{"ymdb_id":"YMDB00958","created_at":"2011-06-03T15:40:32.000Z","updated_at":"2016-09-08T18:36:05.000Z","name":"(4-hydroxyphenyl)pyruvic acid","cas":"156-39-8","state":"Solid","melting_point":"219-220 oC","description":"4-Hydroxyphenylpyruvic acid (4-HPPA) is a keto acid. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase [EC 1.1.1.222] and is formed during tyrosine metabolism. There are two isomers of HPPA, specifically 4HPPA and 3HPPA, of which 4HPPA is the most common. The enzyme 4-hydroxyphenylpyruvic acid dioxygenase (HPD) catalyzes the reaction of 4-hydroxyphenylpyruvic acid to homogentisic acid in the tyrosine catabolism pathway. [KEGG]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"mitochondrion;peroxisome;cytoplasm","synthesis_reference":null,"chebi_id":"15999","hmdb_id":"HMDB00707","kegg_id":"C01179","pubchem_id":"979","cs_id":"954","foodb_id":null,"wikipedia_link":"4-Hydroxyphenylpyruvic_acid","biocyc_id":"P-HYDROXY-PHENYLPYRUVATE","iupac":"3-(4-hydroxyphenyl)-2-oxopropanoic acid","traditional_iupac":"4-hydroxyphenylpyruvic acid","logp":"1.596648451333333","pka":"9.498853206830276","alogps_solubility":"1.49e+00 g/l","alogps_logp":"1.12","alogps_logs":"-2.08","acceptor_count":"4","donor_count":"2","rotatable_bond_count":"3","polar_surface_area":"74.60000000000001","refractivity":"44.6925","polarizability":"16.750960680327967","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"-5.958513128269975","pka_strongest_acidic":"2.91496710599853","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"1","veber_rule":"0","mddr_like_rule":"0","synonyms":["(p-hydroxyphenyl)-Pyruvate","(p-hydroxyphenyl)-Pyruvic acid","(p-Hydroxyphenyl)pyruvate","(p-Hydroxyphenyl)pyruvic acid","3-(4-HYDROXY-PHENYL)PYRUVIC ACID","3-(4-hydroxyphenyl)-2-oxo-propanoate","3-(4-hydroxyphenyl)-2-oxo-propanoic acid","3-(4-Hydroxyphenyl)-2-oxopropanoic acid","3-(4-Hydroxyphenyl)-2-oxopropionate","3-(4-Hydroxyphenyl)-2-oxopropionic acid","3-(4-Hydroxyphenyl)pyruvate","3-(4-Hydroxyphenyl)pyruvic acid","3-(p-Hydroxyphenyl)-2-oxopropanoic acid","3-(p-Hydroxyphenyl)-2-oxopropionate","3-(p-Hydroxyphenyl)-2-oxopropionic acid","3-(p-Hydroxyphenyl)pyruvate","3-(p-Hydroxyphenyl)pyruvic acid","4-hydroxy alpha-oxobenzenepropanoic acid","4-Hydroxy-a-oxobenzenepropanoate","4-Hydroxy-a-oxobenzenepropanoic acid","4-Hydroxy-alpha-oxobenzenepropanoate","4-Hydroxy-alpha-oxobenzenepropanoic acid","4-hydroxyphenylpyruvate","4-Hydroxyphenylpyruvic acid","4HPPA","Benzenepropanoic acid, 4-hydroxy-.alpha.-oxo-","HPP","HPPA","Hydroxyphenylpyruvate","Hydroxyphenylpyruvic acid","p-hydroxyphenylpyruvic","p-hydroxyphenylpyruvic acid","Pyruvic acid, (p-hydroxyphenyl)-"],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Ubiquinone and other terpenoid-quinone biosynthesis","kegg_map_id":"00130"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":2697638,"citation":"Mannhaupt, G., Stucka, R., Pilz, U., Schwarzlose, C., Feldmann, H. (1989). \"Characterization of the prephenate dehydrogenase-encoding gene, TYR1, from Saccharomyces cerevisiae.\" Gene 85:303-311."},{"pubmed_id":9491083,"citation":"Iraqui, I., Vissers, S., Cartiaux, M., Urrestarazu, A. (1998). \"Characterisation of Saccharomyces cerevisiae ARO8 and ARO9 genes encoding aromatic aminotransferases I and II reveals a new aminotransferase subfamily.\" Mol Gen Genet 257:238-248."}],"proteins":[{"created_at":"2011-05-24T20:26:42.000Z","updated_at":"2011-07-22T17:53:52.000Z","name":"Pyruvate decarboxylase isozyme 2","uniprot_id":"P16467","uniprot_name":"PDC5_YEAST","enzyme":true,"transporter":false,"gene_name":"PDC5","num_residues":563,"molecular_weight":"61911.60156","theoretical_pi":"6.4","general_function":"Involved in magnesium ion binding","specific_function":"Second most abundant of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids valine, isoleucine, phenylalanine, and tryptophan, whereas leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins","reactions":[{"id":1184,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1186,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1228,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1658,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1841,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1933,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1934,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2319,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm;Nucleus","altext":"A 