{"ymdb_id":"YMDB00318","created_at":"2011-05-29T18:05:44.000Z","updated_at":"2016-10-18T17:11:26.000Z","name":"L-Methionine","cas":"63-68-3","state":"Solid","melting_point":"284 oC","description":"Methionine (abbreviated as Met or M) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a nonpolar amino acid, because of the hydrophobic nature of the thioether-alkyl side chain. Together with cysteine, methionine is one of two sulfur-containing proteinogenic amino acids. Its derivative S-adenosyl methionine (SAM) serves as a methyl donor. Methionine is an intermediate in the biosynthesis of cysteine, carnitine, taurine, lecithin, phosphatidylcholine, and other phospholipids. Methionine is synthesized via a pathway that uses both aspartic acid and cysteine. First, aspartic acid is converted via β-aspartyl-semialdehyde into homoserine, introducing the pair of contiguous methylene groups. Homoserine converts to O-succinyl homoserine, which then reacts with cysteine to produce cystathionine, which is cleaved to yield homocysteine. Subsequent methylation of the thiol group by folates affords methionine. The principal fates methionine are incorporation into polypeptide chains, and use in the production of alpha-ketobutyrate and cysteine via SAM (S-adenosylmethionine). The transulfuration reactions that produce cysteine from homocysteine and serine also produce alpha-ketobutyrate, the latter being converted first to propionyl-CoA and then via a 3-step process to succinyl-CoA.","experimental_water_solubility":"56.6 mg/mL at 25 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"-1.87 [HANSCH,C ET AL. (1995)]","location":"extracellular;mitochondrion;cytoplasm","synthesis_reference":"Boy, Matthias; Klein, Daniela; Schroeder, Hartwig.  Method for the production and recovery of methionine.    PCT Int. Appl.  (2005),     34 pp.","chebi_id":"16643","hmdb_id":"HMDB00696","kegg_id":"C00073","pubchem_id":"6137","cs_id":"5907","foodb_id":null,"wikipedia_link":"Methionine","biocyc_id":"MET","iupac":"(2S)-2-amino-4-(methylsulfanyl)butanoic acid","traditional_iupac":"L-methionine","logp":"-2.189326616871282","pka":null,"alogps_solubility":"2.39e+01 g/l","alogps_logp":"-1.85","alogps_logs":"-0.80","acceptor_count":"3","donor_count":"2","rotatable_bond_count":"4","polar_surface_area":"63.31999999999999","refractivity":"37.586000000000006","polarizability":"15.504513637142049","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.502323343916569","pka_strongest_acidic":"2.5319210041042344","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2S)-2-amino-4-(methylsulfanyl)butanoate","(2S)-2-amino-4-(methylsulfanyl)butanoic acid","(l)-methionine","(s)-(+)-methionine","(S)-2-amino-4-(methylthio)-Butanoate","(S)-2-amino-4-(methylthio)-Butanoic acid","(S)-2-Amino-4-(methylthio)butanoate","(S)-2-Amino-4-(methylthio)butanoic acid","(S)-2-amino-4-(methylthio)butyric acid","(s)-methionine","2-Amino-4-(methylthio)butyrate","2-Amino-4-(methylthio)butyric acid","2-Amino-4-methylthiobutanoate","2-Amino-4-methylthiobutanoic acid","A-amino-g-methylmercaptobutyrate","A-amino-g-methylmercaptobutyric acid","Acimethin","alpha-amino-alpha-aminobutyric acid","alpha-amino-gamma-methylmercaptobutyrate","Alpha-amino-gamma-methylmercaptobutyric acid","Cymethion","G-methylthio-a-aminobutyrate","G-methylthio-a-aminobutyric acid","gamma-methylthio-alpha-aminobutyrate","gamma-methylthio-alpha-aminobutyric acid","H-met-h","H-met-oh","L-(-)-methionine","l-2-Amino-4-(methylthio)butyric acid","L-2-Amino-4methylthiobutyric acid","L-a-amino-g-methylthiobutyrate","L-a-amino-g-methylthiobutyric acid","L-alpha-amino-gamma-methylmercaptobutyric acid","L-alpha-amino-gamma-methylthiobutyrate","L-alpha-amino-gamma-methylthiobutyric acid","L-gamma-methylthio-alpha-aminobutyric acid","L-methionin","L-Methionine","L-methioninum","L(-)-amino-alpha-amino-alpha-aminobutyric acid","L(-)-amino-gamma-methylthiobutyric acid","Liquimeth","Mepron","MET","Methilanin","Methionine","Methioninum","Metionina","Neo-methidin","Poly-l-methionine","Polymethionine","S-methionine","S-methyl-l-homocysteine"],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Biotin Biosynthesis","kegg_map_id":null},{"name":"Lipoic acid metabolism","kegg_map_id":"00785"},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"One Carbon Pool by Folate I","kegg_map_id":null}],"growth_conditions":[{"growth_media":"YPD media","concentration":"343.8359","concentration_units":"\u0026#181;M","error":"6.84103"},{"growth_media":"YPG media","concentration":"343.8359","concentration_units":"\u0026#181;M","error":"6.84103"},{"growth_media":"SD media","concentration":"68.70769","concentration_units":"\u0026#181;M","error":"1.48718"},{"growth_media":"SG media","concentration":"68.70769","concentration_units":"\u0026#181;M","error":"1.48718"},{"growth_media":"M (molasses)","concentration":"274.83077","concentration_units":"\u0026#181;M","error":"5.35385"},{"growth_media":"MA (molasses)","concentration":"137.41538","concentration_units":"\u0026#181;M","error":"2.67692"},{"growth_media":"MB (molasses)","concentration":"68.70769","concentration_units":"\u0026#181;M","error":"1.48718"},{"growth_media":"MAB (molasses)","concentration":"137.41538","concentration_units":"\u0026#181;M","error":"2.67692"},{"growth_media":"YEB media with 0.5 mM glucose","concentration":"592.0","concentration_units":"\u0026#181;M","error":"30.0"},{"growth_media":"Synthetic medium with 20 g/L glucose","concentration":"160.0","concentration_units":"\u0026#181;M","error":"34.0"},{"growth_media":"Glucose limited aerobic culture","concentration":"0.2","concentration_units":"umol/g DW","error":"0.0"}],"references":[{"pubmed_id":7654310,"citation":"Martinez-Force, E., Benitez, T. (1995). \"Effects of varying media, temperature, and growth rates on the intracellular concentrations of yeast amino acids.\" Biotechnol Prog 11:386-392."},{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":11154694,"citation":"White, W. H., Gunyuzlu, P. L., Toyn, J. H. (2001). \"Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine.\" J Biol Chem 276:10794-10800."},{"pubmed_id":5764336,"citation":"Cherest, H., Eichler, F., Robichon-Szulmajster, H. (1969). \"Genetic and regulatory aspects of methionine biosynthesis in Saccharomyces cerevisiae.\" J Bacteriol 97:328-336."},{"pubmed_id":18625006,"citation":"Pirkov, I., Norbeck, J., Gustafsson, L., Albers, E. (2008). \"A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.\" FEBS J 275:4111-4120."},{"pubmed_id":12584756,"citation":"Hans, M. A., Heinzle, E., Wittmann, C. (2003). \"Free intracellular amino acid pools during autonomous oscillations in Saccharomyces cerevisiae.\" Biotechnol Bioeng 82:143-151."},{"pubmed_id":15042590,"citation":"Mulet, J. M., Alemany, B., Ros, R., Calvete, J. J., Serrano, R. (2004). \"Expression of a plant serine O-acetyltransferase in Saccharomyces cerevisiae confers osmotic tolerance and creates an alternative pathway for cysteine biosynthesis.\" Yeast 21:303-312."},{"pubmed_id":194884,"citation":"Chiang, P. K., Cantoni, G. L. (1977). \"Activation of methionine for transmethylation. Purification of the S-adenosylmethionine synthetase of bakers' yeast and its separation into two forms.\" J Biol Chem 252:4506-4513."},{"pubmed_id":18687109,"citation":"Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). \"The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism.\" BMC Syst Biol 2:71."},{"pubmed_id":16083849,"citation":"Suliman, H. S., Sawyer, G. M., Appling, D. R., Robertus, J. D. (2005). \"Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae.\" Arch Biochem Biophys 441:56-63."},{"pubmed_id":11013242,"citation":"Thomas, D., Becker, A., Surdin-Kerjan, Y. (2000). \"Reverse methionine biosynthesis from S-adenosylmethionine in eukaryotic cells.\" J Biol Chem 275:40718-40724."},{"pubmed_id":3542720,"citation":"Csaikl, U., Csaikl, F. (1986). \"Molecular cloning and characterization of the MET6 gene of Saccharomyces cerevisiae.\" Gene 46:207-214."}],"proteins":[{"created_at":"2011-05-24T19:37:34.