You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Yeast Metabolome Database.
Pyrophosphate (YMDB00219)
| Identification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| YMDB ID | YMDB00219 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Name | Pyrophosphate | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Saccharomyces cerevisiae | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strain | Baker's yeast | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | Pyrophosphate, also known as diphosphorsaeure or H4P2O7, belongs to the class of inorganic compounds known as non-metal pyrophosphates. These are inorganic non-metallic compounds containing a pyrophosphate as its largest oxoanion. Pyrophosphate is a moderately acidic compound (based on its pKa). Pyrophosphate exists in all living species, ranging from bacteria to humans. Pyrophosphate is a potentially toxic compound. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Structure |  | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CAS number | 14000-31-8 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Weight | Average: 177.9751 Monoisotopic: 177.943225506 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InChI Key | XPPKVPWEQAFLFU-UHFFFAOYSA-N | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InChI | InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IUPAC Name | (phosphonooxy)phosphonic acid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Traditional IUPAC Name | pyrophosphoric acid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical Formula | H4O7P2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SMILES | OP(O)(=O)OP(O)(O)=O | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical Taxonomy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | belongs to the class of inorganic compounds known as non-metal pyrophosphates. These are inorganic non-metallic compounds containing a pyrophosphate as its largest oxoanion. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kingdom | Inorganic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Super Class | Homogeneous non-metal compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Class | Non-metal oxoanionic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sub Class | Non-metal pyrophosphates | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Direct Parent | Non-metal pyrophosphates | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Alternative Parents | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Substituents |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Framework | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| External Descriptors |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Physical Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| State | Solid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Charge | 0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Melting point | 61 °C | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Predicted Properties |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Biological Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cellular Locations |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Organoleptic Properties | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SMPDB Pathways |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KEGG Pathways |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SMPDB Reactions |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KEGG Reactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Intracellular Concentrations | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Extracellular Concentrations | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spectra |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| References: |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synthesis Reference: | Dittmer, Donald C.; Silverstein, V. Opshelor. Production of pyrophosphate from S-n-butyl phosphorothioate. Journal of Organic Chemistry (1961), 26 4706-7. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| External Links: |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Enzymes
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)
- Gene Name:
- GLN4
- Uniprot ID:
- P13188
- Molecular weight:
- 93132.20313
Reactions
| ATP + L-glutamine + tRNA(Gln) → AMP + diphosphate + L-glutaminyl-tRNA(Gln). |
- General function:
- Involved in catalytic activity
- Specific function:
- ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate
- Gene Name:
- GUA1
- Uniprot ID:
- P38625
- Molecular weight:
- 58481.80078
Reactions
| ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O → AMP + diphosphate + GMP + L-glutamate. |
- General function:
- Involved in asparagine synthase (glutamine-hydrolyzing) activity
- Specific function:
- ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate
- Gene Name:
- ASN1
- Uniprot ID:
- P49089
- Molecular weight:
- 64469.60156
Reactions
| ATP + L-aspartate + L-glutamine + H(2)O → AMP + diphosphate + L-asparagine + L-glutamate. |
- General function:
- Involved in asparagine synthase (glutamine-hydrolyzing) activity
- Specific function:
- ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate
- Gene Name:
- ASN2
- Uniprot ID:
- P49090
- Molecular weight:
- 64592.5
Reactions
| ATP + L-aspartate + L-glutamine + H(2)O → AMP + diphosphate + L-asparagine + L-glutamate. |
- General function:
- Involved in amidophosphoribosyltransferase activity
- Specific function:
- 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O
- Gene Name:
- ADE4
- Uniprot ID:
- P04046
- Molecular weight:
- 56718.89844
Reactions
| 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate → L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O. |
- General function:
- Involved in NAD+ synthase (glutamine-hydrolyzing) activity
- Specific function:
- ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate
- Gene Name:
- QNS1
- Uniprot ID:
- P38795
- Molecular weight:
- 80684.89844
Reactions
| ATP + deamido-NAD(+) + L-glutamine + H(2)O → AMP + diphosphate + NAD(+) + L-glutamate. |
- General function:
- Involved in UDP-glucose:hexose-1-phosphate uridylyltransferase activity
- Specific function:
- UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose
- Gene Name:
- GAL7
- Uniprot ID:
- P08431
- Molecular weight:
- 42384.69922
Reactions
| UDP-glucose + alpha-D-galactose 1-phosphate → alpha-D-glucose 1-phosphate + UDP-galactose. |
- General function:
- Involved in sulfate adenylyltransferase (ATP) activity
- Specific function:
- Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur- containing amino acids
- Gene Name:
- MET3
- Uniprot ID:
- P08536
- Molecular weight:
- 57724.0
Reactions
| ATP + sulfate → diphosphate + adenylyl sulfate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs
- Gene Name:
- GRS1
- Uniprot ID:
- P38088
- Molecular weight:
- 75410.20313
Reactions
| ATP + glycine + tRNA(Gly) → AMP + diphosphate + glycyl-tRNA(Gly). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs
- Gene Name:
- GRS2
- Uniprot ID:
- Q06817
- Molecular weight:
- 71017.89844
Reactions
| ATP + glycine + tRNA(Gly) → AMP + diphosphate + glycyl-tRNA(Gly). |
- General function:
- Involved in phosphorus-oxygen lyase activity
- Specific function:
- Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP
- Gene Name:
- CYR1
- Uniprot ID:
- P08678
- Molecular weight:
- 227832.0
Reactions
| ATP → 3',5'-cyclic AMP + diphosphate. |
- General function:
- Involved in orotate phosphoribosyltransferase activity
- Specific function:
- Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
- Gene Name:
- URA5
- Uniprot ID:
- P13298
- Molecular weight:
- 24664.19922
Reactions
| Orotidine 5'-phosphate + diphosphate → orotate + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in orotate phosphoribosyltransferase activity
- Specific function:
- Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
- Gene Name:
- URA10
- Uniprot ID:
- P30402
- Molecular weight:
- 24810.30078
Reactions
| Orotidine 5'-phosphate + diphosphate → orotate + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
- Gene Name:
- ISM1
- Uniprot ID:
- P48526
- Molecular weight:
- 115793.0
Reactions
| ATP + L-isoleucine + tRNA(Ile) → AMP + diphosphate + L-isoleucyl-tRNA(Ile). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
- Gene Name:
- ILS1
- Uniprot ID:
- P09436
- Molecular weight:
- 122982.0
Reactions
| ATP + L-isoleucine + tRNA(Ile) → AMP + diphosphate + L-isoleucyl-tRNA(Ile). |
- General function:
- Involved in UDP-N-acetylglucosamine diphosphorylase act
- Specific function:
- UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-glucosamine
- Gene Name:
- QRI1
- Uniprot ID:
- P43123
- Molecular weight:
- 53475.60156
Reactions
| UTP + N-acetyl-alpha-D-glucosamine 1-phosphate → diphosphate + UDP-N-acetyl-D-glucosamine. |
- General function:
- Involved in catalytic activity
- Specific function:
- Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Contributes, with FAA1, to the activation of imported myristate
- Gene Name:
- FAA4
- Uniprot ID:
- P47912
- Molecular weight:
- 77266.5
Reactions
| ATP + a long-chain carboxylic acid + CoA → AMP + diphosphate + an acyl-CoA. |
- General function:
- Involved in catalytic activity
- Specific function:
- Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It may supplement intracellular myristoyl-CoA pools from exogenous myristate. Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities
- Gene Name:
- FAA1
- Uniprot ID:
- P30624
- Molecular weight:
- 77865.79688
Reactions
| ATP + a long-chain carboxylic acid + CoA → AMP + diphosphate + an acyl-CoA. |
- General function:
- Involved in catalytic activity
- Specific function:
- Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. This enzyme acts preferentially on C16 and C18 fatty acids with a cis-double bond at C-9-C-10
- Gene Name:
- FAA3
- Uniprot ID:
- P39002
- Molecular weight:
- 77946.0
Reactions
| ATP + a long-chain carboxylic acid + CoA → AMP + diphosphate + an acyl-CoA. |
- General function:
- Involved in acetate-CoA ligase activity
- Specific function:
- Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Aerobic" isozyme of acetyl-coenzyme A synthetase, which supports growth on nonfermentable carbon sources such as glycerol and ethanol. May be required for assimilation of ethanol and acetate
- Gene Name:
- ACS1
- Uniprot ID:
- Q01574
- Molecular weight:
- 79140.10156
Reactions
| ATP + acetate + CoA → AMP + diphosphate + acetyl-CoA. |
- General function:
- Involved in acetate-CoA ligase activity
- Specific function:
- Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Anaerobic" isozyme of acetyl-coenzyme A synthetase, which is required for growth on fermentable carbon sources such as glucose. May be involved in the PDH (pyruvate dehydrogenase complex) bypass
- Gene Name:
- ACS2
- Uniprot ID:
- P52910
- Molecular weight:
- 75491.10156
Reactions
| ATP + acetate + CoA → AMP + diphosphate + acetyl-CoA. |
- General function:
- Involved in catalytic activity
- Specific function:
- Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Preferentially acts on C9:0-C13:0 fatty acids although C7:0-C17:0 fatty acids are tolerated
- Gene Name:
- FAA2
- Uniprot ID:
- P39518
- Molecular weight:
- 83437.10156
Reactions
| ATP + a long-chain carboxylic acid + CoA → AMP + diphosphate + an acyl-CoA. |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Not Available
- Gene Name:
- Not Available
- Uniprot ID:
- P40506
- Molecular weight:
- 41892.69922
Reactions
| CTP + (R)-4'-phosphopantothenate + L-cysteine → CMP + PPi + N-((R)-4'-phosphopantothenoyl)-L-cysteine. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)
- Gene Name:
- Not Available
- Uniprot ID:
- P53852
- Molecular weight:
- 87529.5
Reactions
| ATP + L-cysteine + tRNA(Cys) → AMP + diphosphate + L-cysteinyl-tRNA(Cys). |
- General function:
- Involved in hydrolase activity
- Specific function:
- Coenzyme A diphosphatase which mediates the cleavage of CoA into 3',5'-ADP and 4'-phosphopantetheine. Has a strong preference for oxidized CoA disulfide (CoASSCoA) as substrate. May be required to remove potentially toxic oxidized CoA disulfide to maintain the capacity for beta-oxidation of fatty acids. Can degrade 8-oxo-dGTP in vitro; however, such activity may not be relevant in vivo
- Gene Name:
- PCD1
- Uniprot ID:
- Q12524
- Molecular weight:
- 39754.5
Reactions
| 8-oxo-dGTP + H(2)O → 8-oxo-dGMP + diphosphate. |
- General function:
- Involved in argininosuccinate synthase activity
- Specific function:
- In yeast, as can have a catabolic function since it allows efficient utilization of citrulline via arginine and the reactions involved in the arginase pathway
- Gene Name:
- ARG1
- Uniprot ID:
- P22768
- Molecular weight:
- 46939.30078
Reactions
| ATP + L-citrulline + L-aspartate → AMP + diphosphate + N(omega)-(L-arginino)succinate. |
- General function:
- Involved in anthranilate phosphoribosyltransferase activity
- Specific function:
- N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1- diphosphate
- Gene Name:
- TRP4
- Uniprot ID:
- P07285
- Molecular weight:
- 41374.0
Reactions
| N-(5-phospho-D-ribosyl)-anthranilate + diphosphate → anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Involved in the catabolism of quinolinic acid (QA)
- Gene Name:
- BNA6
- Uniprot ID:
- P43619
- Molecular weight:
- 32364.69922
Reactions
| Nicotinate D-ribonucleotide + diphosphate + CO(2) → pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme
- Gene Name:
- FAD1
- Uniprot ID:
- P38913
- Molecular weight:
- 35545.80078
Reactions
| ATP + FMN → diphosphate + FAD. |
- General function:
- Involved in catalytic activity
- Specific function:
- CTP + choline phosphate = diphosphate + CDP- choline
- Gene Name:
- PCT1
- Uniprot ID:
- P13259
- Molecular weight:
- 49405.80078
Reactions
| CTP + choline phosphate → diphosphate + CDP-choline. |
- General function:
- Involved in ATP binding
- Specific function:
- Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
- Gene Name:
- MOD5
- Uniprot ID:
- P07884
- Molecular weight:
- 50236.19922
Reactions
| Dimethylallyl diphosphate + tRNA → diphosphate + tRNA containing 6-dimethylallyladenosine. |
- General function:
- Involved in isoprenoid biosynthetic process
