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Adenosine triphosphate (YMDB00109)
| Identification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| YMDB ID | YMDB00109 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Name | Adenosine triphosphate | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Saccharomyces cerevisiae | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strain | Baker's yeast | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | Adenosine triphosphate (ATP) is an adenine nucleotide. ATP occurs in all known life forms as a high-energy intermediate which transports chemical energy within cells for metabolism. It is produced by photophosphorylation and cellular respiration. It is used as a substrate in signal transduction pathways, by kinases that phosphorylate proteins and lipids, and by adenylate cyclase which uses ATP to produce the second messenger molecule cyclic AMP. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Structure |  | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms |
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| CAS number | 56-65-5 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Weight | Average: 507.181 Monoisotopic: 506.995745159 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InChI Key | ZKHQWZAMYRWXGA-KQYNXXCUSA-N | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InChI | InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IUPAC Name | ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Traditional IUPAC Name | adenosine triphosphate | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical Formula | C10H16N5O13P3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SMILES | [H]O[C@]1([H])[C@]([H])(O[H])[C@]([H])(O[C@@]1([H])N1C([H])=NC2=C1N=C([H])N=C2N([H])[H])C([H])([H])OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O[H] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical Taxonomy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | belongs to the class of organic compounds known as purine ribonucleoside triphosphates. These are purine ribobucleotides with a triphosphate group linked to the ribose moiety. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kingdom | Organic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Super Class | Nucleosides, nucleotides, and analogues | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Class | Purine nucleotides | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sub Class | Purine ribonucleotides | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Direct Parent | Purine ribonucleoside triphosphates | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Alternative Parents |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Substituents |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Framework | Aromatic heteropolycyclic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| External Descriptors |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Physical Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| State | Solid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Charge | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Melting point | 187 °C | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Predicted Properties |
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| Biological Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cellular Locations |
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| Organoleptic Properties | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SMPDB Pathways |
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| KEGG Pathways |
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| SMPDB Reactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KEGG Reactions |
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| Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Intracellular Concentrations |
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| Extracellular Concentrations | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spectra |
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| References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| References: |
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| Synthesis Reference: | Clark, V. M.; Kirby, G. W.; Todd, Alexander. Phosphorylation. XV. Use of phosphoramidic esters in acylation-new preparation of adenosine 5'-pyrophosphate and adenosine 5'-triphosphate. Journal of the Chemical Society (1957), 1497-1501. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Enzymes
- General function:
- Involved in adenosine kinase activity
- Specific function:
- ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. ADO1 does not play a major role in adenine utilization in yeast. Its physiological role could primarily be to recycle adenosine produced by the methyl cycle
- Gene Name:
- ADO1
- Uniprot ID:
- P47143
- Molecular weight:
- 36372.0
Reactions
| ATP + adenosine → ADP + AMP. |
- General function:
- Involved in catalytic activity
- Specific function:
- ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate
- Gene Name:
- ADE6
- Uniprot ID:
- P38972
- Molecular weight:
- 148904.0
Reactions
| ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O → ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)
- Gene Name:
- GLN4
- Uniprot ID:
- P13188
- Molecular weight:
- 93132.20313
Reactions
| ATP + L-glutamine + tRNA(Gln) → AMP + diphosphate + L-glutaminyl-tRNA(Gln). |
- General function:
- Involved in catalytic activity
- Specific function:
- 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
- Gene Name:
- CPA1
- Uniprot ID:
- P07258
- Molecular weight:
- 45361.19922
Reactions
| 2 ATP + L-glutamine + HCO(3)(-) + H(2)O → 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. |
- General function:
- Involved in carboxyl- or carbamoyltransferase activity
- Specific function:
- This protein is a "fusion" protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase)
- Gene Name:
- URA2
- Uniprot ID:
- P07259
- Molecular weight:
- 245124.0
Reactions
| 2 ATP + L-glutamine + HCO(3)(-) + H(2)O → 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. |
| Carbamoyl phosphate + L-aspartate → phosphate + N-carbamoyl-L-aspartate. |
- General function:
- Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor
- Specific function:
- Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln). Required for HMG2-induced ER-remodeling
- Gene Name:
- HER2
- Uniprot ID:
- Q03557
- Molecular weight:
- 50918.0
Reactions
| ATP + L-glutamyl-tRNA(Gln) + L-glutamine → ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. |
- General function:
- Involved in ATP binding
- Specific function:
- 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
- Gene Name:
- CPA2
- Uniprot ID:
- P03965
- Molecular weight:
- 123914.0
Reactions
| 2 ATP + L-glutamine + HCO(3)(-) + H(2)O → 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. |
- General function:
- Involved in CTP synthase activity
- Specific function:
- Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen
- Gene Name:
- URA7
- Uniprot ID:
- P28274
- Molecular weight:
- 64709.80078
Reactions
| ATP + UTP + NH(3) → ADP + phosphate + CTP. |
- General function:
- Involved in glutamate-ammonia ligase activity
- Specific function:
- ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine
- Gene Name:
- GLN1
- Uniprot ID:
- P32288
- Molecular weight:
- 41705.60156
Reactions
| ATP + L-glutamate + NH(3) → ADP + phosphate + L-glutamine. |
- General function:
- Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor
- Specific function:
- Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln)
- Gene Name:
- PET112
- Uniprot ID:
- P33893
- Molecular weight:
- 61842.19922
Reactions
| ATP + L-glutamyl-tRNA(Gln) + L-glutamine → ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. |
- General function:
- Involved in catalytic activity
- Specific function:
- ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate
- Gene Name:
- GUA1
- Uniprot ID:
- P38625
- Molecular weight:
- 58481.80078
Reactions
| ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O → AMP + diphosphate + GMP + L-glutamate. |
- General function:
- Involved in asparagine synthase (glutamine-hydrolyzing) activity
- Specific function:
- ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate
- Gene Name:
- ASN1
- Uniprot ID:
- P49089
- Molecular weight:
- 64469.60156
Reactions
| ATP + L-aspartate + L-glutamine + H(2)O → AMP + diphosphate + L-asparagine + L-glutamate. |
- General function:
- Involved in asparagine synthase (glutamine-hydrolyzing) activity
- Specific function:
- ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate
- Gene Name:
- ASN2
- Uniprot ID:
- P49090
- Molecular weight:
- 64592.5
Reactions
| ATP + L-aspartate + L-glutamine + H(2)O → AMP + diphosphate + L-asparagine + L-glutamate. |
- General function:
- Involved in CTP synthase activity
- Specific function:
- Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Plays an important role in the regulation of phospholipid synthesis
- Gene Name:
- URA8
- Uniprot ID:
- P38627
- Molecular weight:
- 63055.69922
Reactions
| ATP + UTP + NH(3) → ADP + phosphate + CTP. |
- General function:
- Involved in NAD+ synthase (glutamine-hydrolyzing) activity
- Specific function:
- ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate
- Gene Name:
- QNS1
- Uniprot ID:
- P38795
- Molecular weight:
- 80684.89844
Reactions
| ATP + deamido-NAD(+) + L-glutamine + H(2)O → AMP + diphosphate + NAD(+) + L-glutamate. |
- General function:
- Involved in ATP binding
- Specific function:
- Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln)
- Gene Name:
- Not Available
- Uniprot ID:
- P53260
- Molecular weight:
- 20786.80078
Reactions
| ATP + L-glutamyl-tRNA(Gln) + L-glutamine → ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate. |
- General function:
- Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor
- Specific function:
- Hydrolysis of urea to ammonia and CO(2)
- Gene Name:
- DUR1
- Uniprot ID:
- P32528
- Molecular weight:
- 201830.0
Reactions
| ATP + urea + HCO(3)(-) → ADP + phosphate + urea-1-carboxylate. |
| Urea-1-carboxylate + H(2)O → 2 CO(2) + 2 NH(3). |
- General function:
- Involved in galactokinase activity
- Specific function:
- ATP + D-galactose = ADP + alpha-D-galactose 1- phosphate
- Gene Name:
- GAL1
- Uniprot ID:
- P04385
- Molecular weight:
- 57943.80078
Reactions
| ATP + D-galactose → ADP + alpha-D-galactose 1-phosphate. |
- General function:
- Involved in sulfate adenylyltransferase (ATP) activity
- Specific function:
- Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur- containing amino acids
- Gene Name:
- MET3
- Uniprot ID:
- P08536
- Molecular weight:
- 57724.0
Reactions
| ATP + sulfate → diphosphate + adenylyl sulfate. |
- General function:
- Involved in ATP adenylyltransferase activity
- Specific function:
- Ap4A phosphorylase catabolizes Ap4N nucleotides (where N is A,C,G or U). Additionally this enzyme catalyzes the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulfate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP
- Gene Name:
- APA1
- Uniprot ID:
- P16550
- Molecular weight:
- 36492.19922
Reactions
| ADP + ATP → phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate. |
| ADP + sulfate → phosphate + adenylyl sulfate. |
| Adenylylsulfate + ATP → P(1),P(4)-bis(5'-adenosyl)tetraphosphate + sulfate. |
- General function:
- Involved in inositol trisphosphate 3-kinase activity
- Specific function:
- Has kinase activity and phosphorylates inositol-1,4,5- trisphosphate (Ins(1,4,5)P3) and inositol-1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4). Has low kinase activity towards InsP6. Originally it was proposed that the ARGRI and ARGRIII proteins are more likely to be involved in the control of ARGRII activity
- Gene Name:
- ARG82
- Uniprot ID:
- P07250
- Molecular weight:
- 40352.5
Reactions
| ATP + 1D-myo-inositol 1,4,5-trisphosphate → ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate. |
| ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate → ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate. |
- General function:
- Involved in phosphotransferase activity, alcohol group as acceptor
- Specific function:
- Catalyzes the committed step of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway. Also exhibits choline kinase activity but its preferred substrate is ethanolamine
- Gene Name:
- EKI1
- Uniprot ID:
- Q03764
- Molecular weight:
- 61656.39844
Reactions
| ATP + ethanolamine → ADP + O-phosphoethanolamine. |
- General function:
- Involved in phosphotransferase activity, alcohol group as acceptor
- Specific function:
- Responsible for phosphatidylcholine synthesis via the CDP-choline pathway. Also exhibits ethanolamine kinase activity but at 14% efficiency compared with choline
- Gene Name:
- CKI1
- Uniprot ID:
- P20485
- Molecular weight:
- 66316.0
Reactions
| ATP + choline → ADP + O-phosphocholine. |
- General function:
- Involved in catalytic activity
- Specific function:
- Synthesis of fructose 2,6-bisphosphate
- Gene Name:
- PFK27
- Uniprot ID:
- Q12471
- Molecular weight:
- 45317.10156
Reactions
| ATP + D-fructose 6-phosphate → ADP + beta-D-fructose 2,6-bisphosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Synthesis and degradation of fructose 2,6-bisphosphate
- Gene Name:
- Not Available
- Uniprot ID:
- Q06137
- Molecular weight:
- 58385.19922
Reactions
| Beta-D-fructose 2,6-bisphosphate + H(2)O → D-fructose 6-phosphate + phosphate. |
| ATP + D-fructose 6-phosphate → ADP + beta-D-fructose 2,6-bisphosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Synthesis of fructose 2,6-bisphosphate
- Gene Name:
- PFK26
- Uniprot ID:
- P40433
- Molecular weight:
- 93416.20313
Reactions
| ATP + D-fructose 6-phosphate → ADP + beta-D-fructose 2,6-bisphosphate. |
- General function:
- Involved in inositol trisphosphate 3-kinase activity
- Specific function:
- Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance
- Gene Name:
- KCS1
- Uniprot ID:
- Q12494
- Molecular weight:
- 119549.0
Reactions
| ATP + 1D-myo-inositol hexakisphosphate → ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate. |
| ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate → ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown). |
- General function:
- Involved in acid phosphatase activity
- Specific function:
- Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP- InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2- InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer. Required for maintaining celllular integrity, normal growth and interactions with the ARP complex. Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability. Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth
- Gene Name:
- VIP1
- Uniprot ID:
- Q06685
- Molecular weight:
- 129754.0
Reactions
| ATP + 1D-myo-inositol hexakisphosphate → ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate. |
| ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate → ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown). |
| ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate → ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown). |
- General function:
- Involved in ATP binding
- Specific function:
- ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
- Gene Name:
- GSH2
- Uniprot ID:
- Q08220
- Molecular weight:
- 55814.69922
Reactions
| ATP + gamma-L-glutamyl-L-cysteine + glycine → ADP + phosphate + glutathione. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs
- Gene Name:
- GRS1
- Uniprot ID:
- P38088
- Molecular weight:
- 75410.20313
Reactions
| ATP + glycine + tRNA(Gly) → AMP + diphosphate + glycyl-tRNA(Gly). |
- General function:
- Involved in catalytic activity
- Specific function:
- ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide
- Gene Name:
- ADE5
- Uniprot ID:
- P07244
- Molecular weight:
- 86067.39844
Reactions
| ATP + 5-phospho-D-ribosylamine + glycine → ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. |
| ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine → ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs
- Gene Name:
- GRS2
- Uniprot ID:
- Q06817
- Molecular weight:
- 71017.89844
Reactions
| ATP + glycine + tRNA(Gly) → AMP + diphosphate + glycyl-tRNA(Gly). |
- General function:
- Involved in glycerone kinase activity
- Specific function:
- ATP + glycerone = ADP + glycerone phosphate
- Gene Name:
- DAK2
- Uniprot ID:
- P43550
- Molecular weight:
- 62134.0
Reactions
| ATP + glycerone → ADP + glycerone phosphate. |
- General function:
- Involved in glycerone kinase activity
- Specific function:
- ATP + glycerone = ADP + glycerone phosphate
- Gene Name:
- DAK1
- Uniprot ID:
- P54838
- Molecular weight:
- 62206.10156
Reactions
| ATP + glycerone → ADP + glycerone phosphate. |
- General function:
- Involved in phosphorus-oxygen lyase activity
- Specific function:
- Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP
- Gene Name:
- CYR1
- Uniprot ID:
- P08678
- Molecular weight:
- 227832.0
Reactions
| ATP → 3',5'-cyclic AMP + diphosphate. |
- General function:
- Involved in 3-dehydroquinate dehydratase activity
- Specific function:
- The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis
- Gene Name:
- ARO1
- Uniprot ID:
- P08566
- Molecular weight:
- 174754.0
Reactions
| 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate → 3-dehydroquinate + phosphate. |
| 3-dehydroquinate → 3-dehydroshikimate + H(2)O. |
| Shikimate + NADP(+) → 3-dehydroshikimate + NADPH. |
| ATP + shikimate → ADP + shikimate 3-phosphate. |
| Phosphoenolpyruvate + 3-phosphoshikimate → phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
- Gene Name:
- ISM1
- Uniprot ID:
- P48526
- Molecular weight:
- 115793.0
Reactions
| ATP + L-isoleucine + tRNA(Ile) → AMP + diphosphate + L-isoleucyl-tRNA(Ile). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
