{"ymdb_id":"YMDB00848","created_at":"2011-05-29T18:58:03.000Z","updated_at":"2016-09-08T18:35:58.000Z","name":"(6R)-5,10-methylenetetrahydrofolic acid","cas":"3432-99-3","state":null,"melting_point":null,"description":"(6R)-5,10-Methylenetetrahydrofolic acid is an intermediate in the metabolism of methane and the metabolism of nitrogen.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":"1989","hmdb_id":null,"kegg_id":"C00143","pubchem_id":"439175","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":"METHYLENE-THF","iupac":"(2S)-2-({4-[(6aR)-3-amino-1-oxo-1H,2H,5H,6H,6aH,7H,8H,9H-imidazolidino[1,5-f]pteridin-8-yl]phenyl}formamido)pentanedioic acid","traditional_iupac":"5,10-Methylene-THF","logp":"-2.019855468407738","pka":"3.7382996772475683","alogps_solubility":"8.23e-01 g/l","alogps_logp":"-0.94","alogps_logs":"-2.75","acceptor_count":"11","donor_count":"6","rotatable_bond_count":"7","polar_surface_area":"189.69","refractivity":"123.9566","polarizability":"45.75831886073985","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"4.596941286239965","pka_strongest_acidic":"2.9303065927026704","bioavailability":"0","number_of_rings":"4","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["(6R)-5,10-Methylenetetrahydrofolate","5,10-methylene-5,6,7,8-tetrahydrofolate","5,10-Methylene-THF","5,10-Methylenetetrahydrofolate","5,10-methylenetetrahydrofolic acid","n5,n10-methylene-5,6,7,8-tetrahydrofolate","n5,n10-methylene-tetrahydrofolate"],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null},{"name":"One Carbon Pool by Folate I","kegg_map_id":null},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":7036682,"citation":"Schirch, L. (1982). \"Serine hydroxymethyltransferase.\" Adv Enzymol Relat Areas Mol Biol 53:83-112."},{"pubmed_id":10762066,"citation":"Rao, N. A., Talwar, R., Savithri, H. S. (2000). \"Molecular organization, catalytic mechanism and function of serine hydroxymethyltransferase--a potential target for cancer chemotherapy.\" Int J Biochem Cell Biol 32:405-416."}],"proteins":[{"created_at":"2011-05-24T20:05:57.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Serine hydroxymethyltransferase, cytosolic","uniprot_id":"P37291","uniprot_name":"GLYC_YEAST","enzyme":true,"transporter":false,"gene_name":"SHM2","num_residues":469,"molecular_weight":"52218.0","theoretical_pi":"7.47","general_function":"Involved in catalytic activity","specific_function":"Interconversion of serine and glycine","reactions":[{"id":1597,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2298,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.","export":false,"pw_reaction_id":null,"source":null},{"id":3844,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006367","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"L22529","genbank_protein_id":"439120","gene_card_id":"SHM2","chromosome_location":"chromosome 12","locus":"YLR058C","synonyms":["SHMT","Glycine hydroxymethyltransferase","Serine methylase"],"enzyme_classes":["2.1.2.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" serine family amino acid metabolic process"},{"category":"Process","description":" glycine metabolic process"},{"category":"Process","description":" L-serine metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"SHMT","identifier":"PF00464"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cyanoamino acid metabolism","kegg_map_id":"00460"},{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"gene_sequence":"ATGCCTTACACTCTATCCGACGCTCATCATAAGTTGATCACCTCTCATTTGGTGGACACCGACCCTGAAGTGGACTCCATTATCAAGGATGAAATTGAAAGACAAAAGCACTCCATCGATTTGATTGCTTCTGAAAATTTCACCTCAACCTCCGTTTTCGATGCCCTTGGAACTCCATTGTCCAACAAATATTCTGAAGGTTATCCAGGTGCTCGTTACTACGGTGGTAATGAACACATTGACAGAATGGAAATTCTATGTCAACAAAGAGCTTTGAAAGCTTTCCATGTTACTCCAGACAAATGGGGTGTTAACGTCCAAACTTTATCTGGTTCTCCTGCTAACTTGCAAGTTTATCAAGCTATTATGAAGCCTCATGAAAGATTGATGGGTCTATACCTACCAGATGGTGGTCATTTGTCTCACGGTTACGCTACTGAAAACAGAAAAATTTCTGCTGTTTCCACATACTTTGAATCTTTCCCATACAGAGTTAACCCAGAAACCGGTATTATCGACTACGATACTTTAGAAAAGAACGCCATCCTATATAGACCAAAGGTTCTTGTTGCTGGTACTTCAGCATACTGTCGTTTAATTGACTACAAGAGAATGAGAGAAATCGCCGACAAATGTGGTGCTTACTTGATGGTAGACATGGCCCACATTTCTGGTTTGATCGCCGCAGGTGTCATCCCATCTCCTTTCGAATACGCTGATATCGTTACCACCACCACTCACAAGTCTTTGAGAGGTCCACGTGGTGCTATGATTTTCTTCAGAAGAGGTGTGAGATCTATCAACCCTAAGACCGGTAAGGAAGTTCTATACGACTTGGAAAACCCAATTAACTTCTCTGTTTTCCCAGGTCACCAAGGTGGTCCACACAACCATACCATTGCTGCTTTGGCCACTGCTTTGAAGCAAGCTGCCACTCCAGAATTCAAGGAATACCAAACTCAAGTCTTGAAGAATGCTAAGGCTTTGGAAAGTGAATTTAAGAACTTGGGCTACAGATTAGTTTCCAACGGTACCGATTCTCACATGGTTCTAGTATCCTTGAGAGAAAAGGGTGTTGATGGTGCTCGTGTTGAATACATTTGTGAAAAGATTAACATTGCTTTGAACAAAAATTCTATTCCAGGTGACAAATCTGCTTTGGTTCCAGGTGGTGTCCGTATTGGGGCTCCAGCCATGACCACTAGAGGAATGGGTGAAGAAGATTTCCACAGAATTGTTCAATACATTAACAAGGCTGTAGAATTCGCTCAACAAGTTCAACAAAAGCTTCCAAAGGATGCTTGTAGATTAAAGGACTTCAAAGCCAAGGTCGACGAAGGCTCTGATGTTTTGAACACCTGGAAAAAGGAAATTTACGACTGGGCTGGCGAATACCCATTGGCTGTGTAA","protein_sequence":"MPYTLSDAHHKLITSHLVDTDPEVDSIIKDEIERQKHSIDLIASENFTSTSVFDALGTPLSNKYSEGYPGARYYGGNEHIDRMEILCQQRALKAFHVTPDKWGVNVQTLSGSPANLQVYQAIMKPHERLMGLYLPDGGHLSHGYATENRKISAVSTYFESFPYRVNPETGIIDYDTLEKNAILYRPKVLVAGTSAYCRLIDYKRMREIADKCGAYLMVDMAHISGLIAAGVIPSPFEYADIVTTTTHKSLRGPRGAMIFFRRGVRSINPKTGKEVLYDLENPINFSVFPGHQGGPHNHTIAALATALKQAATPEFKEYQTQVLKNAKALESEFKNLGYRLVSNGTDSHMVLVSLREKGVDGARVEYICEKINIALNKNSIPGDKSALVPGGVRIGAPAMTTRGMGEEDFHRIVQYINKAVEFAQQVQQSLPKDACRLKDFKAKVDEGSDVLNTWKKEIYDWAGEYPLAV"},{"created_at":"2011-05-24T20:07:56.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Serine hydroxymethyltransferase, mitochondrial","uniprot_id":"P37292","uniprot_name":"GLYM_YEAST","enzyme":true,"transporter":false,"gene_name":"SHM1","num_residues":490,"molecular_weight":"53686.0","theoretical_pi":"9.05","general_function":"Involved in catalytic activity","specific_function":"Interconversion of serine and glycine","reactions":[{"id":1597,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2298,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.","export":false,"pw_reaction_id":null,"source":null},{"id":3845,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006368","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"L22528","genbank_protein_id":"408368","gene_card_id":"SHM1","chromosome_location":"chromosome 2","locus":"YBR263W","synonyms":["SHMT","Glycine hydroxymethyltransferase","Serine methylase"],"enzyme_classes":["2.1.2.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" serine family amino acid metabolic process"},{"category":"Process","description":" glycine metabolic process"},{"category":"Process","description":" L-serine metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"SHMT","identifier":"PF00464"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cyanoamino acid metabolism","kegg_map_id":"00460"},{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTTCCCAGAGCTTCTGCATTGGCCAAATGTATGGCAACTGTTCATCGTCGTGGGCTACTCACCAGTGGTGCACAATCGCTAGTCTCCAAACCAGTCTCGGAGGGAGATCCAGAGATGTTTGACATCTTGCAACAAGAACGTCACAGACAAAAACACTCTATCACCCTTATCCCATCAGAAAACTTCACCTCGAAGGCCGTTATGGATTTGTCAGGTTCTGAGCTCCAAAACAAGTATTCTGAAGGTTATCCAGGTGAAAGATACTACGGAGGTAACGAAATCATCGATAAGTCCGAATCCTTGTGTCAAGCAAGAGCTCTGGAACTGTACGGATTAGACCCTGCCAAGTGGGGAGTTAATGTTCAACCATTAAGCGGGGCACCTGCCAATTTGTATGTTTACTCCGCTATCATGAACGTTGGTGAAAGATTAATGGGATTGGATTTGCCAGATGGTGGTCACTTGTCTCACGGGTACCAACTTAAGTCAGGAACGCCAATTTCTTTCATTTCCAAATACTTCCAAAGTATGCCATACCATGTCGACCACACTACGGGGCTAATCGATTACGATAACTTGCAAGTATTGGCCAAGGCATTCAGACCAAAGGTGATCGTGGCCGGTACTTCCGCGTACTCGAGATTAATAGACTACGCTAGATTCAAGGAAATTTCCCAAGGATGCGGCGCATATTTGATGAGTGATATGGCACACATATCCGGTTTGGTGGCAGCCAATGTTGTCCCATCTCCATTTGAACATTCCGATATAGTTACCACAACCACTCACAAGTCCTTGAGAGGCCCAAGAGGTGCTATGATTTTCTTCAGAAAGGGTATCAAGTCTGTCACCAAAAAGGGCAAGGAAATCCCATATGAGTTAGAAAAGAAAATCAACTTCTCAGTTTTCCCAGGACATCAAGGTGGTCCTCACAACCATACTATCGGTGCAATGGCAGTGGCATTAAAGCAAGCGATGTCTCCAGAATTCAAAGAATACCAACAAAAAATTGTCGACAACAGCAAATGGTTTGCTCAGGAACTAACCAAGATGGGTTATAAGTTGGTTTCCGGCGGTACCGATAACCACTTGATTGTTATTGACTTATCCGGTACTCAGGTAGACGGTGCTCGTGTCGAGACAATTTTAAGTGCCTTGAACATTGCTGCTAACAAGAACACCATCCCAGGTGATAAGAGTGCTCTTTTCCCCTCTGGTCTAAGAATCGGTACTCCAGCAATGACCACGAGAGGATTTGGCCGTGAAGAGTTTTCTCAAGTCGCAAAGTACATTGATTCTGCCGTTAAGCTCGCTGAAAATTTGAAAACTTTGGAACCAACAACGAAACTAGATGCAAGATCAAGACTCAATGAGTTCAAGAAGTTGTGTAATGAATCTAGTGAAGTCGCTGCTTTGTCTGGCGAGATTTCCAAGTGGGTCGGTCAATACCCTGTCCCAGGTGATATCTAA","protein_sequence":"MFPRASALAKCMATVHRRGLLTSGAQSLVSKPVSEGDPEMFDILQQERHRQKHSITLIPSENFTSKAVMDLLGSELQNKYSEGYPGERYYGGNEIIDKSESLCQARALELYGLDPAKWGVNVQPLSGAPANLYVYSAIMNVGERLMGLDLPDGGHLSHGYQLKSGTPISFISKYFQSMPYHVDHTTGLIDYDNLQVLAKAFRPKVIVAGTSAYSRLIDYARFKEISQGCGAYLMSDMAHISGLVAANVVPSPFEHSDIVTTTTHKSLRGPRGAMIFFRKGIKSVTKKGKEIPYELEKKINFSVFPGHQGGPHNHTIGAMAVALKQAMSPEFKEYQQKIVDNSKWFAQELTKMGYKLVSGGTDNHLIVIDLSGTQVDGARVETILSALNIAANKNTIPGDKSALFPSGLRIGTPAMTTRGFGREEFSQVAKYIDSAVKLAENLKTLEPTTKLDARSRLNEFKKLCNESSEVAALSGEISKWVGQYPVPGDI"},{"created_at":"2011-05-24T20:14:31.000Z","updated_at":"2011-05-27T14:56:00.000Z","name":"Dihydrolipoyl