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"General amino-acid permease GAP1","uniprot_id":"P19145","uniprot_name":"GAP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GAP1","num_residues":602,"molecular_weight":"65654.89844","theoretical_pi":"8.67","general_function":"Involved in transport","specific_function":"Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;122-142;166-185;205-224;238-256;281-298;322-342;377-396;422-442;452-472;492-510;530-548","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY723840","genbank_protein_id":"51830440","gene_card_id":"GAP1","chromosome_location":"chromosome 11","locus":"YKR039W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAGTAATACTTCTTCGTACGAGAAGAATAATCCAGATAATCTGAAACACAATGGTATTACCATAGATTCTGAGTTTCTAACTCAGGAGCCAATAACCATTCCCTCAAATGGCTCCGCTGTTTCTATTGACGAAACAGGTTCAGGGTCCAAATGGCAAGACTTTAAAGATTCTTTCAAAAGGGTAAAACCTATTGAAGTTGATCCTAATCTTTCAGAAGCTGAAAAAGTGGCTATCATCACTGCCCAAACTCCATTGAAGCACCACTTGAAGAATAGACATTTGCAAATGATTGCCATCGGTGGTGCCATCGGTACTGGTCTGCTGGTTGGGTCAGGTACTGCACTAAGAACAGGTGGTCCCGCTTCGCTACTGATTGGATGGGGGTCTACAGGTACCATGATTTACGCTATGGTTATGGCTCTGGGTGAGTTGGCTGTTATCTTCCCTATTTCGGGTGGGTTCACCACGTACGCTACCAGATTTATTGATGAGTCCTTTGGTTACGCTAATAATTTCAATTATATGTTACAATGGTTGGTTGTGCTACCATTGGAAATTGTCTCTGCATCTATTACTGTAAATTTCTGGGGTACAGATCCAAAGTATAGAGATGGGTTTGTTGCGTTGTTTTGGCTTGCAATTGTTATCATCAATATGTTTGGTGTCAAAGGTTATGGTGAAGCAGAATTCGTCTTTTCATTTATCAAGGTCATCACTGTTGTTGGGTTCATCATCTTAGGTATCATTCTAAACTGTGGTGGTGGTCCAACAGGTGGTTACATTGGGGGCAAGTACTGGCATGATCCTGGTGCCTTTGCTGGTGACACTCCAGGTGCTAAATTCAAAGGTGTTTGTTCTGTCTTCGTCACCGCTGCCTTTTCTTTTGCCGGTTCAGAATTGGTTGGTCTTGCTGCCAGTGAATCCGTAGAGCCTAGAAAGTCCGTTCCTAAGGCTGCTAAACAAGTTTTCTGGAGAATCACCCTATTTTATATTCTGTCGCTATTAATGATTGGTCTTTTAGTCCCATACAACGATAAAAGTTTGATTGGTGCCTCCTCTGTGGATGCTGCTGCTTCACCCTTCGTCATTGCCATTAAGACTCACGGTATCAAGGGTTTGCCAAGTGTTGTCAACGTCGTTATCTTGATTGCCGTGTTATCTGTCGGTAACTCTGCCATTTATGCATGTTCCAGAACAATGGTTGCCCTAGCTGAACAGAGATTTCTGCCAGAAATCTTTTCCTACGTTGACCGTAAGGGTAGACCATTGGTGGGAATTGCTGTCACATCTGCATTCGGTCTTATTGCGTTTGTTGCCGCCTCCAAAAAGGAAGGTGAAGTTTTCAACTGGTTACTAGCCTTGTCTGGGTTGTCATCTCTATTCACATGGGGTGGTATCTGTATTTGTCACATTCGTTTCAGAAAGGCATTGGCCGCCCAAGGAAGAGGCTTGGATGAATTGTCTTTCAAGTCTCCTACCGGTGTTTGGGGTTCCTACTGGGGGTTATTTATGGTTATTATTATGTTCATTGCCCAATTCTACGTTGCCGTATTCCCCGTGGGAGATTCTCCAAGTGCGGAAGGTTTCTTCGAAGCTTATCTATCCTTCCCACTTGTTATGGTTATGTACATCGGACACAAGATCTATAAGAGGAATTGGAAGCTTTTCATCCCAGCAGAAAAGATGGACATTGATACGGGTAGAAGAGAAGTCGATTTAGATTTGTTGAAACAAGAAATTGCAGAAGAAAAGGCAATTATGGCCACAAAGCCAAGATGGTATAGAATCTGGAATTTCTGGTGTTAA","protein_sequence":"MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC"},{"created_at":"2011-05-24T19:38:06.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"High-affinity glutamine permease","uniprot_id":"P48813","uniprot_name":"GNP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GNP1","num_residues":663,"molecular_weight":"73597.39844","theoretical_pi":"7.8","general_function":"Involved in transport","specific_function":"High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn","reactions":[],"signal_regions":"None","transmembrane_regions":"155-175;178-198;220-240;265-285;290-310;343-363;382-402;433-453;482-502;507-527;561-581;591-611","pdb_id":null,"cellular_location":"Mitochondrion membrane; Multi-pass membrane protein","genbank_gene_id":"U21643","genbank_protein_id":"833812","gene_card_id":"GNP1","chromosome_location":"chromosome 4","locus":"YDR508C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGACGCTTGGTAATAGACGCCATGGGCGGAATAATGAGGGAAGCTCTAATATGAATATGAATCGTAACGACCTTGACGATGTTTCCCATTACGAGATGAAGGAAATACAACCAAAGGAAAAACAAATTGGCTCTATAGAACCGGAAAATGAAGTAGAATATTTTGAAAAAACAGTGGAAAAAACCATTGAAAATATGGAATATGAAGGTGAACATCATGCATCTTACTTACGGAGGTTCATTGACTCGTTTAGAAGAGCGGAAGGCTCGCATGCAAATTCCCCAGACTCGAGCAACTCTAATGGGACTACTCCTATATCCACAAAAGATTCCAGCTCTCAATTGGACAATGAGTTGAATCGGAAGAGCTCATACATCACTGTTGATGGTATTAAACAGTCACCACAAGAACAAGAACAGAAACAAGAAAATTTGAAAAAGAGTATAAAGCCCCGTCATACGGTGATGATGTCCCTAGGGACTGGTATTGGTACTGGTTTGCTGGTCGGTAACTCCAAAGTTTTGAACAATGCAGGTCCGGGTGGTTTGATCATTGGTTATGCTATTATGGGTAGTTGTGTTTACTGTATTATTCAAGCTTGTGGTGAATTAGCGGTTATATACAGTGATTTGATTGGTGGATTTAATACATATCCTTTGTTTTTGGTCGACCCTGCACTTGGCTTTTCTGTTGCTTGGCTTTTTTGCTTACAATGGCTATGTGTTTGTCCTCTAGAATTGGTCACTGCATCCATGACTATCAAATATTGGACGACATCTGTGAACCCGGATGTTTTCGTTGTTATCTTCTACGTACTAATCGTTGTTATCAACGTTTTTGGAGCTAAGGGTTATGCAGAGGCAGATTTCTTCTTCAATTGTTGTAAAATTCTGATGATAGTTGGATTTTTCATTCTCGCCATTATTATTGATTGTGGTGGTGCAGGTACCGATAGTTACATAGGTAGCAAATATTGGCGTGATCCCGGAGCCTTCCGTGGTGATACACCCATCCAGAGGTTCAAAGGTGTCGTTGCCACATTTGTCACAGCAGCGTTCGCCTTTGGTATGAGTGAACAGCTGGCTATGACTGCCAGTGAACAATCCAATCCAAGAAAGGCTATTCCATCGGCGGCAAAGAAAATGATTTATAGAATTCTGTTTGTGTTCTTGGCGTCTTTAACGTTAGTTGGTTTCCTTGTACCTTACACCTCAGATCAATTGCTAGGGGCCGCAGGTTCAGCCACTAAAGCGTCGCCCTACGTCATCGCTGTCTCCTCTCATGGTGTTCGTGTGGTTCCTCATTTCATAAACGCTGTCATCCTGTTGTCTGTTCTTTCCGTTGCTAACGGTGCCTTCTATACCAGTTCTCGTATTTTGATGTCGTTGGCCAAACAAGGTAATGCACCCAAATGTTTCGATTACATCGATAGGGAAGGTAGACCTGCTGCTGCTATGCTTGTCAGTGCATTATTTGGTGTCATTGCATTCTGTGCCTCATCTAAAAAGGAAGAGGACGTTTTCACCTGGTTGTTAGCAATCTCCGGTTTGTCTCAATTATTCACGTGGATTACCATTTGTTTGTCTCACATTAGGTTTAGAAGAGCTATGAAAGTGCAAGGAAGGTCCTTAGGAGAGGTTGGTTATAAATCTCAAGTCGGTGTCTGGGGGTCGGCTTACGCTGTCCTTATGATGGTGTTAGCTTTAATCGCCCAATTTTGGGTTGCCATTGCCCCAATTGGTGGAGGAGGTAAGTTAAGTGCCCAATCATTTTTTGAGAATTATTTGGCTATGCCAATCTGGATTGCTTTATACATCTTTTACAAAGTTTGGAAAAAAGATTGGAGTTTATTCATTCCCGCTGATAAAGTAGACTTAGTTTCTCATAGAAACATCTTTGATGAAGAATTATTAAAACAAGAAGATGAAGAATATAAAGAGAGATTAAGAAACGGACCATACTGGAAAAGAGTTCTTGATTTCTGGTGTTAA","protein_sequence":"MTLGNRRHGRNNEGSSNMNMNRNDLDDVSHYEMKEIQPKEKQIGSIEPENEVEYFEKTVEKTIENMEYEGEHHASYLRRFIDSFRRAEGSHANSPDSSNSNGTTPISTKDSSSQLDNELNRKSSYITVDGIKQSPQEQEQKQENLKKSIKPRHTVMMSLGTGIGTGLLVGNSKVLNNAGPGGLIIGYAIMGSCVYCIIQACGELAVIYSDLIGGFNTYPLFLVDPALGFSVAWLFCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVVIFYVLIVVINVFGAKGYAEADFFFNCCKILMIVGFFILAIIIDCGGAGTDGYIGSKYWRDPGAFRGDTPIQRFKGVVATFVTAAFAFGMSEQLAMTASEQSNPRKAIPSAAKKMIYRILFVFLASLTLVGFLVPYTSDQLLGAAGSATKASPYVIAVSSHGVRVVPHFINAVILLSVLSVANGAFYTSSRILMSLAKQGNAPKCFDYIDREGRPAAAMLVSALFGVIAFCASSKKEEDVFTWLLAISGLSQLFTWITICLSHIRFRRAMKVQGRSLGEVGYKSQVGVWGSAYAVLMMVLALIAQFWVAIAPIGGGGKLSAQSFFENYLAMPIWIALYIFYKVWKKDWSLFIPADKVDLVSHRNIFDEELLKQEDEEYKERLRNGPYWKRVLDFWC"},{"created_at":"2011-05-24T20:58:27.000Z","updated_at":"2011-05-24T20:58:27.000Z","name":"Free methionine-R-sulfoxide reductase","uniprot_id":"P36088","uniprot_name":"FRMSR_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":180,"molecular_weight":"19734.19922","theoretical_pi":"4.69","general_function":"Involved in protein binding","specific_function":"Catalyzes the reversible oxidation-reduction of the R- enantiomer of free methionine sulfoxide to methionine. Does not act on S-enantiomer of free methionine sulfoxide or R-enantiomer of dabsylated methionine sulfoxide. Involved in protection against oxidative stress","reactions":[{"id":2353,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"L-methionine + thioredoxin disulfide + H(2)O = L-methionine (R)-S-oxide + thioredoxin.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1F5M","cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"X75780","genbank_protein_id":"433630","gene_card_id":null,"chromosome_location":null,"locus":"YKL069W","synonyms":["fRMsr","GAF domain-containing protein YKL069W"],"enzyme_classes":["1.8.4.14"],"go_classes":[],"pfams":[{"name":"GAF","identifier":"PF01590"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"}],"gene_sequence":"ATGGGCTCATCAACCGGGTTTCATCATGCCGATCATGTTAACTATTCTTCAAATCTGAATAAGGAAGAAATTCTAGAACAGCTTCTGCTTTCATACGAGGGGCTATCAGATGGACAAGTCAATTGGGTTTGTAATTTGTCAAACGCTTCGTCATTGATCTGGCATGCGTACAAGTCATTAGCTGTTGATATCAATTGGGCTGGATTTTACGTTACTCAAGCTAGCGAAGAAAACACACTGATATTGGGCCCATTTCAAGGAAAGGTCGCTTGCCAAATGATTCAATTCGGTAAAGGTGTTTGCGGAACTGCAGCCTCTACAAAGGAAACGCAGATTGTTCCAGATGTCAACAAGTATCCCGGTCATATTGCGTGCGACGGTGAAACCAAGAGCGAAATTGTTGTTCCAATCATATCCAATGATGGTAAGACATTGGGCGTCATAGACATAGATTGTTTGGATTACGAAGGATTCGACCACGTAGACAAAGAATTCCTAGAAAAACTTGCTAAATTAATTAATAAATCATGTGTCTTTAAATAA","protein_sequence":"MGSSTGFHHADHVNYSSNLNKEEILEQLLLSYEGLSDGQVNWVCNLSNASSLIWHAYKSLAVDINWAGFYVTQASEENTLILGPFQGKVACQMIQFGKGVCGTAASTKETQIVPDVNKYPGHIACDGETKSEIVVPIISNDGKTLGVIDIDCLDYEGFDHVDKEFLEKLAKLINKSCVFK"},{"created_at":"2011-05-24T21:03:21.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Leu/Val/Ile amino-acid permease","uniprot_id":"P38084","uniprot_name":"BAP2_YEAST","enzyme":false,"transporter":true,"gene_name":"BAP2","num_residues":609,"molecular_weight":"67669.60156","theoretical_pi":"8.22","general_function":"Involved in transport","specific_function":"Permease for leucine, valine and isoleucine. Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan","reactions":[],"signal_regions":"None","transmembrane_regions":"100-120;124-144;174-194;211-231;236-256;290-310;329-349;375-395;428-448;452-472;501-521;537-557","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"Z35937","genbank_protein_id":"536316","gene_card_id":"BAP2","chromosome_location":"chromosome 2","locus":"YBR068C","synonyms":["Branched-chain amino-acid permease 2"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGCTATCTTCAGAAGATTTTGGATCTTCTGGGAAAAAGGAAACTTCTCCTGATTCGATATCGATACGTTCCTTTAGTGCCGGGAATAATTTCCAATCATCATCAAGTGAGAAAACTTATTCTAAGCAAAAATCCGGGAGTGACAAACTTATACATAGATTTGCGGATTCATTCAAAAGAGCCGAGGGTAGCACTACAAGAACTAAGCAAATAAATGAAAATACGTCTGATTTAGAGGATGGCGTTGAGTCTATCACGTCGGATTCCAAGTTGAAAAAGTCCATGAAGTCGCGCCATGTTGTCATGATGTCTTTAGGGACAGGTATTGGGACTGGTCTTTTGGTAGCTAATGCAAAAGGTCTACATTACGGTGGTCCTGCTGCGCTAATAATTGGTTACATCTTGGTTTCTTTCGAGACGTACTTCATGATCCAAGCTGCAGGTGAGATGGCGGTAACCTATCCGACTTTACCAGCAAATTTCAACGCATACTCCTCCATATTCATTTCCAAATCATTTGGATTCGCCACAGTATGGCTTTACTGTTTCCAATGGCTAACGGTTTTGCCTTTAGAGTTAATAACCGCGTCTATGACTATTCAATTTGGGAATGATAAAATAAATCCGGACATTTATATTCTTATTTTCTATGTTTTCTTAGTATTCATTCATTTCTTCGGTGTAAAAGCCTATGGTGAAACGGAATTCATCTTCAATTGCTGTAAAATTTTAATGATTGCAGGTTTCATTATTCTTTCTATTGTTATCAACTGTGGTGGGGCCGGAAATGACGGTTATATCGGGGCCACTTATTGGCATAATCCAGGTGCTTTTGCAGGTGACACATCGATTGGTAGGTTCAAAAACGTTTGCTATATTTTAGTTACTGCTTACTTCTCCTTTGGTGGTATGGAATTATTTGCACTAAGTGTTCAGGAACAGTCTAACCCTAGAAAATCTACTCCGGTGGCAGCCAAGAGAAGCATTTATCGTATCGTTGTGATTTATCTTTTGACTATGATCCTCATTGGATTCAATGTTCCATATAATGATGACCAACTAATGGGCGCAGGCGGATCCGCTACACATGCATCTCCCTATGTCTTAGCCGCTTCTATTCACGGTGTGAAAATTGTTCCACATATTATCAACGCTGTTATTTTGATTTCTGTGGTTTCAGTGGCAAATTCCTCTTTGTATGCTGGTCCAAGACTGATTTGCTCTTTGGCCCAACAAGGCTACGCACCCAAGTTTTTAGATTACGTTGACAGAGAGGGCAGGCCCTTGAGAGCTCTTATTGTGTGTTGCGTTTTCGGCGTCATTGCTTTTGTTGCAGCTTCATCAAAGGAAGAGATCGTGTTTACATGGTTAGCAGCTATCGCAGGCTTGAGTGAATTATTCACATGGACTTCCATAATGTTGTCCCATCTGCGATTCAGACAAGCAATGAAAGTACAGGGAAGGTCTCTAGACGAGTTGGGATACAAGGCCACAACAGGGATTTGGGGTTCCATATACGGTGTCTTTTTTAATATTTTAGTCTTTGTTGCCCAATTTTGGGTAGCATTGGCCCCCTTAGGTAATGGGGGCAAATGCGATGCGGAATCCTTCTTTCAAAATTATTTAGCTTTTCCAATATGGTTGGCCTTTTACTTCGGATATATGGTTTACAACCGAGATTTTACGCTATTAAATCCCCTCGACAAGATTGACCTTGACTTCCACAGACGCATTTATGATCCAGAGCTAATGAGACAAGAGGACGAAGAAAATAAAGAAAAACTAAGGAATATGTCTTTGATGAGAAAAGCTTATCATTTCTGGTGTTAA","protein_sequence":"MLSSEDFGSSGKKETSPDSISIRSFSAGNNFQSSSSEKTYSKQKSGSDKLIHRFADSFKRAEGSTTRTKQINENTSDLEDGVESITSDSKLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLHYGGPAALIIGYILVSFETYFMIQAAGEMAVTYPTLPANFNAYSSIFISKSFGFATVWLYCFQWLTVLPLELITASMTIQFGNDKINPDIYILIFYVFLVFIHFFGVKAYGETEFIFNCCKILMIAGFIILSIVINCGGAGNDGYIGATYWHNPGAFAGDTSIGRFKNVCYILVTAYFSFGGMELFALSVQEQSNPRKSTPVAAKRSIYRIVVIYLLTMILIGFNVPYNDDQLMGAGGSATHASPYVLAASIHGVKIVPHIINAVILISVVSVANSSLYAGPRLICSLAQQGYAPKFLDYVDREGRPLRALIVCCVFGVIAFVAASSKEEIVFTWLAAIAGLSELFTWTSIMLSHLRFRQAMKVQGRSLDELGYKATTGIWGSIYGVFFNILVFVAQFWVALAPLGNGGKCDAESFFQNYLAFPIWLAFYFGYMVYNRDFTLLNPLDKIDLDFHRRIYDPELMRQEDEENKEKLRNMSLMRKAYHFWC"},{"created_at":"2011-05-24T21:05:56.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Valine amino-acid permease","uniprot_id":"P41815","uniprot_name":"BAP3_YEAST","enzyme":false,"transporter":true,"gene_name":"BAP3","num_residues":604,"molecular_weight":"67364.39844","theoretical_pi":"8.28","general_function":"Involved in transport","specific_function":"Involved in transport of isoleucine, leucine, valine, cysteine, methionine, phenylalanine, tyrosine and tryptophan","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;120-140;170-190;207-227;239-259;285-305;324-344;378-398;424-444;450-470;503-523;532-552","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"Z49209","genbank_protein_id":"798899","gene_card_id":"BAP3","chromosome_location":"chromosome 4","locus":"YDR046C","synonyms":["Branched-chain amino-acid permease 3"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGTCAGATCCTATAGTAACGTCTTCCAAAATGGAAAAAAGTGCAGAGTTTGAAGTAACAGACTCTGCTTTATATAATAACTTCAATACATCAACAACAGCTTCACTAACTCCGGAGATTAAGGAACATTCTGAGGAATCTCGCAATGGGTTAGTTCACAGATTCGTCGACTCATTCAGAAGAGCCGAAAGCCAACGTTTAGAAGAAGACAATGACTTGGAGGATGGTACCAAATCGATGAAATCTAATAACCACTTAAAAAAGTCAATGAAATCTAGACATGTTGTAATGATGTCTTTAGGTACAGGGATAGGAACAGGTCTTCTAGTTGCCAACGCCAAAGGTTTGAGTCTTGCAGGCCCGGGGTCTTTAGTCATCGGTTACGTTATGGTGTCCTTCGTCACGTATTTTATGGTCCAAGCGGCTGGTGAGATGGGTGTCACTTATCCGACGCTTCCAGGTAACTTCAATGCATACAATTCAATCTTTATTTCAAAGTCGTTTGGGTTCGCGACCACTTGGTTATTTTGCATTCAGTGGTTAACTGTGCTACCGTTGGAATTGATTACTTCTTCCATGACCGTCAAGTACTGGAATGACACAATTAATGCTGATGTATTCATTGTCATTTTCTATGTGTTTTTATTGTTTATCCACTTTTTTGGTGTTAAGGCATACGGTGAAACGGAATTTATCTTCAATTCCTGTAAGATATTGATGGTTGCAGGATTCATTATTTTATCAGTCGTCATCAATTGTGGGGGAGCCGGTGTGGACGGCTATATTGGCGGCAAATATTGGCGCGACCCTGGTTCATTTGCAGAAGGCAGCGGTGCCACTCGTTTCAAAGGGATATGTTATATTCTAGTATCTGCATATTTCTCCTTCGGTGGTATTGAATTATTTGTTCTTTCCATCAATGAGCAGTCTAACCCTAGAAAATCCACTCCTGTAGCCGCGAAGAGAAGTGTATATCGTATTTTGATCATTTATTTGCTGACAATGATTCTAATTGGGTTCAATGTTCCTCACAATAACGATCAATTGATGGGTTCCGGTGGCTCCGCAACGCACGCTTCACCATATGTCTTGGCAGCCTCTATTCACAAGGTTAGGGTCATCCCCCATATCATTAATGCTGTTATTTTGATATCAGTCATCTCTGTTGCGAACTCTGCCCTTTATGCCGCACCGAGATTAATGTGTTCCTTGGCTCAACAGGGCTATGCTCCAAAATTTTTGAACTATATTGATAGGGAGGGAAGACCTTTAAGGGCCTTGGTAGTGTGCTCTCTTGTTGGTGTCGTTGGCTTCGTCGCCTGTTCTCCACAGGAAGAGCAAGCATTTACATGGTTGGCAGCCATTGCAGGTTTGAGTGAACTTTTCACATGGTCAGGCATTATGCTTTCACACATTCGATTCAGAAAAGCGATGAAAGTCCAAGGAAGATCACTTGATGAAGTCGGCTATAAGGCCAATACCGGTATATGGGGTTCATACTATGGGGTTTTTTTCAATATGCTTGTCTTTATGGCCCAATTTTGGGTCGCACTGTCTCCAATAGGAAATGGCGGAAAGTGTGATGCTCAGGCATTCTTCGAGAGTTATCTGGCTGCCCCGCTATGGATATTCATGTATGTTGGATACATGGTTTACAAAAGAGATTTTACCTTTTTAAACCCACTGGACAAGATCGACTTGGACTTTCATAGAAGAGTTTACGACCCTGAAATAATGAGGCAGGAGGACGAAGAAAATAAAGAAAGGTTAAAGAACTCTTCAATATTCGTCAGAGTCTACAAATTTTGGTGTTAG","protein_sequence":"MSDPIVTSSKMEKSAEFEVTDSALYNNFNTSTTASLTPEIKEHSEESRNGLVHRFVDSFRRAESQRLEEDNDLEDGTKSMKSNNHLKKSMKSRHVVMMSLGTGIGTGLLVANAKGLSLAGPGSLVIGYVMVSFVTYFMVQAAGEMGVTYPTLPGNFNAYNSIFISKSFGFATTWLFCIQWLTVLPLELITSSMTVKYWNDTINADVFIVIFYVFLLFIHFFGVKAYGETEFIFNSCKILMVAGFIILSVVINCGGAGVDGYIGGKYWRDPGSFAEGSGATRFKGICYILVSAYFSFGGIELFVLSINEQSNPRKSTPVAAKRSVYRILIIYLLTMILIGFNVPHNNDQLMGSGGSATHASPYVLAASIHKVRVIPHIINAVILISVISVANSALYAAPRLMCSLAQQGYAPKFLNYIDREGRPLRALVVCSLVGVVGFVACSPQEEQAFTWLAAIAGLSELFTWSGIMLSHIRFRKAMKVQGRSLDEVGYKANTGIWGSYYGVFFNMLVFMAQFWVALSPIGNGGKCDAQAFFESYLAAPLWIFMYVGYMVYKRDFTFLNPLDKIDLDFHRRVYDPEIMRQEDEENKERLKNSSIFVRVYKFWC"},{"created_at":"2011-05-26T16:30:36.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Protein MET17","uniprot_id":"P06106","uniprot_name":"MET17_YEAST","enzyme":true,"transporter":false,"gene_name":"MET17","num_residues":444,"molecular_weight":"48671.39844","theoretical_pi":"6.41","general_function":"Involved in pyridoxal phosphate binding","specific_function":"Transforms O-acetylhomoserine into homocysteine and O- acetylserine into cysteine","reactions":[{"id":1797,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1798,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2422,"direction":"\u003e","locations":"Cytoplasm","altext":"O-acetyl-L-homoserine + methanethiol = L-methionine + acetate.","export":false,"pw_reaction_id":null,"source":null},{"id":2420,"direction":"\u003e","locations":"Cytoplasm","altext":"O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate.","export":false,"pw_reaction_id":null,"source":null},{"id":3775,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006297","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY723848","genbank_protein_id":"51830472","gene_card_id":"MET17","chromosome_location":"chromosome 12","locus":"YLR303W","synonyms":["O-acetylhomoserine sulfhydrylase","OAH sulfhydrylase","Homocysteine synthase","O-acetylserine sulfhydrylase","OAS sulfhydrylase"],"enzyme_classes":["2.5.1.49","2.5.1.47"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGCCATCTCATTTCGATACTGTTCAACTACACGCCGGCCAAGAGAACCCTGGTGACAATGCTCACAGATCCAGAGCTGTACCAATTTACGCCACCACTTCTTATGTTTTCGAAAACTCTAAGCATGGTTCGCAATTGTTTGGTCTAGAAGTTCCAGGTTACGTCTATTCCCGTTTCCAAAACCCAACCAGTAATGTTTTGGAAGAAAGAATTGCTGCTTTAGAAGGTGGTGCTGCTGCTTTGGCTGTTTCCTCCGGTCAAGCCGCTCAAACCCTTGCCATCCAAGGTTTGGCACACACTGGTGACAACATCGTTTCCACTTCTTACTTATACGGTGGTACTTATAACCAGTTCAAAATCTCGTTCAAAAGATTTGGTATCGAGGCTAGATTTGTTGAAGGTGACAATCCAGAAGAATTCGAAAAGGTCTTTGATGAAAGAACCAAGGCTGTTTATTTGGAAACCATTGGTAATCCAAAGTACAATGTTCCGGATTTTGAAAAAATTGTTGCAATTGCTCACAAACACGGTATTCCAGTTGTCGTTGACAACACATTTGGTGCCGGTGGTTACTTCTGTCAGCCAATTAAATACGGTGCTGATATTGTAACACATTCTGCTACCAAATGGATTGGTGGTCATGGTACTACTATCGGTGGTATTATTGTTGACTCTGGTAAGTTCCCATGGAAGGACTACCCAGAAAAGTTCCCTCAATTCTCTCAACCTGCCGAAGGATATCACGGTACTATCTACAATGAAGCCTACGGTAACTTGGCATACATCGTTCATGTTAGAACTGAACTATTAAGAGATTTGGGTCCATTGATGAACCCATTTGCCTCTTTCTTGCTACTACAAGGTGTTGAAACATTATCTTTGAGAGCTGAAAGACACGGTGAAAATGCATTGAAGTTAGCCAAATGGTTAGAACAATCCCCATACGTATCTTGGGTTTCATACCCTGGTTTAGCATCTCATTCTCATCATGAAAATGCTAAGAAGTATCTATCTAACGGTTTCGGTGGTGTCTTATCTTTCGGTGTAAAAGACTTACCAAATGCCGACAAGGAAACTGACCCATTCAAACTTTCTGGTGCTCAAGTTGTTGACAATTTAAAGCTTGCCTCTAACTTGGCCAATGTTGGTGATGCCAAGACCTTAGTCATTGCTCCATACTTCACTACCCACAAACAATTAAATGACAAAGAAAAGTTGGCATCTGGTGTTACCAAGGACTTAATTCGTGTCTCTGTTGGTATCGAATTTATTGATGACATTATTGCAGACTTCCAGCAATCTTTTGAAACGGTTTTCGCTGGCCAAAAACCATGA","protein_sequence":"MPSHFDTVQLHAGQENPGDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTFGAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDYPEKFPQFSQPAEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSNGFGGVLSFGVKDLPNADKETDPFKLSGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETVFAGQKP"},{"created_at":"2011-05-26T17:19:36.000Z","updated_at":"2011-07-22T17:54:19.000Z","name":"Biotin synthase, mitochondrial","uniprot_id":"P32451","uniprot_name":"BIOB_YEAST","enzyme":true,"transporter":false,"gene_name":"BIO2","num_residues":375,"molecular_weight":"41883.80078","theoretical_pi":"8.66","general_function":"Involved in catalytic activity","specific_function":"Dethiobiotin + sulfur + 2 S-adenosyl-L- methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine","reactions":[{"id":1347,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2472,"direction":"\u003e","locations":"Mitochondrion","altext":"Dethiobiotin + sulfur + 2 S-adenosyl-L-methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine.","export":false,"pw_reaction_id":null,"source":null},{"id":3756,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006280","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"Z73071","genbank_protein_id":"1323523","gene_card_id":"BIO2","chromosome_location":"chromosome 7","locus":"YGR286C","synonyms":[],"enzyme_classes":["2.8.