- Gene Name:
- ILS1
- Uniprot ID:
- P09436
- Molecular weight:
- 122982.0
Reactions
| ATP + L-isoleucine + tRNA(Ile) → AMP + diphosphate + L-isoleucyl-tRNA(Ile). |
- General function:
- Involved in catalytic activity
- Specific function:
- ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
- Gene Name:
- LSC1
- Uniprot ID:
- P53598
- Molecular weight:
- 35032.19922
Reactions
| ATP + succinate + CoA → ADP + phosphate + succinyl-CoA. |
- General function:
- Involved in catalytic activity
- Specific function:
- Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Contributes, with FAA1, to the activation of imported myristate
- Gene Name:
- FAA4
- Uniprot ID:
- P47912
- Molecular weight:
- 77266.5
Reactions
| ATP + a long-chain carboxylic acid + CoA → AMP + diphosphate + an acyl-CoA. |
- General function:
- Involved in catalytic activity
- Specific function:
- Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It may supplement intracellular myristoyl-CoA pools from exogenous myristate. Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities
- Gene Name:
- FAA1
- Uniprot ID:
- P30624
- Molecular weight:
- 77865.79688
Reactions
| ATP + a long-chain carboxylic acid + CoA → AMP + diphosphate + an acyl-CoA. |
- General function:
- Involved in dephospho-CoA kinase activity
- Specific function:
- Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
- Gene Name:
- CAB5
- Uniprot ID:
- Q03941
- Molecular weight:
- 27339.5
Reactions
| ATP + 3'-dephospho-CoA → ADP + CoA. |
- General function:
- Involved in catalytic activity
- Specific function:
- Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. This enzyme acts preferentially on C16 and C18 fatty acids with a cis-double bond at C-9-C-10
- Gene Name:
- FAA3
- Uniprot ID:
- P39002
- Molecular weight:
- 77946.0
Reactions
| ATP + a long-chain carboxylic acid + CoA → AMP + diphosphate + an acyl-CoA. |
- General function:
- Involved in acetate-CoA ligase activity
- Specific function:
- Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Aerobic" isozyme of acetyl-coenzyme A synthetase, which supports growth on nonfermentable carbon sources such as glycerol and ethanol. May be required for assimilation of ethanol and acetate
- Gene Name:
- ACS1
- Uniprot ID:
- Q01574
- Molecular weight:
- 79140.10156
Reactions
| ATP + acetate + CoA → AMP + diphosphate + acetyl-CoA. |
- General function:
- Involved in acetate-CoA ligase activity
- Specific function:
- Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Anaerobic" isozyme of acetyl-coenzyme A synthetase, which is required for growth on fermentable carbon sources such as glucose. May be involved in the PDH (pyruvate dehydrogenase complex) bypass
- Gene Name:
- ACS2
- Uniprot ID:
- P52910
- Molecular weight:
- 75491.10156
Reactions
| ATP + acetate + CoA → AMP + diphosphate + acetyl-CoA. |
- General function:
- Involved in catalytic activity
- Specific function:
- Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Preferentially acts on C9:0-C13:0 fatty acids although C7:0-C17:0 fatty acids are tolerated
- Gene Name:
- FAA2
- Uniprot ID:
- P39518
- Molecular weight:
- 83437.10156
Reactions
| ATP + a long-chain carboxylic acid + CoA → AMP + diphosphate + an acyl-CoA. |
- General function:
- Involved in catalytic activity
- Specific function:
- ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
- Gene Name:
- LSC2
- Uniprot ID:
- P53312
- Molecular weight:
- 46900.30078
Reactions
| ATP + succinate + CoA → ADP + phosphate + succinyl-CoA. |
- General function:
- Involved in glutamate-cysteine ligase activity
- Specific function:
- ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
- Gene Name:
- GSH1
- Uniprot ID:
- P32477
- Molecular weight:
- 78252.89844
Reactions
| ATP + L-glutamate + L-cysteine → ADP + phosphate + gamma-L-glutamyl-L-cysteine. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)
- Gene Name:
- Not Available
- Uniprot ID:
- P53852
- Molecular weight:
- 87529.5
Reactions
| ATP + L-cysteine + tRNA(Cys) → AMP + diphosphate + L-cysteinyl-tRNA(Cys). |
- General function:
- Involved in acetylglutamate kinase activity
- Specific function:
- N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH
- Gene Name:
- ARG5
- Uniprot ID:
- Q01217
- Molecular weight:
- 94868.39844
Reactions
| N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate → N-acetyl-5-glutamyl phosphate + NADPH. |
| ATP + N-acetyl-L-glutamate → ADP + N-acetyl-L-glutamate 5-phosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- ATP + uridine = ADP + UMP
- Gene Name:
- Not Available
- Uniprot ID:
- Q12084
- Molecular weight:
- 26594.80078
Reactions
| ATP + uridine → ADP + UMP. |
| ATP + cytidine → ADP + CMP. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Has equal high activity toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate. Has no activity toward GMP. Required for Golgi glycosylation and cell wall integrity. Together with CDC55, required for adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity, the apyrase activity is not required for this function. Plays a role in sphingolipid synthesis
- Gene Name:
- YND1
- Uniprot ID:
- P40009
- Molecular weight:
- 71851.20313
Reactions
| ATP + 2 H(2)O → AMP + 2 phosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- Furnishes the cell with pyrimidines. Accepts UMP, and dUMP as phosphate acceptors with high activity; to a lesser extent, it can also use IMP, GMP, dGMP, 5-iodo-dUMP, XMP, and dTMP as substrates. ATP and dATP are the best phosphate donors; can use GTP, dGTP, dCTP, and dTTP to some degree (30-50%)
- Gene Name:
- URA6
- Uniprot ID:
- P15700
- Molecular weight:
- 22933.0
Reactions
| ATP + UMP → ADP + UDP. |
- General function:
- Involved in ATP binding
- Specific function:
- Catalyzes the conversion of uridine into UMP and cytidine into CMP in the pyrimidine salvage pathway
- Gene Name:
- URK1
- Uniprot ID:
- P27515
- Molecular weight:
- 56295.5
Reactions
| ATP + uridine → ADP + UMP. |
| ATP + cytidine → ADP + CMP. |
- General function:
- Involved in argininosuccinate synthase activity
- Specific function:
- In yeast, as can have a catabolic function since it allows efficient utilization of citrulline via arginine and the reactions involved in the arginase pathway
- Gene Name:
- ARG1
- Uniprot ID:
- P22768
- Molecular weight:
- 46939.30078
Reactions
| ATP + L-citrulline + L-aspartate → AMP + diphosphate + N(omega)-(L-arginino)succinate. |
- General function:
- Involved in nucleoside diphosphate kinase activity
- Specific function:
- Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Required for repair of UV radiation- and etoposide-induced DNA damage
- Gene Name:
- YNK1
- Uniprot ID:
- P36010
- Molecular weight:
- 17166.59961
Reactions
| ATP + nucleoside diphosphate → ADP + nucleoside triphosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- RAR (regulation of autonomous replication) is a protein whose activity increases the mitotic stability of plasmids
- Gene Name:
- ERG12
- Uniprot ID:
- P07277
- Molecular weight:
- 48458.89844
Reactions
| ATP + (R)-mevalonate → ADP + (R)-5-phosphomevalonate. |
- General function:
- Involved in phosphoribosylaminoimidazole carboxylase activity
- Specific function:
- 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)
- Gene Name:
- ADE2
- Uniprot ID:
- P21264
- Molecular weight:
- 62338.69922
Reactions
| 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate → 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2). |
- General function:
- Involved in ATP binding
- Specific function:
- Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose
- Gene Name:
- HXK2
- Uniprot ID:
- P04807
- Molecular weight:
- 53942.0
Reactions
| ATP + D-hexose → ADP + D-hexose 6-phosphate. |
| ATP + D-fructose → ADP + D-fructose 1-phosphate |
- General function:
- Involved in ATP binding
- Specific function:
- ATP + D-hexose = ADP + D-hexose 6-phosphate
- Gene Name:
- Not Available
- Uniprot ID:
- Q06204
- Molecular weight:
- 48968.80078
Reactions
| ATP + D-hexose → ADP + D-hexose 6-phosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- ATP + D-hexose = ADP + D-hexose 6-phosphate
- Gene Name:
- HXK1
- Uniprot ID:
- P04806
- Molecular weight:
- 53737.89844
Reactions
| ATP + D-hexose → ADP + D-hexose 6-phosphate. |
| ATP + D-fructose → ADP + D-fructose 1-phosphate |
- General function:
- Involved in phosphotransferase activity, alcohol group as acceptor
- Specific function:
- ATP + glycerol = ADP + sn-glycerol 3- phosphate
- Gene Name:
- GUT1
- Uniprot ID:
- P32190
- Molecular weight:
- 79823.60156
Reactions
| ATP + glycerol → ADP + sn-glycerol 3-phosphate. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin
- Gene Name:
- BIO4
- Uniprot ID:
- P53630
- Molecular weight:
- 26256.69922
Reactions
| ATP + 7,8-diaminononanoate + CO(2) → ADP + phosphate + dethiobiotin. |
- General function:
- Involved in ATP binding
