{"ymdb_id":"YMDB00514","created_at":"2011-05-29T18:25:27.000Z","updated_at":"2016-09-08T18:35:34.000Z","name":"Succinyl-CoA","cas":"604-98-8","state":"Solid","melting_point":"","description":"Succinyl-CoA is an important intermediate in the citric acid cycle, where it is synthesized from alpha-ketoglutarate by alpha-ketoglutarate dehydrogenase [EC 1.2.4.2] through decarboxylation. It is then converted into succinate through the hydrolytic release of coenzyme A by succinyl-CoA synthetase [EC 6.2.1.5].","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"mitochondrion;lipid particle;endoplasmic reticulum","synthesis_reference":"Wollemann, M.  Mechanism of the succinyl-coenzyme A synthesis in brain extracts.    Acta Physiologica Academiae Scientiarum Hungaricae  (1959),  16  153-4. ","chebi_id":"15380","hmdb_id":"HMDB01022","kegg_id":"C00091","pubchem_id":"439161","cs_id":"24785295","foodb_id":null,"wikipedia_link":"Succinyl-CoA","biocyc_id":"3-METHYLBENZYLSUCCINYL-COA","iupac":"4-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-4-oxobutanoic acid","traditional_iupac":"succinyl-coa","logp":"-6.057050251482925","pka":"1.8959580727344818","alogps_solubility":"3.84e+00 g/l","alogps_logp":"-0.61","alogps_logs":"-2.35","acceptor_count":"19","donor_count":"10","rotatable_bond_count":"23","polar_surface_area":"400.9299999999999","refractivity":"183.10130000000004","polarizability":"77.46085733350095","formal_charge":"0","physiological_charge":"-5","pka_strongest_basic":"4.243758965904162","pka_strongest_acidic":"0.8205988627442897","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["CoA S-(hydrogen succinate)","CoA S-succinate","Coenzyme A S-(hydrogen succinate)","Coenzyme A S-succinate","S-(hydrogen butanedioate","S-(hydrogen butanedioate) CoA","S-(hydrogen butanedioate) Coenzyme A","S-(hydrogen butanedioic acid","S-Succinoylcoenzyme A","suc-co-A","suc-coa","succ-CoA","succ-Coenzyme A","succ-coenzyme-A","succ-S-CoA","succ-S-Coenzyme A","succ-S-coenzyme-A","succino-1-yl-coenzyme a","Succinyl CoA","Succinyl coenzyme A","succinyl-S-CoA","succinyl-S-Coenzyme A","succinyl-S-coenzyme-A","succinylcoenzyme-A"],"pathways":[{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Citric Acid Cycle","kegg_map_id":null},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"Porphyrin Metabolism","kegg_map_id":null},{"name":"Sphingolipid metabolism","kegg_map_id":"00600"},{"name":"TCA Cycle","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":8234090,"citation":"Chelstowska, A., Rytka, J. (1993). \"[Biosynthesis of heme in yeast Saccharomyces cerevisiae].\" Postepy Biochem 39:173-185."},{"pubmed_id":14559249,"citation":"Hoffman, M., Gora, M., Rytka, J. (2003). \"Identification of rate-limiting steps in yeast heme biosynthesis.\" Biochem Biophys Res Commun 310:1247-1253."},{"pubmed_id":2178788,"citation":"Ruttkay-Nedecky, B., Subik, J. (1990). \"The OGD1 gene, affecting 2-oxoglutarate dehydrogenase in S. cerevisiae, is closely linked to HIS5 on chromosome IX.\" Curr Genet 17:85-88."},{"pubmed_id":10224250,"citation":"Przybyla-Zawislak, B., Gadde, D. M., Ducharme, K., McCammon, M. T. (1999). \"Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes.\" Genetics 152:153-166."},{"pubmed_id":9874242,"citation":"Przybyla-Zawislak, B., Dennis, R. A., Zakharkin, S. O., McCammon, M. T. (1998). \"Genes of succinyl-CoA ligase from Saccharomyces cerevisiae.\" Eur J Biochem 258:736-743."}],"proteins":[{"created_at":"2011-05-24T20:09:37.000Z","updated_at":"2011-07-22T17:53:50.000Z","name":"5-aminolevulinate synthase, mitochondrial","uniprot_id":"P09950","uniprot_name":"HEM1_YEAST","enzyme":true,"transporter":false,"gene_name":"HEM1","num_residues":548,"molecular_weight":"59361.69922","theoretical_pi":"7.56","general_function":"Involved in 5-aminolevulinate synthase activity","specific_function":"Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2)","reactions":[{"id":1213,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2301,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"M26329","genbank_protein_id":"171662","gene_card_id":"HEM1","chromosome_location":"chromosome 4","locus":"YDR232W","synonyms":["5-aminolevulinic acid synthase","Delta-ALA synthase","Delta-aminolevulinate synthase"],"enzyme_classes":["2.3.1.37"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" N-acyltransferase activity"},{"category":"Function","description":" N-succinyltransferase activity"},{"category":"Function","description":" 5-aminolevulinate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" tetrapyrrole biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular biosynthetic process"},{"category":"Process","description":" heterocycle biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Porphyrin and chlorophyll metabolism","kegg_map_id":"00860"},{"name":"Biosynthesis of unsaturated fatty acids (docosanoyl)","kegg_map_id":null},{"name":"Biosynthesis of unsaturated fatty acids (tetracosanoyl-CoA)","kegg_map_id":null}],"gene_sequence":"ATGCAACGCTCCATTTTTGCGAGGTTCGGTAACTCCTCTGCCGCTGTTTCCACACTGAATAGGCTGTCCACGACAGCCGCACCACATGCGAAAAATGGCTATGCCACCGCTACTGGTGCTGGTGCCGCTGCTGCCACTGCCACAGCGTCATCAACACATGCAGCAGCAGCAGCAGCCGCTGCTGCCAACCATTCCACCCAGGAGTCGGGTTTCGATTACGAAGGCCTGATAGATTCCGAACTGCAGAAGAAAAGACTTGACAAATCGTACAGATATTTCAACAATATCAACCGATTGGCCAAGGAGTTCCCCCTAGCTCATCGCCAGAGAGAGGCGGACAAGGTCACCGTTTGGTGTTCCAACGACTATTTAGCACTTTCCAAGCACCCTGAGGTATTGGACGCCATGCATAAAACTATCGACAAGTATGGTTGTGGTGCCGGTGGTACAAGAAACATTGCTGGCCATAACATCCCCACTTTGAATCTGGAAGCCGAATTGGCCACTTTACACAAGAAGGAAGGTGCCTTAGTTTTTTCGTCATGTTACGTAGCCAACGATGCCGTCTTATCCCTACTGGGTCAAAAGATGAAGGACTTGGTGATTTTCTCCGACGAACTCAACCATGCGTCCATGATTGTCGGTATTAAGCATGCTAACGTAAAAAAACACATTTTCAAACATAATGACTTGAACGAATTGGAACAACTGCTCCAGTCATACCCCAAATCCGTTCCTAAACTAATTGCTTTCGAATCAGTATATTCTATGGCCGGTTCAGTGGCCGACATAGAAAAAATTTGCGACTTGGCCGACAAATACGGTGCTTTGACCTTCTTGGATGAAGTACATGCGGTCGGCCTGTACGGCCCTCACGGTGCAGGTGTTGCAGAACATTGTGATTTTGAAAGTCACCGTGCAAGTGGTATTGCTACCCCAAAGACCAATGACAAGGGCGGCGCGAAGACTGTGATGGACCGTGTCGACATGATCACCGGCACTTTAGGTAAGTCTTTCGGTAGCGTAGGTGGCTACGTCGCAGCCTCTAGGAAATTGATCGATTGGTTCAGATCGTTTGCACCTGGTTTCATTTTCACCACGACTTTACCACCTTCAGTTATGGCAGGCGCTACCGCAGCAATTAGATACCAACGTTGCCACATCGACCTAAGAACCTCGCAACAGAAACATACCATGTACGTAAAGAAAGCTTTCCATGAGTTGGGCATTCCAGTTATTCCAAATCCTTCTCATATCGTCCCAGTGTTGATTGGTAATGCTGATTTGGCTAAGCAAGCTTCTGACATCTTAATCAATAAGCATCAAATCTACGTACAAGCTATCAACTTCCCTACGGTTGCTCGCGGTACCGAAAGATTGAGAATTACCCCAACGCCAGGTCACACCAACGATTTATCTGACATCTTAATCAATGCAGTTGATGATGTGTTCAATGAGCTACAGTTACCACGTGTCAGAGACTGGGAAAGCCAAGGTGGCTTATTGGGTGTTGGAGAGAGCGGATTTGTGGAAGAGTCTAACTTATGGACATCAAGCCAACTATCTTTAACTAATGACGACTTGAACCCTAATGTTAGAGACCCCATCGTTAAACAACTAGAGGTTTCTAGTGGTATCAAGCAGTAA","protein_sequence":"MQRSIFARFGNSSAAVSTLNRLSTTAAPHAKNGYATATGAGAAAATATASSTHAAAAAAAAANHSTQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNELQLPRVRDWESQGGLLGVGESGFVEESNLWTSSQLSLTNDDLNPNVRDPIVKQLEVSSGIKQ"},{"created_at":"2011-05-24T20:14:31.000Z","updated_at":"2011-05-27T14:56:00.000Z","name":"Dihydrolipoyl dehydrogenase, mitochondrial","uniprot_id":"P09624","uniprot_name":"DLDH_YEAST","enzyme":true,"transporter":false,"gene_name":"LPD1","num_residues":499,"molecular_weight":"54009.69922","theoretical_pi":"8.22","general_function":"Involved in oxidoreductase activity","specific_function":"Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine","reactions":[{"id":2306,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1V59","cellular_location":"Mitochondrion matrix","genbank_gene_id":"D50617","genbank_protein_id":"836736","gene_card_id":"LPD1","chromosome_location":"chromosome 6","locus":"YFL018C","synonyms":["Dihydrolipoamide dehydrogenase","Glycine decarboxylase complex subunit L","Lipoamide dehydrogenase component of pyruvate dehydrogenase complex","Pyruvate dehydrogenase complex E3 component"],"enzyme_classes":["1.8.1.4"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on NADH or NADPH"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" dihydrolipoyl dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cell redox homeostasis"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"}],"pfams":[{"name":"Pyr_redox","identifier":"PF00070"},{"name":"Pyr_redox_2","identifier":"PF07992"},{"name":"Pyr_redox_dim","identifier":"PF02852"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"}],"gene_sequence":"ATGTTAAGAATCAGATCACTCCTAAATAATAAGCGTGCCTTTTCGTCCACAGTCAGGACATTGACCATTAACAAGTCACATGATGTAGTCATCATCGGTGGTGGCCCTGCTGGTTACGTGGCTGCTATCAAAGCTGCTCAATTGGGATTTAACACTGCATGTGTAGAAAAAAGAGGCAAATTAGGCGGTACCTGTCTTAACGTTGGATGTATCCCCTCCAAAGCACTTCTAAATAATTCTCATTTATTCCACCAAATGCATACGGAAGCGCAAAAGAGAGGTATTGACGTCAACGGTGATATCAAAATTAACGTAGCAAACTTCCAAAAGGCTAAGGATGACGCTGTTAAGCAATTAACTGGAGGTATTGAGCTTCTGTTCAAGAAAAATAAGGTCACCTATTATAAAGGTAATGGTTCATTCGAAGACGAAACGAAGATCAGAGTAACTCCCGTTGATGGGTTGGAAGGCACTGTCAAGGAAGACCACATACTAGATGTTAAGAACATCATAGTCGCCACGGGCTCTGAAGTTACACCCTTCCCCGGTATTGAAATAGATGAGGAAAAAATTGTCTCTTCAACAGGTGCTCTTTCGTTAAAGGAAATTCCCAAAAGATTAACCATCATTGGTGGAGGAATCATCGGATTGGAAATGGGTTCAGTTTACTCTAGATTAGGCTCCAAGGTTACTGTAGTAGAATTTCAACCTCAAATTGGTGCATCTATGGACGGCGAGGTTGCCAAAGCCACCCAAAAGTTCTTGAAAAAGCAAGGTTTGGACTTCAAATTAAGCACCAAAGTTATTTCTGCAAAGAGAAACGACGACAAGAACGTCGTCGAAATTGTTGTAGAAGATACTAAAACGAATAAGCAAGAAAATTTGGAAGCTGAAGTTTTGCTGGTTGCTGTTGGTAGAAGACCTTACATTGCTGGCTTAGGGGCTGAAAAGATTGGATTAGAAGTAGACAAAAGGGGACGCCTAGTCATTGATGACCAATTTAATTCCAAGTTCCCACACATTAAAGTGGTAGGAGATGTTACATTTGGTCCAATGCTGGCTCACAAAGCCGAAGAGGAAGGTATTGCAGCTGTCGAAATGTTGAAAACTGGTCACGGTCATGTCAACTATAACAACATTCCTTCGGTCATGTATTCTCACCCAGAAGTAGCATGGGTTGGTAAAACCGAAGAGCAATTGAAAGAAGCCGGCATTGACTATAAAATTGGTAAGTTCCCCTTTGCGGCCAATTCAAGAGCCAAGACCAACCAAGACACTGAAGGTTTCGTGAAGATTTTGATCGATTCCAAGACCGAGCGTATTTTGGGGGCTCACATTATCGGTCCAAATGCCGGTGAAATGATTGCTGAAGCTGGCTTAGCCTTAGAATATGGCGCTTCCGCAGAAGATGTTGCTAGGGTCTGCCATGCTCATCCTACTTTGTCCGAAGCATTTAAGGAAGCTAACATGGCTGCCTATGATAAAGCTATTCATTGTTGA","protein_sequence":"MLRIRSLLNNKRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC"},{"created_at":"2011-05-24T21:16:20.