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring sulfur-containing groups"},{"category":"Function","description":" sulfurtransferase activity"},{"category":"Function","description":" biotin synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" vitamin metabolic process"},{"category":"Process","description":" water-soluble vitamin metabolic process"},{"category":"Process","description":" biotin metabolic process"},{"category":"Process","description":" biotin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" small molecule metabolic process"}],"pfams":[{"name":"Radical_SAM","identifier":"PF04055"},{"name":"BATS","identifier":"PF06968"}],"pathways":[{"name":"Biotin metabolism","kegg_map_id":"00780"},{"name":"Biotin Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGATGTCTACTATCTACCGTCATTTATCTACCGCTAGACCGGCTTTAACTAAATACGCAACCAATGCCGCAGTTAAATCGACAACTGCATCCTCAGAAGCTAGTACTCTGGGTGCTCTACAATATGCATTGTCTTTAGATGAACCAAGTCATTCGTGGACAAAATCGCAATTAAAAGAAATTTATCATACCCCACTGCTCGAACTTACTCATGCAGCACAATTGCAGCACAGAAAGTGGCACGATCCAACCAAAGTGCAATTGTGCACATTGATGAACATCAAATCTGGTGGTTGTTCTGAGGACTGTAAGTATTGTGCGCAGTCTTCGAGAAACGATACCGGTCTAAAGGCTGAGAAAATGGTTAAAGTGGATGAAGTGATTAAAGAGGCAGAAGAGGCCAAAAGAAACGGATCTACTAGATTCTGCCTAGGTGCTGCATGGAGAGACATGAAAGGTCGTAAATCAGCCATGAAAAGAATTCAGGAAATGGTGACCAAAGTGAATGATATGGGGCTAGAAACGTGTGTTACTTTAGGTATGGTTGATCAAGATCAAGCAAAGCAATTGAAAGATGCAGGTTTGACTGCATACAACCATAACATCGACACTTCCAGAGAACACTATAGTAAGGTCATCACCACGAGAACCTACGACGACAGGTTACAGACCATCAAGAATGTCCAAGAATCTGGAATAAAAGCCTGTACCGGTGGTATTTTGGGTCTCGGTGAAAGCGAAGACGACCATATAGGATTCATCTACACATTATCCAATATGTCTCCTCATCCTGAGTCCCTACCAATTAATAGACTAGTTGCTATCAAAGGGACTCCAATGGCTGAGGAACTTGCCGATCCAAAGAGTAAAAAGTTGCAATTCGACGAAATTTTGAGAACCATTGCCACAGCGAGAATAGTTATGCCAAAGGCCATTATAAGACTTGCCGCTGGTCGTTATACAATGAAAGAAACAGAGCAATTTGTCTGTTTCATGGCAGGTTGTAACAGTATCTTCACCGGTAAGAAAATGCTGACGACAATGTGTAACGGTTGGGACGAAGACAAGGCAATGTTGGCTAAATGGGGATTGCAACCTATGGAGGCATTTAAGTACGACAGATCTTGA","protein_sequence":"MMSTIYRHLSTARPALTKYATNAAVKSTTASSEASTLGALQYALSLDEPSHSWTKSQLKEIYHTPLLELTHAAQLQHRKWHDPTKVQLCTLMNIKSGGCSEDCKYCAQSSRNDTGLKAEKMVKVDEVIKEAEEAKRNGSTRFCLGAAWRDMKGRKSAMKRIQEMVTKVNDMGLETCVTLGMVDQDQAKQLKDAGLTAYNHNIDTSREHYSKVITTRTYDDRLQTIKNVQESGIKACTGGILGLGESEDDHIGFIYTLSNMSPHPESLPINRLVAIKGTPMAEELADPKSKKLQFDEILRTIATARIVMPKAIIRLAAGRYTMKETEQFVCFMAGCNSIFTGKKMLTTMCNGWDEDKAMLAKWGLQPMEAFKYDRS"},{"created_at":"2011-05-26T17:45:31.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"General amino acid permease AGP1","uniprot_id":"P25376","uniprot_name":"AGP1_YEAST","enzyme":false,"transporter":true,"gene_name":"AGP1","num_residues":633,"molecular_weight":"69670.70313","theoretical_pi":"6.97","general_function":"Involved in transport","specific_function":"Broad substrate range permease which transports asparagine and glutamine with intermediate specificity. Also transports Ala, Cys, Gly, Ile, Leu, Met, Phe, Ser, Thr, Tyr and Val. Important for the utilization of amino acids as a nitrogen source","reactions":[],"signal_regions":"None","transmembrane_regions":"125-145;149-169;198-218;232-252;261-281;314-334;353-373;403-425;453-473;478-498;532-552;561-581","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"AGP1","chromosome_location":"chromosome 3","locus":"YCL025C","synonyms":["Asparagine/glutamine permease"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGTCGTCGTCGAAGTCTCTATACGAACTGAAAGACTTGAAAAATAGCTCCACAGAAATACATGCCACGGGGCAGGATAATGAAATTGAATATTTCGAAACAGGCTCCAATGACCGTCCATCCTCACAACCTCATTTAGGTTACGAACAGCATAACACTTCTGCCGTGCGTAGGTTTTTCGACTCCTTTAAAAGAGCGGATCAGGGTCCACAGGATGAAGTAGAAGCAACACAAATGAACGATCTTACGTCGGCTATCTCACCTTCTTCTAGACAGGCTCAAGAACTAGAAAAAAATGAAAGTTCGGACAACATAGGCGCTAATACAGGTCATAAGTCGGACTCGCTGAAGAAAACCATTCAGCCTAGACATGTTCTGATGATTGCGTTGGGTACGGGTATCGGTACTGGGTTATTGGTCGGTAACGGTACCGCGTTGGTTCATGCGGGTCCAGCTGGACTACTTATTGGTTACGCTATTATGGGTTCTATCTTGTACTGTATTATTCAAGCATGTGGTGAAATGGCGCTAGTGTATAGTAACTTGACTGGTGGCTACAATGCATACCCCAGTTTCCTTGTGGATGATGGTTTTGGGTTTGCAGTCGCTTGGGTTTATTGTTTGCAATGGCTGTGTGTGTGTCCTCTGGAATTGGTGACCGCATCCATGACTATCAAATATTGGACGACATCTGTGAACCCGGATGTGTTCGTCATTATTTTCTATGTTTTGGTGATTACTATTAATATTTTCGGTGCTCGTGGTTATGCAGAAGCTGAGTTCTTCTTCAACTGTTGCAAAATTTTGATGATGACTGGGTTCTTCATTCTTGGTATTATCATCGATGTTGGTGGCGCTGGTAATGATGGTTTTATTGGTGGTAAATACTGGCACGATCCGGGCGCTTTCAATGGTAAACATGCCATTGACAGATTTAAAGGTGTTGCTGCAACATTAGTGACTGCTGCTTTTGCCTTTGGTGGTTCAGAGTTTATTGCCATCACCACTGCAGAACAATCTAATCCAAGAAAGGCCATTCCAGGTGCGGCCAAACAAATGATCTACAGAATCTTATTCCTATTCTTGGCTACCATTATTCTACTGGGTTTCTTGGTGCCATACAATTCCGATCAATTATTGGGTTCTACCGGTGGTGGTACTAAAGCCTCGCCATATGTCATTGCTGTTGCATCCCACGGTGTCCGTGTCGTCCCACACTTCATTAACGCCGTTATTCTACTTTCCGTGCTGTCCATGGCTAACTCCTCCTTCTACTCCAGTGCTCGTTTATTTTTAACTCTATCCGAGCAAGGTTACGCTCCTAAGGTTTTCTCCTACATCGACAGAGCCGGTAGACCATTGATTGCCATGGGTGTTTCTGCATTGTTTGCCGTTATTGCCTTCTGTGCTGCATCTCCCAAGGAAGAACAAGTTTTCACTTGGTTATTGGCCATTTCTGGTTTGTCTCAGCTTTTCACATGGACTGCCATTTGTTTATCCCATCTTAGATTTAGAAGAGCCATGAAAGTCCAAGGGAGATCTCTTGGAGAATTGGGTTTCAAATCTCAAACTGGTGTTTGGGGATCTGCCTACGCTTGCATTATGATGATTTTAATTCTTATTGCCCAATTTTGGGTCGCTATCGCCCCCATTGGTGAAGGTAAGCTGGATGCACAAGCCTTTTTCGAAAACTACTTGGCTATGCCAATCTTGATTGCACTTTATGTCGGCTACAAGGTCTGGCACAAGGATTGGAAACTGTTCATCAGGGCAGACAAGATCGACCTAGATTCTCATAGACAAATCTTTGATGAAGAATTAATCAAGCAAGAAGACGAAGAATATAGGGAACGTTTGAGGAACGGACCTTATTGGAAAAGGGTCGTTGCCTTCTGGTGTTAA","protein_sequence":"MSSSKSLYELKDLKNSSTEIHATGQDNEIEYFETGSNDRPSSQPHLGYEQHNTSAVRRFFDSFKRADQGPQDEVEATQMNDLTSAISPSSRQAQELEKNESSDNIGANTGHKSDSLKKTIQPRHVLMIALGTGIGTGLLVGNGTALVHAGPAGLLIGYAIMGSILYCIIQACGEMALVYSNLTGGYNAYPSFLVDDGFGFAVAWVYCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVIIFYVLVITINIFGARGYAEAEFFFNCCKILMMTGFFILGIIIDVGGAGNDGFIGGKYWHDPGAFNGKHAIDRFKGVAATLVTAAFAFGGSEFIAITTAEQSNPRKAIPGAAKQMIYRILFLFLATIILLGFLVPYNSDQLLGSTGGGTKASPYVIAVASHGVRVVPHFINAVILLSVLSMANSSFYSSARLFLTLSEQGYAPKVFSYIDRAGRPLIAMGVSALFAVIAFCAASPKEEQVFTWLLAISGLSQLFTWTAICLSHLRFRRAMKVQGRSLGELGFKSQTGVWGSAYACIMMILILIAQFWVAIAPIGEGKLDAQAFFENYLAMPILIALYVGYKVWHKDWKLFIRADKIDLDSHRQIFDEELIKQEDEEYRERLRNGPYWKRVVAFWC"},{"created_at":"2011-05-26T17:54:29.000Z","updated_at":"2011-07-22T17:53:51.000Z","name":"5-methyltetrahydropteroyltriglutamate--homocysteine 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L-methionine.","export":false,"pw_reaction_id":null,"source":null},{"id":3784,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006306","source":"Smpdb"},{"id":3785,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006776","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"DQ393811","genbank_protein_id":"88910023","gene_card_id":"MET6","chromosome_location":"chromosome 5","locus":"YER091C","synonyms":["Cobalamin-independent methionine synthase","Delta-P8 protein","Methionine synthase, vitamin-B12 independent isozyme"],"enzyme_classes":["2.1.1.