{"ymdb_id":"YMDB00371","created_at":"2011-05-29T18:10:29.000Z","updated_at":"2016-09-08T18:35:24.000Z","name":"Homocysteine","cas":"454-29-5","state":"Solid","melting_point":"232-233 oC","description":"Homocysteine is a sulfur-containing amino acid that arises during methionine metabolism. Homocysteine can be recycled into methionine or converted into cysteine with the aid of B-vitamins.","experimental_water_solubility":"148 mg/mL [HMP experimental]","experimental_logp_hydrophobicity":"","location":null,"synthesis_reference":"Karrenbauer, Michael; Kleemann, Axel; Luessling, Theodor; Schaefer, Fritz.  D,L-Homocysteine (I).    Ger.  (1984),     4 pp.","chebi_id":"17230","hmdb_id":"HMDB00742","kegg_id":"C05330","pubchem_id":"778","cs_id":"757","foodb_id":null,"wikipedia_link":"Homocysteine","biocyc_id":"HOMO-CYS","iupac":"2-amino-4-sulfanylbutanoic acid","traditional_iupac":"homocysteine","logp":"-2.5764673824810185","pka":"10.279400411474743","alogps_solubility":"1.48e+01 g/l","alogps_logp":"-2.29","alogps_logs":"-0.96","acceptor_count":"3","donor_count":"3","rotatable_bond_count":"3","polar_surface_area":"63.31999999999999","refractivity":"32.935","polarizability":"13.436789867145489","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.413365429707895","pka_strongest_acidic":"2.458553724459435","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(+-)-homocysteine","(S)-2-amino-4-mercapto-Butanoate","(S)-2-amino-4-mercapto-Butanoic acid","2-amino-4-mercapto-Butanoate","2-amino-4-mercapto-Butanoic acid","2-amino-4-mercapto-Butyric acid","2-amino-4-mercapto-DL-Butyrate","2-amino-4-mercapto-DL-Butyric acid","2-Amino-4-mercaptobutyric acid","2-amino-4-sulfanylbutanoate","2-amino-4-sulfanylbutanoic acid","D,l-homocysteine","DL-2-amino-4-mercapto-Butyric acid","DL-2-Amino-4-mercaptobutyric acid","DL-Homocysteine","DL-homocysteine (free base)","HCY","Homo-CYS","homocysteine","L-2-amino-4-mercapto-Butyric acid","L-Homocysteine","Usaf B-12"],"pathways":[{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"One Carbon Pool by Folate I","kegg_map_id":null},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."}],"proteins":[{"created_at":"2011-05-26T16:30:36.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Protein MET17","uniprot_id":"P06106","uniprot_name":"MET17_YEAST","enzyme":true,"transporter":false,"gene_name":"MET17","num_residues":444,"molecular_weight":"48671.39844","theoretical_pi":"6.41","general_function":"Involved in pyridoxal phosphate binding","specific_function":"Transforms O-acetylhomoserine into homocysteine and O- acetylserine into cysteine","reactions":[{"id":1797,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1798,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2422,"direction":"\u003e","locations":"Cytoplasm","altext":"O-acetyl-L-homoserine + methanethiol = L-methionine + acetate.","export":false,"pw_reaction_id":null,"source":null},{"id":2420,"direction":"\u003e","locations":"Cytoplasm","altext":"O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate.","export":false,"pw_reaction_id":null,"source":null},{"id":3775,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006297","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY723848","genbank_protein_id":"51830472","gene_card_id":"MET17","chromosome_location":"chromosome 12","locus":"YLR303W","synonyms":["O-acetylhomoserine sulfhydrylase","OAH sulfhydrylase","Homocysteine synthase","O-acetylserine sulfhydrylase","OAS