{"ymdb_id":"YMDB00587","created_at":"2011-05-29T18:33:23.000Z","updated_at":"2016-09-08T18:35:39.000Z","name":"4-aminobutanal","cas":"4390-05-0","state":"Solid","melting_point":null,"description":"4-Aminobutanal is the product in arginine degradation pathway. [Biocyc ARGDEG-V-PWY]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"mitochondrion;cytoplasm","synthesis_reference":"Asakura, Tadashi; Takada, Koji; Ikeda, Yoshitaka; Matsuda, Makoto.  Preparation of 4-aminobutyraldehyde and its properties on ion exchange chromatography.    Jikeikai Medical Journal  (1988),  35(1),  23-31.","chebi_id":"17769","hmdb_id":"HMDB01080","kegg_id":"C00555","pubchem_id":"118","cs_id":"115","foodb_id":null,"wikipedia_link":null,"biocyc_id":"4-AMINO-BUTYRALDEHYDE","iupac":"4-aminobutanal","traditional_iupac":"ω-aminoaldehyde","logp":"-0.780417868","pka":null,"alogps_solubility":"2.59e+02 g/l","alogps_logp":"-0.73","alogps_logs":"0.47","acceptor_count":"2","donor_count":"1","rotatable_bond_count":"3","polar_surface_area":"43.09","refractivity":"24.532400000000003","polarizability":"9.71572746213239","formal_charge":"0","physiological_charge":"1","pka_strongest_basic":"9.792866479907637","pka_strongest_acidic":"14.828866437700317","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["4-amino-butanal","4-amino-butyraldehyde","4-Aminobutanal","4-aminobutyraldehyde","ABAL","Butyraldehyde, 4-amino-","gamma-aminobutanal","gamma-aminobutyraldehyde"],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-24T20:26:04.000Z","updated_at":"2011-07-22T17:54:11.000Z","name":"Potassium-activated aldehyde dehydrogenase, mitochondrial","uniprot_id":"P46367","uniprot_name":"ALDH4_YEAST","enzyme":true,"transporter":false,"gene_name":"ALD4","num_residues":519,"molecular_weight":"56723.19922","theoretical_pi":"6.72","general_function":"Involved in oxidoreductase activity","specific_function":"An aldehyde + NAD(+) + H(2)O = an acid + NADH","reactions":[{"id":1299,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1300,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1301,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1302,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1321,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2318,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"An aldehyde + NAD(+) + H(2)O = an acid + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":3863,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006384","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"Z75282","genbank_protein_id":"1420808","gene_card_id":"ALD4","chromosome_location":"chromosome 15","locus":"YOR374W","synonyms":["K(+)-activated acetaldehyde dehydrogenase","K(+)-ACDH"],"enzyme_classes":["1.2.