{"ymdb_id":"YMDB00158","created_at":"2011-05-29T16:02:25.000Z","updated_at":"2016-09-08T18:35:07.000Z","name":"O-Acetyl-L-homoserine","cas":"7540-67-2","state":null,"melting_point":null,"description":"O-Acetyl-L-homoserine is an intermediate in the biosynthesis of the amino acid L-homocysteine from L-homoserine. [Biocyc PWY-5344]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":null,"chebi_id":"16288","hmdb_id":null,"kegg_id":"C01077","pubchem_id":"439389","cs_id":"388506","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2S)-4-(acetyloxy)-2-aminobutanoic acid","traditional_iupac":"O-acetyl-L-homoserine","logp":"-3.387033704166865","pka":null,"alogps_solubility":"8.39e+01 g/l","alogps_logp":"-2.87","alogps_logs":"-0.28","acceptor_count":"4","donor_count":"2","rotatable_bond_count":"5","polar_surface_area":"89.62","refractivity":"36.057900000000004","polarizability":"15.619042677153525","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.458194751674373","pka_strongest_acidic":"2.015703027729805","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["O-Acetyl-L-homoserine","O-Acetylhomoserine"],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":5764336,"citation":"Cherest, H., Eichler, F., Robichon-Szulmajster, H. (1969). \"Genetic and regulatory aspects of methionine biosynthesis in Saccharomyces cerevisiae.\" J Bacteriol 97:328-336."},{"pubmed_id":15042590,"citation":"Mulet, J. M., Alemany, B., Ros, R., Calvete, J. J., Serrano, R. (2004). \"Expression of a plant serine O-acetyltransferase in Saccharomyces cerevisiae confers osmotic tolerance and creates an alternative pathway for cysteine biosynthesis.\" Yeast 21:303-312."},{"pubmed_id":16232856,"citation":"Kosuge, T., Gao, D., Hoshino, T. (2000). \"Analysis of the methionine biosynthetic pathway in the extremely thermophilic eubacterium Thermus thermophilus.\" J Biosci Bioeng 90:271-279."}],"proteins":[{"created_at":"2011-05-24T21:17:06.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Homoserine O-acetyltransferase","uniprot_id":"P08465","uniprot_name":"MET2_YEAST","enzyme":true,"transporter":false,"gene_name":"MET2","num_residues":486,"molecular_weight":"53659.0","theoretical_pi":"5.35","general_function":"Involved in O-acetyltransferase activity","specific_function":"Acetyl-CoA + L-homoserine = CoA + O-acetyl-L- homoserine","reactions":[{"id":1642,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2377,"direction":"\u003e","locations":null,"altext":"Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.","export":false,"pw_reaction_id":null,"source":null},{"id":3774,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006296","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z71553","genbank_protein_id":"1302344","gene_card_id":"MET2","chromosome_location":"chromosome 