{"ymdb_id":"YMDB00446","created_at":"2011-05-29T18:17:56.000Z","updated_at":"2016-09-08T18:35:29.000Z","name":"propionyl-CoA","cas":"317-66-8","state":"Solid","melting_point":null,"description":"Propionyl-CoA is a coenzyme A derivative of propionic acid. There are several different ways in which it is formed:\n1) as a product of beta-oxidation of odd-chain fatty acids, 2) as a product of metabolism of isoleucine and valine or, 3)\nas a product of alpha-ketobutyric acid, which in turn is a product of threonine and methionine metabolism. [Wikipidia]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"mitochondrion;lipid particle;endoplasmic reticulum","synthesis_reference":"Sokatch, John R.; Sanders, Lois E.; Marshall, Vincent P.  Oxidation of methylmalonate semialdehyde to propionyl coenzyme A in Pseudomonas aeruginosa grown on valine.    Journal of Biological Chemistry  (1968),  243(10),  2500-6.","chebi_id":"15539","hmdb_id":"HMDB01275","kegg_id":"C00100","pubchem_id":"439164","cs_id":"24784993","foodb_id":null,"wikipedia_link":"Propionyl-CoA","biocyc_id":"PROPIONYL-COA","iupac":"{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-[(2-{[2-(propanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid","traditional_iupac":"propionyl-coa","logp":"-5.181083266147958","pka":"1.9001207347761846","alogps_solubility":"4.27e+00 g/l","alogps_logp":"-0.31","alogps_logs":"-2.29","acceptor_count":"17","donor_count":"9","rotatable_bond_count":"21","polar_surface_area":"363.6299999999999","refractivity":"176.8349","polarizability":"74.36560916669288","formal_charge":"0","physiological_charge":"-4","pka_strongest_basic":"4.006053268556904","pka_strongest_acidic":"0.8209787813398228","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["2-methylacetyl-CoA","2-methylacetyl-Coenzyme A","alpha-methylacetyl-CoA","alpha-methylacetyl-Coenzyme A","n-propionyl-CoA","n-propionyl-coenzyme A","propanoyl-CoA","propanoyl-Coenzyme A","propionyl coenzyme a","Propionyl-CoA","propionyl-coenzyme A","S-Propionyl-coenzym-A","S-Propionylcoenzyme A"],"pathways":[{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"Glycerolipid metabolism","kegg_map_id":"00561"},{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":7912143,"citation":"Pronk, J. T., van der Linden-Beuman, A., Verduyn, C., Scheffers, W. A., van Dijken, J. P. (1994). \"Propionate metabolism in Saccharomyces cerevisiae: implications for the metabolon hypothesis.\" Microbiology 140 ( Pt 4):717-722."},{"pubmed_id":16332871,"citation":"Singh, J., Kumar, D., Ramakrishnan, N., Singhal, V., Jervis, J., Garst, J. F., Slaughter, S. M., DeSantis, A. M., Potts, M., Helm, R. F. (2005). \"Transcriptional response of Saccharomyces cerevisiae to desiccation and rehydration.\" Appl Environ Microbiol 71:8752-8763."