{"ymdb_id":"YMDB00338","created_at":"2011-05-29T18:07:32.000Z","updated_at":"2016-10-18T17:11:27.000Z","name":"Succinic acid","cas":"110-15-6","state":"Solid","melting_point":"185-188 oC","description":"Succinic acid is a dicarboxylic acid. The anion, succinate, is a component of the citric acid cycle.","experimental_water_solubility":"83.2 mg/mL at 25 oC [YALKOWSKY,SH \u0026 HE,Y (2003)]","experimental_logp_hydrophobicity":"-0.59 [HANSCH,C ET AL. (1995)]","location":"extracellular;mitochondrion;cytoplasm","synthesis_reference":"Berglund, Kris Arvid; Andersson, Christian; Rova, Ulrika.  Process for the production of succinic acid.    PCT Int. Appl.  (2007),     30pp. ","chebi_id":"15741","hmdb_id":"HMDB00254","kegg_id":"C00042","pubchem_id":"1110","cs_id":"1078","foodb_id":null,"wikipedia_link":"Succinic_acid","biocyc_id":"SUC","iupac":"butanedioic acid","traditional_iupac":"succinic acid","logp":"-0.3984829673333332","pka":"5.6869121792916","alogps_solubility":"2.11e+02 g/l","alogps_logp":"-0.53","alogps_logs":"0.25","acceptor_count":"4","donor_count":"2","rotatable_bond_count":"3","polar_surface_area":"74.6","refractivity":"23.537","polarizability":"10.141334051490146","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":null,"pka_strongest_acidic":"3.5541665109763474","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["1,2-Ethanedicarboxylate","1,2-Ethanedicarboxylic acid","1,4-Butanedioate","1,4-Butanedioic acid","Amber acid","Asuccin","butanedioic acid, ion(2-)","Dihydrofumarate","Dihydrofumaric acid","Katasuccin","Succinate","Wormwood acid"],"pathways":[{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Phenylalanine metabolism","kegg_map_id":"00360"},{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"4-aminobutanoate degradation","kegg_map_id":null},{"name":"Citric Acid Cycle","kegg_map_id":null},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"Glutamate Metabolism","kegg_map_id":null},{"name":"Glyoxylate cycle","kegg_map_id":null},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Sulfur metabolism","kegg_map_id":"00920"},{"name":"TCA Cycle","kegg_map_id":null}],"growth_conditions":[{"growth_media":"hops, malted barley","concentration":"577.0","concentration_units":"\u0026#181;M","error":"69.0"},{"growth_media":"YEB media with 0.5 mM glucose","concentration":"600.0","concentration_units":"\u0026#181;M","error":"30.0"},{"growth_media":"Glucose limited aerobic culture","concentration":"4.0","concentration_units":"umol/g DW","error":"0.0"},{"growth_media":"Synthetic medium ","concentration":"1945.0","concentration_units":"uM","error":"0.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":16584566,"citation":"Schwartz, J. M., Kanehisa, M. (2006). \"Quantitative elementary mode analysis of metabolic pathways: the example of yeast glycolysis.\" BMC Bioinformatics 7:186."},{"pubmed_id":11092862,"citation":"Luttik, M. A., Kotter, P., Salomons, F. A., van der Klei, I. J., van Dijken, J. P., Pronk, J. T. (2000). \"The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism.\" J Bacteriol 182:7007-7013."},{"pubmed_id":3933486,"citation":"Takada, Y., Noguchi, T. (1985). \"Characteristics of alanine: glyoxylate aminotransferase from Saccharomyces cerevisiae, a regulatory enzyme in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates.\" Biochem J 231:157-163."},{"pubmed_id":10224250,"citation":"Przybyla-Zawislak, B., Gadde, D. M., Ducharme, K., McCammon, M. T. (1999). \"Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes.\" Genetics 152:153-166."},{"pubmed_id":16448171,"citation":"Almeida, C., Duarte, I. F., Barros, A., Rodrigues, J., Spraul, M., Gil, A. M. (2006). \"Composition of beer by 1H NMR spectroscopy: effects of brewing site and date of production.\" J Agric Food Chem 54:700-706."},{"pubmed_id":16332871,"citation":"Singh, J., Kumar, D., Ramakrishnan, N., Singhal, V., Jervis, J., Garst, J. F., Slaughter, S. M., DeSantis, A. M., Potts, M., Helm, R. F. (2005). \"Transcriptional response of Saccharomyces cerevisiae to desiccation and rehydration.\" Appl Environ Microbiol 71:8752-8763."