{"ymdb_id":"YMDB00483","created_at":"2011-05-29T18:22:31.000Z","updated_at":"2016-09-08T18:35:32.000Z","name":"5,6,7,8-Tetrahydrofolic acid","cas":"135-16-0","state":"Solid","melting_point":"250 oC","description":"Tetrahydrofolate (vitamin B9) and its derivatives, commonly termed folates, are essential cofactors that facilitate the transfer of one-carbon units from donor molecules into important biosynthetic pathways leading to methionine, purine, and pyrimidine biosynthesis. Folates also mediate the interconversion of serine and glycine, and play a role in histidine catabolism. [Biocyc PWY-6613]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"mitochondrion;cytoplasm","synthesis_reference":null,"chebi_id":"20506","hmdb_id":"HMDB01846","kegg_id":"C00101","pubchem_id":"91443","cs_id":"82572","foodb_id":null,"wikipedia_link":"Tetrahydrofolic_acid","biocyc_id":"THF","iupac":"(2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid","traditional_iupac":"tetrahydrofolic acid","logp":"-4.212630310185438","pka":"3.863700981959142","alogps_solubility":"2.69e-01 g/l","alogps_logp":"-0.96","alogps_logs":"-3.22","acceptor_count":"12","donor_count":"8","rotatable_bond_count":"9","polar_surface_area":"207.27000000000004","refractivity":"121.3866","polarizability":"42.9531289011855","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"3.5846826310688993","pka_strongest_acidic":"3.5095693878577654","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["(6s)-tetrahydrofolate","(6s)-tetrahydrofolic acid","(6s)-thfa","5,6,7,8-Tetrahydrofolate","5,6,7,8-tetrahydrofolic acid","folate-H4","H4PteGlu","H4PteGlu1","tetra-H-folate","tetrahydrafolate","Tetrahydrofolate","tetrahydrofolic acid","tetrahydropteroyl mono-L-glutamate","tetrahydropteroylglutamate","th-folate","THF","thf, tetrahydrofolate","vitamin B9"],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"Folate biosynthesis","kegg_map_id":"00790"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null},{"name":"One Carbon Pool by Folate I","kegg_map_id":null},{"name":"purine nucleotides de novo biosynthesis","kegg_map_id":null},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":10799479,"citation":"Cherest, H., Thomas, D., Surdin-Kerjan, Y. (2000). \"Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae.\" J Biol Chem 275:14056-14063."},{"pubmed_id":8852837,"citation":"McNeil, J. B., Bognar, A. L., Pearlman, R. E. (1996). \"In vivo analysis of folate coenzymes and their compartmentation in Saccharomyces cerevisiae.\" Genetics 142:371-381."},{"pubmed_id":16083849,"citation":"Suliman, H. S., Sawyer, G. M., Appling, D. R., Robertus, J. D. (2005). \"Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae.\" Arch Biochem Biophys 441:56-63."},{"pubmed_id":8706696,"citation":"Briza, P., Kalchhauser, H., Pittenauer, E., Allmaier, G., Breitenbach, M. (1996). \"N,N'-Bisformyl dityrosine is an in vivo precursor of the yeast ascospore wall.\" Eur J Biochem 239:124-131."}],"proteins":[{"created_at":"2011-05-24T19:22:02.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"Phosphoribosylglycinamide formyltransferase","uniprot_id":"P04161","uniprot_name":"PUR3_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE8","num_residues":214,"molecular_weight":"23540.0","theoretical_pi":"6.39","general_function":"Involved in hydroxymethyl-, formyl- and related transferase activity","specific_function":"10-formyltetrahydrofolate + N(1)-(5-phospho-D- ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide","reactions":[{"id":1890,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2249,"direction":"\u003e","locations":null,"altext":"10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.","export":false,"pw_reaction_id":null,"source":null},{"id":4151,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006449","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M36585","genbank_protein_id":"171015","gene_card_id":"ADE8","chromosome_location":"chromosome 4","locus":"YDR408C","synonyms":["5'-phosphoribosylglycinamide transformylase","GAR transformylase","GART"],"enzyme_classes":["2.1.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" hydroxymethyl-, formyl- and related transferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphoribosylglycinamide formyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" IMP biosynthetic process"},{"category":"Process","description":" 'de novo' IMP biosynthetic process"}],"pfams":[{"name":"Formyl_trans_N","identifier":"PF00551"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGGCCAGAATTGTCGTATTAATTTCGGGCTCAGGTTCCAACTTGCAAGCCTTGATCGATGCCCAAAAGCAGGGCCAATTAGGCGAGGATGCTCATATTGTCTCTGTCATATCTTCCAGCAAGAAGGCATACGGGTTAACTAGGGCAGCGGACAATAATATCCCCACAAAGGTTTGTTCGCTATACCCATATACAAAGGGTATTGCGAAGGAGGACAAAGCCGCAAGGGCCAAGGCAAGATCCCAGTTTGAGAACGACCTCGCAAAACTAGTGCTCGAGGAAAAGCCTGACGTTATCATCTGCGCGGGCTGGTTATTGATCCTTGGATCTACTTTCTTGAGCCAACTGCAATCTGTGCCGATATTAAATCTGCATCCAGCGCTACCAGGTTGTTTCGATGGTACCACACACGCAATTGAAATGGCATGGCGCAAATGTCAGGACGAGAACAAGCCTCTGACGGCCGGATGCATGGTGCACTATGTCATCGAGGAGGTCGACAAGGGTGAGCCATTGGTGGTAAAAAAGCTAGAAATCATACCTGGCGAAGAAACACTAGAGCAGTACGAGCAAAGGGTACACGATGCTGAGCACATCGCGATTGTAGAAGCTACATATAAGGTTTTACAGCAGCTTCACAAATAA","protein_sequence":"MARIVVLISGSGSNLQALIDAQKQGQLGEDAHIVSVISSSKKAYGLTRAADNNIPTKVCSLYPYTKGIAKEDKAARAKARSQFENDLAKLVLEEKPDVIICAGWLLILGSTFLSQLQSVPILNLHPALPGCFDGTTHAIEMAWRKCQDENKPLTAGCMVHYVIEEVDKGEPLVVKKLEIIPGEETLEQYEQRVHDAEHIAIVEATYKVLQQLHK"},{"created_at":"2011-05-24T20:05:57.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Serine hydroxymethyltransferase, cytosolic","uniprot_id":"P37291","uniprot_name":"GLYC_YEAST","enzyme":true,"transporter":false,"gene_name":"SHM2","num_residues":469,"molecular_weight":"52218.0","theoretical_pi":"7.47","general_function":"Involved in catalytic activity","specific_function":"Interconversion of serine and glycine","reactions":[{"id":1597,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2298,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.","export":false,"pw_reaction_id":null,"source":null},{"id":3844,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006367","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"L22529","genbank_protein_id":"439120","gene_card_id":"SHM2","chromosome_location":"chromosome 12","locus":"YLR058C","synonyms":["SHMT","Glycine hydroxymethyltransferase","Serine methylase"],"enzyme_classes":["2.1.2.