{"ymdb_id":"YMDB00071","created_at":"2011-05-29T15:53:54.000Z","updated_at":"2016-09-08T18:34:58.000Z","name":"2-Ketobutyric acid","cas":"600-18-0","state":"Solid","melting_point":"33oC ","description":"Alpha-Ketoglutaric acid (2-oxobutanoate, 2-keto-butyrate) is a key intermediate in the Krebs cycle. It is involved in the metabolism of many amino acids (glycine, methionine, valine, leucine, serine, threonine, isoleucine) as well as propanoate metabolism and C-5 branched dibasic acid metabolism. It can be converted to propionyl-CoA and thus enter the citric acid cycle.","experimental_water_solubility":"119 mg/mL [HMP experimental]","experimental_logp_hydrophobicity":"","location":"mitochondrion;cytoplasm","synthesis_reference":"Figge, Rainer; Lux, Fabien; Raynaud, Celine; Soucaille, Philippe. Production of a-ketobutyrate by engineered Escherichia coli.PCT Int. Appl.  (2006), 31pp.  ","chebi_id":"30831","hmdb_id":"HMDB00005","kegg_id":"C00109","pubchem_id":"58","cs_id":"57","foodb_id":null,"wikipedia_link":"Alpha-ketobutyric_acid","biocyc_id":"2-OXOBUTANOATE","iupac":"2-oxobutanoic acid","traditional_iupac":"2-oxobutanoic acid","logp":"0.7664098003333332","pka":null,"alogps_solubility":"7.92e+01 g/l","alogps_logp":"0.07","alogps_logs":"-0.11","acceptor_count":"3","donor_count":"1","rotatable_bond_count":"2","polar_surface_area":"54.37","refractivity":"22.616600000000002","polarizability":"9.1994455800129","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-9.650960797412663","pka_strongest_acidic":"3.1869864284881544","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-Ketobutanoate","2-Ketobutanoic acid","2-ketobutyrate","2-ketobutyric acid","2-Oxo-Butanoate","2-Oxo-Butanoic acid","2-oxo-Butyrate","2-oxo-Butyric acid","2-Oxo-n-butyrate","2-Oxo-n-butyric acid","2-Oxobutanoate","2-Oxobutanoic acid","2-Oxobutyrate","2-Oxobutyric acid","3-Methylpyruvate","3-Methylpyruvic acid","a-keto-n-Butyrate","a-keto-n-Butyric acid","a-Ketobutyrate","a-Ketobutyric acid","a-Oxo-n-butyrate","a-Oxo-n-butyric acid","a-Oxobutyrate","a-Oxobutyric acid","alpha-Keto-n-butyrate","alpha-Keto-n-butyric acid","alpha-Ketobutric acid","alpha-Ketobutyrate","alpha-Ketobutyric acid","alpha-Oxo-n-butyrate","alpha-Oxo-n-butyric acid","alpha-Oxobutyrate","alpha-Oxobutyric acid","Butanoic acid, 2-oxo-","Butyric acid, 2-oxo-","Formic acid, propionyl-","Ketobutyrate","methyl-Pyruvate","methyl-Pyruvic acid","Oxobutyrate","propionyl-formate","propionyl-formic acid","Pyruvic acid, methyl-"],"pathways":[{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Sulfur metabolism","kegg_map_id":"00920"},{"name":"isoleucine biosynthesis","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":14607989,"citation":"Yamagata, S., Yasugahira, T., Okuda, Y., Iwama, T. (2003). \"Conversion of the aminocrotonate intermediate limits the rate of gamma-elimination reaction catalyzed by L-cystathionine gamma-lyase of the yeast Saccharomyces cerevisiae.\" J Biochem 134:607-613."