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NAD (YMDB00110)
Identification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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YMDB ID | YMDB00110 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Name | NAD | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Species | Saccharomyces cerevisiae | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Strain | Baker's yeast | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Description | NAD, also known as beta-nad or NAD+, belongs to the class of organic compounds known as (5'->5')-dinucleotides. These are dinucleotides where the two bases are connected via a (5'->5')-phosphodiester linkage. NAD is a strong basic compound (based on its pKa). NAD exists in all living species, ranging from bacteria to humans. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Synonyms |
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CAS number | 53-84-9 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Weight | Average: 664.433 Monoisotopic: 664.116946663 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
InChI Key | BAWFJGJZGIEFAR-NNYOXOHSSA-O | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
InChI | InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p+1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IUPAC Name | 1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Traditional IUPAC Name | 1-[(2R,3R,4S,5R)-5-{[({[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxy]methyl}-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Chemical Formula | C21H28N7O14P2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SMILES | NC(=O)C1=CC=C[N+](=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Chemical Taxonomy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Description | belongs to the class of organic compounds known as (5'->5')-dinucleotides. These are dinucleotides where the two bases are connected via a (5'->5')-phosphodiester linkage. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kingdom | Organic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Super Class | Nucleosides, nucleotides, and analogues | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Class | (5'->5')-dinucleotides | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sub Class | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Direct Parent | (5'->5')-dinucleotides | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Alternative Parents |
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Substituents |
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Molecular Framework | Aromatic heteropolycyclic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
External Descriptors |
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Physical Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
State | Solid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Charge | 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Melting point | 140.0-142.0 °C | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Experimental Properties |
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Predicted Properties |
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Biological Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cellular Locations |
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Organoleptic Properties | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SMPDB Pathways |
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KEGG Pathways |
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SMPDB Reactions |
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KEGG Reactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Intracellular Concentrations |
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Extracellular Concentrations | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Spectra |
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References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