- Specific function:
- ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate
- Gene Name:
- ADE1
- Uniprot ID:
- P27616
- Molecular weight:
- 34603.10156
Reactions
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate → ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. |
- General function:
- Involved in 6-phosphofructokinase activity
- Specific function:
- ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate
- Gene Name:
- PFK1
- Uniprot ID:
- P16861
- Molecular weight:
- 107969.0
Reactions
| ATP + D-fructose 6-phosphate → ADP + D-fructose 1,6-bisphosphate. |
- General function:
- Involved in 6-phosphofructokinase activity
- Specific function:
- ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate
- Gene Name:
- PFK2
- Uniprot ID:
- P16862
- Molecular weight:
- 104617.0
Reactions
| ATP + D-fructose 6-phosphate → ADP + D-fructose 1,6-bisphosphate. |
- General function:
- Involved in tetrahydrofolylpolyglutamate synthase activity
- Specific function:
- Conversion of folates to polyglutamate derivatives
- Gene Name:
- FOL3
- Uniprot ID:
- Q12676
- Molecular weight:
- 47850.80078
Reactions
| ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate → ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1). |
- General function:
- Involved in formate-tetrahydrofolate ligase activity
- Specific function:
- 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH
- Gene Name:
- MIS1
- Uniprot ID:
- P09440
- Molecular weight:
- 106216.0
Reactions
| 5,10-methylenetetrahydrofolate + NADP(+) → 5,10-methenyltetrahydrofolate + NADPH. |
| 5,10-methenyltetrahydrofolate + H(2)O → 10-formyltetrahydrofolate. |
| ATP + formate + tetrahydrofolate → ADP + phosphate + 10-formyltetrahydrofolate. |
- General function:
- Involved in formate-tetrahydrofolate ligase activity
- Specific function:
- 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH
- Gene Name:
- ADE3
- Uniprot ID:
- P07245
- Molecular weight:
- 102204.0
Reactions
| 5,10-methylenetetrahydrofolate + NADP(+) → 5,10-methenyltetrahydrofolate + NADPH. |
| 5,10-methenyltetrahydrofolate + H(2)O → 10-formyltetrahydrofolate. |
| ATP + formate + tetrahydrofolate → ADP + phosphate + 10-formyltetrahydrofolate. |
- General function:
- Involved in riboflavin kinase activity
- Specific function:
- Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme
- Gene Name:
- FMN1
- Uniprot ID:
- Q03778
- Molecular weight:
- 24536.90039
Reactions
| ATP + riboflavin → ADP + FMN. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme
- Gene Name:
- FAD1
- Uniprot ID:
- P38913
- Molecular weight:
- 35545.80078
Reactions
| ATP + FMN → diphosphate + FAD. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
- Gene Name:
- AIM10
- Uniprot ID:
- P39965
- Molecular weight:
- 65879.70313
Reactions
| ATP + L-proline + tRNA(Pro) → AMP + diphosphate + L-prolyl-tRNA(Pro). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)
- Gene Name:
- MSR1
- Uniprot ID:
- P38714
- Molecular weight:
- 73693.39844
Reactions
| ATP + L-arginine + tRNA(Arg) → AMP + diphosphate + L-arginyl-tRNA(Arg). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)
- Gene Name:
- MSW1
- Uniprot ID:
- P04803
- Molecular weight:
- 43015.10156
Reactions
| ATP + L-tryptophan + tRNA(Trp) → AMP + diphosphate + L-tryptophyl-tRNA(Trp). |
- General function:
- Involved in magnesium ion binding
- Specific function:
- 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1- diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)
- Gene Name:
- PRS5
- Uniprot ID:
- Q12265
- Molecular weight:
- 53504.19922
Reactions
| ATP + D-ribose 5-phosphate → AMP + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis
- Gene Name:
- Not Available
- Uniprot ID:
- Q05506
- Molecular weight:
- 69524.39844
Reactions
| ATP + L-arginine + tRNA(Arg) → AMP + diphosphate + L-arginyl-tRNA(Arg). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins
- Gene Name:
- MSF1
- Uniprot ID:
- P08425
- Molecular weight:
- 54828.39844
Reactions
| ATP + L-phenylalanine + tRNA(Phe) → AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)
- Gene Name:
- VAS1
- Uniprot ID:
- P07806
- Molecular weight:
- 125769.0
Reactions
| ATP + L-valine + tRNA(Val) → AMP + diphosphate + L-valyl-tRNA(Val). |
- General function:
- Involved in magnesium ion binding
- Specific function:
- 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1- diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)
- Gene Name:
- PRS2
- Uniprot ID:
- P38620
- Molecular weight:
- 34764.60156
Reactions
| ATP + D-ribose 5-phosphate → AMP + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)
- Gene Name:
- MST1
- Uniprot ID:
- P07236
- Molecular weight:
- 54091.60156
Reactions
| ATP + L-threonine + tRNA(Thr) → AMP + diphosphate + L-threonyl-tRNA(Thr). |
- General function:
- Involved in magnesium ion binding
- Specific function:
- 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1- diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)
- Gene Name:
- PRS1
- Uniprot ID:
- P32895
- Molecular weight:
- 47047.0
Reactions
| ATP + D-ribose 5-phosphate → AMP + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
- Gene Name:
- CDC60
- Uniprot ID:
- P26637
- Molecular weight:
- 124140.0
Reactions
| ATP + L-leucine + tRNA(Leu) → AMP + diphosphate + L-leucyl-tRNA(Leu). |
- General function:
- Involved in RNA binding
- Specific function:
- ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)
- Gene Name:
- FRS1
- Uniprot ID:
- P15624
- Molecular weight:
- 67364.29688
Reactions
| ATP + L-phenylalanine + tRNA(Phe) → AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
- General function:
- Involved in thiamine diphosphokinase activity
- Specific function:
- Essential protein, it is the only enzyme in yeast capable of synthesizing thiamine pyrophosphate (TPP)
- Gene Name:
- THI80
- Uniprot ID:
- P35202
- Molecular weight:
- 36615.69922
Reactions
| ATP + thiamine → AMP + thiamine diphosphate. |
- General function:
- Involved in biotin-[acetyl-CoA-carboxylase] ligase activity
- Specific function:
- Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase
- Gene Name:
- BPL1
- Uniprot ID:
- P48445
- Molecular weight:
- 76362.39844
Reactions
| ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase] → AMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxytransferase]. |
| ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] → AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]. |
| ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] → AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]. |
| ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] → AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)
- Gene Name:
- FRS2
- Uniprot ID:
- P15625
- Molecular weight:
- 57511.0
Reactions
| ATP + L-phenylalanine + tRNA(Phe) → AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
- Gene Name:
- NAM2
- Uniprot ID:
- P11325
- Molecular weight:
- 101920.0
Reactions
| ATP + L-leucine + tRNA(Leu) → AMP + diphosphate + L-leucyl-tRNA(Leu). |
- General function:
- Involved in ATP binding
- Specific function:
- This small ubiquitous enzyme is essential for maintenance and cell growth
- Gene Name:
- ADK2
- Uniprot ID:
- P26364
- Molecular weight:
- 25193.69922
Reactions
| ATP + AMP → 2 ADP. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
- Gene Name:
- MSM1
- Uniprot ID:
- P22438
- Molecular weight:
- 66733.89844
Reactions
| ATP + L-methionine + tRNA(Met) → AMP + diphosphate + L-methionyl-tRNA(Met). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)
- Gene Name:
- WRS1
- Uniprot ID:
- Q12109
- Molecular weight:
- 49350.0
Reactions
| ATP + L-tryptophan + tRNA(Trp) → AMP + diphosphate + L-tryptophyl-tRNA(Trp). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)
- Gene Name:
- HTS1
- Uniprot ID:
- P07263
- Molecular weight:
- 59952.0
Reactions
| ATP + L-histidine + tRNA(His) → AMP + diphosphate + L-histidyl-tRNA(His). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
- Gene Name:
- SES1
- Uniprot ID:
- P07284
- Molecular weight:
- 53309.19922
Reactions
| ATP + L-serine + tRNA(Ser) → AMP + diphosphate + L-seryl-tRNA(Ser). |
| ATP + L-serine + tRNA(Sec) → AMP + diphosphate + L-seryl-tRNA(Sec). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
- Gene Name:
- MSE1
- Uniprot ID:
- P48525
- Molecular weight:
- 61602.69922
Reactions
| ATP + L-glutamate + tRNA(Glu) → AMP + diphosphate + L-glutamyl-tRNA(Glu). |
- General function:
- Nucleotide transport and metabolism
- Specific function:
- Required for the activation of POS9 and for stabilizing its interaction with the transcriptosome in response to oxidative stress. Required for 20S rRNA processing at site D
- Gene Name:
- FAP7
- Uniprot ID:
- Q12055
- Molecular weight:
- 22723.0
Reactions
| ATP + AMP → 2 ADP. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
- Gene Name:
- MES1
- Uniprot ID:
- P00958
- Molecular weight:
- 85677.39844
Reactions