},{"pubmed_id":8972574,"citation":"Cullin, C., Baudin-Baillieu, A., Guillemet, E., Ozier-Kalogeropoulos, O. (1996). \"Functional analysis of YCL09C: evidence for a role as the regulatory subunit of acetolactate synthase.\" Yeast 12:1511-1518."}],"proteins":[{"created_at":"2011-05-24T20:27:16.000Z","updated_at":"2011-07-22T17:53:52.000Z","name":"Pyruvate decarboxylase isozyme 3","uniprot_id":"P26263","uniprot_name":"PDC6_YEAST","enzyme":true,"transporter":false,"gene_name":"PDC6","num_residues":563,"molecular_weight":"61579.89844","theoretical_pi":"6.11","general_function":"Involved in magnesium ion binding","specific_function":"Minor of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids valine, isoleucine, phenylalanine, and tryptophan, whereas leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins. The expression level of this protein in the presence of fermentable carbon sources is so low that it can not compensate for the other two pyruvate decarboxylases to sustain fermentation","reactions":[{"id":1184,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1186,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1228,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1658,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1841,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1933,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1934,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2319,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm;Nucleus","altext":"A 2-oxo acid = an aldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2320,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2321,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Phenylpyruvate = phenylacetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2322,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Pyruvate = Acetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2323,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"A 2-oxo acid + an aldehyde = A 2-hydroxy ketone + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2324,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"An aldehyde + an aldehyde = A 2-hydroxy ketone.","export":false,"pw_reaction_id":null,"source":null},{"id":14096,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006520","source":"Smpdb"},{"id":14097,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006525","source":"Smpdb"},{"id":14098,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006537","source":"Smpdb"},{"id":14099,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006557","source":"Smpdb"},{"id":14100,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006971","source":"Smpdb"},{"id":14101,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006979","source":"Smpdb"},{"id":14283,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006759","source":"Smpdb"},{"id":14285,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006770","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X55905","genbank_protein_id":"4116","gene_card_id":"PDC6","chromosome_location":"chromosome 7","locus":"YGR087C","synonyms":[],"enzyme_classes":["4.1.1.