- Specific function:
- Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate
- Gene Name:
- ERG20
- Uniprot ID:
- P08524
- Molecular weight:
- 40483.0
Reactions
| Dimethylallyl diphosphate + isopentenyl diphosphate → diphosphate + geranyl diphosphate. |
| Geranyl diphosphate + isopentenyl diphosphate → diphosphate + (2E,6E)-farnesyl diphosphate. |
- General function:
- Involved in isoprenoid biosynthetic process
- Specific function:
- Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting
- Gene Name:
- BTS1
- Uniprot ID:
- Q12051
- Molecular weight:
- 38651.0
Reactions
| Dimethylallyl diphosphate + isopentenyl diphosphate → diphosphate + geranyl diphosphate. |
| Geranyl diphosphate + isopentenyl diphosphate → diphosphate + (2E,6E)-farnesyl diphosphate. |
| Trans,trans-farnesyl diphosphate + isopentenyl diphosphate → diphosphate + geranylgeranyl diphosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
- Gene Name:
- AIM10
- Uniprot ID:
- P39965
- Molecular weight:
- 65879.70313
Reactions
| ATP + L-proline + tRNA(Pro) → AMP + diphosphate + L-prolyl-tRNA(Pro). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)
- Gene Name:
- MSR1
- Uniprot ID:
- P38714
- Molecular weight:
- 73693.39844
Reactions
| ATP + L-arginine + tRNA(Arg) → AMP + diphosphate + L-arginyl-tRNA(Arg). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)
- Gene Name:
- MSW1
- Uniprot ID:
- P04803
- Molecular weight:
- 43015.10156
Reactions
| ATP + L-tryptophan + tRNA(Trp) → AMP + diphosphate + L-tryptophyl-tRNA(Trp). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis
- Gene Name:
- Not Available
- Uniprot ID:
- Q05506
- Molecular weight:
- 69524.39844
Reactions
| ATP + L-arginine + tRNA(Arg) → AMP + diphosphate + L-arginyl-tRNA(Arg). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins
- Gene Name:
- MSF1
- Uniprot ID:
- P08425
- Molecular weight:
- 54828.39844
Reactions
| ATP + L-phenylalanine + tRNA(Phe) → AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)
- Gene Name:
- VAS1
- Uniprot ID:
- P07806
- Molecular weight:
- 125769.0
Reactions
| ATP + L-valine + tRNA(Val) → AMP + diphosphate + L-valyl-tRNA(Val). |
- General function:
- Involved in adenine phosphoribosyltransferase activity
- Specific function:
- Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
- Gene Name:
- APT1
- Uniprot ID:
- P49435
- Molecular weight:
- 20586.59961
Reactions
| AMP + diphosphate → adenine + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)
- Gene Name:
- MST1
- Uniprot ID:
- P07236
- Molecular weight:
- 54091.60156
Reactions
| ATP + L-threonine + tRNA(Thr) → AMP + diphosphate + L-threonyl-tRNA(Thr). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
- Gene Name:
- CDC60
- Uniprot ID:
- P26637
- Molecular weight:
- 124140.0
Reactions
| ATP + L-leucine + tRNA(Leu) → AMP + diphosphate + L-leucyl-tRNA(Leu). |
- General function:
- Involved in RNA binding
- Specific function:
- ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)
- Gene Name:
- FRS1
- Uniprot ID:
- P15624
- Molecular weight:
- 67364.29688
Reactions
| ATP + L-phenylalanine + tRNA(Phe) → AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
- General function:
- Involved in biotin-[acetyl-CoA-carboxylase] ligase activity
- Specific function:
- Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase
- Gene Name:
- BPL1
- Uniprot ID:
- P48445
- Molecular weight:
- 76362.39844
Reactions
| ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase] → AMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxytransferase]. |
| ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] → AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]. |
| ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] → AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]. |
| ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] → AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)
- Gene Name:
- FRS2
- Uniprot ID:
- P15625
- Molecular weight:
- 57511.0
Reactions
| ATP + L-phenylalanine + tRNA(Phe) → AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
- Gene Name:
- NAM2
- Uniprot ID:
- P11325
- Molecular weight:
- 101920.0
Reactions
| ATP + L-leucine + tRNA(Leu) → AMP + diphosphate + L-leucyl-tRNA(Leu). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
- Gene Name:
- MSM1
- Uniprot ID:
- P22438
- Molecular weight:
- 66733.89844
Reactions
| ATP + L-methionine + tRNA(Met) → AMP + diphosphate + L-methionyl-tRNA(Met). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)
- Gene Name:
- WRS1
- Uniprot ID:
- Q12109
- Molecular weight:
- 49350.0
Reactions
| ATP + L-tryptophan + tRNA(Trp) → AMP + diphosphate + L-tryptophyl-tRNA(Trp). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)
- Gene Name:
- HTS1
- Uniprot ID:
- P07263