| ATP + L-methionine + tRNA(Met) → AMP + diphosphate + L-methionyl-tRNA(Met). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction:alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain
- Gene Name:
- ALA1
- Uniprot ID:
- P40825
- Molecular weight:
- 107276.0
Reactions
| ATP + L-alanine + tRNA(Ala) → AMP + diphosphate + L-alanyl-tRNA(Ala). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)
- Gene Name:
- SLM5
- Uniprot ID:
- P25345
- Molecular weight:
- 56784.39844
Reactions
| ATP + L-asparagine + tRNA(Asn) → AMP + diphosphate + L-asparaginyl-tRNA(Asn). |
- General function:
- Involved in magnesium ion binding
- Specific function:
- 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1- diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)
- Gene Name:
- PRS3
- Uniprot ID:
- P38689
- Molecular weight:
- 35123.30078
Reactions
| ATP + D-ribose 5-phosphate → AMP + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in the cytoplasm and mitochondrion intermembrane space
- Gene Name:
- ADK1
- Uniprot ID:
- P07170
- Molecular weight:
- 24254.5
Reactions
| ATP + AMP → 2 ADP. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
- Gene Name:
- DIA4
- Uniprot ID:
- P38705
- Molecular weight:
- 50389.5
Reactions
| ATP + L-serine + tRNA(Ser) → AMP + diphosphate + L-seryl-tRNA(Ser). |
| ATP + L-serine + tRNA(Sec) → AMP + diphosphate + L-seryl-tRNA(Sec). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
- Gene Name:
- MSY1
- Uniprot ID:
- P48527
- Molecular weight:
- 55286.89844
Reactions
| ATP + L-tyrosine + tRNA(Tyr) → AMP + diphosphate + L-tyrosyl-tRNA(Tyr). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)
- Gene Name:
- MSD1
- Uniprot ID:
- P15179
- Molecular weight:
- 75460.0
Reactions
| ATP + L-aspartate + tRNA(Asp) → AMP + diphosphate + L-aspartyl-tRNA(Asp). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)
- Gene Name:
- MSK1
- Uniprot ID:
- P32048
- Molecular weight:
- 66127.60156
Reactions
| ATP + L-lysine + tRNA(Lys) → AMP + diphosphate + L-lysyl-tRNA(Lys). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)
- Gene Name:
- KRS1
- Uniprot ID:
- P15180
- Molecular weight:
- 67958.0
Reactions
| ATP + L-lysine + tRNA(Lys) → AMP + diphosphate + L-lysyl-tRNA(Lys). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)
- Gene Name:
- DED81
- Uniprot ID:
- P38707
- Molecular weight:
- 62206.30078
Reactions
| ATP + L-asparagine + tRNA(Asn) → AMP + diphosphate + L-asparaginyl-tRNA(Asn). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
- Gene Name:
- Not Available
- Uniprot ID:
- P38708
- Molecular weight:
- 77385.70313
Reactions
| ATP + L-proline + tRNA(Pro) → AMP + diphosphate + L-prolyl-tRNA(Pro). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). The specificity determinants on tRNA(Tyr) are the base pair C1-G72, the discriminator residue A73, and the three anticodon bases G34, U35 and A36. Also involved in nuclear tRNA export
- Gene Name:
- TYS1
- Uniprot ID:
- P36421
- Molecular weight:
- 44019.60156
Reactions
| ATP + L-tyrosine + tRNA(Tyr) → AMP + diphosphate + L-tyrosyl-tRNA(Tyr). |
- General function:
- Involved in ligase activity
- Specific function:
- Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha- aminoadipate by NADPH
- Gene Name:
- LYS2
- Uniprot ID:
- P07702
- Molecular weight:
- 155344.0
Reactions
| L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O → L-2-aminoadipate + NAD(P)H. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)
- Gene Name:
- THS1
- Uniprot ID:
- P04801
- Molecular weight:
- 84519.79688
Reactions
| ATP + L-threonine + tRNA(Thr) → AMP + diphosphate + L-threonyl-tRNA(Thr). |
- General function:
- Involved in ATP binding
- Specific function:
- Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)
- Gene Name:
- NRK1
- Uniprot ID:
- P53915
- Molecular weight:
- 27689.30078
Reactions
| ATP + N-ribosylnicotinamide → ADP + nicotinamide ribonucleotide. |
| ATP + D-ribosylnicotinate → ADP + nicotinate D-ribonucleotide. |
- General function:
- Involved in ATP binding
- Specific function:
- Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate
- Gene Name:
- THR1
- Uniprot ID:
- P17423
- Molecular weight:
- 38712.0
Reactions
| ATP + L-homoserine → ADP + O-phospho-L-homoserine. |
- General function:
- Involved in ATP binding
- Specific function:
- Has kinase activity and phosphorylates inositol- 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate
- Gene Name:
- IPK1
- Uniprot ID:
- Q06667
- Molecular weight:
- 32917.69922
Reactions
| ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate → ADP + 1D-myo-inositol hexakisphosphate. |
- General function:
- Involved in hydrolase activity
- Specific function:
- Not Available
- Gene Name:
- Not Available
- Uniprot ID:
- P28273
- Molecular weight:
- 140426.0
Reactions
| ATP + 5-oxo-L-proline + 2 H(2)O → ADP + phosphate + L-glutamate. |
- General function:
- Involved in phosphotransferase activity, alcohol group as acceptor
- Specific function:
- ATP + D-ribose = ADP + D-ribose 5-phosphate
- Gene Name:
- RBK1
- Uniprot ID:
- P25332
- Molecular weight:
- 36923.80078
Reactions
| ATP + D-ribose → ADP + D-ribose 5-phosphate. |
- General function:
- Involved in methionine adenosyltransferase activity
- Specific function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP
- Gene Name:
- SAM1
- Uniprot ID:
- P10659
- Molecular weight:
- 41818.0
Reactions
| ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine. |
- General function:
- Involved in nucleotidyltransferase activity
- Specific function:
- ATP + nicotinamide ribonucleotide = diphosphate + NAD(+);ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+
- Gene Name:
- NMA2
- Uniprot ID:
- P53204
- Molecular weight:
- 44908.69922
Reactions
| ATP + nicotinamide ribonucleotide → diphosphate + NAD(+). |
| ATP + nicotinate ribonucleotide → diphosphate + deamido-NAD+ |
- General function:
- Involved in diacylglycerol kinase activity
- Specific function:
- Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Involved in the biosynthesis of sphingolipids and ceramides. Required with LCB3 for an effective incorporation of DHS into ceramides through a phosphorylation-dephosphorylation cycle. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance
- Gene Name:
- LCB4
- Uniprot ID:
- Q12246
- Molecular weight:
- 69638.60156
Reactions
| ATP + sphinganine → ADP + sphinganine 1-phosphate. |
| ATP + phytosphingosine → ADP + phytosphingosine 1-phosphate. |
- General function:
- Involved in acetyl-CoA carboxylase activity
- Specific function:
- Catalyzes the rate-limiting reaction in the mitochondrial fatty acid synthesis (FAS) type II pathway. Responsible for the production of the mitochondrial malonyl-CoA, used for the biosynthesis of the cofactor lipoic acid. This protein carries three functions:biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase
- Gene Name:
- HFA1
- Uniprot ID:
- P32874
- Molecular weight:
- 259161.0
Reactions
| ATP + acetyl-CoA + HCO(3)(-) → ADP + phosphate + malonyl-CoA. |
| ATP + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein]. |
- General function:
- Involved in diacylglycerol kinase activity
- Specific function:
- Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Redundant to LCB4, is only responsible for few percent of the total activity. Involved in the biosynthesis of sphingolipids and ceramides. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance
- Gene Name:
- LCB5
- Uniprot ID:
- Q06147
- Molecular weight:
- 77564.60156
Reactions
| ATP + sphinganine → ADP + sphinganine 1-phosphate. |
| ATP + phytosphingosine → ADP + phytosphingosine 1-phosphate. |
- General function:
- Involved in nucleotidyltransferase activity
- Specific function:
- ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)
- Gene Name:
- NMA1
- Uniprot ID:
- Q06178
- Molecular weight:
- 45858.60156
Reactions
| ATP + nicotinamide ribonucleotide → diphosphate + NAD(+). |
- General function:
- Involved in phosphotransferase activity, alcohol group as acceptor
- Specific function:
- May play a role in endocytic and/or exocytic pathways
- Gene Name:
- LSB6
- Uniprot ID:
- P42951
- Molecular weight:
- 70216.39844
Reactions
| ATP + 1-phosphatidyl-1D-myo-inositol → ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- Catalyzes the synthesis of activated sulfate
- Gene Name:
- MET14
- Uniprot ID:
- Q02196
- Molecular weight:
- 23060.09961
Reactions
| ATP + adenylyl sulfate → ADP + 3'-phosphoadenylyl sulfate. |
- General function:
- Involved in pyridoxal kinase activity
- Specific function:
- Required for synthesis of pyridoxal-5-phosphate from vitamin B6. Important for bud site selection
- Gene Name:
- BUD16
- Uniprot ID:
- P39988
- Molecular weight:
- 35558.89844
Reactions
| ATP + pyridoxal → ADP + pyridoxal 5'-phosphate. |
- General function:
- Involved in NAD+ kinase activity
- Specific function:
- Specifically phosphorylates NAD in the presence of ATP, dATP, or CTP as phosphoryl donors
- Gene Name:
- UTR1