}],"proteins":[{"created_at":"2011-05-24T21:50:30.000Z","updated_at":"2011-07-22T17:53:55.000Z","name":"Acetyl-coenzyme A synthetase 1","uniprot_id":"Q01574","uniprot_name":"ACS1_YEAST","enzyme":true,"transporter":false,"gene_name":"ACS1","num_residues":713,"molecular_weight":"79140.10156","theoretical_pi":"6.6","general_function":"Involved in acetate-CoA ligase activity","specific_function":"Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. \"Aerobic\" isozyme of acetyl-coenzyme A synthetase, which supports growth on nonfermentable carbon sources such as glycerol and ethanol. May be required for assimilation of ethanol and acetate","reactions":[{"id":1242,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2397,"direction":"\u003e","locations":"Cytoplasm. Nucleus.;Microsome (Potential). Cytoplasm. Mitochondrion. Nucleus","altext":"ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":14126,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006563","source":"Smpdb"},{"id":14127,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006564","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1RY2","cellular_location":"Microsome (Potential). Cytoplasm. Mitochondrion. Nucleus","genbank_gene_id":"AY723758","genbank_protein_id":"51830202","gene_card_id":"ACS1","chromosome_location":"chromosome 1","locus":"YAL054C","synonyms":["Acetate--CoA ligase 1","Acyl-activating enzyme 1"],"enzyme_classes":["6.2.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ligase activity, forming carbon-sulfur bonds"},{"category":"Function","description":" CoA-ligase activity"},{"category":"Function","description":" AMP binding"},{"category":"Function","description":" acetate-CoA ligase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"AMP-binding","identifier":"PF00501"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"gene_sequence":"ATGTCGCCCTCTGCCGTACAATCATCAAAACTAGAAGAACAGTCAAGTGAAATTGACAAGTTGAAAGCAAAAATGTCCCAGTCTGCCGCCACTGCGCAGCAGAAGAAGGAACATGAGTATGAACATTTGACTTCGGTCAAGATCGTGCCACAACGGCCCATCTCAGATAGACTGCAGCCCGCAATTGCTACCCACTATTCTCCACACTTGGACGGGTTGCAGGACTATCAGCGCTTGCACAAGGAGTCTATTGAAGACCCTGCTAAGTTCTTCGGTTCTAAAGCTACCCAATTTTTAAACTGGTCTAAGCCATTCGATAAGGTGTTCATCCCAGACCCTAAAACGGGCAGGCCCTCCTTCCAGAACAATGCATGGTTCCTCAACGGCCAATTAAACGCCTGTTACAACTGTGTTGACAGACATGCCTTGAAGACTCCTAACAAGAAAGCCATTATTTTCGAAGGTGACGAGCCTGGCCAAGGCTATTCCATTACCTACAAGGAACTACTTGAAGAAGTTTGTCAAGTGGCACAAGTGCTGACTTACTCTATGGGCGTTCGCAAGGGCGATACTGTTGCCGTGTACATGCCTATGGTCCCAGAAGCAATCATAACCTTGTTGGCCATTTCCCGTATCGGTGCCATTCACTCCGTAGTCTTTGCCGGGTTTTCTTCCAACTCCTTGAGAGATCGTATCAACGATGGGGACTCTAAAGTTGTCATCACTACAGATGAATCCAACAGAGGTGGTAAAGTCATTGAGACTAAAAGAATTGTTGATGACGCGCTAAGAGAGACCCCAGGCGTGAGACACGTCTTGGTTTATAGAAAGACCAACAATCCATCTGTTGCTTTCCATGCCCCCAGAGATTTGGATTGGGCAACAGAAAAGAAGAAATACAAGACCTACTATCCATGCACACCCGTTGATTCTGAGGATCCATTATTCTTGTTGTATACGTCTGGTTCTACTGGTGCCCCCGAGGGTGTTCAACATTCTACCGCAGGTTACTTGCTGGGAGCTTTGTTGACCATGCGCTACACTTTTGACACTCACCAAGAAGACGTTTTCTTCACAGCTGGAGACATTGGCTGGATTACAGGCCACACTTATGTGGTTTATGGTCCCTTACTATATGGTTGTGCCACTTTGGTCTTTGAAGGGACTCCTGCGTACCCAAATTACTCCCGTTATTGGGATATTATTGATGAACACAAAGTCACCCAATTTTATGTTGCGCCAACTGCTTTGCGTTTGTTGAAAAGAGCTGGTGATTCCTACATCGAAAATCATTCCTTAAAATCTTTGCGTTGCTTGGGTTCGGTCGGTGAGCCAATTGCTGCTGAAGTTTGGGAGTGGTACTCTGAAAAAATAGGTAAAAATGAAATCCCCATTGTAGACACCTACTGGCAAACAGAATCTGGTTCGCATCTGGTCACCCCGCTGGCTGGTGGTGTTACACCAATGAAACCGGGTTCTGCCTCATTCCCCTTCTTCGGTATTGATGCAGTTGTTCTTGACCCTAACACTGGTGAAGAACTTAACACCAGCCACGCAGAGGGTGTCCTTGCCGTCAAAGCTGCATGGCCATCATTTGCAAGAACTATTTGGAAAAATCATGATAGGTATCTAGACACTTATTTGAACCCTTACCCTGGCTACTATTTCACTGGTGATGGTGCTGCAAAGGATAAGGATGGTTATATCTGGATTTTGGGTCGTGTAGACGATGTGGTGAACGTCTCTGGTCACCGTCTGTCTACCGCTGAAATTGAGGCTGCTATTATCGAAGATCCAATTGTGGCCGAGTGTGCTGTTGTCGGATTCAACGATGACTTGACTGGTCAAGCAGTTGCTGCATTTGTGGTGTTGAAAAACAAATCTAGTTGGTCCACCGCAACAGATGATGAATTACAAGATATCAAGAAGCATTTGGTCTTTACTGTTAGAAAAGACATCGGGCCATTTGCCGCACCAAAATTGATCATTTTAGTGGATGACTTGCCCAAGACAAGATCCGGCAAAATTATGAGACGTATTTTAAGAAAAATCCTAGCAGGAGAAAGTGACCAACTAGGCGACGTTTCTACATTGTCAAACCCTGGCATTGTTAGACATCTAATTGATTCGGTCAAGTTGTAA","protein_sequence":"MSPSAVQSSKLEEQSSEIDKLKAKMSQSAATAQQKKEHEYEHLTSVKIVPQRPISDRLQPAIATHYSPHLDGLQDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIPDPKTGRPSFQNNAWFLNGQLNACYNCVDRHALKTPNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAGESDQLGDVSTLSNPGIVRHLIDSVKL"},{"created_at":"2011-05-24T21:52:26.000Z","updated_at":"2011-07-22T17:53:55.000Z","name":"Acetyl-coenzyme A synthetase 2","uniprot_id":"P52910","uniprot_name":"ACS2_YEAST","enzyme":true,"transporter":false,"gene_name":"ACS2","num_residues":683,"molecular_weight":"75491.10156","theoretical_pi":"6.67","general_function":"Involved in acetate-CoA ligase activity","specific_function":"Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. \"Anaerobic\" isozyme of acetyl-coenzyme A synthetase, which is required for growth on fermentable carbon sources such as glucose. May be involved in the PDH (pyruvate dehydrogenase complex) bypass","reactions":[{"id":1242,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1243,"direction":"\u003c\u003e","locations":"nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2397,"direction":"\u003e","locations":"Cytoplasm. Nucleus.;Microsome (Potential). Cytoplasm. Mitochondrion. Nucleus","altext":"ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":14126,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006563","source":"Smpdb"},{"id":14127,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006564","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus.","genbank_gene_id":"S79456","genbank_protein_id":"1168014","gene_card_id":"ACS2","chromosome_location":"chromosome 12","locus":"YLR153C","synonyms":["Acetate--CoA ligase 2","Acyl-activating enzyme 2"],"enzyme_classes":["6.2.