- Molecular weight:
- 59952.0
Reactions
| ATP + L-histidine + tRNA(His) → AMP + diphosphate + L-histidyl-tRNA(His). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
- Gene Name:
- SES1
- Uniprot ID:
- P07284
- Molecular weight:
- 53309.19922
Reactions
| ATP + L-serine + tRNA(Ser) → AMP + diphosphate + L-seryl-tRNA(Ser). |
| ATP + L-serine + tRNA(Sec) → AMP + diphosphate + L-seryl-tRNA(Sec). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
- Gene Name:
- MSE1
- Uniprot ID:
- P48525
- Molecular weight:
- 61602.69922
Reactions
| ATP + L-glutamate + tRNA(Glu) → AMP + diphosphate + L-glutamyl-tRNA(Glu). |
- General function:
- Involved in adenine phosphoribosyltransferase activity
- Specific function:
- Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. May lack catalytic activity
- Gene Name:
- APT2
- Uniprot ID:
- P36973
- Molecular weight:
- 19999.80078
Reactions
| AMP + diphosphate → adenine + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
- Gene Name:
- MES1
- Uniprot ID:
- P00958
- Molecular weight:
- 85677.39844
Reactions
| ATP + L-methionine + tRNA(Met) → AMP + diphosphate + L-methionyl-tRNA(Met). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction:alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain
- Gene Name:
- ALA1
- Uniprot ID:
- P40825
- Molecular weight:
- 107276.0
Reactions
| ATP + L-alanine + tRNA(Ala) → AMP + diphosphate + L-alanyl-tRNA(Ala). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)
- Gene Name:
- SLM5
- Uniprot ID:
- P25345
- Molecular weight:
- 56784.39844
Reactions
| ATP + L-asparagine + tRNA(Asn) → AMP + diphosphate + L-asparaginyl-tRNA(Asn). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
- Gene Name:
- DIA4
- Uniprot ID:
- P38705
- Molecular weight:
- 50389.5
Reactions
| ATP + L-serine + tRNA(Ser) → AMP + diphosphate + L-seryl-tRNA(Ser). |
| ATP + L-serine + tRNA(Sec) → AMP + diphosphate + L-seryl-tRNA(Sec). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
- Gene Name:
- MSY1
- Uniprot ID:
- P48527
- Molecular weight:
- 55286.89844
Reactions
| ATP + L-tyrosine + tRNA(Tyr) → AMP + diphosphate + L-tyrosyl-tRNA(Tyr). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)
- Gene Name:
- MSD1
- Uniprot ID:
- P15179
- Molecular weight:
- 75460.0
Reactions
| ATP + L-aspartate + tRNA(Asp) → AMP + diphosphate + L-aspartyl-tRNA(Asp). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)
- Gene Name:
- MSK1
- Uniprot ID:
- P32048
- Molecular weight:
- 66127.60156
Reactions
| ATP + L-lysine + tRNA(Lys) → AMP + diphosphate + L-lysyl-tRNA(Lys). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)
- Gene Name:
- KRS1
- Uniprot ID:
- P15180
- Molecular weight:
- 67958.0
Reactions
| ATP + L-lysine + tRNA(Lys) → AMP + diphosphate + L-lysyl-tRNA(Lys). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)
- Gene Name:
- DED81
- Uniprot ID:
- P38707
- Molecular weight:
- 62206.30078
Reactions
| ATP + L-asparagine + tRNA(Asn) → AMP + diphosphate + L-asparaginyl-tRNA(Asn). |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
- Gene Name:
- Not Available
- Uniprot ID:
- P38708
- Molecular weight:
- 77385.70313
Reactions
| ATP + L-proline + tRNA(Pro) → AMP + diphosphate + L-prolyl-tRNA(Pro). |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). The specificity determinants on tRNA(Tyr) are the base pair C1-G72, the discriminator residue A73, and the three anticodon bases G34, U35 and A36. Also involved in nuclear tRNA export
- Gene Name:
- TYS1
- Uniprot ID:
- P36421
- Molecular weight:
- 44019.60156
Reactions
| ATP + L-tyrosine + tRNA(Tyr) → AMP + diphosphate + L-tyrosyl-tRNA(Tyr). |
- General function:
- Involved in ligase activity
- Specific function:
- Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha- aminoadipate by NADPH
- Gene Name:
- LYS2
- Uniprot ID:
- P07702
- Molecular weight:
- 155344.0
Reactions
| L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O → L-2-aminoadipate + NAD(P)H. |
- General function:
- Involved in nucleotide binding
- Specific function:
- ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)
- Gene Name:
- THS1
- Uniprot ID:
- P04801
- Molecular weight:
- 84519.79688
Reactions
| ATP + L-threonine + tRNA(Thr) → AMP + diphosphate + L-threonyl-tRNA(Thr). |
- General function:
- Involved in methionine adenosyltransferase activity
- Specific function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP
- Gene Name:
- SAM1
- Uniprot ID:
- P10659
- Molecular weight:
- 41818.0
Reactions
| ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine. |
- General function:
- Involved in nucleotidyltransferase activity
- Specific function:
- ATP + nicotinamide ribonucleotide = diphosphate + NAD(+);ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+
- Gene Name:
- NMA2
- Uniprot ID:
- P53204
- Molecular weight:
- 44908.69922
Reactions
| ATP + nicotinamide ribonucleotide → diphosphate + NAD(+). |
| ATP + nicotinate ribonucleotide → diphosphate + deamido-NAD+ |
- General function:
- Involved in nucleotidyltransferase activity
- Specific function:
- ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)
- Gene Name:
- NMA1
- Uniprot ID:
- Q06178
- Molecular weight:
- 45858.60156
Reactions
| ATP + nicotinamide ribonucleotide → diphosphate + NAD(+). |
- General function:
- Involved in RNA binding
- Specific function:
- This enzyme carries out synthesis of the tRNA CCA terminus without the direction of a template using the multiple accepting and donating subsites within its active site
- Gene Name:
- CCA1
- Uniprot ID:
- P21269
- Molecular weight:
- 62484.39844
Reactions
| A tRNA precursor + 2 CTP + ATP → a tRNA with a 3' CCA end + 3 diphosphate. |
- General function:
- Involved in nucleotidyltransferase activity
- Specific function:
- Not Available
- Gene Name:
- Not Available
- Uniprot ID:
- P53332
- Molecular weight:
- 34306.30078
Reactions
| ATP + pantetheine 4'-phosphate → diphosphate + 3'-dephospho-CoA. |
- General function:
- Involved in acetyl-CoA carboxylase activity
- Specific function:
- Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase
- Gene Name:
- FAS3
- Uniprot ID:
- Q00955
- Molecular weight:
- 250351.0
Reactions
| ATP + acetyl-CoA + HCO(3)(-) → ADP + phosphate + malonyl-CoA. |
| ATP + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein]. |
- General function:
- Involved in ATP phosphoribosyltransferase activity
- Specific function:
- Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity
- Gene Name:
- HIS1
- Uniprot ID:
- P00498
- Molecular weight:
- 32266.09961
Reactions
| 1-(5-phospho-D-ribosyl)-ATP + diphosphate → ATP + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- A phosphate monoester + H(2)O = an alcohol + phosphate
- Gene Name:
- PHO8
- Uniprot ID:
- P11491
- Molecular weight:
- 63003.60156
Reactions
| A phosphate monoester + H(2)O → an alcohol + phosphate. |
| (2E,6E)-farnesyl diphosphate + H(2)O → (2E,6E)-farnesol + diphosphate. |
| beta-D-fructose 2,6-bisphosphate + H2O → beta-D-fructofuranose 2-phosphate + phosphate |
- General function:
- Involved in catalytic activity
- Specific function:
- Essential for thiamine biosynthesis. The kinase activity is involved in the salvage synthesis of TH-P from the thiazole
- Gene Name:
- THI6
- Uniprot ID:
- P41835
- Molecular weight:
- 58058.19922
Reactions
| 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole → diphosphate + thiamine phosphate. |
| ATP + 4-methyl-5-(2-hydroxyethyl)thiazole → ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- 1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5- phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4-carboxamide
- Gene Name:
- HIS4
- Uniprot ID:
- P00815
- Molecular weight:
- 87720.5
Reactions
| 1-(5-phosphoribosyl)-AMP + H(2)O → 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. |
| 1-(5-phosphoribosyl)-ATP + H(2)O → 1-(5-phosphoribosyl)-AMP + diphosphate. |
| L-histidinol + H(2)O + 2 NAD(+) → L-histidine + 2 NADH. |
- General function:
- Involved in catalytic activity
- Specific function:
- CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine
- Gene Name:
- MUQ1
- Uniprot ID:
- P33412
- Molecular weight:
- 36862.60156
Reactions
| CTP + ethanolamine phosphate → diphosphate + CDP-ethanolamine. |
- General function:
- Involved in GTP cyclohydrolase II activity
- Specific function:
- Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
- Gene Name:
- RIB1
- Uniprot ID:
- P38066
- Molecular weight:
- 38331.60156
Reactions
| GTP + 3 H(2)O → formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate. |
- General function:
- Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups
- Specific function:
- Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP)
- Gene Name:
- NUS1
- Uniprot ID:
- Q12063
- Molecular weight:
- 42556.69922
Reactions
| (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate → 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate. |
- General function:
- Involved in nicotinate phosphoribosyltransferase activity
- Specific function:
- Essential for growth under anaerobic conditions
- Gene Name:
- NPT1
- Uniprot ID:
- P39683
- Molecular weight:
- 49018.19922
Reactions
| Nicotinate D-ribonucleotide + diphosphate → nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in isoprenoid biosynthetic process
- Specific function:
- Assembly of polyisoprenoid side chains. The polyprenyl synthase of coenzyme Q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species
- Gene Name:
- COQ1
- Uniprot ID:
- P18900
- Molecular weight:
- 52558.89844
Reactions
- General function:
- Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups
- Specific function:
- Could be a cis-prenyl transferase that adds multiple copies of isopentenyl pyrophosphate (ipp) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (DeDol- PP)
- Gene Name:
- SRT1
- Uniprot ID:
- Q03175
- Molecular weight:
- 40199.69922
Reactions
- General function:
- Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups
- Specific function:
- Cis-prenyl transferase that adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP)
- Gene Name:
- RER2
- Uniprot ID:
- P35196
- Molecular weight:
- 32693.30078
Reactions
- General function:
- Involved in hydrolase activity
- Specific function:
- This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
- Gene Name:
- DUT1
- Uniprot ID:
- P33317
- Molecular weight:
- 15307.2002
Reactions
| dUTP + H(2)O → dUMP + diphosphate. |
- General function:
- Involved in transferase activity
- Specific function:
- Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell- size checkpoint
- Gene Name:
- MPG1
- Uniprot ID:
- P41940
- Molecular weight:
- 39565.60156
Reactions
| GTP + alpha-D-mannose 1-phosphate → diphosphate + GDP-mannose. |
- General function:
- Involved in nucleotidyltransferase activity
- Specific function:
- Plays a central role as a glucosyl donor in cellular metabolic pathways
- Gene Name:
- Not Available
- Uniprot ID:
- P38709
- Molecular weight:
- 55999.80078
Reactions
| UTP + alpha-D-glucose 1-phosphate → diphosphate + UDP-glucose. |
- General function:
- Involved in nucleotidyltransferase activity
- Specific function:
- Plays a central role as a glucosyl donor in cellular metabolic pathways
- Gene Name:
- UGP1
- Uniprot ID:
- P32861
- Molecular weight:
- 55987.39844
Reactions
| UTP + alpha-D-glucose 1-phosphate → diphosphate + UDP-glucose. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Involved in energy production. Its activity is stimulated by uncouplers of ATP synthesis
- Gene Name:
- PPA2
- Uniprot ID:
- P28239
- Molecular weight:
- 35572.39844
Reactions
| Diphosphate + H(2)O → 2 phosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal sequence Cys-Ile-Ile-Leu or Cys-Val-Leu-Leu. Acts, among other substrates, on Rho1 and Rho2 and CDC42 proteins. Participates in a RAS-like C-terminal modification of proteins involved in nuclear division and bud growth. It is involved in bud positioning and cell polarity
- Gene Name:
- CDC43
- Uniprot ID:
- P18898
- Molecular weight:
- 42689.10156
Reactions
| Geranylgeranyl diphosphate + protein-cysteine → S-geranylgeranyl-protein + diphosphate. |
- General function:
- Involved in DNA binding
- Specific function:
- Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome
- Gene Name:
- TY2B-OR1
- Uniprot ID:
- Q12113
- Molecular weight:
- 201982.0
Reactions
| Deoxynucleoside triphosphate + DNA(n) → diphosphate + DNA(n+1). |
- General function:
- Involved in protein prenyltransferase activity
- Specific function:
- Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate
- Gene Name:
- RAM2
- Uniprot ID:
- P29703
- Molecular weight:
- 37507.30078
Reactions
| Farnesyl diphosphate + protein-cysteine → S-farnesyl protein + diphosphate. |
| Geranylgeranyl diphosphate + protein-cysteine → S-geranylgeranyl-protein + diphosphate. |
- General function:
- Involved in transferase activity
- Specific function:
- May regulate the flux of isoprene intermediates through the sterol pathway. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. ERG9 is also essential for cell growth in yeast
- Gene Name:
- ERG9
- Uniprot ID:
- P29704
- Molecular weight:
- 51719.39844
Reactions
| 2 farnesyl diphosphate → diphosphate + presqualene diphosphate. |
| Presqualene diphosphate + NAD(P)H → squalene + diphosphate + NAD(P)(+). |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Diphosphate + H(2)O = 2 phosphate
- Gene Name:
- IPP1
- Uniprot ID:
- P00817
- Molecular weight:
- 32299.30078
Reactions
| Diphosphate + H(2)O → 2 phosphate. |
- General function:
- Involved in prenyltransferase activity
- Specific function:
- Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB
- Gene Name:
- COQ2
- Uniprot ID:
- P32378
- Molecular weight:
- 41001.0
Reactions
| A polyprenyl diphosphate + 4-hydroxybenzoate → diphosphate + a 4-hydroxy-3-polyprenylbenzoate. |
- General function:
- Involved in nucleoside metabolic process
- Specific function:
- IMP + diphosphate = hypoxanthine + 5-phospho- alpha-D-ribose 1-diphosphate
- Gene Name:
- HPT1
- Uniprot ID:
- Q04178
- Molecular weight:
- 25190.5
Reactions
| IMP + diphosphate → hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. |
| GMP + diphosphate → guanine + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4
- Gene Name:
- BET2
- Uniprot ID:
- P20133