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial","uniprot_id":"P53598","uniprot_name":"SUCA_YEAST","enzyme":true,"transporter":false,"gene_name":"LSC1","num_residues":329,"molecular_weight":"35032.19922","theoretical_pi":"8.76","general_function":"Involved in catalytic activity","specific_function":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA","reactions":[{"id":2376,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":3700,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003283","source":"Smpdb"},{"id":3701,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006825","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"X94335","genbank_protein_id":"1164984","gene_card_id":"LSC1","chromosome_location":"chromosome 15","locus":"YOR142W","synonyms":["Succinyl-CoA synthetase subunit alpha","SCS-alpha"],"enzyme_classes":["6.2.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer"},{"category":"Function","description":" ligase activity, forming carbon-sulfur bonds"},{"category":"Function","description":" CoA-ligase activity"},{"category":"Function","description":" succinate-CoA ligase activity"},{"category":"Function","description":" succinate-CoA ligase (ADP-forming) activity"},{"category":"Function","description":" ATP citrate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"CoA_binding","identifier":"PF02629"},{"name":"Ligase_CoA","identifier":"PF00549"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTTAAGATCTACCGTTTCAAAAGCTTCTCTCAAAATTTGTCGTCACTTTCACAGAGAATCTATTCCTTACGATAAGACGATCAAAAATTTGCTGCTTCCCAAGGACACCAAGGTGATCTTTCAGGGGTTCACAGGTAAACAAGGTACTTTTCATGCCAGCATCTCTCAAGAATATGGTACAAATGTTGTGGGTGGTACGAACCCAAAAAAGGCGGGTCAAACACATTTAGGCCAACCTGTCTTTGCCTCTGTGAAGGACGCGATTAAGGAGACTGGAGCCACTGCCAGTGCCATCTTTGTTCCTCCACCGATCGCAGCTGCTGCCATTAAAGAATCTATTGAAGCTGAAATTCCGTTAGCTGTATGTATCACTGAAGGTATTCCTCAACATGACATGTTATACATTGCAGAAATGTTGCAGACACAAGATAAAACAAGATTAGTTGGGCCCAACTGCCCTGGTATCATTAACCCAGCAACAAAGGTAAGAATTGGTATCCAGCCCCCAAAAATTTTTCAAGCTGGTAAAATCGGTATTATTTCCAGATCGGGAACTTTGACATACGAAGCTGTTCAGCAAACTACAAAAACTGACCTTGGTCAATCACTGGTTATTGGTATGGGTGGTGATGCTTTTCCCGGTACTGATTTTATTGACGCCTTGAAATTATTTCTAGAAGATGAAACTACAGAAGGTATTATTATGTTAGGTGAAATAGGTGGTAAGGCCGAAATCGAAGCTGCTCAATTTCTCAAAGAATACAACTTTAGCAGGAGTAAGCCGATGCCGGTGGCATCTTTCATCGCAGGAACTGTTGCTGGTCAAATGAAAGGTGTTAGAATGGGTCACTCCGGTGCAATTGTAGAAGGATCTGGAACTGATGCAGAATCCAAAAAACAAGCTTTGAGAGATGTTGGTGTTGCCGTCGTTGAATCTCCAGGTTACTTAGGTCAAGCTTTACTGGATCAATTTGCCAAATTTAAATGA","protein_sequence":"MLRSTVSKASLKICRHFHRESIPYDKTIKNLLLPKDTKVIFQGFTGKQGTFHASISQEYGTNVVGGTNPKKAGQTHLGQPVFASVKDAIKETGATASAIFVPPPIAAAAIKESIEAEIPLAVCITEGIPQHDMLYIAEMLQTQDKTRLVGPNCPGIINPATKVRIGIQPPKIFQAGKIGIISRSGTLTYEAVQQTTKTDLGQSLVIGMGGDAFPGTDFIDALKLFLEDETTEGIIMLGEIGGKAEIEAAQFLKEYNFSRSKPMPVASFIAGTVAGQMKGVRMGHSGAIVEGSGTDAESKKQALRDVGVAVVESPGYLGQALLDQFAKFK"},{"created_at":"2011-05-24T21:23:08.000Z","updated_at":"2011-05-27T15:00:58.000Z","name":"Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial","uniprot_id":"P19262","uniprot_name":"ODO2_YEAST","enzyme":true,"transporter":false,"gene_name":"KGD2","num_residues":463,"molecular_weight":"50430.30078","theoretical_pi":"9.44","general_function":"Involved in acyltransferase activity","specific_function":"The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)","reactions":[{"id":2384,"direction":"\u003e","locations":"Mitochondrion","altext":"Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-succinyldihydrolipoyl)lysine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"Z50046","genbank_protein_id":"899398","gene_card_id":"KGD2","chromosome_location":"chromosome 4","locus":"YDR148C","synonyms":["2-oxoglutarate dehydrogenase complex component E2","OGDC-E2","Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex"],"enzyme_classes":["2.3.1.61"],"go_classes":[{"category":"Component","description":" oxoglutarate dehydrogenase complex"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" S-acyltransferase activity"},{"category":"Function","description":" S-succinyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" dihydrolipoyllysine-residue succinyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"}],"pfams":[{"name":"Biotin_lipoyl","identifier":"PF00364"},{"name":"2-oxoacid_dh","identifier":"PF00198"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Lysine