dehydrogenase, mitochondrial","uniprot_id":"P09624","uniprot_name":"DLDH_YEAST","enzyme":true,"transporter":false,"gene_name":"LPD1","num_residues":499,"molecular_weight":"54009.69922","theoretical_pi":"8.22","general_function":"Involved in oxidoreductase activity","specific_function":"Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine","reactions":[{"id":2306,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1V59","cellular_location":"Mitochondrion matrix","genbank_gene_id":"D50617","genbank_protein_id":"836736","gene_card_id":"LPD1","chromosome_location":"chromosome 6","locus":"YFL018C","synonyms":["Dihydrolipoamide dehydrogenase","Glycine decarboxylase complex subunit L","Lipoamide dehydrogenase component of pyruvate dehydrogenase complex","Pyruvate dehydrogenase complex E3 component"],"enzyme_classes":["1.8.1.4"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on NADH or NADPH"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" dihydrolipoyl dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cell redox homeostasis"}],"pfams":[{"name":"Pyr_redox","identifier":"PF00070"},{"name":"Pyr_redox_2","identifier":"PF07992"},{"name":"Pyr_redox_dim","identifier":"PF02852"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"}],"gene_sequence":"ATGTTAAGAATCAGATCACTCCTAAATAATAAGCGTGCCTTTTCGTCCACAGTCAGGACATTGACCATTAACAAGTCACATGATGTAGTCATCATCGGTGGTGGCCCTGCTGGTTACGTGGCTGCTATCAAAGCTGCTCAATTGGGATTTAACACTGCATGTGTAGAAAAAAGAGGCAAATTAGGCGGTACCTGTCTTAACGTTGGATGTATCCCCTCCAAAGCACTTCTAAATAATTCTCATTTATTCCACCAAATGCATACGGAAGCGCAAAAGAGAGGTATTGACGTCAACGGTGATATCAAAATTAACGTAGCAAACTTCCAAAAGGCTAAGGATGACGCTGTTAAGCAATTAACTGGAGGTATTGAGCTTCTGTTCAAGAAAAATAAGGTCACCTATTATAAAGGTAATGGTTCATTCGAAGACGAAACGAAGATCAGAGTAACTCCCGTTGATGGGTTGGAAGGCACTGTCAAGGAAGACCACATACTAGATGTTAAGAACATCATAGTCGCCACGGGCTCTGAAGTTACACCCTTCCCCGGTATTGAAATAGATGAGGAAAAAATTGTCTCTTCAACAGGTGCTCTTTCGTTAAAGGAAATTCCCAAAAGATTAACCATCATTGGTGGAGGAATCATCGGATTGGAAATGGGTTCAGTTTACTCTAGATTAGGCTCCAAGGTTACTGTAGTAGAATTTCAACCTCAAATTGGTGCATCTATGGACGGCGAGGTTGCCAAAGCCACCCAAAAGTTCTTGAAAAAGCAAGGTTTGGACTTCAAATTAAGCACCAAAGTTATTTCTGCAAAGAGAAACGACGACAAGAACGTCGTCGAAATTGTTGTAGAAGATACTAAAACGAATAAGCAAGAAAATTTGGAAGCTGAAGTTTTGCTGGTTGCTGTTGGTAGAAGACCTTACATTGCTGGCTTAGGGGCTGAAAAGATTGGATTAGAAGTAGACAAAAGGGGACGCCTAGTCATTGATGACCAATTTAATTCCAAGTTCCCACACATTAAAGTGGTAGGAGATGTTACATTTGGTCCAATGCTGGCTCACAAAGCCGAAGAGGAAGGTATTGCAGCTGTCGAAATGTTGAAAACTGGTCACGGTCATGTCAACTATAACAACATTCCTTCGGTCATGTATTCTCACCCAGAAGTAGCATGGGTTGGTAAAACCGAAGAGCAATTGAAAGAAGCCGGCATTGACTATAAAATTGGTAAGTTCCCCTTTGCGGCCAATTCAAGAGCCAAGACCAACCAAGACACTGAAGGTTTCGTGAAGATTTTGATCGATTCCAAGACCGAGCGTATTTTGGGGGCTCACATTATCGGTCCAAATGCCGGTGAAATGATTGCTGAAGCTGGCTTAGCCTTAGAATATGGCGCTTCCGCAGAAGATGTTGCTAGGGTCTGCCATGCTCATCCTACTTTGTCCGAAGCATTTAAGGAAGCTAACATGGCTGCCTATGATAAAGCTATTCATTGTTGA","protein_sequence":"MLRIRSLLNNKRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC"},{"created_at":"2011-05-26T17:50:40.000Z","updated_at":"2011-05-26T17:50:40.000Z","name":"Thymidylate synthase","uniprot_id":"P06785","uniprot_name":"TYSY_YEAST","enzyme":true,"transporter":false,"gene_name":"TMP1","num_residues":304,"molecular_weight":"35046.89844","theoretical_pi":"7.16","general_function":"Involved in thymidylate synthase activity","specific_function":"Required for both nuclear and mitochondrial DNA synthesis","reactions":[{"id":2013,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2487,"direction":"\u003e","locations":null,"altext":"5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.","export":false,"pw_reaction_id":null,"source":null},{"id":14234,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006678","source":"Smpdb"},{"id":14235,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006752","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"J02706","genbank_protein_id":"172990","gene_card_id":"TMP1","chromosome_location":null,"locus":"YOR074C","synonyms":["TS","TSase"],"enzyme_classes":["2.1.1.45"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" 5,10-methylenetetrahydrofolate-dependent methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" thymidylate synthase activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleotide biosynthetic process"},{"category":"Process","description":" pyrimidine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" pyrimidine deoxyribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" dTMP biosynthetic process"}],"pfams":[{"name":"Thymidylat_synt","identifier":"PF00303"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"One Carbon Pool by Folate I","kegg_map_id":null}],"gene_sequence":"ATGACTATGGACGGAAAAAACAAAGAAGAAGAGCAATATCTTGATCTATGCAAAAGAATCATTGATGAAGGTGAATTTAGGCCAGATAGAACAGGCACTGGTACGTTGAGTCTTTTTGCACCACCCCAGCTGCGTTTTAGTTTACGTGATGATACCTTCCCACTACTAACGACCAAGAAGGTTTTTACTAGAGGTATCATACTTGAACTATTGTGGTTTTTGGCCGGTGATACAGACGCTAACCTATTGTCTGAGCAAGGTGTTAAGATTTGGGACGGTAATGGATCTCGTGAATATTTAGATAAGATGGGGTTCAAAGATAGGAAAGTAGGAGATCTGGGGCCCGTTTACGGATTTCAATGGAGGCATTTTGGTGCTAAATACAAGACGTGCGATGACGACTATACTGGACAAGGTATTGATCAATTGAAACAGGTTATACATAAACTAAAGACAAATCCCTACGATAGAAGAATCATTATGAGTGCCTGGAACCCAGCTGATTTTGACAAAATGGCTTTGCCGCCATGCCATATTTTTTCACAGTTCTATGTCAGTTTCCCCAAAGAAGGAGAAGGATCCGGTAAGCCCCGCCTTTCATGCTTATTGTACCAACGTTCTTGTGATATGGGGTTGGGAGTACCATTTAACATTGCATCATATGCTTTGTTGACTAGAATGATTGCTAAAGTTGTCGACATGGAGCCAGGTGAGTTCATTCATACTTTGGGGGATGCACATGTTTATAAAGACCACATTGATGCCTTGAAAGAACAAATCACCAGAAATCCAAGACCATTCCCGAAACTAAAGATTAAAAGGGACGTTAAAGACATTGATGATTTCAAGTTGACAGACTTTGAAATTGAAGATTATAATCCTCATCCAAGAATTCAAATGAAAATGAGTGTATAA","protein_sequence":"MTMDGKNKEEEQYLDLCKRIIDEGEFRPDRTGTGTLSLFAPPQLRFSLRDDTFPLLTTKKVFTRGIILELLWFLAGDTDANLLSEQGVKIWDGNGSREYLDKMGFKDRKVGDLGPVYGFQWRHFGAKYKTCDDDYTGQGIDQLKQVIHKLKTNPYDRRIIMSAWNPADFDKMALPPCHIFSQFYVSFPKEGEGSGKPRLSCLLYQRSCDMGLGVPFNIASYALLTRMIAKVVDMEPGEFIHTLGDAHVYKDHIDALKEQITRNPRPFPKLKIKRDVKDIDDFKLTDFEIEDYNPHPRIQMKMSV"},{"created_at":"2011-05-26T17:51:31.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"C-1-tetrahydrofolate synthase, mitochondrial","uniprot_id":"P09440","uniprot_name":"C1TM_YEAST","enzyme":true,"transporter":false,"gene_name":"MIS1","num_residues":975,"molecular_weight":"106216.0","theoretical_pi":"9.02","general_function":"Involved in formate-tetrahydrofolate ligase activity","specific_function":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH","reactions":[{"id":1548,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1727,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1733,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2488,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2489,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":2490,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":3849,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006370","source":"Smpdb"},{"id":3850,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006371","source":"Smpdb"},{"id":3851,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006372","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"J03724","genbank_protein_id":"171953","gene_card_id":"MIS1","chromosome_location":"chromosome 2","locus":"YBR084W","synonyms":["C1-THF synthase","Methylenetetrahydrofolate dehydrogenase","Methenyltetrahydrofolate cyclohydrolase","Formyltetrahydrofolate synthetase"],"enzyme_classes":["1.5.1.5","3.5.4.9","6.3.4.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" formate-tetrahydrofolate ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FTHFS","identifier":"PF01268"},{"name":"THF_DHG_CYH","identifier":"PF00763"},{"name":"THF_DHG_CYH_C","identifier":"PF02882"}],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTTGTCGAGACTATCTTTATTGAGTAACTCGAGGGCGTTCCAACAGGCCAGATGGCGCATTTACCGCTTAAAAGTTTCGCCAACTGTGCATGCTTCTCAATACCATATTCTTTCTGGTAGGAAACTTGCTCAATCTATTCGAGAAAAAGCCAATGATGAGATACAAGCCATTAAGCTTAAGCATCCTAATTTCAAGCCTACCTTGAAAATCATTCAAGTCGGGGCCAGACCAGACTCATCTACGTACGTGAGGATGAAATTGAAAGCTTCAAAGGACAGCAATGTAGACTGTATCATAGAGAAGTTACCAGCAGAAATCACTGAAGTTGAGCTTTTGAAGAAAATTAGTGACATCAATGATGATGACTCTATCCATGGGTTGCTAATTCAACTACCTCTACCGCGTCACTTGGATGAAACCACGATTACAAACGCTGTGGACTTTAAAAAGGACGTTGATGGGTTCCACAGATATAATGCTGGTGAATTGGCTAAAAAAGGAGGGAAACCATACTTCATACCATGTACTCCTTATGGTTGCATGAAATTACTTGAAGAAGCTCATGTTAAGTTAGATGGTAAGAACGCCGTCGTGTTAGGCAGATCAAGTATCGTCGGAAATCCAATTGCTTCGTTGTTGAAAAATGCGAATGCCACTGTTACTGTCTGTCATAGTCATACAAGGAACATTGCAGAAGTGGTCTCCCAAGCTGATATAGTTATCGCAGCTTGCGGTATTCCTCAATACGTTAAATCAGACTGGATTAAAGAAGGCGCCGTGGTTATTGATGTAGGTATCAACTACGTACCTGATATCAGTAAGAAAAGTGGGCAAAAATTAGTTGGTGATGTTGATTTTGATTCTGTAAAGGAAAAGACATCTTATATTACCCCTGTTCCTGGTGGAGTGGGTCCAATGACTGTCGCTATGCTTGTTTCCAATGTACTATTAGCTGCTAAAAGGCAATTCGTGGAATCTGAAAAGCTTCCAGTTATCAAACCTCTTCCATTACACTTAGAAAGTCCAGTGCCTTCAGATATTGATATATCAAGAGCTCAGAGTCCTAAGCATATCAAGCAAGTTGCCGAGGAGTTGGGAATCCACTCTCACGAATTAGAATTATACGGCCACTATAAGGCAAAAATTTCTCCAAATATTTTTAAAAGATTAGAATCTAGAGAAAACGGTAAGTACGTCCTTGTTGCAGGTATTACTCCGACTCCATTGGGTGAAGGTAAATCCACTACGACTATGGGGTTGGTGCAGGCTTTATCCGCTCATTTAGGGAAACCATCCATCGCGAACGTTAGACAACCATCTCTTGGCCCAACCCTGGGTGTCAAAGGTGGTGCTGCTGGTGGTGGTTATGCCCAAGTTATTCCTATGGACGAGTTCAATTTACATTTGACCGGGGATATTCATGCTATCAGCGCTGCGAACAATCTTCTTGCAGCAGCTATCGACACTAGAATGTTCCATGAAGCCACTCAGAAGAATGATAGTACATTTTACAAGAGACTAGTTCCAAGAAAAAAAGGCATCAGAAAGTTTACCCCATCCATGCAGAGAAGGCTTAAAAGATTGGATATTGAAAAAGAAGACCCTGATGCTTTAACACCTGAAGAAGTCAAAAGATTTGCTAGATTGAACATAAATCCCGATACTATCACTATCAGAAGAGTTGTCGACATCAATGACAGGATGTTAAGACAAATTACCATTGGCGAAGCCGCTACGGAGAAGGGTTTTACAAGGACCACTGGATTCGATATCACTGTTGCCTCTGAATTAATGGCCATTTTAGCTCTATCTAAAAGCTTACACGAGATGAAGGAACGTATTGGACGCATGGTTATTGGTGCTGATTATGATAACAAACCAGTAACAGTAGAAGATATTGGCTGTACCGGTGCTCTGACTGCATTATTACGTGACGCTATAAAGCCTAACTTAATGCAAACTTTGGAAGGGACCCCCGTAATGGTTCACGCTGGTCCTTTCGCCAACATCTCCATCGGCGCATCATCAGTAATTGCAGACTTAATGGCATTGAAGCTTGTTGGTTCAGAAAAGAACCCGTTAAATGACAAGAACATCCATGAACCTGGTTATGTAGTTACTGAAGCAGGATTCGATTTTGCCATGGGTGGTGAAAGATTCTTTGATATCAAATGTCGTTCCTCTGGATTGGTGCCAGATGCAGTTGTCTTAGTCGCAACCGTAAGAGCTTTGAAATCTCATGGAGGTGCTCCAAATGTTAAGCCCGGACAATCATTACCAAAAGAATACACAGAGGAAAACATCGATTTTGTTGCCAAGGGTGTTAGTAATTTGGTTAAGCAGATTGAAAACATCAAAACGTTTGGAATACCAGTCGTTGTAGCAATCAACAGATTTGAAACAGACTCACAGGCAGAGATTGAGGTAATCAAGAAAGCAGCCTTGAATGCTGGCGCATCTCATGCCGTTACTTCTAATCACTGGATGGAAGGTGGTAAAGGTGCAGTAGAATTAGCACATGCTGTGGTAGATGCAACGAAAGAACCAAAGAACTTTAACTTTTTGTACGACGTCAATAGCTCCATCGAGGACAAGCTTACCAGCATCGTCCAAAAAATGTATGGTGGGGCAAAAATCGAAGTATCACCAGAAGCCCAAAAAAAGATAGACACCTACAAAAAACAAGGCTTCGGTAATCTTCCCATCTGTATTGCTAAGACACAATATTCATTATCCCATGATCCATCATTAAAGGGTGTTCCTAGAGGTTTTACGTTCCCCATCAGGGATGTGAGAGCTTCAATAGGTGCAGGTTATTTATACGCTTTGGCTGCAGAAATTCAAACCATACCGGGTCTATCGACATATGCTGGTTACATGGCAGTAGAAGTCGACGACGACGGTGAAATTGAAGGTCTATTTTAA","protein_sequence":"MLSRLSLLSNSRAFQQARWRIYRLKVSPTVHASQYHILSGRKLAQSIREKANDEIQAIKLKHPNFKPTLKIIQVGARPDSSTYVRMKLKASKDSNVDCIIEKLPAEITEVELLKKISDINDDDSIHGLLIQLPLPRHLDETTITNAVDFKKDVDGFHRYNAGELAKKGGKPYFIPCTPYGCMKLLEEAHVKLDGKNAVVLGRSSIVGNPIASLLKNANATVTVCHSHTRNIAEVVSQADIVIAACGIPQYVKSDWIKEGAVVIDVGINYVPDISKKSGQKLVGDVDFDSVKEKTSYITPVPGGVGPMTVAMLVSNVLLAAKRQFVESEKLPVIKPLPLHLESPVPSDIDISRAQSPKHIKQVAEELGIHSHELELYGHYKAKISPNIFKRLESRENGKYVLVAGITPTPLGEGKSTTTMGLVQALSAHLGKPSIANVRQPSLGPTLGVKGGAAGGGYAQVIPMDEFNLHLTGDIHAISAANNLLAAAIDTRMFHEATQKNDSTFYKRLVPRKKGIRKFTPSMQRRLKRLDIEKEDPDALTPEEVKRFARLNINPDTITIRRVVDINDRMLRQITIGEAATEKGFTRTTGFDITVASELMAILALSKSLHEMKERIGRMVIGADYDNKPVTVEDIGCTGALTALLRDAIKPNLMQTLEGTPVMVHAGPFANISIGASSVIADLMALKLVGSEKNPLNDKNIHEPGYVVTEAGFDFAMGGERFFDIKCRSSGLVPDAVVLVATVRALKSHGGAPNVKPGQSLPKEYTEENIDFVAKGVSNLVKQIENIKTFGIPVVVAINRFETDSQAEIEVIKKAALNAGASHAVTSNHWMEGGKGAVELAHAVVDATKEPKNFNFLYDVNSSIEDKLTSIVQKMYGGAKIEVSPEAQKKIDTYKKQGFGNLPICIAKTQYSLSHDPSLKGVPRGFTFPIRDVRASIGAGYLYALAAEIQTIPGLSTYAGYMAVEVDDDGEIEGLF"},{"created_at":"2011-05-26T17:53:55.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"C-1-tetrahydrofolate synthase, cytoplasmic","uniprot_id":"P07245","uniprot_name":"C1TC_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE3","num_residues":946,"molecular_weight":"102204.0","theoretical_pi":"6.83","general_function":"Involved in formate-tetrahydrofolate ligase activity","specific_function":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH","reactions":[{"id":1548,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1727,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1733,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2488,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2489,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":2490,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"AY692966","genbank_protein_id":"51013383","gene_card_id":"ADE3","chromosome_location":"chromosome 7","locus":"YGR204W","synonyms":["C1-THF synthase","Methylenetetrahydrofolate dehydrogenase","Methenyltetrahydrofolate cyclohydrolase","Formyltetrahydrofolate synthetase"],"enzyme_classes":["1.5.1.5","3.5.4.9","6.3.4.