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion 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L-methionyl-tRNA(Met).","export":false,"pw_reaction_id":null,"source":null},{"id":14293,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006774","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"V01316","genbank_protein_id":"3924","gene_card_id":"MES1","chromosome_location":"chromosome 7","locus":"YGR264C","synonyms":["Methionine--tRNA ligase","MetRS"],"enzyme_classes":["6.1.1.10"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ligase activity, forming carbon-oxygen bonds"},{"category":"Function","description":" ligase activity, forming aminoacyl-tRNA and related 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process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" tRNA aminoacylation"},{"category":"Process","description":" tRNA aminoacylation for protein translation"},{"category":"Process","description":" macromolecule biosynthetic process"},{"category":"Process","description":" cellular macromolecule biosynthetic process"},{"category":"Process","description":" translation"}],"pfams":[{"name":"tRNA-synt_1g","identifier":"PF09334"},{"name":"MetRS-N","identifier":"PF09635"}],"pathways":[{"name":"Selenocompound 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synthase 1","uniprot_id":"P10659","uniprot_name":"METK1_YEAST","enzyme":true,"transporter":false,"gene_name":"SAM1","num_residues":382,"molecular_weight":"41818.0","theoretical_pi":"4.83","general_function":"Involved in methionine adenosyltransferase activity","specific_function":"Catalyzes the formation of S-adenosylmethionine from methionine and ATP","reactions":[{"id":1728,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2580,"direction":"\u003e","locations":"","altext":"ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.","export":false,"pw_reaction_id":null,"source":null},{"id":3761,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006285","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"J03477","genbank_protein_id":"172534","gene_card_id":"SAM1","chromosome_location":"chromosome 12","locus":"YLR180W","synonyms":["AdoMet synthase 1","Methionine adenosyltransferase 1","MAT 1"],"enzyme_classes":["2.5.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" methionine adenosyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Process","description":" one-carbon metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"S-AdoMet_synt_C","identifier":"PF02773"},{"name":"S-AdoMet_synt_M","identifier":"PF02772"},{"name":"S-AdoMet_synt_N","identifier":"PF00438"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGGCCGGTACATTTTTATTCACTTCTGAATCCGTTGGTGAAGGTCACCCAGATAAGATCTGTGACCAAGTTTCCGACGCCATCTTGGACGCTTGTTTAGCCGAGGACCCTCACTCCAAAGTTGCGTGTGAAACCGCGGCAAAGACTGGTATGATTATGGTCTTTGGTGAAATTACTACCAAGGCACAGTTGGATTACCAAAAAATCGTCAGAGACACCATCAAGAAGATTGGTTACGATGATTCCGCCAAGGGTTTCGACTATAAGACCTGTAACGTCCTTGTCGCCATTGAGCAACAATCTCCAGATATCGCCCAAGGTGTCCACGAGGAGAAGGATTTGGAAGACATCGGTGCCGGTGACCAAGGTATCATGTTTGGTTACGCCACAGATGAAACTCCAGAGGGTTTGCCTTTGACTATTCTTTTGGCTCATAAACTAAACATGGCCATGGCTGACGCGAGAAGAGATGGCTCTTTAGCGTGGTTGAGACCAGACACCAAGACTCAAGTCACCGTCGAATACAAGGATGACCACGGTAGATGGGTTCCACAAAGAATCGACACCGTCGTCGTCTCCGCTCAACATGCTGACGAAATCACGACCGAGGACTTAAGAGCGCAACTAAAGTCCGAGATCATTGAAAAAGTCATCCCAAGAGACATGTTGGACGAAAACACCAAATACTTTATCCAACCTTCCGGTAGATTCGTCATCGGTGGTCCTCAAGGTGACACTGGTTTGACCGGTAGAAAGATCATCGTCGACGCTTACGGTGGTGCCTCATCCGTCGGTGGTGGTGCCTTCTCCGGTAAGGACTACTCTAAGGTTGATCGTTCTGCCGCTTATGCCGCTAGATGGGTTGCCAAGTCCCTAGTTGCCGCTGGTTTATGTAAGAGAGTTCAAGTTCAATTTTCTTATGCCATCGGTATTGCGGAACCATTGTCCTTGCACGTTGACACCTATGGTACTGCGACCAAGTCTGACGAAGAAATTATCGACATTATCAGCAAGAACTTTGACTTGAGACCTGGTGTATTGGTCAAGGAGTTGGACTTAGCTAGACCATTCTACTTGCCAACCGCTTCTTATGGCCATTTCACAAACCAAGAATACCCATGGGAAAAGCCTAAGACTTTGAAGTTCTAA","protein_sequence":"MAGTFLFTSESVGEGHPDKICDQVSDAILDACLAEDPHSKVACETAAKTGMIMVFGEITTKAQLDYQKIVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGVHEEKDLEDIGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLAWLRPDTKTQVTVEYKDDHGRWVPQRIDTVVVSAQHADEITTEDLRAQLKSEIIEKVIPRDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDEEIIDIISKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYPWEKPKTLKF"},{"created_at":"2011-05-27T02:12:57.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Lipoyl synthase, mitochondrial","uniprot_id":"P32875","uniprot_name":"LIPA_YEAST","enzyme":true,"transporter":false,"gene_name":"LIP5","num_residues":414,"molecular_weight":"46246.80078","theoretical_pi":"10.05","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (Probable)","reactions":[{"id":2662,"direction":"\u003e","locations":"Mitochondrion","altext":"Protein N(6)-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14866,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007053","source":"Smpdb"},{"id":14867,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007054","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY558046","genbank_protein_id":"45269982","gene_card_id":"LIP5","chromosome_location":"chromosome 15","locus":"YOR196C","synonyms":["Lipoate synthase","LS","Lip-syn","Lipoic acid synthase"],"enzyme_classes":["2.8.1.8"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" 4 iron, 4 sulfur cluster binding"},{"category":"Function","description":" transferase activity, transferring sulfur-containing groups"},{"category":"Function","description":" sulfurtransferase activity"},{"category":"Function","description":" lipoate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" lipoic acid metabolic process"},{"category":"Process","description":" lipoic acid biosynthetic process"},{"category":"Process","description":" lipoate biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"}],"pfams":[{"name":"Radical_SAM","identifier":"PF04055"}],"pathways":[{"name":"Lipoic acid metabolism","kegg_map_id":"00785"}],"gene_sequence":"ATGTATAGACGATCTGTTGGAGTACTATTTGTTGGGAGAAATACAAGATGGATTTCGTCCACTATTAGGTGTGGAACGAGCGCAACTCGGCCAATAAGATCCAATGCATTGAATACTGATTCAGATAACGCTAGCGTTAGGGTACCAGTTGGAAATTCAACTGAGGTTGAAAATGCAACCAGTCAGTTAACAGGGACTTCGGGAAAAAGACGCAAGGGGAACAGAAAAAGAATTACAGAGTTCAAAGATGCTCTTAATTTGGGTCCATCTTTTGCAGATTTTGTTTCAGGTAAAGCTTCGAAAATGATCTTGGACCCTCTGGAGAAGGCAAGGCAAAATACAGAGGAAGCTAAAAAACTACCTCGTTGGCTTAAGGTTCCTATTCCTAAGGGTACCAATTACCATAAATTGAAAGGCGACGTAAAAGAATTAGGCCTGAGTACTGTTTGTGAGGAGGCAAGATGTCCCAATATTGGTGAATGTTGGGGAGGCAAAGATAAATCTAAGGCAACGGCAACAATTATGCTGCTTGGTGATACTTGCACTCGTGGATGTAGGTTTTGTTCTGTGAAGACCAATAGAACGCCTAGTAAGCCGGACCCAATGGAGCCCGAAAATACTGCCGAAGCTATCAAAAGATGGGGGTTGGGTTATGTTGTTTTAACTACCGTTGATAGGGACGATTTAGTCGATGGTGGTGCTAATCACCTGGCCGAGACGGTTCGCAAAATCAAACAGAAGGCACCAAATACTCTTGTAGAGACTCTTTCTGGTGATTTCAGAGGTGATTTGAAGATGGTGGACATTATGGCACAATGTGGGCTTGATGTTTACGCACATAATTTGGAAACAGTTGAATCACTAACACCACATGTCAGAGACAGAAGAGCTACTTATAGACAGTCTTTGAGTGTTTTAGAAAGGGCAAAAGCTACGGTTCCGTCACTGATTACTAAAACATCAATAATGCTGGGTCTAGGAGAAACTGATGAGCAAATTACTCAAACTTTGAAGGATTTGCGCAATATTCAATGTGATGTTGTTACATTTGGTCAATATATGAGGCCAACCAAGAGACATATGAAAGTCGTAGAATATGTGAAACCCGAAAAGTTTGACTACTGGAAAGAGAGAGCTTTAGAGATGGGATTCTTGTATTGTGCATCTGGACCCCTAGTAAGATCGTCATATAAGGCTGGTGAAGCATTTATTGAGAACGTTTTGAAGAAAAGAAACATGAAATAA","protein_sequence":"MYRRSVGVLFVGRNTRWISSTIRCGTSATRPIRSNALNTDSDNASVRVPVGNSTEVENATSQLTGTSGKRRKGNRKRITEFKDALNLGPSFADFVSGKASKMILDPLEKARQNTEEAKKLPRWLKVPIPKGTNYHKLKGDVKELGLSTVCEEARCPNIGECWGGKDKSKATATIMLLGDTCTRGCRFCSVKTNRTPSKPDPMEPENTAEAIKRWGLGYVVLTTVDRDDLVDGGANHLAETVRKIKQKAPNTLVETLSGDFRGDLKMVDIMAQCGLDVYAHNLETVESLTPHVRDRRATYRQSLSVLERAKATVPSLITKTSIMLGLGETDEQITQTLKDLRNIQCDVVTFGQYMRPTKRHMKVVEYVKPEKFDYWKERALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRNMK"},{"created_at":"2011-05-27T02:15:50.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Aromatic amino acid aminotransferase 2","uniprot_id":"P38840","uniprot_name":"ARO9_YEAST","enzyme":true,"transporter":false,"gene_name":"ARO9","num_residues":513,"molecular_weight":"58527.0","theoretical_pi":"5.16","general_function":"Involved in transferase activity, transferring nitrogenous groups","specific_function":"Has aromatic amino acid transaminase activity and kynurenine aminotransferase activity","reactions":[{"id":1839,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2024,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2027,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2667,"direction":"\u003e","locations":"Cytoplasm","altext":"An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":3787,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006309","source":"Smpdb"},{"id":3788,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006518","source":"Smpdb"},{"id":3789,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006523","source":"Smpdb"},{"id":3790,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006536","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U10398","genbank_protein_id":"500670","gene_card_id":"ARO9","chromosome_location":"chromosome 8","locus":"YHR137W","synonyms":["Aromatic amino acid aminotransferase II","Aromatic amino acid-requiring protein 9"],"enzyme_classes":["2.6.1.57"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Aminotran_1_2","identifier":"PF00155"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACTGCTGGTTCTGCCCCCCCTGTTGATTACACTTCCTTAAAGAAGAACTTCCAACCGTTTCTCTCCAGAAGAGTAGAAAATAGATCTCTGAAAAGCTTTTGGGATGCTTCTGATATCTCAGATGACGTCATTGAGCTAGCTGGTGGAATGCCAAACGAGAGATTTTTTCCTATCGAATCTATGGATTTGAAAATATCAAAAGTTCCTTTTAATGATAACCCAAAATGGCATAATTCGTTTACCACGGCGCATTTGGACTTGGGATCCCCCAGTGAGCTACCCATTGCACGTTCTTTCCAATATGCAGAAACCAAGGGTTTACCCCCTCTCTTACATTTTGTTAAAGATTTTGTGTCCAGAATTAATCGCCCAGCCTTTTCCGATGAGACGGAGTCTAACTGGGATGTCATCCTTTCTGGCGGGTCCAACGATTCAATGTTTAAGGTTTTTGAAACAATTTGCGACGAATCGACCACTGTGATGATTGAAGAGTTTACTTTCACCCCGGCTATGTCCAATGTGGAGGCTACAGGAGCAAAAGTCATCCCCATCAAGATGAACCTGACCTTCGACAGAGAGTCCCAGGGTATTGATGTCGAATATCTAACGCAGTTGCTCGATAATTGGTCAACTGGACCATACAAAGACTTAAACAAGCCAAGGGTCCTATATACCATTGCAACGGGCCAAAATCCTACCGGGATGTCTGTCCCCCAGTGGAAAAGAGAGAAAATTTACCAGTTGGCCCAAAGACACGATTTCCTCATTGTTGAAGATGATCCCTACGGTTATCTGTACTTTCCTTCCTATAATCCGCAAGAGCCATTAGAAAACCCTTACCATTCTAGCGACCTGACTACTGAACGGTATTTGAATGATTTTTTAATGAAATCATTCTTGACTTTGGATACAGATGCCCGTGTCATCCGTTTGGAGACTTTTTCTAAAATTTTTGCTCCTGGATTAAGGTTATCCTTCATCGTTGCTAATAAATTCCTTTTGCAAAAAATCTTGGATTTGGCCGACATTACTACAAGGGCCCCCAGTGGTACCTCACAAGCTATTGTTTATTCTACAATAAAGGCAATGGCTGAGTCCAACTTATCGTCCTCTCTTTCTATGAAAGAAGCAATGTTTGAGGGTTGGATAAGATGGATAATGCAGATTGCTTCTAAATACAATCATAGGAAAAATCTTACTTTGAAAGCCTTATACGAAACAGAATCTTACCAAGCTGGTCAGTTTACCGTTATGGAACCCTCCGCGGGTATGTTCATCATTATTAAAATCAATTGGGGGAATTTCGATAGACCTGACGATTTGCCGCAACAGATGGATATTTTAGATAAGTTCTTGCTGAAGAATGGTGTTAAAGTAGTGCTTGGTTATAAAATGGCTGTTTGCCCAAATTATTCAAAGCAGAATTCAGATTTTCTAAGACTCACCATCGCCTATGCAAGGGATGATGATCAGTTGATTGAAGCTTCCAAAAGAATCGGTAGTGGCATAAAAGAATTTTTTGACAACTATAAAAGTTGA","protein_sequence":"MTAGSAPPVDYTSLKKNFQPFLSRRVENRSLKSFWDASDISDDVIELAGGMPNERFFPIESMDLKISKVPFNDNPKWHNSFTTAHLDLGSPSELPIARSFQYAETKGLPPLLHFVKDFVSRINRPAFSDETESNWDVILSGGSNDSMFKVFETICDESTTVMIEEFTFTPAMSNVEATGAKVIPIKMNLTFDRESQGIDVEYLTQLLDNWSTGPYKDLNKPRVLYTIATGQNPTGMSVPQWKREKIYQLAQRHDFLIVEDDPYGYLYFPSYNPQEPLENPYHSSDLTTERYLNDFLMKSFLTLDTDARVIRLETFSKIFAPGLRLSFIVANKFLLQKILDLADITTRAPSGTSQAIVYSTIKAMAESNLSSSLSMKEAMFEGWIRWIMQIASKYNHRKNLTLKALYETESYQAGQFTVMEPSAGMFIIIKINWGNFDRPDDLPQQMDILDKFLLKNGVKVVLGYKMAVCPNYSKQNSDFLRLTIAYARDDDQLIEASKRIGSGIKEFFDNYKS"},{"created_at":"2011-05-27T03:41:09.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Homocysteine S-methyltransferase 1","uniprot_id":"Q12525","uniprot_name":"MHT1_YEAST","enzyme":true,"transporter":false,"gene_name":"MHT1","num_residues":324,"molecular_weight":"36714.5","theoretical_pi":"5.26","general_function":"Involved in homocysteine S-methyltransferase activity","specific_function":"Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S- methylmethionine (SMM) to methionine","reactions":[{"id":1637,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2739,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"S-methyl-L-methionine + L-homocysteine = 2 L-methionine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY558194","genbank_protein_id":"45270278","gene_card_id":"MHT1","chromosome_location":"chromosome 12","locus":"YLL062C","synonyms":["S-methylmethionine:homocysteine methyltransferase 1","SMM:Hcy S-methyltransferase 1"],"enzyme_classes":["2.1.1.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" S-methyltransferase activity"},{"category":"Function","description":" homocysteine S-methyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"S-methyl_trans","identifier":"PF02574"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"}],"gene_sequence":"ATGAAGCGCATTCCAATCAAAGAACTAATAGTTGAGCACCCCGGAAAAGTTCTTATCCTTGATGGTGGACAGGGTACAGAATTGGAAAACAGAGGCATTAACATAAATAGTCCGGTATGGTCTGCAGCTCCTTTTACGAGCGAATCCTTTTGGGAGCCATCTTCTCAAGAGCGAAAGGTGGTAGAAGAAATGTACAGAGACTTTATGATTGCTGGCGCAAACATATTAATGACAATTACTTACCAGGCAAACTTTCAAAGCATATCTGAGAATACCTCGATTAAAACTCTGGCTGCTTACAAGCGTTTTCTCGATAAAATCGTGTCATTTACTCGTGAATTTATTGGTGAGGAAAGGTACTTAATCGGGAGTATTGGCCCATGGGCAGCACATGTATCCTGTGAATATACTGGTGACTATGGTCCCCATCCTGAGAATATTGATTACTACGGCTTTTTCAAACCCCAGCTGGAGAACTTCAACCAAAATAGAGATATTGATCTTATTGGTTTTGAAACGATTCCAAATTTTCATGAGTTAAAGGCTATTTTATCCTGGGATGAAGATATTATTTCGAAGCCCTTTTATATTGGGTTGTCGGTGGATGACAATAGTTTGCTACGAGACGGTACCACTTTGGAAGAAATTTCTGTCCATATAAAAGGCCTCGGAAATAAAATTAACAAGAATCTCTTATTAATGGGAGTTAACTGTGTCAGTTTCAATCAATCGGCATTAATTCTTAAAATGTTGCACGAGCATCTACCTGGCATGCCTCTGCTAGTTTACCCAAACAGTGGAGAAATCTACAATCCCAAAGAGAAGACATGGCACCGGCCGACTAATAAGTTGGATGACTGGGAGACCACGGTTAAGAAATTCGTTGATAATGGTGCGCGCATTATTGGCGGTTGTTGTAGAACGTCTCCTAAAGATATCGCCGAAATTGCATCAGCTGTAGATAAATACTCCTAA","protein_sequence":"MKRIPIKELIVEHPGKVLILDGGQGTELENRGININSPVWSAAPFTSESFWEPSSQERKVVEEMYRDFMIAGANILMTITYQANFQSISENTSIKTLAAYKRFLDKIVSFTREFIGEERYLIGSIGPWAAHVSCEYTGDYGPHPENIDYYGFFKPQLENFNQNRDIDLIGFETIPNFHELKAILSWDEDIISKPFYIGLSVDDNSLLRDGTTLEEISVHIKGLGNKINKNLLLMGVNCVSFNQSALILKMLHEHLPGMPLLVYPNSGEIYNPKEKTWHRPTNKLDDWETTVKKFVDNGARIIGGCCRTSPKDIAEIASAVDKYS"},{"created_at":"2011-05-27T03:42:09.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Homocysteine S-methyltransferase 2","uniprot_id":"Q08985","uniprot_name":"SAM4_YEAST","enzyme":true,"transporter":false,"gene_name":"SAM4","num_residues":325,"molecular_weight":"36668.19922","theoretical_pi":"4.88","general_function":"Involved in homocysteine S-methyltransferase activity","specific_function":"Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S- methylmethionine (SMM) to methionine","reactions":[{"id":1637,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2739,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"S-methyl-L-methionine + L-homocysteine = 2 L-methionine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"Z73629","genbank_protein_id":"1370563","gene_card_id":"SAM4","chromosome_location":"chromosome 16","locus":"YPL273W","synonyms":["S-adenosylmethionine metabolism protein 4","S-methylmethionine:homocysteine methyltransferase 2","SMM:Hcy S-methyltransferase 2"],"enzyme_classes":["2.1.1.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" S-methyltransferase activity"},{"category":"Function","description":" homocysteine S-methyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"S-methyl_trans","identifier":"PF02574"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"}],"gene_sequence":"ATGGCACGTCTTCCTCTAAAGCAGTTCTTAGCGGATAACCCCAAAAAAGTTCTTGTTCTTGACGGTGGTCAAGGAACAGAACTGGAAAACAGAGGTATCAAAGTTGCAAATCCCGTGTGGTCTACTATTCCATTTATTAGCGAATCATTTTGGTCTGATGAGTCATCTGCTAACAGAAAAATTGTCAAAGAAATGTTCAACGATTTCTTGAATGCTGGCGCAGAAATATTGATGACTACAACATACCAAACGAGTTATAAATCAGTTTCTGAAAACACCCCAATCAGAACTTTATCCGAGTACAATAACCTTTTAAACAGGATTGTCGATTTTTCTCGTAATTGTATTGGCGAAGACAAATATTTGATTGGCTGTATTGGCCCATGGGGTGCTCATATTTGTCGTGAGTTTACAGGCGACTATGGTGCTGAGCCAGAAAATATTGATTTCTACCAATACTTCAAGCCTCAGTTGGAGAATTTCAATAAAAATGACAAATTGGATTTGATTGGGTTTGAAACCATTCCTAACATCCATGAACTGAAAGCTATCTTATCTTGGGATGAGAGTATCCTGTCTAGACCCTTCTATATCGGGTTGTCTGTGCATGAGCACGGTGTCTTGAGAGACGGCACTACCATGGAAGAAATCGCACAAGTTATTAAGGACTTGGGCGACAAAATAAATCCTAACTTCTCGTTCTTAGGAATCAACTGCGTCAGCTTCAACCAATCACCCGACATTCTTGAGTCTCTACATCAAGCACTACCAAATATGGCCTTGCTTGCTTATCCAAACAGTGGTGAAGTTTATGATACTGAAAAGAAGATATGGTTGCCAAATAGCGATAAGCTGAACAGTTGGGATACGGTTGTTAAACAGTACATTAGCAGCGGTGCCCGTATCATTGGTGGTTGTTGCAGAACAAGTCCAAAAGACATCCAAGAGATTTCTGCAGCCGTCAAGAAATACACGTAA","protein_sequence":"MARLPLKQFLADNPKKVLVLDGGQGTELENRGIKVANPVWSTIPFISESFWSDESSANRKIVKEMFNDFLNAGAEILMTTTYQTSYKSVSENTPIRTLSEYNNLLNRIVDFSRNCIGEDKYLIGCIGPWGAHICREFTGDYGAEPENIDFYQYFKPQLENFNKNDKLDLIGFETIPNIHELKAILSWDESILSRPFYIGLSVHEHGVLRDGTTMEEIAQVIKDLGDKINPNFSFLGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNSDKLNSWDTVVKQYISSGARIIGGCCRTSPKDIQEISAAVKKYT"},{"created_at":"2011-05-27T06:45:31.000Z","updated_at":"2011-05-27T15:01:26.000Z","name":"Peptide methionine sulfoxide reductase","uniprot_id":"P40029","uniprot_name":"MSRA_YEAST","enzyme":true,"transporter":false,"gene_name":"MXR1","num_residues":184,"molecular_weight":"21140.69922","theoretical_pi":"7.01","general_function":"Involved in oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor","specific_function":"Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Also able to reduce dimethyl sulfoxide (DMSO) as well, with DMS as the product","reactions":[{"id":2794,"direction":"\u003e","locations":null,"altext":"Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.","export":false,"pw_reaction_id":null,"source":null},{"id":2795,"direction":"\u003e","locations":null,"altext":"L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY692798","genbank_protein_id":"51013047","gene_card_id":"MXR1","chromosome_location":"chromosome 5","locus":"YER042W","synonyms":["Peptide-methionine (S)-S-oxide reductase","Peptide Met(O) reductase","Protein-methionine-S-oxide reductase"],"enzyme_classes":["1.8.4.11"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" protein metabolic