sulfhydrylase"],"enzyme_classes":["2.5.1.49","2.5.1.47"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGCCATCTCATTTCGATACTGTTCAACTACACGCCGGCCAAGAGAACCCTGGTGACAATGCTCACAGATCCAGAGCTGTACCAATTTACGCCACCACTTCTTATGTTTTCGAAAACTCTAAGCATGGTTCGCAATTGTTTGGTCTAGAAGTTCCAGGTTACGTCTATTCCCGTTTCCAAAACCCAACCAGTAATGTTTTGGAAGAAAGAATTGCTGCTTTAGAAGGTGGTGCTGCTGCTTTGGCTGTTTCCTCCGGTCAAGCCGCTCAAACCCTTGCCATCCAAGGTTTGGCACACACTGGTGACAACATCGTTTCCACTTCTTACTTATACGGTGGTACTTATAACCAGTTCAAAATCTCGTTCAAAAGATTTGGTATCGAGGCTAGATTTGTTGAAGGTGACAATCCAGAAGAATTCGAAAAGGTCTTTGATGAAAGAACCAAGGCTGTTTATTTGGAAACCATTGGTAATCCAAAGTACAATGTTCCGGATTTTGAAAAAATTGTTGCAATTGCTCACAAACACGGTATTCCAGTTGTCGTTGACAACACATTTGGTGCCGGTGGTTACTTCTGTCAGCCAATTAAATACGGTGCTGATATTGTAACACATTCTGCTACCAAATGGATTGGTGGTCATGGTACTACTATCGGTGGTATTATTGTTGACTCTGGTAAGTTCCCATGGAAGGACTACCCAGAAAAGTTCCCTCAATTCTCTCAACCTGCCGAAGGATATCACGGTACTATCTACAATGAAGCCTACGGTAACTTGGCATACATCGTTCATGTTAGAACTGAACTATTAAGAGATTTGGGTCCATTGATGAACCCATTTGCCTCTTTCTTGCTACTACAAGGTGTTGAAACATTATCTTTGAGAGCTGAAAGACACGGTGAAAATGCATTGAAGTTAGCCAAATGGTTAGAACAATCCCCATACGTATCTTGGGTTTCATACCCTGGTTTAGCATCTCATTCTCATCATGAAAATGCTAAGAAGTATCTATCTAACGGTTTCGGTGGTGTCTTATCTTTCGGTGTAAAAGACTTACCAAATGCCGACAAGGAAACTGACCCATTCAAACTTTCTGGTGCTCAAGTTGTTGACAATTTAAAGCTTGCCTCTAACTTGGCCAATGTTGGTGATGCCAAGACCTTAGTCATTGCTCCATACTTCACTACCCACAAACAATTAAATGACAAAGAAAAGTTGGCATCTGGTGTTACCAAGGACTTAATTCGTGTCTCTGTTGGTATCGAATTTATTGATGACATTATTGCAGACTTCCAGCAATCTTTTGAAACGGTTTTCGCTGGCCAAAAACCATGA","protein_sequence":"MPSHFDTVQLHAGQENPGDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTFGAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDYPEKFPQFSQPAEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSNGFGGVLSFGVKDLPNADKETDPFKLSGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETVFAGQKP"},{"created_at":"2011-05-26T16:49:52.000Z","updated_at":"2011-07-22T17:54:00.000Z","name":"Adenosylhomocysteinase","uniprot_id":"P39954","uniprot_name":"SAHH_YEAST","enzyme":true,"transporter":false,"gene_name":"SAH1","num_residues":449,"molecular_weight":"49125.10156","theoretical_pi":"6.2","general_function":"Involved in adenosylhomocysteinase activity","specific_function":"Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine","reactions":[{"id":1272,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2447,"direction":"\u003e","locations":"Cytoplasmic","altext":"S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.","export":false,"pw_reaction_id":null,"source":null},{"id":3786,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006308","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"AY692801","genbank_protein_id":"51013053","gene_card_id":"SAH1","chromosome_location":"chromosome 5","locus":"YER043C","synonyms":["AdoHcyase","S-adenosyl-L-homocysteine hydrolase"],"enzyme_classes":["3.3.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ether bonds"},{"category":"Function","description":" trialkylsulfonium hydrolase activity"},{"category":"Function","description":" adenosylhomocysteinase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" one-carbon metabolic process"}],"pfams":[{"name":"AdoHcyase","identifier":"PF05221"},{"name":"AdoHcyase_NAD","identifier":"PF00670"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGTCTGCTCCAGCTCAAAACTACAAAATCGCTGATATCTCTTTGGCTGCCTTCGGTAGAAAGGAAATCGAATTGGCTGAACATGAAATGCCAGGTTTGATGGCCATCAGAAAGGCTTACGGTGACGTCCAACCTTTGAAAGGCGCCCGTATTGCTGGTTGTTTGCACATGACCATTCAAACTGCTGTTTTAATTGAAACTTTAGTTGCTTTGGGTGCCGAAGTTACCTGGTCCTCTTGTAACATCTATTCGACTCAAGATCATGCCGCCGCTGCTATTGCCGCTTCCGGTGTTCCAGTTTTTGCCTGGAAGGGTGAAACTGAAGAAGAGTATTTGTGGTGTATTGAACAACAATTGTTTGCCTTCAAGGACAACAAGAAATTGAACTTGATCTTAGATGATGGTGGTGATTTAACCACTTTAGTTCATGAAAAGCACCCTGAAATGCTGGAAGACTGCTTTGGTCTTTCCGAAGAAACTACCACCGGTGTTCACCACTTATACAGAATGGTCAAAGAAGGCAAGTTAAAGGTTCCTGCCATTAACGTTAACGACTCCGTCACTAAGTCCAAGTTTGACAACTTGTACGGCTGTAGAGAATCCTTAGTCGACGGTATTAAGAGAGCCACTGATGTCATGTTGGCTGGTAAGGTTGCCGTTGTTGCTGGTTACGGTGATGTCGGTAAGGGTTGTGCTGCTGCCTTAAGAGGAATGGGTGCTCGTGTCTTGGTTACCGAAATTGACCCAATCAACGCTTTACAAGCTGCCATGGAAGGCTACCAAGTTGTTACCATGGAAGATGCATCCCACATTGGTCAAGTTTTCGTTACCACCACTGGTTGTAGAGATATTATCAACGGTGAACATTTCATCAACATGCCAGAAGATGCCATTGTTTGTAACATTGGCCATTTCGATATCGAAATTGATGTCGCCTGGTTAAAGGCTAACGCTAAAGAATGTATTAACATCAAACCACAAGTCGACCGTTACTTGTTGTCTTCTGGTAGACACGTCATCTTGTTGGCTAACGGTAGATTAGTTAACTTGGGTTGTGCTACTGGTCACTCATCTTTCGTTATGTCTTGTTCCTTCTCTAACCAAGTCTTAGCTCAAATTGCTTTGTTCAAGTCTAACGATAAGTCTTTCAGAGAAAAGCACATTGAATTCCAAAAGACAGGCCCATTCGAAGTTGGTGTCCACGTTTTGCCAAAGATCTTGGATGAAGCTGTCGCTAAGTTCCACTTGGGCAACTTGGGTGTTAGATTGACTAAATTGAGTAAAGTCCAATCTGAATACTTGGGTATTCCAGAAGAAGGTCCATTCAAGGCCGACCACTACAGATATTGA","protein_sequence":"MSAPAQNYKIADISLAAFGRKEIELAEHEMPGLMAIRKAYGDVQPLKGARIAGCLHMTIQTAVLIETLVALGAEVTWSSCNIYSTQDHAAAAIAASGVPVFAWKGETEEEYLWCIEQQLFAFKDNKKLNLILDDGGDLTTLVHEKHPEMLEDCFGLSEETTTGVHHLYRMVKEGKLKVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGMGARVLVTEIDPINALQAAMEGYQVVTMEDASHIGQVFVTTTGCRDIINGEHFINMPEDAIVCNIGHFDIEIDVAWLKANAKECINIKPQVDRYLLSSGRHVILLANGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKSNDKSFREKHIEFQKTGPFEVGVHVLPKILDEAVAKFHLGNLGVRLTKLSKVQSEYLGIPEEGPFKADHYRY"},{"created_at":"2011-05-26T17:54:29.000Z","updated_at":"2011-07-22T17:53:51.000Z","name":"5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase","uniprot_id":"P05694","uniprot_name":"METE_YEAST","enzyme":true,"transporter":false,"gene_name":"MET6","num_residues":767,"molecular_weight":"85859.20313","theoretical_pi":"6.41","general_function":"Involved in 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity","specific_function":"Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation","reactions":[{"id":1218,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1729,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2494,"direction":"\u003e","locations":null,"altext":"5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.","export":false,"pw_reaction_id":null,"source":null},{"id":3784,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006306","source":"Smpdb"},{"id":3785,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006776","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"DQ393811","genbank_protein_id":"88910023","gene_card_id":"MET6","chromosome_location":"chromosome 5","locus":"YER091C","synonyms":["Cobalamin-independent methionine synthase","Delta-P8 protein","Methionine synthase, vitamin-B12 independent isozyme"],"enzyme_classes":["2.1.1.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" S-methyltransferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" sulfur amino acid metabolic process"},{"category":"Process","description":" sulfur amino acid biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" methionine biosynthetic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Meth_synt_1","identifier":"PF08267"},{"name":"Meth_synt_2","identifier":"PF01717"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Selenocompound metabolism","kegg_map_id":"00450"}],"gene_sequence":"ATGGTTCAATCTGCTGTCTTAGGGTTCCCAAGAATCGGTCCAAACAGAGAATTAAAGAAGGCCACTGAAGGTTACTGGAACGGTAAAATCACTGTCGATGAATTATTCAAGGTCGGTAAGGATTTGAGAACTCAAAACTGGAAGTTGCAAAAGGAGGCTGGTGTTGATATCATCCCATCCAATGACTTCTCCTTTTACGACCAAGTTTTGGATTTGTCTTTGTTGTTCAATGTCATTCCAGACCGTTACACTAAGTACGATCTATCTCCAATCGACACTTTGTTTGCTATGGGTAGAGGTTTACAAAGAAAGGCCACTGAAACTGAAAAGGCTGTCGACGTCACTGCTTTGGAAATGGTTAAATGGTTCGACTCTAACTACCATTACGTTAGACCAACTTTCTCCAAGACCACTCAATTTAAGTTGAACGGCCAAAAGCCAGTTGACGAATTTTTGGAAGCCAAGGAGTTAGGTATTCATACTAGACCTGTCTTGTTGGGTCCAGTTTCTTACTTATTCTTGGGTAAGGCTGACAAGGATTCTCTAGATTTGGAACCATTGTCCCTATTGGAACAATTGTTGCCTCTATACACTGAAATCCTATCTAAATTGGCTTCTGCTGGTGCCACTGAAGTTCAAATTGACGAACCTGTCTTAGTTTTGGACTTGCCTGCCAACGCCCAAGCCGCCATTAAGAAGGCTTACACTTACTTCGGTGAACAAAGCAATCTACCAAAGATTACTTTGGCTACTTACTTCGGTACCGTTGTCCCTAACTTAGACGCCATCAAGGGCTTGCCAGTTGCTGCCTTACACGTTGACTTTGTTAGAGCTCCAGAACAATTTGATGAAGTCGTTGCCGCCATTGGTAACAAACAAACCTTGTCTGTTGGTATTGTTGATGGTAGAAACATTTGGAAGAATGATTTCAAGAAGTCTTCCGCTATCGTTAACAAGGCTATTGAAAAGTTGGGTGCTGACAGAGTCGTTGTTGCCACTTCTTCTTCTCTATTGCACACACCAGTTGATTTGAACAACGAAACCAAGTTGGACGCTGAAATCAAGGGCTTTTTCTCTTTCGCCACTCAAAAATTGGATGAAGTTGTTGTGATCACCAAGAACGTTTCCGGTCAAGACGTTGCTGCTGCCCTAGAAGCTAACGCTAAATCTGTTGAATCCAGAGGTAAATCCAAGTTTATCCACGATGCTGCCGTTAAGGCCAGAGTTGCCTCTATCGACGAAAAAATGTCTACTAGAGCAGCTCCATTTGAACAAAGATTGCCTGAACAACAAAAAGTCTTCAACTTGCCATTGTTCCCAACAACAACTATTGGTTCCTTCCCTCAAACCAAGGACATCAGAATTAACAGAAACAAATTCAACAAGGGTACCATCTCTGCTGAAGAATATGAAAAATTCATCAATTCTGAAATTGAAAAGGTCATCAGATTCCAAGAAGAAATTGGTTTGGATGTCTTAGTCCACGGTGAACCAGAAAGAAACGATATGGTTCAATACTTCGGTGAACAAATCAACGGTTATGCTTTCACTGTTAACGGTTGGGTTCAATCTTACGGTTCCAGATATGTCAGACCACCAATTATTGTTGGTGACTTGTCCAGACCAAAGGCTATGTCCGTCAAGGAATCTGTTTACGCTCAATCCATCACTTCTAAGCCAGTAAAGGGTATGTTGACTGGTCCAATTACCTGTTTGAGATGGTCTTTCCCAAGAGACGATGTCGACCAAAAAACTCAAGCTATGCAATTAGCTTTGGCTTTGAGAGATGAAGTCAATGATTTGGAAGCTGCCGGTATCAAGGTTATCCAAGTTGATGAACCAGCTTTAAGAGAAGGTTTACCATTGAGAGAAGGTACTGAGAGATCTGCTTACTACACCTGGGCTGCCGAAGCTTTCAGAGTTGCTACTTCTGGTGTTGCTAACAAGACTCAAATACACTCTCATTTCTGTTACTCTGACTTGGATCCAAACCATATCAAGGCTTTGGATGCTGATGTTGTTTCCATCGAATTCTCTAAGAAGGACGATGCTAACTACATTGCTGAATTCAAAAACTATCCAAACCACATTGGTCTAGGTTTATTCGATATTCATTCTCCAAGAATTCCATCAAAGGATGAATTTATCGCCAAGATTTCAACCATCTTGAAGAGCTACCCAGCTGAAAAGTTCTGGGTTAACCCAGATTGTGGTTTGAAGACTAGAGGCTGGGAAGAAACTAGATTGTCTTTGACTCATATGGTCGAAGCCGCCAAGTACTTCCGTGAACAATACAAGAATTAA","protein_sequence":"MVQSAVLGFPRIGPNRELKKATEGYWNGKITVDELFKVGKDLRTQNWKLQKEAGVDIIPSNDFSFYDQVLDLSLLFNVIPDRYTKYDLSPIDTLFAMGRGLQRKATETEKAVDVTALEMVKWFDSNYHYVRPTFSKTTQFKLNGQKPVDEFLEAKELGIHTRPVLLGPVSYLFLGKADKDSLDLEPLSLLEQLLPLYTEILSKLASAGATEVQIDEPVLVLDLPANAQAAIKKAYTYFGEQSNLPKITLATYFGTVVPNLDAIKGLPVAALHVDFVRAPEQFDEVVAAIGNKQTLSVGIVDGRNIWKNDFKKSSAIVNKAIEKLGADRVVVATSSSLLHTPVDLNNETKLDAEIKGFFSFATQKLDEVVVITKNVSGQDVAAALEANAKSVESRGKSKFIHDAAVKARVASIDEKMSTRAAPFEQRLPEQQKVFNLPLFPTTTIGSFPQTKDIRINRNKFNKGTISAEEYEKFINSEIEKVIRFQEEIGLDVLVHGEPERNDMVQYFGEQINGYAFTVNGWVQSYGSRYVRPPIIVGDLSRPKAMSVKESVYAQSITSKPVKGMLTGPITCLRWSFPRDDVDQKTQAMQLALALRDEVNDLEAAGIKVIQVDEPALREGLPLREGTERSAYYTWAAEAFRVATSGVANKTQIHSHFCYSDLDPNHIKALDADVVSIEFSKKDDANYIAEFKNYPNHIGLGLFDIHSPRIPSKDEFIAKISTILKSYPAEKFWVNPDCGLKTRGWEETRLSLTHMVEAAKYFREQYKN"},{"created_at":"2011-05-26T18:14:55.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"Cystathionine beta-lyase","uniprot_id":"P53101","uniprot_name":"STR3_YEAST","enzyme":true,"transporter":false,"gene_name":"STR3","num_residues":465,"molecular_weight":"51828.0","theoretical_pi":"8.1","general_function":"Involved in pyridoxal phosphate binding","specific_function":"L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate","reactions":[{"id":1418,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2518,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate.","export":false,"pw_reaction_id":null,"source":null},{"id":3776,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006298","source":"Smpdb"},{"id":3777,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006777","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"X91489","genbank_protein_id":"1143563","gene_card_id":"STR3","chromosome_location":"chromosome 7","locus":"YGL184C","synonyms":["CBL","Beta-cystathionase","Cysteine lyase","Sulfur transfer protein 3"],"enzyme_classes":["4.4.1.8"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" cystathionine