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" serine family amino acid metabolic process"},{"category":"Process","description":" glycine metabolic process"},{"category":"Process","description":" L-serine metabolic process"}],"pfams":[{"name":"SHMT","identifier":"PF00464"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cyanoamino acid metabolism","kegg_map_id":"00460"},{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"gene_sequence":"ATGCCTTACACTCTATCCGACGCTCATCATAAGTTGATCACCTCTCATTTGGTGGACACCGACCCTGAAGTGGACTCCATTATCAAGGATGAAATTGAAAGACAAAAGCACTCCATCGATTTGATTGCTTCTGAAAATTTCACCTCAACCTCCGTTTTCGATGCCCTTGGAACTCCATTGTCCAACAAATATTCTGAAGGTTATCCAGGTGCTCGTTACTACGGTGGTAATGAACACATTGACAGAATGGAAATTCTATGTCAACAAAGAGCTTTGAAAGCTTTCCATGTTACTCCAGACAAATGGGGTGTTAACGTCCAAACTTTATCTGGTTCTCCTGCTAACTTGCAAGTTTATCAAGCTATTATGAAGCCTCATGAAAGATTGATGGGTCTATACCTACCAGATGGTGGTCATTTGTCTCACGGTTACGCTACTGAAAACAGAAAAATTTCTGCTGTTTCCACATACTTTGAATCTTTCCCATACAGAGTTAACCCAGAAACCGGTATTATCGACTACGATACTTTAGAAAAGAACGCCATCCTATATAGACCAAAGGTTCTTGTTGCTGGTACTTCAGCATACTGTCGTTTAATTGACTACAAGAGAATGAGAGAAATCGCCGACAAATGTGGTGCTTACTTGATGGTAGACATGGCCCACATTTCTGGTTTGATCGCCGCAGGTGTCATCCCATCTCCTTTCGAATACGCTGATATCGTTACCACCACCACTCACAAGTCTTTGAGAGGTCCACGTGGTGCTATGATTTTCTTCAGAAGAGGTGTGAGATCTATCAACCCTAAGACCGGTAAGGAAGTTCTATACGACTTGGAAAACCCAATTAACTTCTCTGTTTTCCCAGGTCACCAAGGTGGTCCACACAACCATACCATTGCTGCTTTGGCCACTGCTTTGAAGCAAGCTGCCACTCCAGAATTCAAGGAATACCAAACTCAAGTCTTGAAGAATGCTAAGGCTTTGGAAAGTGAATTTAAGAACTTGGGCTACAGATTAGTTTCCAACGGTACCGATTCTCACATGGTTCTAGTATCCTTGAGAGAAAAGGGTGTTGATGGTGCTCGTGTTGAATACATTTGTGAAAAGATTAACATTGCTTTGAACAAAAATTCTATTCCAGGTGACAAATCTGCTTTGGTTCCAGGTGGTGTCCGTATTGGGGCTCCAGCCATGACCACTAGAGGAATGGGTGAAGAAGATTTCCACAGAATTGTTCAATACATTAACAAGGCTGTAGAATTCGCTCAACAAGTTCAACAAAAGCTTCCAAAGGATGCTTGTAGATTAAAGGACTTCAAAGCCAAGGTCGACGAAGGCTCTGATGTTTTGAACACCTGGAAAAAGGAAATTTACGACTGGGCTGGCGAATACCCATTGGCTGTGTAA","protein_sequence":"MPYTLSDAHHKLITSHLVDTDPEVDSIIKDEIERQKHSIDLIASENFTSTSVFDALGTPLSNKYSEGYPGARYYGGNEHIDRMEILCQQRALKAFHVTPDKWGVNVQTLSGSPANLQVYQAIMKPHERLMGLYLPDGGHLSHGYATENRKISAVSTYFESFPYRVNPETGIIDYDTLEKNAILYRPKVLVAGTSAYCRLIDYKRMREIADKCGAYLMVDMAHISGLIAAGVIPSPFEYADIVTTTTHKSLRGPRGAMIFFRRGVRSINPKTGKEVLYDLENPINFSVFPGHQGGPHNHTIAALATALKQAATPEFKEYQTQVLKNAKALESEFKNLGYRLVSNGTDSHMVLVSLREKGVDGARVEYICEKINIALNKNSIPGDKSALVPGGVRIGAPAMTTRGMGEEDFHRIVQYINKAVEFAQQVQQSLPKDACRLKDFKAKVDEGSDVLNTWKKEIYDWAGEYPLAV"},{"created_at":"2011-05-24T20:07:56.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Serine hydroxymethyltransferase, mitochondrial","uniprot_id":"P37292","uniprot_name":"GLYM_YEAST","enzyme":true,"transporter":false,"gene_name":"SHM1","num_residues":490,"molecular_weight":"53686.0","theoretical_pi":"9.05","general_function":"Involved in catalytic activity","specific_function":"Interconversion of serine and glycine","reactions":[{"id":1597,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2298,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.","export":false,"pw_reaction_id":null,"source":null},{"id":3845,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006368","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"L22528","genbank_protein_id":"408368","gene_card_id":"SHM1","chromosome_location":"chromosome 2","locus":"YBR263W","synonyms":["SHMT","Glycine hydroxymethyltransferase","Serine methylase"],"enzyme_classes":["2.1.2.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" serine family amino acid metabolic process"},{"category":"Process","description":" glycine metabolic process"},{"category":"Process","description":" L-serine metabolic process"}],"pfams":[{"name":"SHMT","identifier":"PF00464"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cyanoamino acid metabolism","kegg_map_id":"00460"},{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTTCCCAGAGCTTCTGCATTGGCCAAATGTATGGCAACTGTTCATCGTCGTGGGCTACTCACCAGTGGTGCACAATCGCTAGTCTCCAAACCAGTCTCGGAGGGAGATCCAGAGATGTTTGACATCTTGCAACAAGAACGTCACAGACAAAAACACTCTATCACCCTTATCCCATCAGAAAACTTCACCTCGAAGGCCGTTATGGATTTGTCAGGTTCTGAGCTCCAAAACAAGTATTCTGAAGGTTATCCAGGTGAAAGATACTACGGAGGTAACGAAATCATCGATAAGTCCGAATCCTTGTGTCAAGCAAGAGCTCTGGAACTGTACGGATTAGACCCTGCCAAGTGGGGAGTTAATGTTCAACCATTAAGCGGGGCACCTGCCAATTTGTATGTTTACTCCGCTATCATGAACGTTGGTGAAAGATTAATGGGATTGGATTTGCCAGATGGTGGTCACTTGTCTCACGGGTACCAACTTAAGTCAGGAACGCCAATTTCTTTCATTTCCAAATACTTCCAAAGTATGCCATACCATGTCGACCACACTACGGGGCTAATCGATTACGATAACTTGCAAGTATTGGCCAAGGCATTCAGACCAAAGGTGATCGTGGCCGGTACTTCCGCGTACTCGAGATTAATAGACTACGCTAGATTCAAGGAAATTTCCCAAGGATGCGGCGCATATTTGATGAGTGATATGGCACACATATCCGGTTTGGTGGCAGCCAATGTTGTCCCATCTCCATTTGAACATTCCGATATAGTTACCACAACCACTCACAAGTCCTTGAGAGGCCCAAGAGGTGCTATGATTTTCTTCAGAAAGGGTATCAAGTCTGTCACCAAAAAGGGCAAGGAAATCCCATATGAGTTAGAAAAGAAAATCAACTTCTCAGTTTTCCCAGGACATCAAGGTGGTCCTCACAACCATACTATCGGTGCAATGGCAGTGGCATTAAAGCAAGCGATGTCTCCAGAATTCAAAGAATACCAACAAAAAATTGTCGACAACAGCAAATGGTTTGCTCAGGAACTAACCAAGATGGGTTATAAGTTGGTTTCCGGCGGTACCGATAACCACTTGATTGTTATTGACTTATCCGGTACTCAGGTAGACGGTGCTCGTGTCGAGACAATTTTAAGTGCCTTGAACATTGCTGCTAACAAGAACACCATCCCAGGTGATAAGAGTGCTCTTTTCCCCTCTGGTCTAAGAATCGGTACTCCAGCAATGACCACGAGAGGATTTGGCCGTGAAGAGTTTTCTCAAGTCGCAAAGTACATTGATTCTGCCGTTAAGCTCGCTGAAAATTTGAAAACTTTGGAACCAACAACGAAACTAGATGCAAGATCAAGACTCAATGAGTTCAAGAAGTTGTGTAATGAATCTAGTGAAGTCGCTGCTTTGTCTGGCGAGATTTCCAAGTGGGTCGGTCAATACCCTGTCCCAGGTGATATCTAA","protein_sequence":"MFPRASALAKCMATVHRRGLLTSGAQSLVSKPVSEGDPEMFDILQQERHRQKHSITLIPSENFTSKAVMDLLGSELQNKYSEGYPGERYYGGNEIIDKSESLCQARALELYGLDPAKWGVNVQPLSGAPANLYVYSAIMNVGERLMGLDLPDGGHLSHGYQLKSGTPISFISKYFQSMPYHVDHTTGLIDYDNLQVLAKAFRPKVIVAGTSAYSRLIDYARFKEISQGCGAYLMSDMAHISGLVAANVVPSPFEHSDIVTTTTHKSLRGPRGAMIFFRKGIKSVTKKGKEIPYELEKKINFSVFPGHQGGPHNHTIGAMAVALKQAMSPEFKEYQQKIVDNSKWFAQELTKMGYKLVSGGTDNHLIVIDLSGTQVDGARVETILSALNIAANKNTIPGDKSALFPSGLRIGTPAMTTRGFGREEFSQVAKYIDSAVKLAENLKTLEPTTKLDARSRLNEFKKLCNESSEVAALSGEISKWVGQYPVPGDI"},{"created_at":"2011-05-24T20:14:31.000Z","updated_at":"2011-05-27T14:56:00.000Z","name":"Dihydrolipoyl dehydrogenase, mitochondrial","uniprot_id":"P09624","uniprot_name":"DLDH_YEAST","enzyme":true,"transporter":false,"gene_name":"LPD1","num_residues":499,"molecular_weight":"54009.69922","theoretical_pi":"8.22","general_function":"Involved in oxidoreductase activity","specific_function":"Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine","reactions":[{"id":2306,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1V59","cellular_location":"Mitochondrion matrix","genbank_gene_id":"D50617","genbank_protein_id":"836736","gene_card_id":"LPD1","chromosome_location":"chromosome 6","locus":"YFL018C","synonyms":["Dihydrolipoamide dehydrogenase","Glycine decarboxylase complex subunit L","Lipoamide dehydrogenase component of pyruvate dehydrogenase complex","Pyruvate dehydrogenase complex E3 component"],"enzyme_classes":["1.8.1.4"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on NADH or NADPH"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" dihydrolipoyl dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cell redox