process"}],"pfams":[{"name":"PMSR","identifier":"PF01625"}],"pathways":[],"gene_sequence":"ATGTCGTCGCTTATTTCAAAAACCATTAAGTATGATCCAGCCAAGGATAAATTAATCACATTAGCATGTGGATGTTTTTGGGGTACAGAACATATGTATAGGAAGTATTTGAATGACCGTATAGTGGATTGTAAAGTAGGTTACGCTAATGGAGAAGAGTCTAAAAAGGATAGCCCCTCTAGTGTCTCTTATAAGAGAGTTTGTGGTGGTGACACAGATTTTGCGGAGGTTTTACAAGTATCCTATAATCCCAAAGTGATAACTTTGAGAGAATTAACTGATTTCTTTTTTAGAATCCATGATCCTACTACATCTAATTCACAAGGACCTGATAAAGGTACACAGTATCGCAGTGGATTGTTCGCTCATTCAGATGCTGATTTAAAAGAATTAGCCAAAATAAAGGAAGAATGGCAACCAAAATGGGGTAATAAGATTGCCACAGTTATTGAACCAATCAAGAACTTTTACGATGCTGAAGAATACCACCAGTTATATTTAGATAAGAATCCACAGGGATATGCATGCCCTACTCATTATCTGAGAGAAATGTAG","protein_sequence":"MSSLISKTIKYDPAKDKLITLACGCFWGTEHMYRKYLNDRIVDCKVGYANGEESKKDSPSSVSYKRVCGGDTDFAEVLQVSYNPKVITLRELTDFFFRIHDPTTSNSQGPDKGTQYRSGLFAHSDADLKELAKIKEEWQPKWGNKIATVIEPIKNFYDAEEYHQLYLDKNPQGYACPTHYLREM"},{"created_at":"2011-05-27T06:46:06.000Z","updated_at":"2011-05-27T15:01:26.000Z","name":"Methionine aminopeptidase 1","uniprot_id":"Q01662","uniprot_name":"AMPM1_YEAST","enzyme":true,"transporter":false,"gene_name":"MAP1","num_residues":387,"molecular_weight":"43373.0","theoretical_pi":"7.96","general_function":"Involved in aminopeptidase activity","specific_function":"Removes the amino-terminal methionine from nascent proteins","reactions":[],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"M77092","genbank_protein_id":"975723","gene_card_id":"MAP1","chromosome_location":"chromosome 12","locus":"YLR244C","synonyms":["MAP 1","MetAP 1","Peptidase M 1"],"enzyme_classes":["3.4.11.18"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metallopeptidase activity"},{"category":"Function","description":" metalloexopeptidase activity"},{"category":"Function","description":" exopeptidase activity"},{"category":"Function","description":" aminopeptidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" peptidase activity"},{"category":"Function","description":" peptidase activity, acting on L-amino acid peptides"},{"category":"Process","description":" proteolysis"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" protein metabolic process"}],"pfams":[{"name":"Peptidase_M24","identifier":"PF00557"}],"pathways":[],"gene_sequence":"ATGAGCACTGCAACTACAACAGTTACTACCTCCGATCAGGCTTCTCATCCTACCAAGATATATTGCTCCGGTTTGCAATGTGGTAGAGAAACTTCGTCCCAAATGAAATGCCCTGTTTGTCTAAAACAAGGCATCGTTTCCATTTTCTGCGACACAAGCTGTTATGAAAACAACTACAAAGCTCACAAAGCTTTGCACAATGCTAAGGACGGCTTGGAAGGTGCTTATGATCCTTTCCCAAAATTCAAATATTCTGGTAAAGTGAAGGCTTCATATCCACTTACCCCAAGAAGGTATGTCCCTGAAGATATTCCTAAACCGGACTGGGCCGCTAATGGGCTACCAGTCAGTGAACAAAGAAATGATAGACTTAACAACATCCCTATATACAAGAAAGATCAAATTAAGAAGATTAGAAAGGCATGTATGTTGGGTAGAGAAGTTCTTGATATTGCCGCTGCCCATGTCAGACCAGGCATCACTACAGATGAATTAGATGAAATCGTCCACAATGAAACAATTAAGAGAGGTGCCTACCCTTCCCCTCTTAATTATTACAACTTTCCTAAATCGCTTTGTACCTCTGTCAATGAAGTTATTTGTCACGGTGTGCCCGATAAAACTGTCTTGAAGGAAGGTGATATTGTCAATTTAGATGTTTCCTTATACTACCAAGGTTATCATGCAGACTTGAATGAGACATATTATGTCGGCGAAAACATTTCTAAGGAAGCTCTTAATACTACTGAGACCTCAAGAGAATGTTTGAAACTAGCCATTAAAATGTGTAAGCCAGGTACCACCTTCCAAGAGTTAGGTGATCATATTGAAAAACACGCTACCGAAAATAAGTGCAGTGTAGTAAGAACTTATTGTGGACATGGTGTTGGTGAATTTTTCCATTGTTCCCCAAATATTCCCCACTACGCCAAGAATAGAACACCTGGTGTTATGAAACCAGGTATGGTTTTCACCATCGAACCTATGATTAATGAAGGTACTTGGAAGGATATGACCTGGCCTGATGACTGGACTTCTACCACCCAAGACGGTAAACTGAGTGCTCAATTTGAACATACACTGTTGGTTACCGAACATGGTGTTGAAATCCTAACAGCCAGGAATAAGAAATCACCAGGTGGCCCAAGACAGAGAATTAAATAG","protein_sequence":"MSTATTTVTTSDQASHPTKIYCSGLQCGRETSSQMKCPVCLKQGIVSIFCDTSCYENNYKAHKALHNAKDGLEGAYDPFPKFKYSGKVKASYPLTPRRYVPEDIPKPDWAANGLPVSEQRNDRLNNIPIYKKDQIKKIRKACMLGREVLDIAAAHVRPGITTDELDEIVHNETIKRGAYPSPLNYYNFPKSLCTSVNEVICHGVPDKTVLKEGDIVNLDVSLYYQGYHADLNETYYVGENISKEALNTTETSRECLKLAIKMCKPGTTFQELGDHIEKHATENKCSVVRTYCGHGVGEFFHCSPNIPHYAKNRTPGVMKPGMVFTIEPMINEGTWKDMTWPDDWTSTTQDGKLSAQFEHTLLVTEHGVEILTARNKKSPGGPRQRIK"},{"created_at":"2011-05-27T06:47:01.000Z","updated_at":"2011-05-29T05:06:45.000Z","name":"Methionine aminopeptidase 2","uniprot_id":"P38174","uniprot_name":"AMPM2_YEAST","enzyme":true,"transporter":false,"gene_name":"MAP2","num_residues":421,"molecular_weight":"47502.19922","theoretical_pi":"6.29","general_function":"Involved in aminopeptidase activity","specific_function":"Removes the amino-terminal methionine from nascent proteins","reactions":[],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U17437","genbank_protein_id":"1045302","gene_card_id":"MAP2","chromosome_location":"chromosome 2","locus":"YBL091C","synonyms":["MetAP 2","Peptidase M 2"],"enzyme_classes":["3.4.11.18"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metallopeptidase activity"},{"category":"Function","description":" metalloexopeptidase activity"},{"category":"Function","description":" exopeptidase activity"},{"category":"Function","description":" aminopeptidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" peptidase activity"},{"category":"Function","description":" peptidase activity, acting on L-amino acid peptides"},{"category":"Process","description":" proteolysis"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" protein metabolic process"}],"pfams":[{"name":"Peptidase_M24","identifier":"PF00557"}],"pathways":[],"gene_sequence":"ATGACAGACGCTGAAATAGAAAATTCCCCTGCTTCTGATTTAAAAGAATTGAATTTGGAGAATGAAGGCGTTGAACAGCAAGACCAGGCAAAAGCTGACGAGTCAGACCCAGTAGAAAGCAAAAAGAAGAAGAACAAGAAAAAGAAGAAGAAGAAAAGCAATGTGAAGAAGATTGAATTACTGTTTCCAGATGGAAAGTACCCAGAAGGTGCGTGGATGGACTATCATCAAGATTTCAATCTGCAAAGAACCACGGATGAAGAATCACGTTATTTGAAAAGGGATCTGGAAAGGGCCGAACATTGGAATGATGTCAGAAAGGGTGCTGAGATACATCGTCGTGTGAGAAGGGCCATCAAGGACAGAATCGTTCCTGGGATGAAGTTAATGGATATCGCTGACATGATCGAAAATACTACAAGAAAGTATACAGGTGCCGAAAATTTATTAGCGATGGAGGATCCCAAATCTCAAGGTATTGGGTTTCCAACGGGTCTCTCTCTCAACCATTGTGCTGCACATTTCACACCCAATGCAGGCGACAAAACCGTTCTGAAATACGAAGACGTGATGAAGGTAGATTATGGTGTGCAGGTAAACGGTAACATCATTGATTCTGCCTTTACTGTTTCCTTTGATCCACAATACGATAACCTGCTAGCCGCTGTAAAGGACGCTACTTACACGGGTATTAAAGAAGCGGGTATCGATGTGAGATTAACCGACATCGGTGAAGCCATCCAAGAAGTTATGGAATCCTACGAAGTGGAAATCAATGGTGAGACTTACCAGGTTAAACCTTGTCGTAATCTATGTGGCCACAGTATCGCACCATATCGTATCCACGGCGGTAAATCCGTTCCCATCGTCAAAAATGGGGACACTACAAAAATGGAGGAAGGTGAGCACTTTGCCATTGAAACTTTTGGTTCTACTGGTAGAGGTTATGTTACTGCCGGTGGGGAAGTTTCTCATTATGCCAGATCTGCTGAAGACCATCAGGTAATGCCCACGTTAGACAGCGCCAAGAACTTGTTAAAAACGATAGACCGCAACTTTGGGACTTTACCGTTCTGTCGCCGATACCTAGACAGACTTGGCCAAGAGAAATACTTATTTGCGTTGAATAACTTGGTTAGACACGGTTTAGTACAGGATTATCCACCATTGAACGATATCCCCGGATCCTACACTGCACAATTCGAACACACCATCTTGTTGCATGCTCACAAAAAGGAAGTCGTTTCGAAAGGTGATGACTACTGA","protein_sequence":"MTDAEIENSPASDLKELNLENEGVEQQDQAKADESDPVESKKKKNKKKKKKKSNVKKIELLFPDGKYPEGAWMDYHQDFNLQRTTVEESRYLKRDLERAEHWNDVRKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYTGAENLLAMEDPKSQGIGFPTGLSLNHCAAHFTPNAGDKTVLKYEDVMKVDYGVQVNGNIIDSAFTVSFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESYEVEINGETYQVKPCRNLCGHSIAPYRIHGGKSVPIVKNGDTTKMEEGEHFAIETFGSTGRGYVTAGGEVSHYARSAEDHQVMPTLDSAKNLLKTIDRNFGTLPFCRRYLDRLGQEKYLFALNNLVRHGLVQDYPPLNDIPGSYTAQFEHTILLHAHKKEVVSKGDDY"},{"created_at":"2011-05-27T06:47:46.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"Low-affinity methionine permease","uniprot_id":"P38734","uniprot_name":"MUP3_YEAST","enzyme":false,"transporter":true,"gene_name":"MUP3","num_residues":546,"molecular_weight":"60619.10156","theoretical_pi":"8.95","general_function":"Involved in transport","specific_function":"Very low affinity permease for methionine","reactions":[],"signal_regions":"None","transmembrane_regions":"71-91;99-119;149-169;189-209;214-234;255-275;298-318;320-340;347-367;394-414;424-444;460-480;495-515","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":"U11583","genbank_protein_id":"2289865","gene_card_id":"MUP3","chromosome_location":"chromosome 8","locus":"YHL036W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGGAACCGCTGCTTTTTAATAGTGGGAAAGCAAATCCCTCTCAAGATGTTTTCATAGATGTGGAAGTTGGTGATATTACCACAAAATATGGTTCCACAAATACTGGATCATTCAGTTCGATGGATACTGTGGAAGCGCAGGCGATAAAGGCAGAGACGGCAAGATTCATGGAAGTTCCACAGGGAAGACATTTAGGTGTGTTCTCCACGGTTGTGTTATTTGTTTCGAGGATAATGGGGTCAGGTATATTTGCAGTACCCAGTGTGATTTTACTGAATACAGGTGGTAATAAGCTGATATATTTTGCGATCTGGGTTTTTAGCGCTGCGATCGCTTTTGCAGGATTGTATCTTTTTCTAGAATTTGGTTCCTGGATACCGAAATCAGGTGGACGTAAAAACTTCCTCGAACGGAGTTTTGAAAGACCCAGACTATTAATTAGTGTGGTGTTTTCGTGTTACAGTGTTTTAACTGGCTATGCATTGACGGGATCTATCGTCTTCGGTAAATACGTGTTGAGCGCATTTGGAGTCACGGATGATTCGTGGTCCAAGTACGTCAGCATATCATTTATAATATTTGCCGTTCTCATTCACGGTGTCTCTGTAAGGCACGGAGTGTTTATACAGAACGCACTTGGTGGTTTGAAGTTGATCATGATTGTCTTGATGTGCTTTGCCGGGCTATACACGCTTTTCTTTTATAAAAGCACCGGTCAAGTTGCCTGGGACCTCCCAGTAACCCAAGTTGAGAAAGATTCTCTCCTGTCGGTGTCCTCTATTGCTACTGCCTTTATCAGCTCATTCTTTTGTTTTTCTGGATGGGATACAGTTCACACAGTTACATCAGAAATTAAGAATCCCGTTAAGACGTTGAAGGTGTCAGGTCCCTTATCGTTGATAATTTGTTTTGTCTGCTACACAATGATGAATGTGGCATACTTGAAAGTTTTGACATATGAGGAAATTGTTAGTGCAGGCCCCCTGGTTGGTTCCGTGTTGTTTACCAAACTTTTCGGACCCAGAGTTGGTGGCAAATTCATTGCTTTTTCTATCGCCATTTCTGCAGCATCTAATATTCTGGTTGTCATTTACAGTATATCAAGAGTTAACCAGGAAATATTCAAAGAAGGTTATTTACCATTCAGTATTCATATGTCCAAAAATTGGCCATTTGATGCACCTCTACCATCTATTTCTTTATGTGGCTTTATAACCATTGCTTGGATATTGATTTTACCCAAAGAGGGCGAATCCTTCAATTATCTGGTATCGATGGATGGTTATGGTAATCAGTTTTTCTTATTATTGGTCGCTATTGGGCTCTTTATTTGGAGGTTCAAACACAAGAACGAAGTCCCAGAGATTCGTGCATCTACTTTTGGAGTATTAGCCATTATTACATTATCATTATACATGTTGATGGCACCATTCTTTGCCGACCCTAGCCTAAACAGAGTTGGGTTCCTGCCGCCCTACCAAATCATGTCATTACTGGTAATAGTTGCATGCTTCTTTTTCTGGTTAGTTAAATTCGTTTTACTACCTAAATTCTTCCATTATAAACTTTTACCCAAAATCACTTATTTGCATGATGGGCTCATTGTCACAGAATGGGTGAAAAAGCCATGTCTGTGTTAG","protein_sequence":"MEPLLFNSGKANPSQDVFIDVEVGDITTKYGSTNTGSFSSMDTVEAQAIKAETARFMEVPQGRHLGVFSTVVLFVSRIMGSGIFAVPSVILLNTGGNKLIYFAIWVFSAAIAFAGLYLFLEFGSWIPKSGGRKNFLERSFERPRLLISVVFSCYSVLTGYALTGSIVFGKYVLSAFGVTDDSWSKYVSISFIIFAVLIHGVSVRHGVFIQNALGGLKLIMIVLMCFAGLYTLFFYKSTGQVAWDLPVTQVEKDSLLSVSSIATAFISSFFCFSGWDTVHTVTSEIKNPVKTLKVSGPLSLIICFVCYTMMNVAYLKVLTYEEIVSAGPLVGSVLFTKLFGPRVGGKFIAFSIAISAASNILVVIYSISRVNQEIFKEGYLPFSIHMSKNWPFDAPLPSISLCGFITIAWILILPKEGESFNYLVSMDGYGNQFFLLLVAIGLFIWRFKHKNEVPEIRASTFGVLAIITLSLYMLMAPFFADPSLNRVGFLPPYQIMSLLVIVACFFFWLVKFVLLPKFFHYKLLPKITYLHDGLIVTEWVKKPCLC"},{"created_at":"2011-05-27T06:49:04.000Z","updated_at":"2011-05-27T15:01:27.000Z","name":"High-affinity