References: |
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Synthesis Reference: | Hughes, N. A.; Kenner, G. W.; Todd, Alexander. Codehydrogenases. III. Synthesis of diphosphopyridine nucleotide (cozymase) and triphosphopyridine nucleotide. Journal of the Chemical Society (1957), 3733-8. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
External Links: |
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Enzymes
- General function:
- Involved in catalytic activity
- Specific function:
- Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate
- Gene Name:
- GLT1
- Uniprot ID:
- Q12680
- Molecular weight:
- 238100.0
Reactions
2 L-glutamate + NAD(+) → L-glutamine + 2-oxoglutarate + NADH. |
- General function:
- Involved in NAD+ synthase (glutamine-hydrolyzing) activity
- Specific function:
- ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate
- Gene Name:
- QNS1
- Uniprot ID:
- P38795
- Molecular weight:
- 80684.89844
Reactions
ATP + deamido-NAD(+) + L-glutamine + H(2)O → AMP + diphosphate + NAD(+) + L-glutamate. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- D-arabinose + NAD(+) = D-arabinono-1,4-lactone + NADH
- Gene Name:
- ARA2
- Uniprot ID:
- Q04212
- Molecular weight:
- 38220.0
Reactions
D-arabinose + NAD(+) → D-arabinono-1,4-lactone + NADH. |
- General function:
- Involved in iron ion binding
- Specific function:
- Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol
- Gene Name:
- ERG11
- Uniprot ID:
- P10614
- Molecular weight:
- 60719.80078
Reactions
Obtusifoliol + 3 O(2) + 3 NADPH → 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP(+) + 4 H(2)O. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine
- Gene Name:
- LPD1
- Uniprot ID:
- P09624
- Molecular weight:
- 54009.69922
Reactions
Protein N(6)-(dihydrolipoyl)lysine + NAD(+) → protein N(6)-(lipoyl)lysine + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate
- Gene Name:
- LYS1
- Uniprot ID:
- P38998
- Molecular weight:
- 41464.39844
Reactions
N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD(+) + H(2)O → L-lysine + 2-oxoglutarate + NADH. |
- General function:
- Involved in zinc ion binding
- Specific function:
- An alcohol + NAD(+) = an aldehyde or ketone + NADH
- Gene Name:
- ADH3
- Uniprot ID:
- P07246
- Molecular weight:
- 40369.19922
Reactions
An alcohol + NAD(+) → an aldehyde or ketone + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H
- Gene Name:
- ALD2
- Uniprot ID:
- P47771
- Molecular weight:
- 55187.39844
Reactions
An aldehyde + NAD(P)(+) + H(2)O → an acid + NAD(P)H. |
- General function:
- Involved in zinc ion binding
- Specific function:
- Oxidizes long-chain alcohols and, in the presence of glutathione, is able to oxidize formaldehyde. Is responsible for yeast resistance to formaldehyde
- Gene Name:
- SFA1
- Uniprot ID:
- P32771
- Molecular weight:
- 41041.69922
Reactions
S-(hydroxymethyl)glutathione + NAD(P)(+) → S-formylglutathione + NAD(P)H. |
An alcohol + NAD(+) → an aldehyde or ketone + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- An aldehyde + NAD(+) + H(2)O = an acid + NADH
- Gene Name:
- ALD4
- Uniprot ID:
- P46367
- Molecular weight:
- 56723.19922
Reactions
An aldehyde + NAD(+) + H(2)O → an acid + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H
- Gene Name:
- ALD3
- Uniprot ID:
- P54114
- Molecular weight:
- 55384.80078
Reactions
An aldehyde + NAD(P)(+) + H(2)O → an acid + NAD(P)H. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- An aldehyde + NAD(+) + H(2)O = an acid + NADH
- Gene Name:
- ALD6
- Uniprot ID:
- P54115
- Molecular weight:
- 54413.69922
Reactions
An aldehyde + NAD(+) + H(2)O → an acid + NADH. |
- General function:
- Involved in zinc ion binding
- Specific function:
- This isozyme preferentially catalyzes the conversion of primary unbranched alcohols to their corresponding aldehydes. Also also shows activity toward secondary alcohols
- Gene Name:
- ADH1
- Uniprot ID:
- P00330
- Molecular weight:
- 36849.0
Reactions