},{"pubmed_id":9395087,"citation":"Palmieri, L., Lasorsa, F. M., De Palma, A., Palmieri, F., Runswick, M. J., Walker, J. E. (1997). \"Identification of the yeast ACR1 gene product as a succinate-fumarate transporter essential for growth on ethanol or acetate.\" FEBS Lett 417:114-118."},{"pubmed_id":9874242,"citation":"Przybyla-Zawislak, B., Dennis, R. A., Zakharkin, S. O., McCammon, M. T. (1998). \"Genes of succinyl-CoA ligase from Saccharomyces cerevisiae.\" Eur J Biochem 258:736-743."},{"pubmed_id":10482536,"citation":"Hogan, D. A., Auchtung, T. A., Hausinger, R. P. (1999). \"Cloning and characterization of a sulfonate/alpha-ketoglutarate dioxygenase from Saccharomyces cerevisiae.\" J Bacteriol 181:5876-5879."},{"pubmed_id":1409592,"citation":"Nagy, M., Lacroute, F., Thomas, D. (1992). \"Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts.\" Proc Natl Acad Sci U S A 89:8966-8970."},{"pubmed_id":11031268,"citation":"Coleman, S. T., Fang, T. K., Rovinsky, S. A., Turano, F. J., Moye-Rowley, W. S. (2001). \"Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae.\" J Biol Chem 276:244-250."},{"pubmed_id":9587404,"citation":"Muratsubaki, H., Enomoto, K. (1998). \"One of the fumarate reductase isoenzymes from Saccharomyces cerevisiae is encoded by the OSM1 gene.\" Arch Biochem Biophys 352:175-181."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T20:39:30.000Z","updated_at":"2011-05-27T14:56:01.000Z","name":"Isocitrate lyase","uniprot_id":"P28240","uniprot_name":"ACEA_YEAST","enzyme":true,"transporter":false,"gene_name":"ICL1","num_residues":557,"molecular_weight":"62408.30078","theoretical_pi":"6.37","general_function":"Involved in isocitrate lyase activity","specific_function":"Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate","reactions":[{"id":1677,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2333,"direction":"\u003e","locations":"Cytoplasm","altext":"Isocitrate = succinate + glyoxylate.","export":false,"pw_reaction_id":null,"source":null},{"id":4170,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006468","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U18813","genbank_protein_id":"603301","gene_card_id":"ICL1","chromosome_location":"chromosome 5","locus":"YER065C","synonyms":["ICL","Threo-D(S)-isocitrate glyoxylate-lyase","Isocitrase","Isocitratase"],"enzyme_classes":["4.1.3.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" isocitrate lyase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"}],"pfams":[{"name":"ICL","identifier":"PF00463"}],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"Glyoxylate cycle","kegg_map_id":null}],"gene_sequence":"ATGCCTATCCCCGTTGGAAATACGAAGAACGATTTTGCAGCTTTACAAGCAAAACTAGATGCAGATGCTGCCGAAATTGAGAAATGGTGGTCTGACTCACGTTGGAGTAAGACTAAGAGAAATTATTCAGCCAGAGATATTGCTGTTAGACGCGGGACATTCCCACCAATCGAATACCCATCTTCGGTCATGGCCAGAAAATTATTCAAGGTATTAGAGAAGCATCACAATGAGGGTACAGTCTCTAAAACTTTCGGTGCCCTAGATCCTGTCCAGATTTCTCAAATGGCAAAATACTTAGACACAATCTATATTTCTGGTTGGCAGTGTTCATCAACTGCTTCCACCTCAAATGAACCTGGTCCAGACTTAGCTGATTATCCAATGGACACCGTTCCAAACAAAGTGGAACATTTGTTCAAGGCCCAATTGTTTCACGACAGAAAACAACTAGAGGCACGGTCAAAGGCTAAATCTCAGGAAGAACTCGATGAGATGGGTGCCCCAATTGACTACCTAACACCAATTGTCGCTGATGCAGACGCAGGCCACGGCGGTTTAACCGCAGTCTTCAAATTGACCAAGATGTTCATTGAGCGTGGTGCTGCTGGGATCCACATGGAAGACCAGACATCTACAAATAAGAAATGTGGGCATATGGCAGGAAGATGTGTTATACCCGTTCAGGAACATGTTAACAGATTGGTGACTATTAGAATGTGTGCTGATATCATGCATTCTGACTTAATTGTCGTTGCTAGGACTGATTCAGAAGCAGCCACTTTGATTAGCTCAACCATCGATACCAGAGATCATTATTTCATTGTCGGTGCCACCAATCCAAATATCGAGCCATTTGCCGAAGTTTTAAATGATGCCATCATGAGTGGTGCATCAGGACAAGAACTAGCTGACATTGAACAAAAATGGTGTAGAGACGCTGGACTCAAGTTATTCCATGAAGCCGTCATTGATGAAATTGAAAGATCAGCCCTGTCAAATAAGCAAGAATTGATTAAGAAATTCACCTCTAAAGTGGGTCCATTGACTGAAACATCCCACAGAGAAGCCAAGAAGCTCGCTAAAGAAATTCTTGGCCACGAAATTTTCTTCGACTGGGAGCTACCACGCGTAAGGGAAGGGTTGTACCGTTACAGAGGTGGGACGCAATGTTCTATCATGAGGGCCCGTGCATTTGCTCCATATGCTGATTTGGTATGGATGGAATCTAACTACCCAGACTTCCAACAGGCCAAGGAGTTTGCAGAAGGTGTTAAAGAGAAATTCCCTGACCAATGGCTAGCTTACAACTTGTCTCCATCCTTTAACTGGCCAAAAGCCATGTCCGTTGATGAACAACACACCTTCATCCAAAGGCTGGGTGATCTAGGTTACATCTGGCAATTTATCACATTGGCCGGTTTACACACTAACGCTTTAGCTGTCCATAACTTCTCTCGTGACTTTGCCAAGGATGGGATGAAAGCTTATGCCCAGAATGTTCAGCAGAGGGAAATGGACGATGGTGTTGATGTGTTGAAACATCAAAAATGGTCTGGTGCGGAGTACATCGATGGGTTATTGAAGTTAGCTCAAGGTGGTGTTAGCGCAACAGCTGCTATGGGAACCGGTGTCACAGAAGATCAATTCAAAGAAAATGGCGTAAAGAAATAG","protein_sequence":"MPIPVGNTKNDFAALQAKLDADAAEIEKWWSDSRWSKTKRNYSARDIAVRRGTFPPIEYPSSVMARKLFKVLEKHHNEGTVSKTFGALDPVQISQMAKYLDTIYISGWQCSSTASTSNEPGPDLADYPMDTVPNKVEHLFKAQLFHDRKQLEARSKAKSQEELDEMGAPIDYLTPIVADADAGHGGLTAVFKLTKMFIERGAAGIHMEDQTSTNKKCGHMAGRCVIPVQEHVNRLVTIRMCADIMHSDLIVVARTDSEAATLISSTIDTRDHYFIVGATNPNIEPFAEVLNDAIMSGASGQELADIEQKWCRDAGLKLFHEAVIDEIERSALSNKQELIKKFTSKVGPLTETSHREAKKLAKEILGHEIFFDWELPRVREGLYRYRGGTQCSIMRARAFAPYADLVWMESNYPDFQQAKEFAEGVKEKFPDQWLAYNLSPSFNWPKAMSVDEQHTFIQRLGDLGYIWQFITLAGLHTNALAVHNFSRDFAKDGMKAYAQNVQQREMDDGVDVLKHQKWSGAEYIDGLLKLAQGGVSATAAMGTGVTEDQFKENGVKK"},{"created_at":"2011-05-24T21:16:20.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Succinyl-CoA ligase [ADP-forming] subunit alpha, mitochondrial","uniprot_id":"P53598","uniprot_name":"SUCA_YEAST","enzyme":true,"transporter":false,"gene_name":"LSC1","num_residues":329,"molecular_weight":"35032.19922","theoretical_pi":"8.76","general_function":"Involved in catalytic activity","specific_function":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA","reactions":[{"id":2376,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":3700,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003283","source":"Smpdb"},{"id":3701,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006825","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"X94335","genbank_protein_id":"1164984","gene_card_id":"LSC1","chromosome_location":"chromosome 15","locus":"YOR142W","synonyms":["Succinyl-CoA synthetase subunit alpha","SCS-alpha"],"enzyme_classes":["6.2.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ATP citrate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer"},{"category":"Function","description":" ligase activity, forming carbon-sulfur bonds"},{"category":"Function","description":" CoA-ligase activity"},{"category":"Function","description":" succinate-CoA ligase activity"},{"category":"Function","description":" succinate-CoA ligase (ADP-forming) activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"CoA_binding","identifier":"PF02629"},{"name":"Ligase_CoA","identifier":"PF00549"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTTAAGATCTACCGTTTCAAAAGCTTCTCTCAAAATTTGTCGTCACTTTCACAGAGAATCTATTCCTTACGATAAGACGATCAAAAATTTGCTGCTTCCCAAGGACACCAAGGTGATCTTTCAGGGGTTCACAGGTAAACAAGGTACTTTTCATGCCAGCATCTCTCAAGAATATGGTACAAATGTTGTGGGTGGTACGAACCCAAAAAAGGCGGGTCAAACACATTTAGGCCAACCTGTCTTTGCCTCTGTGAAGGACGCGATTAAGGAGACTGGAGCCACTGCCAGTGCCATCTTTGTTCCTCCACCGATCGCAGCTGCTGCCATTAAAGAATCTATTGAAGCTGAAATTCCGTTAGCTGTATGTATCACTGAAGGTATTCCTCAACATGACATGTTATACATTGCAGAAATGTTGCAGACACAAGATAAAACAAGATTAGTTGGGCCCAACTGCCCTGGTATCATTAACCCAGCAACAAAGGTAAGAATTGGTATCCAGCCCCCAAAAATTTTTCAAGCTGGTAAAATCGGTATTATTTCCAGATCGGGAACTTTGACATACGAAGCTGTTCAGCAAACTACAAAAACTGACCTTGGTCAATCACTGGTTATTGGTATGGGTGGTGATGCTTTTCCCGGTACTGATTTTATTGACGCCTTGAAATTATTTCTAGAAGATGAAACTACAGAAGGTATTATTATGTTAGGTGAAATAGGTGGTAAGGCCGAAATCGAAGCTGCTCAATTTCTCAAAGAATACAACTTTAGCAGGAGTAAGCCGATGCCGGTGGCATCTTTCATCGCAGGAACTGTTGCTGGTCAAATGAAAGGTGTTAGAATGGGTCACTCCGGTGCAATTGTAGAAGGATCTGGAACTGATGCAGAATCCAAAAAACAAGCTTTGAGAGATGTTGGTGTTGCCGTCGTTGAATCTCCAGGTTACTTAGGTCAAGCTTTACTGGATCAATTTGCCAAATTTAAATGA","protein_sequence":"MLRSTVSKASLKICRHFHRESIPYDKTIKNLLLPKDTKVIFQGFTGKQGTFHASISQEYGTNVVGGTNPKKAGQTHLGQPVFASVKDAIKETGATASAIFVPPPIAAAAIKESIEAEIPLAVCITEGIPQHDMLYIAEMLQTQDKTRLVGPNCPGIINPATKVRIGIQPPKIFQAGKIGIISRSGTLTYEAVQQTTKTDLGQSLVIGMGGDAFPGTDFIDALKLFLEDETTEGIIMLGEIGGKAEIEAAQFLKEYNFSRSKPMPVASFIAGTVAGQMKGVRMGHSGAIVEGSGTDAESKKQALRDVGVAVVESPGYLGQALLDQFAKFK"},{"created_at":"2011-05-26T16:17:09.000Z","updated_at":"2011-05-27T15:00:59.000Z","name":"Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial","uniprot_id":"P53312","uniprot_name":"SUCB_YEAST","enzyme":true,"transporter":false,"gene_name":"LSC2","num_residues":427,"molecular_weight":"46900.30078","theoretical_pi":"7.56","general_function":"Involved in catalytic activity","specific_function":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA","reactions":[{"id":2376,"direction":"\u003e","locations":"Mitochondrion","altext":"ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.","export":false,"pw_reaction_id":null,"source":null},{"id":3700,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003283","source":"Smpdb"},{"id":3701,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006825","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"Z73029","genbank_protein_id":"1323442","gene_card_id":"LSC2","chromosome_location":"chromosome 7","locus":"YGR244C","synonyms":["Succinyl-CoA synthetase beta chain","SCS-beta"],"enzyme_classes":["6.2.