methionine permease","uniprot_id":"P50276","uniprot_name":"MUP1_YEAST","enzyme":false,"transporter":true,"gene_name":"MUP1","num_residues":574,"molecular_weight":"63220.80078","theoretical_pi":"7.78","general_function":"Involved in transport","specific_function":"High affinity permease for methionine","reactions":[],"signal_regions":"None","transmembrane_regions":"62-82;93-113;141-161;183-203;208-228;294-314;341-361;419-439;456-476;491-511","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":"DQ115391","genbank_protein_id":"71064041","gene_card_id":"MUP1","chromosome_location":"chromosome 7","locus":"YGR055W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGTCGGAAGGAAGAACGTTTCTGTCACAGTTGAATGTCTTCAACAAGGAGAACTATCAATTTTCTTCTTCTACTACAAAAAAGGAAGTAAGTAACTCAACAGTGGATGCTGACAACGGTGCCTCCGATTTTGAGGCAGGCCAGCAATTTGCTACAGAATTGGACCAAGGTGAAAAGCAGTTAGGTATTTTGTCGTGTATTGGGCTTATCTGTAATAGAATGCTTGGTACCGGTGTTTTCGCCGTTTCCTCGACCATTTACACACTATGTGGGTCTGTGGGGCTTGCATTAATTATGTGGGCAGTTGGTGCCATTATTGCCATTTCTGGGTTATATGTATACATGGAATTCGGTACGGCTATACCGAAAAATGGTGGTGAAAAAAACTACCTGGAGGCCATTTTCAGGAAACCAAAATTCTTCATTACCTGTATGTATGCTGCGTATATTTTCTTCCTAGGTTGGGCTGCTGGTAATTCTATCAATACAGCTATTATGTTTTTAACTGCTGCTGATACTGAAGTGACCAAATGGAATCAAAGAGGTATTGGTGTGGCCGTCGTTTTTTTTGCATTCCTAATTAATTCTCTGAATGTCAAGATTGGTCTATATTTGCAAAACATTTTAGGTATTTTCAAGATTGGTATTGTCCTCTTCATTTCTATTACCGGTTGGGTTGCCCTTGGCGGTGGTCTCAAAGATGGTTATCAATCTCACAACTTTCGTAATGCTTTTGAAGGTACTGAAACCGCCACTGCTTATGGTATTGTTAACGCCTTATATAGTGTTATTTGGTCGTTTGTCGGTTACTCCAATGTTAACTATGCACTTGGTGAAGTTAAGAACCCTGTGAGAACTTTGAAGATTGCTGGTCCTACATCGATGGTCTTCTTGGCTATAATCTACATTTTTGTGAACATTGCTTACTTCGCTGTGGTTCCAAAAGATAAGTTAATTTCTTCAAAATTGATTTTAGCTGCTGACTTCTTCGATATTGTGTTTGGCGGCCAAGCCAAGAGAGCAGCAGCCGCACTGGTCGGGTTGAGTGCCTTAGGAAATGTTCTTTCTGTCATTTTTTCTCAGGGTAGAATTATTCAACAACTAGGACGTGAAGGTGTGTTGCCCTTTTCTAATTTCTTTGCCTCTTCTAAGCCATTCAACTCCCCAATGGTTGGTTTGTTTCAACATTTTATTGTTTGTACAGTAACCATCTTAGCCCCACCTCCAGGTGATGCATATTTGCTAGTCCAAAATTTAATTTCCTACCCAATGAATATTATTAATTTTGCTATTAGCGCGGGTTTGCTTTGGATATACTGGCAACGTAGACAAGGTAAAATTGAATGGAACCCACCAATTAAGGCCGGTGTTTTTGTTACGGGATTTTTCACATTATCCAATTTATACCTGATTATTGCTCCTTACGTTCCACCTTCAAATGGCGAGTCGGTGTATTCAAGCATGCCATACTGGATCCACTGTGTAATTGCTTGGGGTATTTTCTTCTTTGGTGGTGTTTACTACGTTGTTTGGGCCCAATTATTGCCAAGATGGGGCCACTACAAATTGGTTTCCAAGGATGTGCTTGGTGAAGATGGGTTCTGGAGAGTCAAAATTGCCAAAGTTTATGATGACACTATTGGCGATGTCGATACACAAGAAGACGGCGTTATTGAAACGAATATAATCGAACATTACAAAAGTGAACAAGAAAAATCGCTGTAA","protein_sequence":"MSEGRTFLSQLNVFNKENYQFSSSTTKKEVSNSTVDADNGASDFEAGQQFATELDQGEKQLGILSCIGLICNRMLGTGVFAVSSTIYTLCGSVGLALIMWAVGAIIAISGLYVYMEFGTAIPKNGGEKNYLEAIFRKPKFFITCMYAAYIFFLGWAAGNSINTAIMFLTAADTEVTKWNQRGIGVAVVFFAFLINSLNVKIGLYLQNILGIFKIGIVLFISITGWVALGGGLKDGYQSHNFRNAFEGTETATAYGIVNALYSVIWSFVGYSNVNYALGEVKNPVRTLKIAGPTSMVFLAIIYIFVNIAYFAVVPKDKLISSKLILAADFFDIVFGGQAKRAAAALVGLSALGNVLSVIFSQGRIIQQLGREGVLPFSNFFASSKPFNSPMVGLFQHFIVCTVTILAPPPGDAYLLVQNLISYPMNIINFAISAGLLWIYWQRRQGKIEWNPPIKAGVFVTGFFTLSNLYLIIAPYVPPSNGESVYSSMPYWIHCVIAWGIFFFGGVYYVVWAQLLPRWGHYKLVSKDVLGEDGFWRVKIAKVYDDTIGDVDTQEDGVIETNIIEHYKSEQEKSL"},{"created_at":"2011-05-27T17:53:23.000Z","updated_at":"2011-05-29T05:06:52.000Z","name":"S-adenosylmethionine synthase 2","uniprot_id":"P19358","uniprot_name":"METK2_YEAST","enzyme":true,"transporter":false,"gene_name":"SAM2","num_residues":384,"molecular_weight":"42255.5","theoretical_pi":"4.98","general_function":"Coenzyme transport and metabolism","specific_function":"Catalyzes the formation of S-adenosylmethionine from methionine and ATP","reactions":[{"id":1728,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2580,"direction":"\u003e","locations":"","altext":"ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.","export":false,"pw_reaction_id":null,"source":null},{"id":3761,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006285","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M23368","genbank_protein_id":"295659","gene_card_id":"SAM2","chromosome_location":"chromosome 4","locus":"YDR502C","synonyms":["AdoMet synthase 2","Methionine adenosyltransferase 2","MAT 2"],"enzyme_classes":["2.5.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" methionine adenosyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Process","description":" one-carbon metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"S-AdoMet_synt_C","identifier":"PF02773"},{"name":"S-AdoMet_synt_M","identifier":"PF02772"},{"name":"S-AdoMet_synt_N","identifier":"PF00438"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGTCCAAGAGCAAAACTTTCTTATTTACCTCTGAATCCGTCGGTGAAGGTCACCCAGACAAGATTTGTGACCAAGTTTCTGATGCTATTTTGGACGCTTGTTTAGAACAAGATCCATTCTCCAAGGTTGCCTGTGAAACAGCTGCCAAAACTGGTATGATTATGGTTTTCGGTGAAATTACCACCAAAGCTAGACTTGACTACCAACAAATAGTAAGAGATACCATCAAGAAGATTGGTTATGACGATTCTGCCAAGGGTTTCGACTACAAGACATGTAATGTTTTAGTAGCTATCGAACAACAATCTCCAGATATCGCTCAAGGTCTGCACTATGAAAAGAGCTTAGAAGACTTAGGTGCTGGTGACCAAGGTATAATGTTTGGTTACGCTACAGACGAAACTCCAGAAGGGTTACCATTGACCATTCTTTTGGCTCACAAATTGAACATGGCTATGGCAGATGCTAGAAGAGATGGTTCTCTCCCATGGTTGAGACCAGACACAAAGACTCAAGTCACTGTCGAATACGAAGACGACAATGGTAGATGGGTTCCAAAGAGGATAGATACCGTTGTTATTTCTGCTCAACATGCTGATGAAATTTCCACCGCTGACTTGAGAACTCAACTTCAAAAAGATATTGTTGAAAAGGTCATACCAAAGGATATGTTAGACGAAAATACCAAATATTTCATCCAACCATCCGGTAGATTCGTCATCGGTGGTCCTCAAGGTGACGCTGGTTTGACCGGTAGAAAGATTATTGTCGACGCTTACGGTGGTGCCTCATCCGTCGGTGGTGGTGCCTTCTCCGGTAAGGACTATTCCAAGGTCGATCGTTCCGCTGCTTACGCTGCTAGATGGGTTGCCAAGTCTCTAGTTGCCGCTGGTTTGTGTAAGAGAGTCCAAGTCCAATTTTCATATGCTATTGGTATTGCTGAACCATTGTCTTTACATGTGGACACCTATGGTACAGCTACAAAATCAGATGACGAAATCATTGAAATTATTAAGAAGAACTTCGACTTGAGACCAGGTGTGTTAGTAAAGGAATTAGATTTGGCTAGACCAATTTACTTACCAACCGCTTCTTATGGTCACTTCACTAATCAAGAGTACTCATGGGAAAAACCAAAGAAATTGGAATTTTAA","protein_sequence":"MSKSKTFLFTSESVGEGHPDKICDQVSDAILDACLEQDPFSKVACETAAKTGMIMVFGEITTKARLDYQQIVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGLHYEKSLEDLGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLPWLRPDTKTQVTVEYEDDNGRWVPKRIDTVVISAQHADEISTADLRTQLQKDIVEKVIPKDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDDEIIEIIKKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYSWEKPKKLEF"},{"created_at":"2011-06-14T19:34:27.000Z","updated_at":"2011-06-14T19:34:27.000Z","name":"Uncharacterized protein YCL033C","uniprot_id":"P25566","uniprot_name":"YCD3_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":168,"molecular_weight":"19278.80078","theoretical_pi":"9.26","general_function":"Involved in peptide-methionine-(S)-S-oxide reductase activity","specific_function":null,"reactions":[{"id":2856,"direction":"\u003e","locations":null,"altext":"Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X59720","genbank_protein_id":"5331","gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"},{"category":"Function","description":" peptide-methionine-(S)-S-oxide reductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"SelR","identifier":"PF01641"}],"pathways":[],"gene_sequence":"ATGAATAAGTGGAGCAGGCTGTACGTTATAACTGTACGCAGGACTTTTCCAGGGAGAAGAAACATTGTACTGACGCAGTACTGGAATAAGAGCAAGAAAATGAGTGACGAATCGAATGACGTGAAGTGGAACGATGCCCTGACACCATTGCAGCTGATGGTGCTGAGAGATAAGGCCACTGAAAGGCCCAACACCGGTGCGTATTTACACACCAACGAGTCCGGTGTCTACCATTGTGCCAACTGCGACAGACCGTTGTATTCGAGCAAGGCCAAGTTCGACGCTCGTTGTGGATGGCCCGCATTCTACGAAGAGGTATCCCCTGGAGCCATCACATATCATCGTGACAATTCTTTAATGCCTGCGAGGGTGGAGATATGTTGTGCAAGGTGTGGTGGACACTTGGGACATGTGTTTGAAGGTGAAGGCTGGAAACAGTTGCTAAACTTGCCCAAGGACACCAGACACTGTGTGAACAGTGCGTCTTTAAACCTCAAGAAGGATTAA","protein_sequence":"MNKWSRLYVITVRRTFPGRRNIVLTQYWNKSKKMSDESNDVKWNDALTPLQLMVLRDKATERPNTGAYLHTNESGVYHCANCDRPLYSSKAKFDARCGWPAFYEEVSPGAITYHRDNSLMPARVEICCARCGGHLGHVFEGEGWKQLLNLPKDTRHCVNSASLNLKKD"}]}