14","locus":"YNL277W","synonyms":["Homoserine O-trans-acetylase"],"enzyme_classes":["2.3.1.31"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Function","description":" homoserine O-acetyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" O-acyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" O-acetyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" sulfur amino acid metabolic process"},{"category":"Process","description":" sulfur amino acid biosynthetic process"},{"category":"Process","description":" methionine biosynthetic process"}],"pfams":[{"name":"Abhydrolase_1","identifier":"PF00561"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Sulfur metabolism","kegg_map_id":"00920"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGTCGCATACTTTAAAATCGAAAACGCTCCAAGAGCTGGACATTGAGGAGATTAAGGAAACTAACCCATTGCTCAAACTAGTTCAAGGGCAGAGGATTGTTCAAGTTCCGGAACTAGTGCTTGAGTCTGGCGTGGTCATAAATAATTTCCCTATTGCTTATAAGACGTGGGGTACACTGAATGAAGCTGGTGATAATGTTCTGGTAATTTGTCATGCCTTGACTGGGTCCGCAGATGTTGCTGACTGGTGGGGCCCTCTTCTGGGTAACGACTTAGCATTCGACCCATCAAGGTTTTTTATCATATGTTTAAACTCTATGGGCTCTCCATATGGGTCTTTTTCGCCATTAACGATAAATGAGGAGACGGGCGTTAGATATGGACCCGAATTCCCATTATGTACTGTGCGCGATGACGTTAGAGCTCACAGAATTGTTCTGGATTCTCTGGGAGTAAAGTCAATAGCCTGTGTTATTGGTGGCTCTATGGGGGGGATGCTGAGTTTGGAATGGGCTGCCATGTATGGTAAGGAATATGTGAAGAATATGGTTGCTCTGGCGACATCAGCAAGACATTCTGCCTGGTGCATATCGTGGTCTGAGGCTCAAAGACAATCGATTTACTCAGATCCCAACTACTTGGACGGGTACTATCCGGTAGAGGAGCAACCTGTGGCCGGACTATCGGCTGCACGTATGTCTGCATTGTTGACGTACAGGACAAGAAACAGTTTCGAGAACAAATTCTCCAGAAGATCTCCTTCAATAGCACAACAACAAAAAGCTCAAAGGGAGGAGACACGCAAACCATCTACTGTCAGCGAACACTCCCTACAAATCCACAATGATGGGTATAAAACAAAAGCCAGCACTGCCATCGCTGGCATTTCTGGGCAAAAAGGTCAAAGCGTGGTGTCCACCGCATCTTCTTCGGATTCATTGAATTCTTCAACATCGATGACTTCGGTAAGTTCTGTAACGGGTGAAGTGAAGGACATAAAGCCTGCGCAGACGTATTTTTCTGCACAAAGTTACTTGAGGTACCAGGGCACAAAGTTCATCAATAGGTTCGACGCCAATTGTTACATTGCCATCACACGTAAACTGGATACGCACGATTTGGCAAGAGACAGAGTAGATGACATCACTGAGGTCCTTTCTACCATCCAACAACCATCCCTGATCATCGGTATCCAATCTGATGGACTGTTCACATATTCAGAACAAGAATTTTTGGCTGAGCACATACCGAAGTCGCAATTAGAAAAAATTGAATCTCCCGAAGGCCACGATGCCTTCCTATTGGAGTTTAAGCTGATAAACAAACTGATAGTACAATTTTTAAAAACCAACTGCAAGGCCATTACCGATGCCGCTCCAAGAGCTTGGGGAGGTGACGTTGGTAACGATGAAACGAAGACGTCTGTCTTTGGTGAGGCCGAAGAAGTTACCAACTGGTAG","protein_sequence":"MSHTLKSKTLQELDIEEIKETNPLLKLVQGQRIVQVPELVLESGVVINNFPIAYKTWGTLNEAGDNVLVICHALTGSADVADWWGPLLGNDLAFDPSRFFIICLNSMGSPYGSFSPLTINEETGVRYGPEFPLCTVRDDVRAHRIVLDSLGVKSIACVIGGSMGGMLSLEWAAMYGKEYVKNMVALATSARHSAWCISWSEAQRQSIYSDPNYLDGYYPVEEQPVAGLSAARMSALLTYRTRNSFENKFSRRSPSIAQQQKAQREETRKPSTVSEHSLQIHNDGYKTKASTAIAGISGQKGQSVVSTASSSDSLNSSTSMTSVSSVTGEVKDIKPAQTYFSAQSYLRYQGTKFINRFDANCYIAITRKLDTHDLARDRVDDITEVLSTIQQPSLIIGIQSDGLFTYSEQEFLAEHIPKSQLEKIESPEGHDAFLLEFKLINKLIVQFLKTNCKAITDAAPRAWGGDVGNDETKTSVFGEAEEVTNW"},{"created_at":"2011-05-26T16:29:03.