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Aldedh","identifier":"PF00171"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Fatty acid metabolism","kegg_map_id":"00071"},{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Lysine degradation","kegg_map_id":"00310"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Glycerolipid metabolism","kegg_map_id":"00561"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"threonine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTCAGTAGATCTACGCTCTGCTTAAAGACGTCTGCATCCTCCATTGGGAGACTTCAATTGAGATATTTCTCACACCTTCCTATGACAGTGCCTATCAAGCTGCCCAATGGGTTGGAATATGAGCAACCAACGGGGTTGTTCATCAACAACAAGTTTGTTCCTTCTAAACAGAACAAGACCTTCGAAGTCATTAACCCTTCCACGGAAGAAGAAATATGTCATATTTATGAAGGTAGAGAGGACGATGTGGAAGAGGCCGTGCAGGCCGCCGACCGTGCCTTCTCTAATGGGTCTTGGAACGGTATCGACCCTATTGACAGGGGTAAGGCTTTGTACAGGTTAGCCGAATTAATTGAACAGGACAAGGATGTCATTGCTTCCATCGAGACTTTGGATAACGGTAAAGCTATCTCTTCCTCGAGAGGAGATGTTGATTTAGTCATCAACTATTTGAAATCTTCTGCTGGCTTTGCTGATAAAATTGATGGTAGAATGATTGATACTGGTAGAACCCATTTTTCTTACACTAAGAGACAGCCTTTGGGTGTTTGTGGGCAGATTATTCCTTGGAATTTCCCACTGTTGATGTGGGCCTGGAAGATTGCCCCTGCTTTGGTCACCGGTAACACCGTCGTGTTGAAGACTGCCGAATCCACCCCATTGTCCGCTTTGTATGTGTCTAAATACATCCCACAGGCGGGTATTCCACCTGGTGTGATCAACATTGTATCCGGGTTTGGTAAGATTGTGGGTGAGGCCATTACAAACCATCCAAAAATCAAAAAGGTTGCCTTCACAGGGTCCACGGCTACGGGTAGACACATTTACCAGTCCGCAGCCGCAGGCTTGAAAAAAGTGACTTTGGAGCTGGGTGGTAAATCACCAAACATTGTCTTCGCGGACGCCGAGTTGAAAAAAGCCGTGCAAAACATTATCCTTGGTATCTACTACAATTCTGGTGAGGTCTGTTGTGCGGGTTCAAGGGTGTATGTTGAAGAATCTATTTACGACAAATTCATTGAAGAGTTCAAAGCCGCTTCTGAATCCATCAAGGTGGGCGACCCATTCGATGAATCTACTTTCCAAGGTGCACAAACCTCTCAAATGCAACTAAACAAAATCTTGAAATACGTTGACATTGGTAAGAATGAAGGTGCTACTTTGATTACCGGTGGTGAAAGATTAGGTAGCAAGGGTTACTTCATTAAGCCAACTGTCTTTGGTGACGTTAAGGAAGACATGAGAATTGTCAAAGAGGAAATCTTTGGCCCTGTTGTCACTGTAACCAAATTCAAATCTGCCGACGAAGTCATTAACATGGCGAACGATTCTGAATACGGGTTGGCTGCTGGTATTCACACCTCTAATATTAATACCGCCTTAAAAGTGGCTGATAGAGTTAATGCGGGTACGGTCTGGATAAACACTTATAACGATTTCCACCACGCAGTTCCTTTCGGTGGGTTCAATGCATCTGGTTTGGGCAGGGAAATGTCTGTTGATGCTTTACAAAACTACTTGCAAGTTAAAGCGGTCCGTGCCAAATTGGACGAGTAA","protein_sequence":"MFSRSTLCLKTSASSIGRLQLRYFSHLPMTVPIKLPNGLEYEQPTGLFINNKFVPSKQNKTFEVINPSTEEEICHIYEGREDDVEEAVQAADRAFSNGSWNGIDPIDRGKALYRLAELIEQDKDVIASIETLDNGKAISSSRGDVDLVINYLKSSAGFADKIDGRMIDTGRTHFSYTKRQPLGVCGQIIPWNFPLLMWAWKIAPALVTGNTVVLKTAESTPLSALYVSKYIPQAGIPPGVINIVSGFGKIVGEAITNHPKIKKVAFTGSTATGRHIYQSAAAGLKKVTLELGGKSPNIVFADAELKKAVQNIILGIYYNSGEVCCAGSRVYVEESIYDKFIEEFKAASESIKVGDPFDESTFQGAQTSQMQLNKILKYVDIGKNEGATLITGGERLGSKGYFIKPTVFGDVKEDMRIVKEEIFGPVVTVTKFKSADEVINMANDSEYGLAAGIHTSNINTALKVADRVNAGTVWINTYNDFHHAVPFGGFNASGLGREMSVDALQNYLQVKAVRAKLDE"},{"created_at":"2011-05-24T20:29:39.000Z","updated_at":"2011-07-22T17:54:11.000Z","name":"Aldehyde dehydrogenase 5, mitochondrial","uniprot_id":"P40047","uniprot_name":"ALDH5_YEAST","enzyme":true,"transporter":false,"gene_name":"ALD5","num_residues":520,"molecular_weight":"56620.39844","theoretical_pi":"8.51","general_function":"Involved