degradation","kegg_map_id":"00310"}],"gene_sequence":"ATGCTTTCCAGAGCGACGCGTACTGCAGCTGCCAAATCCTTAGTAAAATCTAAAGTGGCTAGAAATGTTATGGCTGCTTCTTTCGTCAAGAGACATGCTTCTACAAGTTTGTTCAAACAAGCTAACAAGGTCGAATCCTTAGGTTCAATATATTTATCCGGCAAGAAAATTTCAGTTGCGGCGAATCCGTTCTCCATAACTAGCAATCGTTTTAAATCTACCTCTATTGAAGTTCCTCCGATGGCAGAGTCCCTGACTGAAGGCTCTTTAAAGGAATATACTAAAAACGTTGGTGATTTTATTAAGGAGGACGAGCTGTTGGCCACTATTGAGACCGATAAAATTGATATTGAGGTCAATTCGCCAGTATCAGGTACTGTTACGAAGCTAAATTTCAAACCAGAGGACACTGTCACTGTTGGTGAGGAGTTAGCTCAGGTCGAGCCTGGTGAAGCACCTGCTGAGGGTTCTGGAGAATCTAAGCCAGAGCCTACCGAACAAGCGGAGCCATCGCAAGGTGTCGCCGCAAGGGAAAACTCAAGTGAGGAAACGGCTTCAAAGAAAGAAGCTGCTCCAAAGAAAGAAGCCGCTCCAAAGAAAGAAGTTACAGAACCAAAAAAGGCTGATCAACCAAAGAAGACCGTCTCTAAGGCGCAGGAACCCCCAGTAGCCTCTAACTCTTTCACACCATTTCCACGTACAGAAACCAGGGTCAAAATGAACCGTATGAGATTGAGGATTGCCGAAAGATTAAAAGAGTCTCAAAACACTGCTGCTTCCTTAACCACATTCAACGAAGTTGACATGTCAGCTTTGATGGAAATGAGGAAACTGTATAAAGATGAGATTATTAAGAAGACCGGTACTAAATTCGGATTCATGGGTCTTTTCTCCAAAGCATGTACCTTGGCCGCCAAGGATATTCCAGCCGTCAATGGTGCCATTGAAGGTGACCAGATTGTTTATCGTGATTACACAGATATTTCTGTTGCTGTGGCCACTCCAAAGGGTTTGGTTACCCCCGTCGTTCGTAATGCAGAGTCATTGAGTGTTTTAGATATTGAGAACGAAATTGTTCGCTTGAGTCATAAAGCGCGTGATGGCAAATTAACCCTAGAAGATATGACGGGTGGTACTTTCACCATATCTAATGGTGGTGTTTTTGGTTCATTATACGGTACTCCTATCATCAATTCACCACAAACAGCCGTCCTAGGCTTGCATGGTGTCAAAGAGAGACCTGTCACTGTTAATGGACAAATTGTCTCAAGACCAATGATGTACTTGGCTTTGACTTATGATCATAGATTGCTAGATGGTAGAGAAGCTGTTACCTTCTTGAAGACTGTTAAAGAGTTGATTGAAGACCCTAGAAAAATGTTGTTATGGTGA","protein_sequence":"MLSRATRTAAAKSLVKSKVARNVMAASFVKRHASTSLFKQANKVESLGSIYLSGKKISVAANPFSITSNRFKSTSIEVPPMAESLTEGSLKEYTKNVGDFIKEDELLATIETDKIDIEVNSPVSGTVTKLNFKPEDTVTVGEELAQVEPGEAPAEGSGESKPEPTEQAEPSQGVAARENSSEETASKKEAAPKKEAAPKKEVTEPKKADQPKKTVSKAQEPPVASNSFTPFPRTETRVKMNRMRLRIAERLKESQNTAASLTTFNEVDMSALMEMRKLYKDEIIKKTGTKFGFMGLFSKACTLAAKDIPAVNGAIEGDQIVYRDYTDISVAVATPKGLVTPVVRNAESLSVLDIENEIVRLSHKARDGKLTLEDMTGGTFTISNGGVFGSLYGTPIINSPQTAVLGLHGVKERPVTVNGQIVSRPMMYLALTYDHRLLDGREAVTFLKTVKELIEDPRKMLLW"},{"created_at":"2011-05-24T21:46:35.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Sphingosine N-acyltransferase LAG1","uniprot_id":"P38703","uniprot_name":"LAG1_YEAST","enzyme":true,"transporter":false,"gene_name":"LAG1","num_residues":411,"molecular_weight":"48454.10156","theoretical_pi":"9.17","general_function":"Involved in protein binding","specific_function":"Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAC1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. Involved in the aging process. Deletion of LAG1 results in a pronounced increase (approximately 50%) in mean and in maximum life span","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2395,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + sphingosine = CoA + N-acylsphingosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14344,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006855","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"82-102;135-155;177-197;212-232;252-272;297-317;356-376","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"AY558514","genbank_protein_id":"45270918","gene_card_id":"LAG1","chromosome_location":"chromosome 8","locus":"YHL003C","synonyms":["Longevity assurance factor 1","Longevity assurance gene 1 protein","Longevity assurance protein 1"],"enzyme_classes":["2.3.1.24"],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TRAM1","identifier":"PF08390"},{"name":"TRAM_LAG1_CLN8","identifier":"PF03798"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGACATCAGCTACGGACAAATCTATCGATAGGTTAGTTGTTAATGCAAAAACAAGAAGACGAAACTCTTCCGTGGGTAAAATTGATTTAGGTGATACAGTTCCTGGCTTTGCAGCCATGCCTGAAAGTGCTGCCTCTAAAAATGAGGCCAAAAAAAGGATGAAAGCCTTGACTGGTGACTCTAAAAAGGATAGTGACCTACTGTGGAAGGTTTGGTTTTCATATAGAGAAATGAATTACCGTCATAGTTGGTTGACACCATTCTTCATACTTGTATGCGTGTATAGCGCGTACTTTTTATCTGGGAATAGAACAGAATCAAACCCGCTGCACATGTTCGTAGCCATATCATATCAAGTTGATGGCACAGACTCATATGCAAAAGGTATCAAAGATTTGAGTTTTGTGTTTTTCTACATGATTTTCTTCACATTTTTACGTGAGTTTTTGATGGATGTTGTAATTCGACCATTCACGGTATACCTAAATGTTACTTCCGAGCATCGTCAAAAGCGTATGCTAGAACAAATGTATGCCATATTTTATTGCGGAGTTTCAGGGCCCTTTGGTCTTTATATTATGTACCATAGTGATTTGTGGTTGTTCAAGACAAAACCAATGTACAGAACATATCCTGTTATAACCAATCCGTTCTTGTTTAAGATATTTTACTTGGGTCAAGCGGCATTTTGGGCGCAACAGGCTTGTGTTCTTGTTCTACAATTAGAAAAGCCAAGAAAGGATTACAAGGAATTGGTTTTTCATCACATTGTGACATTATTATTAATTTGGTCATCATATGTTTTCCATTTTACCAAAATGGGATTGGCTATCTATATTACTATGGATGTGTCAGATTTTTTCCTTTCTTTGTCTAAGACATTAAACTATCTGAATTCTGTATTTACTCCCTTTGTGTTCGGCTTGTTCGTGTTCTTTTGGATCTATCTGCGCCATGTCGTGAATATCAGAATATTATGGTCAGTCTTAACAGAATTCCGTCATGAAGGTAATTATGTGTTGAATTTTGCCACACAACAATACAAATGTTGGATTTCGTTGCCAATTGTATTTGTACTAATTGCTGCGTTACAATTAGTTAACCTGTATTGGCTGTTTTTAATTCTTAGAATCTTGTACAGATTGATATGGCAAGGTATCCAAAAGGACGAAAGAAGTGACAGTGATTCTGATGAGAGCGCTGAAAATGAAGAATCTAAGGAAAAGTGTGAATAA","protein_sequence":"MTSATDKSIDRLVVNAKTRRRNSSVGKIDLGDTVPGFAAMPESAASKNEAKKRMKALTGDSKKDSDLLWKVWFSYREMNYRHSWLTPFFILVCVYSAYFLSGNRTESNPLHMFVAISYQVDGTDSYAKGIKDLSFVFFYMIFFTFLREFLMDVVIRPFTVYLNVTSEHRQKRMLEQMYAIFYCGVSGPFGLYIMYHSDLWLFKTKPMYRTYPVITNPFLFKIFYLGQAAFWAQQACVLVLQLEKPRKDYKELVFHHIVTLLLIWSSYVFHFTKMGLAIYITMDVSDFFLSLSKTLNYLNSVFTPFVFGLFVFFWIYLRHVVNIRILWSVLTEFRHEGNYVLNFATQQYKCWISLPIVFVLIAALQLVNLYWLFLILRILYRLIWQGIQKDERSDSDSDESAENEESKEKCE"},{"created_at":"2011-05-26T16:11:34.000Z","updated_at":"2011-07-22T17:54:25.000Z","name":"Sphingosine N-acyltransferase