- Uniprot ID:
- P21373
- Molecular weight:
- 59468.69922
Reactions
| ATP + NAD(+) → ADP + NADP(+). |
- General function:
- Involved in catalytic activity
- Specific function:
- Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
- Gene Name:
- PYC1
- Uniprot ID:
- P11154
- Molecular weight:
- 130098.0
Reactions
| ATP + pyruvate + HCO(3)(-) → ADP + phosphate + oxaloacetate. |
- General function:
- Involved in ATP binding
- Specific function:
- ATP + (R)-5-phosphomevalonate = ADP + (R)-5- diphosphomevalonate
- Gene Name:
- ERG8
- Uniprot ID:
- P24521
- Molecular weight:
- 50454.39844
Reactions
| ATP + (R)-5-phosphomevalonate → ADP + (R)-5-diphosphomevalonate. |
- General function:
- Involved in pyridoxal kinase activity
- Specific function:
- Required for synthesis of pyridoxal-5-phosphate from vitamin B6. Important for bud site selection
- Gene Name:
- BUD17
- Uniprot ID:
- P53727
- Molecular weight:
- 35366.5
Reactions
| ATP + pyridoxal → ADP + pyridoxal 5'-phosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- ATP + D-gluconate = ADP + 6-phospho-D- gluconate
- Gene Name:
- Not Available
- Uniprot ID:
- Q03786
- Molecular weight:
- 22174.5
Reactions
| ATP + D-gluconate → ADP + 6-phospho-D-gluconate. |
- General function:
- Involved in cellular amino acid biosynthetic process
- Specific function:
- Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline
- Gene Name:
- PRO1
- Uniprot ID:
- P32264
- Molecular weight:
- 47161.69922
Reactions
| ATP + L-glutamate → ADP + L-glutamate 5-phosphate. |
- General function:
- Involved in RNA binding
- Specific function:
- This enzyme carries out synthesis of the tRNA CCA terminus without the direction of a template using the multiple accepting and donating subsites within its active site
- Gene Name:
- CCA1
- Uniprot ID:
- P21269
- Molecular weight:
- 62484.39844
Reactions
| A tRNA precursor + 2 CTP + ATP → a tRNA with a 3' CCA end + 3 diphosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- PI-SceI is an endonuclease that can cleave at a site present in a VMA1 allele that lacks the derived endonuclease segment of the open reading frame; cleavage at this site only occurs during meiosis and initiates "homing", a genetic event that converts a VMA1 allele lacking VDE into one that contains it
- Gene Name:
- TFP1
- Uniprot ID:
- P17255
- Molecular weight:
- 118636.0
Reactions
| ATP + H(2)O + H(+)(In) → ADP + phosphate + H(+)(Out). |
- General function:
- Involved in ATP binding
- Specific function:
- ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2)
- Gene Name:
- MVD1
- Uniprot ID:
- P32377
- Molecular weight:
- 44115.5
Reactions
| ATP + (R)-5-diphosphomevalonate → ADP + phosphate + isopentenyl diphosphate + CO(2). |
- General function:
- Involved in phosphomethylpyrimidine kinase activity
- Specific function:
- Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and also probaby that of HMP to HMP- P
- Gene Name:
- THI21
- Uniprot ID:
- Q08975
- Molecular weight:
- 61333.69922
Reactions
| ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine → ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine. |
| ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine → ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine. |
- General function:
- Involved in phosphomethylpyrimidine kinase activity
- Specific function:
- Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and also probaby that of HMP to HMP- P
- Gene Name:
- THI20
- Uniprot ID:
- Q08224
- Molecular weight:
- 61268.89844
Reactions
| ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine → ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine. |
| ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine → ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine. |
| thiamine + H2O → 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole. |
- General function:
- Involved in nucleotidyltransferase activity
- Specific function:
- Not Available
- Gene Name:
- Not Available
- Uniprot ID:
- P53332
- Molecular weight:
- 34306.30078
Reactions
| ATP + pantetheine 4'-phosphate → diphosphate + 3'-dephospho-CoA. |
- General function:
- Involved in pantothenate kinase activity
- Specific function:
- Plays a role in the physiological regulation of the intracellular CoA concentration
- Gene Name:
- Not Available
- Uniprot ID:
- Q04430
- Molecular weight:
- 40902.89844
Reactions
| ATP + (R)-pantothenate → ADP + (R)-4'-phosphopantothenate. |
- General function:
- Involved in amino acid binding
- Specific function:
- ATP + L-aspartate = ADP + 4-phospho-L- aspartate
- Gene Name:
- HOM3
- Uniprot ID:
- P10869
- Molecular weight:
- 58109.19922
Reactions
| ATP + L-aspartate → ADP + 4-phospho-L-aspartate. |
- General function:
- Involved in acetyl-CoA carboxylase activity
- Specific function:
- Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase
- Gene Name:
- FAS3
- Uniprot ID:
- Q00955
- Molecular weight:
- 250351.0
Reactions
| ATP + acetyl-CoA + HCO(3)(-) → ADP + phosphate + malonyl-CoA. |
| ATP + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein]. |
- General function:
- Involved in thymidylate kinase activity
- Specific function:
- Catalyzes the conversion of dTMP to dTDP
- Gene Name:
- CDC8
- Uniprot ID:
- P00572
- Molecular weight:
- 24687.19922
Reactions
| ATP + dTMP → ADP + dTDP. |
- General function:
- Involved in binding
- Specific function:
- Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. STT4 functions in PKC1 protein kinase pathway
- Gene Name:
- STT4
- Uniprot ID:
- P37297
- Molecular weight:
- 214605.0
Reactions
| ATP + 1-phosphatidyl-1D-myo-inositol → ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses
- Gene Name:
- PMA1
- Uniprot ID:
- P05030
- Molecular weight:
- 99618.39844
Reactions
| ATP + H(2)O + H(+)(In) → ADP + phosphate + H(+)(Out). |
- General function:
- Involved in DNA binding
- Specific function:
- Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxin TSA1. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and as thioltransferase
- Gene Name:
- SRX1
- Uniprot ID:
- P36077
- Molecular weight:
- 13853.90039
Reactions
| Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH → peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- ATP + pyruvate = ADP + phosphoenolpyruvate
- Gene Name:
- PYK1
- Uniprot ID:
- P00549
- Molecular weight:
- 54544.10156
Reactions
| ATP + pyruvate → ADP + phosphoenolpyruvate. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- May be used by cells under conditions in which the level of glycolytic flux is very low
- Gene Name:
- PYK2
- Uniprot ID:
- P52489
- Molecular weight:
- 55194.69922
Reactions
| ATP + pyruvate → ADP + phosphoenolpyruvate. |
- General function:
- Involved in ATP binding
- Specific function:
- Putative glucokinase involved in phosphorylation of aldohexoses and glucose uptake. Involved in sporulation. Required for the full activation of the early meiotic inducer IME1
- Gene Name:
- EMI2
- Uniprot ID:
- Q04409
- Molecular weight:
- 55920.30078
Reactions
| ATP + D-glucose → ADP + D-glucose 6-phosphate. |
- General function:
- Involved in ATP phosphoribosyltransferase activity
- Specific function:
- Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity
- Gene Name:
- HIS1
- Uniprot ID:
- P00498
- Molecular weight:
- 32266.09961
Reactions
| 1-(5-phospho-D-ribosyl)-ATP + diphosphate → ATP + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in ATP adenylyltransferase activity
- Specific function:
- Sustains the catabolism of Np-4-N' nucleotides, rather than their synthesis
- Gene Name:
- APA2
- Uniprot ID:
- P22108
- Molecular weight:
- 36840.5
Reactions
| ADP + ATP → phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate. |
- General function:
- Involved in tetrahydrofolylpolyglutamate synthase activity
- Specific function:
- Conversion of folates to polyglutamate derivatives
- Gene Name:
- RMA1
- Uniprot ID:
- P36001
- Molecular weight:
- 48142.89844
Reactions
| ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate → ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1). |
- General function:
- Involved in protein binding
- Specific function:
- Essential for recycling GMP and indirectly, cGMP
- Gene Name:
- GUK1
- Uniprot ID:
- P15454
- Molecular weight:
- 20637.19922
Reactions
| ATP + GMP → ADP + GDP. |
- General function:
- Involved in nucleotide binding
- Specific function:
- The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses
- Gene Name:
- PMA2
- Uniprot ID:
- P19657
- Molecular weight:
- 102171.0
Reactions
| ATP + H(2)O + H(+)(In) → ADP + phosphate + H(+)(Out). |
- General function:
- Involved in binding
- Specific function:
- Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy- specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3- kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Its activation by VPS15 may lead to the phosphorylation of phosphatidylinositol in the sorting compartment membrane. Finally, it might also be involved in ethanol tolerance and cell wall integrity
