductase activity","specific_function":"Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine","reactions":[{"id":2306,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1V59","cellular_location":"Mitochondrion matrix","genbank_gene_id":"D50617","genbank_protein_id":"836736","gene_card_id":"LPD1","chromosome_location":"chromosome 6","locus":"YFL018C","synonyms":["Dihydrolipoamide dehydrogenase","Glycine decarboxylase complex subunit L","Lipoamide dehydrogenase component of pyruvate dehydrogenase complex","Pyruvate dehydrogenase complex E3 component"],"enzyme_classes":["1.8.1.4"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on NADH or NADPH"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" dihydrolipoyl dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" cell redox homeostasis"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Pyr_redox","identifier":"PF00070"},{"name":"Pyr_redox_2","identifier":"PF07992"},{"name":"Pyr_redox_dim","identifier":"PF02852"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"}],"gene_sequence":"ATGTTAAGAATCAGATCACTCCTAAATAATAAGCGTGCCTTTTCGTCCACAGTCAGGACATTGACCATTAACAAGTCACATGATGTAGTCATCATCGGTGGTGGCCCTGCTGGTTACGTGGCTGCTATCAAAGCTGCTCAATTGGGATTTAACACTGCATGTGTAGAAAAAAGAGGCAAATTAGGCGGTACCTGTCTTAACGTTGGATGTATCCCCTCCAAAGCACTTCTAAATAATTCTCATTTATTCCACCAAATGCATACGGAAGCGCAAAAGAGAGGTATTGACGTCAACGGTGATATCAAAATTAACGTAGCAAACTTCCAAAAGGCTAAGGATGACGCTGTTAAGCAATTAACTGGAGGTATTGAGCTTCTGTTCAAGAAAAATAAGGTCACCTATTATAAAGGTAATGGTTCATTCGAAGACGAAACGAAGATCAGAGTAACTCCCGTTGATGGGTTGGAAGGCACTGTCAAGGAAGACCACATACTAGATGTTAAGAACATCATAGTCGCCACGGGCTCTGAAGTTACACCCTTCCCCGGTATTGAAATAGATGAGGAAAAAATTGTCTCTTCAACAGGTGCTCTTTCGTTAAAGGAAATTCCCAAAAGATTAACCATCATTGGTGGAGGAATCATCGGATTGGAAATGGGTTCAGTTTACTCTAGATTAGGCTCCAAGGTTACTGTAGTAGAATTTCAACCTCAAATTGGTGCATCTATGGACGGCGAGGTTGCCAAAGCCACCCAAAAGTTCTTGAAAAAGCAAGGTTTGGACTTCAAATTAAGCACCAAAGTTATTTCTGCAAAGAGAAACGACGACAAGAACGTCGTCGAAATTGTTGTAGAAGATACTAAAACGAATAAGCAAGAAAATTTGGAAGCTGAAGTTTTGCTGGTTGCTGTTGGTAGAAGACCTTACATTGCTGGCTTAGGGGCTGAAAAGATTGGATTAGAAGTAGACAAAAGGGGACGCCTAGTCATTGATGACCAATTTAATTCCAAGTTCCCACACATTAAAGTGGTAGGAGATGTTACATTTGGTCCAATGCTGGCTCACAAAGCCGAAGAGGAAGGTATTGCAGCTGTCGAAATGTTGAAAACTGGTCACGGTCATGTCAACTATAACAACATTCCTTCGGTCATGTATTCTCACCCAGAAGTAGCATGGGTTGGTAAAACCGAAGAGCAATTGAAAGAAGCCGGCATTGACTATAAAATTGGTAAGTTCCCCTTTGCGGCCAATTCAAGAGCCAAGACCAACCAAGACACTGAAGGTTTCGTGAAGATTTTGATCGATTCCAAGACCGAGCGTATTTTGGGGGCTCACATTATCGGTCCAAATGCCGGTGAAATGATTGCTGAAGCTGGCTTAGCCTTAGAATATGGCGCTTCCGCAGAAGATGTTGCTAGGGTCTGCCATGCTCATCCTACTTTGTCCGAAGCATTTAAGGAAGCTAACATGGCTGCCTATGATAAAGCTATTCATTGTTGA","protein_sequence":"MLRIRSLLNNKRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC"},{"created_at":"2011-05-24T20:26:42.000Z","updated_at":"2011-07-22T17:53:52.000Z","name":"Pyruvate decarboxylase isozyme 2","uniprot_id":"P16467","uniprot_name":"PDC5_YEAST","enzyme":true,"transporter":false,"gene_name":"PDC5","num_residues":563,"molecular_weight":"61911.60156","theoretical_pi":"6.4","general_function":"Involved in magnesium ion binding","specific_function":"Second most abundant of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids valine, isoleucine, phenylalanine, and tryptophan, whereas leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins","reactions":[{"id":1184,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1186,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1228,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1658,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1841,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1933,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1934,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2319,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm;Nucleus","altext":"A 2-oxo acid = an aldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2320,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2321,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Phenylpyruvate = phenylacetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2322,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Pyruvate = Acetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2323,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"A 2-oxo acid + an aldehyde = A 2-hydroxy ketone + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2324,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"An aldehyde + an aldehyde = A 2-hydroxy ketone.","export":false,"pw_reaction_id":null,"source":null},{"id":14096,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006520","source":"Smpdb"},{"id":14097,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006525","source":"Smpdb"},{"id":14098,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006537","source":"Smpdb"},{"id":14099,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006557","source":"Smpdb"},{"id":14100,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006971","source":"Smpdb"},{"id":14101,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006979","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U53881","genbank_protein_id":"1256902","gene_card_id":"PDC5","chromosome_location":"chromosome 12","locus":"YLR134W","synonyms":[],"enzyme_classes":["4.1.1.-","4.1.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" thiamin pyrophosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TPP_enzyme_C","identifier":"PF02775"},{"name":"TPP_enzyme_M","identifier":"PF00205"},{"name":"TPP_enzyme_N","identifier":"PF02776"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Ethanol fermentation","kegg_map_id":null},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Valine Degradation","kegg_map_id":null}],"gene_sequence":"ATGTCTGAAATAACCTTAGGTAAATATTTATTTGAAAGATTGAGCCAAGTCAACTGTAACACCGTCTTCGGTTTGCCAGGTGACTTTAACTTGTCTCTTTTGGATAAGCTTTATGAAGTCAAAGGTATGAGATGGGCTGGTAACGCTAACGAATTGAACGCTGCCTATGCTGCTGATGGTTACGCTCGTATCAAGGGTATGTCCTGTATTATTACCACCTTCGGTGTTGGTGAATTGTCTGCTTTGAATGGTATTGCCGGTTCTTACGCTGAACATGTCGGTGTTTTGCACGTTGTTGGTGTTCCATCCATCTCTTCTCAAGCTAAGCAATTGTTGTTGCATCATACCTTGGGTAACGGTGACTTCACTGTTTTCCACAGAATGTCTGCCAACATTTCTGAAACCACTGCCATGATCACTGATATTGCTAACGCTCCAGCTGAAATTGACAGATGTATCAGAACCACCTACACTACCCAAAGACCAGTCTACTTGGGTTTGCCAGCTAACTTGGTTGACTTGAACGTCCCAGCCAAGTTATTGGAAACTCCAATTGACTTGTCTTTGAAGCCAAACGACGCTGAAGCTGAAGCTGAAGTTGTTAGAACTGTTGTTGAATTGATCAAGGATGCTAAGAACCCAGTTATCTTGGCTGATGCTTGTGCTTCTAGACATGATGTCAAGGCTGAAACTAAGAAGTTGATGGACTTGACTCAATTCCCAGTTTACGTCACCCCAATGGGTAAGGGTGCTATTGACGAACAACACCCAAGATACGGTGGTGTTTACGTTGGTACCTTGTCTAGACCAGAAGTTAAGAAGGCTGTAGAATCTGCTGATTTGATATTGTCTATCGGTGCTTTGTTGTCTGATTTCAATACCGGTTCTTTCTCTTACTCCTACAAGACCAAAAATATCGTTGAATTCCACTCTGACCACATCAAGATCAGAAACGCCACCTTCCCAGGTGTTCAAATGAAATTTGCCTTGCAAAAATTGTTGGATGCTATTCCAGAAGTCGTCAAGGACTACAAACCTGTTGCTGTCCCAGCTAGAGTTCCAATTACCAAGTCTACTCCAGCTAACACTCCAATGAAGCAAGAATGGATGTGGAACCATTTGGGTAACTTCTTGAGAGAAGGTGATATTGTTATTGCTGAAACCGGTACTTCCGCCTTCGGTATTAACCAAACTACTTTCCCAACAGATGTATACGCTATCGTCCAAGTCTTGTGGGGTTCCATTGGTTTCACAGTCGGCGCTCTATTGGGTGCTACTATGGCCGCTGAAGAACTTGATCCAAAGAAGAGAGTTATTTTATTCATTGGTGACGGTTCTCTACAATTGACTGTTCAAGAAATCTCTACCATGATTAGATGGGGTTTGAAGCCATACATTTTTGTCTTGAATAACAACGGTTACACCATTGAAAAATTGATTCACGGTCCTCATGCCGAATATAATGAAATTCAAGGTTGGGACCACTTGGCCTTATTGCCAACTTTTGGTGCTAGAAACTACGAAACCCACAGAGTTGCTACCACTGGTGAATGGGAAAAGTTGACTCAAGACAAGGACTTCCAAGACAACTCTAAGATTAGAATGATTGAAGTTATGTTGCCAGTCTTTGATGCTCCACAAAACTTGGTTAAACAAGCTCAATTGACTGCCGCTACTAACGCTAAACAATAA","protein_sequence":"MSEITLGKYLFERLSQVNCNTVFGLPGDFNLSLLDKLYEVKGMRWAGNANELNAAYAADGYARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISSQAKQLLLHHTLGNGDFTVFHRMSANISETTAMITDIANAPAEIDRCIRTTYTTQRPVYLGLPANLVDLNVPAKLLETPIDLSLKPNDAEAEAEVVRTVVELIKDAKNPVILADACASRHDVKAETKKLMDLTQFPVYVTPMGKGAIDEQHPRYGGVYVGTLSRPEVKKAVESADLILSIGALLSDFNTGSFSYSYKTKNIVEFHSDHIKIRNATFPGVQMKFALQKLLDAIPEVVKDYKPVAVPARVPITKSTPANTPMKQEWMWNHLGNFLREGDIVIAETGTSAFGINQTTFPTDVYAIVQVLWGSIGFTVGALLGATMAAEELDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYIFVLNNNGYTIEKLIHGPHAEYNEIQGWDHLALLPTFGARNYETHRVATTGEWEKLTQDKDFQDNSKIRMIEVMLPVFDAPQNLVKQAQLTAATNAKQ"},{"created_at":"2011-05-24T20:27:16.000Z","updated_at":"2011-07-22T17:53:52.000Z","name":"Pyruvate decarboxylase isozyme 3","uniprot_id":"P26263","uniprot_name":"PDC6_YEAST","enzyme":true,"transporter":false,"gene_name":"PDC6","num_residues":563,"molecular_weight":"61579.89844","theoretical_pi":"6.11","general_function":"Involved in magnesium