{"ymdb_id":"YMDB00690","created_at":"2011-05-29T18:43:43.000Z","updated_at":"2016-09-08T18:35:47.000Z","name":"L-cysteinylglycine","cas":"70-18-8","state":"Solid","melting_point":"195 oC","description":"Cysteinylglycine is a naturally occurring dipeptide. It is breakdown product of glutathione and an intermediate in the gamma-glutamyl cycle. [Biocyc PWY-4041]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":null,"chebi_id":"4047","hmdb_id":"HMDB00125","kegg_id":"C00051","pubchem_id":"65270","cs_id":"388596","foodb_id":null,"wikipedia_link":"Glutathione","biocyc_id":"OXIDIZED-GLUTATHIONE","iupac":"2-[(2R)-2-amino-3-sulfanylpropanamido]acetic acid","traditional_iupac":"Cys-Gly","logp":"-3.900224044778602","pka":"9.981290674103914","alogps_solubility":"6.25e+00 g/l","alogps_logp":"-2.59","alogps_logs":"-1.46","acceptor_count":"4","donor_count":"4","rotatable_bond_count":"4","polar_surface_area":"92.41999999999999","refractivity":"41.027100000000004","polarizability":"16.967003992118627","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"8.075279909891346","pka_strongest_acidic":"3.6045336684101867","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["5-l-glutamyl-l-cysteinylglycine","Agifutol S","Bakezyme RX","Copren","Cys-Gly","Cysteinylglycine","Deltathione","gamma-Glutamylcysteinylglycine","gamma-l-glutamyl-l-cysteinyl-glycine","gamma-L-Glutamyl-L-cysteinylglycine","Glutathion","Glutathione","Glutathione (reduced type)","Glutathione (reduced)","Glutathione red","Glutathione reduced","Glutathione-SH","Glutatiol","Glutatione","Gluthathione","Glutide","Glutinal","GSH","Isethion","L-Cysteinylglycine","L-g-glutamyl-L-cysteinyl-glycine","L-gamma-glutamyl-L-cysteinyl-glycine","L-gamma-glutamyl-L-cysteinylglycine","L-glutamyl-L-cysteinylglycine","L-Glutathione","L-Glutathione reduce","Ledac","n-(n-gamma-l-glutamyl-l-cysteinyl)glycine","N-L-cysteinylglycine","Neuthion","red. glutathione","Reduced glutathione","Tathion","Tathione","Triptide"],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-27T02:50:50.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"Gamma-glutamyltransferase","uniprot_id":"Q05902","uniprot_name":"ECM38_YEAST","enzyme":true,"transporter":false,"gene_name":"ECM38","num_residues":660,"molecular_weight":"73179.79688","theoretical_pi":"5.72","general_function":"Involved in gamma-glutamyltransferase activity","specific_function":"Plays a role in the turnover of the vacuolar glutathione and in the supply of growth requirements during nitrogen starvation","reactions":[{"id":1557,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2696,"direction":"\u003e","locations":"Vacuole membrane; Single-pass type II membrane protein","altext":"(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.","export":false,"pw_reaction_id":null,"source":null},{"id":3831,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006356","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"14-34","pdb_id":null,"cellular_location":"Vacuole membrane; Single-pass type II membrane protein","genbank_gene_id":"U17243","genbank_protein_id":"596034","gene_card_id":"ECM38","chromosome_location":"chromosome 12","locus":"YLR299W","synonyms":["CIK1 suppressor protein 2","Extracellular mutant protein 38","Gamma-glutamyltranspeptidase","Gamma-GT","Gamma-glutamyltransferase heavy chain","Gamma-glutamyltransferase light chain"],"enzyme_classes":["2.3.