{"ymdb_id":"YMDB00381","created_at":"2011-05-29T18:11:20.000Z","updated_at":"2016-09-08T18:35:25.000Z","name":"Thiamine pyrophosphate","cas":"154-87-0","state":"Solid","melting_point":null,"description":"Thiamine pyrophosphate (ThDP) is one of the five known natural thiamine phosphate derivatives. Thiamine (vitamin B1) is the transport form of the vitamin, while the phosphorylated derivatives are the active forms. Thiamine pyrophosphate serves as a cofactor for several enzymes involved primarily in carbohydrate catabolism.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":"Zabrodskaya, S. V.; Oparin, D. A.; Ostrovskii, Yu. M. Selective synthesis of thiamine diphosphate. Zhurnal Obshchei Khimii (1989), 59(1), 226-7. ","chebi_id":"9532","hmdb_id":"HMDB01372","kegg_id":"C00068","pubchem_id":"1132","cs_id":"73580","foodb_id":null,"wikipedia_link":"Thiamine_pyrophosphate","biocyc_id":"2-(alpha-lactyl)-thpp","iupac":"3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium","traditional_iupac":"thiamin pyrophosphate","logp":"-5.79955409211528","pka":"3.2177664195972664","alogps_solubility":"1.52e-01 g/l","alogps_logp":"-1.21","alogps_logs":"-3.48","acceptor_count":"8","donor_count":"4","rotatable_bond_count":"8","polar_surface_area":"168.97","refractivity":"95.1455","polarizability":"36.9637991067903","formal_charge":"1","physiological_charge":"-1","pka_strongest_basic":"5.534004899065866","pka_strongest_acidic":"1.7783059358514746","bioavailability":"1","number_of_rings":"2","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["Thaimine pyrophosphate","thiamin diphosphate","thiamin pyrophosphate","thiamin-PPi","thiamine diphosphate","Thiamine pyrophosphate","Thiamine pyrophosphic acid","thiamine-PPi","thiamine-pyrophosphate","ThPP","TPP"],"pathways":[{"name":"Thiamine metabolism","kegg_map_id":"00730"},{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Valine, leucine and isoleucine degradation","kegg_map_id":"00280"},{"name":"Citric Acid Cycle","kegg_map_id":null},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":18028398,"citation":"Onozuka, M., Konno, H., Kawasaki, Y., Akaji, K., Nosaka, K. (2008). \"Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae.\" FEMS Yeast Res 8:266-275."}],"proteins":[{"created_at":"2011-05-26T16:47:52.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Glutathione reductase","uniprot_id":"P41921","uniprot_name":"GSHR_YEAST","enzyme":true,"transporter":false,"gene_name":"GLR1","num_residues":483,"molecular_weight":"53440.60156","theoretical_pi":"7.96","general_function":"Involved in oxidoreductase activity","specific_function":"Maintains high levels of reduced glutathione in the cytosol","reactions":[{"id":2445,"direction":"\u003e","locations":"Cytoplasm","altext":"2 glutathione + NADP(+) = glutathione disulfide + 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pyrophosphokinase","uniprot_id":"P35202","uniprot_name":"THI80_YEAST","enzyme":true,"transporter":false,"gene_name":"THI80","num_residues":319,"molecular_weight":"36615.69922","theoretical_pi":"6.26","general_function":"Involved in thiamine diphosphokinase activity","specific_function":"Essential protein, it is the only