{"ymdb_id":"YMDB00195","created_at":"2011-05-29T16:05:45.000Z","updated_at":"2016-09-08T18:35:10.000Z","name":"Beta-Alanine","cas":"107-95-9","state":"Solid","melting_point":"200 oC","description":"beta-Alanine is the only naturally occurring beta-amino acid. It is formed in vivo by the degradation of dihydrouracil and carnosine. It is a component of the naturally occurring peptides carnosine and anserine and also of R-pantothenic acid (vitamin B5) which itself is a component of coenzyme A. Under normal conditions, beta-alanine is metabolized into acetic acid.","experimental_water_solubility":"545 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-3.05 [TSAI,RS ET AL. (1991)]","location":"cytoplasm","synthesis_reference":"Buc, Saul R.; Ford, Jared H.; Wise, E. C. Improved synthesis of b-alanine. Journal of the American Chemical Society (1945), 67 92-4.","chebi_id":"16958","hmdb_id":"HMDB00056","kegg_id":"C00099","pubchem_id":"239","cs_id":"234","foodb_id":null,"wikipedia_link":"Beta-Alanine","biocyc_id":"B-ALANINE","iupac":"3-aminopropanoic acid","traditional_iupac":"β alanine","logp":"-3.173589452576714","pka":null,"alogps_solubility":"4.94e+02 g/l","alogps_logp":"-3.26","alogps_logs":"0.74","acceptor_count":"3","donor_count":"2","rotatable_bond_count":"2","polar_surface_area":"63.32","refractivity":"20.7028","polarizability":"8.617827871827803","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"10.307201201262663","pka_strongest_acidic":"4.084398800362644","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-Carboxyethylamine","3-amino-Propanoate","3-amino-Propanoic acid","3-Aminopropanoate","3-Aminopropanoic acid","3-Aminopropionate","3-Aminopropionic acid","Abufene","B-Alanine","b-Aminopropanoate","b-Aminopropanoic acid","b-Aminopropionate","b-Aminopropionic acid","beta Alanine","beta-Alanine","beta-Aminopropanoate","beta-Aminopropanoic acid","beta-Aminopropionate","beta-Aminopropionic acid","omega-Aminopropionate","omega-Aminopropionic acid"],"pathways":[{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":12586697,"citation":"White, W. H., Skatrud, P. L., Xue, Z., Toyn, J. H. (2003). \"Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae.\" Genetics 163:69-77."},{"pubmed_id":11154694,"citation":"White, W. H., Gunyuzlu, P. L., Toyn, J. H. (2001). \"Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine.\" J Biol Chem 276:10794-10800."