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring amino-acyl groups"},{"category":"Function","description":" gamma-glutamyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"G_glu_transpept","identifier":"PF01019"}],"pathways":[{"name":"Taurine and hypotaurine metabolism","kegg_map_id":"00430"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Cyanoamino acid metabolism","kegg_map_id":"00460"},{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Arachidonic acid metabolism","kegg_map_id":"00590"}],"gene_sequence":"ATGCTGTTGTGTAATAGAAAAGTCCCCAAGACTTTAAATACCTGTTTTATACTGCATATATTCACTCTGTTAACACTGGGTGTGTTAGTGTCCGGAATGCCGTCAAAAATGGTATCATTCGCCTCTCAGGAGACTTTGCAGAGAATAAATAATCTCCTTCGAGGGTCTGCCAATCGAGATGTTGACATTATTGCAGAATATTTGAAAAAAGACGACGATGATGATGGCGGCGATAAGGATCACCATAACATCGATATTGACCCTTTACCTCGCCGTCCTAGTTTAACGCCTGATAGGCAACTTCTAAAAGTCGGTTTGCATGGTGCTATAAGTTCAGATTTAGAAGTCTGTAGTAATTTGACTATAAATGAGGTACTCCTGAAATTTCCCGGTTCTAACGCTGCAGACGCTGCAGTAACACAAGCTCTTTGTAAGGGTATGGTGAATTTTTTTAATAGTGGGATTGGAGGTGGTGGCTACGTAGTTTTTTCTGGCAAAGACGATGAAGATCATCTATCCATTGATTTTAGAGAAAAAGCACCCATGGATTCACATAAGTTCATGTTCGAAAACTGCTCTCTATGCTCAAAAATAGGGGGTCTTGCTGTCGGTGTTCCAGGTGAATTGATGGGTCTCTATCGCCTCTTTAAAGAAAGAGGTAGCGGCCAAGTTGATTGGCGTGATCTAATTGAACCAGTCGCAAAGCTGGGAAGCGTGGGTTGGCAAATAGGCGAAGCACTCGGTGCCACTTTAGAACTTTATGAGGATGTTTTCCTGACATTGAAGGAAGATTGGTCGTTTGTATTGAATTCTACCCATGACGGTGTTTTGAAAGAAGGCGATTGGATCAAGAGGCCGGCACTATCTAACATGCTAATGGAACTGGCTAAAAATGGTTCCGTGGCCCCATTTTATGACCCCGATCACTGGATTGCAAAATCCATGATTGATACTGTCGCAAAATACAATGGAATAATGAACTTGCAGGATGTTTCATCGTATGATGTTCATGTTACTAAACCACTGTCCATGAAAATTAGGAAGGGCGCCAATTTCATCCCTGATAACGATATGACCGTATTAACAAGTAGCGGCTCAAGTTCCGGGGCTGCACTACTTGCGGCGTTAAGGATAATGGATAATTTCCAGAATCAAGAAGGGGGCGATTATGAAAAAGAAACTACCTATCATTTGCTTGAAAGCATGAAATGGATGGCAAGCGCAAGAAGCAGGTTAGGCGATTTTGAAGGCGAAGCATTACCTAAGCATATAGAAGAGGTATTGGATCCAGAATGGGCTTTGAAAGCAGTGAAATCAATCAAAAGAAACTCTCAAGACGGAAATTTTAAAACTTTAGAAAACTGGACGCTTTATGATCCGGCATACGATATCAATAACCCGCATGGAACTGCCCACTTCAGTATAGTAGATTCACATGGGAATGCTGTTTCCTTGACAACCACCATCAACTTGTTGTTCGGTTCCTTAGTACACGACCCAAAAACCGGGGTGATCTTCAATAATGAAATGGACGATTTCGCTCAATTCAACAAATCTAATAGTTTTGAATTGGCACCCTCCATATACAACTTTCCCGAGCCCGGGAAAAGACCCCTATCATCCACTGCACCCACTATTGTGCTGTCAGAATTAGGCATCCCAGACCTCGTGGTCGGCGCTTCCGGCGGCTCAAGAATCACTACGAGTGTTTTACAAACAATTGTGAGGACGTACTGGTATAACATGCCTATATTGGAAACGATAGCCTATCCACGTATACACCACCAGTTACTGCCCGACCGCATAGAACTGGAAAGCTTCCCCATGATCGGTAAAGCCGTACTAAGCACTCTCAAGGAAATGGGATATACGATGAAAGAAGTATTTCCCAAGAGCGTAGTTAATGCTATACGCAATGTCAGGGGAGAATGGCATGCGGTGAGTGACTATTGGAGAAAAAGAGGAATCTCCTCCGTATACTAA","protein_sequence":"MLLCNRKVPKTLNTCFILHIFTLLTLGVLVSGMPSKMVSFASQETLQRINNLLRGSANRDVDIIAEYLKKDDDDDGGDKDHHNIDIDPLPRRPSLTPDRQLLKVGLHGAISSDLEVCSNLTINEVLLKFPGSNAADAAVTQALCKGMVNFFNSGIGGGGYVVFSGKDDEDHLSIDFREKAPMDSHKFMFENCSLCSKIGGLAVGVPGELMGLYRLFKERGSGQVDWRDLIEPVAKLGSVGWQIGEALGATLELYEDVFLTLKEDWSFVLNSTHDGVLKEGDWIKRPALSNMLMELAKNGSVAPFYDPDHWIAKSMIDTVAKYNGIMNLQDVSSYDVHVTKPLSMKIRKGANFIPDNDMTVLTSSGSSSGAALLAALRIMDNFQNQEGGDYEKETTYHLLESMKWMASARSRLGDFEGEALPKHIEEVLDPEWALKAVKSIKRNSQDGNFKTLENWTLYDPAYDINNPHGTAHFSIVDSHGNAVSLTTTINLLFGSLVHDPKTGVIFNNEMDDFAQFNKSNSFELAPSIYNFPEPGKRPLSSTAPTIVLSELGIPDLVVGASGGSRITTSVLQTIVRTYWYNMPILETIAYPRIHHQLLPDRIELESFPMIGKAVLSTLKEMGYTMKEVFPKSVVNAIRNVRGEWHAVSDYWRKRGISSVY"},{"created_at":"2016-09-09T22:47:07.000Z","updated_at":"2016-09-09T22:47:08.000Z","name":"Cys-Gly