beta-lyase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" carbon-sulfur lyase activity"},{"category":"Process","description":" sulfur amino acid biosynthetic process"},{"category":"Process","description":" methionine biosynthetic process"},{"category":"Process","description":" L-methionine biosynthetic process"},{"category":"Process","description":" 'de novo' L-methionine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" sulfur amino acid metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Sulfur metabolism","kegg_map_id":"00920"},{"name":"Cysteine Metabolism","kegg_map_id":null}],"gene_sequence":"ATGCCGATCAAGAGATTAGATACAGTTGTGGTAAATACCGGCTCTCAAAATGACCAACATTCAGCCTCCGTGCCACCGGTGTATTTGTCGACTACCTTCAAAGTGGACTTGAATAATGAAGATGCACAGAACTACGATTATTCCAGATCGGGAAACCCGACCAGAAGTGTCCTTCAACACCAGATTGGTAAGCTTTATCGTGTCCCACAGGAAAACGTATTAGCTGTGAGCAGTGGTATGACGGCGCTAGACGTCATCCTGCGTGGGCTCGTCTTACTTAACGGCACTGACAACCATACGCCAACAATAATAGCCGGCGATGATCTTTATGGAGGCACCCAAAGGCTGCTGAATTTTTTCAAGCAACAGAGTCATGCAGTCTCTGTTCATGTGGACACTTCCGATTTTGAAAAGTTCAAAACCGTTTTCCAGTCTTTAGATAAAGTTGATTGTGTTCTTCTAGAGTCTCCGACCAATCCGCTTTGCAAGGTTGTAGATATCCCTAGAATATTACGTTTTGTGAAATGCATATCTCCCGACACTACAGTTGTCGTTGATAATACTATGATGAGTGGACTCAATTGTAATCCTCTTCAACTGAATCCAGGCTGCGATGTCGTATACGAATCTGCTACCAAGTACTTGAATGGTCATCACGATTTGATGGGGGGTGTTATTATCAGCAAAACACCAGAAATAGCCTCGAAGCTTTACTTTGTCATTAATTCTACAGGAGCTGGATTATCCCCAATGGATTCTTGGCTACTTGTGAGGGGCCTAAAAACTCTAGGAGTTAGATTATATCAACAGCAGAGAAATGCTATGATATTGGCTCATTGGCTAGAAAATTCATGCGGATTCAAACCTACCAGAACAAACAAGGCTACGAAAACTAGATTTGTTGGATTACGCTCCAACCCGGATTTCAAGCTGCATAAATCGTTCAATAATGGCCCAGGTGCCGTGTTATCCTTCGAAACGGGGTCCTTCGAACATTCAAAGAGACTGGTCAGTTCCAAAAAACTGAGTATATGGGCTGTGACGGTATCTTTCGGGTGTGTAAATTCGCTTCTATCTATGCCTTGCAAAATGTCCCATGCTTCCATTGATCCCGAATTAAGGAAAGAGAGAGATTTTCCTGAAGATTTGGTTCGTCTTTGCTGCGGTATCGAAAATATAGTAGATTTGAAGAAAGATTTATTAGCGGCGATGGTTGACGCTGATATTATAGAAGTAAGAGAAAATGGCAAATATCTTTTCAACAAATTGAATAAGAACCTAGCTGTGAACACTACCATCGATGACCTGCATAAGCCTTTAAGTATTTACGAAGAATTTTACAATCAAGATCTCATCAGAAAGGACTCAGAATTGAATATTAAGAGTTCGAAATTGTAA","protein_sequence":"MPIKRLDTVVVNTGSQNDQHSASVPPVYLSTTFKVDLNNEDAQNYDYSRSGNPTRSVLQHQIGKLYRVPQENVLAVSSGMTALDVILRGLVLLNGTDNHTPTIIAGDDLYGGTQRLLNFFKQQSHAVSVHVDTSDFEKFKTVFQSLDKVDCVLLESPTNPLCKVVDIPRILRFVKCISPDTTVVVDNTMMSGLNCNPLQLNPGCDVVYESATKYLNGHHDLMGGVIISKTPEIASKLYFVINSTGAGLSPMDSWLLVRGLKTLGVRLYQQQRNAMILAHWLENSCGFKPTRTNKATKTRFVGLRSNPDFKLHKSFNNGPGAVLSFETGSFEHSKRLVSSKKLSIWAVTVSFGCVNSLLSMPCKMSHASIDPELRKERDFPEDLVRLCCGIENIVDLKKDLLAAMVDADIIEVRENGKYLFNKLNKNLAVNTTIDDLHKPLSIYEEFYNQDLIRKDSELNIKSSKL"},{"created_at":"2011-05-26T18:17:34.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"Putative cystathionine beta-lyase","uniprot_id":"P43623","uniprot_name":"METC_YEAST","enzyme":true,"transporter":false,"gene_name":"IRC7","num_residues":340,"molecular_weight":"36971.10156","theoretical_pi":"6.05","general_function":"Involved in pyridoxal phosphate binding","specific_function":"L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate","reactions":[{"id":1418,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2518,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate.","export":false,"pw_reaction_id":null,"source":null},{"id":3776,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006298","source":"Smpdb"},{"id":3777,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006777","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D50617","genbank_protein_id":"836697","gene_card_id":"IRC7","chromosome_location":"chromosome 6","locus":"YFR055W","synonyms":["CBL","Beta-cystathionase","Cysteine lyase","Increased recombination centers protein 