ion binding","specific_function":"Minor of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids valine, isoleucine, phenylalanine, and tryptophan, whereas leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins. The expression level of this protein in the presence of fermentable carbon sources is so low that it can not compensate for the other two pyruvate decarboxylases to sustain fermentation","reactions":[{"id":1184,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1186,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1228,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1658,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1841,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1933,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1934,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2319,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm;Nucleus","altext":"A 2-oxo acid = an aldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2320,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2321,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Phenylpyruvate = phenylacetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2322,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Pyruvate = Acetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2323,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"A 2-oxo acid + an aldehyde = A 2-hydroxy ketone + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2324,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"An aldehyde + an aldehyde = A 2-hydroxy ketone.","export":false,"pw_reaction_id":null,"source":null},{"id":14096,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006520","source":"Smpdb"},{"id":14097,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006525","source":"Smpdb"},{"id":14098,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006537","source":"Smpdb"},{"id":14099,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006557","source":"Smpdb"},{"id":14100,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006971","source":"Smpdb"},{"id":14101,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006979","source":"Smpdb"},{"id":14283,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006759","source":"Smpdb"},{"id":14285,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006770","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X55905","genbank_protein_id":"4116","gene_card_id":"PDC6","chromosome_location":"chromosome 7","locus":"YGR087C","synonyms":[],"enzyme_classes":["4.1.1.-","4.1.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" thiamin pyrophosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TPP_enzyme_C","identifier":"PF02775"},{"name":"TPP_enzyme_M","identifier":"PF00205"},{"name":"TPP_enzyme_N","identifier":"PF02776"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Ethanol fermentation","kegg_map_id":null},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Valine Biosynthesis","kegg_map_id":null},{"name":"Valine Degradation","kegg_map_id":null},{"name":"isoleucine biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTCTGAAATTACTCTTGGAAAATACTTATTTGAAAGATTGAAGCAAGTTAATGTTAACACCATTTTTGGGCTACCAGGCGACTTCAACTTGTCCCTATTGGACAAGATTTACGAGGTAGATGGATTGAGATGGGCTGGTAATGCAAATGAGCTGAACGCCGCCTATGCCGCCGATGGTTACGCACGCATCAAGGGTTTATCTGTGCTGGTAACTACTTTTGGCGTAGGTGAATTATCCGCCTTGAATGGTATTGCAGGATCGTATGCAGAACACGTCGGTGTACTGCATGTTGTTGGTGTCCCCTCTATCTCCGCTCAGGCTAAGCAATTGTTGTTGCATCATACCTTGGGTAACGGTGATTTTACCGTTTTTCACAGAATGTCCGCCAATATCTCAGAAACTACATCAATGATTACAGACATTGCTACAGCCCCTTCAGAAATCGATAGGTTGATCAGGACAACATTTATAACACAAAGGCCTAGCTACTTGGGGTTGCCAGCGAATTTGGTAGATCTAAAGGTTCCTGGTTCTCTTTTGGAAAAACCGATTGATCTATCATTAAAACCTAACGATCCCGAAGCTGAAAAGGAAGTTATTGATACCGTACTAGAATTGATCCAGAATTCGAAAAACCCTGTTATACTATCGGATGCCTGTGCTTCTAGGCACAACGTTAAAAAAGAAACCCAGAAGTTAATTGATTTGACGCAATTCCCAGCTTTTGTGACACCTCTAGGTAAAGGGTCAATAGATGAACAGCATCCCAGATATGGCGGTGTTTATGTGGGAACGCTGTCCAAACAAGACGTGAAACAGGCCGTTGAGTCGGCTGATTTGATCCTTTCGGTCGGTGCTTTGCTCTCTGATTTTAACACAGGTTCGTTTTCCTACTCCTACAAGACTAAAAATGTAGTGGAGTTTCATTCCGATTACGTAAAGGTGAAGAACGCTACGTTCCTCGGTGTACAAATGAAATTTGCACTACAAAACTTACTGAAGGTTATTCCCGATGTTGTTAAGGGCTACAAGAGCGTTCCCGTACCAACCAAAACTCCCGCAAACAAAGGTGTACCTGCTAGCACGCCCTTGAAACAAGAGTGGTTGTGGAACGAATTGTCCAAATTCTTGCAAGAAGGTGATGTTATCATTTCCGAGACCGGCACGTCTGCCTTCGGTATCAATCAAACTATCTTTCCTAAGGACGCCTACGGTATCTCGCAGGTGTTGTGGGGGTCCATCGGTTTTACAACAGGAGCAACTTTAGGTGCTGCCTTTGCCGCTGAGGAGATTGACCCCAACAAGAGAGTCATCTTATTCATAGGTGACGGGTCTTTGCAGTTAACCGTCCAAGAAATCTCCACCATGATCAGATGGGGGTTAAAGCCGTATCTTTTTGTCCTTAACAACGACGGCTACACTATCGAAAAGCTGATTCATGGGCCTCACGCAGAGTACAACGAAATCCAGACCTGGGATCACCTCGCCCTGTTGCCCGCATTTGGTGCGAAAAAGTACGAAAATCACAAGATCGCCACTACGGGTGAGTGGGATGCCTTAACCACTGATTCAGAGTTCCAGAAAAACTCGGTGATCAGACTAATTGAACTGAAACTGCCCGTCTTTGATGCTCCGGAAAGTTTGATCAAACAAGCGCAATTGACTGCCGCTACAAATGCCAAACAATAA","protein_sequence":"MSEITLGKYLFERLKQVNVNTIFGLPGDFNLSLLDKIYEVDGLRWAGNANELNAAYAADGYARIKGLSVLVTTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTVFHRMSANISETTSMITDIATAPSEIDRLIRTTFITQRPSYLGLPANLVDLKVPGSLLEKPIDLSLKPNDPEAEKEVIDTVLELIQNSKNPVILSDACASRHNVKKETQKLIDLTQFPAFVTPLGKGSIDEQHPRYGGVYVGTLSKQDVKQAVESADLILSVGALLSDFNTGSFSYSYKTKNVVEFHSDYVKVKNATFLGVQMKFALQNLLKVIPDVVKGYKSVPVPTKTPANKGVPASTPLKQEWLWNELSKFLQEGDVIISETGTSAFGINQTIFPKDAYGISQVLWGSIGFTTGATLGAAFAAEEIDPNKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIHGPHAEYNEIQTWDHLALLPAFGAKKYENHKIATTGEWDALTTDSEFQKNSVIRLIELKLPVFDAPESLIKQAQLTAATNAKQ"},{"created_at":"2011-05-24T20:31:18.000Z","updated_at":"2011-07-22T17:53:52.000Z","name":"Pyruvate decarboxylase isozyme 1","uniprot_id":"P06169","uniprot_name":"PDC1_YEAST","enzyme":true,"transporter":false,"gene_name":"PDC1","num_residues":563,"molecular_weight":"61494.89844","theoretical_pi":"6.11","general_function":"Involved in magnesium ion binding","specific_function":"Major of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-ketoacids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids valine, isoleucine, phenylalanine, and tryptophan, whereas leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins","reactions":[{"id":1184,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1186,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1228,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1658,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1841,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1933,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1934,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2319,"direction":"\u003e","locations":"Cytoplasm. 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Nucleus","genbank_gene_id":"X77316","genbank_protein_id":"871533","gene_card_id":"PDC1","chromosome_location":"chromosome 12","locus":"YLR044C","synonyms":[],"enzyme_classes":["4.1.1.-","4.1.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" thiamin pyrophosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TPP_enzyme_C","identifier":"PF02775"},{"name":"TPP_enzyme_M","identifier":"PF00205"},{"name":"TPP_enzyme_N","identifier":"PF02776"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Ethanol fermentation","kegg_map_id":null},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Valine 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gamma-lyase","uniprot_id":"P31373","uniprot_name":"CYS3_YEAST","enzyme":true,"transporter":false,"gene_name":"CYS3","num_residues":394,"molecular_weight":"42541.69922","theoretical_pi":"6.52","general_function":"Involved in pyridoxal phosphate binding","specific_function":"L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate","reactions":[{"id":1420,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2423,"direction":"\u003e","locations":"Cytoplasm","altext":"L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate.","export":false,"pw_reaction_id":null,"source":null},{"id":3779,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006300","source":"Smpdb"},{"id":3780,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006305","source":"Smpdb"},{"id":14294,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006775","source":"Smpdb"},{"id":14295,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006796","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1N8P","cellular_location":"Cytoplasm","genbank_gene_id":"D14135","genbank_protein_id":"416164","gene_card_id":"CYS3","chromosome_location":"chromosome 1","locus":"YAL012W","synonyms":["Gamma-cystathionase","Sulfur transfer protein 1"],"enzyme_classes":["4.4.