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Ligase_CoA","identifier":"PF00549"},{"name":"ATP-grasp_2","identifier":"PF08442"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Propanoate metabolism","kegg_map_id":"00640"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTACTCAAGAAAATCCTTATCCCTAATTTCAAAGTGTGGGCAATTAAGCAGGCTAAACGCGCAAGCTGCTTTACAAGCAAGGAGACACTTGTCAATTCATGAATACAGGTCAGCTCAGTTATTGAGGGAATACGGTATTGGTACTCCAGAAGGATTTCCAGCGTTCACTCCCGAAGAGGCTTTCGAAGCAGCCAAGAAATTAAACACTAACAAACTGGTCATCAAGGCGCAGGCATTGACCGGAGGTAGAGGTAAAGGTCACTTCGACACCGGTTACAAAAGCGGTGTTCACATGATCGAAAGTCCTCAGCAGGCAGAGGATGTTGCAAAAGAAATGCTCAATCATAACCTGATTACTAAACAGACGGGAATAGCGGGGAAGCCAGTATCTGCTGTATATATAGTGAAAAGAGTAGATACAAAGCATGAAGCTTATTTATCTATTCTAATGGACAGACAAACCAAGAAACCGATGATCATTGCGTCCAGTCAAGGTGGTATGAATATTGAAGAGGTGGCTGAGAGAACCCCAGATGCTATAAAGAAATTTTCAATTGAAACTTCAAAGGGATTGAGCCCACAAATGGCCAAGGATGTTGCCAAGAGTCTCGGTTTCAGTCCCGATGCACAAGACGAGGCAGCAAAAGCTGTTTCCAATTTGTATAAAATATTCATGGAAAGGGATGCTACACAAGTGGAGATTAACCCTTTGAGTGAAATTGAACATGATCCAACCCACAAAATCATGTGTACAGACGCCAAATTTGGGTTTGATGATAACGCATCATTCAGACAGGAAAAGATATATTCCTGGAGGGACTTATCACAAGAAGATCCTGATGAAGTTAAGGCAAAGAAGTATGATTTGAATTTTGTTAAGTTGAAGGGTAACATTGGATGTTTAGTCAATGGTGCTGGTTTGGCTATGGCTACTATGGATGTCATCAAATTAAATGGAGGCGATCCTGCGAACTTTTTGGATTGTGGTGGTGGTGCCACCCCTGAGACCATCAAACAAGGTTTCGAATTGATCTTATCCAATAAGAACGTAGATGCAATTTTCGTCAATATTTTCGGCGGTATCGTAAGATGTGACTATGTTGCCCTGGGGCTGGTAGAAGCCGCCAGAGAACTAGAAGTTAGGGTCCCCATTGTGGCACGTTTGCAAGGTACCAAAGTAGAAGAAGGCCGCGACATTATCAATAAGTCAGGCGTGAAGATTTATTCGTTTGATGAATTAGATCCTGCTGCTAAAAAGGTCGTTGAATTGACCCAAAATTAA","protein_sequence":"MYSRKSLSLISKCGQLSRLNAQAALQARRHLSIHEYRSAQLLREYGIGTPEGFPAFTPEEAFEAAKKLNTNKLVIKAQALTGGRGKGHFDTGYKSGVHMIESPQQAEDVAKEMLNHNLITKQTGIAGKPVSAVYIVKRVDTKHEAYLSILMDRQTKKPMIIASSQGGMNIEEVAERTPDAIKKFSIETSKGLSPQMAKDVAKSLGFSPDAQDEAAKAVSNLYKIFMERDATQVEINPLSEIEHDPTHKIMCTDAKFGFDDNASFRQEKIYSWRDLSQEDPDEVKAKKYDLNFVKLKGNIGCLVNGAGLAMATMDVIKLNGGDPANFLDCGGGATPETIKQGFELILSNKNVDAIFVNIFGGIVRCDYVALGLVEAARELEVRVPIVARLQGTKVEEGRDIINKSGVKIYSFDELDPAAKKVVELTQN"},{"created_at":"2011-05-26T16:29:03.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"Putative cystathionine gamma-synthase YML082W","uniprot_id":"Q04533","uniprot_name":"METX_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":649,"molecular_weight":"74312.70313","theoretical_pi":"5.02","general_function":"Involved in pyridoxal phosphate binding","specific_function":"O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate","reactions":[{"id":1421,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1801,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2421,"direction":"\u003e","locations":"Cytoplasm. 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Cytoplasm","genbank_gene_id":"U18779","genbank_protein_id":"603632","gene_card_id":null,"chromosome_location":null,"locus":"YEL047C","synonyms":["FAD-dependent oxidoreductase FRDS","NADH","NADH-dependent fumarate reductase"],"enzyme_classes":["1.3.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" succinate dehydrogenase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"}],"pathways":[{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTCTCTCTCTCCCGTTGTTGTTATTGGAACCGGTTTGGCCGGGCTGGCTGCTGCCAATGAATTGGTTAACAAGTATAACATCCCTGTAACCATCCTCGAAAAGGCTTCCTCGATCGGTGGGAACTCTATCAAGGCCTCCAGTGGTATTAACGGTGCTTGCACCGAGACTCAACGTCACTTCCACATCGAGGACTCCCCACGCTTATTTGAAGATGACACCATCAAGTCTGCTAAAGGTAAAGGTGTCCAAGAATTAATGGCTAAGTTGGCCAATGATTCTCCCCTGGCTATTGAATGGTTGAAAAACGAATTTGATTTGAAATTGGACCTATTGGCTCAATTGGGTGGCCACTCTGTGGCAAGAACTCACAGATCGTCTGGGAAGTTGCCTCCAGGTTTCGAAATTGTTTCTGCCTTATCTAACAATTTGAAGAAATTAGCTGAGACTAAACCAGAGTTAGTTAAGATTAACTTAGACAGTAAAGTCGTAGACATCCATGAAAAGGATGGCTCCATTTCTGCTGTAGTGTACGAGGACAAGAATGGCGAAAAGCACATGGTGAGTGCTAACGATGTCGTTTTTTGTTCTGGAGGGTTTGGCTTTTCTAAGGAAATGCTTAAAGAATACGCACCCGAACTGGTGAACTTGCCAACAACAAACGGGCAACAAACAACTGGTGATGGTCAAAGGCTTCTGCAGAAGTTAGGCGCTGATCTGATTGACATGGACCAAATTCAAGTTCATCCAACTGGGTTCATTGATCCAAATGACCGTAGCTCAAGCTGGAAATTCTTGGCTGCCGAATCCTTAAGAGGTCTTGGTGGTATCCTATTAAACCCTATTACCGGTAGAAGATTTGTCAACGAATTGACCACAAGAGATGTAGTCACTGCAGCTATTCAAAAGGTTTGTCCTCAAGAGGATAACAGAGCACTATTGGTTATGGGCGAAAAAATGTACACAGATTTGAAGAATAATTTAGATTTTTACATGTTCAAGAAACTTGTACAGAAATTGACATTATCTCAAGTTGTTTCTGAATATAATTTACCAATCACTGTCGCCCAATTATGCGAGGAATTGCAAACATACTCTTCCTTCACTACCAAGGCTGATCCGTTGGGACGTACCGTTATTCTCAACGAATTTGGCTCTGACGTTACTCCAGAAACTGTGGTTTTTATTGGTGAAGTAACACCGGTTGTCCATTTCACCATGGGTGGTGCTAGAATCAATGTCAAGGCTCAAGTCATTGGCAAGAACGACGAAAGGCTACTAAAAGGCCTGTACGCGGCCGGTGAAGTTTCTGGCGGTGTTCATGGCGCCAATAGGTTGGGTGGTTCAAGTTTGTTAGAATGCGTTGTCTTTGGGAGAACCGCAGCTGAATCTATTGCCAATGACCGCAAGTAA","protein_sequence":"MSLSPVVVIGTGLAGLAAANELVNKYNIPVTILEKASSIGGNSIKASSGINGACTETQRHFHIEDSPRLFEDDTIKSAKGKGVQELMAKLANDSPLAIEWLKNEFDLKLDLLAQLGGHSVARTHRSSGKLPPGFEIVSALSNNLKKLAETKPELVKINLDSKVVDIHEKDGSISAVVYEDKNGEKHMVSANDVVFCSGGFGFSKEMLKEYAPELVNLPTTNGQQTTGDGQRLLQKLGADLIDMDQIQVHPTGFIDPNDRSSSWKFLAAESLRGLGGILLNPITGRRFVNELTTRDVVTAAIQKVCPQEDNRALLVMGEKMYTDLKNNLDFYMFKKLVQKLTLSQVVSEYNLPITVAQLCEELQTYSSFTTKADPLGRTVILNEFGSDVTPETVVFIGEVTPVVHFTMGGARINVKAQVIGKNDERLLKGLYAAGEVSGGVHGANRLGGSSLLECVVFGRTAAESIANDRK"},{"created_at":"2011-05-26T17:57:08.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Osmotic growth protein 1","uniprot_id":"P21375","uniprot_name":"OSM1_YEAST","enzyme":true,"transporter":false,"gene_name":"OSM1","num_residues":501,"molecular_weight":"55064.80078","theoretical_pi":"9.51","general_function":"Involved in electron carrier activity","specific_function":"Could be a fumarate reductase","reactions":[{"id":1555,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1556,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":3732,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006258","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm (Probable)","genbank_gene_id":"L26347","genbank_protein_id":"695798","gene_card_id":"OSM1","chromosome_location":"chromosome 10","locus":"YJR051W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" succinate dehydrogenase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"}],"pathways":[],"gene_sequence":"ATGATTAGATCTGTGAGAAGGGTTTTCATTTACGTCTCAATATTCGTATTGATAATAGTTTTGAAAAGAACATTAAGTGGCACAGATCAAACGTCAATGAAACAACCAGTGGTGGTCATTGGCTCTGGTTTGGCAGGCTTAACCACAAGTAATCGTCTCATTAGTAAATACAGAATTCCTGTTGTGCTTTTGGATAAGGCGGCTTCTATTGGTGGGAATTCTATAAAGGCTTCTAGTGGTATTAATGGTGCTCACACAGACACTCAACAAAATTTAAAGGTAATGGACACTCCCGAATTGTTTTTGAAAGATACTTTGCATTCGGCTAAAGGCAGAGGGGTTCCATCACTGATGGATAAGTTGACTAAGGAATCCAAGAGTGCTATCAGGTGGTTGCAAACAGAATTCGATTTGAAATTAGACCTCCTTGCGCAATTGGGCGGTCACTCTGTTCCAAGGACCCATAGATCTTCTGGCAAATTACCACCAGGTTTTGAAATCGTGCAAGCGTTATCAAAAAAACTAAAGGATATCTCTTCCAAAGATTCCAATCTCGTGCAGATTATGCTAAACAGTGAAGTAGTGGATATCGAGCTTGATAATCAAGGTCATGTTACTGGTGTAGTATATATGGACGAGAACGGAAACCGTAAAATCATGAAGTCACACCATGTCGTGTTTTGCTCAGGTGGATTTGGTTACTCTAAGGAAATGTTGAAAGAGTACTCACCAAATTTGATTCACTTGCCAACTACTAATGGCAAACAGACTACAGGTGATGGTCAAAAAATCCTTTCAAAGTTGGGTGCCGAATTGATTGATATGGATCAAGTGCAGGTACACCCTACCGGCTTCATTGATCCAAATGACCGTGAAAATAACTGGAAGTTTTTGGCTGCAGAGGCATTGAGGGGTTTAGGCGGCATCTTATTGCATCCCACCACTGGAAGAAGGTTTACAAATGAATTGAGCACCAGAGATACAGTAACCATGGAAATACAGTCTAAATGTCCGAAAAATGATAATAGAGCACTTTTGGTAATGAGCGACAAAGTCTACGAGAACTATACGAATAACATAAACTTTTATATGTCCAAAAACTTAATCAAAAAAGTGTCAATCAACGATCTGATCCGACAATATGACCTACAAACTACAGCTTCTGAACTGGTAACTGAACTGAAGAGCTATTCCGATGTTAATACTAAGGATACGTTTGATAGGCCATTGATTATCAATGCCTTTGATAAAGATATTTCGACTGAATCAACTGTTTATGTTGGGGAAGTTACACCAGTTGTTCATTTCACAATGGGTGGTGTGAAAATTAATGAGAAATCTCAGGTAATTAAGAAAAATTCGGAAAGCGTTCTATCTAATGGGATATTTGCTGCTGGTGAAGTTTCGGGTGGTGTTCATGGAGCCAACAGATTGGGTGGATCTAGTTTGTTAGAGTGTGTTGTCTTTGGAAAGACAGCTGCGGATAACATAGCAAAATTGTACTGA","protein_sequence":"MIRSVRRVFIYVSIFVLIIVLKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAKLY"},{"created_at":"2011-05-26T18:04:17.