LAC1","uniprot_id":"P28496","uniprot_name":"LAC1_YEAST","enzyme":true,"transporter":false,"gene_name":"LAC1","num_residues":418,"molecular_weight":"48991.60156","theoretical_pi":"9.81","general_function":"Involved in identical protein binding","specific_function":"Component of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAG1. Facilitates ER-to-Golgi transport of GPI-anchored proteins","reactions":[{"id":1374,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1375,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1376,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1377,"direction":"\u003e","locations":"endoplasmic reticulum","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2395,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Multi-pass membrane protein","altext":"Acyl-CoA + sphingosine = CoA + N-acylsphingosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14344,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006855","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"82-102;135-155;173-193;222-242;260-280;297-317;356-376","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Z28008","genbank_protein_id":"485983","gene_card_id":"LAC1","chromosome_location":"chromosome 11","locus":"YKL008C","synonyms":[],"enzyme_classes":["2.3.1.24"],"go_classes":[{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TRAM1","identifier":"PF08390"},{"name":"TRAM_LAG1_CLN8","identifier":"PF03798"}],"pathways":[{"name":"Sphingolipid metabolism","kegg_map_id":"00600"}],"gene_sequence":"ATGTCGACAATAAAGCCAAGCCCTTCAAACAACAATTTGAAAGTGAGGTCAAGACCAAGACGCAAGTCTTCCATAGGTAAGATCGACCTCGGGGACACTGTACCTAGTTTAGGTACTATGTTCGAGACAAAAGAATCTAAAACGGCTGCTAAAAGGCGTATGCAGAGATTATCTGAAGCCACCAAAAATGATAGCGACCTGGTCAAGAAAATCTGGTTTTCATTCCGAGAGATAAGTTACCGTCATGCCTGGATAGCTCCCTTGATGATTTTAATCGCGGTATATAGTGCCTATTTCACTTCTGGTAACACTACAAAGACAAATGTGTTACATAGATTTGTCGCTGTGTCATACCAAATAGGTGATACCAACGCATATGGTAAAGGTATTAACGATTTGTGCTTTGTATTTTACTATATGATTTTTTTCACATTCTTACGTGAATTCCTAATGGATGTTGTCATTAGACCGTTCGCTATTAGGTTACACGTCACTTCTAAGCACAGAATAAAAAGAATCATGGAACAAATGTACGCTATTTTCTACACCGGTGTTTCCGGTCCTTTCGGGATATATTGTATGTACCATTCGGATTTATGGTTTTTCAACACAAAGGCAATGTACAGAACATATCCAGATTTCACTAATCCCTTCTTATTCAAGGTATTCTATTTGGGTCAAGCTGCATTTTGGGCTCAACAAGCCTGCATTCTTGTATTGCAACTAGAAAAGCCAAGAAAAGATCATAACGAGTTGACTTTCCATCATATTGTTACTTTACTATTGATTTGGTCTTCCTACGTATTTCATTTCACTAAAATGGGACTGCCAATCTATATCACAATGGATGTTTCTGATTTTCTTTTGTCATTCTCCAAAACTCTAAATTATTTGGACTCTGGATTGGCTTTTTTTTCTTTTGCTATCTTTGTTGTTGCGTGGATTTATTTGCGTCATTACATAAATTTAAAGATCCTATGGTCCGTTTTAACGCAATTTCGCACGGAAGGTAACTATGTCTTGAATTTTGCCACTCAGCAATATAAATGTTGGATTTCCTTACCAATTGTCTTTGTATTGATAGGCGCTTTGCAATTAGTGAATCTTTATTGGCTGTTCCTTATTTTTAGAGTTCTTTACAGGATTCTATGGAGAGGTATTCTCAAGGATGACAGAAGTGATAGTGAATCAGACGAAGAAAGTGATGAAAGTTCCACTACTCCAACTGACAGTACTCCAACGAAAAAGGATATTTGA","protein_sequence":"MSTIKPSPSNNNLKVRSRPRRKSSIGKIDLGDTVPSLGTMFETKESKTAAKRRMQRLSEATKNDSDLVKKIWFSFREISYRHAWIAPLMILIAVYSAYFTSGNTTKTNVLHRFVAVSYQIGDTNAYGKGINDLCFVFYYMIFFTFLREFLMDVVIRPFAIRLHVTSKHRIKRIMEQMYAIFYTGVSGPFGIYCMYHSDLWFFNTKAMYRTYPDFTNPFLFKVFYLGQAAFWAQQACILVLQLEKPRKDHNELTFHHIVTLLLIWSSYVFHFTKMGLPIYITMDVSDFLLSFSKTLNYLDSGLAFFSFAIFVVAWIYLRHYINLKILWSVLTQFRTEGNYVLNFATQQYKCWISLPIVFVLIGALQLVNLYWLFLIFRVLYRILWRGILKDDRSDSESDEESDESSTTPTDSTPTKKDI"},{"created_at":"2011-05-26T16:17:09.000Z","updated_at":"2011-05-27T15:00:59.000Z","name":"Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial","uniprot_id":"P53312","uniprot_name":"SUCB_YEAST","enzyme":true,"transporter":false,"gene_name":"LSC2","num_residues":427,"molecular_weight":"46900.30078","theoretical_pi":"7.56","general_function":"Involved in catalytic activity","specific_function":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA","reactions":[{"id":2376,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":3700,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003283","source":"Smpdb"},{"id":3701,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006825","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"Z73029","genbank_protein_id":"1323442","gene_card_id":"LSC2","chromosome_location":"chromosome 7","locus":"YGR244C","synonyms":["Succinyl-CoA synthetase beta chain","SCS-beta"],"enzyme_classes":["6.2.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Ligase_CoA","identifier":"PF00549"},{"name":"ATP-grasp_2","identifier":"PF08442"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTACTCAAGAAAATCCTTATCCCTAATTTCAAAGTGTGGGCAATTAAGCAGGCTAAACGCGCAAGCTGCTTTACAAGCAAGGAGACACTTGTCAATTCATGAATACAGGTCAGCTCAGTTATTGAGGGAATACGGTATTGGTACTCCAGAAGGATTTCCAGCGTTCACTCCCGAAGAGGCTTTCGAAGCAGCCAAGAAATTAAACACTAACAAACTGGTCATCAAGGCGCAGGCATTGACCGGAGGTAGAGGTAAAGGTCACTTCGACACCGGTTACAAAAGCGGTGTTCACATGATCGAAAGTCCTCAGCAGGCAGAGGATGTTGCAAAAGAAATGCTCAATCATAACCTGATTACTAAACAGACGGGAATAGCGGGGAAGCCAGTATCTGCTGTATATATAGTGAAAAGAGTAGATACAAAGCATGAAGCTTATTTATCTATTCTAATGGACAGACAAACCAAGAAACCGATGATCATTGCGTCCAGTCAAGGTGGTATGAATATTGAAGAGGTGGCTGAGAGAACCCCAGATGCTATAAAGAAATTTTCAATTGAAACTTCAAAGGGATTGAGCCCACAAATGGCCAAGGATGTTGCCAAGAGTCTCGGTTTCAGTCCCGATGCACAAGACGAGGCAGCAAAAGCTGTTTCCAATTTGTATAAAATATTCATGGAAAGGGATGCTACACAAGTGGAGATTAACCCTTTGAGTGAAATTGAACATGATCCAACCCACAAAATCATGTGTACAGACGCCAAATTTGGGTTTGATGATAACGCATCATTCAGACAGGAAAAGATATATTCCTGGAGGGACTTATCACAAGAAGATCCTGATGAAGTTAAGGCAAAGAAGTATGATTTGAATTTTGTTAAGTTGAAGGGTAACATTGGATGTTTAGTCAATGGTGCTGGTTTGGCTATGGCTACTATGGATGTCATCAAATTAAATGGAGGCGATCCTGCGAACTTTTTGGATTGTGGTGGTGGTGCCACCCCTGAGACCATCAAACAAGGTTTCGAATTGATCTTATCCAATAAGAACGTAGATGCAATTTTCGTCAATATTTTCGGCGGTATCGTAAGATGTGACTATGTTGCCCTGGGGCTGGTAGAAGCCGCCAGAGAACTAGAAGTTAGGGTCCCCATTGTGGCACGTTTGCAAGGTACCAAAGTAGAAGAAGGCCGCGACATTATCAATAAGTCAGGCGTGAAGATTTATTCGTTTGATGAATTAGATCCTGCTGCTAAAAAGGTCGTTGAATTGACCCAAAATTAA","protein_sequence":"MYSRKSLSLISKCGQLSRLNAQAALQARRHLSIHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGHFDTGYKSGVHMIESPQQAEDVAKEMLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSKGLSPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSEIEHDPTHKIMCTDAKFGFDDNASFRQEKIYSWRDLSQEDPDEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVIKLNGGDPANFLDCGGGATPETIKQGFELILSNKNVDAIFVNIFGGIVRCDYVALGLVEAARELEVRVPIVARLQGTKVEEGRDIINKSGVKIYSFDELDPAAKKVVELTQN"},{"created_at":"2011-05-26T16:18:45.000Z","updated_at":"2011-05-26T16:18:45.000Z","name":"Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial","uniprot_id":"P12695","uniprot_name":"ODP2_YEAST","enzyme":true,"transporter":false,"gene_name":"PDA2","num_residues":482,"molecular_weight":"51817.5","theoretical_pi":"8.02","general_function":"Involved in acyltransferase activity","specific_function":"The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)","reactions":[{"id":2414,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.","export":false,"pw_reaction_id":null,"source":null},{"id":3699,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003282","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY693185","genbank_protein_id":"51013821","gene_card_id":"PDA2","chromosome_location":null,"locus":"YNL071W","synonyms":["Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex","Pyruvate dehydrogenase complex component E2","PDC-E2","PDCE2"],"enzyme_classes":["2.3.1.12"],"go_classes":[{"category":"Component","description":" pyruvate dehydrogenase complex"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" dihydrolipoyllysine-residue acetyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" protein binding"},{"category":"Function","description":" acetyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" S-acetyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" pyruvate metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" monocarboxylic acid metabolic process"}],"pfams":[{"name":"Biotin_lipoyl","identifier":"PF00364"},{"name":"2-oxoacid_dh","identifier":"PF00198"},{"name":"E3_binding","identifier":"PF02817"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTCTGCCTTTGTCAGGGTGGTTCCAAGAATATCCAGAAGTTCAGTACTCACCAGATCATTGAGACTGCAATTGAGATGCTACGCATCGTACCCAGAGCACACCATTATTGGTATGCCGGCACTGTCTCCTACGATGACGCAAGGTAATCTTGCTGCTTGGACTAAGAAGGAAGGTGACCAATTGTCTCCCGGTGAAGTTATTGCCGAAATAGAAACAGACAAGGCTCAAATGGACTTTGAGTTCCAAGAAGATGGTTACTTAGCCAAGATTCTAGTTCCTGAAGGTACAAAGGACATTCCTGTCAACAAGCCTATTGCCGTCTATGTGGAGGACAAAGCTGATGTGCCAGCTTTTAAGGACTTTAAGCTGGAGGATTCAGGTTCTGATTCAAAGACCAGTACGAAGGCTCAGCCTGCCGAACCACAGGCAGAAAAGAAACAAGAAGCGCCAGCTGAAGAGACCAAGACTTCTGCACCTGAAGCTAAGAAATCTGACGTTGCTGCTCCTCAAGGTAGGATTTTTGCCTCTCCACTTGCCAAGACTATCGCCTTGGAAAAGGGTATTTCTTTGAAGGATGTTCACGGCACTGGACCCCGCGGTAGAATTACCAAGGCTGACATTGAGTCATATCTAGAAAAGTCGTCTAAGCAGTCTTCTCAAACCAGTGGTGCTGCCGCCGCCACTCCTGCCGCCGCTACCTCAAGCACTACTGCTGGCTCTGCTCCATCGCCTTCTTCTACAGCATCATATGAGGATGTTCCAATTTCAACCATGAGAAGCATCATTGGAGAACGTTTATTGCAATCTACTCAAGGCATTCCATCATACATCGTTTCCTCCAAGATATCCATCTCCAAACTTTTGAAATTGAGACAGTCCTTGAACGCTACAGCAAACGACAAGTACAAACTGTCCATTAATGACCTATTAGTAAAAGCCATCACTGTTGCGGCTAAGAGGGTGCCAGATGCCAATGCCTACTGGTTACCTAATGAGAACGTTATCCGTAAATTCAAGAATGTCGATGTCTCAGTCGCTGTTGCCACACCAACAGGATTATTGACACCAATTGTCAAGAATTGTGAGGCCAAGGGCTTGTCGCAAATCTCTAACGAAATCAAGGAACTAGTCAAGCGTGCCAGAATAAACAAATTGGCACCAGAGGAATTCCAAGGTGGGACCATTTGCATATCCAATATGGGCATGAATAATGCTGTTAACATGTTTACTTCGATTATCAACCCACCACAGTCTACAATCTTGGCCATCGCTACTGTTGAAAGGGTCGCTGTGGAAGACGCCGCTGCTGAGAACGGATTCTCCTTTGATAACCAGGTTACCATAACAGGGACCTTTGATCATAGAACCATTGATGGCGCCAAAGGTGCAGAATTCATGAAGGAATTGAAAACTGTTATTGAAAATCCTTTGGAAATGCTATTGTGA","protein_sequence":"MSAFVRVVPRISRSSVLTRSLRLQLRCYASYPEHTIIGMPALSPTMTQGNLAAWTKKEGDQLSPGEVIAEIETDKAQMDFEFQEDGYLAKILVPEGTKDIPVNKPIAVYVEDKADVPAFKDFKLEDSGSDSKTSTKAQPAEPQAEKKQEAPAEETKTSAPEAKKSDVAAPQGRIFASPLAKTIALEKGISLKDVHGTGPRGRITKADIESYLEKSSKQSSQTSGAAAATPAAATSSTTAGSAPSPSSTASYEDVPISTMRSIIGERLLQSTQGIPSYIVSSKISISKLLKLRQSLNATANDKYKLSINDLLVKAITVAAKRVPDANAYWLPNENVIRKFKNVDVSVAVATPTGLLTPIVKNCEAKGLSQISNEIKELVKRARINKLAPEEFQGGTICISNMGMNNAVNMFTSIINPPQSTILAIATVERVAVEDAAAENGFSFDNQVTITGTFDHRTIDGAKGAEFMKELKTVIENPLEMLL"},{"created_at":"2011-05-26T16:47:52.