An alcohol + NAD(+) → an aldehyde or ketone + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Minor mitochondrial aldehyde dehydrogenase isoform. Plays a role in regulation or biosynthesis of electron transport chain components. Involved in the biosynthesis of acetate during anaerobic growth on glucose
- Gene Name:
- ALD5
- Uniprot ID:
- P40047
- Molecular weight:
- 56620.39844
Reactions
An aldehyde + NAD(+) + H(2)O → an acid + NADH. |
An aldehyde + NADP(+) + H(2)O → an acid + NADPH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Reduces acetaldehyde to ethanol during glucose fermentation. Specific for ethanol. Shows drastically reduced activity towards primary alcohols from 4 carbon atoms upward. Isomers of aliphatic alcohol, as well as secondary alcohols and glycerol are not used at all
- Gene Name:
- ADH4
- Uniprot ID:
- P10127
- Molecular weight:
- 41141.69922
Reactions
An alcohol + NAD(+) → an aldehyde or ketone + NADH. |
- General function:
- Involved in zinc ion binding
- Specific function:
- An alcohol + NAD(+) = an aldehyde or ketone + NADH
- Gene Name:
- ADH5
- Uniprot ID:
- P38113
- Molecular weight:
- 37647.89844
Reactions
An alcohol + NAD(+) → an aldehyde or ketone + NADH. |
- General function:
- Involved in zinc ion binding
- Specific function:
- This isozyme preferentially catalyzes the conversion of ethanol to acetaldehyde. Acts on a variety of primary unbranched aliphatic alcohols
- Gene Name:
- ADH2
- Uniprot ID:
- P00331
- Molecular weight:
- 36731.60156
Reactions
An alcohol + NAD(+) → an aldehyde or ketone + NADH. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'- untranslated leaders of mitochondrial mRNAs
- Gene Name:
- IDH1
- Uniprot ID:
- P28834
- Molecular weight:
- 39323.69922
Reactions
Isocitrate + NAD(+) → 2-oxoglutarate + CO(2) + NADH. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'- untranslated leaders of mitochondrial mRNAs
- Gene Name:
- IDH2
- Uniprot ID:
- P28241
- Molecular weight:
- 39739.0
Reactions
Isocitrate + NAD(+) → 2-oxoglutarate + CO(2) + NADH. |
- General function:
- Involved in acyl-CoA dehydrogenase activity
- Specific function:
- Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2)
- Gene Name:
- POX1
- Uniprot ID:
- P13711
- Molecular weight:
- 84041.39844
Reactions
Acyl-CoA + O(2) → trans-2,3-dehydroacyl-CoA + H(2)O(2). |
- General function:
- Involved in transferase activity, transferring acyl groups other than amino-acyl groups
- Specific function:
- Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA
- Gene Name:
- POT1
- Uniprot ID:
- P27796
- Molecular weight:
- 44729.89844
Reactions
Acyl-CoA + acetyl-CoA → CoA + 3-oxoacyl-CoA. |
- General function:
- Involved in transferase activity
- Specific function:
- Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for:[acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase
- Gene Name:
- FAS1
- Uniprot ID:
- P07149
- Molecular weight:
- 228689.0
Reactions
Acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH → long-chain-acyl-CoA + n CoA + n CO(2) + 2n NAD(+) + 2n NADP(+). |
Acetyl-CoA + [acyl-carrier-protein] → CoA + acetyl-[acyl-carrier-protein]. |
Malonyl-CoA + [acyl-carrier-protein] → CoA + malonyl-[acyl-carrier-protein]. |
(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] → hexadec-2-enoyl-[acyl-carrier-protein] + H(2)O. |
Acyl-[acyl-carrier-protein] + NAD(+) → trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH. |
Oleoyl-[acyl-carrier-protein] + H(2)O → [acyl-carrier-protein] + oleate. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for:acyl carrier protein, 3- oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl- carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex
- Gene Name:
- FAS2
- Uniprot ID:
- P19097
- Molecular weight:
- 206945.0
Reactions
Acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH → long-chain-acyl-CoA + n CoA + n CO(2) + 2n NAD(+) + 2n NADP(+). |
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] → 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]. |