- Gene Name:
- VPS34
- Uniprot ID:
- P22543
- Molecular weight:
- 100920.0
Reactions
| ATP + 1-phosphatidyl-1D-myo-inositol → ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. |
- General function:
- Involved in phosphoenolpyruvate carboxykinase (ATP) activity
- Specific function:
- ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO(2)
- Gene Name:
- PCK1
- Uniprot ID:
- P10963
- Molecular weight:
- 60982.69922
Reactions
| ATP + oxaloacetate → ADP + phosphoenolpyruvate + CO(2). |
- General function:
- Involved in catalytic activity
- Specific function:
- Essential for thiamine biosynthesis. The kinase activity is involved in the salvage synthesis of TH-P from the thiazole
- Gene Name:
- THI6
- Uniprot ID:
- P41835
- Molecular weight:
- 58058.19922
Reactions
| 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole → diphosphate + thiamine phosphate. |
| ATP + 4-methyl-5-(2-hydroxyethyl)thiazole → ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. |
- General function:
- Involved in ATP binding
- Specific function:
- Two isoenzymes, hexokinase-1 and hexokinase-2, can phosphorylate keto- and aldohexoses in yeast, whereas a third isoenzyme, GLK, is specific for aldohexoses. All glucose phosphorylating enzymes are involved in glucose uptake
- Gene Name:
- GLK1
- Uniprot ID:
- P17709
- Molecular weight:
- 55376.89844
Reactions
| ATP + D-glucose → ADP + D-glucose 6-phosphate. |
- General function:
- Involved in phosphoglycerate kinase activity
- Specific function:
- ATP + 3-phospho-D-glycerate = ADP + 3-phospho- D-glyceroyl phosphate
- Gene Name:
- PGK1
- Uniprot ID:
- P00560
- Molecular weight:
- 44738.0
Reactions
| ATP + 3-phospho-D-glycerate → ADP + 3-phospho-D-glyceroyl phosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits
- Gene Name:
- ATP2
- Uniprot ID:
- P00830
- Molecular weight:
- 54793.30078
Reactions
| ATP + H(2)O + H(+)(In) → ADP + phosphate + H(+)(Out). |
- General function:
- Involved in ATP binding
- Specific function:
- The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol-3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol-3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole. Hyperosmotic shock-induced increase in the levels of PtdIns(3,5)P2 requires the presence of VAC7, VAC14, and/or FIG4
- Gene Name:
- FAB1
- Uniprot ID:
- P34756
- Molecular weight:
- 257447.0
Reactions
| ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate → ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate. |
- General function:
- Involved in binding
- Specific function:
- Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. PIK1 is part of a nuclear phosphoinositide cycle and could control cytokinesis through the actin cytoskeleton
- Gene Name:
- PIK1
- Uniprot ID:
- P39104
- Molecular weight:
- 119922.0
Reactions
| ATP + 1-phosphatidyl-1D-myo-inositol → ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. |
- General function:
- Involved in phosphotransferase activity, alcohol group as acceptor
- Specific function:
- ATP + D-xylulose = ADP + D-xylulose 5- phosphate
- Gene Name:
- XKS1
- Uniprot ID:
- P42826
- Molecular weight:
- 68320.29688
Reactions
| ATP + D-xylulose → ADP + D-xylulose 5-phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
- Gene Name:
- PYC2
- Uniprot ID:
- P32327
- Molecular weight:
- 130166.0
Reactions
| ATP + pyruvate + HCO(3)(-) → ADP + phosphate + oxaloacetate. |
- General function:
- Involved in ATP binding
- Specific function:
- Utilizes 5-formyltetrahydrofolate (folinic acid) as substrate in an alternative way of folate biosynthesis
- Gene Name:
- FAU1
- Uniprot ID:
- P40099
- Molecular weight:
- 24058.5
Reactions
| ATP + 5-formyltetrahydrofolate → ADP + phosphate + 5,10-methenyltetrahydrofolate. |
- General function:
- Involved in NAD+ kinase activity
- Specific function:
- Phosphorylates both NADH and NAD(+), with a twofold preference for NADH. Anti-oxidant factor and key source of the cellular reductant NADPH
- Gene Name:
- POS5
- Uniprot ID:
- Q06892
- Molecular weight:
- 46246.5
Reactions
| ATP + NADH → ADP + NADPH. |
- General function:
- Involved in phosphatidylinositol phosphate kinase activity
- Specific function:
- Catalyzes the phosphorylation of phosphatidylinositol-4- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol-4,5-biphosphate. Acts downstream of STT4, but in a pathway that does not involve PKC1. May be involved in the organization of the actin cytoskeleton
- Gene Name:
- MSS4
- Uniprot ID:
- P38994
- Molecular weight:
- 89319.60156
Reactions
| ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate → ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Essential for thiamine biosynthesis
- Gene Name:
- THI22
- Uniprot ID:
- Q06490
- Molecular weight:
- 63306.39844
Reactions
- General function:
- Involved in nicotinate phosphoribosyltransferase activity
- Specific function:
- Essential for growth under anaerobic conditions
- Gene Name:
- NPT1
- Uniprot ID:
- P39683
- Molecular weight:
- 49018.19922
Reactions
| Nicotinate D-ribonucleotide + diphosphate → nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in electron carrier activity
- Specific function:
- Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl- hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER- derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism. Through its capacity to inactivate the stress response transcription factor YAP1 and its regulator the hydroperoxide stress sensor HYR1, it is involved in feedback regulation of stress response gene expression upon oxidative stress
- Gene Name:
- TRX2
- Uniprot ID:
- P22803
- Molecular weight:
- 11203.7998
Reactions
- General function:
- Involved in electron carrier activity
- Specific function:
- Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl- hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER- derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism
- Gene Name:
- TRX1
- Uniprot ID:
- P22217
- Molecular weight:
- 11234.90039
Reactions
- General function:
- Involved in inositol or phosphatidylinositol phosphatase activity
- Specific function:
- Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Specifically functions within the early endocytic pathway and actin organization
- Gene Name:
- INP52
- Uniprot ID:
- P50942
- Molecular weight:
- 133330.0
Reactions
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O → 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. |
| D-myo-inositol 1,4,5-trisphosphate + H2O → D-myo-inositol 1,4-bisphosphate + phosphate |
| D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O → D-myo-inositol 1,3,4-trisphosphate + phosphate |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Conversion of folates to polyglutamate derivatives
- Gene Name:
- MET7
- Uniprot ID:
- Q08645
- Molecular weight:
- 62150.89844
Reactions
| ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate → ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1). |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP
- Gene Name:
- SAM2
- Uniprot ID:
- P19358
- Molecular weight:
- 42255.5
Reactions
| ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine. |
- General function:
- Involved in pantoate-beta-alanine ligase activity
- Specific function:
- Required for pantothenic acid biosynthesis
- Gene Name:
- PAN6
- Uniprot ID:
- P40459
- Molecular weight:
- 35031.89844
Reactions
| ATP + (R)-pantoate + beta-alanine → AMP + diphosphate + (R)-pantothenate. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1- diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)
- Gene Name:
- PRS4
- Uniprot ID:
- P38063
- Molecular weight:
- 35845.69922
Reactions
| ATP + D-ribose 5-phosphate → AMP + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in dihydropteroate synthase activity
- Specific function:
- Catalyzes three sequential steps of tetrahydrofolate biosynthesis
- Gene Name:
- FOL1
- Uniprot ID:
- P53848
- Molecular weight:
- 93119.10156
Reactions
| 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine → 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. |
| ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine → AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate. |
| (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate → diphosphate + dihydropteroate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
- Gene Name:
- GUS1
- Uniprot ID:
- P46655
- Molecular weight:
- 80842.0
Reactions
| ATP + L-glutamate + tRNA(Glu) → AMP + diphosphate + L-glutamyl-tRNA(Glu). |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes
- Gene Name:
- AIM22
- Uniprot ID:
- P47051
- Molecular weight:
- 47003.0
Reactions
| ATP + lipoate → diphosphate + lipoyl-AMP. |
| Lipoyl-AMP + protein → protein N(6)-(lipoyl)lysine + AMP. |
- General function:
- vacuole inheritance
- Specific function:
- Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole.