2-oxo acid = an aldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2320,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2321,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Phenylpyruvate = phenylacetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2322,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Pyruvate = Acetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2323,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"A 2-oxo acid + an aldehyde = A 2-hydroxy ketone + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2324,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"An aldehyde + an aldehyde = A 2-hydroxy ketone.","export":false,"pw_reaction_id":null,"source":null},{"id":14096,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006520","source":"Smpdb"},{"id":14097,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006525","source":"Smpdb"},{"id":14098,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006537","source":"Smpdb"},{"id":14099,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006557","source":"Smpdb"},{"id":14100,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006971","source":"Smpdb"},{"id":14101,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006979","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U53881","genbank_protein_id":"1256902","gene_card_id":"PDC5","chromosome_location":"chromosome 12","locus":"YLR134W","synonyms":[],"enzyme_classes":["4.1.1.-","4.1.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" thiamin pyrophosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TPP_enzyme_C","identifier":"PF02775"},{"name":"TPP_enzyme_M","identifier":"PF00205"},{"name":"TPP_enzyme_N","identifier":"PF02776"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Ethanol fermentation","kegg_map_id":null},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Valine Degradation","kegg_map_id":null}],"gene_sequence":"ATGTCTGAAATAACCTTAGGTAAATATTTATTTGAAAGATTGAGCCAAGTCAACTGTAACACCGTCTTCGGTTTGCCAGGTGACTTTAACTTGTCTCTTTTGGATAAGCTTTATGAAGTCAAAGGTATGAGATGGGCTGGTAACGCTAACGAATTGAACGCTGCCTATGCTGCTGATGGTTACGCTCGTATCAAGGGTATGTCCTGTATTATTACCACCTTCGGTGTTGGTGAATTGTCTGCTTTGAATGGTATTGCCGGTTCTTACGCTGAACATGTCGGTGTTTTGCACGTTGTTGGTGTTCCATCCATCTCTTCTCAAGCTAAGCAATTGTTGTTGCATCATACCTTGGGTAACGGTGACTTCACTGTTTTCCACAGAATGTCTGCCAACATTTCTGAAACCACTGCCATGATCACTGATATTGCTAACGCTCCAGCTGAAATTGACAGATGTATCAGAACCACCTACACTACCCAAAGACCAGTCTACTTGGGTTTGCCAGCTAACTTGGTTGACTTGAACGTCCCAGCCAAGTTATTGGAAACTCCAATTGACTTGTCTTTGAAGCCAAACGACGCTGAAGCTGAAGCTGAAGTTGTTAGAACTGTTGTTGAATTGATCAAGGATGCTAAGAACCCAGTTATCTTGGCTGATGCTTGTGCTTCTAGACATGATGTCAAGGCTGAAACTAAGAAGTTGATGGACTTGACTCAATTCCCAGTTTACGTCACCCCAATGGGTAAGGGTGCTATTGACGAACAACACCCAAGATACGGTGGTGTTTACGTTGGTACCTTGTCTAGACCAGAAGTTAAGAAGGCTGTAGAATCTGCTGATTTGATATTGTCTATCGGTGCTTTGTTGTCTGATTTCAATACCGGTTCTTTCTCTTACTCCTACAAGACCAAAAATATCGTTGAATTCCACTCTGACCACATCAAGATCAGAAACGCCACCTTCCCAGGTGTTCAAATGAAATTTGCCTTGCAAAAATTGTTGGATGCTATTCCAGAAGTCGTCAAGGACTACAAACCTGTTGCTGTCCCAGCTAGAGTTCCAATTACCAAGTCTACTCCAGCTAACACTCCAATGAAGCAAGAATGGATGTGGAACCATTTGGGTAACTTCTTGAGAGAAGGTGATATTGTTATTGCTGAAACCGGTACTTCCGCCTTCGGTATTAACCAAACTACTTTCCCAACAGATGTATACGCTATCGTCCAAGTCTTGTGGGGTTCCATTGGTTTCACAGTCGGCGCTCTATTGGGTGCTACTATGGCCGCTGAAGAACTTGATCCAAAGAAGAGAGTTATTTTATTCATTGGTGACGGTTCTCTACAATTGACTGTTCAAGAAATCTCTACCATGATTAGATGGGGTTTGAAGCCATACATTTTTGTCTTGAATAACAACGGTTACACCATTGAAAAATTGATTCACGGTCCTCATGCCGAATATAATGAAATTCAAGGTTGGGACCACTTGGCCTTATTGCCAACTTTTGGTGCTAGAAACTACGAAACCCACAGAGTTGCTACCACTGGTGAATGGGAAAAGTTGACTCAAGACAAGGACTTCCAAGACAACTCTAAGATTAGAATGATTGAAGTTATGTTGCCAGTCTTTGATGCTCCACAAAACTTGGTTAAACAAGCTCAATTGACTGCCGCTACTAACGCTAAACAATAA","protein_sequence":"MSEITLGKYLFERLSQVNCNTVFGLPGDFNLSLLDKLYEVKGMRWAGNANELNAAYAADGYARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISSQAKQLLLHHTLGNGDFTVFHRMSANISETTAMITDIANAPAEIDRCIRTTYTTQRPVYLGLPANLVDLNVPAKLLETPIDLSLKPNDAEAEAEVVRTVVELIKDAKNPVILADACASRHDVKAETKKLMDLTQFPVYVTPMGKGAIDEQHPRYGGVYVGTLSRPEVKKAVESADLILSIGALLSDFNTGSFSYSYKTKNIVEFHSDHIKIRNATFPGVQMKFALQKLLDAIPEVVKDYKPVAVPARVPITKSTPANTPMKQEWMWNHLGNFLREGDIVIAETGTSAFGINQTTFPTDVYAIVQVLWGSIGFTVGALLGATMAAEELDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYIFVLNNNGYTIEKLIHGPHAEYNEIQGWDHLALLPTFGARNYETHRVATTGEWEKLTQDKDFQDNSKIRMIEVMLPVFDAPQNLVKQAQLTAATNAKQ"},{"created_at":"2011-05-24T20:27:16.000Z","updated_at":"2011-07-22T17:53:52.000Z","name":"Pyruvate