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) → 3-oxoacyl-[acyl-carrier-protein] + NADPH. |
- General function:
- Involved in acyltransferase activity
- Specific function:
- The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
- Gene Name:
- PDA2
- Uniprot ID:
- P12695
- Molecular weight:
- 51817.5
Reactions
Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine → CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Maintains high levels of reduced glutathione in the cytosol
- Gene Name:
- GLR1
- Uniprot ID:
- P41921
- Molecular weight:
- 53440.60156
Reactions
2 glutathione + NADP(+) → glutathione disulfide + NADPH. |
- General function:
- Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- Specific function:
- 3-phospho-D-glycerate + NAD(+) = 3- phosphonooxypyruvate + NADH
- Gene Name:
- SER33
- Uniprot ID:
- P40510
- Molecular weight:
- 51187.80078
Reactions
3-phospho-D-glycerate + NAD(+) → 3-phosphonooxypyruvate + NADH. |
2-hydroxyglutarate + NAD(+) → 2-oxoglutarate + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the production and accumulation of glycerol during hyperosmotic stress conditions. Glycerol acts as a osmoregulator that prevents loss of water and turgor of the cells
- Gene Name:
- GPD1
- Uniprot ID:
- Q00055
- Molecular weight:
- 42868.5
Reactions
sn-glycerol 3-phosphate + NAD(+) → glycerone phosphate + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the production of glycerol under anaerobic growth conditions. Glycerol production serves as a redox sink by consuming the excess cytosolic NADH during anaerobic metabolism
- Gene Name:
- GPD2
- Uniprot ID:
- P41911
- Molecular weight:
- 49421.30078
Reactions
sn-glycerol 3-phosphate + NAD(+) → glycerone phosphate + NADH. |
- General function:
- Involved in electron carrier activity
- Specific function:
- Could be a fumarate reductase
- Gene Name:
- Not Available
- Uniprot ID:
- P32614
- Molecular weight:
- 50843.69922
Reactions
Succinate + NAD(+) → fumarate + NADH. |
- General function:
- Involved in FMN reductase activity
- Specific function:
- Has several reductase activities that are NAD(P)H- dependent and involve FMN as a cofactor, ferricyanide being the best substrate for reduction. May be involved in ferric iron assimilation
- Gene Name:
- LOT6
- Uniprot ID:
- Q07923
- Molecular weight:
- 21280.40039
Reactions
FMNH(2) + NAD(P)(+) → FMN + NAD(P)H. |
- General function:
- Involved in zinc ion binding
- Specific function:
- L-iditol + NAD(+) = L-sorbose + NADH
- Gene Name:
- SOR1
- Uniprot ID:
- P35497
- Molecular weight:
- 38165.39844
Reactions
L-iditol + NAD(+) → L-sorbose + NADH. |
- General function:
- Involved in zinc ion binding
- Specific function:
- L-iditol + NAD(+) = L-sorbose + NADH
- Gene Name:
- SOR2
- Uniprot ID:
- Q07786
- Molecular weight:
- 38096.30078
Reactions
L-iditol + NAD(+) → L-sorbose + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE1, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxydation
- Gene Name:
- NDE2
- Uniprot ID:
- Q07500
- Molecular weight:
- 61658.69922
Reactions
NADH + ubiquinone → NAD(+) + ubiquinol. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- External NADH dehydrogenase required for optimum cellular growth with a number of nonfermentable carbon sources, including ethanol. With NDE2, performes the mitochondrial oxidation of cytosolic NADH under these growth conditions. Regulates the mitochondrial glycerol-3-phosphate dehydrogenase, GUT2, also involved in cytosolic NADH oxydation
- Gene Name:
- NDE1
- Uniprot ID:
- P40215
- Molecular weight:
- 62773.60156
Reactions
NADH + ubiquinone → NAD(+) + ubiquinol. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the oxidation of NADH generated inside the Mitochondrion
- Gene Name:
- NDI1
- Uniprot ID:
- P32340
- Molecular weight:
- 57249.30078
Reactions
NADH + ubiquinone → NAD(+) + ubiquinol. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- L-glutamate + H(2)O + NAD(+) = 2-oxoglutarate + NH(3) + NADH