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" formate-tetrahydrofolate ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FTHFS","identifier":"PF01268"},{"name":"THF_DHG_CYH","identifier":"PF00763"},{"name":"THF_DHG_CYH_C","identifier":"PF02882"}],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"One carbon pool by folate","kegg_map_id":"00670"}],"gene_sequence":"ATGGCTGGTCAAGTGTTGGACGGCAAAGCATGCGCTCAGCAGTTTAGAAGCAATATTGCTAATGAAATCAAAAGCATTCAAGGTCACGTGCCTGGGTTTGCACCTAACCTTGCCATCATTCAAGTAGGCAACAGACCAGACTCAGCCACATATGTACGCATGAAGCGTAAGGCAGCTGAAGAGGCCGGCATTGTTGCTAATTTCATTCATTTAGATGAATCCGCTACTGAATTTGAAGTTCTGCGTTACGTGGACCAGCTGAATGAGGACCCACATACACACGGTATTATCGTGCAACTACCATTACCCGCTCATTTGGACGAGGATAGAATCACCTCGAGAGTGTTGGCAGAAAAGGACGTGGACGGGTTCGGGCCCACCAACATTGGCGAATTGAATAAGAAGAACGGACACCCATTCTTTTTGCCCTGCACGCCCAAGGGGATCATTGAGCTGCTTCACAAGGCCAACGTCACGATTGAAGGTTCCCGGTCCGTTGTGATCGGAAGATCTGACATTGTTGGCTCTCCTGTTGCAGAATTGTTAAAATCTCTAAACTCCACCGTCACCATCACTCATTCTAAAACCCGTGATATCGCATCATACTTACACGACGCGGACATCGTAGTCGTTGCCATCGGCCAACCAGAATTTGTGAAGGGTGAATGGTTCAAACCAAGAGACGGCACTTCCAGTGATAAGAAAACCGTGGTAATTGATGTTGGCACCAACTACGTTGCTGATCCTTCCAAAAAGTCCGGTTTCAAATGTGTTGGTGACGTTGAGTTCAATGAAGCAATCAAATACGTCCATCTAATCACTCCAGTGCCCGGTGGTGTGGGCCCCATGACGGTGGCTATGTTAATGCAAAATACCTTGATTGCTGCCAAACGCCAAATGGAAGAATCCTCGAAGCCTTTGCAGATTCCTCCCTTGCCATTGAAGTTGCTAACACCTGTTCCTTCCGATATAGACATCTCCAGAGCACAACAGCCAAAGCTTATCAACCAGCTTGCTCAAGAATTGGGTATTTACTCTCATGAGTTGGAGCTGTACGGACATTACAAGGCCAAAATTTCTCCTAAAGTCATCGAAAGGCTGCAGACGCGCCAAAATGGTAAGTACATCTTGGTGTCTGGTATCACACCAACACCACTGGGAGAGGGTAAATCCACTACAACAATGGGTCTTGTCCAGGCACTAACGGCTCACTTGGGCAAGCCAGCCATTGCGAACGTCAGACAACCCTCCCTAGGACCCACTTTAGGTGTCAAAGGTGGTGCTGCGGGTGGTGGTTATTCCCAAGTCATCCCAATGGACGAATTCAACTTACATTTGACTGGTGACATTCACGCCATTGGTGCGGCTAACAACCTACTTGCTGCCGCTATTGACACTAGAATGTTCCATGAGACCACTCAAAAGAACGACGCTACCTTCTACAACAGACTAGTGCCTAGAAAGAACGGAAAGAGAAAGTTTACTCCCTCCATGCAAAGAAGATTGAACAGACTGGGTATTCAAAAGACCAACCCCGATGATCTAACACCCGAAGAGATCAACAAATTCGCCAGATTGAACATTGACCCGGACACTATTACTATCAAGAGGGTGGTCGATATCAACGACAGAATGTTAAGACAAATCACCATTGGTCAAGCCCCTACCGAGAAGAACCACACAAGAGTTACTGGATTCGATATCACCGTTGCTTCTGAATTGATGGCTATTCTTGCTCTTTCAAAGGACTTGAGGGACATGAAGGAACGTATTGGAAGAGTCGTTGTTGCTGCTGACGTAAACAGGTCTCCAGTCACTGTTGAAGATGTGGGTTGTACCGGTGCCTTAACCGCTTTATTAAGAGACGCTATCAAGCCCAACTTGATGCAAACTTTAGAAGGTACTCCTGTCTTGGTCCATGCCGGCCCATTTGCCAACATCTCTATCGGTGCCTCTTCTGTTATTGCTGATCGCGTGGCTTTGAAATTGGTTGGTACCGAGCCAGAGGCAAAAACAGAAGCTGGTTATGTGGTTACTGAAGCAGGGTTCGATTTCACTATGGGTGGTGAAAGATTCTTCAACATCAAGTGCCGTTCCTCTGGATTGACACCTAATGCTGTGGTCTTGGTTGCTACTGTTAGGGCATTGAAGTCACACGGTGGTGCTCCAGATGTCAAACCTGGCCAACCTTTACCTTCCGCATACACTGAAGAGAATATCGAGTTTGTCGAAAAAGGTGCCGCTAACATGTGTAAACAAATTGCCAACATTAAGCAATTTGGCGTCCCCGTCGTTGTCGCAATTAACAAGTTTGAAACTGACACTGAAGGTGAAATAGCCGCCATTAGAAAAGCCGCTTTGGAAGCTGGTGCATTTGAAGCCGTAACCTCTAACCATTGGGCCGAAGGTGGTAAAGGTGCTATCGACTTGGCCAAGGCCGTCATCGAAGCTTCCAACCAACCAGTGGACTTCCATTTCCTATATGACGTTAACTCCTCCGTTGAAGACAAATTAACTACTATCGTTCAAAAGATGTACGGTGGTGCCGCAATCGATATCTTGCCTGAAGCACAACGCAAGATTGACATGTACAAGGAACAAGGTTTCGGTAACTTGCCAATTTGTATCGCCAAGACACAATACTCTTTATCCCACGATGCAACTTTGAAAGGTGTTCCAACCGGGTTCACTTTCCCCATCAGAGACGTCAGATTGTCTAATGGTGCTGGATACTTATACGCTCTTGCCGCCGAAATACAAACCATTCCTGGTTTGGCTACCTATGCTGGTTACATGGCCGTGGAAGTCGATGATGACGGTGAGATCGATGGCCTGTTCTAA","protein_sequence":"MAGQVLDGKACAQQFRSNIANEIKSIQGHVPGFAPNLAIIQVGNRPDSATYVRMKRKAAEEAGIVANFIHLDESATEFEVLRYVDQLNEDPHTHGIIVQLPLPAHLDEDRITSRVLAEKDVDGFGPTNIGELNKKNGHPFFLPCTPKGIIELLHKANVTIEGSRSVVIGRSDIVGSPVAELLKSLNSTVTITHSKTRDIASYLHDADIVVVAIGQPEFVKGEWFKPRDGTSSDKKTVVIDVGTNYVADPSKKSGFKCVGDVEFNEAIKYVHLITPVPGGVGPMTVAMLMQNTLIAAKRQMEESSKPLQIPPLPLKLLTPVPSDIDISRAQQPKLINQLAQELGIYSHELELYGHYKAKISPKVIERLQTRQNGKYILVSGITPTPLGEGKSTTTMGLVQALTAHLGKPAIANVRQPSLGPTLGVKGGAAGGGYSQVIPMDEFNLHLTGDIHAIGAANNLLAAAIDTRMFHETTQKNDATFYNRLVPRKNGKRKFTPSMQRRLNRLGIQKTNPDDLTPEEINKFARLNIDPDTITIKRVVDINDRMLRQITIGQAPTEKNHTRVTGFDITVASELMAILALSKDLRDMKERIGRVVVAADVNRSPVTVEDVGCTGALTALLRDAIKPNLMQTLEGTPVLVHAGPFANISIGASSVIADRVALKLVGTEPEAKTEAGYVVTEAGFDFTMGGERFFNIKCRSSGLTPNAVVLVATVRALKSHGGAPDVKPGQPLPSAYTEENIEFVEKGAANMCKQIANIKQFGVPVVVAINKFETDTEGEIAAIRKAALEAGAFEAVTSNHWAEGGKGAIDLAKAVIEASNQPVDFHFLYDVNSSVEDKLTTIVQKMYGGAAIDILPEAQRKIDMYKEQGFGNLPICIAKTQYSLSHDATLKGVPTGFTFPIRDVRLSNGAGYLYALAAEIQTIPGLATYAGYMAVEVDDDGEIDGLF"},{"created_at":"2011-05-26T18:21:30.000Z","updated_at":"2011-07-22T17:53:47.000Z","name":"3-methyl-2-oxobutanoate