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Glutathione reductase","uniprot_id":"P41921","uniprot_name":"GSHR_YEAST","enzyme":true,"transporter":false,"gene_name":"GLR1","num_residues":483,"molecular_weight":"53440.60156","theoretical_pi":"7.96","general_function":"Involved in oxidoreductase activity","specific_function":"Maintains high levels of reduced glutathione in the cytosol","reactions":[{"id":2445,"direction":"\u003e","locations":"Cytoplasm","altext":"2 glutathione + NADP(+) = glutathione disulfide + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":3693,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003279","source":"Smpdb"},{"id":3694,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006559","source":"Smpdb"},{"id":3695,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006560","source":"Smpdb"},{"id":3696,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006561","source":"Smpdb"},{"id":3699,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003282","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U43281","genbank_protein_id":"1151235","gene_card_id":"GLR1","chromosome_location":"chromosome 16","locus":"YPL091W","synonyms":["GR","GRase"],"enzyme_classes":["1.8.1.7"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" NADP or NADPH binding"},{"category":"Function","description":" binding"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" disulfide oxidoreductase activity"},{"category":"Function","description":" peptide disulfide oxidoreductase activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" glutathione disulfide oxidoreductase activity"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" glutathione-disulfide reductase activity"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" cell redox homeostasis"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" peptide metabolic process"},{"category":"Process","description":" glutathione metabolic process"},{"category":"Process","description":" cellular process"}],"pfams":[{"name":"Pyr_redox","identifier":"PF00070"},{"name":"Pyr_redox_2","identifier":"PF07992"},{"name":"Pyr_redox_dim","identifier":"PF02852"}],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGCTTTCTGCAACCAAACAAACATTTAGAAGTCTACAGATAAGAACTATGTCCACGAACACCAAGCATTACGATTACCTCGTCATCGGGGGTGGCTCAGGGGGTGTTGCTTCCGCAAGAAGAGCTGCATCTTATGGTGCGAAGACATTACTAGTTGAAGCTAAGGCTCTTGGTGGTACCTGTGTTAACGTGGGTTGTGTTCCGAAGAAAGTCATGTGGTATGCTTCTGACCTCGCTACTAGAGTATCCCATGCAAATGAATATGGATTATATCAGAATCTTCCATTAGATAAAGAGCATTTGACTTTTAATTGGCCAGAATTTAAGCAGAAAAGGGATGCTTATGTCCATAGGTTGAACGGTATATACCAGAAGAATTTAGAAAAAGAAAAAGTGGATGTTGTATTTGGATGGGCTAGATTCAATAAGGACGGTAATGTTGAAGTTCAGAAAAGGGATAATACTACTGAAGTTTACTCCGCTAACCATATTTTAGTTGCGACCGGTGGAAAGGCTATTTTCCCCGAAAACATTCCAGGTTTCGAATTAGGTACTGATTCTGATGGGTTCTTTAGATTGGAAGAACAACCTAAGAAAGTTGTTGTTGTTGGCGCTGGTTATATTGGTATTGAGCTAGCAGGTGTGTTCCATGGGCTGGGATCCGAAACGCACTTGGTAATTAGAGGTGAAACTGTCTTGAGAAAATTTGATGAATGCATCCAGAACACTATTACTGACCATTACGTAAAGGAAGGCATCAACGTTCATAAACTATCCAAAATTGTTAAGGTGGAGAAAAATGTAGAAACTGACAAACTGAAAATACATATGAATGACTCAAAGTCCATCGATGACGTTGACGAATTAATTTGGACAATTGGACGTAAATCCCATCTAGGTATGGGTTCAGAAAATGTAGGTATAAAGCTGAACTCTCATGACCAAATAATTGCTGATGAATATCAGAACACCAATGTTCCAAACATTTATTCTCTAGGTGACGTTGTTGGAAAAGTTGAATTGACACCTGTCGCTATTGCAGCGGGCAGAAAGCTGTCTAATAGACTGTTTGGTCCAGAGAAATTCCGTAATGACAAACTAGATTACGAGAACGTCCCCAGCGTAATTTTCTCACATCCTGAAGCCGGTTCCATTGGTATTTCTGAGAAGGAAGCCATTGAAAAGTACGGTAAGGAGAATATAAAGGTCTACAATTCCAAATTTACCGCCATGTACTATGCTATGTTGAGTGAGAAATCACCCACAAGATATAAAATTGTTTGTGCGGGACCAAATGAAAAGGTTGTCGGTCTGCACATTGTTGGTGATTCCTCTGCAGAAATCTTGCAAGGGTTCGGTGTTGCTATAAAGATGGGTGCCACTAAGGCTGATTTCGATAATTGTGTTGCTATTCATCCGACTAGCGCAGAAGAATTGGTTACTATGAGATGA","protein_sequence":"MLSATKQTFRSLQIRTMSTNTKHYDYLVIGGGSGGVASARRAASYGAKTLLVEAKALGGTCVNVGCVPKKVMWYASDLATRVSHANEYGLYQNLPLDKEHLTFNWPEFKQKRDAYVHRLNGIYQKNLEKEKVDVVFGWARFNKDGNVEVQKRDNTTEVYSANHILVATGGKAIFPENIPGFELGTDSDGFFRLEEQPKKVVVVGAGYIGIELAGVFHGLGSETHLVIRGETVLRKFDECIQNTITDHYVKEGINVHKLSKIVKVEKNVETDKLKIHMNDSKSIDDVDELIWTIGRKSHLGMGSENVGIKLNSHDQIIADEYQNTNVPNIYSLGDVVGKVELTPVAIAAGRKLSNRLFGPEKFRNDKLDYENVPSVIFSHPEAGSIGISEKEAIEKYGKENIKVYNSKFTAMYYAMLSEKSPTRYKIVCAGPNEKVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAEELVTMR"},{"created_at":"2011-05-27T02:46:14.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"2-oxoglutarate dehydrogenase, mitochondrial","uniprot_id":"P20967","uniprot_name":"ODO1_YEAST","enzyme":true,"transporter":false,"gene_name":"KGD1","num_residues":1014,"molecular_weight":"114416.0","theoretical_pi":"7.23","general_function":"Involved in oxoglutarate dehydrogenase (succinyl-transferring) activity","specific_function":"The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)","reactions":[{"id":2693,"direction":"\u003e","locations":"Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid","altext":"2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3699,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003282","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid","genbank_gene_id":"M26390","genbank_protein_id":"171785","gene_card_id":"KGD1","chromosome_location":"chromosome 9","locus":"YIL125W","synonyms":["2-oxoglutarate dehydrogenase complex component E1","OGDC-E1","Alpha-ketoglutarate dehydrogenase"],"enzyme_classes":["1.2.4.