- Gene Name:
- VPS15
- Uniprot ID:
- P22219
- Molecular weight:
- 166370.295
Reactions
Transporters
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the sodium or lithium ions to allow salt tolerance. Is negatively modulated by SIS2/HAL3
- Gene Name:
- ENA1
- Uniprot ID:
- P13587
- Molecular weight:
- 120356.0
Reactions
| ATP + H(2)O + Na(+)(In) → ADP + phosphate + Na(+)(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithium ions to allow salt tolerance
- Gene Name:
- ENA5
- Uniprot ID:
- Q12691
- Molecular weight:
- 120295.0
Reactions
| ATP + H(2)O + Na(+)(In) → ADP + phosphate + Na(+)(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithiums ions to allow salt tolerance
- Gene Name:
- ENA2
- Uniprot ID:
- Q01896
- Molecular weight:
- 120316.0
Reactions
| ATP + H(2)O + Na(+)(In) → ADP + phosphate + Na(+)(Out). |
- General function:
- Involved in catalytic activity
- Specific function:
- May be involved in long-chain fatty acids uptake, and thus may play a pivotal role in regulating their accessibility prior to metabolic utilization. May play an important role in uptake of these hydrophobic compounds under conditions where fatty acid synthesis is compromised
- Gene Name:
- FAT1
- Uniprot ID:
- P38225
- Molecular weight:
- 77140.29688
Reactions
- General function:
- Involved in adenine nucleotide transmembrane transporte
- Specific function:
- Adenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen. This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol. Transport of ATP into the peroxisome is required for beta-oxydation of medium-chain fatty acids. Required for growth on medium-chain fatty acids, pH gradient formation in peroxisomes and for normal peroxisome proliferation
- Gene Name:
- ANT1
- Uniprot ID:
- Q06497
- Molecular weight:
- 36367.0
- General function:
- Involved in ATP binding
- Specific function:
- STE6 is required in yeast MATA cells for production of A-factor pheromone. STE6 is involved in the transport of the farnesyl-derivation of the A-factor pheromone
- Gene Name:
- STE6
- Uniprot ID:
- P12866
- Molecular weight:
- 144764.0
Reactions
| ATP + H(2)O + alpha-factor(In) → ADP + phosphate + alpha-factor(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles
- Gene Name:
- CCC2
- Uniprot ID:
- P38995
- Molecular weight:
- 109828.0
Reactions
| ATP + H(2)O + Cu(2+)(In) → ADP + phosphate + Cu(2+)(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Has a role in the secretory pathway
- Gene Name:
- PMR1
- Uniprot ID:
- P13586
- Molecular weight:
- 104570.0
Reactions
| ATP + H(2)O + Ca(2+)(Cis) → ADP + phosphate + Ca(2+)(Trans). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + H(2)O = ADP + phosphate
- Gene Name:
- SPF1
- Uniprot ID:
- P39986
- Molecular weight:
- 135267.0
Reactions
| ATP + H(2)O → ADP + phosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium
- Gene Name:
- PMC1
- Uniprot ID:
- P38929
- Molecular weight:
- 130860.0
Reactions
| ATP + H(2)O + Ca(2+)(Cis) → ADP + phosphate + Ca(2+)(Trans). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential)
- Gene Name:
- DNF3
- Uniprot ID:
- Q12674
- Molecular weight:
- 188318.0
Reactions
| ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. Required for protein transport from Golgi to vacuoles
- Gene Name:
- DNF2
- Uniprot ID:
- Q12675
- Molecular weight:
- 182617.0
Reactions
| ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly
- Gene Name:
- DRS2
- Uniprot ID:
- P39524
- Molecular weight:
- 153843.0
Reactions
| ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential)
- Gene Name:
- DNF1
- Uniprot ID:
- P32660
- Molecular weight:
- 177796.0
Reactions
| ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Probably involved in copper transport and in the regulation of cellular copper level
- Gene Name:
- PCA1
- Uniprot ID:
- P38360
- Molecular weight:
- 131838.0
Reactions
| ATP + H(2)O + Cu(2+)(In) → ADP + phosphate + Cu(2+)(Out). |
| ATP + H2O + Cd2+/in → ADP + phosphate + Cd2+/out |
- General function:
- Involved in nucleotide binding
- Specific function:
- This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes
- Gene Name:
- NEO1
- Uniprot ID:
- P40527
- Molecular weight:
- 130217.0
Reactions
| ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + H(2)O = ADP + phosphate
- Gene Name:
- Not Available
- Uniprot ID:
- Q12697
- Molecular weight:
- 166748.0
Reactions
| ATP + H(2)O → ADP + phosphate. |
- General function:
- Involved in ATP binding
- Specific function:
- Exhibits ATP-dependent bile acid transport
- Gene Name:
- YBT1
- Uniprot ID:
- P32386
- Molecular weight:
- 189160.0
Reactions
- General function:
- Involved in transporter activity
- Specific function:
- Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane
- Gene Name:
- AAC1
- Uniprot ID:
- P04710
- Molecular weight:
- 34120.19922
- General function:
- Involved in transporter activity
- Specific function:
- Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane
- Gene Name:
- AAC3
- Uniprot ID:
- P18238
- Molecular weight:
- 33312.60156
- General function:
- Involved in transporter activity
- Specific function:
- Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane
- Gene Name:
- AAC2
- Uniprot ID:
- P18239
- Molecular weight:
- 34425.89844
- General function:
- Involved in transport
- Specific function:
- Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix
- Gene Name:
- PXA2
- Uniprot ID:
- P34230
- Molecular weight:
- 97125.29688
- General function:
- vacuole inheritance
- Specific function:
- Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole.
- Gene Name:
- VPS15
- Uniprot ID:
- P22219
- Molecular weight:
- 166370.295
Reactions
- General function:
- retrograde transport, endosome to Golgi
- Specific function:
- Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Plays also a role in regulation of filamentous growth.
- Gene Name:
- VPS30
- Uniprot ID:
- Q02948
- Molecular weight:
- 63260.22