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"Putative cystathionine gamma-synthase YML082W","uniprot_id":"Q04533","uniprot_name":"METX_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":649,"molecular_weight":"74312.70313","theoretical_pi":"5.02","general_function":"Involved in pyridoxal phosphate binding","specific_function":"O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate","reactions":[{"id":1421,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1801,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2421,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z46660","genbank_protein_id":"575721","gene_card_id":null,"chromosome_location":null,"locus":"YML082W","synonyms":["O-succinylhomoserine (thiol)-lyase"],"enzyme_classes":["2.5.1.48"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGGTTTCAGCGCAAGTGGCTACCGAGCTAGGACAGCCTATACCACTGGACACTCAACATGCGGTATCTGTATGTTTCCCGACATGGAAATCTGTAATTTCGTATGTGGAGAAAGACCCCAAAGTTTTAGGGTGTTTAAAGTCTGGCTACCCCAGGTTTTGGATCCACCCCTCGATTCAAAAGCTGCGTGATATTTTAATAGAAAAGTATGCTAAAGAAAACGAAACGTGCTTTTGCTTCCCCTCTTATAGAGTTGCCAAACGGTGCAGAGAGTATGTAAGAAGGAAGTGCGCGCATCGCAATGGCAAAGTAAGGATATTACAGTTAGCCACGGCGAAACCTATCAACGAGGAGCAGAAGACGTGGAAAAGAGAGTGTAAGATTGCGGTAGTGTTTGTAGATGGGGCATACGAGAATATATTAAAACAGTATTGGCAATACACCGGAGAGATCATCTCAAGCAGACTAGCTGAATATGTTTTGCATGAACTTTTCATGGTAGAAAAGAAATCCAGCCCTGCAGAGGAAAAGGAATACATAGAGATGCGGTATGGCAGGAATCTGAATTTTGCATTTGCCGATCGAGCCAAGGAATTGATTAAGAAGAGGATCGCTACAAAGGTTATAGATAAAGATGAGCACGATGAGGAGGAAAACTACCATTTCTTAGCAGGTAACCAAGATGAACAGGACTTCCAGGACACGTTTCTGGATTCATCCCTCAATGAGGCTAACCACGGAGAAGATCATGACGGCGGGATTAGCGGTGAAGTAGACAGTCAAGAAGAACCGCATAATGGCCTTGTTTCCACTATACCCCCGGAGCCCATCGAAATGAGCACGATAGAGGAAGAGCAATCCGTAGAGGAAGATGCCGGGAGGTGTGCATTAAGGGTTTGCCCTGAGAGAGACGTTTTTTTGTTTCCGAGCGGCATGGCGTCGATATTCACTGCGCATAGATTGCTGTTGCAATGGGACTCACTGCGTTTGAATAGATCCAGAAATGGAAGCGACGTCACCTCGTCACCTCCGAATAAGAAGACCGTGATTTTTGGGTTCCCTTATGCGGATACATTACATGTCTTGCAAGAGTTTAATGAAACGTATTTCTTGGGAGAAGGAGATGAGTCTTCAATGAAAGAACTAACAAAAATTTTACATTCCGGGGAGCAAATTCTTGCCGTTTTTATAGAGACCCCATCAAACCCACTATTAAAAATGGGAAATTTACTGGAACTGAAAAGGCTTTCGGAATTATTTGGGTTTTTCATTATCATTGATGAAACTGTGGGTGGAATAGTTAATATTGACGGTCTACCGTTTGCTGATATCGTTTGCAGTTCATTGACGAAGACATTTAGTGGGGACTCTAACGTCATTGGTGGTTCAATGGTTTTAAATCCACAAAGCCGGGTATACGAGTTTGCCTCCCGTTTTATGCAATTAGAAGACGAATATGAAGATTTATTATGGTGCGAAGACGCAATTTACCTGGAAAGAAATTCCAGAGATTTCATTGCTAGAACCATCAGGATCAACTACAGCACCGAATACCTCTTAGATAAAATACTGAAGCCACACGTAGGCGAAAATAAACTATTCAAGAAAATCTACTACCCTAATCTAACCTCAAAAGAAACACTAACCAACTATGACATGGTGAGGTGTAAGAAAGAAGGTGGATACGGCGGGCTCTTTTCACTAACGTTCCATGACGAAGATCATGCTGCGGCCTTTTATGACAATCTAAAGCTGAACAAGGGTCCTTCCTTGGGCACAAATTTCACACTCGCATTCCCCTATACGCTCATGACATACTACCACGAACTCGACATGGCTGAAAAATTTGGGGTTGAGAGAAATCTTCTCAGAATCAGCGTAGGCCTCGAAAGTCAGTCAATATTGGGCAAGATCTTCCAAGAGGCAATTGATAAAACGGTAGAAATATGA","protein_sequence":"MVSAQVATELGQPIPLDTQHAVSVCFPTWKSVISYVEKDPKVLGCLKSGYPRFWIHPSIQKLRDILIEKYAKENETCFCFPSYRVAKRCREYVRRKCAHRNGKVRILQLATAKPINEEQKTWKRECKIAVVFVDGAYENILKQYWQYTGEIISSRLAEYVLHELFMVEKKSSPAEEKEYIEMRYGRNLNFAFADRAKELIKKRIATKVIDKDEHDEEENYHFLAGNQDEQDFQDTFLDSSLNEANHGEDHDGGISGEVDSQEEPHNGLVSTIPPEPIEMSTIEEEQSVEEDAGRCALRVCPERDVFLFPSGMASIFTAHRLLLQWDSLRLNRSRNGSDVTSSPPNKKTVIFGFPYADTLHVLQEFNETYFLGEGDESSMKELTKILHSGEQILAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPFADIVCSSLTKTFSGDSNVIGGSMVLNPQSRVYEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFIARTIRINYSTEYLLDKILKPHVGENKLFKKIYYPNLTSKETLTNYDMVRCKKEGGYGGLFSLTFHDEDHAAAFYDNLKLNKGPSLGTNFTLAFPYTLMTYYHELDMAEKFGVERNLLRISVGLESQSILGKIFQEAIDKTVEI"},{"created_at":"2011-05-26T16:30:36.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Protein MET17","uniprot_id":"P06106","uniprot_name":"MET17_YEAST","enzyme":true,"transporter":false,"gene_name":"MET17","num_residues":444,"molecular_weight":"48671.39844","theoretical_pi":"6.41","general_function":"Involved in pyridoxal phosphate binding","specific_function":"Transforms O-acetylhomoserine into homocysteine and O- acetylserine into cysteine","reactions":[{"id":1797,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1798,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2422,"direction":"\u003e","locations":"Cytoplasm","altext":"O-acetyl-L-homoserine + methanethiol = L-methionine + acetate.","export":false,"pw_reaction_id":null,"source":null},{"id":2420,"direction":"\u003e","locations":"Cytoplasm","altext":"O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate.","export":false,"pw_reaction_id":null,"source":null},{"id":3775,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006297","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY723848","genbank_protein_id":"51830472","gene_card_id":"MET17","chromosome_location":"chromosome 12","locus":"YLR303W","synonyms":["O-acetylhomoserine sulfhydrylase","OAH sulfhydrylase","Homocysteine synthase","O-acetylserine sulfhydrylase","OAS