hydroxymethyltransferase","uniprot_id":"P38122","uniprot_name":"PANB_YEAST","enzyme":true,"transporter":false,"gene_name":"ECM31","num_residues":312,"molecular_weight":"34464.69922","theoretical_pi":"8.26","general_function":"Involved in 3-methyl-2-oxobutanoate hydroxymethyltransferase activity","specific_function":"5,10-methylenetetrahydrofolate + 3-methyl-2- oxobutanoate + H(2)O = tetrahydrofolate + 2-dehydropantoate","reactions":[{"id":1185,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2526,"direction":"\u003e","locations":null,"altext":"5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H(2)O = tetrahydrofolate + 2-dehydropantoate.","export":false,"pw_reaction_id":null,"source":null},{"id":14215,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006654","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z36045","genbank_protein_id":"536525","gene_card_id":"ECM31","chromosome_location":"chromosome 2","locus":"YBR176W","synonyms":["Extracellular matrix protein 31","Ketopantoate hydroxymethyltransferase"],"enzyme_classes":["2.1.2.11"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" hydroxymethyl-, formyl- and related transferase activity"},{"category":"Function","description":" 3-methyl-2-oxobutanoate hydroxymethyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" pantothenate biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Pantoate_transf","identifier":"PF02548"}],"pathways":[{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"}],"gene_sequence":"ATGAATATAATGAAAAGACAATTATGCACCTCCTCTAAGCGATTTTTTTCTACAGCAAAAAACGTTGTCAAATATAATACGATTCAGGATATCAGGAACAAATATTTTACTGGTACGCCTTTGTCGATGTGTACTGCGTATGACTTCATTACTGCAACATGGGTTAACAAGGCTAATTGTGATTTACTCTTAGTCGGAGATTCTTTGGCGATGACTTCATTGGGGTACGATAGCACAATTACACTATCCTTGAATGAGTTTAAATATCATGTTGCCTCTGTGTGCAGAGCTGAAGGTTCTTCCATGGTAGTGGTAGACATGCCATTCGGTACGTTTGAATCGGGCATATCTGATGGCTTGAAGAATGCCATAGATATCATGAAATTGGACAGTAAAGTCACCTCAGTCAAAGTTGAAGTCGGTTCTTACACCAAAGACAAATATGCAATGAAATTTATTGAAGAACTGTGCTCCCGGGGTATACCTGTTATGGCTCATATAGGACTAACTCCCCAAAAAGTTCATTCACTTGGAGGTTATAAAGTGCAAGGTAGCAAAAGTCTATTACAAATGCAGGAGCTGTATGAAACCGCCATGCAACTACAAAAAATTGGCTGTTGGTCTATCCTGATTGAATGTGTCCCCCATAAGATGGCTCAGTTCATAACATCTAAACTCTCAGTACCAACAATAGGTATCGGTGCAGGTAACGGTACCAGTGGACAAGTTCTAGTTATATCTGACCTTCTCGGGATGCAAGGCGATTCTGTCCCAAAATTTGTGAAGCAAGCTGTAAATATGACAGATATTGCCACTCAGGGCTTGAAGGAGTACATTGCAAGTGTAGAGGATAGGACATTTCCTGAGAGAGGTACTCATACTTTCAAAGTTAAGGAGGACTTATGGAATGAATTCCTCTCTTCAATTAACGAAAAGTAA","protein_sequence":"MNIMKRQLCTSSKRFFSTAKNVVKYNTIQDIRNKYFTGTPLSMCTAYDFITATWVNKANCDLLLVGDSLAMTSLGYDSTITLSLNEFKYHVASVCRAEGSSMVVVDMPFGTFESGISDGLKNAIDIMKLDSKVTSVKVEVGSYTKDKYAMKFIEELCSRGIPVMAHIGLTPQKVHSLGGYKVQGSKSLLQMQELYETAMQLQKIGCWSILIECVPHKMAQFITSKLSVPTIGIGAGNGTSGQVLVISDLLGMQGDSVPKFVKQAVNMTDIATQGLKEYIASVEDRTFPERGTHTFKVKEDLWNEFLSSINEK"},{"created_at":"2011-05-27T01:39:09.000Z","updated_at":"2011-05-27T15:01:15.000Z","name":"Methylenetetrahydrofolate dehydrogenase [NAD+]","uniprot_id":"Q02046","uniprot_name":"MTD1_YEAST","enzyme":true,"transporter":false,"gene_name":"MTD1","num_residues":320,"molecular_weight":"36239.30078","theoretical_pi":"7.01","general_function":"Involved in binding","specific_function":"Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis","reactions":[{"id":1732,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2634,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1EE9","cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"L02934","genbank_protein_id":"172016","gene_card_id":"MTD1","chromosome_location":"chromosome 11","locus":"YKR080W","synonyms":[],"enzyme_classes":["1.5.1.15"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"THF_DHG_CYH","identifier":"PF00763"},{"name":"THF_DHG_CYH_C","identifier":"PF02882"}],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"}],"gene_sequence":"ATGTCGAAGCCTGGTCGTACTATTTTAGCAAGCAAGGTCGCCGAAACTTTCAATACCGAAATAATTAACAACGTAGAGGAATACAAGAAGACACATAATGGTCAAGGTCCCCTTCTTGTGGGATTCCTAGCTAATAATGATCCTGCTGCAAAGATGTATGCTACATGGACTCAAAAGACTAGCGAGTCAATGGGGTTCCGCTATGACTTAAGGGTCATTGAAGATAAGGATTTTTTGGAAGAAGCGATAATACAAGCTAACGGCGATGACTCTGTGAACGGTATCATGGTATACTTTCCTGTTTTCGGTAATGCTCAAGATCAGTATTTGCAACAGGTTGTGTGCAAGGAAAAGGATGTAGAAGGGTTAAATCATGTTTACTACCAAAACCTGTACCATAATGTCAGATACCTGGACAAAGAAAACCGTTTGAAATCCATTCTACCTTGCACACCACTAGCTATCGTTAAGATATTGGAATTCTTGAAAATTTACAACAATTTGTTACCAGAAGGAAACAGACTGTATGGGAAGAAATGCATAGTAATTAACAGGTCAGAAATCGTCGGTAGACCACTGGCGGCGCTATTAGCCAATGATGGTGCCACAGTATACTCTGTGGACGTTAACAACATTCAAAAATTCACCCGTGGTGAAAGTTTGAAATTAAACAAGCATCATGTGGAAGACCTTGGGGAGTACTCTGAAGATCTGTTGAAAAAGTGTTCTCTTGATTCAGATGTGGTCATCACTGGTGTCCCTAGTGAAAATTACAAATTCCCCACCGAATACATCAAAGAAGGTGCCGTCTGCATCAATTTTGCATGCACCAAAAATTTTAGCGATGATGTCAAGGAAAAAGCTTCTCTTTACGTTCCAATGACTGGTAAAGTTACCATTGCAATGTTGTTGAGAAACATGTTACGTTTAGTAAGGAACGTAGAACTGTCTAAAGAAAAATAG","protein_sequence":"MSKPGRTILASKVAETFNTEIINNVEEYKKTHNGQGPLLVGFLANNDPAAKMYATWTQKTSESMGFRYDLRVIEDKDFLEEAIIQANGDDSVNGIMVYFPVFGNAQDQYLQQVVCKEKDVEGLNHVYYQNLYHNVRYLDKENRLKSILPCTPLAIVKILEFLKIYNNLLPEGNRLYGKKCIVINRSEIVGRPLAALLANDGATVYSVDVNNIQKFTRGESLKLNKHHVEDLGEYSEDLLKKCSLDSDVVITGVPSENYKFPTEYIKEGAVCINFACTKNFSDDVKEKASLYVPMTGKVTIAMLLRNMLRLVRNVELSKEK"},{"created_at":"2011-05-29T03:50:36.000Z","updated_at":"2011-07-22T17:53:50.000Z","name":"Methylenetetrahydrofolate reductase 2","uniprot_id":"P53128","uniprot_name":"MTHR2_YEAST","enzyme":true,"transporter":false,"gene_name":"MET13","num_residues":600,"molecular_weight":"68559.5","theoretical_pi":"5.58","general_function":"Involved in methylenetetrahydrofolate reductase (NADPH) activity","specific_function":"5-methyltetrahydrofolate + NAD(P)(+) = 5,10- methylenetetrahydrofolate + NAD(P)H","reactions":[{"id":1212,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2773,"direction":"\u003e","locations":"","altext":"5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"MET13","chromosome_location":"chromosome 7","locus":"YGL125W","synonyms":["YmL45"],"enzyme_classes":["1.5.1.20"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" methylenetetrahydrofolate reductase (NADPH) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" sulfur amino acid metabolic process"},{"category":"Process","description":" methionine metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"MTHFR","identifier":"PF02219"}],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"gene_sequence":"ATGAAGATCACAGAAAAATTAGAGCAACATAGACAGACCTCTGGCAAGCCCACTTACTCATTCGAGTACTTCGTCCCGAAGACTACACAAGGTGTACAGAACCTGTATGACCGGATGGACCGGATGTACGAGGCTTCTTTGCCCCAATTTATTGACATCACCTGGAATGCAGGCGGTGGACGGTTGTCACATCTGTCCACGGACTTGGTTGCGACAGCGCAGTCTGTGCTTGGTTTGGAAACGTGCATGCACCTTACCTGCACCAATATGCCCATTTCGATGATTGACGACGCTTTAGAAAACGCTTATCACTCCGGTTGCCAGAACATCCTAGCGCTGAGAGGAGATCCTCCTAGGGACGCAGAAAACTGGACTCCCGTTGAAGGTGGCTTCCAGTATGCCAAGGACTTGATTAAGTATATCAAGTCCAAGTACGGTGACCATTTCGCTATCGGCGTTGCCGGCTACCCGGAGTGCCATCCGGAGTTGCCTAACAAAGACGTGAAGCTTGATCTCGAGTATTTGAAGCAGAAGATCGACGCCGGCGGCGACTTCATCATCACTCAGATGTTTTACGATGTTGATAATTTCATCAACTGGTGTTCCCAAGTTAGAGCTGCGGGCATGGACGTGCCCATTATTCCCGGGATCATGCCGATCACTACCTACGCGGCCTTCTTGAGAAGGGCCCAATGGGGCCAAATCTCCATCCCTCAACATTTCTCGTCCCGATTGGATCCTATCAAGGACGATGACGAGTTGGTCCGTGATATCGGAACTAACTTGATCGTGGAAATGTGTCAAAAATTGCTCGACAGTGGTTACGTTTCTCACTTGCACATCTACACCATGAACTTGGAAAAAGCGCCTCTCATGATTCTGGAAAGATTGAACATTCTACCTACGGAATCAGAGTTCAATGCACATCCATTGGCCGTGTTGCCATGGAGAAAATCTTTGAATCCAAAGCGTAAAAACGAGGAAGTCAGACCTATCTTCTGGAAGAGAAGACCTTACTCCTATGTCGCAAGAACCTCTCAATGGGCCGTGGACGAATTCCCCAACGGTAGATTCGGTGATTCGTCTTCTCCTGCGTTCGGTGACTTGGATCTGTGTGGTTCAGACTTGATCAGGCAATCAGCGAACAAATGTCTCGAATTATGGTCCACCCCTACTTCCATCAACGACGTCGCCTTCTTGGTCATCAACTACTTGAATGGAAACTTGAAGTGTTTACCTTGGAGTGATATCCCCATCAATGATGAAATAAATCCAATCAAAGCACACTTGATTGAGCTGAACCAGCATTCTATCATCACTATAAACTCTCAACCTCAAGTCAACGGCATTAGGTCCAATGACAAAATTCATGGTTGGGGACCCAAGGATGGTTACGTTTACCAGAAGCAATATTTGGAATTTATGTTGCCCAAGACTAAGTTGCCCAAGTTGATTGACACCTTGAAAAACAATGAGTTCTTGACCTACTTCGCCATCGACTCTCAAGGTGACCTGCTAAGTAATCATCCAGACAACTCCAAGTCCAACGCTGTGACTTGGGGTATTTTCCCCGGCAGAGAAATTCTTCAACCTACCATTGTCGAGAAAATTTCGTTCTTAGCGTGGAAGGAGGAGTTCTATCATATCTTGAATGAATGGAAACTAAACATGAATAAATACGATAAACCGCATAGTGCCCAATTCATTCAGTCCTTGATTGACGATTACTGCTTGGTCAATATTGTTGACAATGACTACATTTCTCCAGATGATCAAATCCATTCCATCCTACTAAGCCTATAA","protein_sequence":"MKITEKLEQHRQTSGKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGGGRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPRDAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPNKDVKLDLEYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQWGQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLMILERLNILPTESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAVDEFPNGRFGDSSSPAFGDLDLCGSDLIRQSANKCLELWSTPTSINDVAFLVINYLNGNLKCLPWSDIPINDEINPIKAHLIELNQHSIITINSQPQVNGIRSNDKIHGWGPKDGYVYQKQYLEFMLPKTKLPKLIDTLKNNEFLTYFAIDSQGDLLSNHPDNSKSNAVTWGIFPGREILQPTIVEKISFLAWKEEFYHILNEWKLNMNKYDKPHSAQFIQSLIDDYCLVNIVDNDYISPDDQIHSILLSL"}]}