Selenocompound metabolism

Source	ID	Pathway
PathWhiz	PW002472
KEGG	00450

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00033	Glyoxylic acid 298-12-4	2-oxoacetic acid	C₂H₂O₃ 74.0355
YMDB00056	Acetic acid 64-19-7	acetic acid	C₂H₄O₂ 60.052
YMDB00071	2-Ketobutyric acid 600-18-0	2-oxobutanoic acid	C₄H₆O₃ 102.0886
YMDB00081	Tetrahydropteroyltri-L-glutamate	(2S)-2-[(4S)-4-[(4S)-4-{[4-({[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}-4-carboxybutanamido]-4-carboxybutanamido]pentanedioic acid	C₂₉H₃₇N₉O₁₂ 703.6572
YMDB00091	Ammonia 7664-41-7	ammonia	H₃N 17.0305
YMDB00097	Adenosine monophosphate 61-19-8	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid	C₁₀H₁₄N₅O₇P 347.2212
YMDB00109	Adenosine triphosphate 56-65-5	({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid	C₁₀H₁₆N₅O₁₃P₃ 507.181
YMDB00154	L-Alanine 56-41-7	(2S)-2-aminopropanoic acid	C₃H₇NO₂ 89.0932
YMDB00175	Pyruvic acid 127-17-3	2-oxopropanoic acid	C₃H₄O₃ 88.0621
YMDB00219	Pyrophosphate 14000-31-8	(phosphonooxy)phosphonic acid	H₄O₇P₂ 177.9751
YMDB00328	5-Methyltetrahydropteroyltri-L-glutamate		C₃₀H₃₉N₉O₁₂ 717.6838
YMDB00338	Succinic acid 110-15-6	butanedioic acid	C₄H₆O₄ 118.088
YMDB00426	NADPH 53-57-6	{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₁H₃₀N₇O₁₇P₃ 745.4209
YMDB00427	NADP 53-59-8	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₉N₇O₁₇P₃ 744.4129
YMDB00518	5-Methyltetrahydropteroyltri-L-glutamic acid	(2S)-2-[(4S)-4-[(4S)-4-{[4-({[(6S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}-4-carboxybutanamido]-4-carboxybutanamido]pentanedioic acid	C₃₀H₃₉N₉O₁₂ 717.6838
YMDB00862	hydron 12408-02-5	hydron	H 1.00794
YMDB00890	water 7732-18-5	water	H₂O 18.0153
YMDB00917	O-Succinyl-L-homoserine 1492-23-5	(2S)-2-amino-4-[(3-carboxypropanoyl)oxy]butanoic acid	C₈H₁₃NO₆ 219.1919
YMDB16154	Selenocysteine	(2R)-2-amino-3-selanylpropanoic acid	C₃H₇NO₂Se 168.05
YMDB16175	Selenomethionine	2-amino-4-(methylselanyl)butanoic acid	C₅H₁₁NO₂Se 196.11
YMDB16177	Se-Methylselenocysteine	(2R)-2-amino-3-(methylselanyl)propanoic acid	C₄H₉NO₂Se 182.08
YMDB16178	Selenohomocysteine	2-amino-4-selanylbutanoic acid	C₄H₉NO₂Se 182.08
YMDB16184	Selenocystathionine	2-amino-4-[(2-amino-2-carboxyethyl)selanyl]butanoic acid	C₇H₁₄N₂O₄Se 269.16
YMDB16245	Acetylhomoserine	4-(acetyloxy)-2-aminobutanoic acid	C₆H₁₁NO₄ 161.1558
YMDB16312	methylselenol	methaneselenol	CH₄Se 95.0
YMDB16313	Methylselenic acid	methaneseleninic acid	CH₄O₂Se 127.0