- Molecular weight:
- 36665.60156
Reactions
| Geranylgeranyl diphosphate + protein-cysteine → S-geranylgeranyl-protein + diphosphate. |
- General function:
- Involved in transferase activity, transferring phosphorus-containing groups
- Specific function:
- Supplies CDP-diacylglycerol, which may play an important role as both a precursor to phosphoinositide biosynthesis in the plasma membrane and as a negative effector of phosphatidylinositol 4-kinase activity, thereby exerting an effect on cell proliferation via a lipid-dependent signal transduction cascade
- Gene Name:
- CDS1
- Uniprot ID:
- P38221
- Molecular weight:
- 51822.39844
Reactions
| CTP + phosphatidate → diphosphate + CDP-diacylglycerol. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins such as a-factor and RAS. The beta subunit is responsible for peptide-binding
- Gene Name:
- RAM1
- Uniprot ID:
- P22007
- Molecular weight:
- 48189.39844
Reactions
| Farnesyl diphosphate + protein-cysteine → S-farnesyl protein + diphosphate. |
- General function:
- Involved in protoheme IX farnesyltransferase activity
- Specific function:
- Converts protoheme IX and farnesyl diphosphate to heme O
- Gene Name:
- COX10
- Uniprot ID:
- P21592
- Molecular weight:
- 52147.19922
Reactions
- General function:
- Involved in nucleoside metabolic process
- Specific function:
- May act as a xanthine phosphoribosyltransferase involved in the synthesis of purine nucleotides. Such activity is however unclear in vivo
- Gene Name:
- XPT1
- Uniprot ID:
- P47165
- Molecular weight:
- 23671.0
Reactions
- General function:
- Nucleotide transport and metabolism
- Specific function:
- Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
- Gene Name:
- FUR1
- Uniprot ID:
- P18562
- Molecular weight:
- 24594.19922
Reactions
| UMP + diphosphate → uracil + 5-phospho-alpha-D-ribose 1-diphosphate. |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP
- Gene Name:
- SAM2
- Uniprot ID:
- P19358
- Molecular weight:
- 42255.5
Reactions
| ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine. |
- General function:
- Involved in protein prenyltransferase activity
- Specific function:
- Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4
- Gene Name:
- BET4
- Uniprot ID:
- Q00618
- Molecular weight:
- 39674.30078
Reactions
| Geranylgeranyl diphosphate + protein-cysteine → S-geranylgeranyl-protein + diphosphate. |
- General function:
- Involved in pantoate-beta-alanine ligase activity
- Specific function:
- Required for pantothenic acid biosynthesis
- Gene Name:
- PAN6
- Uniprot ID:
- P40459
- Molecular weight:
- 35031.89844
Reactions
| ATP + (R)-pantoate + beta-alanine → AMP + diphosphate + (R)-pantothenate. |
- General function:
- Involved in dihydropteroate synthase activity
- Specific function:
- Catalyzes three sequential steps of tetrahydrofolate biosynthesis
- Gene Name:
- FOL1
- Uniprot ID:
- P53848
- Molecular weight:
- 93119.10156
Reactions
| 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine → 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. |
| ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine → AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate. |
| (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate → diphosphate + dihydropteroate. |
- General function:
- Involved in nucleotide binding
- Specific function:
- Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
- Gene Name:
- GUS1
- Uniprot ID:
- P46655
- Molecular weight:
- 80842.0
Reactions
| ATP + L-glutamate + tRNA(Glu) → AMP + diphosphate + L-glutamyl-tRNA(Glu). |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes
- Gene Name:
- AIM22
- Uniprot ID:
- P47051
- Molecular weight:
- 47003.0
Reactions
| ATP + lipoate → diphosphate + lipoyl-AMP. |
| Lipoyl-AMP + protein → protein N(6)-(lipoyl)lysine + AMP. |
- General function:
- CDP-diacylglycerol biosynthetic process
- Specific function:
- Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.
- Gene Name:
- TAM41
- Uniprot ID:
- P53230
- Molecular weight:
- 44199.33
Reactions
Transporters
- General function:
- Involved in catalytic activity
- Specific function:
- May be involved in long-chain fatty acids uptake, and thus may play a pivotal role in regulating their accessibility prior to metabolic utilization. May play an important role in uptake of these hydrophobic compounds under conditions where fatty acid synthesis is compromised
- Gene Name:
- FAT1
- Uniprot ID:
- P38225
- Molecular weight:
- 77140.29688
Reactions
- General function:
- Involved in DNA binding
- Specific function:
- Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome
- Gene Name:
- TY1B-OL
- Uniprot ID:
- Q12273
- Molecular weight:
- 198613.0
Reactions
| Deoxynucleoside triphosphate + DNA(n) → diphosphate + DNA(n+1). |