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Sulfur 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reductase","uniprot_id":"P41921","uniprot_name":"GSHR_YEAST","enzyme":true,"transporter":false,"gene_name":"GLR1","num_residues":483,"molecular_weight":"53440.60156","theoretical_pi":"7.96","general_function":"Involved in oxidoreductase activity","specific_function":"Maintains high levels of reduced glutathione in the cytosol","reactions":[{"id":2445,"direction":"\u003e","locations":"Cytoplasm","altext":"2 glutathione + NADP(+) = glutathione disulfide + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":3693,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003279","source":"Smpdb"},{"id":3694,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006559","source":"Smpdb"},{"id":3695,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006560","source":"Smpdb"},{"id":3696,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006561","source":"Smpdb"},{"id":3699,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003282","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U43281","genbank_protein_id":"1151235","gene_card_id":"GLR1","chromosome_location":"chromosome 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NH(3).","export":false,"pw_reaction_id":null,"source":null},{"id":3864,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006385","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"M85194","genbank_protein_id":"172589","gene_card_id":"CHA1","chromosome_location":"chromosome 3","locus":"YCL064C","synonyms":["L-serine dehydratase","L-serine deaminase","L-threonine dehydratase","L-threonine deaminase"],"enzyme_classes":["4.3.1.17","4.3.1.19"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"PALP","identifier":"PF00291"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"serine 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phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"PALP","identifier":"PF00291"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine and methionine 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+ NH(3) + pyruvate","reactions":[{"id":1418,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2518,"direction":"\u003e","locations":"Cytoplasm. 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Does not act on isocitrate","reactions":[{"id":1735,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2527,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"Z48951","genbank_protein_id":"763005","gene_card_id":"ICL2","chromosome_location":"chromosome 16","locus":"YPR006C","synonyms":["Methylisocitrate lyase"],"enzyme_classes":["4.1.3.30"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" isocitrate lyase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" lyase 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carboxylase 1","uniprot_id":"P11154","uniprot_name":"PYC1_YEAST","enzyme":true,"transporter":false,"gene_name":"PYC1","num_residues":1178,"molecular_weight":"130098.0","theoretical_pi":"6.15","general_function":"Involved in catalytic activity","specific_function":"Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second","reactions":[{"id":1932,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2594,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + pyruvate + HCO(3)(-) = ADP + phosphate + oxaloacetate.","export":false,"pw_reaction_id":null,"source":null},{"id":14121,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006553","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"J03889","genbank_protein_id":"172102","gene_card_id":"PYC1","chromosome_location":"chromosome 7","locus":"YGL062W","synonyms":["Pyruvic carboxylase 1","PCB 1"],"enzyme_classes":["6.4.1.1"],"go_classes":[{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" biotin binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-carbon bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" pyruvate carboxylase activity"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" gluconeogenesis"}],"pfams":[{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"Biotin_carb_C","identifier":"PF02785"},{"name":"Biotin_lipoyl","identifier":"PF00364"},{"name":"HMGL-like","identifier":"PF00682"},{"name":"PYC_OADA","identifier":"PF02436"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Pyruvate 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carboxy-biotin-[carboxyl-carrier-protein].","export":false,"pw_reaction_id":null,"source":null},{"id":3705,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003286","source":"Smpdb"},{"id":3706,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006568","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1OD4","cellular_location":"Cytoplasm","genbank_gene_id":"Z71631","genbank_protein_id":"1302498","gene_card_id":"FAS3","chromosome_location":null,"locus":"YNR016C","synonyms":["ACC","Biotin carboxylase"],"enzyme_classes":["6.4.1.2","6.3.4.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" biotin binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-carbon bonds"},{"category":"Function","description":" CoA carboxylase activity"},{"category":"Function","description":" acetyl-CoA carboxylase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fatty acid biosynthetic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"Biotin_carb_C","identifier":"PF02785"},{"name":"Biotin_lipoyl","identifier":"PF00364"},{"name":"ACC_central","identifier":"PF08326"},{"name":"Carboxyl_trans","identifier":"PF01039"}],"pathways":[{"name":"Fatty acid biosynthesis","kegg_map_id":"00061"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGAGCGAAGAAAGCTTATTCGAGTCTTCTCCACAGAAGATGGAGTACGAAATTACAAACTACTCAGAAAGACATACAGAACTTCCAGGTCATTTCATTGGCCTCAATACAGTAGATAAACTAGAGGAGTCCCCGTTAAGGGACTTTGTTAAGAGTCACGGTGGTCACACGGTCATATCCAAGATCCTGATAGCAAATAATGGTATTGCCGCCGTGAAAGAAATTAGATCCGTCAGAAAATGGGCATACGAGACGTTCGGCGATGACAGAACCGTCCAATTCGTCGCCATGGCCACCCCAGAAGATCTGGAGGCCAACGCAGAATATATCCGTATGGCCGATCAATACATTGAAGTGCCAGGTGGTACTAATAATAACAACTACGCTAACGTAGACTTGATCGTAGACATCGCCGAAAGAGCAGACGTAGACGCCGTATGGGCTGGCTGGGGTCACGCCTCCGAGAATCCACTATTGCCTGAAAAATTGTCCCAGTCTAAGAGGAAAGTCATCTTTATTGGGCCTCCAGGTAACGCCATGAGGTCTTTAGGTGATAAAATCTCCTCTACCATTGTCGCTCAAAGTGCTAAAGTCCCATGTATTCCATGGTCTGGTACCGGTGTTGACACCGTTCACGTGGACGAGAAAACCGGTCTGGTCTCTGTCGACGATGACATCTATCAAAAGGGTTGTTGTACCTCTCCTGAAGATGGTTTACAAAAGGCCAAGCGTATTGGTTTTCCTGTCATGATTAAGGCATCCGAAGGTGGTGGTGGTAAAGGTATCAGACAAGTTGAACGTGAAGAAGATTTCATCGCTTTATACCACCAGGCAGCCAACGAAATTCCAGGCTCCCCCATTTTCATCATGAAGTTGGCCGGTAGAGCGCGTCACTTGGAAGTTCAACTGCTAGCAGATCAGTACGGTACAAATATTTCCTTGTTCGGTAGAGACTGTTCCGTTCAGAGACGTCATCAAAAAATTATCGAAGAAGCACCAGTTACAATTGCCAAGGCTGAAACATTTCACGAGATGGAAAAGGCTGCCGTCAGACTGGGGAAACTAGTCGGTTATGTCTCTGCCGGTACCGTGGAGTATCTATATTCTCATGATGATGGAAAATTCTACTTTTTAGAATTGAACCCAAGATTACAAGTCGAGCATCCAACAACGGAAATGGTCTCCGGTGTTAACTTACCTGCAGCTCAATTACAAATCGCTATGGGTATCCCTATGCATAGAATAAGTGACATTAGAACTTTATATGGTATGAATCCTCATTCTGCCTCAGAAATCGATTTCGAATTCAAAACTCAAGATGCCACCAAGAAACAAAGAAGACCTATTCCAAAGGGTCATTGTACCGCTTGTCGTATCACATCAGAAGATCCAAACGATGGATTCAAGCCATCGGGTGGTACTTTGCATGAACTAAACTTCCGTTCTTCCTCTAATGTTTGGGGTTACTTCTCCGTGGGTAACAATGGTAATATTCACTCCTTTTCGGACTCTCAGTTCGGCCATATTTTTGCTTTTGGTGAAAATAGACAAGCTTCCAGGAAACACATGGTTGTTGCCCTGAAGGAATTGTCCATTAGGGGTGATTTCAGAACTACTGTGGAATACTTGATCAAACTTTTGGAAACTGAAGATTTCGAGGATAACACTATTACCACCGGTTGGTTGGACGATTTGATTACTCATAAAATGACCGCTGAAAAGCCTGATCCAACTCTTGCCGTCATTTGCGGTGCCGCTACAAAGGCTTTCTTAGCATCTGAAGAAGCCCGCCACAAGTATATCGAATCCTTACAAAAGGGACAAGTTCTATCTAAAGACCTACTGCAAACTATGTTCCCTGTAGATTTTATCCATGAGGGTAAAAGATACAAGTTCACCGTAGCTAAATCCGGTAATGACCGTTACACATTATTTATCAATGGTTCTAAATGTGATATCATACTGCGTCAACTATCTGATGGTGGTCTTTTGATTGCCATAGGCGGTAAATCGCATACCATCTATTGGAAAGAAGAAGTTGCTGCTACAAGATTATCCGTTGACTCTATGACTACTTTGTTGGAAGTTGAAAACGATCCAACCCAGTTGCGTACTCCATCCCCTGGTAAATTGGTTAAATTCTTGGTGGAAAATGGTGAACACATTATCAAGGGCCAACCATATGCAGAAATTGAAGTTATGAAAATGCAAATGCCTTTGGTTTCTCAAGAAAATGGTATCGTCCAGTTATTAAAGCAACCTGGTTCTACCATTGTTGCAGGTGATATCATGGCTATTATGACTCTTGACGATCCATCCAAGGTCAAGCACGCTCTACCATTTGAAGGTATGCTGCCAGATTTTGGTTCTCCAGTTATCGAAGGAACCAAACCTGCCTATAAATTCAAGTCATTAGTGTCTACTTTGGAAAACATTTTGAAGGGTTATGACAACCAAGTTATTATGAACGCTTCCTTGCAACAATTGATAGAGGTTTTGAGAAATCCAAAACTGCCTTACTCAGAATGGAAACTACACATCTCTGCTTTACATTCAAGATTGCCTGCTAAGCTAGATGAACAAATGGAAGAGTTAGTTGCACGTTCTTTGAGACGTGGTGCTGTTTTCCCAGCTAGACAATTAAGTAAATTGATTGATATGGCCGTGAAGAATCCTGAATACAACCCCGACAAATTGCTGGGCGCCGTCGTGGAACCATTGGCGGATATTGCTCATAAGTACTCTAACGGGTTAGAAGCCCATGAACATTCTATATTTGTCCATTTCTTGGAAGAATATTACGAAGTTGAAAAGTTATTCAATGGTCCAAATGTTCGTGAGGAAAATATCATTCTGAAATTGCGTGATGAAAACCCTAAAGATCTAGATAAAGTTGCGCTAACTGTTTTGTCTCATTCGAAAGTTTCAGCGAAGAATAACCTGATCCTAGCTATCTTGAAACATTATCAACCATTGTGCAAGTTATCTTCTAAAGTTTCTGCCATTTTCTCTACTCCTCTACAACATATTGTTGAACTAGAATCTAAGGCTACCGCTAAGGTCGCTCTACAAGCAAGAGAAATTTTGATTCAAGGCGCTTTACCTTCGGTCAAGGAAAGAACTGAACAAATTGAACATATCTTAAAATCCTCTGTTGTGAAGGTTGCCTATGGCTCATCCAATCCAAAGCGCTCTGAACCAGATTTGAATATCTTGAAGGACTTGATCGATTCTAATTACGTTGTGTTCGATGTTTTACTTCAATTCCTAACCCATCAAGACCCAGTTGTGACTGCTGCAGCTGCTCAAGTCTATATTCGTCGTGCTTATCGTGCTTACACCATAGGAGATATTAGAGTTCACGAAGGTGTCACAGTTCCAATTGTTGAATGGAAATTCCAACTACCTTCAGCTGCGTTCTCCACCTTTCCAACTGTTAAATCTAAAATGGGTATGAACAGGGCTGTTTCTGTTTCAGATTTGTCATATGTTGCAAACAGTCAGTCATCTCCGTTAAGAGAAGGTATTTTGATGGCTGTGGATCATTTAGATGATGTTGATGAAATTTTGTCACAAAGTTTGGAAGTTATTCCTCGTCACCAATCTTCTTCTAACGGACCTGCTCCTGATCGTTCTGGTAGCTCCGCATCGTTGAGTAATGTTGCTAATGTTTGTGTTGCTTCTACAGAAGGTTTCGAATCTGAAGAGGAAATTTTGGTAAGGTTGAGAGAAATTTTGGATTTGAATAAGCAGGAATTAATCAATGCTTCTATCCGTCGTATCACATTTATGTTCGGTTTTAAAGATGGGTCTTATCCAAAGTATTATACTTTTAACGGTCCAAATTATAACGAAAATGAAACAATTCGTCACATTGAGCCGGCTTTGGCCTTCCAACTGGAATTAGGAAGATTGTCCAACTTCAACATTAAACCAATTTTCACTGATAATAGAAACATCCATGTCTACGAAGCTGTTAGTAAGACTTCTCCATTGGATAAGAGATTCTTTACAAGAGGTATTATTAGAACGGGTCATATCCGTGATGACATTTCTATTCAAGAATATCTGACTTCTGAAGCTAACAGATTGATGAGTGATATATTGGATAATTTAGAAGTCACCGACACTTCAAATTCTGATTTGAATCATATCTTCATCAACTTCATTGCGGTGTTTGATATCTCTCCAGAAGATGTCGAAGCCGCCTTCGGTGGTTTCTTAGAAAGATTTGGTAAGAGATTGTTGAGATTGCGTGTTTCTTCTGCCGAAATTAGAATCATCATCAAAGATCCTCAAACAGGTGCCCCAGTACCATTGCGTGCCTTGATCAATAACGTTTCTGGTTATGTTATCAAAACAGAAATGTACACCGAAGTCAAGAACGCAAAAGGTGAATGGGTATTTAAGTCTTTGGGTAAACCTGGATCCATGCATTTAAGACCTATTGCTACTCCTTACCCTGTTAAGGAATGGTTGCAACCAAAACGTTATAAGGCACACTTGATGGGTACCACATATGTCTATGACTTCCCAGAATTATTCCGCCAAGCATCGTCATCCCAATGGAAAAATTTCTCTGCAGATGTTAAGTTAACAGATGATTTCTTTATTTCCAACGAGTTGATTGAAGATGAAAACGGCGAATTAACTGAGGTGGAAAGAGAACCTGGTGCCAACGCTATTGGTATGGTTGCCTTTAAGATTACTGTAAAGACTCCTGAATATCCAAGAGGCCGTCAATTTGTTGTTGTTGCTAACGATATCACATTCAAGATCGGTTCCTTTGGTCCACAAGAAGACGAATTCTTCAATAAGGTTACTGAATATGCTAGAAAGCGTGGTATCCCAAGAATTTACTTGGCTGCAAACTCAGGTGCCAGAATTGGTATGGCTGAAGAGATTGTTCCACTATTTCAAGTTGCATGGAATGATGCTGCCAATCCGGACAAGGGCTTCCAATACTTATACTTAACAAGTGAAGGTATGGAAACTTTAAAGAAATTTGACAAAGAAAATTCTGTTCTCACTGAACGTACTGTTATAAACGGTGAAGAAAGATTTGTCATCAAGACAATTATTGGTTCTGAAGATGGGTTAGGTGTCGAATGTCTACGTGGATCTGGTTTAATTGCTGGTGCAACGTCAAGGGCTTACCACGATATCTTCACTATCACCTTAGTCACTTGTAGATCCGTCGGTATCGGTGCTTATTTGGTTCGTTTGGGTCAAAGAGCTATTCAGGTCGAAGGCCAGCCAATTATTTTAACTGGTGCTCCTGCAATCAACAAAATGCTGGGTAGAGAAGTTTATACTTCTAACTTACAATTGGGTGGTACTCAAATCATGTATAACAACGGTGTTTCACATTTGACTGCTGTTGACGATTTAGCTGGTGTAGAGAAGATTGTTGAATGGATGTCTTATGTTCCAGCCAAGCGTAATATGCCAGTTCCTATCTTGGAAACTAAAGACACATGGGATAGACCAGTTGATTTCACTCCAACTAATGATGAAACTTACGATGTAAGATGGATGATTGAAGGTCGTGAGACTGAAAGTGGATTTGAATATGGTTTGTTTGATAAAGGGTCTTTCTTTGAAACTTTGTCAGGATGGGCCAAAGGTGTTGTCGTTGGTAGAGCCCGTCTTGGTGGTATTCCACTGGGTGTTATTGGTGTTGAAACAAGAACTGTCGAGAACTTGATTCCTGCTGATCCAGCTAATCCAAATAGTGCTGAAACATTAATTCAAGAACCTGGTCAAGTTTGGCATCCAAACTCCGCCTTCAAGACTGCTCAAGCTATCAATGACTTTAACAACGGTGAACAATTGCCAATGATGATTTTGGCCAACTGGAGAGGTTTCTCTGGTGGTCAACGTGATATGTTCAACGAAGTCTTGAAGTATGGTTCGTTTATTGTTGACGCATTGGTGGATTACAAACAACCAATTATTATCTATATCCCACCTACCGGTGAACTAAGAGGTGGTTCATGGGTTGTTGTCGATCCAACTATCAACGCTGACCAAATGGAAATGTATGCCGACGTCAACGCTAGAGCTGGTGTTTTGGAACCACAAGGTATGGTTGGTATCAAGTTCCGTAGAGAAAAATTGCTGGACACCATGAACAGATTGGATGACAAGTACAGAGAATTGAGATCTCAATTATCCAACAAGAGTTTGGCTCCAGAAGTACATCAGCAAATATCCAAGCAATTAGCTGATCGTGAGAGAGAACTATTGCCAATTTACGGACAAATCAGTCTTCAATTTGCTGATTTGCACGATAGGTCTTCACGTATGGTGGCCAAGGGTGTTATTTCTAAGGAACTGGAATGGACCGAGGCACGTCGTTTCTTCTTCTGGAGATTGAGAAGAAGATTGAACGAAGAATATTTGATTAAAAGGTTGAGCCATCAGGTAGGCGAAGCATCAAGATTAGAAAAGATCGCAAGAATTAGATCGTGGTACCCTGCTTCAGTGGACCATGAAGATGATAGGCAAGTCGCAACATGGATTGAAGAAAACTACAAAACTTTGGACGATAAACTAAAGGGTTTGAAATTAGAGTCATTCGCTCAAGACTTAGCTAAAAAGATCAGAAGCGACCATGACAATGCTATTGATGGATTATCTGAAGTTATCAAGATGTTATCTACCGATGATAAAGAAAAATTGTTGAAGACTTTGAAATAA","protein_sequence":"MSEESLFESSPQKMEYEITNYSERHTELPGHFIGLNTVDKLEESPLRDFVKSHGGHTVISKILIANNGIAAVKEIRSVRKWAYETFGDDRTVQFVAMATPEDLEANAEYIRMADQYIEVPGGTNNNNYANVDLIVDIAERADVDAVWAGWGHASENPLLPEKLSQSKRKVIFIGPPGNAMRSLGDKISSTIVAQSAKVPCIPWSGTGVDTVHVDEKTGLVSVDDDIYQKGCCTSPEDGLQKAKRIGFPVMIKASEGGGGKGIRQVEREEDFIALYHQAANEIPGSPIFIMKLAGRARHLEVQLLADQYGTNISLFGRDCSVQRRHQKIIEEAPVTIAKAETFHEMEKAAVRLGKLVGYVSAGTVEYLYSHDDGKFYFLELNPRLQVEHPTTEMVSGVNLPAAQLQIAMGIPMHRISDIRTLYGMNPHSASEIDFEFKTQDATKKQRRPIPKGHCTACRITSEDPNDGFKPSGGTLHELNFRSSSNVWGYFSVGNNGNIHSFSDSQFGHIFAFGENRQASRKHMVVALKELSIRGDFRTTVEYLIKLLETEDFEDNTITTGWLDDLITHKMTAEKPDPTLAVICGAATKAFLASEEARHKYIESLQKGQVLSKDLLQTMFPVDFIHEGKRYKFTVAKSGNDRYTLFINGSKCDIILRQLSDGGLLIAIGGKSHTIYWKEEVAATRLSVDSMTTLLEVENDPTQLRTPSPGKLVKFLVENGEHIIKGQPYAEIEVMKMQMPLVSQENGIVQLLKQPGSTIVAGDIMAIMTLDDPSKVKHALPFEGMLPDFGSPVIEGTKPAYKFKSLVSTLENILKGYDNQVIMNASLQQLIEVLRNPKLPYSEWKLHISALHSRLPAKLDEQMEELVARSLRRGAVFPARQLSKLIDMAVKNPEYNPDKLLGAVVEPLADIAHKYSNGLEAHEHSIFVHFLEEYYEVEKLFNGPNVREENIILKLRDENPKDLDKVALTVLSHSKVSAKNNLILAILKHYQPLCKLSSKVSAIFSTPLQHIVELESKATAKVALQAREILIQGALPSVKERTEQIEHILKSSVVKVAYGSSNPKRSEPDLNILKDLIDSNYVVFDVLLQFLTHQDPVVTAAAAQVYIRRAYRAYTIGDIRVHEGVTVPIVEWKFQLPSAAFSTFPTVKSKMGMNRAVSVSDLSYVANSQSSPLREGILMAVDHLDDVDEILSQSLEVIPRHQSSSNGPAPDRSGSSASLSNVANVCVASTEGFESEEEILVRLREILDLNKQELINASIRRITFMFGFKDGSYPKYYTFNGPNYNENETIRHIEPALAFQLELGRLSNFNIKPIFTDNRNIHVYEAVSKTSPLDKRFFTRGIIRTGHIRDDISIQEYLTSEANRLMSDILDNLEVTDTSNSDLNHIFINFIAVFDISPEDVEAAFGGFLERFGKRLLRLRVSSAEIRIIIKDPQTGAPVPLRALINNVSGYVIKTEMYTEVKNAKGEWVFKSLGKPGSMHLRPIATPYPVKEWLQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADVKLTDDFFISNELIEDENGELTEVEREPGANAIGMVAFKITVKTPEYPRGRQFVVVANDITFKIGSFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARIGMAEEIVPLFQVAWNDAANPDKGFQYLYLTSEGMETLKKFDKENSVLTERTVINGEERFVIKTIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVTCRSVGIGAYLVRLGQRAIQVEGQPIILTGAPAINKMLGREVYTSNLQLGGTQIMYNNGVSHLTAVDDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDRPVDFTPTNDETYDVRWMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVVGRARLGGIPLGVIGVETRTVENLIPADPANPNSAETLIQEPGQVWHPNSAFKTAQAINDFNNGEQLPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVDYKQPIIIYIPPTGELRGGSWVVVDPTINADQMEMYADVNARAGVLEPQGMVGIKFRREKLLDTMNRLDDKYRELRSQLSNKSLAPEVHQQISKQLADRERELLPIYGQISLQFADLHDRSSRMVAKGVISKELEWTEARRFFFWRLRRRLNEEYLIKRLSHQVGEASRLEKIARIRSWYPASVDHEDDRQVATWIEENYKTLDDKLKGLKLESFAQDLAKKIRSDHDNAIDGLSEVIKMLSTDDKEKLLKTLK"},{"created_at":"2011-05-26T21:25:22.000Z","updated_at":"2011-05-26T21:25:22.000Z","name":"Pyruvate 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phosphoenolpyruvate.","export":false,"pw_reaction_id":null,"source":null},{"id":3818,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006332","source":"Smpdb"},{"id":14120,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006551","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1A3X","cellular_location":null,"genbank_gene_id":"AY693107","genbank_protein_id":"51013665","gene_card_id":"PYK1","chromosome_location":null,"locus":"YAL038W","synonyms":["PK 1"],"enzyme_classes":["2.7.1.40"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" alkali metal ion binding"},{"category":"Function","description":" potassium ion binding"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" pyruvate kinase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PK","identifier":"PF00224"},{"name":"PK_C","identifier":"PF02887"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Glycolysis