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial","uniprot_id":"Q00711","uniprot_name":"DHSA_YEAST","enzyme":true,"transporter":false,"gene_name":"SDH1","num_residues":640,"molecular_weight":"70228.79688","theoretical_pi":"7.53","general_function":"Involved in electron carrier activity","specific_function":"Catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4","reactions":[{"id":2505,"direction":"\u003e","locations":" Matrix side; Peripheral membrane protein;Mitochondrion inner membrane","altext":"Succinate + ubiquinone = fumarate + ubiquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"M86746","genbank_protein_id":"172557","gene_card_id":"SDH1","chromosome_location":"chromosome 11","locus":"YKL148C","synonyms":["Flavoprotein subunit of complex II","FP"],"enzyme_classes":["1.3.5.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" generation of precursor metabolites and energy"},{"category":"Process","description":" electron transport chain"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"},{"name":"Succ_DH_flav_C","identifier":"PF02910"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"}],"gene_sequence":"ATGCTATCGCTAAAAAAATCAGCGCTCTCCAAGTTGACTTTGCTCAGAAACACAAGAACATTTACATCGTCAGCTTTGGTGCGCCAAACGCAGGGCTCTGTAAACGGTTCCGCGTCCAGATCTGCAGACGGGAAGTACCACATAATAGATCACGAGTATGACTGTGTGGTAATCGGTGCCGGTGGTGCCGGCCTTAGAGCGGCCTTTGGTCTTGCCGAGGCGGGCTACAAGACTGCTTGTATATCCAAGCTTTTCCCCACCAGATCCCACACTGTTGCTGCTCAGGGTGGTATCAATGCCGCTCTGGGAAATATGCACAAGGATAACTGGAAATGGCATATGTACGATACTGTGAAAGGATCTGATTGGCTAGGTGACCAGGACTCCATCCATTACATGACCAGGGAAGCGCCCAAATCGATCATTGAACTGGAACACTATGGTGTTCCTTTTTCAAGAACTGAAAACGGTAAGATCTACCAAAGAGCCTTTGGTGGTCAGACCAAGGAGTACGGTAAGGGTGCTCAGGCCTATAGAACATGCGCTGTCGCAGACAGGACAGGACATGCTCTTTTACACACGCTTTATGGCCAAGCTTTAAGACATGACACACATTTCTTTATTGAGTACTTTGCCCTCGATCTGTTGACCCATAATGGCGAGGTCGTTGGTGTCATCGCTTATAATCAGGAAGACGGTACCATCCACAGATTCAGAGCACACAAGACCATTATTGCCACTGGTGGCTATGGTAGAGCATACTTCTCTTGTACCTCTGCTCACACATGTACGGGTGACGGTAATGCCATGGTTTCGCGTGCTGGTTTCCCCTTGCAAGATTTAGAGTTTGTTCAATTCCATCCTTCAGGTATATATGGGTCTGGTTGCTTAATCACTGAAGGTGCTCGTGGTGAAGGTGGTTTTTTGGTTAATTCTGAAGGTGAAAGATTCATGGAACGTTACGCTCCTACGGCCAAGGATCTAGCTTGTAGAGATGTCGTTTCCAGAGCAATCACCATGGAGATCAGAGAAGGCAGAGGTGTTGGTAAGAAAAAGGACCACATGTACTTACAATTGAGCCATCTACCTCCGGAAGTTCTAAAGGAAAGATTGCCAGGTATCTCTGAAACAGCAGCCATTTTTGCTGGTGTAGACGTCACTAAGGAACCTATTCCCATTATTCCTACCGTCCACTATAACATGGGTGGTATTCCCACGAAGTGGAATGGTGAGGCATTAACCATTGATGAAGAAACTGGCGAAGACAAGGTTATTCCCGGTTTAATGGCTTGTGGTGAAGCCGCTTGTGTTTCTGTCCATGGTGCCAATAGATTAGGTGCCAATTCCTTGTTGGATCTTGTTGTCTTTGGTCGTGCTGTTGCCCATACGGTTGCTGACACTTTACAGCCTGGGTTGCCACACAAACCACTACCTTCTGATTTGGGTAAAGAATCCATCGCAAACTTGGATAAACTAAGAAATGCTAATGGTTCAAGATCTACGGCAGAAATTAGAATGAATATGAAACAAACTATGCAAAAGGATGTTTCCGTCTTTAGAACACAATCATCTTTAGATGAAGGTGTTCGGAACATTACTGCAGTAGAGAAGACCTTTGATGATGTGAAGACGACCGATAGATCAATGATCTGGAATTCTGACTTGGTTGAAACTCTGGAGCTACAGAACTTATTAACCTGTGCCTCCCAAACAGCTGTTTCCGCTGCTAATAGAAAGGAATCCCGTGGTGCTCATGCAAGAGAGGATTATCCAAATAGAGATGACGAACATTGGATGAAGCATACATTATCCTGGCAAAAGGACGTCGCTGCCCCAGTGACTTTGAAATACAGAAGGGTTATCGATCACACTTTGGACGAAAAGGAATGTCCTTCCGTACCTCCAACTGTAAGAGCCTACTAA","protein_sequence":"MLSLKKSALSKLTLLRNTRTFTSSALVRQTQGSVNGSASRSADGKYHIIDHEYDCVVIGAGGAGLRAAFGLAEAGYKTACISKLFPTRSHTVAAQGGINAALGNMHKDNWKWHMYDTVKGSDWLGDQDSIHYMTREAPKSIIELEHYGVPFSRTENGKIYQRAFGGQTKEYGKGAQAYRTCAVADRTGHALLHTLYGQALRHDTHFFIEYFALDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTIIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLQDLEFVQFHPSGIYGSGCLITEGARGEGGFLVNSEGERFMERYAPTAKDLACRDVVSRAITMEIREGRGVGKKKDHMYLQLSHLPPEVLKERLPGISETAAIFAGVDVTKEPIPIIPTVHYNMGGIPTKWNGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVAHTVADTLQPGLPHKPLPSDLGKESIANLDKLRNANGSRSTAEIRMNMKQTMQKDVSVFRTQSSLDEGVRNITAVEKTFDDVKTTDRSMIWNSDLVETLELQNLLTCASQTAVSAANRKESRGAHAREDYPNRDDEHWMKHTLSWQKDVAAPVTLKYRRVIDHTLDEKECPSVPPTVRAY"},{"created_at":"2011-05-26T18:04:53.000Z","updated_at":"2011-05-26T18:04:53.000Z","name":"Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial","uniprot_id":"P47052","uniprot_name":"DHSX_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":634,"molecular_weight":"69382.0","theoretical_pi":"7.4","general_function":"Involved in electron carrier activity","specific_function":"Probable minor catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Probably forms a catalytic dimer with SDH2. Electrons flow from succinate to the FAD bound to the catalytic subunit, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4","reactions":[{"id":2505,"direction":"\u003e","locations":" Matrix side; Peripheral membrane protein;Mitochondrion inner membrane","altext":"Succinate + ubiquinone = fumarate + ubiquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"Z49320","genbank_protein_id":"1008175","gene_card_id":null,"chromosome_location":null,"locus":"YJL045W","synonyms":["Flavoprotein subunit of complex II","FP","SDH1b"],"enzyme_classes":["1.3.5.