- Gene Name:
- GDH2
- Uniprot ID:
- P33327
- Molecular weight:
- 124331.0
Reactions
L-glutamate + H(2)O + NAD(+) → 2-oxoglutarate + NH(3) + NADH. |
- General function:
- Involved in hydrolase activity
- Specific function:
- NAD(+) + H(2)O = AMP + NMN
- Gene Name:
- NPY1
- Uniprot ID:
- P53164
- Molecular weight:
- 43516.0
Reactions
NAD(+) + H(2)O → AMP + NMN. |
- General function:
- Involved in ligase activity
- Specific function:
- Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha- aminoadipate by NADPH
- Gene Name:
- LYS2
- Uniprot ID:
- P07702
- Molecular weight:
- 155344.0
Reactions
L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O → L-2-aminoadipate + NAD(P)H. |
- General function:
- Involved in monooxygenase activity
- Specific function:
- Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid
- Gene Name:
- BNA4
- Uniprot ID:
- P38169
- Molecular weight:
- 52428.89844
Reactions
L-kynurenine + NADPH + O(2) → 3-hydroxy-L-kynurenine + NADP(+) + H(2)O. |
- General function:
- Involved in nucleotidyltransferase activity
- Specific function:
- ATP + nicotinamide ribonucleotide = diphosphate + NAD(+);ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+
- Gene Name:
- NMA2
- Uniprot ID:
- P53204
- Molecular weight:
- 44908.69922
Reactions
ATP + nicotinamide ribonucleotide → diphosphate + NAD(+). |
ATP + nicotinate ribonucleotide → diphosphate + deamido-NAD+ |
- General function:
- Involved in nucleotidyltransferase activity
- Specific function:
- ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)
- Gene Name:
- NMA1
- Uniprot ID:
- Q06178
- Molecular weight:
- 45858.60156
Reactions
ATP + nicotinamide ribonucleotide → diphosphate + NAD(+). |
- General function:
- Involved in NAD+ kinase activity
- Specific function:
- Specifically phosphorylates NAD in the presence of ATP, dATP, or CTP as phosphoryl donors
- Gene Name:
- UTR1
- Uniprot ID:
- P21373
- Molecular weight:
- 59468.69922
Reactions
ATP + NAD(+) → ADP + NADP(+). |
- General function:
- Involved in NAD+ kinase activity
- Specific function:
- Phosphorylates both NADH and NAD(+), with a twofold preference for NADH. Anti-oxidant factor and key source of the cellular reductant NADPH
- Gene Name:
- POS5
- Uniprot ID:
- Q06892
- Molecular weight:
- 46246.5
Reactions
ATP + NADH → ADP + NADPH. |
- General function:
- Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- Specific function:
- The isoenzyme MDH2 may function primarily in the glyoxylate cycle
- Gene Name:
- MDH2
- Uniprot ID:
- P22133
- Molecular weight:
- 40730.39844
Reactions
(S)-malate + NAD(+) → oxaloacetate + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- (S)-malate + NAD(+) = pyruvate + CO(2) + NADH
- Gene Name:
- MAE1
- Uniprot ID:
- P36013
- Molecular weight:
- 74375.29688
Reactions
(S)-malate + NAD(+) → pyruvate + CO(2) + NADH. |
- General function:
- Involved in zinc ion binding
- Specific function:
- Xylitol + NAD(+) = D-xylulose + NADH
- Gene Name:
- XYL2
- Uniprot ID:
- Q07993
- Molecular weight:
- 38600.10156
Reactions
Xylitol + NAD(+) → D-xylulose + NADH. |
- General function:
- Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
- Specific function:
- D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
- Gene Name:
- TDH1
- Uniprot ID:
- P00360
- Molecular weight:
- 35749.60156
Reactions
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) → 3-phospho-D-glyceroyl phosphate + NADH. |
- General function:
- Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
- Specific function:
- D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
- Gene Name:
- TDH2
- Uniprot ID:
- P00358
- Molecular weight:
- 35846.60156
Reactions
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) → 3-phospho-D-glyceroyl phosphate + NADH. |
- General function:
- Involved in binding
- Specific function:
- Catalyzes oxidation of cytoplasmic one-carbon units for purine biosynthesis
- Gene Name:
- MTD1
- Uniprot ID:
- Q02046
- Molecular weight:
- 36239.30078
Reactions