7"],"enzyme_classes":["4.4.1.8"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" carbon-sulfur lyase activity"},{"category":"Function","description":" cystathionine beta-lyase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Sulfur metabolism","kegg_map_id":"00920"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGTCTACAGACAAGATCACATTTTTGTTGAACTGGCAACCAACCCCATACCATATTCCAATTTTCTTGGCTCAAACCAAAGGTTACTTCAAGGAGCAAGGTCTAGACATGGCCATCCTAGAACCAACCAATCCTTCCGATGTCACTGAGTTAATTGGATCTGGTAAGGTCGACATGGGTTTGAAAGCCATGATCCACACCTTGGCTGCCAAGGCCCGTGGTTTCCCAGTGACCTCTGTTGCCTCTTTGTTGGACGAACCATTTACCGGTGTCTTGTACTTAAAGGGCAGTGGTATCACTGAAGACTTCCAGTCCCTAAAGGGTAAGAAGATCGGTTACGTTGGTGAATTCGGTAAGATCCAAATCGATGAATTGACCAAGCACTACGGTATGAAGCCAGAAGACTACACCGCCGTCAGATGTGGTATGAATGTCGCCAAGTACATCATCGAAGGTAAGATTGATGCCGGTATTGGTATCGAATGTATGCAACAAGTCGAATTGGAAGAGTACTTGGCCAAGCAAGGCAGACCAGCTTCTGATGCTAAAATGTTGAGAATTGACAAGTTGGCTTGCTTGGGTTGCTGTTGCTTCTGTACCGTTCTTTACATCTGCAACGATGAATTTTTGAAGAAGAACCCTGAAAAGGTCAGAAAGTTCTTGAAAGCCATCAAGAAGGCAACCGACTACGTTCTAGCCGACCCTGTGAAGGCTTGGAAAGAATACATCGACTTCAAGCCTCAATTGAACAACGATCTATCCTACAAGCAATACCAAAGATGTTACGCTTACTTCTCTTCATCTTTGTACAATGTTCACCGTGACTGGAAGAAGGTTACCGGTTACGGTAAGAGATTAGCCATCTTGCCACCAGACTATGTCTCGAACTACACTAATGAATACTTGTCCTGGCCAGAACCAGAAGAGGTTTCTGATCCTTTGGAAGCTCAAAGATTGATGGCTATTCATCAAGAAAAATGCAGACAGGAAGGTACTTTCAAGAGATTGGCTCTTCCAGCTTAA","protein_sequence":"MIDRTELSKFGITTQLSVIGRNPDEQSGFVNPPLYKGSTIILKKLSDLEQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGTMEVQDIPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLIGLASANEECWPLLRSTYDAMAMLPGAEDCQLALRGMRTLHLRLKEVERKALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGFTRAGLEKMVEGMKVLQLGFSWGG"},{"created_at":"2011-05-27T02:00:30.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"Cystathionine beta-synthase","uniprot_id":"P32582","uniprot_name":"CBS_YEAST","enzyme":true,"transporter":false,"gene_name":"CYS4","num_residues":507,"molecular_weight":"56021.30078","theoretical_pi":"6.66","general_function":"Involved in cysteine biosynthetic process from serine","specific_function":"L-serine + L-homocysteine = L-cystathionine + H(2)O","reactions":[{"id":1419,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2655,"direction":"\u003e","locations":null,"altext":"L-serine + L-homocysteine = L-cystathionine + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":3778,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006299","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D16502","genbank_protein_id":"416161","gene_card_id":"CYS4","chromosome_location":"chromosome 7","locus":"YGR155W","synonyms":["Beta-thionase","Serine sulfhydrase","Sulfur transfer protein 4"],"enzyme_classes":["4.2.1.22"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Function","description":" hydro-lyase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" cystathionine beta-synthase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" serine family amino acid metabolic process"},{"category":"Process","description":" L-serine metabolic process"},{"category":"Process","description":" sulfur amino acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" sulfur amino acid biosynthetic process"},{"category":"Process","description":" cysteine biosynthetic process from serine"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cysteine biosynthetic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cysteine biosynthetic process via