NADP (YMDB00427)

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the oxidation of D-arabinose, L-xylose, L- fucose and L-galactose in the presence of NADP+

Gene Name:

ARA1

Uniprot ID:

P38115

Molecular weight:

38883.19922

Reactions

General function:

Involved in iron ion binding

Specific function:

Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol

Gene Name:

ERG11

Uniprot ID:

P10614

Molecular weight:

60719.80078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Unknown function which seems to be not essential

Gene Name:

GCY1

Uniprot ID:

P14065

Molecular weight:

35078.89844

Reactions

General function:

Involved in binding

Specific function:

N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NADP(+) + H(2)O = L-glutamate + L-2-aminoadipate 6-semialdehyde + NADPH

Gene Name:

LYS9

Uniprot ID:

P38999

Molecular weight:

48917.30078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(+) + H(2)O = an acid + NADH

Gene Name:

ALD4

Uniprot ID:

P46367

Molecular weight:

56723.19922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H

Gene Name:

ALD3

Uniprot ID:

P54114

Molecular weight:

55384.80078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

An aldehyde + NAD(+) + H(2)O = an acid + NADH

Gene Name:

ALD6

Uniprot ID:

P54115

Molecular weight:

54413.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Minor mitochondrial aldehyde dehydrogenase isoform. Plays a role in regulation or biosynthesis of electron transport chain components. Involved in the biosynthesis of acetate during anaerobic growth on glucose

Gene Name:

ALD5

Uniprot ID:

P40047

Molecular weight:

56620.39844

Reactions

General function:

Involved in magnesium ion binding

Specific function:

May function in the production of NADPH for fatty acid and sterol synthesis

Gene Name:

IDP3

Uniprot ID:

P53982

Molecular weight:

47856.0

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Mitochondrial IDP1 may regulate flux through the tricarboxylic acid cycle and respiration. Its probably critical function is the production of NADPH

Gene Name:

IDP1

Uniprot ID:

P21954

Molecular weight:

48189.89844

Reactions

General function:

Involved in magnesium ion binding

Specific function:

May function in the production of NADPH for fatty acid and sterol synthesis

Gene Name:

IDP2

Uniprot ID:

P41939

Molecular weight:

46561.89844

Reactions

General function:

Involved in 3-dehydroquinate dehydratase activity

Specific function:

The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis

Gene Name:

ARO1

Uniprot ID:

P08566

Molecular weight:

174754.0

Reactions

General function:

Involved in aspartate-semialdehyde dehydrogenase activity

Specific function:

This enzyme catalyzes the second step in the common metabolic pathway to synthesize Thr and Met from Asp

Gene Name:

HOM2

Uniprot ID:

P13663

Molecular weight:

39543.30078

Reactions

General function:

Involved in binding

Specific function:

Responsible for the reduction of the keto group on the C-3 of sterols. Also facilitates the association of ERG7 with lipid particles preventing its digestion in the endoplasmic reticulum and the lipid particles

Gene Name:

ERG27

Uniprot ID:

Q12452

Molecular weight:

39724.39844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+)

Gene Name:

Not Available

Uniprot ID:

Q06494

Molecular weight:

38600.39844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

(R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH

Gene Name:

ILV5

Uniprot ID:

P06168

Molecular weight:

44368.10156

Reactions

General function:

Involved in fatty acid elongase activity

Specific function:

Involved in synthesis of 1,3-beta-glucan. Could be a subunit of 1,3-beta-glucan synthase. Could be also a component of the membrane bound fatty acid elongation systems that produce the 26-carbon very long chain fatty acids that are precursors for ceramide and sphingolipids. Appears to be involved in the elongation of fatty acids up to 24 carbons. Appears to have the highest affinity for substrates with chain length less than 22 carbons

Gene Name:

FEN1

Uniprot ID:

P25358

Molecular weight:

40001.80078

Reactions

General function:

Involved in hydroxymethylglutaryl-CoA reductase (NADPH) activity

Specific function:

This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of the sterol biosynthesis

Gene Name:

HMG1

Uniprot ID:

P12683

Molecular weight:

115624.0

Reactions

General function:

Involved in hydroxymethylglutaryl-CoA reductase (NADPH) activity

Specific function:

This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of the sterol biosynthesis