-","4.1.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" thiamin pyrophosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TPP_enzyme_C","identifier":"PF02775"},{"name":"TPP_enzyme_M","identifier":"PF00205"},{"name":"TPP_enzyme_N","identifier":"PF02776"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Ethanol fermentation","kegg_map_id":null},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Valine Biosynthesis","kegg_map_id":null},{"name":"Valine Degradation","kegg_map_id":null},{"name":"isoleucine biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTCTGAAATTACTCTTGGAAAATACTTATTTGAAAGATTGAAGCAAGTTAATGTTAACACCATTTTTGGGCTACCAGGCGACTTCAACTTGTCCCTATTGGACAAGATTTACGAGGTAGATGGATTGAGATGGGCTGGTAATGCAAATGAGCTGAACGCCGCCTATGCCGCCGATGGTTACGCACGCATCAAGGGTTTATCTGTGCTGGTAACTACTTTTGGCGTAGGTGAATTATCCGCCTTGAATGGTATTGCAGGATCGTATGCAGAACACGTCGGTGTACTGCATGTTGTTGGTGTCCCCTCTATCTCCGCTCAGGCTAAGCAATTGTTGTTGCATCATACCTTGGGTAACGGTGATTTTACCGTTTTTCACAGAATGTCCGCCAATATCTCAGAAACTACATCAATGATTACAGACATTGCTACAGCCCCTTCAGAAATCGATAGGTTGATCAGGACAACATTTATAACACAAAGGCCTAGCTACTTGGGGTTGCCAGCGAATTTGGTAGATCTAAAGGTTCCTGGTTCTCTTTTGGAAAAACCGATTGATCTATCATTAAAACCTAACGATCCCGAAGCTGAAAAGGAAGTTATTGATACCGTACTAGAATTGATCCAGAATTCGAAAAACCCTGTTATACTATCGGATGCCTGTGCTTCTAGGCACAACGTTAAAAAAGAAACCCAGAAGTTAATTGATTTGACGCAATTCCCAGCTTTTGTGACACCTCTAGGTAAAGGGTCAATAGATGAACAGCATCCCAGATATGGCGGTGTTTATGTGGGAACGCTGTCCAAACAAGACGTGAAACAGGCCGTTGAGTCGGCTGATTTGATCCTTTCGGTCGGTGCTTTGCTCTCTGATTTTAACACAGGTTCGTTTTCCTACTCCTACAAGACTAAAAATGTAGTGGAGTTTCATTCCGATTACGTAAAGGTGAAGAACGCTACGTTCCTCGGTGTACAAATGAAATTTGCACTACAAAACTTACTGAAGGTTATTCCCGATGTTGTTAAGGGCTACAAGAGCGTTCCCGTACCAACCAAAACTCCCGCAAACAAAGGTGTACCTGCTAGCACGCCCTTGAAACAAGAGTGGTTGTGGAACGAATTGTCCAAATTCTTGCAAGAAGGTGATGTTATCATTTCCGAGACCGGCACGTCTGCCTTCGGTATCAATCAAACTATCTTTCCTAAGGACGCCTACGGTATCTCGCAGGTGTTGTGGGGGTCCATCGGTTTTACAACAGGAGCAACTTTAGGTGCTGCCTTTGCCGCTGAGGAGATTGACCCCAACAAGAGAGTCATCTTATTCATAGGTGACGGGTCTTTGCAGTTAACCGTCCAAGAAATCTCCACCATGATCAGATGGGGGTTAAAGCCGTATCTTTTTGTCCTTAACAACGACGGCTACACTATCGAAAAGCTGATTCATGGGCCTCACGCAGAGTACAACGAAATCCAGACCTGGGATCACCTCGCCCTGTTGCCCGCATTTGGTGCGAAAAAGTACGAAAATCACAAGATCGCCACTACGGGTGAGTGGGATGCCTTAACCACTGATTCAGAGTTCCAGAAAAACTCGGTGATCAGACTAATTGAACTGAAACTGCCCGTCTTTGATGCTCCGGAAAGTTTGATCAAACAAGCGCAATTGACTGCCGCTACAAATGCCAAACAATAA","protein_sequence":"MSEITLGKYLFERLKQVNVNTIFGLPGDFNLSLLDKIYEVDGLRWAGNANELNAAYAADGYARIKGLSVLVTTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTVFHRMSANISETTSMITDIATAPSEIDRLIRTTFITQRPSYLGLPANLVDLKVPGSLLEKPIDLSLKPNDPEAEKEVIDTVLELIQNSKNPVILSDACASRHNVKKETQKLIDLTQFPAFVTPLGKGSIDEQHPRYGGVYVGTLSKQDVKQAVESADLILSVGALLSDFNTGSFSYSYKTKNVVEFHSDYVKVKNATFLGVQMKFALQNLLKVIPDVVKGYKSVPVPTKTPANKGVPASTPLKQEWLWNELSKFLQEGDVIISETGTSAFGINQTIFPKDAYGISQVLWGSIGFTTGATLGAAFAAEEIDPNKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIHGPHAEYNEIQTWDHLALLPAFGAKKYENHKIATTGEWDALTTDSEFQKNSVIRLIELKLPVFDAPESLIKQAQLTAATNAKQ"},{"created_at":"2011-05-26T16:29:03.