in oxidoreductase activity","specific_function":"Minor mitochondrial aldehyde dehydrogenase isoform. Plays a role in regulation or biosynthesis of electron transport chain components. Involved in the biosynthesis of acetate during anaerobic growth on glucose","reactions":[{"id":1299,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1302,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1321,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2318,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"An aldehyde + NAD(+) + H(2)O = an acid + NADH.","export":false,"pw_reaction_id":null,"source":null},{"id":2325,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"An aldehyde + NADP(+) + H(2)O = an acid + NADPH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"U18814","genbank_protein_id":"603310","gene_card_id":"ALD5","chromosome_location":"chromosome 5","locus":"YER073W","synonyms":[],"enzyme_classes":["1.2.1.3","1.2.1.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Aldedh","identifier":"PF00171"}],"pathways":[],"gene_sequence":"ATGCTTTCTCGCACAAGAGCTGCAGCTCCGAATTCCAGAATATTCACTAGAAGCTTGTTACGTCTTTATTCTCAAGCACCATTACGCGTTCCAATTACTCTTCCAAATGGTTTCACCTACGAACAGCCAACAGGGTTATTCATCAATGGTGAATTTGTTGCCTCGAAGCAAAAGAAAACGTTTGACGTGATCAATCCATCTAACGAAGAAAAGATAACAACTGTATACAAGGCTATGGAAGATGATGTTGATGAAGCCGTTGCAGCGGCTAAAAAAGCTTTTGAAACGAAGTGGTCTATTGTAGAGCCGGAGGTTCGCGCTAAAGCTTTATTCAATCTCGCTGACTTGGTTGAGAAACACCAAGAAACACTGGCTGCCATTGAGTCAATGGATAATGGTAAGTCATTGTTTTGTGCGCGCGGTGACGTCGCTTTAGTATCTAAATACTTGCGTTCTTGCGGTGGTTGGGCAGATAAAATCTACGGTAACGTTATTGACACAGGTAAAAACCATTTTACCTACTCAATTAAGGAACCATTAGGCGTTTGCGGCCAAATAATCCCTTGGAACTTCCCTTTATTGATGTGGTCATGGAAAATTGGGCCTGCTCTGGCTACAGGTAACACCGTCGTATTGAAACCCGCTGAAACAACACCTTTATCTGCCCTTTTCGCTTCCCAGTTGTGTCAGGAAGCAGGCATACCCGCTGGTGTAGTCAATATCCTTCCGGGTTCCGGTAGAGTTGTTGGAGAAAGATTGAGTGCACACCCAGACGTGAAGAAGATTGCTTTTACAGGCTCTACTGCCACCGGCCGCCATATTATGAAGGTCGCTGCCGATACTGTCAAGAAAGTCACTTTGGAGCTGGGAGGTAAATCACCAAATATTGTGTTTGCTGACGCTGATCTAGATAAAGCCGTCAAGAACATTGCCTTCGGTATTTTTTACAACTCTGGTGAAGTTTGCTGCGCTGGTTCCAGAATATACATTCAAGATACAGTATACGAGGAGGTGTTGCAAAAACTAAAGGATTACACCGAGTCACTAAAGGTCGGTGACCCATTTGATGAGGAAGTTTTCCAAGGTGCTCAAACATCTGACAAACAGCTGCATAAAATTTTAGACTATGTCGATGTAGCAAAATCAGAGGGGGCTCGTCTTGTGACTGGAGGGGCCAGACATGGCAGTAAAGGTTATTTTGTCAAGCCAACAGTGTTTGCTGATGTCAAAGGAGATATGAGAATTGTTAAGGAGGAAGTGTTTGGTCCCATTGTAACTGTATCCAAGTTTTCTACTGTTGATGAAGTGATTGCTATGGCAAATGATTCTCAATATGGGTTAGCCGCAGGTATTCACACTAACGATATTAACAAGGCTGTTGATGTGTCCAAAAGAGTGAAAGCTGGTACTGTTTGGATAAATACCTATAACAACTTCCACCAAAATGTTCCTTTCGGTGGCTTCGGCCAGTCAGGTATTGGCCGTGAAATGGGTGAGGCTGCTTTAAGTAACTACACTCAAACAAAATCTGTCAGAATTGCCATTGACAAGCCAATTCGTTGA","protein_sequence":"MLSRTRAAAPNSRIFTRSLLRLYSQAPLRVPITLPNGFTYEQPTGLFINGEFVASKQKKTFDVINPSNEEKITTVYKAMEDDVDEAVAAAKKAFETKWSIVEPEVRAKALFNLADLVEKHQETLAAIESMDNGKSLFCARGDVALVSKYLRSCGGWADKIYGNVIDTGKNHFTYSIKEPLGVCGQIIPWNFPLLMWSWKIGPALATGNTVVLKPAETTPLSALFASQLCQEAGIPAGVVNILPGSGRVVGERLSAHPDVKKIAFTGSTATGRHIMKVAADTVKKVTLELGGKSPNIVFADADLDKAVKNIAFGIFYNSGEVCCAGSRIYIQDTVYEEVLQKLKDYTESLKVGDPFDEEVFQGAQTSDKQLHKILDYVDVAKSEGARLVTGGARHGSKGYFVKPTVFADVKGDMRIVKEEVFGPIVTVSKFSTVDEVIAMANDSQYGLAAGIHTNDINKAVDVSKRVKAGTVWINTYNNFHQNVPFGGFGQSGIGREMGEAALSNYTQTKSVRIAIDKPIR"},{"created_at":"2011-05-24T21:12:04.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Deoxyhypusine 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propane-1,3-diamine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY558282","genbank_protein_id":"45270454","gene_card_id":"DYS1","chromosome_location":"chromosome 8","locus":"YHR068W","synonyms":["DHS"],"enzyme_classes":["2.5.1.46"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" peptidyl-amino acid modification"},{"category":"Process","description":" peptidyl-lysine modification"},{"category":"Process","description":" peptidyl-lysine modification to hypusine"}],"pfams":[{"name":"DS","identifier":"PF01916"}],"pathways":[],"gene_sequence":"ATGTCCGATATCAACGAAAAACTCCCAGAGTTACTACAAGACGCTGTCTTGAAAGCATCTGTTCCTATTCCAGATGACTTCGTTAAGGTTCAAGGTATTGATTACTCAAAGCCTGAAGCCACTAATATGAGAGCAACTGATTTAATTGAAGCTATGAAGACCATGGGTTTCCAAGCTAGTTCTGTTGGTACTGCCTGTGAGATTATTGATAGTATGAGATCATGGAGAGGTAAGCATATTGACGAATTGGATGACCATGAAAAGAAAGGTTGCTTCGATGAGGAAGGGTACCAAAAGACTACTATCTTCATGGGTTATACTTCTAACTTGATCAGTTCCGGTGTACGTGAAACTTTACGTTATTTGGTGCAACACAAAATGGTTGATGCTGTCGTTACTTCTGCTGGTGGTGTGGAAGAAGATTTGATCAAATGTCTTGCTCCAACTTACTTGGGTGAATTTGCTTTGAAAGGTAAATCTTTGCGTGACCAAGGTATGAATCGTATTGGTAACTTGCTTGTTCCAAATGATAACTACTGTAAGTTTGAAGAATGGATTGTCCCAATTTTGGATAAGATGTTGGAAGAACAAGATGAATACGTAAAGAAACATGGCGCTGACTGTTTAGAGGCTAACCAAGACGTGGATTCACCAATCTGGACCCCATCTAAGATGATAGACCGTTTTGGTAAGGAAATCAACGACGAATCCTCCGTATTGTACTGGGCCCACAAGAATAAAATTCCAATCTTTTGTCCATCTTTGACTGATGGTTCAATCGGTGACATGTTGTTTTTCCATACTTTTAAAGCATCTCCAAAACAACTAAGAGTTGACATTGTAGGAGATATCCGCAAAATCAATTCAATGTCCATGGCCGCTTACAGAGCCGGTATGATCATCTTGGGTGGTGGTTTGATCAAGCACCACATTGCCAATGCTTGTTTGATGAGAAATGGTGCTGATTATGCCGTTTACATTAACACTGGTCAAGAATACGATGGTTCTGATGCAGGTGCAAGACCTGACGAAGCTGTGTCTTGGGGTAAGATCAAGGCTGAAGCCAAATCCGTCAAACTTTTTGCTGATGTCACCACTGTTCTTCCATTGATTGTTGCTGCTACCTTTGCCAGTGGTAAACCAATCAAAAAAGTTAAGAATTGA","protein_sequence":"MSDINEKLPELLQDAVLKASVPIPDDFVKVQGIDYSKPEATNMRATDLIEAMKTMGFQASSVGTACEIIDSMRSWRGKHIDELDDHEKKGCFDEEGYQKTTIFMGYTSNLISSGVRETLRYLVQHKMVDAVVTSAGGVEEDLIKCLAPTYLGEFALKGKSLRDQGMNRIGNLLVPNDNYCKFEEWIVPILDKMLEEQDEYVKKHGADCLEANQDVDSPIWTPSKMIDRFGKEINDESSVLYWAHKNKIPIFCPSLTDGSIGDMLFFHTFKASPKQLRVDIVGDIRKINSMSMAAYRAGMIILGGGLIKHHIANACLMRNGADYAVYINTGQEYDGSDAGARPDEAVSWGKIKAEAKSVKLFADVTTVLPLIVAATFASGKPIKKVKN"}]}