5,10-methylenetetrahydrofolate + NAD(+) → 5,10-methenyltetrahydrofolate + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- An aldehyde + NAD(+) + H(2)O = an acid + NADH
- Gene Name:
- ALD1
- Uniprot ID:
- P22281
- Molecular weight:
- 59506.80078
Reactions
An aldehyde + NAD(+) + H(2)O → an acid + NADH. |
- General function:
- Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
- Specific function:
- D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
- Gene Name:
- TDH3
- Uniprot ID:
- P00359
- Molecular weight:
- 35746.39844
Reactions
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) → 3-phospho-D-glyceroyl phosphate + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- The outer membrane form may mediate the reduction of outer membrane cytochrome b5, and the soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria. Involved in the reduction of D-erythroascorbyl free radicals
- Gene Name:
- MCR1
- Uniprot ID:
- P36060
- Molecular weight:
- 34137.69922
Reactions
NADH + 2 ferricytochrome b5 → NAD(+) + H(+) + 2 ferrocytochrome b5. |
- General function:
- Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- Specific function:
- Formate + NAD(+) = CO(2) + NADH
- Gene Name:
- FDH1
- Uniprot ID:
- Q08911
- Molecular weight:
- 41714.0
Reactions
Formate + NAD(+) → CO(2) + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- 1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5- phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4-carboxamide
- Gene Name:
- HIS4
- Uniprot ID:
- P00815
- Molecular weight:
- 87720.5
Reactions
1-(5-phosphoribosyl)-AMP + H(2)O → 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. |
1-(5-phosphoribosyl)-ATP + H(2)O → 1-(5-phosphoribosyl)-AMP + diphosphate. |
L-histidinol + H(2)O + 2 NAD(+) → L-histidine + 2 NADH. |
- General function:
- Involved in zinc ion binding
- Specific function:
- Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH (Potential)
- Gene Name:
- BDH2
- Uniprot ID:
- P39713
- Molecular weight:
- 46098.19922
Reactions
(R)-acetoin + NAD(+) → diacetyl + NADH. |
- General function:
- Involved in transferase activity, transferring phosphorus-containing groups
- Specific function:
- Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate
- Gene Name:
- TPT1
- Uniprot ID:
- Q12272
- Molecular weight:
- 26196.19922
Reactions
2'-phospho-[ligated tRNA] + NAD(+) → mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H(2)O. |
- General function:
- Involved in zinc ion binding
- Specific function:
- Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH
- Gene Name:
- BDH1
- Uniprot ID:
- P39714
- Molecular weight:
- 41537.69922
Reactions
(R)-acetoin + NAD(+) → diacetyl + NADH. |
- General function:
- Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- Specific function:
- (S)-malate + NAD(+) = oxaloacetate + NADH
- Gene Name:
- MDH3
- Uniprot ID:
- P32419
- Molecular weight:
- 37185.89844
Reactions
(S)-malate + NAD(+) → oxaloacetate + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase- epimerase activities. Converts trans-2-enoyl-CoA via D-3- hydroxyacyl-CoA to 3-ketoacyl-CoA
- Gene Name:
- FOX2
- Uniprot ID:
- Q02207
- Molecular weight:
- 98702.39844
Reactions
(3R)-3-hydroxyacyl-CoA → (2E)-2-enoyl-CoA + H(2)O. |
(R)-3-hydroxyacyl-CoA + NAD(+) → 3-oxoacyl-CoA + NADH. |
- General function:
- Involved in iron ion binding
- Specific function:
- Required for the uptake of Fe(3+) ions. May participate in the transport of electrons from cytoplasm to an extracellular substrate (Fe(3+) ion) via FAD and heme intermediates. Involved in iron homeostasis
- Gene Name:
- FRE8
- Uniprot ID:
- Q12209
- Molecular weight:
- 78947.70313
Reactions
2 Fe(2+) + NAD(+) → 2 Fe(3+) + NADH. |
- General function:
- Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- Specific function:
- Formate + NAD(+) = CO(2) + NADH
- Gene Name:
- FDH2
- Uniprot ID:
- P0CF35
- Molecular weight:
- 26487.19922
Reactions
Formate + NAD(+) → CO(2) + NADH. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate
- Gene Name:
- LYS12
- Uniprot ID:
- P40495
- Molecular weight:
- 40068.60156
Reactions
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD(+) → 2-oxoadipate + CO(2) + NADH. |
- General function:
- Involved in binding
- Specific function:
- Catalyzes the conversion of precorrin-2 into siroheme. This reaction consist of the NAD-dependent oxidation of precorrin- 2 into sirohydrochlorin and its subsequent ferrochelation into siroheme
- Gene Name:
- MET8
- Uniprot ID:
- P15807
- Molecular weight:
- 31917.40039
Reactions
Precorrin-2 + NAD(+) → sirohydrochlorin + NADH. |
Siroheme + 2 H(+) → sirohydrochlorin + Fe(2+). |
- General function:
- Involved in catalytic activity
- Specific function:
- Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
- Gene Name:
- IMD4
- Uniprot ID:
- P50094
- Molecular weight:
- 56393.5
Reactions
Inosine 5'-phosphate + NAD(+) + H(2)O → xanthosine 5'-phosphate + NADH. |
- General function:
- Involved in catalytic activity
- Specific function:
- Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
- Gene Name:
- IMD3
- Uniprot ID:
- P50095
- Molecular weight:
- 56584.39844
Reactions
Inosine 5'-phosphate + NAD(+) + H(2)O → xanthosine 5'-phosphate + NADH. |
- General function:
- Involved in catalytic activity
- Specific function:
- Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
- Gene Name:
- IMD2
- Uniprot ID:
- P38697
- Molecular weight:
- 56529.5
Reactions
Inosine 5'-phosphate + NAD(+) + H(2)O → xanthosine 5'-phosphate + NADH. |
- General function:
- Involved in catalytic activity
- Specific function:
- Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
- Gene Name:
- IMD1
- Uniprot ID:
- P39567
- Molecular weight:
- 44385.80078
Reactions
Inosine 5'-phosphate + NAD(+) + H(2)O → xanthosine 5'-phosphate + NADH. |
- General function:
- Involved in magnesium ion binding
- Specific function:
- Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate
- Gene Name:
- LEU2
- Uniprot ID:
- P04173
- Molecular weight:
- 38952.5
Reactions
(2R,3S)-3-isopropylmalate + NAD(+) → 4-methyl-2-oxopentanoate + CO(2) + NADH. |
- General function:
- Involved in zinc ion binding
- Specific function:
- NADP-dependent alcohol dehydrogenase with a broad substrate specificity
- Gene Name:
- ADH7
- Uniprot ID:
- P25377
- Molecular weight:
- 39348.19922
Reactions
An alcohol + NADP(+) → an aldehyde + NADPH. |
- General function:
- Involved in zinc ion binding
- Specific function:
- NADP-dependent alcohol dehydrogenase with a broad substrate specificity
- Gene Name:
- ADH6
- Uniprot ID:
- Q04894
- Molecular weight:
- 39617.30078
Reactions
An alcohol + NADP(+) → an aldehyde + NADPH. |
- General function:
- Involved in protein complex assembly
- Specific function:
- Required for the assembly of yeast cytochrome oxidase. Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin and ferredoxin reductase
- Gene Name:
- COX15
- Uniprot ID:
- P40086
- Molecular weight:
- 54657.89844
- General function:
- Involved in oxidoreductase activity
- Specific function:
- (S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H
- Gene Name:
- PUT2
- Uniprot ID:
- P07275
- Molecular weight:
- 64434.60156
Reactions
(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O → L-glutamate + NAD(P)H. |
- General function:
- Involved in proline dehydrogenase activity
- Specific function:
- Converts proline to delta-1-pyrroline-5-carboxylate
- Gene Name:
- PUT1
- Uniprot ID:
- P09368
- Molecular weight:
- 53270.89844
Reactions
L-proline + acceptor → (S)-1-pyrroline-5-carboxylate + reduced acceptor. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway
- Gene Name:
- ERG1
- Uniprot ID:
- P32476
- Molecular weight:
- 55125.39844
Reactions
Squalene + AH(2) + O(2) → (S)-squalene-2,3-epoxide + A + H(2)O. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- L-proline + NAD(P)(+) = 1-pyrroline-5- carboxylate + NAD(P)H
- Gene Name:
- PRO3
- Uniprot ID:
- P32263
- Molecular weight:
- 30131.59961
Reactions