}],"proteins":[{"created_at":"2011-05-24T20:24:23.000Z","updated_at":"2011-07-22T17:54:08.000Z","name":"Aldehyde dehydrogenase [NAD(P)+] 1","uniprot_id":"P47771","uniprot_name":"ALDH2_YEAST","enzyme":true,"transporter":false,"gene_name":"ALD2","num_residues":506,"molecular_weight":"55187.39844","theoretical_pi":"5.24","general_function":"Involved in oxidoreductase activity","specific_function":"An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H","reactions":[{"id":1298,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1307,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2315,"direction":"\u003e","locations":"Cytoplasm (Potential)","altext":"An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm (Potential)","genbank_gene_id":"X85987","genbank_protein_id":"758648","gene_card_id":"ALD2","chromosome_location":"chromosome 13","locus":"YMR170C","synonyms":[],"enzyme_classes":["1.2.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Aldedh","identifier":"PF00171"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"}],"gene_sequence":"ATGCCTACCTTGTATACTGATATCGAAATCCCACAATTGAAAATCTCTTTAAAGCAACCGCTAGGGTGTTTTATCAACAATGAGTTTTGTCCATCATCAGATGGAAAGACCATCGAAACTGTGAACCCAGCTACTGGCGAACCGATAACATCCTTCCAAGCAGCTAACGAAAAGGATGTAGACAAAGCTGTGAAAGCTGCCAGGGCTGCTTTTGATAACGTTTGGTCGAAGACATCTTCTGAGCAACGTGGTATTTATCTTTCAAACTTATTAAAACTTATTGAGGAGGAGCAAGACACACTTGCCGCATTAGAGACTTTAGACGCTGGAAAGCCTTACCATTCAAATGCCAAAGGTGATTTGGCACAAATTTTACAGCTTACCAGATATTTTGCTGGGTCCGCTGATAAGTTTGACAAAGGTGCAACCATACCATTGACTTTTAACAAGTTTGCATATACTCTAAAAGTTCCTTTTGGCGTTGTTGCTCAAATCGTTCCATGGAATTATCCTCTAGCTATGGCTTGTTGGAAATTGCAAGGTGCCTTAGCAGCCGGTAACACGGTTATCATCAAACCTGCTGAGAATACCTCTCTATCTCTACTTTATTTTGCTACTTTAATTAAAAAAGCAGGTTTTCCACCTGGTGTTGTCAATATCGTTCCTGGTTATGGATCACTTGTAGGCCAAGCCCTAGCATCTCACATGGATATCGACAAAATATCTTTTACGGGAAGCACCAAGGTCGGTGGATTTGTGTTGGAAGCTTCCGGCCAATCGAACCTTAAAGACGTTACACTAGAATGCGGTGGTAAGTCTCCTGCTCTCGTATTTGAAGATGCAGACCTTGATAAGGCTATCGATTGGATAGCAGCTGGCATTTTCTACAATTCAGGACAGAATTGTACCGCAAACTCAAGAGTTTATGTTCAAAGTTCGATCTACGACAAGTTTGTTGAAAAGTTTAAAGAAACTGCAAAGAAGGAGTGGGATGTTGCAGGAAAATTTGATCCGTTTGATGAGAAATGCATCGTTGGTCCAGTTATATCAAGTACACAGTATGACCGCATCAAAAGTTACATAGAACGTGGTAAAAGGGAGGAAAAGTTGGACATGTTCCAGACCTCTGAATTTCCTATTGGTGGAGCTAAAGGCTACTTCATTCCCCCAACCATCTTCACTGATGTCCCGCAAACATCGAAACTGTTACAGGATGAGATATTTGGCCCGGTTGTGGTTGTTAGCAAGTTCACAAATTATGATGACGCTCTGAAGCTGGCTAATGATACTTGCTACGGGCTCGCCTCTGCGGTCTTCACAAAAGATGTCAAGAAAGCGCACATGTTTGCTCGCGATATTAAAGCAGGAACTGTTTGGATCAATCAATCTAACGATGAAGATGTTACCGTTCCTTTTGGCGGGTTTAAGATGAGTGGTATTGGTAGAGAACTAGGCGACAACGTCGTTGATACCTATCTACAAACAAAATCAGTTCACATGGATCTCTCTTTGGACAACTAA","protein_sequence":"MPTLYTDIEIPQLKISLKQPLGLFINNEFCPSSDGKTIETVNPATGEPITSFQAANEKDVDKAVKAARAAFDNVWSKTSSEQRGIYLSNLLKLIEEEQDTLAALETLDAGKPYHSNAKGDLAQILQLTRYFAGSADKFDKGATIPLTFNKFAYTLKVPFGVVAQIVPWNYPLAMACWKLQGALAAGNTVIIKPAENTSLSLLYFATLIKKAGFPPGVVNIVPGYGSLVGQALASHMDIDKISFTGSTKVGGFVLEASGQSNLKDVTLECGGKSPALVFEDADLDKAIDWIAAGIFYNSGQNCTANSRVYVQSSIYDKFVEKFKETAKKEWDVAGKFDPFDEKCIVGPVISSTQYDRIKSYIERGKREEKLDMFQTSEFPIGGAKGYFIPPTIFTDVPQTSKLLQDEIFGPVVVVSKFTNYDDALKLANDTCYGLASAVFTKDVKKAHMFARDIKAGTVWINSSNDEDVTVPFGGFKMSGIGRELGQSGVDTYLQTKAVHINLSLDN"},{"created_at":"2011-05-24T20:27:52.000Z","updated_at":"2011-07-22T17:54:08.000Z","name":"Aldehyde