I","kegg_map_id":null}],"gene_sequence":"ATGTCTAGATTAGAAAGATTGACCTCATTAAACGTTGTTGCTGGTTCTGACTTGAGAAGAACCTCCATCATTGGTACCATCGGTCCAAAGACCAACAACCCAGAAACCTTGGTTGCTTTGAGAAAGGCTGGTTTGAACATTGTCCGTATGAACTTCTCTCACGGTTCTTACGAATACCACAAGTCTGTCATTGACAACGCCAGAAAGTCCGAAGAATTGTACCCAGGTAGGCCATTGGCCATTGCTTTGGACACCAAGGGTCCAGAAATCAGAACTGGTACCACCACCAACGATGTTGACTACCCAATCCCACCAAACCACGAAATGATCTTCACCACCGATGACAAGTACGCTAAGGCTTGTGACGACAAGATCATGTACGTTGACTACAAGAACATCACCAAGGTCATCTCCGCTGGTAGAATCATCTACGTTGATGATGGTGTTTTGTCTTTCCAAGTTTTGGAAGTCGTTGACGACAAGACTTTGAAGGTCAAGGCTTTGAACGCCGGTAAGATCTGTTCCCACAAGGGTGTCAACTTACCAGGTACCGATGTCGATTTGCCAGCTTTGTCTGAAAAGGACAAGGAAGATTTGAGATTCGGTGTCAAGAACGGTGTCCACATGGTCTTCGCTTCTTTCATCAGAACCGCCAACGATGTTTTGACCATCAGAGAAGTCTTGGGTGAACAAGGTAAGGACGTCAAGATCATTGTCAAGATTGAAAACCAACAAGGTGTTAACAACTTCGACGAAATCTTGAAGGTCACTGACGGTGTTATGGTTGCCAGAGGTGACTTGGGTATTGAAATCCCAGCCCCAGAAGTCTTGGCTGTCCAAAAGAAATTGATTGCTAAGTCTAACTTGGCTGGTAAGCCAGTTATCTGTGCTACCCAAATGTTGGAATCCATGACTTACAACCCAAGACCAACCAGAGCTGAAGTTTCCGATGTCGGTAACGCTATCTTGGATGGTGCTGACTGTGTTATGTTGTCTGGTGAAACCGCCAAGGGTAACTACCCAATCAACGCCGTTACCACTATGGCTGAAACCGCTGTCATTGCTGAACAAGCTATCGCTTACTTGCCAAACTACGATGACATGAGAAACTGTACTCCAAAGCCAACCTCCACCACCGAAACCGTCGCTGCCTCCGCTGTCGCTGCTGTTTTCGAACAAAAGGCCAAGGCTATCATTGTCTTGTCCACTTCCGGTACCACCCCAAGATTGGTTTCCAAGTACAGACCAAACTGTCCAATCATCTTGGTTACCAGATGCCCAAGAGCTGCTAGATTCTCTCACTTGTACAGAGGTGTCTTCCCATTCGTTTTCGAAAAGGAACCTGTCTCTGACTGGACTGATGATGTTGAAGCCCGTATCAACTTCGGTATTGAAAAGGCTAAGGAATTCGGTATCTTGAAGAAGGGTGACACTTACGTTTCCATCCAAGGTTTCAAGGCCGGTGCTGGTCACTCCAACACTTTGCAAGTCTCTACCGTTTAA","protein_sequence":"MSRLERLTSLNVVAGSDLRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKSEELYPGRPLAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKEDLRFGVKNGVHMVFASFIRTANDVLTIREVLGEQGKDVKIIVKIENQQGVNNFDEILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNYDDMRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFSHLYRGVFPFVFEKEPVSDWTDDVEARINFGIEKAKEFGILKKGDTYVSIQGFKAGAGHSNTLQVSTV"},{"created_at":"2011-05-26T21:27:15.000Z","updated_at":"2011-05-27T15:01:11.000Z","name":"Pyruvate kinase 2","uniprot_id":"P52489","uniprot_name":"KPYK2_YEAST","enzyme":true,"transporter":false,"gene_name":"PYK2","num_residues":506,"molecular_weight":"55194.69922","theoretical_pi":"6.91","general_function":"Involved in magnesium ion binding","specific_function":"May be used by cells under conditions in which the level of glycolytic flux is very low","reactions":[{"id":1936,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2609,"direction":"\u003e","locations":"","altext":"ATP + pyruvate = ADP + phosphoenolpyruvate.","export":false,"pw_reaction_id":null,"source":null},{"id":14120,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006551","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X95720","genbank_protein_id":"1199849","gene_card_id":"PYK2","chromosome_location":"chromosome 15","locus":"YOR347C","synonyms":["PK 2"],"enzyme_classes":["2.7.1.40"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" alkali metal ion binding"},{"category":"Function","description":" potassium ion binding"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" pyruvate kinase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PK","identifier":"PF00224"},{"name":"PK_C","identifier":"PF02887"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Ethanol fermentation","kegg_map_id":null}],"gene_sequence":"ATGCCAGAGTCCAGATTGCAGAGACTAGCTAATTTGAAAATAGGAACTCCGCAGCAGCTCAGACGCACCTCCATAATAGGTACCATTGGGCCCAAGACAAATAGCTGCGAGGCCATTACTGCTCTGAGAAAAGCTGGTTTGAACATCATTCGATTGAACTTTTCCCATGGCTCCTACGAATTCCATCAATCAGTAATCGAAAATGCTGTGAAATCGGAACAGCAATTCCCTGGCAGGCCGCTCGCCATTGCCCTGGATACCAAGGGTCCCGAGATCAGAACAGGTCGCACGTTAAATGACCAAGATCTTTATATCCCCGTAGACCACCAAATGATCTTTACCACTGACGCAAGTTTTGCAAACACCTCCAATGATAAAATCATGTATATAGACTATGCTAACCTGACAAAAGTTATCGTTCCGGGGAGATTTATATACGTGGACGACGGGATTCTCTCTTTTAAAGTGCTCCAAATCATTGACGAATCTAATTTAAGGGTGCAAGCGGTAAACTCGGGTTATATCGCATCTCATAAAGGTGTTAATCTGCCTAATACCGACGTTGATTTGCCCCCCTTGTCCGCCAAAGACATGAAGGACTTGCAATTCGGAGTCCGCAATGGCATTCACATCGTATTTGCCTCTTTCATAAGAACTTCAGAAGATGTGTTGTCTATCAGAAAAGCGTTGGGTTCTGAAGGGCAAGATATCAAGATTATATCCAAGATAGAAAACCAGCAAGGGTTGGATAATTTTGACGAAATCCTGGAAGTCACGGATGGTGTTATGATAGCGAGAGGCGATTTAGGAATTGAAATCCTGGCACCTGAAGTATTAGCCATTCAAAAAAAGCTGATTGCAAAATGTAATTTGGCGGGCAAACCTGTCATTTGCGCGACTCAGATGCTGGATTCAATGACACACAATCCGAGACCGACAAGGGCTGAAGTATCGGATGTGGGTAACGCTGTGTTGGATGGTGCTGATTGTGTTATGCTTTCTGGAGAAACGGCGAAGGGTGATTATCCGGTGAATGCAGTTAATATTATGGCGGCGACCGCTCTGATTGCTGAAAGTACTATCGCTCATTTGGCTCTTTATGACGATCTCAGAGACGCCACTCCCAAACCTACTTCCACTACGGAAACTGTAGCAGCTGCAGCTACCGCAGCAATCTTGGAGCAAGATGGTAAGGCCATCGTTGTATTATCTACTACAGGGAACACGGCAAGGCTACTGTCGAAGTATAGACCAAGCTGCCCTATCATATTAGTAACAAGACACGCAAGAACGGCAAGAATTGCGCATTTGTATAGAGGTGTTTTCCCATTTCTGTATGAACCGAAACGCCTAGACGACTGGGGTGAGGATGTTCATAGGCGCCTAAAGTTTGGTGTTGAAATGGCGAGGTCTTTCGGAATGGTGGACAACGGTGATACTGTTGTTTCCATTCAAGGATTCAAAGGAGGAGTCGGCCATTCCAATACCTTACGCATTTCTACTGTTGGTCAAGAATTCTAG","protein_sequence":"MPESRLQRLANLKIGTPQQLRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFPGRPLAIALDTKGPEIRTGRTLNDQDLYIPVDHQMIFTTDASFANTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYIASHKGVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPSCPIILVTRHARTARIAHLYRGVFPFLYEPKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQGFKGGVGHSNTLRISTVGQEF"},{"created_at":"2011-05-27T01:11:54.000Z","updated_at":"2011-05-27T15:01:14.000Z","name":"Pyruvate carboxylase 2","uniprot_id":"P32327","uniprot_name":"PYC2_YEAST","enzyme":true,"transporter":false,"gene_name":"PYC2","num_residues":1180,"molecular_weight":"130166.0","theoretical_pi":"6.47","general_function":"Involved in catalytic activity","specific_function":"Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second","reactions":[{"id":1932,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2594,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + pyruvate + HCO(3)(-) = ADP + phosphate + oxaloacetate.","export":false,"pw_reaction_id":null,"source":null},{"id":14121,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006553","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U35647","genbank_protein_id":"1041735","gene_card_id":"PYC2","chromosome_location":"chromosome 2","locus":"YBR218C","synonyms":["Pyruvic carboxylase 2","PCB 2"],"enzyme_classes":["6.4.1.1"],"go_classes":[{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" biotin binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-carbon bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" pyruvate carboxylase activity"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" gluconeogenesis"}],"pfams":[{"name":"CPSase_L_chain","identifier":"PF00289"},{"name":"CPSase_L_D2","identifier":"PF02786"},{"name":"Biotin_carb_C","identifier":"PF02785"},{"name":"Biotin_lipoyl","identifier":"PF00364"},{"name":"HMGL-like","identifier":"PF00682"},{"name":"PYC_OADA","identifier":"PF02436"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Pyruvate 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NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":14123,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006555","source":"Smpdb"},{"id":14124,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006556","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"Z28029","genbank_protein_id":"486030","gene_card_id":"MAE1","chromosome_location":"chromosome 11","locus":"YKL029C","synonyms":["NAD-ME"],"enzyme_classes":["1.1.1.38"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" malate dehydrogenase activity"},{"category":"Function","description":" malic enzyme activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" dicarboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" malate metabolic 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Available"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Tryptophan 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dehydrogenase E1 component subunit alpha, mitochondrial","uniprot_id":"P16387","uniprot_name":"ODPA_YEAST","enzyme":true,"transporter":false,"gene_name":"PDA1","num_residues":420,"molecular_weight":"46342.69922","theoretical_pi":"8.24","general_function":"Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor","specific_function":"The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)","reactions":[{"id":2710,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"M29582","genbank_protein_id":"172108","gene_card_id":"PDA1","chromosome_location":"chromosome 5","locus":"YER178W","synonyms":["Pyruvate dehydrogenase complex component E1 alpha","PDHE1-A"],"enzyme_classes":["1.2.4.1"],"go_classes":[{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"},{"category":"Function","description":" pyruvate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" pyruvate dehydrogenase (acetyl-transferring) activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"}],"pfams":[{"name":"E1_dh","identifier":"PF00676"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Butanoate 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b2, mitochondrial","uniprot_id":"P00175","uniprot_name":"CYB2_YEAST","enzyme":true,"transporter":false,"gene_name":"CYB2","num_residues":591,"molecular_weight":"65538.79688","theoretical_pi":"8.62","general_function":"Involved in catalytic activity","specific_function":"(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+)","reactions":[{"id":2711,"direction":"\u003e","locations":"Mitochondrion intermembrane space","altext":"(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1KBI","cellular_location":"Mitochondrion intermembrane space","genbank_gene_id":"X03215","genbank_protein_id":"3633","gene_card_id":"CYB2","chromosome_location":"chromosome 13","locus":"YML054C","synonyms":["L-lactate dehydrogenase [Cytochrome]","L-lactate ferricytochrome C 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process"}],"pfams":[{"name":"Cyt-b5","identifier":"PF00173"},{"name":"FMN_dh","identifier":"PF01070"}],"pathways":[{"name":"Pyruvate 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4","locus":"YDL174C","synonyms":["D-lactate ferricytochrome C oxidoreductase","D-LCR"],"enzyme_classes":["1.1.2.