cystathionine"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"PALP","identifier":"PF00291"},{"name":"CBS","identifier":"PF00571"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGACTAAATCTGAGCAGCAAGCCGATTCAAGACATAACGTTATCGACTTAGTTGGTAACACCCCATTGATCGCACTGAAAAAATTGCCTAAGGCTTTGGGTATCAAACCACAAATTTATGCTAAGCTGGAACTATACAATCCAGGTGGTTCCATCAAAGACAGAATTGCCAAGTCTATGGTGGAAGAAGCTGAAGCTTCCGGTAGAATTCATCCTTCCAGATCTACTCTGATCGAACCTACTTCTGGTAACACCGGTATCGGTCTAGCTTTAATCGGCGCCATCAAAGGTTACAGAACTATCATCACCTTGCCGGAAAAAATGTCTAACGAGAAAGTTTCTGTCCTAAAGGCTCTGGGTGCTGAAATCATCAGAACTCCAACTGCTGCTGCCTGGGATTCTCCAGAATCACATATTGGTGTTGCTAAGAAGTTGGAAAAAGAGATTCCTGGTGCTGTTATACTTGACCAATATAACAATATGATGAACCCAGAAGCTCATTACTTTGGTACTGGTCGCGAAATCCAAAGACAGCTAGAAGACTTGAATTTATTTGATAATCTACGCGCTGTTGTTGCTGGTGCTGGTACTGGTGGGACTATTAGCGGTATTTCCAAGTACTTGAAAGAACAGAATGATAAGATCCAAATCGTTGGTGCTGACCCATTCGGTTCAATTTTAGCCCAACCTGAAAACTTGAATAAGACTGATATCACTGACTACAAAGTTGAGGGTATTGGTTATGATTTTGTTCCTCAGGTTTTGGACAGAAAATTAATTGATGTTTGGTATAAGACAGACGACAAGCCTTCTTTCAAATACGCCAGACAATTGATTTCTAACGAAGGTGTCTTGGTGGGTGGTTCTTCCGGTTCTACCTTCACTGCGGTTGTGAAATACTGTGAAGACCACCCTGAACTGACTGAAGATGATGTCATTGTTGCCATATTCCCAGATTCCATCAGGTCGTACCTAACCAAATTCGTCGATGACGAATGGTTGAAAAAGAACAATTTGTGGGATGATGACGTGTTGGCCCGTTTTGACTCTTCAAAGCTGGAGGCTTCGACGACAAAATACGCTGATGTGTTTGGTAACGCTACTGTAAAGGATCTTCACTTGAAACCGGTTGTTTCCGTTAAGGAAACCGCTAAGGTCACTGATGTTATCAAGATATTAAAAGACAATGGCTTTGACCAATTGCCTGTGTTGACTGAAGACGGCAAGTTGTCTGGTTTAGTTACTCTCTCTGAGCTTCTAAGAAAACTATCAATCAATAATTCAAACAACGACAACACTATAAAGGGTAAATACTTGGACTTCAAGAAATTAAACAATTTCAATGATGTTTCCTCTTACAACGAAAATAAATCCGGTAAGAAGAAGTTTATTAAATTCGATGAAAACTCAAAGCTATCTGACTTGAATCGTTTCTTTGAAAAAAACTCATCTGCCGTTATCACTGATGGCTTGAAACCAATCCATATCGTTACTAAGATGGATTTACTGAGCTACTTAGCATAA","protein_sequence":"MTKSEQQADSRHNVIDLVGNTPLIALKKLPKALGIKPQIYAKLELYNPGGSIKDRIAKSMVEEAEASGRIHPSRSTLIEPTSGNTGIGLALIGAIKGYRTIITLPEKMSNEKVSVLKALGAEIIRTPTAAAWDSPESHIGVAKKLEKEIPGAVILDQYNNMMNPEAHYFGTGREIQRQLEDLNLFDNLRAVVAGAGTGGTISGISKYLKEQNDKIQIVGADPFGSILAQPENLNKTDITDYKVEGIGYDFVPQVLDRKLIDVWYKTDDKPSFKYARQLISNEGVLVGGSSGSAFTAVVKYCEDHPELTEDDVIVAIFPDSIRSYLTKFVDDEWLKKNNLWDDDVLARFDSSKLEASTTKYADVFGNATVKDLHLKPVVSVKETAKVTDVIKILKDNGFDQLPVLTEDGKLSGLVTLSELLRKLSINNSNNDNTIKGKYLDFKKLNNFNDVSSYNENKSGKKKFIKFDENSKLSDLNRFFEKNSSAVITDGLKPIHIVTKMDLLSYLA"},{"created_at":"2011-05-27T03:41:09.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Homocysteine S-methyltransferase 1","uniprot_id":"Q12525","uniprot_name":"MHT1_YEAST","enzyme":true,"transporter":false,"gene_name":"MHT1","num_residues":324,"molecular_weight":"36714.5","theoretical_pi":"5.26","general_function":"Involved in homocysteine S-methyltransferase activity","specific_function":"Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S- methylmethionine (SMM) to methionine","reactions":[{"id":1637,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2739,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"S-methyl-L-methionine + L-homocysteine = 2 L-methionine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY558194","genbank_protein_id":"45270278","gene_card_id":"MHT1","chromosome_location":"chromosome 12","locus":"YLL062C","synonyms":["S-methylmethionine:homocysteine methyltransferase 1","SMM:Hcy S-methyltransferase 1"],"enzyme_classes":["2.1.1.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" S-methyltransferase activity"},{"category":"Function","description":" homocysteine