dehydrogenase [NAD(P)+] 2","uniprot_id":"P54114","uniprot_name":"ALDH3_YEAST","enzyme":true,"transporter":false,"gene_name":"ALD3","num_residues":506,"molecular_weight":"55384.80078","theoretical_pi":"5.42","general_function":"Involved in oxidoreductase activity","specific_function":"An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H","reactions":[{"id":1298,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1307,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2315,"direction":"\u003e","locations":"Cytoplasm (Potential)","altext":"An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null},{"id":3763,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006287","source":"Smpdb"},{"id":3764,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006418","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z49705","genbank_protein_id":"825574","gene_card_id":"ALD3","chromosome_location":"chromosome 13","locus":"YMR169C","synonyms":[],"enzyme_classes":["1.2.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Aldedh","identifier":"PF00171"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Histidine metabolism","kegg_map_id":"00340"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Glycerol metabolism","kegg_map_id":null}],"gene_sequence":"ATGCCTACCTTGTATACTGATATCGAAATCCCACAATTGAAAATCTCTTTAAAGCAACCGCTAGGGTTGTTTATCAACAATGAGTTTTGTCCATCATCAGATGGAAAGACCATCGAAACTGTGAACCCAGCTACTGGCGAACCGATAACATCCTTCCAAGCAGCTAACGAAAAGGATGTAGACAAAGCTGTGAAAGCTGCCAGGGCTGCTTTTGATAACGTTTGGTCGAAGACATCTTCTGAGCAACGTGGTATTTATCTTTCAAACTTATTAAAACTTATTGAGGAGGAGCAAGACACACTTGCCGCATTAGAGACTTTAGACGCTGGTAAGCCTTTCCATTCCAATGCTAAACAAGACTTAGCCCAGATTATAGAACTTACAAGATACTATGCGGGGGCGGTCGACAAGTTCAATATGGGTGAAACCATTCCATTGACTTTTAACAAGTTTGCATATACTCTAAAAGTTCCTTTTGGCGTTGTTGCTCAAATCGTTCCATGGAATTATCCTCTAGCTATGGCTTGTAGAAAAATGCAAGGTGCCTTAGCGGCCGGTAACACGGTTATCATCAAACCTGCTGAAAATACCTCTCTATCTCTACTTTATTTTGCTACTTTAATTAAAAAAGCAGGTTTTCCACCTGGTGTTGTCAATGTCATTCCTGGTTATGGTTCCGTTGTGGGGAAAGCTTTAGGAACCCACATGGATATCGACAAAATATCTTTTACGGGAAGTACTAAGGTTGGCGGCTCAGTATTGGAAGCTTCCGGCCAATCGAACCTTAAGGATATCACACTAGAATGCGGTGGTAAGTCTCCTGCTCTTGTATTTGAAGATGCAGACCTTGATAAGGCTATAGAATGGGTAGCAAATGGTATTTTTTTTAATTCGGGACAGATCTGCACTGCAAACTCAAGAGTTTATGTTCAAAGTTCGATCTACGACAAGTTTGTTGAAAAGTTTAAAGAAACTGCAAAGAAGGAGTGGGATGTTGCAGGAAAATTTGATCCGTTTGATGAGAAATGCATCGTTGGTCCAGTTATATCAAGTACACAGTATGACCGCATCAAAAGTTACATAGAACGTGGTAAAAAGGAGGAAAAGTTGGACATGTTCCAGACCTCTGAATTTCCTATTGGTGGAGCTAAAGGCTACTTCATTCCCCCAACCATCTTCACTGATGTACCAGAAACATCTAAGTTGCTGCGTGATGAAATATTTGGCCCGGTTGTGGTTGTTAGCAAGTTCACAAATTATGATGACGCTCTGAAGCTGGCTAATGATACTTGCTACGGGCTCGCCTCTGCGGTCTTCACCAAAGATGTCAAGAAAGCGCACATGTTTGCTCGCGATATTAAAGCAGGAACTGTTTGGATCAATCAAACCAATCAAGAAGAAGCTAAAGTTCCTTTTGGCGGATTTAAGATGAGTGGTATTGGTAGAGAATCAGGCGACACCGGCGTTGATAACTATTTACAAATAAAATCAGTCCATGTGGATCTTTCATTGGATAAATAA","protein_sequence":"MPTLYTDIEIPQLKISLKQPLGLFINNEFCPSSDGKTIETVNPATGEPITSFQAANEKDVDKAVKAARAAFDNVWSKTSSEQRGIYLSNLLKLIEEEQDTLAALETLDAGKPFHSNAKQDLAQIIELTRYYAGAVDKFNMGETIPLTFNKFAYTLKVPFGVVAQIVPWNYPLAMACRKMQGALAAGNTVIIKPAENTSLSLLYFATLIKKAGFPPGVVNVIPGYGSVVGKALGTHMDIDKISFTGSTKVGGSVLEASGQSNLKDITLECGGKSPALVFEDADLDKAIEWVANGIFFNSGQICTANSRVYVQSSIYDKFVEKFKETAKKEWDVAGKFDPFDEKCIVGPVISSTQYDRIKSYIERGKKEEKLDMFQTSEFPIGGAKGYFIPPTIFTDVPETSKLLRDEIFGPVVVVSKFTNYDDALKLANDTCYGLASAVFTKDVKKAHMFARDIKAGTVWINQTNQEEAKVPFGGFKMSGIGRESGDTGVDNYLQIKSVHVDLSLDK"},{"created_at":"2011-05-27T05:45:58.000Z","updated_at":"2011-05-29T05:06:42.000Z","name":"Glutamate decarboxylase","uniprot_id":"Q04792","uniprot_name":"DCE_YEAST","enzyme":true,"transporter":false,"gene_name":"GAD1","num_residues":585,"molecular_weight":"65989.5","theoretical_pi":"6.61","general_function":"Involved in glutamate decarboxylase activity","specific_function":"L-glutamate = 4-aminobutanoate + CO(2)","reactions":[{"id":1571,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2782,"direction":"\u003e","locations":null,"altext":"L-glutamate = 4-aminobutanoate + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3747,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006274","source":"Smpdb"},{"id":3748,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006857","source":"Smpdb"},{"id":3749,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006858","source":"Smpdb"},{"id":14214,"direction":null,"locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006653","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z48639","genbank_protein_id":"732928","gene_card_id":"GAD1","chromosome_location":"chromosome 13","locus":"YMR250W","synonyms":["GAD"],"enzyme_classes":["4.1.1.15"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" glutamate decarboxylase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" glutamate metabolic process"}],"pfams":[{"name":"Pyridoxal_deC","identifier":"PF00282"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Taurine and hypotaurine