L-proline + NAD(P)(+) → 1-pyrroline-5-carboxylate + NAD(P)H. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate
- Gene Name:
- PRO2
- Uniprot ID:
- P54885
- Molecular weight:
- 49740.0
Reactions
L-glutamate 5-semialdehyde + phosphate + NADP(+) → L-glutamyl 5-phosphate + NADPH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Not Available
- Gene Name:
- DSF1
- Uniprot ID:
- P39941
- Molecular weight:
- 56469.69922
Reactions
D-mannitol + NAD+ → D-fructose + NADH + H+ |
- General function:
- Involved in ubiquinone biosynthetic process
- Specific function:
- Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides
- Gene Name:
- COQ4
- Uniprot ID:
- O13525
- Molecular weight:
- 38626.80078
- General function:
- Involved in 3-beta-hydroxy-delta5-steroid dehydrogenase activity
- Specific function:
- 3-beta-hydroxy-4-beta-methyl-5-alpha-cholest- 7-ene-4-alpha-carboxylate + NAD(P)(+) = 4-alpha-methyl-5-alpha- cholest-7-en-3-one + CO(2) + NAD(P)H
- Gene Name:
- ERG26
- Uniprot ID:
- P53199
- Molecular weight:
- 38706.10156
Reactions
3-beta-hydroxy-4-beta-methyl-5-alpha-cholest-7-ene-4-alpha-carboxylate + NAD(P)(+) → 4-alpha-methyl-5-alpha-cholest-7-en-3-one + CO(2) + NAD(P)H. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Prephenate + NADP(+) = 4-hydroxyphenylpyruvate + CO(2) + NADPH
- Gene Name:
- TYR1
- Uniprot ID:
- P20049
- Molecular weight:
- 50922.89844
Reactions
Prephenate + NADP(+) → 4-hydroxyphenylpyruvate + CO(2) + NADPH. |
- General function:
- Involved in 5-amino-6-(5-phosphoribosylamino)uracil reductase activity
- Specific function:
- 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NADPH
- Gene Name:
- RIB7
- Uniprot ID:
- P33312
- Molecular weight:
- 27116.0
Reactions
5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) → 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH. |
- General function:
- Involved in oxoglutarate dehydrogenase (succinyl-transferring) activity
- Specific function:
- The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)
- Gene Name:
- KGD1
- Uniprot ID:
- P20967
- Molecular weight:
- 114416.0
Reactions
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine → [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2). |
- General function:
- Involved in catalytic activity
- Specific function:
- The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
- Gene Name:
- PDB1
- Uniprot ID:
- P32473
- Molecular weight:
- 40053.19922
Reactions
Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine → [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2). |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS)
- Gene Name:
- TSC10
- Uniprot ID:
- P38342
- Molecular weight:
- 35986.19922
Reactions
Sphinganine + NADP(+) → 3-dehydrosphinganine + NADPH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H
- Gene Name:
- HOM6
- Uniprot ID:
- P31116
- Molecular weight:
- 38501.69922
Reactions
L-homoserine + NAD(P)(+) → L-aspartate 4-semialdehyde + NAD(P)H. |
- General function:
- Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- Specific function:
- 3-phospho-D-glycerate + NAD(+) = 3- phosphonooxypyruvate + NADH
- Gene Name:
- SER3
- Uniprot ID:
- P40054
- Molecular weight:
- 51192.80078
Reactions
3-phospho-D-glycerate + NAD(+) → 3-phosphonooxypyruvate + NADH. |
2-hydroxyglutarate + NAD(+) → 2-oxoglutarate + NADH. |
- General function:
- Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- Specific function:
- (S)-malate + NAD(+) = oxaloacetate + NADH
- Gene Name:
- MDH1
- Uniprot ID:
- P17505
- Molecular weight:
- 35649.60156
Reactions
(S)-malate + NAD(+) → oxaloacetate + NADH. |
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes. Plays a role in bud morphology
- Gene Name:
- CBR1
- Uniprot ID:
- P38626
- Molecular weight:
- 31493.59961
Reactions
NADH + 2 ferricytochrome b5 → NAD(+) + H(+) + 2 ferrocytochrome b5. |
Transporters
- General function:
- Involved in binding
- Specific function:
- Not Available
- Gene Name:
- Not Available
- Uniprot ID:
- P40556
- Molecular weight:
- 41954.0