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" thiamin pyrophosphate binding"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxoglutarate dehydrogenase (succinyl-transferring) activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"}],"pfams":[{"name":"Transket_pyr","identifier":"PF02779"},{"name":"E1_dh","identifier":"PF00676"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Lysine degradation","kegg_map_id":"00310"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGCTAAGGTTCGTGTCTTCGCAAACCTGCCGGTATAGTTCAAGAGGACTATTAAAAACATCTTTACTTAAAAATGCATCTACTGTCAAAATTGTCGGAAGAGGGTTAGCCACCACTGGTACAGATAATTTTCTATCGACATCAAATGCCACCTATATCGATGAAATGTACCAAGCTTGGCAAAAAGACCCATCTTCAGTCCATGTTTCATGGGACGCATATTTCAAGAATATGTCTAACCCAAAGATTCCAGCTACAAAGGCTTTTCAGGCTCCTCCCAGTATCAGTAACTTTCCCCAGGGTACCGAAGCAGCTCCCTTAGGGACCGCAATGACTGGTTCAGTAGATGAGAACGTCTCCATTCATCTAAAAGTGCAATTGCTATGTAGAGCTTACCAAGTTAGAGGTCATTTAAAAGCCCATATAGATCCTTTAGGGATCTCATTTGGTAGTAATAAAAATAACCCTGTTCCTCCGGAATTGACTCTAGACTACTACGGCTTTAGCAAACACGATCTTGATAAAGAAATCAACCTAGGACCTGGTATCCTGCCAAGGTTTGCAAGGGACGGGAAATCTAAAATGTCTCTGAAAGAGATTGTGGATCATCTAGAAAAGTTATATTGTTCCTCTTATGGGGTACAATACACACATATTCCATCTAAGCAAAAGTGTGATTGGTTAAGAGAGAGAATTGAGATTCCTGAACCTTACCAATATACAGTGGACCAAAAGAGACAAATCTTAGATAGATTAACATGGGCCACTTCTTTTGAGTCATTCTTATCTACAAAATTTCCAAATGATAAGAGGTTCGGTTTAGAAGGTTTGGAAAGTGTTGTTCCAGGTATTAAAACTTTGGTTGATCGTTCTGTTGAATTGGGTGTAGAAGATATTGTTTTGGGTATGGCTCACCGTGGTAGATTGAACGTTTTATCCAATGTGGTCCGTAAACCAAATGAATCTATTTTTCTGAATTTAAAGGGTTCGAGCGCTCGCGATGATATTGAAGGATCGGGTGATGTCAAGTACCATTTGGGTATGAACTACCAAAGACCAACTACGTCTGGTAAGTACGTCAATTTATCGCTGGTGGCAAATCCTTCTCATTTAGAATCCCAAGATCCAGTTGTTCTTGGTAGAACTAGAGCTTTATTGCATGCCAAGAACGATTTGAAGGAAAAAACAAAGGCCTTAGGTGTGTTATTACATGGTGATGCTGCTTTTGCTGGGCAGGGTGTTGTTTATGAAACCATGGGTTTCTTGACCCTACCAGAATACTCTACTGGTGGTACTATTCATGTTATTACAAACAACCAGATCGGATTCACTACGGATCCAAGATTTGCAAGGTCCACACCATATCCTTCCGATTTGGCTAAGGCCATTGATGCCCCAATTTTCCATGTTAACGCTAATGACGTGGAAGCTGTGACCTTTATTTTCAATTTAGCCGCAGAATGGAGACATAAGTTCCACACAGATGCCATAATTGATGTCGTTGGTTGGAGAAAACATGGACATAATGAAACCGATCGACCATCGTTTACTCAACCATTAATGTACAAAAAAATTGCAAAACAAAAATCTGTCATTGACGTCTATACGGAAAAATTGATAAGTGAAGGCACATTTTCTAAAAAAGATATTGATGAGCACAAGAAATGGGTATGGAACTTATTTGAAGATGCTTTCGAAAAGACAAAGGATTACGTCCCATCTCAAAGAGAATGGTTAACTGCTGCCTGGGAAGGATTCAAATCCCCAAAGGAATTGGCCACTGAGATATTACCACATGAACCAACTAATGTTCCAGAGAGTACTTTGAAAGAACTAGGTAAGGTACTCTCTTCGTGGCCAGAAGGTTTTGAAGTGCACAAAAATCTAAAGAGAATTTTGAAAAATAGAGGAAAATCTATTGAGACAGGTGAAGGCATCGATTGGGCCACCGGTGAAGCATTAGCGTTCGGTACATTGGTTTTGGATGGTCAGAACGTTAGGGTTTCCGGTGAAGATGTAGAAAGAGGTACATTTTCTCAACGTCATGCAGTCTTGCATGACCAACAATCTGAAGCCATTTACACACCGCTAAGCACTCTGAATAATGAAAAGGCAGACTTCACCATTGCAAATTCCTCGTTATCTGAGTACGGTGTAATGGGTTTCGAATATGGTTATTCGCTAACCTCCCCAGATTATCTAGTCATGTGGGAGGCTCAATTCGGTGACTTTGCAAATACAGCACAGGTTATTATTGACCAATTTATTGCCGGTGGTGAACAAAAATGGAAGCAACGCTCTGGTTTAGTTTTGTCTTTACCCCATGGTTATGATGGCCAGGGGCCAGAACATTCGTCTGGTAGATTGGAAAGATTCTTGCAACTAGCCAATGAAGACCCAAGATATTTCCCATCTGAAGAAAAGCTACAGAGACAACATCAGGATTGTAATTTCCAGGTTGTTTATCCAACTACGCCTGCTAATTTATTCCACATTCTAAGGAGACAGCAACATCGTCAATTCCGTAAACCATTGGCGTTATTCTTTTCTAAACAGCTGCTGCGTCACCCATTGGCCAGATCATCTCTTTCCGAATTCACTGAAGGCGGATTCCAATGGATTATCGAAGATATTGAACATGGAAAAAGTATTGGTACGAAAGAGGAAACCAAGAGATTAGTTTTGCTGAGTGGCCAAGTGTACACTGCCCTACATAAAAGACGTGAAAGTTTGGGTGATAAGACCACTGCTTTCTTAAAGATTGAACAGCTGCACCCATTCCCATTTGCTCAGCTACGTGATTCATTAAATTCTTATCCAAACTTGGAAGAAATTGTTTGGTGCCAGGAAGAGCCATTGAACATGGGTTCGTGGGCATACACAGAACCACGCTTACACACAACATTAAAAGAAACGGATAAATATAAGGATTTCAAGGTCAGATACTGTGGTAGAAACCCAAGTGGTGCTGTTGCTGCCGGTAGCAAATCACTACATTTGGCCGAAGAAGATGCCTTTTTGAAAGATGTTTTCCAACAATCCTAA","protein_sequence":"MLRFVSSQTCRYSSRGLLKTSLLKNASTVKIVGRGLATTGTDNFLSTSNATYIDEMYQAWQKDPSSVHVSWDAYFKNMSNPKIPATKAFQAPPSISNFPQGTEAAPLGTAMTGSVDENVSIHLKVQLLCRAYQVRGHLKAHIDPLGISFGSNKNNPVPPELTLDYYGFSKHDLDKEINLGPGILPRFARDGKSKMSLKEIVDHLEKLYCSSYGVQYTHIPSKQKCDWLRERIEIPEPYQYTVDQKRQILDRLTWATSFESFLSTKFPNDKRFGLEGLESVVPGIKTLVDRSVELGVEDIVLGMAHRGRLNVLSNVVRKPNESIFSEFKGSSARDDIEGSGDVKYHLGMNYQRPTTSGKYVNLSLVANPSHLESQDPVVLGRTRALLHAKNDLKEKTKALGVLLHGDAAFAGQGVVYETMGFLTLPEYSTGGTIHVITNNQIGFTTDPRFARSTPYPSDLAKAIDAPIFHVNANDVEAVTFIFNLAAEWRHKFHTDAIIDVVGWRKHGHNETDQPSFTQPLMYKKIAKQKSVIDVYTEKLISEGTFSKKDIDEHKKWVWNLFEDAFEKAKDYVPSQREWLTAAWEGFKSPKELATEILPHEPTNVPESTLKELGKVLSSWPEGFEVHKNLKRILKNRGKSIETGEGIDWATGEALAFGTLVLDGQNVRVSGEDVERGTFSQRHAVLHDQQSEAIYTPLSTLNNEKADFTIANSSLSEYGVMGFEYGYSLTSPDYLVMWEAQFGDFANTAQVIIDQFIAGGEQKWKQRSGLVLSLPHGYDGQGPEHSSGRLERFLQLANEDPRYFPSEEKLQRQHQDCNFQVVYPTTPANLFHILRRQQHRQFRKPLALFFSKQLLRHPLARSSLSEFTEGGFQWIIEDIEHGKSIGTKEETKRLVLLSGQVYTALHKRRESLGDKTTAFLKIEQLHPFPFAQLRDSLNSYPNLEEIVWCQEEPLNMGSWAYTEPRLHTTLKETDKYKDFKVRYCGRNPSGAVAAGSKSLHLAEEDAFLKDVFQQS"}]}