enzyme in yeast capable of synthesizing thiamine pyrophosphate (TPP)","reactions":[{"id":2001,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2002,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2546,"direction":"\u003e","locations":null,"altext":"ATP + thiamine = AMP + thiamine diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14443,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006957","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1IG0","cellular_location":null,"genbank_gene_id":"D14417","genbank_protein_id":"416427","gene_card_id":"THI80","chromosome_location":"chromosome 15","locus":"YOR143C","synonyms":["TPK","Thiamine kinase"],"enzyme_classes":["2.7.6.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" diphosphotransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" thiamin diphosphokinase activity"},{"category":"Process","description":" thiamin and derivative metabolic process"},{"category":"Process","description":" thiamin metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" thiamin diphosphate biosynthetic process"}],"pfams":[{"name":"TPK_catalytic","identifier":"PF04263"}],"pathways":[{"name":"Thiamine metabolism","kegg_map_id":"00730"},{"name":"Vitamin B1/Thiamine 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CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3693,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003279","source":"Smpdb"},{"id":3694,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006559","source":"Smpdb"},{"id":3695,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006560","source":"Smpdb"},{"id":3696,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006561","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY692982","genbank_protein_id":"51013415","gene_card_id":"PDB1","chromosome_location":"chromosome 2","locus":"YBR221C","synonyms":["Pyruvate dehydrogenase complex component E1 beta","PDHE1-B"],"enzyme_classes":["1.2.4.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Transket_pyr","identifier":"PF02779"},{"name":"Transketolase_C","identifier":"PF02780"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTTTTCCAGACTGCCAACATCATTGGCCAGAAATGTTGCACGTCGTGCCCCAACTTCTTTTGTAAGACCCTCTGCAGCAGCAGCAGCATTGAGATTCTCATCAACAAAGACGATGACCGTCAGAGAGGCCTTGAATAGTGCCATGGCGGAAGAATTGGACCGTGATGATGATGTCTTCCTTATTGGTGAAGAAGTTGCACAATATAACGGGGCTTATAAGGTGTCAAAGGGTTTATTGGACAGGTTCGGTGAACGTCGTGTGGTTGACACACCTATTACCGAATACGGGTTCACAGGTTTGGCCGTTGGTGCCGCTTTGAAGGGTTTGAAGCCAATTGTAGAGTTTATGTCGTTCAATTTCTCTATGCAAGCTATCGATCATGTTGTCAATTCCGCTGCAAAGACTCACTACATGTCTGGTGGTACTCAAAAATGTCAAATGGTCTTCAGAGGTCCTAATGGTGCTGCAGTGGGTGTTGGTGCTCAACATTCACAGGACTTTTCTCCTTGGTACGGTTCCATTCCAGGGTTAAAGGTCCTTGTCCCTTATTCTGCTGAAGATGCTAGGGGTTTGTTAAAGGCCGCCATCAGAGATCCAAACCCTGTTGTATTTTTAGAGAACGAATTGTTGTACGGTGAATCTTTTGAAATCTCAGAAGAAGCTTTATCCCCTGAGTTCACCTTGCCATACAAGGCTAAGATCGAAAGAGAAGGTACCGATATTTCCATTGTTACGTACACAAGAAACGTTCAGTTTTCTTTGGAAGCCGCTGAAATTCTACAAAAGAAATATGGTGTCTCTGCAGAAGTTATCAACTTGCGTTCTATTAGACCTTTAGATACTGAAGCTATCATCAAAACTGTCAAGAAGACAAACCACTTGATTACTGTTGAATCCACTTTCCCATCATTTGGTGTTGGTGCTGAAATTGTCGCCCAAGTTATGGAGTCTGAAGCCTTTGATTACTTGGATGCTCCAATCCAAAGAGTTACTGGTGCCGATGTTCCAACACCTTACGCTAAAGAATTAGAAGATTTCGCTTTCCCTGATACTCCAACCATCGTTAAAGCTGTCAAAGAAGTCTTGTCAATTGAATAA","protein_sequence":"MFSRLPTSLARNVARRAPTSFVRPSAAAAALRFSSTKTMTVREALNSAMAEELDRDDDVFLIGEEVAQYNGAYKVSKGLLDRFGERRVVDTPITEYGFTGLAVGAALKGLKPIVEFMSFNFSMQAIDHVVNSAAKTHYMSGGTQKCQMVFRGPNGAAVGVGAQHSQDFSPWYGSIPGLKVLVPYSAEDARGLLKAAIRDPNPVVFLENELLYGESFEISEEALSPEFTLPYKAKIEREGTDISIVTYTRNVQFSLEAAEILQKKYGVSAEVINLRSIRPLDTEAIIKTVKKTNHLITVESTFPSFGVGAEIVAQVMESEAFDYLDAPIQRVTGADVPTPYAKELEDFAFPDTPTIVKAVKEVLSIE"},{"created_at":"2011-05-27T05:17:24.000Z","updated_at":"2011-05-27T15:01:23.000Z","name":"Constitutive acid phosphatase","uniprot_id":"P24031","uniprot_name":"PPA3_YEAST","enzyme":true,"transporter":false,"gene_name":"PHO3","num_residues":467,"molecular_weight":"52776.10156","theoretical_pi":"4.21","general_function":"Involved in acid phosphatase activity","specific_function":"A phosphate monoester + H(2)O = an alcohol + phosphate","reactions":[{"id":1997,"direction":null,"locations":"extracellular","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1999,"direction":null,"locations":"extracellular","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2499,"direction":"\u003e","locations":"Cytoplasmic;Cytoplasm; Single-pass membrane protein (Potential).;Secreted;Vacuole membrane","altext":"A phosphate monoester + H(2)O = an alcohol + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14442,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006956","source":"Smpdb"}],"signal_regions":"1-17","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"X01080","genbank_protein_id":"758280","gene_card_id":"PHO3","chromosome_location":"chromosome 2","locus":"YBR092C","synonyms":[],"enzyme_classes":["3.1.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" acid phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Acid_phosphat_A","identifier":"PF00328"}],"pathways":[{"name":"Riboflavin metabolism","kegg_map_id":"00740"},{"name":"Vitamin B1/Thiamine metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTTAAATCTGTTGTTTATTCAATTTTAGCCGCTTCTTTGGCCAATGCAGGTACCATTCCCTTAGGCAAACTAGCCGATGTCGACAAGATTGGTACCCAAAAAGATATCTTCCCATTTTTGGGTGGTGCCGGACCATACTACTCTTTCCCTGGCGACTATGGTATTTCTCGTGATTTGCCTGAAGGTTGTGAAATGAAGCAACTGCAAATGGTTGGTAGACATGGTGAAAGATACCCTACTGTCAGTCTGGCTAAGACTATCAAGAGTACATGGTATAAGTTGAGCAATTACACTCGTCAATTCAACGGCTCATTGTCATTCTTGAACGATGATTACGAGTTTTTCATCCGTGATGACGATGATTTGGAAATGGAAACCACTTTTGCCAACTCGGACGATGTTTTGAACCCATACACTGGTGAAATGAACGCCAAGAGACATGCTCGTGACTTCTTGGCTCAATACGGTTACATGGTCGAAAACCAAACCAGTTTCGCCGTTTTTACCTCTAATTCTAAGAGATGTCATGACACTGCTCAATATTTCATTGATGGTTTAGGTGACCAATTCAACATCACCTTGCAGACTGTCAGTGAAGCTGAATCCGCTGGTGCCAACACTTTGAGTGCTTGTAACTCATGTCCTGCTTGGGACTACGATGCCAATGATGACATTGTAAATGAATACGACACAACCTACTTGGATGACATTGCCAAGAGATTGAACAAGGAAAACAAGGGTTTGAACTTGACCTCAACTGACGCTAGTACTTTATTCTCGTGGTGTGCATTTGAAGTGAACGCTAAAGGTTACAGTGATGTCTGTGATATTTTCACCAAGGATGAATTAGTCCATTACTCCTACTACCAAGACTTGCACACTTATTACCATGAGGGTCCAGGTTACGACATTATCAAGTCTGTCGGTTCCAACTTGTTCAATGCCTCAGTCAAATTATTAAAGCAAAGTGAGATTCAAGACCAAAAGGTTTGGTTGAGTTTTACCCACGATACCGATATCCTAAACTTTTTGACCACCGCTGGTATAATTGACGACAAAAACAACTTAACTGCCGAATACGTTCCATTCATGGGCAACACTTTCCACAGATCCTGGTACGTTCCTCAAGGTGCTCGTGTCTACACCGAAAAATTCCAATGTTCTAACGACACCTACGTCAGATACGTCATTAACGATGCTGTTGTTCCAATTGAAACCTGTTCCACTGGTCCAGGGTTCTCTTGTGAAATCAATGACTTCTACGACTATGCTGAAAAGAGAGTAGCCGGTACTGACTTCCTAAAGGTCTGTAACGTCAGCAGCGTCAGTAACTCTACTGAATTGACCTTCTACTGGGACTGGAACACTACTCATTACAACGCCAGTCTATTGAGACAATAG","protein_sequence":"MFKSVVYSVLAAALVNAGTIPLGELADVAKIGTQEDIFPFLGGAGPYFSFPGDYGISRDLPEGCEMKQLQMLARHGERYPTYSKGATIMKTWYKLSNYTRQFNGSLSFLNDDYEFFIRDDDDLEMETTFANSDNVLNPYTGEMDAKRHAREFLAQYGYMFENQTSFPIFAASSERVHDTAQYFIDGLGDQFNISLQTVSEAMSAGANTLSAGNACPGWDEDANDDILDKYDTTYLDDIAKRLNKENKGLNLTSKDANTLFAWCAYELNARGYSDVCDIFTEDELVRYSYGQDLVSFYQDGPGYDMIRSVGANLFNATLKLLKQSETQDLKVWLSFTHDTDILNYLTTAGIIDDKNNLTAEYVPFMGNTFHKSWYVPQGARVYTEKFQCSNDTYVRYVINDAVVPIETCSTGPGFSCEINDFYDYAEKRVAGTDFLKVCNVSSVSNVTELTFYWDWNTTHYNDTLLKQ"},{"created_at":"2011-06-03T16:22:38.000Z","updated_at":"2011-06-03T16:22:38.000Z","name":"Mitochondrial thiamine pyrophosphate carrier 1","uniprot_id":"P53257","uniprot_name":"TPC1_YEAST","enzyme":false,"transporter":true,"gene_name":"TPC1","num_residues":314,"molecular_weight":"35136.5","theoretical_pi":"10.43","general_function":"Involved in binding","specific_function":"Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria","reactions":[],"signal_regions":"None","transmembrane_regions":"14-30;84-100;116-136;170-186;217-233;285-302","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":"AY693109","genbank_protein_id":"51013669","gene_card_id":"TPC1","chromosome_location":null,"locus":"YGR096W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" organelle inner membrane"},{"category":"Component","description":" mitochondrial inner membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" binding"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[],"gene_sequence":"ATGTTCAAAGAGGAGGACTCGTTAAGAAAAGGGCAAAATGTGGCCGCGTGGAAAACTTTGTTGGCTGGCGCCGTATCCGGGCTGCTTGCCCGTAGCATAACTGCTCCCATGGATACCATTAAGATCAGATTGCAATTGACCCCTGCAAATGGGCTGAAGCCCTTCGGAAGTCAGGTCATGGAGGTGGCCAGAAGCACGATAAAGAACGAAGGCATCCGGTCCTTTTGGAAGGGTAACATACCCGGTTCTTTGCTGTACGTTACCTATGGCTCAGCGCAGTTTAGTTCATACTCCCTTTTTAATAGATATTTAACTCCATTTGGACTAGAGGCGCGCTTACATAGTCTTGTTGTCGGAGCCTTTGCTGGCATAACCAGTTCCATCGTTTCCTACCCGTTCGATGTTTTACGGACCCGACTAGTTGCCAACAACCAGATGCACTCAATGAGCATCACGAGAGAAGTGCGTGATATCTGGAAACTAGAAGGTCTCCCCGGATTTTTCAAGGGCTCCATCGCGTCAATGACAACCATAACTCTAACCGCATCTATAATGTTCGGAACATACGAAACAATCAGGATATACTGTGACGAAAACGAAAAAACGACCGCCGCGCATAAAAAATGGGAACTGGCTACTTTAAATCACAGCGCTGGTACCATTGGCGGCGTCATTGCTAAGATCATTACTTTCCCCCTCGAAACGATCCGTAGGCGAATGCAGTTCATGAATTCGAAGCATCTGGAAAAGTTCTCCCGTCATTCGTCTGTATACGGTTCTTATAAAGGGTACGGATTCGCAAGAATCGGTTTACAGATTTTGAAACAAGAAGGTGTGAGTTCGCTTTACAGAGGTATTCTGGTGGCCCTTTCCAAGACAATACCCACCACTTTTGTGAGTTTCTGGGGGTATGAAACTGCCATCCATTATTTGCGGATGTACTAA","protein_sequence":"MFKEEDSLRKGQNVAAWKTLLAGAVSGLLARSITAPMDTIKIRLQLTPANGLKPFGSQVMEVARSMIKNEGIRSFWKGNIPGSLLYVTYGSAQFSSYSLFNRYLTPFGLEARLHSLVVGAFAGITSSIVSYPFDVLRTRLVANNQMHSMSITREVRDIWKLEGLPGFFKGSIASMTTITLTASIMFGTYETIRIYCDENEKTTAAHKKWELATLNHSAGTIGGVIAKIITFPLETIRRRMQFMNSKHLEKFSRHSSVYGSYKGYGFARIGLQILKQEGVSSLYRGILVALSKTIPTTFVSFWGYETAIHYLRMY"},{"created_at":"2011-07-22T06:50:26.000Z","updated_at":"2011-07-22T06:50:26.000Z","name":"Pyruvate dehydrogenase complex protein X