{"ymdb_id":"YMDB16164","created_at":"2016-09-12T18:18:37.000Z","updated_at":"2016-10-17T22:34:42.000Z","name":"4-Hydroxyphenylacetaldehyde","cas":null,"state":"Solid","melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"2-(4-hydroxyphenyl)acetaldehyde","traditional_iupac":"p-hydroxyphenylacetaldehyde","logp":"1.1488125313333333","pka":"15.740035558358176","alogps_solubility":"5.93e+00 g/l","alogps_logp":"1.59","alogps_logs":"-1.36","acceptor_count":"2","donor_count":"1","rotatable_bond_count":"2","polar_surface_area":"37.3","refractivity":"38.4211","polarizability":"13.867420792297285","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-5.958495345707978","pka_strongest_acidic":"9.498768628678677","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"1","mddr_like_rule":"0","synonyms":[],"pathways":[{"name":"Tyrosine metabolism","kegg_map_id":"00350"}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-24T20:26:42.000Z","updated_at":"2011-07-22T17:53:52.000Z","name":"Pyruvate decarboxylase isozyme 2","uniprot_id":"P16467","uniprot_name":"PDC5_YEAST","enzyme":true,"transporter":false,"gene_name":"PDC5","num_residues":563,"molecular_weight":"61911.60156","theoretical_pi":"6.4","general_function":"Involved in magnesium ion binding","specific_function":"Second most abundant of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids valine, isoleucine, phenylalanine, and tryptophan, whereas leucine is no substrate. 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