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ligase activity, forming carbon-sulfur bonds"},{"category":"Function","description":" CoA-ligase activity"},{"category":"Function","description":" AMP binding"},{"category":"Function","description":" acetate-CoA ligase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"AMP-binding","identifier":"PF00501"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"gene_sequence":"ATGACAATCAAGGAACATAAAGTAGTTTATGAAGCTCACAACGTAAAGGCTCTTAAGGCTCCTCAACATTTTTACAACAGCCAACCCGGCAAGGGTTACGTTACTGATATGCAACATTATCAAGAAATGTATCAACAATCTATCAATGAGCCAGAAAAATTCTTTGATAAGATGGCTAAGGAATACTTGCATTGGGATGCTCCATACACCAAAGTTCAATCTGGTTCATTGAACAATGGTGATGTTGCATGGTTTTTGAACGGTAAATTGAATGCATCATACAATTGTGTTGACAGACATGCCTTTGCTAATCCCGACAAGCCAGCTTTGATCTATGAAGCTGATGACGAATCCGACAACAAAATCATCACATTTGGTGAATTACTCAGAAAAGTTTCCCAAATCGCTGGTGTCTTAAAAAGCTGGGGCGTTAAGAAAGGTGACACAGTGGCTATCTATTTGCCAATGATTCCAGAAGCGGTCATTGCTATGTTGGCTGTGGCTCGTATTGGTGCTATTCACTCTGTTGTCTTTGCTGGGTTCTCCGCTGGTTCGTTGAAAGATCGTGTCGTTGACGCTAATTCTAAAGTGGTCATCACTTGTGATGAAGGTAAAAGAGGTGGTAAGACCATCAACACTAAAAAAATTGTTGACGAAGGTTTGAACGGAGTCGATTTGGTTTCCCGTATCTTGGTTTTCCAAAGAACTGGTACTGAAGGTATTCCAATGAAGGCCGGTAGAGATTACTGGTGGCATGAGGAGGCCGCTAAGCAGAGAACTTACCTACCTCCTGTTTCATGTGACGCTGAAGATCCTCTATTTTTATTATACACTTCCGGTTCCACTGGTTCTCCAAAGGGTGTCGTTCACACTACAGGTGGTTATTTATTAGGTGCCGCTTTAACAACTAGATACGTTTTTGATATTCACCCAGAAGATGTTCTCTTCACTGCCGGTGACGTCGGCTGGATCACGGGTCACACCTATGCTCTATATGGTCCATTAACCTTGGGTACCGCCTCAATAATTTTCGAATCCACTCCTGCCTACCCAGATTATGGTAGATATTGGAGAATTATCCAACGTCACAAGGCTACCCATTTCTATGTGGCTCCAACTGCTTTAAGATTAATCAAACGTGTAGGTGAAGCCGAAATTGCCAAATATGACACTTCCTCATTACGTGTCTTGGGTTCCGTCGGTGAACCAATCTCTCCAGACTTATGGGAATGGTATCATGAAAAAGTGGGTAACAAAAACTGTGTCATTTGTGACACTATGTGGCAAACAGAGTCTGGTTCTCATTTAATTGCTCCTTTGGCAGGTGCTGTCCCAACAAAACCTGGTTCTGCTACCGTGCCATTCTTTGGTATTAACGCTTGTATCATTGACCCTGTTACAGGTGTGGAATTAGAAGGTAATGATGTCGAAGGTGTCCTTGCCGTTAAATCACCATGGCCATCAATGGCTAGATCTGTTTGGAACCACCACGACCGTTACATGGATACTTACTTGAAACCTTATCCTGGTCACTATTTCACAGGTGATGGTGCTGGTAGAGATCATGATGGTTACTACTGGATCAGGGGTAGAGTTGACGACGTTGTAAATGTTTCCGGTCATAGATTATCCACATCAGAAATTGAAGCATCTATCTCAAATCACGAAAACGTCTCGGAAGCTGCTGTTGTCGGTATTCCAGATGAATTGACCGGTCAAACCGTCGTTGCATATGTTTCCCTAAAAGATGGTTATCTACAAAACAACGCTACTGAAGGTGATGCAGAACACATCACACCAGATAATTTACGTAGAGAATTGATCTTACAAGTTAGGGGTGAGATTGGTCCTTTCGCCTCACCAAAAACCATTATTCTAGTTAGAGATCTACCAAGAACAAGGTCAGGAAAGATTATGAGAAGAGTTCTAAGAAAGGTTGCTTCTAACGAAGCCGAACAGCTAGGTGACCTAACTACTTTGGCCAACCCAGAAGTTGTACCTGCCATCATTTCTGCTGTAGAGAACCAATTTTTCTCTCAAAAAAAGAAATAA","protein_sequence":"MTIKEHKVVYEAHNVKALKAPQHFYNSQPGKGYVTDMQHYQEMYQQSINEPEKFFDKMAKEYLHWDAPYTKVQSGSLNNGDVAWFLNGKLNASYNCVDRHAFANPDKPALIYEADDESDNKIITFGELLRKVSQIAGVLKSWGVKKGDTVAIYLPMIPEAVIAMLAVARIGAIHSVVFAGFSAGSLKDRVVDANSKVVITCDEGKRGGKTINTKKIVDEGLNGVDLVSRILVFQRTGTEGIPMKAGRDYWWHEEAAKQRTYLPPVSCDAEDPLFLLYTSGSTGSPKGVVHTTGGYLLGAALTTRYVFDIHPEDVLFTAGDVGWITGHTYALYGPLTLGTASIIFESTPAYPDYGRYWRIIQRHKATHFYVAPTALRLIKRVGEAEIAKYDTSSLRVLGSVGEPISPDLWEWYHEKVGNKNCVICDTMWQTESGSHLIAPLAGAVPTKPGSATVPFFGINACIIDPVTGVELEGNDVEGVLAVKSPWPSMARSVWNHHDRYMDTYLKPYPGHYFTGDGAGRDHDGYYWIRGRVDDVVNVSGHRLSTSEIEASISNHENVSEAAVVGIPDELTGQTVVAYVSLKDGYLQNNATEGDAEHITPDNLRRELILQVRGEIGPFASPKTIILVRDLPRTRSGKIMRRVLRKVASNEAEQLGDLTTLANPEVVPAIISAVENQFFSQKKK"},{"created_at":"2011-05-26T16:05:55.000Z","updated_at":"2011-07-22T17:54:31.000Z","name":"Citrate synthase 3","uniprot_id":"P43635","uniprot_name":"CISY3_YEAST","enzyme":true,"transporter":false,"gene_name":"CIT3","num_residues":486,"molecular_weight":"53810.69922","theoretical_pi":"8.79","general_function":"Involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer","specific_function":"Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA","reactions":[{"id":1151,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1411,"direction":"\u003e","locations":"mitochondrion;peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2408,"direction":"\u003e","locations":"Peroxisome;Mitochondrion matrix","altext":"Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":2409,"direction":"\u003e","locations":null,"altext":"propanoyl-CoA + H2O + oxaloacetate = (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA","export":false,"pw_reaction_id":null,"source":null},{"id":3697,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003280","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U31900","genbank_protein_id":"939735","gene_card_id":"CIT3","chromosome_location":"chromosome 16","locus":"YPR001W","synonyms":[],"enzyme_classes":["2.3.3.1","2.3.3.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Process","description":" cellular carbohydrate metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"}],"pfams":[{"name":"Citrate_synt","identifier":"PF00285"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGGTACAAAGGCTTCTACCGGGCGCACATATATGCAGAAGGTCCTTCAATTCGTCTGCAATTATAAAGTCTTCTGCATTGACTCTCAAGGAAGCATTAGAAAACGTGATACCTAAGAAAAGAGATGCTGTGAAGAAATTGAAGGCCTGTTATGGCAGCACGTTTGTCGGACCGATTACCATTTCATCAGTTCTAGGTGGGATGAGAGGTAATCAGTCAATGTTTTGGCAAGGAACATCATTAGATCCCGAACATGGCATTAAATTTCAAGGTTTAACGATTGAAGAATGTCAAAATAGATTACCTAATACAGGTATTGATGGCGATAATTTCCTGCCAGAATCAATGTTATGGCTGTTGATGACAGGTGGTGTGCCAACTTTCCAGCAAGCTGCTTCTTTCAGGAAAGAATTGGCTATTCGTGGAAGGAAATTGCCACATTATACAGAGAAAGTTTTGTCAAGTTTACCCAAAGATATGCACCCTATGACCCAACTTGCAATTGGTTTAGCATCAATGAACAAAGGATCCCTCTTTGCTACAAACTACCAAAAGGGCCTCATAGGAAAGATGGAATTTTGGAAAGATACTCTTGAAGATTCGCTAAATTTAATTGCTTCACTCCCGCTGCTGACTGGGAGAATTTATTCGAACATTACAAATGAGGGACACCCATTAGGTCAATATAGTGAGGAGGTGGATTGGTGTACAAACATATGTTCCCTGCTCGGCATGACAAATGGAACGAACTCTTCTAATACATGCAACCTTACTTCCCAGCAATCCCTGGACTTCATAAACTTGATGCGGTTATATACCGGTATACATGTAGACCATGAAGGTGGTAATGTTTCTGCTCACACCACCCACTTGGTTGGAAGTGCGTTGAGTGACCCGTATCTCAGCTATTCATCTGGAATAATGGGATTAGCGGGTCCTTTGCATGGGTTAGCAGCACAAGAAGTAGTAAGGTTTCTCATAGAGATGAACTCTAATATTTCCAGCATTGCACGAGAACAAGAAATCAAAGATTATCTTTGGAAAATTTTGAATTCAAACCGTGTGATCCCCGGTTATGGGCACGCAGTTTTGCGTAAACCGGATCCTCGATTTACAGCAATGCTTGAATTTGCGCAAAAGAGGCCTATTGAATTTGAGAACGACAAGAACGTTTTGTTGATGCAAAAATTGGCAGAAATAGCGCCTAAGGTTTTGTTGGAACACGGAAAGAGTAAGAATCCATTTCCCAATGTTGACTCTGCATCGGGGATTTTGTTTTATCATTATGGAATCAGGGAATTATTATTCTTTACCGTCATTTTTGGGTGTTCAAGGGCCATGGGACCCTTGACACAACTTGTTTGGGATCGCATTCTAGGTTTACCAATTGAAAGGCCCAAGAGTTTGAACTTGGAGGGTCTGGAAGCACTTACCAAAGCAAGCAATGTTAACAAGTTGTAA","protein_sequence":"MVQRLLPGAHICRRSFNSSAIIKSSALTLKEALENVIPKKRDAVKKLKACYGSTFVGPITISSVLGGMRGNQSMFWQGTSLDPEHGIKFQGLTIEECQNRLPNTGIDGDNFLPESMLWLLMTGGVPTFQQAASFRKELAIRGRKLPHYTEKVLSSLPKDMHPMTQLAIGLASMNKGSLFATNYQKGLIGKMEFWKDTLEDSLNLIASLPLLTGRIYSNITNEGHPLGQYSEEVDWCTNICSLLGMTNGTNSSNTCNLTSQQSLDFINLMRLYTGIHVDHEGGNVSAHTTHLVGSALSDPYLSYSSGIMGLAGPLHGLAAQEVVRFLIEMNSNISSIAREQEIKDYLWKILNSNRVIPGYGHAVLRKPDPRFTAMLEFAQKRPIEFENDKNVLLMQKLAEIAPKVLLEHGKSKNPFPNVDSASGILFYHYGIRELLFFTVIFGCSRAMGPLTQLVWDRILGLPIERPKSLNLEGLEALTKASNVNKL"},{"created_at":"2011-05-26T23:37:41.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"N-acetyltransferase HPA3","uniprot_id":"P39979","uniprot_name":"HPA3_YEAST","enzyme":true,"transporter":false,"gene_name":"HPA3","num_residues":179,"molecular_weight":"20698.5","theoretical_pi":"7.84","general_function":"Involved in N-acetyltransferase activity","specific_function":"N-acetyltransferase whose physiological acetyl acceptor substrate is still unknown. In vitro, histone acetylation is very weak","reactions":[{"id":2617,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino acid","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U18795","genbank_protein_id":"603252","gene_card_id":"HPA3","chromosome_location":"chromosome 5","locus":"YEL066W","synonyms":[],"enzyme_classes":["2.3.1.-","2.3.1.36"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" acetyltransferase activity"},{"category":"Function","description":" N-acetyltransferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Acetyltransf_1","identifier":"PF00583"}],"pathways":[],"gene_sequence":"ATGAAAAAGACCCCAGACCCATCTCCACCTTTTGCAAGCACGAAGAACGTAGGCATGTCAAACGAAGAACCGGAAAAAATGGTTAACGATCGAATTGTGGTGAAGGCCATCGAGCCAAAAGATGAGGAAGCCTGGAACAAACTGTGGAAGGAGTATCAGGGTTTCCAAAAAACGGTTATGCCTCCGGAAGTAGCCACCACTACCTTCGCAAGGTTTATAGACCCTACGGTCAAACTATGGGGTGCTCTAGCCTTTGACACCGAGACCGGCGATGCAATTGGCTTTGCACACTACCTGAACCATTTGACGTCGTGGCATGTCGAAGAAGTTGTCTACATGAATGACTTATATGTCACTGAACGCGCAAGAGTCAAAGGCGTAGGTAGAAAGCTCATAGAATTTGTATACAGCCGTGCCGATGAGCTCGGTACGCCTGCAGTGTACTGGGTTACAGACCATTACAATCACCGCGCACAGTTGCTGTACACCAAAGTGGCTTACAAGACAGATAAGGTTCTTTACAAGAGAAACGGATACTGA","protein_sequence":"MKKTPDPSPPFASTKNVGMSNEEPEKMVNDRIVVKAIEPKDEEAWNKLWKEYQGFQKTVMPPEVATTTFARFIDPTVKLWGALAFDTETGDAIGFAHYLNHLTSWHVEEVVYMNDLYVTERARVKGVGRKLIEFVYSRADELGTPAVYWVTDHYNHRAQLLYTKVAYKTDKVLYKRNGY"}]}