homeostasis"}],"pfams":[{"name":"Pyr_redox","identifier":"PF00070"},{"name":"Pyr_redox_2","identifier":"PF07992"},{"name":"Pyr_redox_dim","identifier":"PF02852"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"}],"gene_sequence":"ATGTTAAGAATCAGATCACTCCTAAATAATAAGCGTGCCTTTTCGTCCACAGTCAGGACATTGACCATTAACAAGTCACATGATGTAGTCATCATCGGTGGTGGCCCTGCTGGTTACGTGGCTGCTATCAAAGCTGCTCAATTGGGATTTAACACTGCATGTGTAGAAAAAAGAGGCAAATTAGGCGGTACCTGTCTTAACGTTGGATGTATCCCCTCCAAAGCACTTCTAAATAATTCTCATTTATTCCACCAAATGCATACGGAAGCGCAAAAGAGAGGTATTGACGTCAACGGTGATATCAAAATTAACGTAGCAAACTTCCAAAAGGCTAAGGATGACGCTGTTAAGCAATTAACTGGAGGTATTGAGCTTCTGTTCAAGAAAAATAAGGTCACCTATTATAAAGGTAATGGTTCATTCGAAGACGAAACGAAGATCAGAGTAACTCCCGTTGATGGGTTGGAAGGCACTGTCAAGGAAGACCACATACTAGATGTTAAGAACATCATAGTCGCCACGGGCTCTGAAGTTACACCCTTCCCCGGTATTGAAATAGATGAGGAAAAAATTGTCTCTTCAACAGGTGCTCTTTCGTTAAAGGAAATTCCCAAAAGATTAACCATCATTGGTGGAGGAATCATCGGATTGGAAATGGGTTCAGTTTACTCTAGATTAGGCTCCAAGGTTACTGTAGTAGAATTTCAACCTCAAATTGGTGCATCTATGGACGGCGAGGTTGCCAAAGCCACCCAAAAGTTCTTGAAAAAGCAAGGTTTGGACTTCAAATTAAGCACCAAAGTTATTTCTGCAAAGAGAAACGACGACAAGAACGTCGTCGAAATTGTTGTAGAAGATACTAAAACGAATAAGCAAGAAAATTTGGAAGCTGAAGTTTTGCTGGTTGCTGTTGGTAGAAGACCTTACATTGCTGGCTTAGGGGCTGAAAAGATTGGATTAGAAGTAGACAAAAGGGGACGCCTAGTCATTGATGACCAATTTAATTCCAAGTTCCCACACATTAAAGTGGTAGGAGATGTTACATTTGGTCCAATGCTGGCTCACAAAGCCGAAGAGGAAGGTATTGCAGCTGTCGAAATGTTGAAAACTGGTCACGGTCATGTCAACTATAACAACATTCCTTCGGTCATGTATTCTCACCCAGAAGTAGCATGGGTTGGTAAAACCGAAGAGCAATTGAAAGAAGCCGGCATTGACTATAAAATTGGTAAGTTCCCCTTTGCGGCCAATTCAAGAGCCAAGACCAACCAAGACACTGAAGGTTTCGTGAAGATTTTGATCGATTCCAAGACCGAGCGTATTTTGGGGGCTCACATTATCGGTCCAAATGCCGGTGAAATGATTGCTGAAGCTGGCTTAGCCTTAGAATATGGCGCTTCCGCAGAAGATGTTGCTAGGGTCTGCCATGCTCATCCTACTTTGTCCGAAGCATTTAAGGAAGCTAACATGGCTGCCTATGATAAAGCTATTCATTGTTGA","protein_sequence":"MLRIRSLLNNKRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC"},{"created_at":"2011-05-26T17:49:27.000Z","updated_at":"2011-07-22T17:54:37.000Z","name":"Dihydrofolate reductase","uniprot_id":"P07807","uniprot_name":"DYR_YEAST","enzyme":true,"transporter":false,"gene_name":"DFR1","num_residues":211,"molecular_weight":"24260.80078","theoretical_pi":"8.05","general_function":"Involved in dihydrofolate reductase activity","specific_function":"Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis","reactions":[{"id":1455,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2485,"direction":"\u003e","locations":null,"altext":"5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":4147,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006448","source":"Smpdb"},{"id":4148,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006675","source":"Smpdb"},{"id":4149,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006676","source":"Smpdb"},{"id":4150,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006677","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M18578","genbank_protein_id":"171397","gene_card_id":"DFR1","chromosome_location":"chromosome 15","locus":"YOR236W","synonyms":[],"enzyme_classes":["1.5.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" NADP or NADPH binding"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" dihydrofolate reductase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide biosynthetic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" glycine biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" serine family amino acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glycine metabolic process"}],"pfams":[{"name":"DHFR_1","identifier":"PF00186"}],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"Folate biosynthesis","kegg_map_id":"00790"},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGGCTGGAGGAAAGATTCCTATTGTAGGAATTGTGGCATGTTTACAGCCGGAGATGGGGATAGGATTTCGTGGAGGTCTACCATGGAGGTTGCCCAGTGAAATGAAGTATTTCAGACAGGTCACTTCATTGACGAAAGATCCAAACAAAAAAAATGCTTTGATAATGGGAAGGAAGACATGGGAATCCATACCGCCCAAGTTTCGCCCACTGCCCAATAGAATGAATGTCATTATATCGAGAAGCTTCAAGGACGATTTTGTCCACGATAAAGAGAGATCAATAGTCCAAAGTAATTCATTGGCAAACGCAATAATGAACCTAGAAAGCAATTTTAAGGAGCATCTGGAAAGAATCTACGTGATTGGGGGTGGCGAAGTTTATAGTCAAATCTTCTCCATTACAGATCATTGGCTCATCACGAAAATAAATCCATTAGATAAAAACGCAACTCCTGCAATGGACACTTTCCTTGATGCGAAGAAATTGGAAGAAGTATTTAGCGAGCAAGATCCGGCCCAGCTGAAAGAATTTCTTCCCCCTAAAGTAGAGTTGCCCGAAACAGACTGTGATCAACGCTACTCGCTGGAAGAAAAAGGTTATTGCTTCGAATTCACTCTATACAATCGTAAATGA","protein_sequence":"MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK"},{"created_at":"2011-05-26T17:51:31.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"C-1-tetrahydrofolate synthase, mitochondrial","uniprot_id":"P09440","uniprot_name":"C1TM_YEAST","enzyme":true,"transporter":false,"gene_name":"MIS1","num_residues":975,"molecular_weight":"106216.0","theoretical_pi":"9.02","general_function":"Involved in formate-tetrahydrofolate ligase activity","specific_function":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH","reactions":[{"id":1548,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1727,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1733,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2488,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2489,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":2490,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":3849,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006370","source":"Smpdb"},{"id":3850,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006371","source":"Smpdb"},{"id":3851,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006372","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"J03724","genbank_protein_id":"171953","gene_card_id":"MIS1","chromosome_location":"chromosome 2","locus":"YBR084W","synonyms":["C1-THF synthase","Methylenetetrahydrofolate dehydrogenase","Methenyltetrahydrofolate cyclohydrolase","Formyltetrahydrofolate synthetase"],"enzyme_classes":["1.5.1.5","3.5.4.9","6.3.4.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" formate-tetrahydrofolate ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FTHFS","identifier":"PF01268"},{"name":"THF_DHG_CYH","identifier":"PF00763"},{"name":"THF_DHG_CYH_C","identifier":"PF02882"}],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"glycine metabolism","kegg_map_id":null},{"name":"serine metabolism","kegg_map_id":null},{"name":"tetrahydrofolate biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTTGTCGAGACTATCTTTATTGAGTAACTCGAGGGCGTTCCAACAGGCCAGATGGCGCATTTACCGCTTAAAAGTTTCGCCAACTGTGCATGCTTCTCAATACCATATTCTTTCTGGTAGGAAACTTGCTCAATCTATTCGAGAAAAAGCCAATGATGAGATACAAGCCATTAAGCTTAAGCATCCTAATTTCAAGCCTACCTTGAAAATCATTCAAGTCGGGGCCAGACCAGACTCATCTACGTACGTGAGGATGAAATTGAAAGCTTCAAAGGACAGCAATGTAGACTGTATCATAGAGAAGTTACCAGCAGAAATCACTGAAGTTGAGCTTTTGAAGAAAATTAGTGACATCAATGATGATGACTCTATCCATGGGTTGCTAATTCAACTACCTCTACCGCGTCACTTGGATGAAACCACGATTACAAACGCTGTGGACTTTAAAAAGGACGTTGATGGGTTCCACAGATATAATGCTGGTGAATTGGCTAAAAAAGGAGGGAAACCATACTTCATACCATGTACTCCTTATGGTTGCATGAAATTACTTGAAGAAGCTCATGTTAAGTTAGATGGTAAGAACGCCGTCGTGTTAGGCAGATCAAGTATCGTCGGAAATCCAATTGCTTCGTTGTTGAAAAATGCGAATGCCACTGTTACTGTCTGTCATAGTCATACAAGGAACATTGCAGAAGTGGTCTCCCAAGCTGATATAGTTATCGCAGCTTGCGGTATTCCTCAATACGTTAAATCAGACTGGATTAAAGAAGGCGCCGTGGTTATTGATGTAGGTATCAACTACGTACCTGATATCAGTAAGAAAAGTGGGCAAAAATTAGTTGGTGATGTTGATTTTGATTCTGTAAAGGAAAAGACATCTTATATTACCCCTGTTCCTGGTGGAGTGGGTCCAATGACTGTCGCTATGCTTGTTTCCAATGTACTATTAGCTGCTAAAAGGCAATTCGTGGAATCTGAAAAGCTTCCAGTTATCAAACCTCTTCCATTACACTTAGAAAGTCCAGTGCCTTCAGATATTGATATATCAAGAGCTCAGAGTCCTAAGCATATCAAGCAAGTTGCCGAGGAGTTGGGAATCCACTCTCACGAATTAGAATTATACGGCCACTATAAGGCAAAAATTTCTCCAAATATTTTTAAAAGATTAGAATCTAGAGAAAACGGTAAGTACGTCCTTGTTGCAGGTATTACTCCGACTCCATTGGGTGAAGGTAAATCCACTACGACTATGGGGTTGGTGCAGGCTTTATCCGCTCATTTAGGGAAACCATCCATCGCGAACGTTAGACAACCATCTCTTGGCCCAACCCTGGGTGTCAAAGGTGGTGCTGCTGGTGGTGGTTATGCCCAAGTTATTCCTATGGACGAGTTCAATTTACATTTGACCGGGGATATTCATGCTATCAGCGCTGCGAACAATCTTCTTGCAGCAGCTATCGACACTAGAATGTTCCATGAAGCCACTCAGAAGAATGATAGTACATTTTACAAGAGACTAGTTCCAAGAAAAAAAGGCATCAGAAAGTTTACCCCATCCATGCAGAGAAGGCTTAAAAGATTGGATATTGAAAAAGAAGACCCTGATGCTTTAACACCTGAAGAAGTCAAAAGATTTGCTAGATTGAACATAAATCCCGATACTATCACTATCAGAAGAGTTGTCGACATCAATGACAGGATGTTAAGACAAATTACCATTGGCGAAGCCGCTACGGAGAAGGGTTTTACAAGGACCACTGGATTCGATATCACTGTTGCCTCTGAATTAATGGCCATTTTAGCTCTATCTAAAAGCTTACACGAGATGAAGGAACGTATTGGACGCATGGTTATTGGTGCTGATTATGATAACAAACCAGTAACAGTAGAAGATATTGGCTGTACCGGTGCTCTGACTGCATTATTACGTGACGCTATAAAGCCTAACTTAATGCAAACTTTGGAAGGGACCCCCGTAATGGTTCACGCTGGTCCTTTCGCCAACATCTCCATCGGCGCATCATCAGTAATTGCAGACTTAATGGCATTGAAGCTTGTTGGTTCAGAAAAGAACCCGTTAAATGACAAGAACATCCATGAACCTGGTTATGTAGTTACTGAAGCAGGATTCGATTTTGCCATGGGTGGTGAAAGATTCTTTGATATCAAATGTCGTTCCTCTGGATTGGTGCCAGATGCAGTTGTCTTAGTCGCAACCGTAAGAGCTTTGAAATCTCATGGAGGTGCTCCAAATGTTAAGCCCGGACAATCATTACCAAAAGAATACACAGAGGAAAACATCGATTTTGTTGCCAAGGGTGTTAGTAATTTGGTTAAGCAGATTGAAAACATCAAAACGTTTGGAATACCAGTCGTTGTAGCAATCAACAGATTTGAAACAGACTCACAGGCAGAGATTGAGGTAATCAAGAAAGCAGCCTTGAATGCTGGCGCATCTCATGCCGTTACTTCTAATCACTGGATGGAAGGTGGTAAAGGTGCAGTAGAATTAGCACATGCTGTGGTAGATGCAACGAAAGAACCAAAGAACTTTAACTTTTTGTACGACGTCAATAGCTCCATCGAGGACAAGCTTACCAGCATCGTCCAAAAAATGTATGGTGGGGCAAAAATCGAAGTATCACCAGAAGCCCAAAAAAAGATAGACACCTACAAAAAACAAGGCTTCGGTAATCTTCCCATCTGTATTGCTAAGACACAATATTCATTATCCCATGATCCATCATTAAAGGGTGTTCCTAGAGGTTTTACGTTCCCCATCAGGGATGTGAGAGCTTCAATAGGTGCAGGTTATTTATACGCTTTGGCTGCAGAAATTCAAACCATACCGGGTCTATCGACATATGCTGGTTACATGGCAGTAGAAGTCGACGACGACGGTGAAATTGAAGGTCTATTTTAA","protein_sequence":"MLSRLSLLSNSRAFQQARWRIYRLKVSPTVHASQYHILSGRKLAQSIREKANDEIQAIKLKHPNFKPTLKIIQVGARPDSSTYVRMKLKASKDSNVDCIIEKLPAEITEVELLKKISDINDDDSIHGLLIQLPLPRHLDETTITNAVDFKKDVDGFHRYNAGELAKKGGKPYFIPCTPYGCMKLLEEAHVKLDGKNAVVLGRSSIVGNPIASLLKNANATVTVCHSHTRNIAEVVSQADIVIAACGIPQYVKSDWIKEGAVVIDVGINYVPDISKKSGQKLVGDVDFDSVKEKTSYITPVPGGVGPMTVAMLVSNVLLAAKRQFVESEKLPVIKPLPLHLESPVPSDIDISRAQSPKHIKQVAEELGIHSHELELYGHYKAKISPNIFKRLESRENGKYVLVAGITPTPLGEGKSTTTMGLVQALSAHLGKPSIANVRQPSLGPTLGVKGGAAGGGYAQVIPMDEFNLHLTGDIHAISAANNLLAAAIDTRMFHEATQKNDSTFYKRLVPRKKGIRKFTPSMQRRLKRLDIEKEDPDALTPEEVKRFARLNINPDTITIRRVVDINDRMLRQITIGEAATEKGFTRTTGFDITVASELMAILALSKSLHEMKERIGRMVIGADYDNKPVTVEDIGCTGALTALLRDAIKPNLMQTLEGTPVMVHAGPFANISIGASSVIADLMALKLVGSEKNPLNDKNIHEPGYVVTEAGFDFAMGGERFFDIKCRSSGLVPDAVVLVATVRALKSHGGAPNVKPGQSLPKEYTEENIDFVAKGVSNLVKQIENIKTFGIPVVVAINRFETDSQAEIEVIKKAALNAGASHAVTSNHWMEGGKGAVELAHAVVDATKEPKNFNFLYDVNSSIEDKLTSIVQKMYGGAKIEVSPEAQKKIDTYKKQGFGNLPICIAKTQYSLSHDPSLKGVPRGFTFPIRDVRASIGAGYLYALAAEIQTIPGLSTYAGYMAVEVDDDGEIEGLF"},{"created_at":"2011-05-26T17:52:10.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Bifunctional purine biosynthesis protein ADE17","uniprot_id":"P38009","uniprot_name":"PUR92_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE17","num_residues":592,"molecular_weight":"65262.60156","theoretical_pi":"6.52","general_function":"Involved in IMP cyclohydrolase activity","specific_function":"10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide","reactions":[{"id":1655,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1886,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2491,"direction":"\u003e","locations":"Cytoplasmic","altext":"10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null},{"id":2492,"direction":"\u003e","locations":"Cytoplasmic","altext":"IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null},{"id":14239,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006682","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"Z49273","genbank_protein_id":"809579","gene_card_id":"ADE17","chromosome_location":"chromosome 13","locus":"YMR120C","synonyms":["Phosphoribosylaminoimidazolecarboxamide formyltransferase","5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase","AICAR transformylase","IMP cyclohydrolase","ATIC","IMP synthase","Inosinicase"],"enzyme_classes":["2.1.2.3","3.5.4.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydroxymethyl-, formyl- and related transferase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"},{"category":"Function","description":" phosphoribosylaminoimidazolecarboxamide formyltransferase activity"},{"category":"Function","description":" cyclohydrolase activity"},{"category":"Function","description":" IMP cyclohydrolase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" IMP biosynthetic process"}],"pfams":[{"name":"MGS","identifier":"PF02142"},{"name":"AICARFT_IMPCHas","identifier":"PF01808"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"One Carbon Pool by Folate I","kegg_map_id":null}],"gene_sequence":"ATGGCCAATTACACAAAAACCGCAATCCTATCCGTCTATGACAAGACAGGTCTACTTGATTTAGCCAGAGGCCTCATCGAGAAGAACGTTCGTATTCTCGCCTCCGGTGGTACTGCTCGTATGATTCGTGACGCTGGTTTTCCAATCGAAGACGTTTCTGCTATCACACATGCCCCAGAAATGTTGGGAGGTAGAGTGAAAACTTTACATCCTGCCGTTCATGGTGGTATCCTTGCTAGGGACATCGATAGCGATGAGAAAGACTTGAAGGAACAGCACATTGAAAAAGTCGATTATGTCGTTTGTAACCTATACCCATTCAAAGAAACTGTTGCTAAGGTGGGTGTGACTATTCCAGAAGCAGTAGAAGAAATTGATATTGGTGGTGTTACTCTATTAAGAGCAGCTGCTAAGAACCATGCTAGAGTCACTATTTTATCTGATCCAAAGGACTACTCCGAATTTTTAAGTGAATTATCCAGTAATGGTGAAATCTCTCAAGATTTGAGAAACAGATTGGCATTAAAGGCTTTCGAACACACTGCCGATTATGATGCTGCAATTTCAGATTTCTTCAGGAAACAATACTCTGAAGGTCAAGCTCAAATTACTCTACGTTATGGTGCCAATCCACACCAAAAGCCGGCTCAAGCTTACGTCAGTCAACAAGACAGTTTACCTTTCAAAGTCCTATGTGGTTCACCAGGTTACATTAATTTGTTGGATGCTCTAAATTCCTGGCCCCTGGTTAAGGAATTATCCGCCTCGTTGAATTTACCAGCAGCAGCATCGTTCAAGCATGTATCACCAGCTGGTGCCGCTGTGGGTATCCCATTGTCTGATGTTGAAAAGCAAGTTTATTTTGTTGCCGACATTGAAAACTTATCTCCCCTGGCATGTGCCTATGCTAGGGCCCGTGGTGCTGATAGAATGTCTTCCTTTGGTGATTGGATTGCTCTTTCCAACATAGTTGATGTTCCAACAGCTAAGATCATATCTAGAGAAGTTTCTGATGGTGTTATTGCCCCAGGTTATGAGCCTGAGGCGTTGGCCATTCTATCCAAGAAGAAGGGAGGTAAGTACTGCATATTACAAATTGATCCAAACTATGTTCCAGAAGCTGTCGAAAGAAGACAAGTATACGGTGTGACTTTGGAACAAAAGAGAAACGATGCCATAATCAATCAATCAACTTTCAAAGAAATTGTTTCTCAAAATAAAAATCTCACTGAACAAGCCATAATTGATTTAACGGTTGCCACCATTGCTATTAAATATACTCAATCTAATTCCGTATGTTATGCTAGAAATGGTATGGTTGTCGGATTGGGTGCAGGTCAACAATCTAGAATCCATTGTACAAGATTAGCTGGTGATAAGGCTGATAATTGGTGGTTCAGACAACACCCTAGAGTTTTGGAGATTAAATGGGCTAAAGGCGTCAAGAGACCAGAAAAATCTAATGCTATCGATTTATTCGTAACCGGCCAAATTCCAACAGAAGAACCAGAATTGTCTGAATACCAATCGAAGTTCGAGGAGATTCCAAAACCATTTACTCCAGAAGAAAGAAAGGAATGGTTGAGTAAATTAACCAACGTTTCTTTGTCATCGGATGCATTTTTCCCATTCCCAGACAATGTTTACAGAGCAGTTAAATCCGGTGTCAAATACATTGCCGCTCCATCTGGTTCTGTCATGGACAAGGTTGTATTTTCAGCTGCCGATTCATTCGATTTGGTTTACGTAGAGAACCCAATCCGTTTGTTCCACCATTAG","protein_sequence":"MANYTKTAILSVYDKTGLLDLARGLIEKNVRILASGGTARMIRDAGFPIEDVSAITHAPEMLGGRVKTLHPAVHGGILARDIDSDEKDLKEQHIEKVDYVVCNLYPFKETVAKVGVTIPEAVEEIDIGGVTLLRAAAKNHARVTILSDPKDYSEFLSELSSNGEISQDLRNRLALKAFEHTADYDAAISDFFRKQYSEGQAQITLRYGANPHQKPAQAYVSQQDSLPFKVLCGSPGYINLLDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVGIPLSDVEKQVYFVADIENLSPLACAYARARGADRMSSFGDWIALSNIVDVPTAKIISREVSDGVIAPGYEPEALAILSKKKGGKYCILQIDPNYVPEAVERRQVYGVTLEQKRNDAIINQSTFKEIVSQNKNLTEQAIIDLTVATIAIKYTQSNSVCYARNGMVVGLGAGQQSRIHCTRLAGDKADNWWFRQHPRVLEIKWAKGVKRPEKSNAIDLFVTGQIPTEEPELSEYQSKFEEIPKPFTPEERKEWLSKLTNVSLSSDAFFPFPDNVYRAVKSGVKYIAAPSGSVMDKVVFSAADSFDLVYVENPIRLFHH"},{"created_at":"2011-05-26T17:52:41.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Bifunctional purine biosynthesis protein ADE16","uniprot_id":"P54113","uniprot_name":"PUR91_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE16","num_residues":591,"molecular_weight":"65281.80078","theoretical_pi":"6.52","general_function":"Involved in IMP cyclohydrolase activity","specific_function":"10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide","reactions":[{"id":1655,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1886,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2491,"direction":"\u003e","locations":"Cytoplasmic","altext":"10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null},{"id":2492,"direction":"\u003e","locations":"Cytoplasmic","altext":"IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"U62402","genbank_protein_id":"1480728","gene_card_id":"ADE16","chromosome_location":"chromosome 12","locus":"YLR028C","synonyms":["Phosphoribosylaminoimidazolecarboxamide formyltransferase","5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase","AICAR transformylase","IMP cyclohydrolase","ATIC","IMP synthase","Inosinicase"],"enzyme_classes":["2.1.2.3","3.5.4.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydroxymethyl-, formyl- and related transferase activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"},{"category":"Function","description":" phosphoribosylaminoimidazolecarboxamide formyltransferase activity"},{"category":"Function","description":" cyclohydrolase activity"},{"category":"Function","description":" IMP cyclohydrolase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" IMP biosynthetic process"}],"pfams":[{"name":"MGS","identifier":"PF02142"},{"name":"AICARFT_IMPCHas","identifier":"PF01808"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGGGCAAATATACCAAGACTGCGATCTTGTCAGTTTATGATAAGACAGGTTTATTAGACTTAGCCAAGGGATTGGTAGAGAACAATGTTCGTATCCTAGCATCCGGTGGTACGGCCAACATGGTCAGAGAAGCTGGTTTTCCGGTCGACGATGTTTCTTCAATTACGCATGCACCAGAAATGCTAGGGGGTAGAGTCAAGACTCTTCACCCTGCTGTGCATGCAGGTATTCTTGCCAGAAATTTAGAGGGCGATGAAAAAGATTTAAAAGAGCAGCACATTGATAAGGTGGATTTTGTTGTATGTAATCTATATCCGTTCAAAGAAACTGTGGCTAAAATTGGTGTTACAGTTCAAGAAGCTGTAGAGGAGATCGACATTGGCGGTGTGACTTTGTTGAGAGCAGCCGCAAAGAACCATTCCAGAGTGACTATTCTTTCAGACCCTAATGACTATTCTATCTTTCTGCAAGACCTGTCTAAGGACGGTGAAATTTCTCAGGATTTAAGAAATAGATTTGCACTTAAGGCGTTTGAACATACGGCCGATTATGATGCGGCCATTTCTGACTTTTTCAGGAAACAGTACTCCGAAGGGAAAGCCCAATTACCGCTAAGATATGGTTGTAATCCCCACCAAAGACCTGCACAAGCTTATATCACTCAGCAGGAGGAGTTGCCCTTCAAAGTGCTCTGCGGTACACCAGGATATATAAATCTTTTGGATGCCTTGAACTCATGGCCCTTAGTGAAAGAGTTATCTGCATCATTGAACTTGCCTGCGGCAGCATCGTTCAAGCACGTTTCTCCAGCAGGTGCTGCTGTGGGACTTCCATTATCCGATGTGGAAAGACAAGTTTATTTTGTGAATGATATGGAGGATTTATCACCATTGGCATGCGCATACGCTAGGGCCCGTGGTGCAGATAGGATGTCATCCTTTGGTGATTTCATTGCATTGTCCAATATTGTAGATGTCGCCACTGCAAAAATCATCTCTAAAGAAGTTTCCGATGGTGTTATTGCTCCAGGGTATGAACCAGAGGCATTGAATATACTATCTAAGAAGAAAAACGGAAAATACTGTATTTTACAAATCGATCCAAACTATGTTCCTGGCCAAATGGAATCCCGAGAGGTTTTTGGCGTAACGTTACAACAGAAGAGAAACGATGCGATCATAAACCAATCCACTTTCAAAGAAATTGTCTCCAAAAACAAAGCACTCACCGAGCAAGCCGTTATCGATCTAACTGTTGCTACGCTGGTTTTAAAATACACACAATCAAATTCTGTTTGCTACGCAAAGAATGGTATGGTTGTGGGGCTTGGGGCCGGCCAACAATCGCGTATACACTGTACCAGATTAGCTGGTGACAAGACGGACAACTGGTGGTTGAGACAACATCCAAAGGTTTTGAACATGAAGTGGGCCAAGGGAATTAAGAGAGCGGACAAGTCGAATGCGATTGATCTTTTTGTTACAGGGCAAAGAATAGAAGGCCCGGAAAAGGTGGATTACGAAAGCAAATTTGAAGAAGTCCCTGAACCTTTCACCAAAGAAGAAAGACTAGAATGGTTAAGCAAATTAAACAATGTATCGTTATCATCCGATGCGTTCTTTCCCTTCCCAGACAACGTTTATAGAGCTGTGCAGTCTGGTGTAAAGTTCATCACGGCTCCTTCGGGGTCTGTCATGGACAAAGTTGTCTTCCAAGCGGCGGATTCATTTGATATCGTCTACGTGGAGAACCCAATTCGTTTATTCCACCACTAA","protein_sequence":"MGKYTKTAILSVYDKTGLLDLAKGLVENNVRILASGGTANMVREAGFPVDDVSSITHAPEMLGGRVKTLHPAVHAGILARNLEGDEKDLKEQHIDKVDFVVCNLYPFKETVAKIGVTVQEAVEEIDIGGVTLLRAAAKNHSRVTILSDPNDYSIFLQDLSKDGEISQDLRNRFALKAFEHTADYDAAISDFFRKQYSEGKAQLPLRYGCNPHQRPAQAYITQQEELPFKVLCGTPGYINLLDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVGLPLSDVERQVYFVNDMEDLSPLACAYARARGADRMSSFGDFIALSNIVDVATAKIISKEVSDGVIAPGYEPEALNILSKKKNGKYCILQIDPNYVPGQMESREVFGVTLQQKRNDAIINQSTFKEIVSKNKALTEQAVIDLTVATLVLKYTQSNSVCYAKNGMVVGLGAGQQSRIHCTRLAGDKTDNWWLRQHPKVLNMKWAKGIKRADKSNAIDLFVTGQRIEGPEKVDYESKFEEVPEPFTKEERLEWLSKLNNVSLSSDAFFPFPDNVYRAVQSGVKFITAPSGSVMDKVVFQAADSFDIVYVENPIRLFHH"},{"created_at":"2011-05-26T17:53:12.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Methionyl-tRNA formyltransferase, mitochondrial","uniprot_id":"P32785","uniprot_name":"FMT_YEAST","enzyme":true,"transporter":false,"gene_name":"FMT1","num_residues":401,"molecular_weight":"44616.19922","theoretical_pi":"10.18","general_function":"Involved in methionyl-tRNA formyltransferase activity","specific_function":"Formylates methionyl-tRNA in mitochondria","reactions":[{"id":1730,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2493,"direction":"\u003e","locations":"Mitochondrion","altext":"10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) + H(2)O = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY490279","genbank_protein_id":"40457276","gene_card_id":"FMT1","chromosome_location":"chromosome 2","locus":"YBL013W","synonyms":["MtFMT"],"enzyme_classes":["2.1.2.9"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" hydroxymethyl-, formyl- and related transferase activity"},{"category":"Function","description":" methionyl-tRNA formyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"}],"pfams":[{"name":"Formyl_trans_N","identifier":"PF00551"},{"name":"Formyl_trans_C","identifier":"PF02911"}],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"}],"gene_sequence":"ATGGTTAAAATGAGAAGAATAACACCTACACGCCTCCTATTCACATGCAGATATATTTCAAACAATGCTTCTCCACCAGTGCAGCCCTTGAATGTGCTTTTCTTTGGTAGCGACACTTTCAGTAATTTCTCATTGCAAGCACTCAATGAGTTGCGTCAAAATAATGGAAGCTGTGGTATAGTGGACAATATTCAAGTAGTAACTAGGTCGCCGAAGTGGTGCGGTAGACAGAAGTCTATTTTGAAATACCCGCCGATCTTCGATATGGCAGAGAAGCTTCAATTGCCACGCCCAATTACATGCGACACCAAGCAGGAAATGTTGGCGCTAAGCAAACTGACACCCAGTCGCCAAGGAAATCCGGAGAACGACGGCTCCGGTGCTCCGTTCAACGCGATCATTGCGGTTTCTTTTGGGAAGCTCATTCCGGGTGACTTGATCCGCGCGGTGCCATTGGCGCTAAACGTCCATCCTTCGCTACTTCCCAGACATAAAGGCAGTGCACCTATCCAGCGAGCTCTGCTCGAGGGTGACACTTACACCGGTGTAACTATACAGACACTGCATCCGGATCGGTTTGACCATGGTGCAATTGTAGCGCAGACGGAGCCACTGGCGATCGCAACAATGCTGTCAAAAGGGAGAGTCAATGATTCGACGGCAGATTTTAATTCTGAGGGCCTGCCTCGGAGGACTGCCATACTGATGGACCAGTTGGGCGCCCTTGGCGCCCAACTTTTGGGCCAAACGCTTCGTGAGAGGTTATATCTACCACAGAACCGTGTGCAAGCGCCAACAGCTTACAAACCCAGTTACGCCCACCGTATAACAACAGAAGATAAACGCATTCATTGGGCGCGCGATTCTGCCGCCGAACTACTTAACAAACTCGAAACGCTCGGTCCTCTGCACGCGTTCAAAGAAGCGACAGCGGCAAGAAAGGACGCTCAAAATTCAGTATTAAAACGAATATTGTTTCATGAGTGTAAAGTGATGAGAGACGCACGTCTAGATAATGGCAGTAAACCGGGCATGTTCAAATATGATGATATTAAAGACTGTATTTTGGTCACCTGTCGCGGCAACTTACTACTATGTGTGAGCCGCCTCCAGTTCGAAGGTTTCGCCGTAGAACGTGCTGGCCAGTTCATGGCGCGCCTGCGGAAAAGATGCGGCGCCCTGAGTGAAAAGTTAGTTTTCCTGTAA","protein_sequence":"MVKMRRITPTRLLFTCRYISNNASPPVQPLNVLFFGSDTFSNFSLQALNELRQNNGSCGIVDNIQVVTRSPKWCGRQKSILKYPPIFDMAEKLQLPRPITCDTKQEMLALSKLTPSRQGNPENDGSGAPFNAIIAVSFGKLIPGDLIRAVPLALNVHPSLLPRHKGSAPIQRALLEGDTYTGVTIQTLHPDRFDHGAIVAQTEPLAIATMLSKGRVNDSTADFNSEGLPRRTAILMDQLGALGAQLLGQTLRERLYLPQNRVQAPTAYKPSYAHRITTEDKRIHWARDSAAELLNKLETLGPLHAFKEATAARKDAQNSVLKRILFHECKVMRDARLDNGSKPGMFKYDDIKDCILVTCRGNLLLCVSRLQFEGFAVERAGQFMARLRKRCGALSEKLVFL"},{"created_at":"2011-05-26T17:53:55.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"C-1-tetrahydrofolate synthase, cytoplasmic","uniprot_id":"P07245","uniprot_name":"C1TC_YEAST","enzyme":true,"transporter":false,"gene_name":"ADE3","num_residues":946,"molecular_weight":"102204.0","theoretical_pi":"6.83","general_function":"Involved in formate-tetrahydrofolate ligase activity","specific_function":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH","reactions":[{"id":1548,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1727,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1733,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2488,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2489,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null},{"id":2490,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Mitochondrion","altext":"ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"AY692966","genbank_protein_id":"51013383","gene_card_id":"ADE3","chromosome_location":"chromosome 7","locus":"YGR204W","synonyms":["C1-THF synthase","Methylenetetrahydrofolate dehydrogenase","Methenyltetrahydrofolate cyclohydrolase","Formyltetrahydrofolate synthetase"],"enzyme_classes":["1.5.1.5","3.5.4.9","6.3.4.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" formate-tetrahydrofolate ligase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FTHFS","identifier":"PF01268"},{"name":"THF_DHG_CYH","identifier":"PF00763"},{"name":"THF_DHG_CYH_C","identifier":"PF02882"}],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"One carbon pool by folate","kegg_map_id":"00670"}],"gene_sequence":"ATGGCTGGTCAAGTGTTGGACGGCAAAGCATGCGCTCAGCAGTTTAGAAGCAATATTGCTAATGAAATCAAAAGCATTCAAGGTCACGTGCCTGGGTTTGCACCTAACCTTGCCATCATTCAAGTAGGCAACAGACCAGACTCAGCCACATATGTACGCATGAAGCGTAAGGCAGCTGAAGAGGCCGGCATTGTTGCTAATTTCATTCATTTAGATGAATCCGCTACTGAATTTGAAGTTCTGCGTTACGTGGACCAGCTGAATGAGGACCCACATACACACGGTATTATCGTGCAACTACCATTACCCGCTCATTTGGACGAGGATAGAATCACCTCGAGAGTGTTGGCAGAAAAGGACGTGGACGGGTTCGGGCCCACCAACATTGGCGAATTGAATAAGAAGAACGGACACCCATTCTTTTTGCCCTGCACGCCCAAGGGGATCATTGAGCTGCTTCACAAGGCCAACGTCACGATTGAAGGTTCCCGGTCCGTTGTGATCGGAAGATCTGACATTGTTGGCTCTCCTGTTGCAGAATTGTTAAAATCTCTAAACTCCACCGTCACCATCACTCATTCTAAAACCCGTGATATCGCATCATACTTACACGACGCGGACATCGTAGTCGTTGCCATCGGCCAACCAGAATTTGTGAAGGGTGAATGGTTCAAACCAAGAGACGGCACTTCCAGTGATAAGAAAACCGTGGTAATTGATGTTGGCACCAACTACGTTGCTGATCCTTCCAAAAAGTCCGGTTTCAAATGTGTTGGTGACGTTGAGTTCAATGAAGCAATCAAATACGTCCATCTAATCACTCCAGTGCCCGGTGGTGTGGGCCCCATGACGGTGGCTATGTTAATGCAAAATACCTTGATTGCTGCCAAACGCCAAATGGAAGAATCCTCGAAGCCTTTGCAGATTCCTCCCTTGCCATTGAAGTTGCTAACACCTGTTCCTTCCGATATAGACATCTCCAGAGCACAACAGCCAAAGCTTATCAACCAGCTTGCTCAAGAATTGGGTATTTACTCTCATGAGTTGGAGCTGTACGGACATTACAAGGCCAAAATTTCTCCTAAAGTCATCGAAAGGCTGCAGACGCGCCAAAATGGTAAGTACATCTTGGTGTCTGGTATCACACCAACACCACTGGGAGAGGGTAAATCCACTACAACAATGGGTCTTGTCCAGGCACTAACGGCTCACTTGGGCAAGCCAGCCATTGCGAACGTCAGACAACCCTCCCTAGGACCCACTTTAGGTGTCAAAGGTGGTGCTGCGGGTGGTGGTTATTCCCAAGTCATCCCAATGGACGAATTCAACTTACATTTGACTGGTGACATTCACGCCATTGGTGCGGCTAACAACCTACTTGCTGCCGCTATTGACACTAGAATGTTCCATGAGACCACTCAAAAGAACGACGCTACCTTCTACAACAGACTAGTGCCTAGAAAGAACGGAAAGAGAAAGTTTACTCCCTCCATGCAAAGAAGATTGAACAGACTGGGTATTCAAAAGACCAACCCCGATGATCTAACACCCGAAGAGATCAACAAATTCGCCAGATTGAACATTGACCCGGACACTATTACTATCAAGAGGGTGGTCGATATCAACGACAGAATGTTAAGACAAATCACCATTGGTCAAGCCCCTACCGAGAAGAACCACACAAGAGTTACTGGATTCGATATCACCGTTGCTTCTGAATTGATGGCTATTCTTGCTCTTTCAAAGGACTTGAGGGACATGAAGGAACGTATTGGAAGAGTCGTTGTTGCTGCTGACGTAAACAGGTCTCCAGTCACTGTTGAAGATGTGGGTTGTACCGGTGCCTTAACCGCTTTATTAAGAGACGCTATCAAGCCCAACTTGATGCAAACTTTAGAAGGTACTCCTGTCTTGGTCCATGCCGGCCCATTTGCCAACATCTCTATCGGTGCCTCTTCTGTTATTGCTGATCGCGTGGCTTTGAAATTGGTTGGTACCGAGCCAGAGGCAAAAACAGAAGCTGGTTATGTGGTTACTGAAGCAGGGTTCGATTTCACTATGGGTGGTGAAAGATTCTTCAACATCAAGTGCCGTTCCTCTGGATTGACACCTAATGCTGTGGTCTTGGTTGCTACTGTTAGGGCATTGAAGTCACACGGTGGTGCTCCAGATGTCAAACCTGGCCAACCTTTACCTTCCGCATACACTGAAGAGAATATCGAGTTTGTCGAAAAAGGTGCCGCTAACATGTGTAAACAAATTGCCAACATTAAGCAATTTGGCGTCCCCGTCGTTGTCGCAATTAACAAGTTTGAAACTGACACTGAAGGTGAAATAGCCGCCATTAGAAAAGCCGCTTTGGAAGCTGGTGCATTTGAAGCCGTAACCTCTAACCATTGGGCCGAAGGTGGTAAAGGTGCTATCGACTTGGCCAAGGCCGTCATCGAAGCTTCCAACCAACCAGTGGACTTCCATTTCCTATATGACGTTAACTCCTCCGTTGAAGACAAATTAACTACTATCGTTCAAAAGATGTACGGTGGTGCCGCAATCGATATCTTGCCTGAAGCACAACGCAAGATTGACATGTACAAGGAACAAGGTTTCGGTAACTTGCCAATTTGTATCGCCAAGACACAATACTCTTTATCCCACGATGCAACTTTGAAAGGTGTTCCAACCGGGTTCACTTTCCCCATCAGAGACGTCAGATTGTCTAATGGTGCTGGATACTTATACGCTCTTGCCGCCGAAATACAAACCATTCCTGGTTTGGCTACCTATGCTGGTTACATGGCCGTGGAAGTCGATGATGACGGTGAGATCGATGGCCTGTTCTAA","protein_sequence":"MAGQVLDGKACAQQFRSNIANEIKSIQGHVPGFAPNLAIIQVGNRPDSATYVRMKRKAAEEAGIVANFIHLDESATEFEVLRYVDQLNEDPHTHGIIVQLPLPAHLDEDRITSRVLAEKDVDGFGPTNIGELNKKNGHPFFLPCTPKGIIELLHKANVTIEGSRSVVIGRSDIVGSPVAELLKSLNSTVTITHSKTRDIASYLHDADIVVVAIGQPEFVKGEWFKPRDGTSSDKKTVVIDVGTNYVADPSKKSGFKCVGDVEFNEAIKYVHLITPVPGGVGPMTVAMLMQNTLIAAKRQMEESSKPLQIPPLPLKLLTPVPSDIDISRAQQPKLINQLAQELGIYSHELELYGHYKAKISPKVIERLQTRQNGKYILVSGITPTPLGEGKSTTTMGLVQALTAHLGKPAIANVRQPSLGPTLGVKGGAAGGGYSQVIPMDEFNLHLTGDIHAIGAANNLLAAAIDTRMFHETTQKNDATFYNRLVPRKNGKRKFTPSMQRRLNRLGIQKTNPDDLTPEEINKFARLNIDPDTITIKRVVDINDRMLRQITIGQAPTEKNHTRVTGFDITVASELMAILALSKDLRDMKERIGRVVVAADVNRSPVTVEDVGCTGALTALLRDAIKPNLMQTLEGTPVLVHAGPFANISIGASSVIADRVALKLVGTEPEAKTEAGYVVTEAGFDFTMGGERFFNIKCRSSGLTPNAVVLVATVRALKSHGGAPDVKPGQPLPSAYTEENIEFVEKGAANMCKQIANIKQFGVPVVVAINKFETDTEGEIAAIRKAALEAGAFEAVTSNHWAEGGKGAIDLAKAVIEASNQPVDFHFLYDVNSSVEDKLTTIVQKMYGGAAIDILPEAQRKIDMYKEQGFGNLPICIAKTQYSLSHDATLKGVPTGFTFPIRDVRLSNGAGYLYALAAEIQTIPGLATYAGYMAVEVDDDGEIDGLF"},{"created_at":"2011-05-26T17:54:29.000Z","updated_at":"2011-07-22T17:53:51.000Z","name":"5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase","uniprot_id":"P05694","uniprot_name":"METE_YEAST","enzyme":true,"transporter":false,"gene_name":"MET6","num_residues":767,"molecular_weight":"85859.20313","theoretical_pi":"6.41","general_function":"Involved