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"FAD_binding_4","identifier":"PF01565"},{"name":"FAD-oxidase_C","identifier":"PF02913"}],"pathways":[{"name":"Pyruvate 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dehydrogenase E1 component subunit beta, mitochondrial","uniprot_id":"P32473","uniprot_name":"ODPB_YEAST","enzyme":true,"transporter":false,"gene_name":"PDB1","num_residues":366,"molecular_weight":"40053.19922","theoretical_pi":"4.95","general_function":"Involved in catalytic activity","specific_function":"The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)","reactions":[{"id":2710,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3693,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003279","source":"Smpdb"},{"id":3694,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006559","source":"Smpdb"},{"id":3695,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006560","source":"Smpdb"},{"id":3696,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006561","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY692982","genbank_protein_id":"51013415","gene_card_id":"PDB1","chromosome_location":"chromosome 2","locus":"YBR221C","synonyms":["Pyruvate dehydrogenase complex component E1 beta","PDHE1-B"],"enzyme_classes":["1.2.4.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Transket_pyr","identifier":"PF02779"},{"name":"Transketolase_C","identifier":"PF02780"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTTTTCCAGACTGCCAACATCATTGGCCAGAAATGTTGCACGTCGTGCCCCAACTTCTTTTGTAAGACCCTCTGCAGCAGCAGCAGCATTGAGATTCTCATCAACAAAGACGATGACCGTCAGAGAGGCCTTGAATAGTGCCATGGCGGAAGAATTGGACCGTGATGATGATGTCTTCCTTATTGGTGAAGAAGTTGCACAATATAACGGGGCTTATAAGGTGTCAAAGGGTTTATTGGACAGGTTCGGTGAACGTCGTGTGGTTGACACACCTATTACCGAATACGGGTTCACAGGTTTGGCCGTTGGTGCCGCTTTGAAGGGTTTGAAGCCAATTGTAGAGTTTATGTCGTTCAATTTCTCTATGCAAGCTATCGATCATGTTGTCAATTCCGCTGCAAAGACTCACTACATGTCTGGTGGTACTCAAAAATGTCAAATGGTCTTCAGAGGTCCTAATGGTGCTGCAGTGGGTGTTGGTGCTCAACATTCACAGGACTTTTCTCCTTGGTACGGTTCCATTCCAGGGTTAAAGGTCCTTGTCCCTTATTCTGCTGAAGATGCTAGGGGTTTGTTAAAGGCCGCCATCAGAGATCCAAACCCTGTTGTATTTTTAGAGAACGAATTGTTGTACGGTGAATCTTTTGAAATCTCAGAAGAAGCTTTATCCCCTGAGTTCACCTTGCCATACAAGGCTAAGATCGAAAGAGAAGGTACCGATATTTCCATTGTTACGTACACAAGAAACGTTCAGTTTTCTTTGGAAGCCGCTGAAATTCTACAAAAGAAATATGGTGTCTCTGCAGAAGTTATCAACTTGCGTTCTATTAGACCTTTAGATACTGAAGCTATCATCAAAACTGTCAAGAAGACAAACCACTTGATTACTGTTGAATCCACTTTCCCATCATTTGGTGTTGGTGCTGAAATTGTCGCCCAAGTTATGGAGTCTGAAGCCTTTGATTACTTGGATGCTCCAATCCAAAGAGTTACTGGTGCCGATGTTCCAACACCTTACGCTAAAGAATTAGAAGATTTCGCTTTCCCTGATACTCCAACCATCGTTAAAGCTGTCAAAGAAGTCTTGTCAATTGAATAA","protein_sequence":"MFSRLPTSLARNVARRAPTSFVRPSAAAAALRFSSTKTMTVREALNSAMAEELDRDDDVFLIGEEVAQYNGAYKVSKGLLDRFGERRVVDTPITEYGFTGLAVGAALKGLKPIVEFMSFNFSMQAIDHVVNSAAKTHYMSGGTQKCQMVFRGPNGAAVGVGAQHSQDFSPWYGSIPGLKVLVPYSAEDARGLLKAAIRDPNPVVFLENELLYGESFEISEEALSPEFTLPYKAKIEREGTDISIVTYTRNVQFSLEAAEILQKKYGVSAEVINLRSIRPLDTEAIIKTVKKTNHLITVESTFPSFGVGAEIVAQVMESEAFDYLDAPIQRVTGADVPTPYAKELEDFAFPDTPTIVKAVKEVLSIE"},{"created_at":"2011-05-27T03:14:42.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"D-lactate dehydrogenase [cytochrome] 3","uniprot_id":"P39976","uniprot_name":"DLD3_YEAST","enzyme":true,"transporter":false,"gene_name":"DLD3","num_residues":496,"molecular_weight":"55224.5","theoretical_pi":"6.88","general_function":"Involved in catalytic activity","specific_function":"(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c","reactions":[{"id":2712,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm;Mitochondrion inner membrane","altext":"(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.","export":false,"pw_reaction_id":null,"source":null},{"id":14119,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006550","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U18795","genbank_protein_id":"603247","gene_card_id":"DLD3","chromosome_location":"chromosome 5","locus":"YEL071W","synonyms":["D-lactate ferricytochrome C 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metabolism","kegg_map_id":"00620"}],"gene_sequence":"ATGACGGCCGCACATCCTGTTGCTCAGTTAACTGCCGAGGCATACCCTAAAGTCAAGAGAAACCCAAATTTCAAAGTTCTCGACTCGGAAGATTTGGCGTACTTTCGTTCGATTTTGTCAAATGATGAAATCTTAAACTCTCAAGCTCCAGAAGAGCTTGCTTCGTTTAACCAGGACTGGATGAAAAAATATAGAGGCCAGTCCAATTTAATTCTCTTGCCAAACTCCACTGATAAAGTGTCCAAGATTATGAAATACTGTAACGATAAAAAGTTGGCAGTAGTACCACAAGGTGGTAACACCGACTTGGTCGGAGCCTCTGTTCCGGTATTTGATGAGATTGTTCTTTCTCTAAGAAATATGAACAAAGTCAGAGATTTTGATCCAGTTAGCGGGACTTTCAAGTGTGACGCGGGTGTCGTTATGCGTGATGCGCATCAATTTTTACACGACCATGACCATATCTTCCCATTGGATCTGCCTTCTAGAAACAACTGTCAAGTGGGCGGTGTAGTTTCAACAAATGCAGGTGGTTTGAACTTTTTAAGATATGGGTCTCTACACGGTAATGTTTTGGGTTTGGAAGTGGTGCTACCCAACGGTGAGATTATCAGCAATATCAATGCCCTAAGGAAGGACAATACTGGTTATGACTTGAAACAATTATTCATCGGTGCAGAGGGTACTATCGGTGTCGTTACTGGTGTATCCATAGTTGCAGCAGCAAAGCCAAAAGCCTTGAATGCCGTATTTTTTGGTATTGAGAATTTCGATACCGTTCAGAAATTATTTGTCAAGGCTAAAAGTGAATTATCTGAGATTTTATCTGCTTTTGAATTCATGGACCGTGGCTCCATTGAATGTACGATAGAATACTTGAAGGACTTGCCTTTCCCTCTGGAGAACCAACACAACTTTTATGTTCTTATTGAAACGTCAGGGTCCAATAAGAGACACGACGATGAGAAGCTGACTGCTTTCCTCAAAGATACCACAGATTCTAAATTAATTTCGGAGGGTATGATGGCTAAGGACAAAGCCGATTTTGATAGACTTTGGACCTGGAGAAAATCTGTTCCAACAGCTTGTAATTCTTACGGTGGTATGTACAAGTATGACATGTCACTTCAATTGAAAGATTTATATTCCGTATCTGCGGCTGTGACGGAGAGATTAAACGCAGCCGGTTTGATTGGTGATGCACCAAAACCAGTTGTTAAATCATGTGGTTATGGTCATGTCGGTGACGGAAACATCCATTTAAATATCGCGGTAAGAGAATTTACAAAACAGATTGAGGACTTACTAGAACCATTTGTTTATGAATATATTGCATCAAAGAAAGGTTCCATCAGTGCTGAGCATGGGATCGGTTTCCATAAGAAAGGTAAGTTACACTACACCAGAAGTGATATTGAAATTAGATTTATGAAGGATATCAAAAATCACTACGATCCAAATGGAATCTTAAACCCATACAAGTACATTTGA","protein_sequence":"MTAAHPVAQLTAEAYPKVKRNPNFKVLDSEDLAYFRSILSNDEILNSQAPEELASFNQDWMKKYRGQSNLILLPNSTDKVSKIMKYCNDKKLAVVPQGGNTDLVGASVPVFDEIVLSLRNMNKVRDFDPVSGTFKCDAGVVMRDAHQFLHDHDHIFPLDLPSRNNCQVGGVVSTNAGGLNFLRYGSLHGNVLGLEVVLPNGEIISNINALRKDNTGYDLKQLFIGAEGTIGVVTGVSIVAAAKPKALNAVFFGIENFDTVQKLFVKAKSELSEILSAFEFMDRGSIECTIEYLKDLPFPLENQHNFYVLIETSGSNKRHDDEKLTAFLKDTTDSKLISEGMMAKDKADFDRLWTWRKSVPTACNSYGGMYKYDMSLQLKDLYSVSAAVTERLNAAGLIGDAPKPVVKSCGYGHVGDGNIHLNIAVREFTKQIEDLLEPFVYEYIASKKGSISAEHGIGFHKKGKLHYTRSDIEIRFMKDIKNHYDPNGILNPYKYI"},{"created_at":"2011-05-27T03:16:08.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Acetolactate synthase catalytic subunit, mitochondrial","uniprot_id":"P07342","uniprot_name":"ILVB_YEAST","enzyme":true,"transporter":false,"gene_name":"ILV2","num_residues":687,"molecular_weight":"74936.29688","theoretical_pi":"8.87","general_function":"Involved in magnesium ion binding","specific_function":"2 pyruvate = 2-acetolactate + CO(2)","reactions":[{"id":2713,"direction":"\u003e","locations":"Mitochondrion","altext":"2 pyruvate = 2-acetolactate + CO(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1T9D","cellular_location":"Mitochondrion","genbank_gene_id":"AY692995","genbank_protein_id":"51013441","gene_card_id":"ILV2","chromosome_location":"chromosome 13","locus":"YMR108W","synonyms":["Acetohydroxy-acid synthase catalytic subunit","AHAS","ALS"],"enzyme_classes":["2.2.