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"Putative cystathionine gamma-synthase YML082W","uniprot_id":"Q04533","uniprot_name":"METX_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":649,"molecular_weight":"74312.70313","theoretical_pi":"5.02","general_function":"Involved in pyridoxal phosphate binding","specific_function":"O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate","reactions":[{"id":1421,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1801,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2421,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z46660","genbank_protein_id":"575721","gene_card_id":null,"chromosome_location":null,"locus":"YML082W","synonyms":["O-succinylhomoserine (thiol)-lyase"],"enzyme_classes":["2.5.1.48"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGGTTTCAGCGCAAGTGGCTACCGAGCTAGGACAGCCTATACCACTGGACACTCAACATGCGGTATCTGTATGTTTCCCGACATGGAAATCTGTAATTTCGTATGTGGAGAAAGACCCCAAAGTTTTAGGGTGTTTAAAGTCTGGCTACCCCAGGTTTTGGATCCACCCCTCGATTCAAAAGCTGCGTGATATTTTAATAGAAAAGTATGCTAAAGAAAACGAAACGTGCTTTTGCTTCCCCTCTTATAGAGTTGCCAAACGGTGCAGAGAGTATGTAAGAAGGAAGTGCGCGCATCGCAATGGCAAAGTAAGGATATTACAGTTAGCCACGGCGAAACCTATCAACGAGGAGCAGAAGACGTGGAAAAGAGAGTGTAAGATTGCGGTAGTGTTTGTAGATGGGGCATACGAGAATATATTAAAACAGTATTGGCAATACACCGGAGAGATCATCTCAAGCAGACTAGCTGAATATGTTTTGCATGAACTTTTCATGGTAGAAAAGAAATCCAGCCCTGCAGAGGAAAAGGAATACATAGAGATGCGGTATGGCAGGAATCTGAATTTTGCATTTGCCGATCGAGCCAAGGAATTGATTAAGAAGAGGATCGCTACAAAGGTTATAGATAAAGATGAGCACGATGAGGAGGAAAACTACCATTTCTTAGCAGGTAACCAAGATGAACAGGACTTCCAGGACACGTTTCTGGATTCATCCCTCAATGAGGCTAACCACGGAGAAGATCATGACGGCGGGATTAGCGGTGAAGTAGACAGTCAAGAAGAACCGCATAATGGCCTTGTTTCCACTATACCCCCGGAGCCCATCGAAATGAGCACGATAGAGGAAGAGCAATCCGTAGAGGAAGATGCCGGGAGGTGTGCATTAAGGGTTTGCCCTGAGAGAGACGTTTTTTTGTTTCCGAGCGGCATGGCGTCGATATTCACTGCGCATAGATTGCTGTTGCAATGGGACTCACTGCGTTTGAATAGATCCAGAAATGGAAGCGACGTCACCTCGTCACCTCCGAATAAGAAGACCGTGATTTTTGGGTTCCCTTATGCGGATACATTACATGTCTTGCAAGAGTTTAATGAAACGTATTTCTTGGGAGAAGGAGATGAGTCTTCAATGAAAGAACTAACAAAAATTTTACATTCCGGGGAGCAAATTCTTGCCGTTTTTATAGAGACCCCATCAAACCCACTATTAAAAATGGGAAATTTACTGGAACTGAAAAGGCTTTCGGAATTATTTGGGTTTTTCATTATCATTGATGAAACTGTGGGTGGAATAGTTAATATTGACGGTCTACCGTTTGCTGATATCGTTTGCAGTTCATTGACGAAGACATTTAGTGGGGACTCTAACGTCATTGGTGGTTCAATGGTTTTAAATCCACAAAGCCGGGTATACGAGTTTGCCTCCCGTTTTATGCAATTAGAAGACGAATATGAAGATTTATTATGGTGCGAAGACGCAATTTACCTGGAAAGAAATTCCAGAGATTTCATTGCTAGAACCATCAGGATCAACTACAGCACCGAATACCTCTTAGATAAAATACTGAAGCCACACGTAGGCGAAAATAAACTATTCAAGAAAATCTACTACCCTAATCTAACCTCAAAAGAAACACTAACCAACTATGACATGGTGAGGTGTAAGAAAGAAGGTGGATACGGCGGGCTCTTTTCACTAACGTTCCATGACGAAGATCATGCTGCGGCCTTTTATGACAATCTAAAGCTGAACAAGGGTCCTTCCTTGGGCACAAATTTCACACTCGCATTCCCCTATACGCTCATGACATACTACCACGAACTCGACATGGCTGAAAAATTTGGGGTTGAGAGAAATCTTCTCAGAATCAGCGTAGGCCTCGAAAGTCAGTCAATATTGGGCAAGATCTTCCAAGAGGCAATTGATAAAACGGTAGAAATATGA","protein_sequence":"MVSAQVATELGQPIPLDTQHAVSVCFPTWKSVISYVEKDPKVLGCLKSGYPRFWIHPSIQKLRDILIEKYAKENETCFCFPSYRVAKRCREYVRRKCAHRNGKVRILQLATAKPINEEQKTWKRECKIAVVFVDGAYENILKQYWQYTGEIISSRLAEYVLHELFMVEKKSSPAEEKEYIEMRYGRNLNFAFADRAKELIKKRIATKVIDKDEHDEEENYHFLAGNQDEQDFQDTFLDSSLNEANHGEDHDGGISGEVDSQEEPHNGLVSTIPPEPIEMSTIEEEQSVEEDAGRCALRVCPERDVFLFPSGMASIFTAHRLLLQWDSLRLNRSRNGSDVTSSPPNKKTVIFGFPYADTLHVLQEFNETYFLGEGDESSMKELTKILHSGEQILAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPFADIVCSSLTKTFSGDSNVIGGSMVLNPQSRVYEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFIARTIRINYSTEYLLDKILKPHVGENKLFKKIYYPNLTSKETLTNYDMVRCKKEGGYGGLFSLTFHDEDHAAAFYDNLKLNKGPSLGTNFTLAFPYTLMTYYHELDMAEKFGVERNLLRISVGLESQSILGKIFQEAIDKTVEI"},{"created_at":"2011-05-26T16:31:10.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"Cystathionine gamma-lyase","uniprot_id":"P31373","uniprot_name":"CYS3_YEAST","enzyme":true,"transporter":false,"gene_name":"CYS3","num_residues":394,"molecular_weight":"42541.69922","theoretical_pi":"6.52","general_function":"Involved in pyridoxal phosphate binding","specific_function":"L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate","reactions":[{"id":1420,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2423,"direction":"\u003e","locations":"Cytoplasm","altext":"L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate.","export":false,"pw_reaction_id":null,"source":null},{"id":3779,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006300","source":"Smpdb"},{"id":3780,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006305","source":"Smpdb"},{"id":14294,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006775","source":"Smpdb"},{"id":14295,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006796","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1N8P","cellular_location":"Cytoplasm","genbank_gene_id":"D14135","genbank_protein_id":"416164","gene_card_id":"CYS3","chromosome_location":"chromosome 1","locus":"YAL012W","synonyms":["Gamma-cystathionase","Sulfur transfer protein 1"],"enzyme_classes":["4.4.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGACTCTACAAGAATCTGATAAATTTGCTACCAAGGCCATTCATGCCGGTGAACATGTGGACGTTCACGGTTCCGTGATCGAACCCATTTCTTTGTCCACCACTTTCAAACAATCTTCTCCAGCTAACCCTATCGGTACTTACGAATACTCCAGATCTCAAAATCCTAACAGAGAGAACTTGGAAAGAGCAGTTGCCGCTTTAGAGAACGCTCAATACGGGTTGGCTTTCTCCTCTGGTTCTGCCACCACCGCCACAATCTTGCAATCGCTTCCTCAGGGCTCCCATGCGGTCTCTATCGGTGATGTGTACGGTGGTACCCACAGATACTTCACCAAAGTCGCCAACGCTCACGGTGTGGAAACCTCCTTCACTAACGATTTGTTGAACGATCTACCTCAATTGATAAAGGAAAACACCAAATTGGTCTGGATCGAAACCCCAACCAACCCAACTTTGAAGGTCACCGACATCCAAAAGGTGGCAGACCTTATCAAGAAGCACGCTGCCGGCCAAGACGTGATCTTGGTTGTCGACAACACCTTCTTGTCCCCATATATCTCCAATCCATTGAACTTCGGTGCAGACATCGTTGTCCACTCCGCTACAAAGTACATCAACGGTCACTCAGACGTTGTGCTCGGTGTCCTGGCCACTAATAACAAGCCATTGTACGAGCGTCTGCAGTTCTTACAAAACGCCATTGGTGCTATCCCATCTCCTTTCGATGCTTGGTTGACCCACAGAGGTTTGAAGACTTTGCATCTACGTGTCAGACAAGCTGCCCTCAGCGCCAACAAAATCGCTGAATTCTTGGCAGCAGACAAGGAAAACGTTGTCGCAGTCAACTACCCAGGTTTGAAGACACACCCTAACTACGACGTAGTGTTAAAGCAACACCGTGATGCCCTTGGTGGTGGTATGATCTCCTTCAGAATCAAGGGTGGTGCTGAAGCTGCTTCCAAGTTCGCCTCCTCCACAAGACTGTTCACATTGGCCGAATCCCTTGGTGGTATCGAATCTCTATTGGAAGTGCCCGCTGTGATGACCCACGGTGGTATCCCAAAGGAGGCCAGAGAGGCCTCTGGTGTTTTTGACGACTTGGTTAGAATCTCTGTCGGTATTGAAGACACTGACGATCTTTTGGAAGACATCAAGCAAGCCTTGAAACAAGCCACCAACTAA","protein_sequence":"MTLQESDKFATKAIHAGEHVDVHGSVIEPISLSTTFKQSSPANPIGTYEYSRSQNPNRENLERAVAALENAQYGLAFSSGSATTATILQSLPQGSHAVSIGDVYGGTHRYFTKVANAHGVETSFTNDLLNDLPQLIKENTKLVWIETPTNPTLKVTDIQKVADLIKKHAAGQDVILVVDNTFLSPYISNPLNFGADIVVHSATKYINGHSDVVLGVLATNNKPLYERLQFLQNAIGAIPSPFDAWLTHRGLKTLHLRVRQAALSANKIAEFLAADKENVVAVNYPGLKTHPNYDVVLKQHRDALGGGMISFRIKGGAEAASKFASSTRLFTLAESLGGIESLLEVPAVMTHGGIPKEAREASGVFDDLVRISVGIEDTDDLLEDIKQALKQATN"},{"created_at":"2011-05-26T17:02:57.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Threonine dehydratase, mitochondrial","uniprot_id":"P00927","uniprot_name":"THDH_YEAST","enzyme":true,"transporter":false,"gene_name":"ILV1","num_residues":576,"molecular_weight":"63830.69922","theoretical_pi":"8.77","general_function":"Involved in catalytic activity","specific_function":"L-threonine = 2-oxobutanoate + NH(3)","reactions":[{"id":1706,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2460,"direction":"\u003e","locations":"Mitochondrion","altext":"L-threonine = 2-oxobutanoate + NH(3).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"M36383","genbank_protein_id":"171752","gene_card_id":"ILV1","chromosome_location":"chromosome 5","locus":"YER086W","synonyms":["Threonine deaminase"],"enzyme_classes":["4.3.1.19"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" carbon-nitrogen lyase activity"},{"category":"Function","description":" ammonia-lyase activity"},{"category":"Function","description":" L-threonine ammonia-lyase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" branched chain family amino acid metabolic process"},{"category":"Process","description":" isoleucine metabolic 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L-serine/threonine dehydratase","uniprot_id":"P25379","uniprot_name":"STDH_YEAST","enzyme":true,"transporter":false,"gene_name":"CHA1","num_residues":360,"molecular_weight":"39301.0","theoretical_pi":"9.01","general_function":"Involved in catalytic activity","specific_function":"L-serine = pyruvate + NH(3)","reactions":[{"id":1703,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1706,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2461,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"L-serine = pyruvate + NH(3).","export":false,"pw_reaction_id":null,"source":null},{"id":2460,"direction":"\u003e","locations":"Mitochondrion","altext":"L-threonine = 2-oxobutanoate + 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L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3787,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006309","source":"Smpdb"},{"id":3788,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006518","source":"Smpdb"},{"id":3789,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006523","source":"Smpdb"},{"id":3790,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006536","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U10398","genbank_protein_id":"500670","gene_card_id":"ARO9","chromosome_location":"chromosome 8","locus":"YHR137W","synonyms":["Aromatic