metallodipeptidase DUG1","uniprot_id":"P43616","uniprot_name":"DUG1","enzyme":false,"transporter":false,"gene_name":"DUG1","num_residues":481,"molecular_weight":"52870.91","theoretical_pi":null,"general_function":"glutathione catabolic process","specific_function":"Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Functions also in a DUG2-DUG3-independent manner as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides.","reactions":[{"id":3832,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006357","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":"4G1P","cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Deficient in utilization of glutathione protein 1","GSH degradosomal complex subunit DUG1"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"cytoplasm"},{"category":"Function","description":"metallodipeptidase activity"},{"category":"Function","description":"omega peptidase activity"},{"category":"Function","description":"tripeptidase activity"},{"category":"Function","description":"glutathione catabolic process"},{"category":"Function","description":"metal ion binding"}],"pfams":[],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGTCTCACTCACTTACTTCCGTTTTCCAAAAGATTGATTCTTTAAAGCCTCAGTTCTTCAGCAGACTGACTAAGGCTATTCAAATCCCCGCTGTTTCTTCGGATGAATCACTAAGGTCCAAAGTCTTCGATAAGGCCAAGTTTATCTCCGAGCAATTATCACAATCGGGGTTCCATGACATTAAAATGGTGGATCTGGGCATTCAACCTCCACCAATTTCTACGCCAAATCTGTCTCTACCTCCTGTGATTCTGTCTAGGTTCGGCAGCGACCCTTCAAAAAAGACTGTGTTGGTTTACGGTCACTATGATGTGCAACCTGCTCAATTGGAAGATGGTTGGGATACTGAGCCATTCAAGCTTGTCATTGATGAGGCTAAAGGTATCATGAAAGGAAGGGGTGTCACCGATGACACTGGTCCCTTATTATCTTGGATTAACGTTGTGGACGCCTTCAAAGCCTCCGGACAAGAATTCCCCGTTAACTTAGTTACTTGTTTCGAAGGAATGGAGGAAAGTGGTTCTTTGAAATTGGATGAATTGATTAAAAAGGAAGCTAATGGTTACTTTAAAGGTGTAGATGCCGTTTGTATTTCCGATAATTACTGGCTAGGCACTAAGAAGCCTGTTTTGACTTATGGTCTAAGAGGTTGCAACTACTATCAAACCATCATTGAGGGTCCAAGTGCAGATTTACACTCTGGTATCTTTGGTGGTGTTGTTGCTGAACCAATGATCGATTTAATGCAAGTTCTCGGTTCCCTTGTGGATTCTAAGGGTAAGATCCTGATTGACGGTATTGACGAAATGGTTGCTCCTCTAACCGAAAAGGAGAAGGCTCTATACAAGGATATCGAATTTAGCGTCGAAGAATTGAACGCTGCAACTGGCTCTAAGACAAGTTTGTACGACAAGAAGGAAGACATCTTGATGCACAGATGGAGGTATCCTTCGTTGTCCATTCATGGTGTGGAAGGCGCCTTTTCCGCTCAAGGTGCAAAGACTGTCATTCCAGCTAAGGTCTTCGGTAAGTTTTCCATTAGAACCGTCCCCGACATGGATTCTGAGAAACTGACCTCTTTGGTCCAGAAGCATTGTGATGCCAAATTCAAGTCCTTGAACTCTCCAAACAAGTGCAGAACAGAATTGATCCATGATGGTGCTTATTGGGTTTCTGATCCATTCAACGCCCAATTTACTGCTGCTAAAAAGGCCACAAAACTGGTCTATGGTGTCGATCCTGATTTTACCAGGGAAGGTGGTTCCATTCCTATCACTTTGACTTTCCAAGATGCCTTGAACACTAGTGTCTTATTGCTGCCAATGGGTAGAGGCGATGATGGTGCTCATTCAATCAATGAAAAGTTAGATATTTCAAATTTTGTTGGTGGTATGAAGACGATGGCTGCTTACTTGCAATATTACTCTGAATCGCCAGAAAACTAA","protein_sequence":"MSHSLTSVFQKIDSLKPQFFSRLTKAIQIPAVSSDESLRSKVFDKAKFISEQLSQSGFHDIKMVDLGIQPPPISTPNLSLPPVILSRFGSDPSKKTVLVYGHYDVQPAQLEDGWDTEPFKLVIDEAKGIMKGRGVTDDTGPLLSWINVVDAFKASGQEFPVNLVTCFEGMEESGSLKLDELIKKEANGYFKGVDAVCISDNYWLGTKKPVLTYGLRGCNYYQTIIEGPSADLHSGIFGGVVAEPMIDLMQVLGSLVDSKGKILIDGIDEMVAPLTEKEKALYKDIEFSVEELNAATGSKTSLYDKKEDILMHRWRYPSLSIHGVEGAFSAQGAKTVIPAKVFGKFSIRTVPDMDSEKLTSLVQKHCDAKFKSLNSPNKCRTELIHDGAYWVSDPFNAQFTAAKKATKLVYGVDPDFTREGGSIPITLTFQDALNTSVLLLPMGRGDDGAHSINEKLDISNFVGGMKTMAAYLQYYSESPEN"}]}