decarboxylase isozyme 3","uniprot_id":"P26263","uniprot_name":"PDC6_YEAST","enzyme":true,"transporter":false,"gene_name":"PDC6","num_residues":563,"molecular_weight":"61579.89844","theoretical_pi":"6.11","general_function":"Involved in magnesium ion binding","specific_function":"Minor of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-keto-acids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids valine, isoleucine, phenylalanine, and tryptophan, whereas leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins. The expression level of this protein in the presence of fermentable carbon sources is so low that it can not compensate for the other two pyruvate decarboxylases to sustain fermentation","reactions":[{"id":1184,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1186,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1228,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1658,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1841,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1933,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1934,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2319,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm;Nucleus","altext":"A 2-oxo acid = an aldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2320,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2321,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Phenylpyruvate = phenylacetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2322,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Pyruvate = Acetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2323,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"A 2-oxo acid + an aldehyde = A 2-hydroxy ketone + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2324,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"An aldehyde + an aldehyde = A 2-hydroxy ketone.","export":false,"pw_reaction_id":null,"source":null},{"id":14096,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006520","source":"Smpdb"},{"id":14097,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006525","source":"Smpdb"},{"id":14098,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006537","source":"Smpdb"},{"id":14099,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006557","source":"Smpdb"},{"id":14100,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006971","source":"Smpdb"},{"id":14101,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006979","source":"Smpdb"},{"id":14283,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006759","source":"Smpdb"},{"id":14285,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006770","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X55905","genbank_protein_id":"4116","gene_card_id":"PDC6","chromosome_location":"chromosome 7","locus":"YGR087C","synonyms":[],"enzyme_classes":["4.1.1.-","4.1.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" thiamin pyrophosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TPP_enzyme_C","identifier":"PF02775"},{"name":"TPP_enzyme_M","identifier":"PF00205"},{"name":"TPP_enzyme_N","identifier":"PF02776"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Ethanol fermentation","kegg_map_id":null},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Valine Biosynthesis","kegg_map_id":null},{"name":"Valine Degradation","kegg_map_id":null},{"name":"isoleucine biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTCTGAAATTACTCTTGGAAAATACTTATTTGAAAGATTGAAGCAAGTTAATGTTAACACCATTTTTGGGCTACCAGGCGACTTCAACTTGTCCCTATTGGACAAGATTTACGAGGTAGATGGATTGAGATGGGCTGGTAATGCAAATGAGCTGAACGCCGCCTATGCCGCCGATGGTTACGCACGCATCAAGGGTTTATCTGTGCTGGTAACTACTTTTGGCGTAGGTGAATTATCCGCCTTGAATGGTATTGCAGGATCGTATGCAGAACACGTCGGTGTACTGCATGTTGTTGGTGTCCCCTCTATCTCCGCTCAGGCTAAGCAATTGTTGTTGCATCATACCTTGGGTAACGGTGATTTTACCGTTTTTCACAGAATGTCCGCCAATATCTCAGAAACTACATCAATGATTACAGACATTGCTACAGCCCCTTCAGAAATCGATAGGTTGATCAGGACAACATTTATAACACAAAGGCCTAGCTACTTGGGGTTGCCAGCGAATTTGGTAGATCTAAAGGTTCCTGGTTCTCTTTTGGAAAAACCGATTGATCTATCATTAAAACCTAACGATCCCGAAGCTGAAAAGGAAGTTATTGATACCGTACTAGAATTGATCCAGAATTCGAAAAACCCTGTTATACTATCGGATGCCTGTGCTTCTAGGCACAACGTTAAAAAAGAAACCCAGAAGTTAATTGATTTGACGCAATTCCCAGCTTTTGTGACACCTCTAGGTAAAGGGTCAATAGATGAACAGCATCCCAGATATGGCGGTGTTTATGTGGGAACGCTGTCCAAACAAGACGTGAAACAGGCCGTTGAGTCGGCTGATTTGATCCTTTCGGTCGGTGCTTTGCTCTCTGATTTTAACACAGGTTCGTTTTCCTACTCCTACAAGACTAAAAATGTAGTGGAGTTTCATTCCGATTACGTAAAGGTGAAGAACGCTACGTTCCTCGGTGTACAAATGAAATTTGCACTACAAAACTTACTGAAGGTTATTCCCGATGTTGTTAAGGGCTACAAGAGCGTTCCCGTACCAACCAAAACTCCCGCAAACAAAGGTGTACCTGCTAGCACGCCCTTGAAACAAGAGTGGTTGTGGAACGAATTGTCCAAATTCTTGCAAGAAGGTGATGTTATCATTTCCGAGACCGGCACGTCTGCCTTCGGTATCAATCAAACTATCTTTCCTAAGGACGCCTACGGTATCTCGCAGGTGTTGTGGGGGTCCATCGGTTTTACAACAGGAGCAACTTTAGGTGCTGCCTTTGCCGCTGAGGAGATTGACCCCAACAAGAGAGTCATCTTATTCATAGGTGACGGGTCTTTGCAGTTAACCGTCCAAGAAATCTCCACCATGATCAGATGGGGGTTAAAGCCGTATCTTTTTGTCCTTAACAACGACGGCTACACTATCGAAAAGCTGATTCATGGGCCTCACGCAGAGTACAACGAAATCCAGACCTGGGATCACCTCGCCCTGTTGCCCGCATTTGGTGCGAAAAAGTACGAAAATCACAAGATCGCCACTACGGGTGAGTGGGATGCCTTAACCACTGATTCAGAGTTCCAGAAAAACTCGGTGATCAGACTAATTGAACTGAAACTGCCCGTCTTTGATGCTCCGGAAAGTTTGATCAAACAAGCGCAATTGACTGCCGCTACAAATGCCAAACAATAA","protein_sequence":"MSEITLGKYLFERLKQVNVNTIFGLPGDFNLSLLDKIYEVDGLRWAGNANELNAAYAADGYARIKGLSVLVTTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTVFHRMSANISETTSMITDIATAPSEIDRLIRTTFITQRPSYLGLPANLVDLKVPGSLLEKPIDLSLKPNDPEAEKEVIDTVLELIQNSKNPVILSDACASRHNVKKETQKLIDLTQFPAFVTPLGKGSIDEQHPRYGGVYVGTLSKQDVKQAVESADLILSVGALLSDFNTGSFSYSYKTKNVVEFHSDYVKVKNATFLGVQMKFALQNLLKVIPDVVKGYKSVPVPTKTPANKGVPASTPLKQEWLWNELSKFLQEGDVIISETGTSAFGINQTIFPKDAYGISQVLWGSIGFTTGATLGAAFAAEEIDPNKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIHGPHAEYNEIQTWDHLALLPAFGAKKYENHKIATTGEWDALTTDSEFQKNSVIRLIELKLPVFDAPESLIKQAQLTAATNAKQ"},{"created_at":"2011-05-24T20:31:18.000Z","updated_at":"2011-07-22T17:53:52.000Z","name":"Pyruvate decarboxylase isozyme 1","uniprot_id":"P06169","uniprot_name":"PDC1_YEAST","enzyme":true,"transporter":false,"gene_name":"PDC1","num_residues":563,"molecular_weight":"61494.89844","theoretical_pi":"6.11","general_function":"Involved in magnesium ion binding","specific_function":"Major of three pyruvate decarboxylases (PDC1, PDC5, PDC6) implicated in the nonoxidative conversion of pyruvate to acetaldehyde and carbon dioxide during alcoholic fermentation. Most of the produced acetaldehyde is subsequently reduced to ethanol, but some is required for cytosolic acetyl-CoA production for biosynthetic pathways. The enzyme is also one of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) able to decarboxylate more complex 2-oxo acids (alpha-ketoacids) than pyruvate, which seem mainly involved in amino acid catabolism. Here the enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids. In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its preferred substrates are the transaminated amino acids valine, isoleucine, phenylalanine, and tryptophan, whereas leucine is no substrate. In a side-reaction the carbanionic intermediate (or active aldehyde) generated by decarboxylation or by activation of an aldehyde can react with an aldehyde via condensation (or carboligation) yielding a 2-hydroxy ketone, collectively called acyloins","reactions":[{"id":1184,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1186,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1228,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1658,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1841,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1933,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1934,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2319,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm;Nucleus","altext":"A 2-oxo acid = an aldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2320,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2321,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Phenylpyruvate = phenylacetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2322,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Pyruvate = Acetaldehyde + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2323,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"A 2-oxo acid + an aldehyde = A 2-hydroxy ketone + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2324,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"An aldehyde + an aldehyde = A 2-hydroxy ketone.","export":false,"pw_reaction_id":null,"source":null},{"id":14096,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006520","source":"Smpdb"},{"id":14097,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006525","source":"Smpdb"},{"id":14098,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006537","source":"Smpdb"},{"id":14099,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006557","source":"Smpdb"},{"id":14100,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006971","source":"Smpdb"},{"id":14101,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006979","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1QPB","cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"X77316","genbank_protein_id":"871533","gene_card_id":"PDC1","chromosome_location":"chromosome 12","locus":"YLR044C","synonyms":[],"enzyme_classes":["4.1.1.-","4.1.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" vitamin binding"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" thiamin pyrophosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"TPP_enzyme_C","identifier":"PF02775"},{"name":"TPP_enzyme_M","identifier":"PF00205"},{"name":"TPP_enzyme_N","identifier":"PF02776"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Ethanol fermentation","kegg_map_id":null},{"name":"Isoleucine degradation","kegg_map_id":null},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Valine Degradation","kegg_map_id":null}],"gene_sequence":"ATGTCTGAAATTACTTTGGGTAAATATTTGTTCGAAAGATTAAAGCAAGTCAACGTTAACACCGTTTTCGGTTTGCCAGGTGACTTCAACTTGTCCTTGTTGGACAAGATCTACGAAGTTGAAGGTATGAGATGGGCTGGTAACGCCAACGAATTGAACGCTCGTTACGCCGCTGATGGTTACGCTCGTATCAAGGGTATGTCTTGTATCATCACCACCTTCGGTGTCGGTGAATTGTCTGCTTTGAACGGTATTGCCGGTTCTTACGCTGAACACGTCGGTGTTTTGCACGTTGTTGGTGTCCCATCCATCTCTTCTCAAGCTAAGCAATTGTTGTTGCACCACACCTTGGGTAACGGTGACTTCACTGTTTTCCACAGAATGTCTGCCAACATTTCTGAAACCACTGCTATGATCACTGACATCTGTACCGCCCCAGCTGAAATTGACAGATGTATCAGAACCACTTACGTCACCCAAAGACCAGTCTACTTAGGTTTGCCAGCTAACTTGGTCGACTTGAACGTCCCAGCTAAGTTGTTGCAAACTCCAATTGACATGTCTTTGAAGCCAAACGATGCTGAATCCGAAAAGGAAGTCATTGACACCATCTTGGTCTTGGCTAAGGATGCTAAGAACCCAGTTATCTTGGCTGATGCTTGTTGTTCCAGACACGACGTCAAGGCTGAAACTAAGAAGTTGATTGACTTGACTCAATTCCCAGCTTTCGTCACCCCAATGGGTAAGGGTTCCATTAGCGAACAACACCCAAGATACGGTGGTGTTTACGTCGGTACCTTGTCCAAGCCAGAAGTTAAGGAAGCCGTTGAATCTGCTGACTTGATTTTGTCTGTCGGTGCTTTGTTGTCTGATTTCAACACCGGTTCTTTCTCTTACTCTTACAAGACCAAGAACATTGTCGAATTCCACTCCGACCACATGAAGATCAGAAACGCCACTTTCCCAGGTGTCCAAATGAAATTCGTTTTGCAAAAGTTGTTGACCAATATTGCTGACGCCGCTAAGGGTTACAAGCCAGTTGCTGTCCCAGCTAGAACTCCAGCTAACGCTGCTGTCCCAGCTTCTACCCCATTGAAGCAAGAATGGATGTGGAACCAATTGGGTAACTTCTTGCAAGAAGGTGATGTTGTCATTGCTGAAACCGGTACCTCCGCTTTCGGTATCAACCAAACCACTTTCCCAAACAACACCTACGGTATCTCTCAAGTCTTATGGGGTTCCATTGGTTTCACCACTGGTGCTACCTTGGGTGCTGCTTTCGCTGCTGAAGAAATTGATCCAAAGAAGAGAGTTATCTTATTCATTGGTGACGGTTCTTTGCAATTGACTGTTCAAGAAATCTCCACCATGATCAGATGGGGCTTGAAGCCATACTTGTTCGTCTTGAACAACGATGGTTACACCATTGAAAAGTTGATTCACGGTCCAAAGGCTCAATACAACGAAATTCAAGGTTGGGACCACCTATCCTTGTTGCCAACTTTCGGTGCTAAGGACTACGAAACCCACAGAGTCGCTACCACCGGTGAATGGGACAAGTTGACCCAAGACAAGTCTTTCAACGACAACTCTAAGATCAGAATGATTGAGGTTATGTTGCCAGTCTTCGATGCTCCACAAAACTTGGTTGAACAAGCTAAGTTGACTGCTGCTACCAACGCTAAGCAATAA","protein_sequence":"MSEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIHGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEIMLPVFDAPQNLVEQAKLTAATNAKQ"},{"created_at":"2011-05-27T02:15:50.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Aromatic amino acid aminotransferase 2","uniprot_id":"P38840","uniprot_name":"ARO9_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO9","num_residues":513,"molecular_weight":"58527.0","theoretical_pi":"5.16","general_function":"Involved in transferase activity, transferring nitrogenous groups","specific_function":"Has aromatic amino acid transaminase activity and kynurenine aminotransferase