in 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity","specific_function":"Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation","reactions":[{"id":1218,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1729,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2494,"direction":"\u003e","locations":null,"altext":"5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.","export":false,"pw_reaction_id":null,"source":null},{"id":3784,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006306","source":"Smpdb"},{"id":3785,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006776","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"DQ393811","genbank_protein_id":"88910023","gene_card_id":"MET6","chromosome_location":"chromosome 5","locus":"YER091C","synonyms":["Cobalamin-independent methionine synthase","Delta-P8 protein","Methionine synthase, vitamin-B12 independent isozyme"],"enzyme_classes":["2.1.1.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" S-methyltransferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" methionine biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" sulfur amino acid metabolic process"},{"category":"Process","description":" sulfur amino acid biosynthetic process"}],"pfams":[{"name":"Meth_synt_1","identifier":"PF08267"},{"name":"Meth_synt_2","identifier":"PF01717"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Selenocompound metabolism","kegg_map_id":"00450"}],"gene_sequence":"ATGGTTCAATCTGCTGTCTTAGGGTTCCCAAGAATCGGTCCAAACAGAGAATTAAAGAAGGCCACTGAAGGTTACTGGAACGGTAAAATCACTGTCGATGAATTATTCAAGGTCGGTAAGGATTTGAGAACTCAAAACTGGAAGTTGCAAAAGGAGGCTGGTGTTGATATCATCCCATCCAATGACTTCTCCTTTTACGACCAAGTTTTGGATTTGTCTTTGTTGTTCAATGTCATTCCAGACCGTTACACTAAGTACGATCTATCTCCAATCGACACTTTGTTTGCTATGGGTAGAGGTTTACAAAGAAAGGCCACTGAAACTGAAAAGGCTGTCGACGTCACTGCTTTGGAAATGGTTAAATGGTTCGACTCTAACTACCATTACGTTAGACCAACTTTCTCCAAGACCACTCAATTTAAGTTGAACGGCCAAAAGCCAGTTGACGAATTTTTGGAAGCCAAGGAGTTAGGTATTCATACTAGACCTGTCTTGTTGGGTCCAGTTTCTTACTTATTCTTGGGTAAGGCTGACAAGGATTCTCTAGATTTGGAACCATTGTCCCTATTGGAACAATTGTTGCCTCTATACACTGAAATCCTATCTAAATTGGCTTCTGCTGGTGCCACTGAAGTTCAAATTGACGAACCTGTCTTAGTTTTGGACTTGCCTGCCAACGCCCAAGCCGCCATTAAGAAGGCTTACACTTACTTCGGTGAACAAAGCAATCTACCAAAGATTACTTTGGCTACTTACTTCGGTACCGTTGTCCCTAACTTAGACGCCATCAAGGGCTTGCCAGTTGCTGCCTTACACGTTGACTTTGTTAGAGCTCCAGAACAATTTGATGAAGTCGTTGCCGCCATTGGTAACAAACAAACCTTGTCTGTTGGTATTGTTGATGGTAGAAACATTTGGAAGAATGATTTCAAGAAGTCTTCCGCTATCGTTAACAAGGCTATTGAAAAGTTGGGTGCTGACAGAGTCGTTGTTGCCACTTCTTCTTCTCTATTGCACACACCAGTTGATTTGAACAACGAAACCAAGTTGGACGCTGAAATCAAGGGCTTTTTCTCTTTCGCCACTCAAAAATTGGATGAAGTTGTTGTGATCACCAAGAACGTTTCCGGTCAAGACGTTGCTGCTGCCCTAGAAGCTAACGCTAAATCTGTTGAATCCAGAGGTAAATCCAAGTTTATCCACGATGCTGCCGTTAAGGCCAGAGTTGCCTCTATCGACGAAAAAATGTCTACTAGAGCAGCTCCATTTGAACAAAGATTGCCTGAACAACAAAAAGTCTTCAACTTGCCATTGTTCCCAACAACAACTATTGGTTCCTTCCCTCAAACCAAGGACATCAGAATTAACAGAAACAAATTCAACAAGGGTACCATCTCTGCTGAAGAATATGAAAAATTCATCAATTCTGAAATTGAAAAGGTCATCAGATTCCAAGAAGAAATTGGTTTGGATGTCTTAGTCCACGGTGAACCAGAAAGAAACGATATGGTTCAATACTTCGGTGAACAAATCAACGGTTATGCTTTCACTGTTAACGGTTGGGTTCAATCTTACGGTTCCAGATATGTCAGACCACCAATTATTGTTGGTGACTTGTCCAGACCAAAGGCTATGTCCGTCAAGGAATCTGTTTACGCTCAATCCATCACTTCTAAGCCAGTAAAGGGTATGTTGACTGGTCCAATTACCTGTTTGAGATGGTCTTTCCCAAGAGACGATGTCGACCAAAAAACTCAAGCTATGCAATTAGCTTTGGCTTTGAGAGATGAAGTCAATGATTTGGAAGCTGCCGGTATCAAGGTTATCCAAGTTGATGAACCAGCTTTAAGAGAAGGTTTACCATTGAGAGAAGGTACTGAGAGATCTGCTTACTACACCTGGGCTGCCGAAGCTTTCAGAGTTGCTACTTCTGGTGTTGCTAACAAGACTCAAATACACTCTCATTTCTGTTACTCTGACTTGGATCCAAACCATATCAAGGCTTTGGATGCTGATGTTGTTTCCATCGAATTCTCTAAGAAGGACGATGCTAACTACATTGCTGAATTCAAAAACTATCCAAACCACATTGGTCTAGGTTTATTCGATATTCATTCTCCAAGAATTCCATCAAAGGATGAATTTATCGCCAAGATTTCAACCATCTTGAAGAGCTACCCAGCTGAAAAGTTCTGGGTTAACCCAGATTGTGGTTTGAAGACTAGAGGCTGGGAAGAAACTAGATTGTCTTTGACTCATATGGTCGAAGCCGCCAAGTACTTCCGTGAACAATACAAGAATTAA","protein_sequence":"MVQSAVLGFPRIGPNRELKKATEGYWNGKITVDELFKVGKDLRTQNWKLQKEAGVDIIPSNDFSFYDQVLDLSLLFNVIPDRYTKYDLSPIDTLFAMGRGLQRKATETEKAVDVTALEMVKWFDSNYHYVRPTFSKTTQFKLNGQKPVDEFLEAKELGIHTRPVLLGPVSYLFLGKADKDSLDLEPLSLLEQLLPLYTEILSKLASAGATEVQIDEPVLVLDLPANAQAAIKKAYTYFGEQSNLPKITLATYFGTVVPNLDAIKGLPVAALHVDFVRAPEQFDEVVAAIGNKQTLSVGIVDGRNIWKNDFKKSSAIVNKAIEKLGADRVVVATSSSLLHTPVDLNNETKLDAEIKGFFSFATQKLDEVVVITKNVSGQDVAAALEANAKSVESRGKSKFIHDAAVKARVASIDEKMSTRAAPFEQRLPEQQKVFNLPLFPTTTIGSFPQTKDIRINRNKFNKGTISAEEYEKFINSEIEKVIRFQEEIGLDVLVHGEPERNDMVQYFGEQINGYAFTVNGWVQSYGSRYVRPPIIVGDLSRPKAMSVKESVYAQSITSKPVKGMLTGPITCLRWSFPRDDVDQKTQAMQLALALRDEVNDLEAAGIKVIQVDEPALREGLPLREGTERSAYYTWAAEAFRVATSGVANKTQIHSHFCYSDLDPNHIKALDADVVSIEFSKKDDANYIAEFKNYPNHIGLGLFDIHSPRIPSKDEFIAKISTILKSYPAEKFWVNPDCGLKTRGWEETRLSLTHMVEAAKYFREQYKN"},{"created_at":"2011-05-26T18:21:30.000Z","updated_at":"2011-07-22T17:53:47.000Z","name":"3-methyl-2-oxobutanoate hydroxymethyltransferase","uniprot_id":"P38122","uniprot_name":"PANB_YEAST","enzyme":true,"transporter":false,"gene_name":"ECM31","num_residues":312,"molecular_weight":"34464.69922","theoretical_pi":"8.26","general_function":"Involved in 3-methyl-2-oxobutanoate hydroxymethyltransferase activity","specific_function":"5,10-methylenetetrahydrofolate + 3-methyl-2- oxobutanoate + H(2)O = tetrahydrofolate + 2-dehydropantoate","reactions":[{"id":1185,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2526,"direction":"\u003e","locations":null,"altext":"5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H(2)O = tetrahydrofolate + 2-dehydropantoate.","export":false,"pw_reaction_id":null,"source":null},{"id":14215,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006654","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z36045","genbank_protein_id":"536525","gene_card_id":"ECM31","chromosome_location":"chromosome 2","locus":"YBR176W","synonyms":["Extracellular matrix protein 31","Ketopantoate hydroxymethyltransferase"],"enzyme_classes":["2.1.2.11"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" glycine hydroxymethyltransferase activity"},{"category":"Function","description":" hydroxymethyl-, formyl- and related transferase activity"},{"category":"Function","description":" 3-methyl-2-oxobutanoate hydroxymethyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" pantothenate biosynthetic