amino acid aminotransferase II","Aromatic amino acid-requiring protein 9"],"enzyme_classes":["2.6.1.57"],"go_classes":[{"category":"Component","description":" Not 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metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACTGCTGGTTCTGCCCCCCCTGTTGATTACACTTCCTTAAAGAAGAACTTCCAACCGTTTCTCTCCAGAAGAGTAGAAAATAGATCTCTGAAAAGCTTTTGGGATGCTTCTGATATCTCAGATGACGTCATTGAGCTAGCTGGTGGAATGCCAAACGAGAGATTTTTTCCTATCGAATCTATGGATTTGAAAATATCAAAAGTTCCTTTTAATGATAACCCAAAATGGCATAATTCGTTTACCACGGCGCATTTGGACTTGGGATCCCCCAGTGAGCTACCCATTGCACGTTCTTTCCAATATGCAGAAACCAAGGGTTTACCCCCTCTCTTACATTTTGTTAAAGATTTTGTGTCCAGAATTAATCGCCCAGCCTTTTCCGATGAGACGGAGTCTAACTGGGATGTCATCCTTTCTGGCGGGTCCAACGATTCAATGTTTAAGGTTTTTGAAACAATTTGCGACGAATCGACCACTGTGATGATTGAAGAGTTTACTTTCACCCCGGCTATGTCCAATGTGGAGGCTACAGGAGCAAAAGTCATCCCCATCAAGATGAACCTGACCTTCGACAGAGAGTCCCAGGGTATTGATGTCGAATATCTAACGCAGTTGCTCGATAATTGGTCAACTGGACCATACAAAGACTTAAACAAGCCAAGGGTCCTATATACCATTGCAACGGGCCAAAATCCTACCGGGATGTCTGTCCCCCAGTGGAAAAGAGAGAAAATTTACCAGTTGGCCCAAAGACACGATTTCCTCATTGTTGAAGATGATCCCTACGGTTATCTGTACTTTCCTTCCTATAATCCGCAAGAGCCATTAGAAAACCCTTACCATTCTAGCGACCTGACTACTGAACGGTATTTGAATGATTTTTTAATGAAATCATTCTTGACTTTGGATACAGATGCCCGTGTCATCCGTTTGGAGACTTTTTCTAAAATTTTTGCTCCTGGATTAAGGTTATCCTTCATCGTTGCTAATAAATTCCTTTTGCAAAAAATCTTGGATTTGGCCGACATTACTACAAGGGCCCCCAGTGGTACCTCACAAGCTATTGTTTATTCTACAATAAAGGCAATGGCTGAGTCCAACTTATCGTCCTCTCTTTCTATGAAAGAAGCAATGTTTGAGGGTTGGATAAGATGGATAATGCAGATTGCTTCTAAATACAATCATAGGAAAAATCTTACTTTGAAAGCCTTATACGAAACAGAATCTTACCAAGCTGGTCAGTTTACCGTTATGGAACCCTCCGCGGGTATGTTCATCATTATTAAAATCAATTGGGGGAATTTCGATAGACCTGACGATTTGCCGCAACAGATGGATATTTTAGATAAGTTCTTGCTGAAGAATGGTGTTAAAGTAGTGCTTGGTTATAAAATGGCTGTTTGCCCAAATTATTCAAAGCAGAATTCAGATTTTCTAAGACTCACCATCGCCTATGCAAGGGATGATGATCAGTTGATTGAAGCTTCCAAAAGAATCGGTAGTGGCATAAAAGAATTTTTTGACAACTATAAAAGTTGA","protein_sequence":"MTAGSAPPVDYTSLKKNFQPFLSRRVENRSLKSFWDASDISDDVIELAGGMPNERFFPIESMDLKISKVPFNDNPKWHNSFTTAHLDLGSPSELPIARSFQYAETKGLPPLLHFVKDFVSRINRPAFSDETESNWDVILSGGSNDSMFKVFETICDESTTVMIEEFTFTPAMSNVEATGAKVIPIKMNLTFDRESQGIDVEYLTQLLDNWSTGPYKDLNKPRVLYTIATGQNPTGMSVPQWKREKIYQLAQRHDFLIVEDDPYGYLYFPSYNPQEPLENPYHSSDLTTERYLNDFLMKSFLTLDTDARVIRLETFSKIFAPGLRLSFIVANKFLLQKILDLADITTRAPSGTSQAIVYSTIKAMAESNLSSSLSMKEAMFEGWIRWIMQIASKYNHRKNLTLKALYETESYQAGQFTVMEPSAGMFIIIKINWGNFDRPDDLPQQMDILDKFLLKNGVKVVLGYKMAVCPNYSKQNSDFLRLTIAYARDDDQLIEASKRIGSGIKEFFDNYKS"},{"created_at":"2011-05-27T03:16:08.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Acetolactate 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activity"},{"category":"Function","description":" thiamin pyrophosphate binding"},{"category":"Function","description":" transferase activity, transferring aldehyde or ketonic groups"},{"category":"Function","description":" acetolactate synthase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" branched chain family amino acid biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"TPP_enzyme_C","identifier":"PF02775"},{"name":"TPP_enzyme_M","identifier":"PF00205"},{"name":"TPP_enzyme_N","identifier":"PF02776"}],"pathways":[{"name":"Valine, leucine