sulfhydrylase"],"enzyme_classes":["2.5.1.49","2.5.1.47"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGCCATCTCATTTCGATACTGTTCAACTACACGCCGGCCAAGAGAACCCTGGTGACAATGCTCACAGATCCAGAGCTGTACCAATTTACGCCACCACTTCTTATGTTTTCGAAAACTCTAAGCATGGTTCGCAATTGTTTGGTCTAGAAGTTCCAGGTTACGTCTATTCCCGTTTCCAAAACCCAACCAGTAATGTTTTGGAAGAAAGAATTGCTGCTTTAGAAGGTGGTGCTGCTGCTTTGGCTGTTTCCTCCGGTCAAGCCGCTCAAACCCTTGCCATCCAAGGTTTGGCACACACTGGTGACAACATCGTTTCCACTTCTTACTTATACGGTGGTACTTATAACCAGTTCAAAATCTCGTTCAAAAGATTTGGTATCGAGGCTAGATTTGTTGAAGGTGACAATCCAGAAGAATTCGAAAAGGTCTTTGATGAAAGAACCAAGGCTGTTTATTTGGAAACCATTGGTAATCCAAAGTACAATGTTCCGGATTTTGAAAAAATTGTTGCAATTGCTCACAAACACGGTATTCCAGTTGTCGTTGACAACACATTTGGTGCCGGTGGTTACTTCTGTCAGCCAATTAAATACGGTGCTGATATTGTAACACATTCTGCTACCAAATGGATTGGTGGTCATGGTACTACTATCGGTGGTATTATTGTTGACTCTGGTAAGTTCCCATGGAAGGACTACCCAGAAAAGTTCCCTCAATTCTCTCAACCTGCCGAAGGATATCACGGTACTATCTACAATGAAGCCTACGGTAACTTGGCATACATCGTTCATGTTAGAACTGAACTATTAAGAGATTTGGGTCCATTGATGAACCCATTTGCCTCTTTCTTGCTACTACAAGGTGTTGAAACATTATCTTTGAGAGCTGAAAGACACGGTGAAAATGCATTGAAGTTAGCCAAATGGTTAGAACAATCCCCATACGTATCTTGGGTTTCATACCCTGGTTTAGCATCTCATTCTCATCATGAAAATGCTAAGAAGTATCTATCTAACGGTTTCGGTGGTGTCTTATCTTTCGGTGTAAAAGACTTACCAAATGCCGACAAGGAAACTGACCCATTCAAACTTTCTGGTGCTCAAGTTGTTGACAATTTAAAGCTTGCCTCTAACTTGGCCAATGTTGGTGATGCCAAGACCTTAGTCATTGCTCCATACTTCACTACCCACAAACAATTAAATGACAAAGAAAAGTTGGCATCTGGTGTTACCAAGGACTTAATTCGTGTCTCTGTTGGTATCGAATTTATTGATGACATTATTGCAGACTTCCAGCAATCTTTTGAAACGGTTTTCGCTGGCCAAAAACCATGA","protein_sequence":"MPSHFDTVQLHAGQENPGDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTFGAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDYPEKFPQFSQPAEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSNGFGGVLSFGVKDLPNADKETDPFKLSGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETVFAGQKP"},{"created_at":"2011-05-26T16:33:53.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"Cystathionine gamma-synthase","uniprot_id":"P47164","uniprot_name":"MET7_YEAST","enzyme":true,"transporter":false,"gene_name":"STR2","num_residues":639,"molecular_weight":"72349.89844","theoretical_pi":"5.88","general_function":"Involved in pyridoxal phosphate binding","specific_function":"O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate","reactions":[{"id":1421,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2421,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate.","export":false,"pw_reaction_id":null,"source":null},{"id":14296,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006793","source":"Smpdb"},{"id":14297,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006794","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"AY692979","genbank_protein_id":"51013409","gene_card_id":"STR2","chromosome_location":"chromosome 10","locus":"YJR130C","synonyms":["O-succinylhomoserine (thiol)-lyase","Sulfur transfer protein 