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" thiamin pyrophosphate binding"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring aldehyde or ketonic groups"},{"category":"Function","description":" acetolactate synthase activity"},{"category":"Process","description":" cellular amino acid metabolic 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dehydrogenase [cytochrome] 2, mitochondrial","uniprot_id":"P46681","uniprot_name":"DLD2_YEAST","enzyme":true,"transporter":false,"gene_name":"DLD2","num_residues":530,"molecular_weight":"59268.0","theoretical_pi":"6.01","general_function":"Involved in catalytic activity","specific_function":"In addition to its enzymatic role it could play an important role in the yeast cell morphology","reactions":[{"id":2712,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm;Mitochondrion inner membrane","altext":"(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.","export":false,"pw_reaction_id":null,"source":null},{"id":14119,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006550","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY723765","genbank_protein_id":"51830216","gene_card_id":"DLD2","chromosome_location":"chromosome 4","locus":"YDL178W","synonyms":["Actin-interacting protein 2","D-lactate ferricytochrome C oxidoreductase","D-LCR"],"enzyme_classes":["1.1.2.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"FAD_binding_4","identifier":"PF01565"},{"name":"FAD-oxidase_C","identifier":"PF02913"}],"pathways":[{"name":"Pyruvate metabolism","kegg_map_id":"00620"}],"gene_sequence":"ATGCTAAGAAACATTTTGGTGAGAAGTACTGGCAGCAATTTCAAATTTGCTGGCAGATATATGAAATCATCAGCTCTTTTAGGATACTATAGAAGAGTTAACTATTATTCGACCAAGATACAAACCAGACTGACTAGCGAAAACTATCCAGACGTGCATCGAGACCCTAGATTCAAAAAATTAACGTCCGATGATCTAAATTATTTTAAATCTATTTTATCGGAACAAGAAATATTAAGAGCCAGCGAATCAGAGGATCTTTCATTTTATAATGAAGATTGGATGAGAAAGTACAAAGGACAGTCCAAGTTAGTATTGAGACCTAAGTCAGTGGAAAAAGTTTCTTTAATCTTAAATTATTGTAATGATGAAAAAATTGCCGTTGTCCCACAAGGCGGTAACACGGGGTTGGTAGGTGGTTCTGTGCCCATTTTTGATGAATTAATTCTATCTTTAGCAAATTTAAACAAAATAAGAGATTTTGACCCTGTATCAGGTATCTTGAAGTGTGATGCTGGTGTAATCTTGGAAAATGCTAACAATTACGTAATGGAACAAAATTATATGTTTCCGTTGGATCTGGGAGCTAAAGGTTCCTGCCATGTTGGTGGCGTGGTTGCAACCAACGCTGGAGGACTAAGGTTATTGCGTTATGGCTCACTACATGGAAGCGTTTTAGGCCTAGAGGTGGTAATGCCCAATGGTCAAATTGTTAGTAGCATGCATTCCATGAGAAAAGACAACACCGGTTATGATCTGAAACAGCTGTTCATTGGCTCAGAAGGTACTATCGGTATCATCACTGGTGTTTCAATCTTGACTGTTCCTAAGCCAAAAGCGTTTAATGTATCTTACTTGTCTGTTGAAAGTTTTGAAGACGTTCAAAAAGTCTTCGTCAGAGCCAGGCAAGAATTATCTGAGATTTTATCCGCTTTTGAATTTATGGATGCTAAATCTCAAGTATTGGCCAAGAGCCAATTGAAGGATGCTGCCTTCCCTTTGGAGGATGAGCATCCATTTTATATTCTTATCGAAACGTCAGGGTCAAACAAAGATCACGATGATTCCAAACTTGAAACATTTTTAGAAAACGTCATGGAAGAGGGCATAGTAACGGATGGTGTAGTGGCACAAGATGAAACCGAACTCCAAAACTTGTGGAAGTGGAGAGAAATGATTCCAGAGGCAAGTCAAGCTAATGGTGGTGTTTACAAATACGATGTTTCTTTACCACTAAAGGACCTATATTCTTTGGTTGAAGCCACTAATGCAAGACTTTCTGAAGCTGAATTAGTGGGTGATTCGCCCAAACCAGTGGTGGGCGCCATTGGATACGGTCACGTGGGTGATGGTAATCTACACTTAAATGTTGCAGTTAGAGAGTACAACAAGAACATTGAAAAGACTTTGGAACCATTTGTCTACGAGTTTGTTTCCTCAAAACATGGTTCCGTTAGTGCCGAACATGGGCTAGGTTTCCAAAAGAAAAATTACATTGGCTATTCTAAGAGCCCGGAAGAGGTCAAGATGATGAAGGATTTGAAGGTTCATTATGATCCTAATGGAATTTTAAACCCTTACAAATACATTTGA","protein_sequence":"MLRNILVRSTGSNFKFAGRYMKSSALLGYYRRVNYYSTKIQTRLTSENYPDVHRDPRFKKLTSDDLNYFKSILSEQEILRASESEDLSFYNEDWMRKYKGQSKLVLRPKSVEKVSLILNYCNDEKIAVVPQGGNTGLVGGSVPIFDELILSLANLNKIRDFDPVSGILKCDAGVILENANNYVMEQNYMFPLDLGAKGSCHVGGVVATNAGGLRLLRYGSLHGSVLGLEVVMPNGQIVNSMHSMRKDNTGYDLKQLFIGSEGTIGIITGVSILTVPKPKAFNVSYLSVESFEDVQKVFVRARQELSEILSAFEFMDAKSQVLAKSQLKDAAFPLEDEHPFYILIETSGSNKDHDDSKLETFLENVMEEGIVTDGVVAQDETELQNLWKWREMIPEASQANGGVYKYDVSLPLKDLYSLVEATNARLSEAELVGDSPKPVVGAIGYGHVGDGNLHLNVAVREYNKNIEKTLEPFVYEFVSSKHGSVSAEHGLGFQKKNYIGYSKSPEEVKMMKDLKVHYDPNGILNPYKYI"},{"created_at":"2011-05-27T07:27:50.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"Carboxylic acid transporter protein homolog","uniprot_id":"P36035","uniprot_name":"JEN1_YEAST","enzyme":false,"transporter":true,"gene_name":"JEN1","num_residues":616,"molecular_weight":"69375.60156","theoretical_pi":"5.72","general_function":"Involved in carbohydrate transmembrane transporter activity","specific_function":"Essential to lactate transport","reactions":[],"signal_regions":"None","transmembrane_regions":"141-161;177-197;206-226;231-251;264-284;297-317;364-384;403-423;433-453;458-478;490-510;536-556","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"U24155","genbank_protein_id":"780802","gene_card_id":"JEN1","chromosome_location":"chromosome 11","locus":"YKL217W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" carbohydrate transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Sugar_tr","identifier":"PF00083"}],"pathways":[],"gene_sequence":"ATGTCGTCGTCAATTACAGATGAGAAAATATCTGGTGAACAGCAACAACCTGCTGGCAGAAAACTATACTATAACACAAGTACATTTGCAGAGCCTCCTCTAGTGGACGGAGAAGGTAACCCTATAAATTATGAGCCGGAAGTTTACAACCCGGATCACGAAAAGCTATACCATAACCCATCACTGCCTGCACAATCAATTCAGGATACAAGAGATGATGAATTGCTGGAAAGAGTTTATAGCCAGGATCAAGGTGTAGAGTATGAGGAAGATGAAGAGGATAAGCCAAACCTAAGCGCTGCGTCCATTAAAAGTTATGCTTTAACGAGATTTACGTCCTTACTGCACATCCACGAGTTTTCTTGGGAGAATGTCAATCCCATACCCGAACTGCGCAAAATGACATGGCAGAATTGGAACTATTTTTTTATGGGTTATTTTGCGTGGTTGTCTGCGGCTTGGGCCTTCTTTTGCGTTTCAGTATCAGTCGCTCCATTGGCTGAACTATATGACAGACCAACCAAGGACATCACCTGGGGGTTGGGATTGGTGTTATTTGTTCGTTCAGCAGGTGCTGTCATATTTGGTTTATGGACAGATAAGTCTTCCAGAAAGTGGCCGTACATTACATGTTTGTTCTTATTTGTCATTGCACAACTCTGTACTCCATGGTGTGACACATACGAGAAATTTCTGGGCGTAAGGTGGATAACCGGTATTGCTATGGGAGGAATTTACGGATGTGCTTCTGCAACAGCGATTGAAGATGCACCTGTGAAAGCACGTTCGTTCCTATCAGGTCTATTTTTTTCTGCTTACGCTATGGGGTTCATATTTGCTATCATTTTTTACAGAGCCTTTGGCTACTTTAGGGATGATGGCTGGAAAATATTGTTTTGGTTTAGTATTTTTCTACCAATTCTACTAATTTTCTGGAGATTGTTATGGCCTGAAACGAAATACTTCACCAAGGTTTTGAAAGCCCGTAAATTAATATTGAGTGACGCAGTGAAAGCTAATGGTGGCGAGCCTCTACCAAAAGCCAACTTTAAACAAAAGATGGTATCCATGAAGAGAACAGTTCAAAAGTACTGGTTGTTGTTCGCATATTTGGTTGTTTTATTGGTGGGTCCAAATTACTTGACTCATGCTTCTCAAGACTTGTTGCCAACCATGCTGCGTGCCCAATTAGGCCTATCCAAGGATGCTGTCACTGTCATTGTAGTGGTTACCAACATCGGTGCTATTTGTGGGGGTATGATATTTGGACAGTTCATGGAAGTTACTGGAAGAAGATTAGGCCTATTGATTGCATGCACAATGGGTGGTTGCTTCACCTACCCTGCATTTATGTTGAGAAGCGAAAAGGCTATATTAGGTGCCGGTTTCATGTTATATTTTTGTGTCTTTGGTGTCTGGGGTATCCTGCCCATTCACCTTGCAGAGTTGGCCCCTGCTGATGCAAGGGCTTTGGTTGCCGGTTTATCTTACCAGCTAGGTAATCTAGCTTCTGCAGCGGCTTCCACGATTGAGACACAGTTAGCTGATAGATACCCATTAGAAAGAGATGCCTCTGGTGCTGTGATTAAAGAAGATTATGCCAAAGTTATGGCTATCTTGACTGGTTCTGTTTTCATCTTCACATTTGCTTGTGTTTTTGTTGGCCATGAGAAATTCCATCGTGATTTGTCCTCTCCTGTTATGAAGAAATATATAAACCAAGTGGAAGAATACGAAGCCGATGGTCTTTCGATTAGTGACATTGTTGAACAAAAGACGGAATGTGCTTCAGTGAAGATGATTGATTCGAACGTCTCAAAGACATATGAGGAGCATATTGAGACCGTTTAA","protein_sequence":"MSSSITDEKISGEQQQPAGRKLYYNTSTFAEPPLVDGEGNPINYEPEVYNPDHEKLYHNPSLPAQSIQDTRDDELLERVYSQDQGVEYEEDEEDKPNLSAASIKSYALTRFTSLLHIHEFSWENVNPIPELRKMTWQNWNYFFMGYFAWLSAAWAFFCVSVSVAPLAELYDRPTKDITWGLGLVLFVRSAGAVIFGLWTDKSSRKWPYITCLFLFVIAQLCTPWCDTYEKFLGVRWITGIAMGGIYGCASATAIEDAPVKARSFLSGLFFSAYAMGFIFAIIFYRAFGYFRDDGWKILFWFSIFLPILLIFWRLLWPETKYFTKVLKARKLILSDAVKANGGEPLPKANFKQKMVSMKRTVQKYWLLFAYLVVLLVGPNYLTHASQDLLPTMLRAQLGLSKDAVTVIVVVTNIGAICGGMIFGQFMEVTGRRLGLLIACTMGGCFTYPAFMLRSEKAILGAGFMLYFCVFGVWGILPIHLAELAPADARALVAGLSYQLGNLASAAASTIETQLADRYPLERDASGAVIKEDYAKVMAILTGSVFIFTFACVFVGHEKFHRDLSSPVMKKYINQVEEYEADGLSISDIVEQKTECASVKMIDSNVSKTYEEHIETV"},{"created_at":"2011-05-27T07:28:41.000Z","updated_at":"2011-05-29T05:06:46.000Z","name":"Cytochrome c iso-1","uniprot_id":"P00044","uniprot_name":"CYC1_YEAST","enzyme":true,"transporter":false,"gene_name":"CYC1","num_residues":109,"molecular_weight":"12181.90039","theoretical_pi":"9.96","general_function":"Involved in iron ion binding","specific_function":"Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain","reactions":[{"id":14426,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006939","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"2PCC","cellular_location":"Mitochondrion intermembrane space","genbank_gene_id":"L26347","genbank_protein_id":"695795","gene_card_id":"CYC1","chromosome_location":"chromosome 10","locus":"YJR048W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Cytochrom_C","identifier":"PF00034"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGACTGAATTCAAGGCCGGTTCTGCTAAGAAAGGTGCTACACTTTTCAAGACTAGATGTCTACAATGCCACACCGTGGAAAAGGGTGGCCCACATAAGGTTGGTCCAAACTTGCATGGTATCTTTGGCAGACACTCTGGTCAAGCTGAAGGGTATTCGTACACAGATGCCAATATCAAGAAAAACGTGTTGTGGGACGAAAATAACATGTCAGAGTACTTGACTAACCCAAAGAAATATATTCCTGGTACCAAGATGGCCTTTGGTGGGTTGAAGAAGGAAAAAGACAGAAACGACTTAATTACCTACTTGAAAAAAGCCTGTGAGTAA","protein_sequence":"MTEFKAGSAKKGATLFKTRCLQCHTVEKGGPHKVGPNLHGIFGRHSGQAEGYSYTDANIKKNVLWDENNMSEYLTNPKKYIPGTKMAFGGLKKEKDRNDLITYLKKACE"},{"created_at":"2011-05-27T07:29:16.000Z","updated_at":"2011-05-27T15:01:28.000Z","name":"Cytochrome c