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" generation of precursor metabolites and energy"},{"category":"Process","description":" electron transport chain"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"},{"name":"Succ_DH_flav_C","identifier":"PF02910"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"}],"gene_sequence":"ATGTTATCTTTGAAAAAAGGAATAACAAAATCATACATCTTGCAAAGAACTTTCACTTCTTCCTCTGTTGTTCGTCAAATTGGGGAAGTGAAATCTGAATCGAAACCGCCGGCCAAATATCATATTATCGACCATGAATATGATTGTGTGGTGGTAGGCGCTGGCGGTGCAGGTTTAAGAGCAGCTTTCGGTTTGGCTGAAGCTGGATACAAGACTGCTTGTTTATCCAAGTTGTTTCCAACAAGGTCACATACTGTGGCTGCTCAGGGTGGAATTAATGCTGCGCTGGGAAATATGCATCCAGATGATTGGAAATCGCACATGTACGACACTGTCAAGGGTTCTGACTGGCTCGGAGACCAAGATGCAATCCATTACATGACAAGAGAAGCACCTAAGTCTGTCATTGAACTAGAACATTACGGTATGCCCTTTTCGAGGACTGAAGATGGAAGGATTTACCAGAGAGCATTTGGGGGACAATCCAAAGATTTTGGTAAAGGTGGACAGGCCTATAGGACTTGTGCGGTGGCAGATAGAACAGGTCACGCAATGCTTCATACATTGTATGGACAAGCGCTGAAAAATAATACACACTTCTTTATTGAATACTTTGCAATGGATTTGTTGACCCATAATGGCGAGGTTGTGGGTGTCATTGCCTATAATCAGGAGGACGGTACAATTCACAGATTCAGAGCACATAAGACCGTCATCGCGACAGGCGGATACGGTAGAGCTTACTTCTCTTGCACTTCTGCTCACACTTGTACAGGTGACGGTAATGCTATGGTTTCTCGCGCTGGATTTCCACTAGAGGATTTAGAATTTGTTCAATTTCATCCGTCAGGAATTTATGGGTCTGGCTGCCTAATCACTGAAGGTGCCCGTGGTGAGGGTGGATTTTTATTGAATTCTGAAGGAGAAAGGTTTATGGAACGCTATGCTCCTACTGCCAAGGACTTGGCAAGCAGGGATGTTGTTTCCAGAGCAATCACCATGGAAATCAGGGCTGGCAGAGGTGTCGGGAAAAACAAGGATCATATCCTTTTACAATTAAGCCATCTACCACCTGAGGTACTAAAGGAAAGGCTACCGGGAATATCTGAAACAGCTGCTGTCTTTGCGGGTGTCGATGTCACCCAGGAGCCAATTCCTGTCTTGCCAACTGTCCATTATAATATGGGAGGCATTCCCACAAAATGGACTGGTGAAGCATTGACCATTGACGAGGAAACTGGAGAGGATAAGGTCATCCCAGGATTGATGGCGTGTGGTGAAGCTGCTTGCGTATCGGTTCATGGAGCGAACAGATTAGGCGCTAACTCACTACTGGATTTAGTCGTTTTCGGTCGCGCCGTTGCAAATACCATTGCTGACACATTACAGCCTGGCTTGCCTCATAAGCCATTGGCTTCAAACATCGGGCACGAGTCAATTGCTAATTTGGATAAAGTAAGAAATGCTCGCGGCTCACTGAAAACCTCTCAAATCAGGTTGAACATGCAAAGGACAATGCAAAAAGATGTTTCTGTTTTCAGGACGCAAGACACTCTAGATGAAGGTGTTAGAAATATTACTGAAGTGGACAAGACATTTGAGGATGTGCACGTTTCTGATAAGTCAATGATCTGGAATTCTGATCTCGTAGAAACTCTGGAATTGCAAAATTTACTTACTTGTGCCACACAAACGGCTGTTTCTGCTTCCAAAAGAAAGGAGTCTCGTGGTGCTCATGCGAGAGAGGACTATGCAAAAAGAGATGATGTGAATTGGAGAAAGCACACATTATCATGGCAAAAGGGGACATCAACACCTGTAAAAATCAAGTACAGGAATGTAATCGCACATACTTTAGATGAGAATGAATGCGCCCCAGTCCCTCCAGCTGTCAGATCCTATTAA","protein_sequence":"MLSLKKGITKSYILQRTFTSSSVVRQIGEVKSESKPPAKYHIIDHEYDCVVVGAGGAGLRAAFGLAEAGYKTACLSKLFPTRSHTVAAQGGINAALGNMHPDDWKSHMYDTVKGSDWLGDQDAIHYMTREAPKSVIELEHYGMPFSRTEDGRIYQRAFGGQSKDFGKGGQAYRTCAVADRTGHAMLHTLYGQALKNNTHFFIEYFAMDLLTHNGEVVGVIAYNQEDGTIHRFRAHKTVIATGGYGRAYFSCTSAHTCTGDGNAMVSRAGFPLEDLEFVQFHPSGIYGSGCLITEGARGEGGFLLNSEGERFMERYAPTAKDLASRDVVSRAITMEIRAGRGVGKNKDHILLQLSHLPPEVLKERLPGISETAAVFAGVDVTQEPIPVLPTVHYNMGGIPTKWTGEALTIDEETGEDKVIPGLMACGEAACVSVHGANRLGANSLLDLVVFGRAVANTIADTLQPGLPHKPLASNIGHESIANLDKVRNARGSLKTSQIRLNMQRTMQKDVSVFRTQDTLDEGVRNITEVDKTFEDVHVSDKSMIWNSDLVETLELQNLLTCATQTAVSASKRKESRGAHAREDYAKRDDVNWRKHTLSWQKGTSTPVKIKYRNVIAHTLDENECAPVPPAVRSY"},{"created_at":"2011-05-26T18:06:41.000Z","updated_at":"2011-05-27T15:01:03.000Z","name":"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial","uniprot_id":"P21801","uniprot_name":"DHSB_YEAST","enzyme":true,"transporter":false,"gene_name":"SDH2","num_residues":266,"molecular_weight":"30230.90039","theoretical_pi":"8.97","general_function":"Involved in 2 iron, 2 sulfur cluster binding","specific_function":"Subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4","reactions":[{"id":2505,"direction":"\u003e","locations":" Matrix side; Peripheral membrane protein;Mitochondrion inner membrane","altext":"Succinate + ubiquinone = fumarate + ubiquinol.","export":false,"pw_reaction_id":null,"source":null},{"id":3707,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003287","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"AY558189","genbank_protein_id":"45270268","gene_card_id":"SDH2","chromosome_location":"chromosome 12","locus":"YLL041C","synonyms":["Iron-sulfur subunit of complex II","Ip"],"enzyme_classes":["1.3.5.