process"}],"pfams":[{"name":"Pantoate_transf","identifier":"PF02548"}],"pathways":[{"name":"Pantothenate and CoA 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wall maturation protein DIT1","uniprot_id":"P21623","uniprot_name":"DIT1_YEAST","enzyme":true,"transporter":false,"gene_name":"DIT1","num_residues":536,"molecular_weight":"61390.10156","theoretical_pi":"6.51","general_function":"Secondary metabolites biosynthesis, transport and catabolism","specific_function":"Involved in spore wall maturation. Catalyzes a two step reaction that leads to the LL-dityrosine containing precursor of the spore wall","reactions":[{"id":1708,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U32274","genbank_protein_id":"927334","gene_card_id":"DIT1","chromosome_location":"chromosome 4","locus":"YDR403W","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[{"name":"DIT1_PvcA","identifier":"PF05141"}],"pathways":[],"gene_sequence":"ATGACATTTACTAGCAACTTGCCCTCAAGCTCCGAGCAGTCAATATCACCACCTGCCTCTTCATTTTCTTCATCGACTGATACGTTGAAAGATATTGATATTCCCCATAATGGGGCCGATTTGTCTACATATAGTAAATTTCTGGCCCTGTATTGCAGAAGCGACAAATGTGACGATTTTTACTCTTTAGAGGAAAAACAGAATTGTAAATTTGGAGACCAATGGCTCGACTTTATCAACACTATTCACAATCTGGACTTTTCTGAATCCGAAGTAAGTGGACGGGTTTCTGAAAGAATTTTGCCAGCTTCTTTAGCAAATAAATTTACCAATAATTTAGGAGTGGCAATAAAGATTTCTGAATATACACGCGATGACGAACGCCAGATTCGTGGGTGTGTTACAACAGTTGAGAATGAAAATTCTTTCAATAACTGGTTCGTATATCATATTTTAGACCAATCTCAATTATCTCTAAGTGAACATCCAATTGTAACCAAAGAAGTTAAGTATCACGAATTATTTGCAGATTTTTTTGAGAAAAATTTGAAAAACACAATAGTTAATGATCAATGGAATTTTGGTGGCCGTGATTATTTTATTGAACGTTCAAGATATTTTACCGATCGATATTTGAGAATTGAATGCATCTTGCCAGCGTTTCCATGTAAGTCATCTAATGAGCAAAAAGTGTACGGTTCCGTTCCTGACAAAGGCGAAGAACTCGCTTTGAAAAGATTAATAAAAGCCACACAAGACCTTGTCAAGATATATCCACCGGGTATGAAAATTTGGATAGTTAGTGATGGCCATGTTTTCTCCGATTGTATTGGGGTCGATGATGACGTCGTGAGTACTTACACGACCAAATTGCACGAACTGTATAAAAGAGTGGCTATACCTGGTGTTGACGCCATTGGCTTTTGTGGATTGAACGATTTATTTTTTAGCGGTGCAGCTAGTAAAGTTTTCGATCCAAAGTGGGTTAGTGATGTTGAAGTTGCACACTACACAGGAACTCAAATCTGTCCTAAGTCCGATTTGTCGAGACAGATTTTGATGAAAGGCTGTGATACAGATGCAGGTCGTTTGAGAAAGCAGATTGCAATAGAAGGACATCCAAGATTGCATCTGTATAGGGGCTTTTCACGTTTTATGATGGAAGATTTATCTCTACTGGAACATTTCCAAAGTTATTCCAGAAAAAAATTCAAGAAAATCATTTCAATGATCGCTTTTAACATGATTAAGAGAAATGACGCGTATTCGAACTTAGTGGAATTGATATTCCCTCATCATTTGAGAATTTCTATTCATGCGCACACTAACAGCGGGCCCAAATTTGGTATAAAAGTAATCTCCAACGAACAGTGTTCTATTGTTAGTTCGTTAGAAGACCTTGATGAACCCAAATTTGAAGATTTTTTACATATTCCCACACCTTGGCATAATTGTGTCGTGAAGGTTGAGGATGAAAAGGAGAAATACTTTTTGACAAAATCAAAAGTAGTCAAGGAGGCTCTCGAAAAGGGTATGTATGATGGTGTATGGAAAGATACTCGTTTCGATATTGGAGAAGGAGGACATTTCGTTATCAAGAAAATCTCTTAA","protein_sequence":"MTFTSNLPSSSEQSISPPASSFSSSTDTLKDIDIPHNGADLSTYSKFLALYCRSDKCDDFYSLEEKQNCKFGDQWLDFINTIHNLDFSESEVSGRVSERILPASLANKFTNNLGVAIKISEYTRDDERQIRGCVTTVENENSFNNWFVYHILDQSQLSLSEHPIVTKEVKYHELFADFFEKNLKNTIVNDQWNFGGRDYFIERSRYFTDRYLRIECILPAFPCKSSNEQKVYGSVPDKGEELALKRLIKATQDLVKIYPPGMKIWIVSDGHVFSDCIGVDDDVVSTYTTKLHELYKRVAIPGVDAIGFCGLNDLFFSGAASKVFDPKWVSDVEVAHYTGTQICPKSDLSRQILMKGCDTDAGRLRKQIAIEGHPRLHLYRGFSRFMMEDLSLLEHFQSYSRKKFKKIISMIAFNMIKRNDAYSNLVELIFPHHLRISIHAHTNSGPKFGIKVISNEQCSIVSSLEDLDEPKFEDFLHIPTPWHNCVVKVEDEKEKYFLTKSKVVKEALEKGMYDGVWKDTRFDIGEGGHFVIKKIS"},{"created_at":"2011-05-27T17:52:41.000Z","updated_at":"2011-05-29T05:06:52.000Z","name":"Folylpolyglutamate synthase","uniprot_id":"Q08645","uniprot_name":"FOLE_YEAST","enzyme":true,"transporter":false,"gene_name":"MET7","num_residues":548,"molecular_weight":"62150.89844","theoretical_pi":"9.24","general_function":"Coenzyme transport and metabolism","specific_function":"Conversion of folates to polyglutamate derivatives","reactions":[{"id":1996,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2486,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion. Cytoplasm;Mitochondrion","altext":"ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion. Cytoplasm","genbank_gene_id":"AY692818","genbank_protein_id":"51013087","gene_card_id":"MET7","chromosome_location":"chromosome 15","locus":"YOR241W","synonyms":["Folylpoly-gamma-glutamate synthetase","FPGS","Tetrahydrofolylpolyglutamate synthase","Tetrahydrofolate synthase"],"enzyme_classes":["6.3.2.17"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" acid-amino acid ligase activity"},{"category":"Function","description":" tetrahydrofolylpolyglutamate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" folic acid and derivative metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" folic acid and derivative biosynthetic process"}],"pfams":[],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"}],"gene_sequence":"ATGCATAAAGGAAAAAAAAATTACCCTAATTTGATTACTTCGTTTCGGATGAATTTGAAAAAAATCATATTGAACCATGACCGATTTAGCCATCCAGAAAGATGGAAAACAAACGCACTCTTAAGGTTCACCTTCGTGTATATAAAATTTCTCTTCGACTTGATGATAATCAAAAATCCATTAAGGATGGTTGGAAAAACTTATCGAGACGCTGTTACTGCGCTAAACTCTTTGCAGTCCAATTATGCCAACATCATGGCTATCCGTCAAACTGGTGATCGTAAAAACACTATGACATTATTGGAAATGCATGAATGGTCTCGAAGAATTGGTTACTCTGCATCGGATTTCAATAAATTAAATATTGTTCATATCACTGGAACAAAAGGTAAAGGTTCTACTGCCGCATTTACTTCATCAATTCTAGGACAATATAAAGAACAATTACCACGTATCGGGCTATATACGTCTCCACATCTTAAGTCAGTGAGAGAAAGAATAAGAATAAATGGGGAGCCAATTTCTGAAGAAAAATTTGCGAAGTACTTCTTTGAGGTTTGGGACCGTCTAGATAGTACAACCTCTTCTTTGGATAAATTCCCGCACATGATCCCGGGAAGTAAGCCTGGCTATTTCAAGTTCCTCACATTGCTTTCATTTCACACTTTTATACAAGAGGACTGCAAAAGCTGTGTCTACGAAGTCGGCGTCGGAGGTGAATTGGATAGCACTAATATAATTGAAAAGCCAATTGTCTGCGGTGTTACACTATTAGGAATAGACCATACTTTCATGCTTGGTGATACTATTGAAGAAATTGCTTGGAATAAGGGAGGAATTTTCAAATCTGGAGCACCAGCATTCACCGTTGAGAAACAACCTCCTCAGGGATTAACAATATTGAAAGAAAGAGCTGAGGAGCGCAAAACAACGCTAACAGAAGTACCCCCATTTAAACAGTTGGAAAATGTCAAGCTTGGAATTGCTGGCGAGTTTCAAAAAAGTAACGCCTCCCTTGCCGTTATGCTGGCTTCTGAGATCTTGCATACGTCCAATATATTGGAGGAGAAGATCAAATGCAGTTCGAATGCATCGATTCCAGAAAAATTCATAATCGGTCTACAAAATACTAAGTGGGAAGGCAGATGTCAAGTACTAGAAAAGGGAAAAAACGTTTGGTACATTGATGGTGCTCACACCAAAGATAGTATGGTAGCTGCATCAACATGGTTCAGAGATATGGTTCGATTGTCGAAGAGAAAGAAGATCTTGCTCTTCAACCAACAAAGCAGAGATGCCAACGCTCTTGTGAATAACCTGTACTCATCTGTTTCGCCAGAAATAACGTTCGATGATGTGATATTTACTACTAATGTCACTTGGAAATCAGGCTCATACAGCGCTGACCTCGTTTCCATGAACACTTCTCAAGAAGATGTAGAAAAATTGAAAGTCCAGGAGTCATTAGTCAAGAATTGGAACAAAATAGACGATAATCGTGCTAAAACGCATGTAACGGCTAGTATAGAGGAAGCAAATGAATTGATTGAAACGCTATACGATGAACCTGCTGATATATTTGTAACTGGTTCATTACATCTTGTTGGCGGATTATTGGTCGTTTTTGATAGAATAGATGTAAAGTAA","protein_sequence":"MHKGKKNYPNLITSFRMNLKKIILNHDRFSHPERWKTNALLRFTFVYIKFLFDLMIIKNPLRMVGKTYRDAVTALNSLQSNYANIMAIRQTGDRKNTMTLLEMHEWSRRIGYSASDFNKLNIVHITGTKGKGSTAAFTSSILGQYKEQLPRIGLYTSPHLKSVRERIRINGEPISEEKFAKYFFEVWDRLDSTTSSLDKFPHMIPGSKPGYFKFLTLLSFHTFIQEDCKSCVYEVGVGGELDSTNIIEKPIVCGVTLLGIDHTFMLGDTIEEIAWNKGGIFKSGAPAFTVEKQPPQGLTILKERAEERKTTLTEVPPFKQLENVKLGIAGEFQKSNASLAVMLASEILHTSNILEEKIKCSSNASIPEKFIIGLQNTKWEGRCQVLEKGKNVWYIDGAHTKDSMVAASTWFRDMVRLSKRKKILLFNQQSRDANALVNNLYSSVSPEITFDDVIFTTNVTWKSGSYSADLVSMNTSQEDVEKLKVQESLVKNWNKIDDNRAKTHVTASIEEANELIETLYDEPADIFVTGSLHLVGGLLVVFDRIDVK"}]}