Gene Name:

HMG2

Uniprot ID:

P12684

Molecular weight:

115691.0

Reactions

General function:

Involved in acyl-CoA dehydrogenase activity

Specific function:

Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2)

Gene Name:

POX1

Uniprot ID:

P13711

Molecular weight:

84041.39844

Reactions

General function:

Involved in fatty acid elongase activity

Specific function:

May be a membrane bound enzyme involved in the highly specific elongation of saturated 14-carbon fatty acids (14:0) to 16-carbon species (16:0)

Gene Name:

ELO1

Uniprot ID:

P39540

Molecular weight:

36233.60156

Reactions

General function:

Involved in acyl carrier activity

Specific function:

Carrier of the growing fatty acid chain in fatty acid biosynthesis. May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Gene Name:

ACP1

Uniprot ID:

P32463

Molecular weight:

13942.5

General function:

Involved in transferase activity

Specific function:

Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for:[acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase

Gene Name:

FAS1

Uniprot ID:

P07149

Molecular weight:

228689.0

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for:acyl carrier protein, 3- oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl- carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex

Gene Name:

FAS2

Uniprot ID:

P19097

Molecular weight:

206945.0

Reactions

General function:

Involved in acetylglutamate kinase activity

Specific function:

N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH

Gene Name:

ARG5

Uniprot ID:

Q01217

Molecular weight:

94868.39844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Maintains high levels of reduced glutathione in the cytosol

Gene Name:

GLR1

Uniprot ID:

P41921

Molecular weight:

53440.60156

Reactions

General function:

Involved in dihydrofolate reductase activity

Specific function:

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis

Gene Name:

DFR1

Uniprot ID:

P07807

Molecular weight:

24260.80078

Reactions

General function:

Involved in formate-tetrahydrofolate ligase activity

Specific function:

5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH

Gene Name:

MIS1

Uniprot ID:

P09440

Molecular weight:

106216.0

Reactions

General function:

Involved in formate-tetrahydrofolate ligase activity

Specific function:

5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH

Gene Name:

ADE3

Uniprot ID:

P07245

Molecular weight:

102204.0

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

Gene Name:

HEM13

Uniprot ID:

P11353

Molecular weight:

37711.30078

Reactions

General function:

Involved in FMN reductase activity

Specific function:

Has several reductase activities that are NAD(P)H- dependent and involve FMN as a cofactor, ferricyanide being the best substrate for reduction. May be involved in ferric iron assimilation

Gene Name:

LOT6

Uniprot ID:

Q07923

Molecular weight:

21280.40039

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH

Gene Name:

GDH3

Uniprot ID:

P39708

Molecular weight:

49626.80078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH

Gene Name:

GDH1

Uniprot ID:

P07262

Molecular weight:

49569.60156

Reactions

General function:

Involved in ligase activity

Specific function:

Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha- aminoadipate by NADPH

Gene Name:

LYS2

Uniprot ID:

P07702

Molecular weight:

155344.0

Reactions

General function:

Involved in monooxygenase activity

Specific function:

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid

Gene Name:

BNA4

Uniprot ID:

P38169

Molecular weight:

52428.89844

Reactions

General function:

Involved in NAD+ kinase activity

Specific function:

Specifically phosphorylates NAD in the presence of ATP, dATP, or CTP as phosphoryl donors

Gene Name:

UTR1

Uniprot ID:

P21373

Molecular weight:

59468.69922

Reactions

General function:

Involved in amino acid binding

Specific function:

ATP + L-aspartate = ADP + 4-phospho-L- aspartate

Gene Name:

HOM3

Uniprot ID:

P10869

Molecular weight:

58109.19922

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the irreversible reduction of the cytotoxic compound methylglyoxal (MG) to (R)-lactaldehyde as an alternative to detoxification of MG by glyoxalase I GLO1. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation

Gene Name:

GRE2

Uniprot ID:

Q12068

Molecular weight:

38169.19922

Reactions

General function:

Involved in NAD+ kinase activity

Specific function:

Phosphorylates both NADH and NAD(+), with a twofold preference for NADH. Anti-oxidant factor and key source of the cellular reductant NADPH

Gene Name:

POS5

Uniprot ID:

Q06892

Molecular weight:

46246.5

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

(S)-malate + NAD(+) = pyruvate + CO(2) + NADH

Gene Name:

MAE1

Uniprot ID:

P36013

Molecular weight:

74375.29688

Reactions

General function:

Involved in binding

Specific function:

Catalyzes the conversion of precorrin-2 into siroheme. This reaction consist of the NAD-dependent oxidation of precorrin- 2 into sirohydrochlorin and its subsequent ferrochelation into siroheme

Gene Name:

MET8

Uniprot ID:

P15807

Molecular weight:

31917.40039

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Reduces the cytotoxic compound methylglyoxal (MG) to (R)-lactaldehyde similar to GRE2. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation. In pentose-fermenting yeasts, aldose reductase catalyzes the reduction of xylose into xylitol. The purified enzyme catalyzes this reaction, but the inability of S.cerevisiae to grow on xylose as sole carbon source indicates that the physiological function is more likely methylglyoxal reduction

Gene Name:

GRE3

Uniprot ID:

P38715

Molecular weight:

37118.5

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q05016

Molecular weight:

29158.09961

Reactions

General function:

Involved in iron ion binding

Specific function:

Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate

Gene Name:

ECM17

Uniprot ID:

P47169

Molecular weight:

161218.0

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate

Gene Name:

MET10

Uniprot ID:

P39692

Molecular weight:

114827.0

Reactions

General function:

Involved in zinc ion binding

Specific function:

NADP-dependent alcohol dehydrogenase with a broad substrate specificity

Gene Name:

ADH7

Uniprot ID:

P25377

Molecular weight:

39348.19922

Reactions

General function:

Involved in enzyme regulator activity

Specific function:

Required for calcium regulation. May regulate calcium accumulation by a non-vacuole organelle. Also regulates the activity of CSH1 and SUR1 during mannosyl phosphorylinositol ceramide synthesis

Gene Name:

CSG2

Uniprot ID:

P35206

Molecular weight:

45441.60156

Reactions

General function:

Involved in zinc ion binding

Specific function:

NADP-dependent alcohol dehydrogenase with a broad substrate specificity

Gene Name:

ADH6

Uniprot ID:

Q04894

Molecular weight:

39617.30078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Reduces benzil stereospecifically to (S)-benzoin. Is probably involved in a pathway contributing to genomic integrity

Gene Name:

IRC24

Uniprot ID:

P40580

Molecular weight:

28803.90039

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H

Gene Name:

PUT2

Uniprot ID:

P07275

Molecular weight:

64434.60156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway

Gene Name:

ERG1

Uniprot ID:

P32476

Molecular weight:

55125.39844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

L-proline + NAD(P)(+) = 1-pyrroline-5- carboxylate + NAD(P)H

Gene Name:

PRO3

Uniprot ID:

P32263

Molecular weight:

30131.59961

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

Gene Name:

PRO2

Uniprot ID:

P54885

Molecular weight:

49740.0

Reactions

General function:

Involved in 3-beta-hydroxy-delta5-steroid dehydrogenase activity

Specific function:

3-beta-hydroxy-4-beta-methyl-5-alpha-cholest- 7-ene-4-alpha-carboxylate + NAD(P)(+) = 4-alpha-methyl-5-alpha- cholest-7-en-3-one + CO(2) + NAD(P)H

Gene Name:

ERG26

Uniprot ID:

P53199

Molecular weight:

38706.10156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Prephenate + NADP(+) = 4-hydroxyphenylpyruvate + CO(2) + NADPH

Gene Name:

TYR1

Uniprot ID:

P20049

Molecular weight:

50922.89844

Reactions

General function:

Involved in 5-amino-6-(5-phosphoribosylamino)uracil reductase activity

Specific function:

5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NADPH

Gene Name:

RIB7

Uniprot ID:

P33312

Molecular weight:

27116.0

Reactions

General function:

Involved in zinc ion binding

Specific function:

NADPH + 2 quinone = NADP(+) + 2 semiquinone

Gene Name:

ZTA1

Uniprot ID:

P38230

Molecular weight:

37018.30078

Reactions

General function:

Involved in electron carrier activity

Specific function:

Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage

Gene Name:

GRX2

Uniprot ID:

P17695

Molecular weight:

15861.2998

Reactions

General function:

Involved in electron carrier activity

Specific function:

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (Probable)

Gene Name:

GRX4

Uniprot ID:

P32642

Molecular weight:

27492.59961

General function:

Involved in electron carrier activity

Specific function:

Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage

Gene Name:

GRX1

Uniprot ID:

P25373

Molecular weight:

12380.09961

Reactions

General function:

Involved in iron ion binding

Specific function:

Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol

Gene Name:

ERG25

Uniprot ID:

P53045

Molecular weight:

36478.89844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS)

Gene Name:

TSC10

Uniprot ID:

P38342

Molecular weight:

35986.19922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively. Required for the biosynthesis of phosphatidic acid via the DHAP pathway, where it reduces 1-acyl DHAP to lysophosphatidic acid (LPA). Required for spore germination

Gene Name:

AYR1

Uniprot ID:

P40471

Molecular weight:

32813.60156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake

Gene Name:

FRE1

Uniprot ID:

P32791

Molecular weight:

78853.0

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to dihydroxamate rhodotorulic acid. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane

Gene Name:

FRE4

Uniprot ID:

P53746

Molecular weight:

82014.60156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Siderophore-iron reductase responsible for reducing extracellular iron prior to import. Catalyzes the reductive uptake of Fe(3+) bound to di- and trihydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane

Gene Name:

FRE3

Uniprot ID:

Q08905

Molecular weight:

80588.5

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Cell surface metalloreductase

Gene Name:

FRE5

Uniprot ID:

Q08908

Molecular weight:

80291.70313

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Metalloreductase responsible for reducing vacuolar iron and copper prior to transport into the cytosol. Catalyzes the reduction of Fe(3+) to Fe(2+) and Cu(2+) to Cu(+), respectively, which can then be transported by the respective vacuolar efflux systems to the cytosol

Gene Name:

FRE6

Uniprot ID:

Q12473

Molecular weight:

81988.29688

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Metalloreductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake

Gene Name:

FRE2

Uniprot ID:

P36033

Molecular weight:

80071.5

Reactions

General function:

Involved in electron carrier activity

Specific function:

Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl- hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER- derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism. Through its capacity to inactivate the stress response transcription factor YAP1 and its regulator the hydroperoxide stress sensor HYR1, it is involved in feedback regulation of stress response gene expression upon oxidative stress

Gene Name:

TRX2

Uniprot ID:

P22803

Molecular weight:

11203.7998

Reactions

General function:

Involved in electron carrier activity

Specific function:

Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl- hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER- derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism

Gene Name:

TRX1

Uniprot ID:

P22217

Molecular weight:

11234.90039

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

Gene Name:

GND1

Uniprot ID:

P38720

Molecular weight:

53542.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

Gene Name:

GND2

Uniprot ID:

P53319

Molecular weight:

53922.30078

Reactions

General function:

Involved in transferase activity

Specific function:

May regulate the flux of isoprene intermediates through the sterol pathway. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. ERG9 is also essential for cell growth in yeast

Gene Name:

ERG9

Uniprot ID:

P29704

Molecular weight:

51719.39844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H

Gene Name:

UGA2

Uniprot ID:

P38067

Molecular weight:

54188.80078

Reactions

General function:

Involved in delta14-sterol reductase activity

Specific function:

Reduces the C14=C15 double bond of 4,4-dimethyl- cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24- dienol

Gene Name:

ERG24

Uniprot ID:

P32462

Molecular weight:

50615.0

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Not Available

Gene Name:

YPR1

Uniprot ID:

Q12458

Molecular weight:

34754.69922

Reactions

General function:

Involved in iron ion binding

Specific function:

Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Involved in the response to syringomycin

Gene Name:

SUR2

Uniprot ID:

P38992

Molecular weight:

40734.0

Reactions

General function:

Involved in zinc ion binding

Specific function:

Required for respiration and the maintenance of the mitochondrial compartment. May have a role in the mitochondrial synthesis of fatty acids

Gene Name:

ETR1

Uniprot ID:

P38071

Molecular weight:

42066.5

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

2 reduced ferredoxin + NADP(+) + H(+) = 2 oxidized ferredoxin + NADPH

Gene Name:

ARH1

Uniprot ID:

P48360

Molecular weight:

56236.69922

Reactions

General function:

Involved in oxidoreductase activity, acting on the CH-CH group of donors

Specific function:

Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long chain fatty acids (VLCFA) from palmitate. Catalyzes the last step in each elongation cycle that lengthens palmitate by two carbon units. VLCFAs serve as precursors for ceramide and sphingolipids. Required for normal biogenesis of piecemeal microautophagy of the nucleus (PMN) bleps and vesicles during nutrient stress

Gene Name:

TSC13

Uniprot ID:

Q99190

Molecular weight:

36767.5

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Involved in biosynthesis of fatty acids in mitochondria

Gene Name:

OAR1

Uniprot ID:

P35731

Molecular weight:

31183.69922

Reactions

General function:

Involved in catalytic activity

Specific function:

Oxidizes beta-NADH, beta-NADPH, and alpha-NADPH

Gene Name:

OYE2

Uniprot ID:

Q03558

Molecular weight:

45010.39844

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Dispensable for growth and sporulation on solid acetate and oleate media, but is essential for these processes to occur on petroselineate

Gene Name:

SPS19

Uniprot ID:

P32573

Molecular weight:

31108.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids

Gene Name:

IFA38

Uniprot ID:

P38286

Molecular weight:

38707.80078

Reactions

General function:

Involved in catalytic activity

Specific function:

Oxidizes beta-NADH, beta-NADPH, and alpha-NADPH

Gene Name:

OYE3

Uniprot ID:

P41816

Molecular weight:

44920.10156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5

Gene Name:

NCP1

Uniprot ID:

P16603

Molecular weight:

76771.10156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Acts on thioredoxins 1 and 2

Gene Name:

TRR1

Uniprot ID:

P29509

Molecular weight:

34237.80078

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Acts on mitochondrial thioredoxin 3. Implicated in the defense against oxidative stress

Gene Name:

TRR2

Uniprot ID:

P38816

Molecular weight:

37087.0

Reactions

General function:

Involved in delta24(24-1) sterol reductase activity

Specific function:

Ergosterol + NADP(+) = ergosta- 5,7,22,24(24(1))-tetraen-3-beta-ol + NADPH

Gene Name:

ERG4

Uniprot ID:

P25340

Molecular weight:

56039.30078

Reactions

General function:

Involved in stearoyl-CoA 9-desaturase activity

Specific function:

Utilizes O(2) and electrons from the reduced cytochrome b(5) domain to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates (Probable)

Gene Name:

OLE1

Uniprot ID:

P21147

Molecular weight:

58402.60156

Reactions

General function:

Involved in heme binding

Specific function:

Ceramide hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Hydroxylates the very long chain fatty acid of ceramides at C2 and C3

Gene Name:

SCS7

Uniprot ID:

Q03529

Molecular weight:

44881.10156

Reactions

General function:

Involved in iron ion binding

Specific function:

Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis

Gene Name:

ERG3

Uniprot ID:

P32353

Molecular weight:

42729.89844

Reactions

General function:

Involved in electron carrier activity

Specific function:

Not Available

Gene Name:

TRX3

Uniprot ID:

P25372

Molecular weight:

14432.0

General function:

Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

P53839

Molecular weight:

38831.19922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H

Gene Name:

HOM6

Uniprot ID:

P31116

Molecular weight:

38501.69922

Reactions

General function:

Involved in glucose-6-phosphate dehydrogenase activity

Specific function:

D-glucose 6-phosphate + NADP(+) = D-glucono- 1,5-lactone 6-phosphate + NADPH

Gene Name:

ZWF1

Uniprot ID:

P11412

Molecular weight:

57521.10156

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid

Gene Name:

PAN5

Uniprot ID:

P38787

Molecular weight:

42820.89844

Reactions

General function:

Involved in methylenetetrahydrofolate reductase (NADPH) activity

Specific function:

5-methyltetrahydrofolate + NAD(P)(+) = 5,10- methylenetetrahydrofolate + NAD(P)H

Gene Name:

MET13

Uniprot ID:

P53128

Molecular weight:

68559.5

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Cell surface metalloreductase. May be involved in copper homeostasis

Gene Name:

FRE7

Uniprot ID:

Q12333

Molecular weight:

70904.70313

Reactions