iso-2","uniprot_id":"P00045","uniprot_name":"CYC7_YEAST","enzyme":true,"transporter":false,"gene_name":"CYC7","num_residues":113,"molecular_weight":"12532.2998","theoretical_pi":"10.18","general_function":"Involved in iron ion binding","specific_function":"Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain","reactions":[{"id":14426,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006939","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1YEA","cellular_location":"Mitochondrion intermembrane space","genbank_gene_id":"AY693032","genbank_protein_id":"51013515","gene_card_id":"CYC7","chromosome_location":"chromosome 5","locus":"YEL039C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Cytochrom_C","identifier":"PF00034"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGGCTAAAGAAAGTACGGGATTCAAACCAGGCTCTGCAAAAAAGGGTGCTACATTGTTTAAAACGAGGTGTCAGCAGTGTCATACAATAGAAGAGGGTGGTCCTAACAAAGTTGGACCTAATTTACATGGTATTTTTGGTAGACATTCAGGTCAGGTAAAGGGTTATTCTTACACAGATGCAAACATCAACAAGAACGTCAAATGGGATGAGGATAGTATGTCCGAGTACTTGACGAACCCAAAGAAATATATTCCTGGTACCAAGATGGCGTTTGCCGGGTTGAAGAAGGAAAAGGACAGAAACGATTTAATTACTTATATGACAAAGGCTGCCAAATAG","protein_sequence":"MAKESTGFKPGSAKKGATLFKTRCQQCHTIEEGGPNKVGPNLHGIFGRHSGQVKGYSYTDANINKNVKWDEDSMSEYLTNPKKYIPGTKMAFAGLKKEKDRNDLITYMTKAAK"},{"created_at":"2011-05-29T03:30:17.000Z","updated_at":"2011-05-29T05:06:53.000Z","name":"D-serine dehydratase","uniprot_id":"P53095","uniprot_name":"DSD1_YEAST","enzyme":true,"transporter":false,"gene_name":"DSD1","num_residues":428,"molecular_weight":"47827.39844","theoretical_pi":"7.64","general_function":"Involved in D-serine ammonia-lyase activity","specific_function":"Converts specifically D-serine to pyruvate and ammonia. May play a role in D-serine detoxification","reactions":[{"id":2838,"direction":"\u003e","locations":null,"altext":"D-serine = pyruvate + NH(3).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"DSD1","chromosome_location":"chromosome 7","locus":"YGL196W","synonyms":["D-serine deaminase","DSD"],"enzyme_classes":["4.3.1.18"],"go_classes":[],"pfams":[{"name":"Ala_racemase_N","identifier":"PF01168"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"}],"gene_sequence":"ATGAGCGATGTTCTATCTCAATATAAAGGGTGCTCAGTCAGAGATTTACCCACACCCAATTTCGTTATTAATGAAGAAAAATTTGATAAGAATTGTACGACAATGTTGAACAACGTTGAAAAGCTCAGCCAGGAATGTGGCGTACCAATCAAATTTCGTGCACACGTAAAAACGCATAAGACAGCAAAGGGAACTTTGAAACAATTGGGCCACGGACTTCCATTGGCTAAACGCACTACAAGAGCCATATTAGTATCAACTTTGAAAGAAGCAGAAGAACTTCTTAATTATCAAGATAGACAATGTTCGGATTATATTGACGATATAACATATAGTTTACCCTGTTGCGTTCCAGAGTTTATTCCTCTTTTGAGCAATTTGTCAAGAAGGGTGAATAATTTTCAGGTTTTTGTTGATAACATTGAACACTTGGAGAATTTAAAGAATTTCGGTAGGCCTGCTTCCGGCAAGAAATGGTCGGTTTTTATCAAGGTTGATATGGGGACTAAGAGGGCAGGTCTTGCTTTCGACTCTCCAGAATTTTTGAGTCTTTTAAAAAAACTGACTTCCTCAGAAATTAAAGAAGTAATTGAGCCATATGGGTTTTATGCTCATGCCGGACACAGCTACTCTTCAACCTCGATCAACGACACTCAGAATCTTTTGATGGAAGAAGTGAAAGCAGTCAATTCTGCCGCTAAAGTTTTGTGCTCTGTGGATCCTCAGTTTGATCCTTCTAAATTAACACTTTCTGTGGGCGCTACTCCGACTTCCAATTCTTTGAAACTCGATAATAAAAGTACCCTTGTTAAATTCATTACTACTCAATTAGTTAGTACGCTTGAAATCCACTGCGGTAATTACTGCATGTATGACCTGCAACAGGTGGCAACAGGCTGTGTCCAAGATCACGAATTGTCTGGTTTTGTATTAGGAACAGTACTATCATCTTACCCTTCTAGAGGTGAATTGTTGAGTAATACAGGTGTAATGTGTCTAACGCGAGAAGCATCCTCAATAAAAGGGTTTGGAATATGTGCTGATTTGGAACATGTGTTAAAATCCGAGAGTTTCAGTAGGGAATGGTATGTAGCAAGGGTCTCTCAAGAACACGGGATACTGAGGCCAATAAGAAACTGGAACGAAACTACTCCATTAAAATTAGGCAGCAAAATTGCCGTCCTTCCTCAACACGCTTGTATCACAATGGGACAATTTCCATATTATTTCGTGGTAAACAGCGAAGGCATTGTCAACGATGTTTGGTTACCTTTTCAGAAATGGTAA","protein_sequence":"MSDVLSQYKGCSVRDLPTPNFVINEEKFDKNCTTMLNNVEKLSQECGVPIKFRAHVKTHKTAKGTLKQLGHGLPLAKRTTRAILVSTLKEAEELLNYQDRQCSDYIDDITYSLPCCVPEFIPLLSNLSRRVNNFQVFVDNIEHLENLKNFGRPASGKKWSVFIKVDMGTKRAGLAFDSPEFLSLLKKLTSSEIKEVIEPYGFYAHAGHSYSSTSINDTQNLLMEEVKAVNSAAKVLCSVDPQFDPSKLTLSVGATPTSNSLKLDNKSTLVKFITTQLVSTLEIHCGNYCMYDLQQVATGCVQDHELSGFVLGTVLSSYPSRGELLSNTGVMCLTREASSIKGFGICADLEHVLKSESFSREWYVARVSQEHGILRPIRNWNETTPLKLGSKIAVLPQHACITMGQFPYYFVVNSEGIVNDVWLPFQKW"},{"created_at":"2011-05-29T04:45:54.000Z","updated_at":"2011-07-22T17:53:48.000Z","name":"Aminodeoxychorismate lyase","uniprot_id":"Q03266","uniprot_name":"PABC_YEAST","enzyme":true,"transporter":false,"gene_name":"ABZ2","num_residues":374,"molecular_weight":"42639.39844","theoretical_pi":"5.53","general_function":"Involved in catalytic activity","specific_function":"Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate","reactions":[{"id":1191,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2848,"direction":"\u003e","locations":"Cytoplasm","altext":"4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate.","export":false,"pw_reaction_id":null,"source":null},{"id":4144,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006445","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"ABZ2","chromosome_location":"chromosome 13","locus":"YMR289W","synonyms":["4-amino-4-deoxychorismate lyase","ADC lyase","ADCL"],"enzyme_classes":["4.1.3.38"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Aminotran_4","identifier":"PF01063"}],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"},{"name":"tetrahydrofolate 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dehydrogenase complex protein X component, mitochondrial","uniprot_id":"P16451","uniprot_name":"ODPX_YEAST","enzyme":false,"transporter":false,"gene_name":"PDX1","num_residues":410,"molecular_weight":"45361.30078","theoretical_pi":"5.41","general_function":"Energy production and conversion","specific_function":"Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex","reactions":[{"id":3693,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003279","source":"Smpdb"},{"id":3694,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006559","source":"Smpdb"},{"id":3695,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006560","source":"Smpdb"},{"id":3696,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006561","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"M28222","genbank_protein_id":"172268","gene_card_id":"PDX1","chromosome_location":null,"locus":null,"synonyms":["Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex","E3-binding protein","Pyruvate dehydrogenase complex component E3BP"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":"acyltransferase activity"},{"category":"Function","description":"protein binding"},{"category":"Function","description":"binding"},{"category":"Function","description":"catalytic activity"},{"category":"Function","description":"transferase activity"},{"category":"Function","description":"transferase activity, transferring acyl groups"},{"category":"Process","description":"metabolic process"}],"pfams":[{"name":"Biotin_lipoyl","identifier":"PF00364"}],"pathways":[{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGCTAAGTGCAATTTCCAAAGTCTCCACTTTAAAATCATGTACAAGATATTTAACCAAATGCAACTATCATGCATCAGCTAAATTACTTGCTGTAAAGACATTTTCAATGCCTGCAATGTCTCCTACTATGGAGAAAGGGGGGATTGTGTCTTGGAAATATAAAGTTGGCGAACCATTCAGCGCGGGCGATGTGATATTAGAAGTGGAAACAGATAAATCTCAAATTGATGTGGAAGCACTGGACGATGGTAAACTAGCTAAGATCCTGAAAGATGAAGGCTCTAAAGATGTTGATGTTGGTGAACCTATTGCTTATATTGCTGATGTTGATGATGATTTAGCTACTATAAAGTTACCCCAAGAGGCCAACACCGCAAATGCGAAATCTATTGAAATTAAGAAGCCATCCGCAGATAGTACTGAAGCAACACAACAACATTTAAAAAAAGCCACAGTTACACCAATAAAAACCGTTGACGGCAGCCAAGCCAATCTTGAACAGACGCTATTACCATCCGTGTCATTACTACTGGCTGAGAACAATATATCCAAACAAAAGGCTTTGAAGGAAATTGCGCCATCTGGTTCCAACGGTAGACTATTAAAGGGTGATGTGCTAGCATACCTAGGGAAAATACCACAAGATTCGGTTAACAAGGTAACAGAATTTATCAAGAAGAACGAACGTCTCGATTTATCGAACATTAAACCTATACAGCTCAAACCAAAAATAGCCGAGCAAGCTCAAACAAAAGCTGCCGACAAGCCAAAGATTACTCCTGTAGAATTTGAAGAGCAATTAGTGTTCCATGCTCCCGCCTCTATTCCGTTTGACAAACTGAGTGAATCATTGAACTCTTTCATGAAAGAAGCTTACCAGTTCTCACACGGAACACCACTAATGGACACAAATTCGAAATACTTTGACCCTATTTTCGAGGACCTTGTCACCTTGAGCCCAAGAGAGCCAAGATTTAAATTTTCCTATGACTTGATGCAAATTCCCAAAGCTAATAACATGCAAGACACGTACGGTCAAGAAGACATATTTGACCTCTTAACAGGTTCAGACGCGACTGCCTCATCAGTAAGACCCGTTGAAAAGAACTTACCTGAAAAAAACGAATATATACTAGCGTTGAATGTTAGCGTCAACAACAAGAAGTTTAATGACGCGGAGGCCAAGGCAAAAAGATTCCTTGATTACGTAAGGGAGTTAGAATCATTTTGA","protein_sequence":"MLSAISKVSTLKSCTRYLTKCNYHASAKLLAVKTFSMPAMSPTMEKGGIVSWKYKVGEPFSAGDVILEVETDKSQIDVEALDDGKLAKILKDEGSKDVDVGEPIAYIADVDDDLATIKLPQEANTANAKSIEIKKPSADSTEATQQHLKKATVTPIKTVDGSQANLEQTLLPSVSLLLAENNISKQKALKEIAPSGSNGRLLKGDVLAYLGKIPQDSVNKVTEFIKKNERLDLSNIKPIQLKPKIAEQAQTKAADKPKITPVEFEEQLVFHAPASIPFDKLSESLNSFMKEAYQFSHGTPLMDTNSKYFDPIFEDLVTLSPREPRFKFSYDLMQIPKANNMQDTYGQEDIFDLLTGSDATASSVRPVEKNLPEKNEYILALNVSVNNKKFNDAEAKAKRFLDYVRELESF"}]}