activity","reactions":[{"id":1839,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2024,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2027,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2667,"direction":"\u003e","locations":"Cytoplasm","altext":"An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3787,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006309","source":"Smpdb"},{"id":3788,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006518","source":"Smpdb"},{"id":3789,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006523","source":"Smpdb"},{"id":3790,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006536","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U10398","genbank_protein_id":"500670","gene_card_id":"ARO9","chromosome_location":"chromosome 8","locus":"YHR137W","synonyms":["Aromatic amino acid aminotransferase II","Aromatic amino acid-requiring protein 9"],"enzyme_classes":["2.6.1.57"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" cofactor binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACTGCTGGTTCTGCCCCCCCTGTTGATTACACTTCCTTAAAGAAGAACTTCCAACCGTTTCTCTCCAGAAGAGTAGAAAATAGATCTCTGAAAAGCTTTTGGGATGCTTCTGATATCTCAGATGACGTCATTGAGCTAGCTGGTGGAATGCCAAACGAGAGATTTTTTCCTATCGAATCTATGGATTTGAAAATATCAAAAGTTCCTTTTAATGATAACCCAAAATGGCATAATTCGTTTACCACGGCGCATTTGGACTTGGGATCCCCCAGTGAGCTACCCATTGCACGTTCTTTCCAATATGCAGAAACCAAGGGTTTACCCCCTCTCTTACATTTTGTTAAAGATTTTGTGTCCAGAATTAATCGCCCAGCCTTTTCCGATGAGACGGAGTCTAACTGGGATGTCATCCTTTCTGGCGGGTCCAACGATTCAATGTTTAAGGTTTTTGAAACAATTTGCGACGAATCGACCACTGTGATGATTGAAGAGTTTACTTTCACCCCGGCTATGTCCAATGTGGAGGCTACAGGAGCAAAAGTCATCCCCATCAAGATGAACCTGACCTTCGACAGAGAGTCCCAGGGTATTGATGTCGAATATCTAACGCAGTTGCTCGATAATTGGTCAACTGGACCATACAAAGACTTAAACAAGCCAAGGGTCCTATATACCATTGCAACGGGCCAAAATCCTACCGGGATGTCTGTCCCCCAGTGGAAAAGAGAGAAAATTTACCAGTTGGCCCAAAGACACGATTTCCTCATTGTTGAAGATGATCCCTACGGTTATCTGTACTTTCCTTCCTATAATCCGCAAGAGCCATTAGAAAACCCTTACCATTCTAGCGACCTGACTACTGAACGGTATTTGAATGATTTTTTAATGAAATCATTCTTGACTTTGGATACAGATGCCCGTGTCATCCGTTTGGAGACTTTTTCTAAAATTTTTGCTCCTGGATTAAGGTTATCCTTCATCGTTGCTAATAAATTCCTTTTGCAAAAAATCTTGGATTTGGCCGACATTACTACAAGGGCCCCCAGTGGTACCTCACAAGCTATTGTTTATTCTACAATAAAGGCAATGGCTGAGTCCAACTTATCGTCCTCTCTTTCTATGAAAGAAGCAATGTTTGAGGGTTGGATAAGATGGATAATGCAGATTGCTTCTAAATACAATCATAGGAAAAATCTTACTTTGAAAGCCTTATACGAAACAGAATCTTACCAAGCTGGTCAGTTTACCGTTATGGAACCCTCCGCGGGTATGTTCATCATTATTAAAATCAATTGGGGGAATTTCGATAGACCTGACGATTTGCCGCAACAGATGGATATTTTAGATAAGTTCTTGCTGAAGAATGGTGTTAAAGTAGTGCTTGGTTATAAAATGGCTGTTTGCCCAAATTATTCAAAGCAGAATTCAGATTTTCTAAGACTCACCATCGCCTATGCAAGGGATGATGATCAGTTGATTGAAGCTTCCAAAAGAATCGGTAGTGGCATAAAAGAATTTTTTGACAACTATAAAAGTTGA","protein_sequence":"MTAGSAPPVDYTSLKKNFQPFLSRRVENRSLKSFWDASDISDDVIELAGGMPNERFFPIESMDLKISKVPFNDNPKWHNSFTTAHLDLGSPSELPIARSFQYAETKGLPPLLHFVKDFVSRINRPAFSDETESNWDVILSGGSNDSMFKVFETICDESTTVMIEEFTFTPAMSNVEATGAKVIPIKMNLTFDRESQGIDVEYLTQLLDNWSTGPYKDLNKPRVLYTIATGQNPTGMSVPQWKREKIYQLAQRHDFLIVEDDPYGYLYFPSYNPQEPLENPYHSSDLTTERYLNDFLMKSFLTLDTDARVIRLETFSKIFAPGLRLSFIVANKFLLQKILDLADITTRAPSGTSQAIVYSTIKAMAESNLSSSLSMKEAMFEGWIRWIMQIASKYNHRKNLTLKALYETESYQAGQFTVMEPSAGMFIIIKINWGNFDRPDDLPQQMDILDKFLLKNGVKVVLGYKMAVCPNYSKQNSDFLRLTIAYARDDDQLIEASKRIGSGIKEFFDNYKS"},{"created_at":"2011-05-27T02:16:21.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Aromatic amino acid aminotransferase 1","uniprot_id":"P53090","uniprot_name":"ARO8_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO8","num_residues":500,"molecular_weight":"56177.30078","theoretical_pi":"5.86","general_function":"Involved in transferase activity, transferring nitrogenous groups","specific_function":"Has aromatic amino acid transaminase activity. Also active with methionine, alpha-aminoadipate and leucine when phenylpyruvate is the amino acceptor","reactions":[{"id":1839,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2024,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2027,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2667,"direction":"\u003e","locations":"Cytoplasm","altext":"An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2668,"direction":"\u003e","locations":"Cytoplasm","altext":"L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate","export":false,"pw_reaction_id":null,"source":null},{"id":14093,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006519","source":"Smpdb"},{"id":14094,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006524","source":"Smpdb"},{"id":14095,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006535","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692962","genbank_protein_id":"51013375","gene_card_id":"ARO8","chromosome_location":"chromosome 7","locus":"YGL202W","synonyms":["Aromatic amino acid aminotransferase I","Aromatic amino acid-requiring protein 8"],"enzyme_classes":["2.6.1.57","2.6.1.39"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" cofactor binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACTTTACCTGAATCAAAAGACTTTTCTTACTTGTTTTCGGATGAAACCAATGCTCGTAAACCATCCCCATTGAAAACCTGCATCCATCTTTTCCAAGATCCTAACATTATCTTTTTGGGTGGTGGCCTGCCATTAAAAGATTATTTCCCATGGGATAATCTATCTGTAGATTCACCCAAGCCTCCTTTTCCCCAGGGTATTGGAGCTCCAATTGACGAGCAGAATTGCATAAAATACACCGTCAACAAAGATTACGCTGATAAAAGTGCCAATCCTTCCAACGATATTCCTTTGTCAAGAGCTTTGCAATACGGGTTCAGTGCTGGTCAACCTGAACTATTAAACTTCATTAGAGATCATACCAAGATTATCCACGATTTGAAGTATAAGGACTGGGACGTTTTAGCCACTGCAGGTAACACAAATGCCTGGGAATCTACTTTAAGAGTCTTTTGTAACCGAGGTGATGTCATCTTAGTTGAGGCACATTCTTTTTCCTCTTCATTGGCTTCTGCAGAGGCTCAAGGTGTCATTACCTTCCCCGTGCCAATTGACGCTGATGGTATCATTCCTGAAAAATTAGCTAAAGTCATGGAAAACTGGACACCTGGTGCTCCTAAACCAAAGTTGTTATACACTATTCCAACGGGCCAAAATCCAACTGGTACTTCCATTGCAGACCATAGAAAGGAGGCAATTTACAAGATCGCTCAAAAGTACGACTTCCTAATTGTGGAAGATGAACCTTATTATTTCTTACAAATGAATCCCTACATCAAAGACTTGAAGGAAAGAGAGAAGGCACAAAGTTCTCCAAAGCAGGACCATGACGAATTTTTGAAGTCCTTGGCAAACACTTTCCTTTCCTTGGATACAGAAGGCCGTGTTATTAGAATGGATTCCTTTTCAAAAGTTTTGGCCCCAGGGACAAGATTGGGTTGGATTACTGGTTCATCCAAAATCTTGAAGCCTTACTTGAGTTTGCATGAAATGACGATTCAAGCCCCAGCAGGTTTTACACAAGTTTTGGTCAACGCTACGCTATCCAGGTGGGGTCAAAAGGGTTACTTGGACTGGTTGCTTGGCCTGCGTCATGAATACACTTTGAAACGTGACTGTGCCATCGATGCCCTTTACAAGTATCTACCACAATCTGATGCTTTCGTGATCAATCCTCCAATTGCAGGTATGTTTTTCACCGTGAACATTGACGCATCTGTCCACCCTGAGTTTAAAACAAAATACAACTCAGACCCTTACCAGCTAGAACAGAGTCTTTACCACAAAGTGGTTGAACGTGGTGTTTTAGTGGTTCCCGGTTCTTGGTTCAAGAGTGAGGGTGAGACGGAACCTCCTCAACCCGCTGAATCTAAAGAAGTCAGTAATCCAAACATAATTTTCTTCAGAGGTACCTATGCAGCTGTCTCTCCTGAGAAACTGACTGAAGGTCTGAAGAGATTAGGTGATACTTTATACGAAGAATTTGGTATTTCCAAATAG","protein_sequence":"MTLPESKDFSYLFSDETNARKPSPLKTCIHLFQDPNIIFLGGGLPLKDYFPWDNLSVDSPKPPFPQGIGAPIDEQNCIKYTVNKDYADKSANPSNDIPLSRALQYGFSAGQPELLNFIRDHTKIIHDLKYKDWDVLATAGNTNAWESTLRVFCNRGDVILVEAHSFSSSLASAEAQGVITFPVPIDADGIIPEKLAKVMENWTPGAPKPKLLYTIPTGQNPTGTSIADHRKEAIYKIAQKYDFLIVEDEPYYFLQMNPYIKDLKEREKAQSSPKQDHDEFLKSLANTFLSLDTEGRVIRMDSFSKVLAPGTRLGWITGSSKILKPYLSLHEMTIQAPAGFTQVLVNATLSRWGQKGYLDWLLGLRHEYTLKRDCAIDALYKYLPQSDAFVINPPIAGMFFTVNIDASVHPEFKTKYNSDPYQLEQSLYHKVVERGVLVVPGSWFKSEGETEPPQPAESKEVSNPNIIFFRGTYAAVSPEKLTEGLKRLGDTLYEEFGISK"},{"created_at":"2011-05-27T02:39:39.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"Prephenate dehydrogenase [NADP+]","uniprot_id":"P20049","uniprot_name":"TYR1_YEAST","enzyme":true,"transporter":false,"gene_name":"TYR1","num_residues":452,"molecular_weight":"50922.89844","theoretical_pi":"6.57","general_function":"Involved in oxidoreductase activity","specific_function":"Prephenate + NADP(+) = 4-hydroxyphenylpyruvate + CO(2) + NADPH","reactions":[{"id":1910,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2683,"direction":"\u003e","locations":null,"altext":"Prephenate + NADP(+) = 4-hydroxyphenylpyruvate + CO(2) + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":14102,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006522","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z36035","genbank_protein_id":"536506","gene_card_id":"TYR1","chromosome_location":"chromosome 2","locus":"YBR166C","synonyms":["PRDH"],"enzyme_classes":["1.3.1.13","1.3.1.12"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" prephenate dehydrogenase (NADP+) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Process","description":" aromatic amino acid family metabolic process"},{"category":"Process","description":" tyrosine metabolic process"},{"category":"Process","description":" tyrosine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"PDH","identifier":"PF02153"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"}],"gene_sequence":"ATGGTATCAGAGGATAAGATTGAGCAATGGAAAGCCACAAAAGTCATTGGTATAATTGGTCTGGGTGATATGGGCCTATTATACGCTAATAAATTTACAGATGCTGGATGGGGTGTTATATGTTGTGATAGGGAAGAATATTATGATGAACTGAAAGAAAAATATGCCTCAGCTAAATTCGAACTGGTGAAAAATGGTCATTTGGTATCCAGGCAAAGCGACTATATTATCTATAGTGTTGAAGCATCCAATATTAGTAAGATCGTCGCAACGTATGGACCATCTTCTAAGGTTGGAACAATTGTTGGGGGTCAAACGAGTTGTAAGCTGCCGGAAATCGAGGCTTTCGAAAAGTATTTACCCAAGGACTGCGACATCATTACCGTGCATTCCCTTCATGGGCCTAAAGTTAATACTGAAGGCCAACCACTAGTTATTATCAATCACAGATCACAGTACCCAGAATCTTTTGAGTTCGTTAATTCTGTTATGGCATGTTTGAAAAGTAAGCAAGTTTATTTGACATATGAAGAGCATGACAAGATTACCGCTGATACACAAGCTGTGACACATGCTGCTTTCTTAAGTATGGGATCTGCGTGGGCAAAGATAAAGATTTATCCTTGGACTCTGGGTGTAAACAAATGGTACGGTGGCCTAGAAAATGTGAAAGTTAATATATCACTAAGAATCTATTCGAACAAGTGGCATGTTTACGCAGGATTAGCCATAACAAACCCAAGTGCACATCAGCAAATTCTTCAATATGCAACCAGTGCAACAGAACTATTTAGTTTAATGATAGATAACAAAGAACAAGAACTTACTGATAGACTATTAAAAGCTAAGCAATTTGTATTTGGAAAGCATACTGGTCTCTTACTATTGGATGACACGATTTTAGAGAAATATTCGCTATCAAAAAGCAGCATTGGTAACAGCAACAATTGCAAGCCAGTGCCGAATTCACATTTATCATTGTTGGCGATTGTTGATTCGTGGTTTCAACTTGGTATTGATCCATATGATCATATGATTTGTTCGACGCCATTATTCAGAATATTCCTGGGTGTGTCCGAATATCTTTTTTTAAAACCTGGCTTATTAGAACAGACAATTGATGCAGCTATCCATGATAAATCATTCATAAAAGATGATTTAGAATTTGTTATTTCGGCTAGAGAATGGAGCTCGGTTGTTTCTTTTGCCAATTTTGATATATACAAAAAGCAATTTCAGAGTGTTCAAAAGTTCTTTGAGCCAATGCTTCCAGAGGCTAATCTCATTGGCAACGAGATGATAAAAACCATTCTGAGTCATTCTAGTGACCGTTCGGCCGCTGAAAAAAGAAATACATAA","protein_sequence":"MVSEDKIEQWKATKVIGIIGLGDMGLLYANKFTDAGWGVICCDREEYYDELKEKYASAKFELVKNGHLVSRQSDYIIYSVEASNISKIVATYGPSSKVGTIVGGQTSCKLPEIEAFEKYLPKDCDIITVHSLHGPKVNTEGQPLVIINHRSQYPESFEFVNSVMACLKSKQVYLTYEEHDKITADTQAVTHAAFLSMGSAWAKIKIYPWTLGVNKWYGGLENVKVNISLRIYSNKWHVYAGLAITNPSAHQQILQYATSATELFSLMIDNKEQELTDRLLKAKQFVFGKHTGLLLLDDTILEKYSLSKSSIGNSNNCKPVPNSHLSLLAIVDSWFQLGIDPYDHMICSTPLFRIFLGVSEYLFLKPGLLEQTIDAAIHDKSFIKDDLEFVISAREWSSVVSFANFDIYKKQFQSVQKFFEPMLPEANLIGNEMIKTILSHSSDRSAAEKRNT"},{"created_at":"2011-05-27T02:45:42.000Z","updated_at":"2011-07-22T17:54:13.000Z","name":"Aspartate aminotransferase, mitochondrial","uniprot_id":"Q01802","uniprot_name":"AATM_YEAST","enzyme":true,"transporter":false,"gene_name":"AAT1","num_residues":451,"molecular_weight":"51795.10156","theoretical_pi":"9.22","general_function":"Involved in transferase activity, transferring nitrogenous groups","specific_function":"Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol","reactions":[{"id":1335,"direction":"\u003c\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1696,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2027,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2692,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm. 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Peroxisome.","altext":"L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1YAA","cellular_location":"Cytoplasm. Peroxisome.","genbank_gene_id":"Z73199","genbank_protein_id":"1360338","gene_card_id":"AAT2","chromosome_location":"chromosome 12","locus":"YLR027C","synonyms":["Transaminase A"],"enzyme_classes":["2.6.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"}],"gene_sequence":"ATGAACAAAAGAACACAGGAATACAAGAACACAAGAGCGATAATGTCTGCCACTCTGTTCAATAACATCGAATTGCTGCCCCCTGATGCCCTTTTTGGTATTAAGCAAAGGTACGGGCAAGATCAACGTGCTACCAAGGTCGACTTGGGTATCGGGGCCTACAGAGACGACAACGGTAAACCATGGGTCTTGCCAAGTGTTAAAGCCGCCGAAAAGCTAATTCATAACGACAGCTCCTACAACCATGAATACCTCGGTATTACCGGTCTGCCAAGTTTGACATCTAACGCCGCCAAGATCATCTTCGGTACGCAATCCGATGCCTTTCAGGAAGACAGAGTAATCTCAGTACAATCACTGTCTGGTACGGGTGCTCTTCATATATCTGCGAAGTTTTTTTCAAAATTCTTCCCAGATAAACTGGTCTATTTGTCTAAGCCTACTTGGGCCAACCACATGGCCATTTTTGAGAATCAAGGCTTGAAAACGGCGACTTACCCTTACTGGGCCAACGAAACTAAGTCTTTGGACCTAAACGGCTTTCTAAATGCTATTCAAAAAGCTCCAGAGGGCTCCATTTTCGTTCTGCACTCTTGCGCCCATAACCCAACTGGTCTGGACCCTACTAGTGAACAATGGGTTCAAATCGTTGATGCTATCGCCTCAAAGAACCACATCGCCTTATTTGACACCGCCTACCAAGGGTTTGCCACTGGAGATTTGGACAAGGATGCCTATGCTGTGCGTCTAGGTGTGGAGAAGCTTTCAACGGTCTCTCCCGTCTTTGTCTGTCAGTCCTTTGCCAAGAACGCCGGTATGTACGGTGAGCGTGTAGGTTGTTTCCATCTAGCACTTACAAAACAAGCTCAAAACAAAACTATAAAGCCTGCTGTTACATCTCAATTGGCCAAAATCATTCGTAGTGAAGTGTCCAACCCACCCGCCTACGGCGCTAAGATTGTCGCTAAACTGTTGGAAACGCCAGAATTAACGGAACAGTGGCACAAGGATATGGTTACCATGTCCTCCAGAATTACGAAAATGAGGCACGCATTAAGAGACCATTTAGTCAAGTTGGGCACTCCTGGCAACTGGGATCATATAGTAAATCAATGCGGGATGTTCTCCTTTACAGGATTGACTCCTCAAATGGTTAAACGACTTGAAGAAACCCACGCAGTTTACTTGGTTGCCTCAGGTAGAGCTTCTATTGCTGGATTGAATCAAGGAAACGTGGAATACGTGGCTAAAGCCATTGATGAAGTGGTGCGCTTCTATACTATTGAAGCTAAATTGTAA","protein_sequence":"MSATLFNNIELLPPDALFGIKQRYGQDQRATKVDLGIGAYRDDNGKPWVLPSVKAAEKLIHNDSSYNHEYLGITGLPSLTSNAAKIIFGTQSDAFQEDRVISVQSLSGTGALHISAKFFSKFFPDKLVYLSKPTWANHMAIFENQGLKTATYPYWANETKSLDLNGFLNAIQKAPEGSIFVLHSCAHNPTGLDPTSEQWVQIVDAIASKNHIALFDTAYQGFATGDLDKDAYAVRLGVEKLSTVSPVFVCQSFAKNAGMYGERVGCFHLALTKQAQNKTIKPAVTSQLAKIIRSEVSNPPAYGAKIVAKLLETPELTEQWHKDMVTMSSRITKMRHALRDHLVKLGTPGNWDHIVNQCGMFSFTGLTPQMVKRLEETHAVYLVASGRASIAGLNQGNVEYVAKAIDEVVRFYTIEAKL"}]}