metabolism","kegg_map_id":"00430"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Glutamate Metabolism","kegg_map_id":null},{"name":"Taurine and hypotaurine biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTTACACAGGCACGGTTCTAAGCAGAAGAACTTCGAGAATATCGCTGGAAAAGTTGTCCACGACCTTGCAGGTCTGCAATTGCTTTCTAACGACGTTCAAAAATCCGCTGTCCAAAGTGGTCATCAAGGATCGAACAATATGAGAGATACTTCGTCTCAGGGCATGGCTAATAAGTATTCAGTTCCAAAAAAGGGACTACCTGCTGATTTGTCTTACCAACTGATTCATAATGAATTAACACTTGATGGTAATCCGCATTTGAACCTTGCCAGTTTCGTGAACACTTTTACCACTGATCAGGCAAGGAAATTGATTGATGAAAATTTGACCAAAAATCTTGCTGACAATGATGAATATCCGCAATTAATTGAGCTAACTCAGCGTTGTATTTCTATGCTAGCTCAATTATGGCACGCTAATCCCGATGAAGAACCAATAGGCTGTGCCACCACAGGTTCTAGTGAGGCAATCATGTTGGGTGGACTCGCCATGAAAAAAAGATGGGAACACAGAATGAAGAATGCTGGTAAAGATGCTTCCAAGCCGAACATTATAATGTCTTCTGCGTGCCAAGTGGCATTAGAGAAGTTTACGAGATATTTTGAAGTGGAATGCCGATTGGTTCCGGTATCCCACAGAAGCCATCATATGCTTGACCCAGAGTCGTTATGGGATTATGTAGATGAGAACACTATTGGCTGTTTTGTAATTTTAGGAACCACCTACACTGGCCATTTGGAAAATGTAGAGAAAGTTGCAGATGTCTTGTCCCAAATTGAGGCCAAGCATCCTGATTGGAGCAATACTGATATTCCAATCCATGCGGATGGCGCTTCAGGTGGGTTTATTATCCCATTTGGCTTTGAAAAAGAGCACATGAAAGCTTATGGCATGGAACGTTGGGGGTTCAACCATCCGCGTGTGGTTAGTATGAACACTAGTGGTCATAAGTTTGGCTTAACCACTCCCGGTCTGGGTTGGGTGCTATGGAGAGATGAATCCTTACTGGCTGATGAATTGAGATTCAAACTAAAGTACCTCGGTGGCGTGGAAGAAACTTTCGGTTTGAATTTTTCAAGACCTGGATTTCAAGTTGTCCATCAATACTTCAATTTTGTTTCTCTAGGCCATTCAGGGTATAGAACACAATTCCAAAATTCTCTATTTGTTGCAAGAGCGTTTTCTTTCGAATTATTGAATTCGTCAAAATTGCCCGGATGCTTTGAAATTGTTAGCAGTATCCATGAAAGCATTGAGAACGATTCCGCCCCTAAGTCAGTTAAAGACTATTGGGAACACCCCCAGGCTTACAAACCAGGTGTACCGCTGGTAGCCTTCAAATTGTCCAAGAAATTCCACGAAGAATATCCAGAAGTGCCACAAGCAATCCTTTCCTCTTTACTGAGAGGTAGGGGTTGGATAATACCAAATTACCCACTACCAAAGGCAACGGATGGATCCGATGAGAAGGAGGTATTAAGAGTGGTTTTCAGATCGGAGATGAAGTTGGATTTAGCACAGTTGTTGATCGTTGACATCGAGAGTATCTTGACAAAGTTGATTCATAGTTACGAAAAGGTTTGTCATCATATAGAACTTGCCTCTGAGCAAACTCCAGAGCGCAAGAGTTCGTTCATCTACGAAATGTTGCTGGCATTGGCATCTCCACAAGATGACATCCCAACGCCGGATGAAATCGAAAAGAAAAATAAGCTAAAGGAAACAACAACGAGAAACTATAGAGGAACATGTTGA","protein_sequence":"MLHRHGSKQKNFENIAGKVVHDLAGLQLLSNDVQKSAVQSGHQGSNNMRDTSSQGMANKYSVPKKGLPADLSYQLIHNELTLDGNPHLNLASFVNTFTTDQARKLIDENLTKNLADNDEYPQLIELTQRCISMLAQLWHANPDEEPIGCATTGSSEAIMLGGLAMKKRWEHRMKNAGKDASKPNIIMSSACQVALEKFTRYFEVECRLVPVSHRSHHMLDPESLWDYVDENTIGCFVILGTTYTGHLENVEKVADVLSQIEAKHPDWSNTDIPIHADGASGGFIIPFGFEKEHMKAYGMERWGFNHPRVVSMNTSGHKFGLTTPGLGWVLWRDESLLADELRFKLKYLGGVEETFGLNFSRPGFQVVHQYFNFVSLGHSGYRTQFQNSLFVARAFSFELLNSSKLPGCFEIVSSIHESIENDSAPKSVKDYWEHPQAYKPGVPLVAFKLSKKFHEEYPEVPQAILSSLLRGRGWIIPNYPLPKATDGSDEKEVLRVVFRSEMKLDLAQLLIVDIESILTKLIHSYEKVCHHIELASEQTPERKSSFIYEMLLALASPQDDIPTPDEIEKKNKLKETTTRNYRGTC"},{"created_at":"2011-05-29T04:13:02.000Z","updated_at":"2011-05-29T05:06:53.000Z","name":"Pantoate--beta-alanine