and isoleucine biosynthesis","kegg_map_id":"00290"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Pantothenate and CoA biosynthesis","kegg_map_id":"00770"}],"gene_sequence":"ATGATCAGACAATCTACGCTAAAAAACTTCGCTATTAAGCGTTGCTTTCAACATATAGCATACCGCAACACACCTGCCATGAGATCAGTAGCTCTCGCGCAGCGCTTTTATAGTTCGTCTTCCCGTTATTACAGTGCGTCTCCATTACCAGCCTCTAAAAGGCCAGAGCCTGCTCCAAGTTTCAATGTTGATCCATTAGAACAGCCCGCTGAACCTTCAAAATTGGCTAAGAAACTACGCGCTGAGCCTGACATGGATACCTCTTTCGTCGGTTTAACTGGTGGTCAAATATTTAACGAAATGATGTCCAGACAAAACGTTGATACTGTATTTGGTTATCCAGGTGGTGCTATCCTACCTGTTTACGATGCCATTCATAACAGTGATAAATTCAACTTCGTTCTTCCAAAACACGAACAAGGTGCCGGTCACATGGCAGAAGGCTACGCCAGAGCTTCTGGTAAACCAGGTGTTGTCTTGGTTACTTCTGGGCCAGGTGCCACCAATGTCGTTACTCCAATGGCAGATGCCTTTGCAGACGGGATTCCAATGGTTGTCTTTACAGGGCAAGTCCCAACTAGTGCTATCGGTACTGATGCTTTCCAAGAGGCTGACGTCGTTGGTATTTCTAGATCTTGTACGAAATGGAATGTCATGGTCAAGTCCGTGGAAGAATTGCCATTGCGTATTAACGAGGCTTTTGAAATTGCCACGAGCGGTAGACCGGGACCAGTCTTGGTCGATTTACCAAAGGATGTTACAGCAGCTATCTTAAGAAATCCAATTCCAACAAAAACAACTCTTCCATCAAACGCACTAAACCAATTAACCAGTCGCGCACAAGATGAATTTGTCATGCAAAGTATCAATAAAGCAGCAGATTTGATCAACTTGGCAAAGAAACCTGTCTTATACGTCGGTGCTGGTATTTTAAACCATGCAGATGGTCCAAGATTACTAAAAGAATTAAGTGACCGTGCTCAAATACCTGTCACCACTACTTTACAAGGTTTAGGTTCATTCGACCAAGAAGATCCAAAATCATTGGATATGCTTGGTATGCACGGTTGTGCTACTGCCAACCTGGCAGTGCAAAATGCCGACTTGATAATTGCAGTTGGTGCTAGATTCGACGACCGTGTCACTGGTAATATTTCTAAATTCGCTCCAGAAGCTCGTCGTGCAGCTGCCGAGGGTAGAGGTGGTATTATTCATTTCGAGGTTAGTCCAAAAAACATAAACAAGGTTGTTCAAACTCAAATAGCAGTGGAAGGTGATGCTACGACCAATCTGGGCAAAATGATGTCAAAGATTTTCCCAGTTAAGGAGAGGTCTGAATGGTTTGCTCAAATAAATAAATGGAAGAAGGAATACCCATACGCTTATATGGAGGAGACTCCAGGATCTAAAATTAAACCACAGACGGTTATAAAGAAACTATCCAAGGTTGCCAACGACACAGGAAGACATGTCATTGTTACAACGGGTGTGGGGCAACATCAAATGTGGGCTGCTCAACACTGGACATGGAGAAATCCACATACTTTCATCACATCAGGTGGTTTAGGTACGATGGGTTACGGTCTCCCTGCCGCCATCGGTGCTCAAGTTGCAAAGCCAGAATCTTTGGTTATTGACATTGATGGTGACGCATCCTTTAACATGACTCTAACGGAATTGAGTTCTGCCGTTCAAGCTGGTACTCCAGTGAAGATTTTGATTTTGAACAATGAAGAGCAAGGTATGGTTACTCAATGGCAATCCCTGTTCTACGAACATCGTTATTCCCACACACATCAATTGAACCCTGATTTCATAAAACTAGCGGAGGCTATGGGTTTAAAAGGTTTAAGAGTCAAGAAGCAAGAGGAATTGGACGCTAAGTTGAAAGAATTCGTTTCTACCAAGGGCCCAGTTTTGCTTGAAGTGGAAGTTGATAAAAAAGTTCCTGTTTTGCCAATGGTGGCAGGTGGTAGCGGTCTAGACGAGTTCATAAATTTTGACCCAGAAGTTGAAAGACAACAGACTGAATTACGTCATAAGCGTACAGGCGGTAAGCACTGA","protein_sequence":"MIRQSTLKNFAIKRCFQHIAYRNTPAMRSVALAQRFYSSSSRYYSASPLPASKRPEPAPSFNVDPLEQPAEPSKLAKKLRAEPDMDTSFVGLTGGQIFNEMMSRQNVDTVFGYPGGAILPVYDAIHNSDKFNFVLPKHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQEADVVGISRSCTKWNVMVKSVEELPLRINEAFEIATSGRPGPVLVDLPKDVTAAILRNPIPTKTTLPSNALNQLTSRAQDEFVMQSINKAADLINLAKKPVLYVGAGILNHADGPRLLKELSDRAQIPVTTTLQGLGSFDQEDPKSLDMLGMHGCATANLAVQNADLIIAVGARFDDRVTGNISKFAPEARRAAAEGRGGIIHFEVSPKNINKVVQTQIAVEGDATTNLGKMMSKIFPVKERSEWFAQINKWKKEYPYAYMEETPGSKIKPQTVIKKLSKVANDTGRHVIVTTGVGQHQMWAAQHWTWRNPHTFITSGGLGTMGYGLPAAIGAQVAKPESLVIDIDGDASFNMTLTELSSAVQAGTPVKILILNNEEQGMVTQWQSLFYEHRYSHTHQLNPDFIKLAEAMGLKGLRVKKQEELDAKLKEFVSTKGPVLLEVEVDKKVPVLPMVAGGSGLDEFINFDPEVERQQTELRHKRTGGKH"}]}