2"],"enzyme_classes":["2.5.1.48"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGATATCTAGAACCATTGGTGAATCTATTCCGCCCAACACAAAACATGCTGTTTCCGTGTGTTTGCCCACATGGGAAGCTACAGTAGGCTATGAAGAGGGTGAAAGCAGTATAATTAACTCGCTTACTACCGGATATCCAAGATTTTTCATACACAAGTCAATAAAGAAATTATGTGAAATTTTATCCGCTAAGTACTCCATGGAAGATGAAGCTTGTCTTTGCTTCCCCTCTTACAAGGTTGCCAATAGGTGCAGAGAGTTTATCAAAGTGAAAACGGGTCTTTCTACCAAAGTACGCATCTTACAACTATGTACACCTAAACCTATGAACCAAGAGGAAAAGCTCTGGAGAAGGGAATGTAAAATCACGGTGGTGTTTGTAGACCAGGAAATATTCCCCGTGATGAAGCAGTATTGGCAACATTCTGGTGAGATTGTATCTAGCAGAATGGCGGAGTATATTTTACATGAATTACAAGTCAAGGATAATCTTAAGAAGATGGAAACAGTGGATAACGGTAAAAAATTTATGACCGAAGATGAAAACAGAGTGAACGAAGAATATATAGAAACGAGATTTGGGAGAAATTTAAATTTTCTTGCTGCTGATAAAGCCAAATATCTAATACGAAAGAGGATTGCCACAAAAGTTGTTGAAAAAATTGACTCTGAAGGTCTATCGGACCTATTCTCTTTTGAACACTATAACGAGAGCAACGGTCCATTCAATGTTGGCAGTGGAGAGGCTCTGGATGATGATCAGTTGAATTCGGACATACCTGCCGAAACAATTACTTCTATGGGAGAAAGTGGCTCAAACAGTACTTTTGAAAACACAGCTACCGATGACTTGAAGTTTCATGTCAACCCTAATACGGATGTTTACTTATTTCCAAGTGGAATGGCGTCCATTTTCACTGCCCACAGGCTGCTTTTAAACTTCGATGCCAAGCGCTTATCAAGGTCTTCTAGTAGACAAGATAAGTTGATTGGATATGGACCTCCGTTCAAGAAGACCGTCATGTTTGGATTCCCATATACAGATACTCTGAGCATTCTTCGGAAGTTCAATCACACACATTTCTTGGGACAGGGAGATTCAACGTCAATGAACGCTCTGAAAAATATTTTACATTCTGGTGAGCAAATACTGGCGGTATTTATAGAAGCTCCATCGAACCCACTGTTGAAAATGGGAGATTTACAAGAACTGAAAAGGCTATCAGACTTGTATTCATTTTACATAGTGGTCGATGAAACTGTGGGTGGCTTTGTCAATATAGATGTATTACCGTATGCCGATATTGTTTGTAGTTCGCTAACGAAAATCTTCAGCGGCGACTCGAACGTTATTGCAGGATCCTTAGTACTAAATCCTAGAGGAAAGATTTATGAGTTTGCTAGAAAATTTATGAAGACTGAAGACGGATATGAAGATTGCCTATGGTGCGAAGATGCGTTATGCCTGGAAAGAAATTCGAGAGACTTCGTGGAACGTACAATCAAGGTGAATACAAACACTGATATATTGTTAAAAAGGGTGTTATTGCCTCAGGTGGGAAAATTGTTCAAGAAAATATATTACCCCAGTTTAACATCAGAGGATACCAAGCGGAATTATGACAGCGTTATGTCTACAAAAGATGGTGGGTATGGAGGTTTATTTTCACTAACTTTTTTCAATATTGAAGAGGCAAAGAAGTTTTTCAATAATCTGGAATTGTGCAAAGGACCTTCTCTCGGTACGAATTTCACTTTGGCGTGTCCATATGCTATTATTGCCCACTACCAGGAATTAGACGAGGTAGCTCAATATGGTGTCGAAACAAATCTTGTAAGAGTGAGCGTCGGTTTGGAAAATAGCGACGTTTTATGCAATGTTTTTCAGCGTGCCATTGAGAAAGCTTTAGGGGAATAA","protein_sequence":"MISRTIGESIPPNTKHAVSVCLPTWEATVGYEEGESSIINSLTTGYPRFFIHKSIKKLCEILSAKYSMEDEACLCFPSYKVANRCREFIKVKTGLSTKVRILQLCTPKPMNQEEKLWRRECKITVVFVDQEIFPVMKQYWQHSGEIVSSRMAEYILHELQVKDNLKKMETVDNGKKFMTEDENRVNEEYIETRFGRNLNFLAADKAKYLIRKRIATKVVEKIDSEGLSDLFSFEHYNESNGPFNVGSGEALDDDQLNSDIPAETITSMGESGSNSTFENTATDDLKFHVNPNTDVYLFPSGMASIFTAHRLLLNFDAKRLSRSSSRQDKLIGYGPPFKKTVMFGFPYTDTLSILRKFNHTHFLGQGDSTSMNALKNILHSGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPYADIVCSSLTKIFSGDSNVIAGSLVLNPRGKIYEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTNTDILLKRVLLPQVGKLFKKIYYPSLTSEDTKRNYDSVMSTKDGGYGGLFSLTFFNIEEAKKFFNNLELCKGPSLGTNFTLACPYAIIAHYQELDEVAQYGVETNLVRVSVGLENSDVLCNVFQRAIEKALGE"}]}