component, mitochondrial","uniprot_id":"P16451","uniprot_name":"ODPX_YEAST","enzyme":false,"transporter":false,"gene_name":"PDX1","num_residues":410,"molecular_weight":"45361.30078","theoretical_pi":"5.41","general_function":"Energy production and conversion","specific_function":"Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex","reactions":[{"id":3693,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003279","source":"Smpdb"},{"id":3694,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006559","source":"Smpdb"},{"id":3695,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006560","source":"Smpdb"},{"id":3696,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006561","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"M28222","genbank_protein_id":"172268","gene_card_id":"PDX1","chromosome_location":null,"locus":null,"synonyms":["Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex","E3-binding protein","Pyruvate dehydrogenase complex component E3BP"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"catalytic activity"},{"category":"Function","description":"transferase activity"},{"category":"Function","description":"transferase activity, transferring acyl groups"},{"category":"Function","description":"transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":"acyltransferase activity"},{"category":"Function","description":"protein binding"},{"category":"Function","description":"binding"},{"category":"Process","description":"metabolic process"}],"pfams":[{"name":"Biotin_lipoyl","identifier":"PF00364"}],"pathways":[{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGCTAAGTGCAATTTCCAAAGTCTCCACTTTAAAATCATGTACAAGATATTTAACCAAATGCAACTATCATGCATCAGCTAAATTACTTGCTGTAAAGACATTTTCAATGCCTGCAATGTCTCCTACTATGGAGAAAGGGGGGATTGTGTCTTGGAAATATAAAGTTGGCGAACCATTCAGCGCGGGCGATGTGATATTAGAAGTGGAAACAGATAAATCTCAAATTGATGTGGAAGCACTGGACGATGGTAAACTAGCTAAGATCCTGAAAGATGAAGGCTCTAAAGATGTTGATGTTGGTGAACCTATTGCTTATATTGCTGATGTTGATGATGATTTAGCTACTATAAAGTTACCCCAAGAGGCCAACACCGCAAATGCGAAATCTATTGAAATTAAGAAGCCATCCGCAGATAGTACTGAAGCAACACAACAACATTTAAAAAAAGCCACAGTTACACCAATAAAAACCGTTGACGGCAGCCAAGCCAATCTTGAACAGACGCTATTACCATCCGTGTCATTACTACTGGCTGAGAACAATATATCCAAACAAAAGGCTTTGAAGGAAATTGCGCCATCTGGTTCCAACGGTAGACTATTAAAGGGTGATGTGCTAGCATACCTAGGGAAAATACCACAAGATTCGGTTAACAAGGTAACAGAATTTATCAAGAAGAACGAACGTCTCGATTTATCGAACATTAAACCTATACAGCTCAAACCAAAAATAGCCGAGCAAGCTCAAACAAAAGCTGCCGACAAGCCAAAGATTACTCCTGTAGAATTTGAAGAGCAATTAGTGTTCCATGCTCCCGCCTCTATTCCGTTTGACAAACTGAGTGAATCATTGAACTCTTTCATGAAAGAAGCTTACCAGTTCTCACACGGAACACCACTAATGGACACAAATTCGAAATACTTTGACCCTATTTTCGAGGACCTTGTCACCTTGAGCCCAAGAGAGCCAAGATTTAAATTTTCCTATGACTTGATGCAAATTCCCAAAGCTAATAACATGCAAGACACGTACGGTCAAGAAGACATATTTGACCTCTTAACAGGTTCAGACGCGACTGCCTCATCAGTAAGACCCGTTGAAAAGAACTTACCTGAAAAAAACGAATATATACTAGCGTTGAATGTTAGCGTCAACAACAAGAAGTTTAATGACGCGGAGGCCAAGGCAAAAAGATTCCTTGATTACGTAAGGGAGTTAGAATCATTTTGA","protein_sequence":"MLSAISKVSTLKSCTRYLTKCNYHASAKLLAVKTFSMPAMSPTMEKGGIVSWKYKVGEPFSAGDVILEVETDKSQIDVEALDDGKLAKILKDEGSKDVDVGEPIAYIADVDDDLATIKLPQEANTANAKSIEIKKPSADSTEATQQHLKKATVTPIKTVDGSQANLEQTLLPSVSLLLAENNISKQKALKEIAPSGSNGRLLKGDVLAYLGKIPQDSVNKVTEFIKKNERLDLSNIKPIQLKPKIAEQAQTKAADKPKITPVEFEEQLVFHAPASIPFDKLSESLNSFMKEAYQFSHGTPLMDTNSKYFDPIFEDLVTLSPREPRFKFSYDLMQIPKANNMQDTYGQEDIFDLLTGSDATASSVRPVEKNLPEKNEYILALNVSVNNKKFNDAEAKAKRFLDYVRELESF"}]}