S-methyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"S-methyl_trans","identifier":"PF02574"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"}],"gene_sequence":"ATGAAGCGCATTCCAATCAAAGAACTAATAGTTGAGCACCCCGGAAAAGTTCTTATCCTTGATGGTGGACAGGGTACAGAATTGGAAAACAGAGGCATTAACATAAATAGTCCGGTATGGTCTGCAGCTCCTTTTACGAGCGAATCCTTTTGGGAGCCATCTTCTCAAGAGCGAAAGGTGGTAGAAGAAATGTACAGAGACTTTATGATTGCTGGCGCAAACATATTAATGACAATTACTTACCAGGCAAACTTTCAAAGCATATCTGAGAATACCTCGATTAAAACTCTGGCTGCTTACAAGCGTTTTCTCGATAAAATCGTGTCATTTACTCGTGAATTTATTGGTGAGGAAAGGTACTTAATCGGGAGTATTGGCCCATGGGCAGCACATGTATCCTGTGAATATACTGGTGACTATGGTCCCCATCCTGAGAATATTGATTACTACGGCTTTTTCAAACCCCAGCTGGAGAACTTCAACCAAAATAGAGATATTGATCTTATTGGTTTTGAAACGATTCCAAATTTTCATGAGTTAAAGGCTATTTTATCCTGGGATGAAGATATTATTTCGAAGCCCTTTTATATTGGGTTGTCGGTGGATGACAATAGTTTGCTACGAGACGGTACCACTTTGGAAGAAATTTCTGTCCATATAAAAGGCCTCGGAAATAAAATTAACAAGAATCTCTTATTAATGGGAGTTAACTGTGTCAGTTTCAATCAATCGGCATTAATTCTTAAAATGTTGCACGAGCATCTACCTGGCATGCCTCTGCTAGTTTACCCAAACAGTGGAGAAATCTACAATCCCAAAGAGAAGACATGGCACCGGCCGACTAATAAGTTGGATGACTGGGAGACCACGGTTAAGAAATTCGTTGATAATGGTGCGCGCATTATTGGCGGTTGTTGTAGAACGTCTCCTAAAGATATCGCCGAAATTGCATCAGCTGTAGATAAATACTCCTAA","protein_sequence":"MKRIPIKELIVEHPGKVLILDGGQGTELENRGININSPVWSAAPFTSESFWEPSSQERKVVEEMYRDFMIAGANILMTITYQANFQSISENTSIKTLAAYKRFLDKIVSFTREFIGEERYLIGSIGPWAAHVSCEYTGDYGPHPENIDYYGFFKPQLENFNQNRDIDLIGFETIPNFHELKAILSWDEDIISKPFYIGLSVDDNSLLRDGTTLEEISVHIKGLGNKINKNLLLMGVNCVSFNQSALILKMLHEHLPGMPLLVYPNSGEIYNPKEKTWHRPTNKLDDWETTVKKFVDNGARIIGGCCRTSPKDIAEIASAVDKYS"},{"created_at":"2011-05-27T03:42:09.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Homocysteine S-methyltransferase 2","uniprot_id":"Q08985","uniprot_name":"SAM4_YEAST","enzyme":true,"transporter":false,"gene_name":"SAM4","num_residues":325,"molecular_weight":"36668.19922","theoretical_pi":"4.88","general_function":"Involved in homocysteine S-methyltransferase activity","specific_function":"Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S- methylmethionine (SMM) to methionine","reactions":[{"id":1637,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2739,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"S-methyl-L-methionine + L-homocysteine = 2 L-methionine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"Z73629","genbank_protein_id":"1370563","gene_card_id":"SAM4","chromosome_location":"chromosome 16","locus":"YPL273W","synonyms":["S-adenosylmethionine metabolism protein 4","S-methylmethionine:homocysteine methyltransferase 2","SMM:Hcy S-methyltransferase 2"],"enzyme_classes":["2.1.1.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" S-methyltransferase activity"},{"category":"Function","description":" homocysteine S-methyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"S-methyl_trans","identifier":"PF02574"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"}],"gene_sequence":"ATGGCACGTCTTCCTCTAAAGCAGTTCTTAGCGGATAACCCCAAAAAAGTTCTTGTTCTTGACGGTGGTCAAGGAACAGAACTGGAAAACAGAGGTATCAAAGTTGCAAATCCCGTGTGGTCTACTATTCCATTTATTAGCGAATCATTTTGGTCTGATGAGTCATCTGCTAACAGAAAAATTGTCAAAGAAATGTTCAACGATTTCTTGAATGCTGGCGCAGAAATATTGATGACTACAACATACCAAACGAGTTATAAATCAGTTTCTGAAAACACCCCAATCAGAACTTTATCCGAGTACAATAACCTTTTAAACAGGATTGTCGATTTTTCTCGTAATTGTATTGGCGAAGACAAATATTTGATTGGCTGTATTGGCCCATGGGGTGCTCATATTTGTCGTGAGTTTACAGGCGACTATGGTGCTGAGCCAGAAAATATTGATTTCTACCAATACTTCAAGCCTCAGTTGGAGAATTTCAATAAAAATGACAAATTGGATTTGATTGGGTTTGAAACCATTCCTAACATCCATGAACTGAAAGCTATCTTATCTTGGGATGAGAGTATCCTGTCTAGACCCTTCTATATCGGGTTGTCTGTGCATGAGCACGGTGTCTTGAGAGACGGCACTACCATGGAAGAAATCGCACAAGTTATTAAGGACTTGGGCGACAAAATAAATCCTAACTTCTCGTTCTTAGGAATCAACTGCGTCAGCTTCAACCAATCACCCGACATTCTTGAGTCTCTACATCAAGCACTACCAAATATGGCCTTGCTTGCTTATCCAAACAGTGGTGAAGTTTATGATACTGAAAAGAAGATATGGTTGCCAAATAGCGATAAGCTGAACAGTTGGGATACGGTTGTTAAACAGTACATTAGCAGCGGTGCCCGTATCATTGGTGGTTGTTGCAGAACAAGTCCAAAAGACATCCAAGAGATTTCTGCAGCCGTCAAGAAATACACGTAA","protein_sequence":"MARLPLKQFLADNPKKVLVLDGGQGTELENRGIKVANPVWSTIPFISESFWSDESSANRKIVKEMFNDFLNAGAEILMTTTYQTSYKSVSENTPIRTLSEYNNLLNRIVDFSRNCIGEDKYLIGCIGPWGAHICREFTGDYGAEPENIDFYQYFKPQLENFNKNDKLDLIGFETIPNIHELKAILSWDESILSRPFYIGLSVHEHGVLRDGTTMEEIAQVIKDLGDKINPNFSFLGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNSDKLNSWDTVVKQYISSGARIIGGCCRTSPKDIQEISAAVKKYT"}]}