ligase","uniprot_id":"P40459","uniprot_name":"PANC_YEAST","enzyme":true,"transporter":false,"gene_name":"PAN6","num_residues":309,"molecular_weight":"35031.89844","theoretical_pi":"5.08","general_function":"Involved in pantoate-beta-alanine ligase activity","specific_function":"Required for pantothenic acid biosynthesis","reactions":[{"id":1831,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2841,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.","export":false,"pw_reaction_id":null,"source":null},{"id":3765,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006288","source":"Smpdb"},{"id":14219,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006656","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"PAN6","chromosome_location":"chromosome 9","locus":"YIL145C","synonyms":["Pantoate-activating enzyme","Pantothenate synthetase"],"enzyme_classes":["6.3.2.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" acid-amino acid ligase activity"},{"category":"Function","description":" pantoate-beta-alanine ligase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" pantothenate biosynthetic process"}],"pfams":[{"name":"Pantoate_ligase","identifier":"PF02569"}],"pathways":[{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"}],"gene_sequence":"ATGAAAATCTTCCATACTGTCGAAGAAGTTGTTCAATGGAGAACACAGGAGCTGAGGGAAACTAGATTTAGAGAAACTATTGGGTTCGTTCCCACAATGGGTTGCCTGCATTCGGGTCACGCTAGTTTGATCTCGCAGTCTGTGAAGGAAAACACCTATACTGTGGTCAGTATATTTGTAAATCCCTCCCAGTTTGCGCCAACGGAAGATCTAGATAACTATCCTCGAACTTTGCCAGACGACATCAAATTGCTTGAGTCGTTGAAGGTGGATGTTCTATTTGCTCCTAATGCACACGTGATGTATCCACAGGGAATTCCGCTCGACATAGAAGAGCAGAAAGGCCCTTTTGTTAGTGTTCTTGGATTGAGTGAAAAATTAGAGGGGAAGACGAGACCTAACTTCTTTAGGGGCGTGGCAACTGTCGTGACTAAACTATTCAATATCGTTATGGCGGATGTGGCTTATTTTGGGCAGAAGGACATTCAACAGTTCATTGTTTTACAGTGTATGGTGGACGAACTGTTTGTTAATACAAGGCTACAAATGATGCCTATTGTAAGAAACAATAATGGACTGGCTCTGAGTAGTAGAAACAAATATCTTTGTCCAGAGTCTTTAAAGATCTCTGAAAACCTTTACCGCGGGCTGAAAGCTGCGGAAAATGCTATTAGGAGACTAGCACCAGGGGGACGTCTCTCCAGATCAGAAATCATCGATACTGTGACTCAAATATGGGCACCCTACGTTGATTCCCACGATTTCAAAATCGACTATGTTTCCTTAGCAGATTTTAAGACTCTTGATGAACTCTCCGATGTTGAAAACACCAGCGAACAGCAGCCAATAGTCATTAGTTGTGCTGTATACGTGACTGACCGCGAAAAACCCGATACGGTCGTCAGACTAATAGATAACATCGTTATTTAA","protein_sequence":"MKIFHTVEEVVQWRTQELRETRFRETIGFVPTMGCLHSGHASLISQSVKENTYTVVSIFVNPSQFAPTEDLDNYPRTLPDDIKLLESLKVDVLFAPNAHVMYPQGIPLDIEEQKGPFVSVLGLSEKLEGKTRPNFFRGVATVVTKLFNIVMADVAYFGQKDIQQFIVLQCMVDELFVNTRLQMMPIVRNNNGLALSSRNKYLCPESLKISENLYRGLKAAENAIRRLAPGGRLSRSEIIDTVTQIWAPYVDSHDFKIDYVSLADFKTLDELSDVENTSEQQPIVISCAVYVTDREKPDTVVRLIDNIVI"}]}