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P08536	MET3 YJR010W	Sulfate adenylyltransferase	Enzyme	Sulfate Adenosine triphosphate Pyrophosphate Adenosine phosphosulfate hydron
P53206	YGR012W	Putative cysteine synthase	Enzyme	L-Cysteine Acetic acid Sulfide O-acetyl-L-serine Hydrogen sulfide hydron 2-Aminoacrylic acid
Q04533	YML082W	Putative cystathionine gamma-synthase YML082W	Enzyme	L-Cysteine Acetic acid 2-Ketobutyric acid O-Acetyl-L-homoserine L-Cystathionine Succinic acid Ammonium hydron water O-Succinyl-L-homoserine
P31373	CYS3 YAL012W	Cystathionine gamma-lyase	Enzyme	L-Cysteine 2-Ketobutyric acid Ammonia Pyruvic acid L-Cystathionine Ammonium Hydrogen sulfide hydron water Selenomethionine Se-Methylselenocysteine 2-aminoprop-2-enoate methylselenol
Q12198	YLL058W	Putative cystathionine gamma-synthase YLL058W	Enzyme	L-Cysteine L-Cystathionine Succinic acid O-Succinyl-L-homoserine
P47164	STR2 YJR130C	Cystathionine gamma-synthase	Enzyme	L-Cysteine Acetic acid O-Acetyl-L-homoserine L-Cystathionine Succinic acid hydron O-Succinyl-L-homoserine Selenocysteine Selenocystathionine Acetylhomoserine
P39954	SAH1 YER043C	Adenosylhomocysteinase	Enzyme	Adenosine S-Adenosylhomocysteine Homocysteine L-Homocysteine water
P05694	MET6 YER091C	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase	Enzyme	Tetrahydropteroyltri-L-glutamate 5-Methyltetrahydrofolic acid L-Methionine 5-Methyltetrahydropteroyltri-L-glutamate Homocysteine 5,6,7,8-Tetrahydrofolic acid 5-Methyltetrahydropteroyltri-L-glutamic acid Tetrahydropteroyltri-L-glutamic acid L-Homocysteine hydron Selenomethionine Selenohomocysteine
P53101	STR3 YGL184C	Cystathionine beta-lyase	Enzyme	Ammonia Pyruvic acid L-Cystathionine Homocysteine Ammonium L-Homocysteine water Selenohomocysteine Selenocystathionine
P43623	IRC7 YFR055W	Putative cystathionine beta-lyase	Enzyme	Ammonia Pyruvic acid L-Cystathionine Homocysteine Ammonium L-Homocysteine water Selenohomocysteine Selenocystathionine
P22438	MSM1 YGR171C	Methionyl-tRNA synthetase, mitochondrial	Enzyme	Adenosine monophosphate Adenosine triphosphate Pyrophosphate L-Methionine Selenomethionine
P00958	MES1 YGR264C	Methionyl-tRNA synthetase, cytoplasmic	Enzyme	Adenosine monophosphate Adenosine triphosphate Pyrophosphate L-Methionine Selenomethionine
P10659	SAM1 YLR180W	S-adenosylmethionine synthase 1	Enzyme	Adenosine triphosphate Pyrophosphate S-Adenosylmethionine L-Methionine S-Adenosyl-L-methionine water phosphate
Q02196	MET14 YKL001C	Adenylyl-sulfate kinase	Enzyme	Adenosine triphosphate Phosphoadenosine phosphosulfate Adenosine phosphosulfate hydron ADP
P32582	CYS4 YGR155W	Cystathionine beta-synthase	Enzyme	L-Serine L-Cystathionine Homocysteine L-Homocysteine water
Q05902	ECM38 YLR299W	Gamma-glutamyltransferase	Enzyme	L-Cysteine L-Alanine Glutathione Gamma-Glutamylcysteine L-Glutamic acid L-cysteinylglycine L-gamma-Glutamyl-L-alanine water
P29509	TRR1 YDR353W	Thioredoxin reductase 1	Enzyme	NADPH NADP hydron water methylselenol Methylselenic acid
P38816	TRR2 YHR106W	Thioredoxin reductase 2, mitochondrial	Enzyme	NADPH NADP hydron water methylselenol Methylselenic acid
P19358	SAM2 YDR502C	S-adenosylmethionine synthase 2	Enzyme	Adenosine triphosphate Pyrophosphate S-Adenosylmethionine L-Methionine S-Adenosyl-L-methionine water phosphate