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"}],"pfams":[{"name":"Fer2","identifier":"PF00111"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Oxidative phosphorylation","kegg_map_id":"00190"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGTTGAACGTGCTATTGAGAAGGAAGGCCTTTTGTTTGGTGACGAAGAAGGGTATGGCTACTGCCACAACAGCTGCAGCTACGCATACCCCCAGATTGAAAACTTTTAAAGTTTACAGATGGAATCCAGACGAGCCAAGTGCTAAACCTCATTTACAGTCATATCAAGTGGATCTGAATGACTGTGGGCCCATGGTACTTGATGCGCTGTTAAAGATCAAAGACGAACAGGATTCTACCCTAACTTTTAGAAGATCATGTAGAGAAGGTATCTGCGGTTCATGTGCCATGAACATTGGCGGTAGAAACACGCTAGCTTGTATATGTAAGATCGACCAGAACGAATCCAAACAACTCAAGATCTATCCATTACCCCACATGTTTATTGTCAAAGATTTGGTACCTGATTTAACTAACTTCTACCAACAATACAAATCTATCCAACCTTACTTACAGAGATCATCGTTTCCAAAGGATGGAACGGAAGTGCTACAAAGTATTGAAGATCGTAAGAAACTGGATGGTCTTTACGAATGTATTCTGTGTGCATGCTGCTCTACTTCATGTCCATCGTACTGGTGGAACCAAGAACAGTATTTGGGCCCTGCCGTGCTAATGCAAGCCTACCGTTGGCTAATTGACTCTAGAGACCAAGCTACAAAGACAAGAAAGGCCATGCTAAACAACTCCATGTCATTGTACAGATGTCACACCATCATGAACTGTACTAGAACTTGTCCAAAGGGCTTGAATCCTGGTTTGGCTATTGCTGAAATTAAGAAATCTTTGGCATTTGCCTAG","protein_sequence":"MLNVLLRRKAFCLVTKKGMATATTAAATHTPRLKTFKVYRWNPDEPSAKPHLQSYQVDLNDCGPMVLDALLKIKDEQDSTLTFRRSCREGICGSCAMNIGGRNTLACICKIDQNESKQLKIYPLPHMFIVKDLVPDLTNFYQQYKSIQPYLQRSSFPKDGTEVLQSIEDRKKLDGLYECILCACCSTSCPSYWWNQEQYLGPAVLMQAYRWLIDSRDQATKTRKAMLNNSMSLYRCHTIMNCTRTCPKGLNPGLAIAEIKKSLAFA"},{"created_at":"2011-05-26T18:22:03.000Z","updated_at":"2011-05-27T15:01:04.000Z","name":"Mitochondrial 2-methylisocitrate lyase","uniprot_id":"Q12031","uniprot_name":"ACEB_YEAST","enzyme":true,"transporter":false,"gene_name":"ICL2","num_residues":575,"molecular_weight":"64975.39844","theoretical_pi":"7.63","general_function":"Involved in isocitrate lyase activity","specific_function":"Catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl- CoA. Does not act on isocitrate","reactions":[{"id":1735,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2527,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"Z48951","genbank_protein_id":"763005","gene_card_id":"ICL2","chromosome_location":"chromosome 16","locus":"YPR006C","synonyms":["Methylisocitrate lyase"],"enzyme_classes":["4.1.3.30"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" isocitrate lyase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"}],"pfams":[{"name":"ICL","identifier":"PF00463"}],"pathways":[{"name":"Propanoate metabolism","kegg_map_id":"00640"}],"gene_sequence":"ATGATTACAATGATTAACAACAAAACTTTCAATAGAAAAACTACGGGAACACTGAAGAAGCTGGTTTTGTCATCAGACAAGTCACTGCGAAGATCTTTCAACGGGGCAAGCAGTACTAAAGACTTCGTGTTCTCGGAATCAAGTAAAGTAGAAGAATGGTGGGAATCAGCCAGATTTAAGAATATCAGTCGTCCATACTCAGCTACGGATGTTGTAAAGCATCGGGGCAGCCTTCCTGCTAATACTTCAATTTATCCTTCATCTTATCAAGCTCGAAAGCTGTTCAACTTACTAGAAGAGAATTTCAAGAATGGTACTCCACTTCACACGTTGGGAGTTATCGATCCTGTACAAATGAGTCAGTTGGCCCGTTGCAGAAATATCAAAGTTGCTTACATATCTGGTTGGGCTTGTTCTTCCACATTAGTTGGATCTACAAATGAAGTATCGCCGGATTTTGGCGATTATCCATACGATACTGTGCCGAATCAAGTGGAGAGAATATTCAAGGCGCAGCAATTGCACGATCGAAAGGCTTTCTTGGAGGCCTCCATCAAAGGTTCTACTCCTGTTGATTATTTAAAACCAATTATCGCGGACGCAGACATGGGTCACGGTGGCCCAACGACTGTAATGAAAGTTGCTAAGTTGTTTGCGGAGAAAGGGGCTGCTGGTATTCATCTTGAAGATCAGATGGTGGGAGGCAAAAGGTGTGGCCATCTAAGTGGGGCTGTTTTGGTGCCCACAGCAACACATCTTATGAGATTGATTTCCACCAGGTTTCAATGGGATATCATGGGGACAGAAAATTTGGTTATTGCAAGAACAGATTCCTGTAATGGTAAGCTGTTGAGTTCAAGCAGTGATCCGAGAGACCACGAATTCATTAGGGGTATAATAAGAGATAACGTGGTGCCTTGGAGCGAAAAATTGATTGAGATGGAGGACAAAAAAATTCCCAACTCCGCCATTGCTGACATGGAAAAAGAATGGTACCATGAAAATGAGCTGTTTACATTTGAAGAGGCCTTAGAAAAGCAGTTTACGGCAAGCGAGTTTGAAAGCTATAAAGAAAAGAAGGAAGACCTTATGGTAAACAAGCTGGGTAGAGCATACCTAAGCTTAAGAGAAATGAAACTTTTAGCTCAAGAAGTGACACCACTAAAGAAAATTATATTTGACTGGGATGCTCCGAGGACCAAAGAGGGATATTACATGTTTAACGGTTGTATTGAAGCAGCTATTAGAAGATCTTTGGTGTTTGCCCCATATTCTGATATGATTTGGCTGGAAACGAAAACTCCTGACCTGGAGCAGGCACGCTCATTTTCAAGAAAAATTCATAAACAACTTCCAGCTACCAAGCTAGTATATAACTTATCTCCTAGTTTCAATTGGAGCGCTCACGGCTTTGATGATAAGGCATTAAAATCCTTCGTATGGGACTTGGCAAAAGAAGGCTTCACGTTGCAACTGGTTTCCCTTGCCGGTCTGCATTCAGATGGAGTATCATTCTGGGAATTAGCCAATAGCTTCCAAAGTGACGGAATGAAAGCATACGTCGAAAAAGTGCAAAAACGGGAAAAGGAGACTAATTGTGATATCATGACACACCAGCTATGGTCTGGTGCAGAATATGTTGATTCCTTAATGAAAGTTGTCCAAAACGGTGCTTCATCCCAAACTTTAAGTACATCTGGTGAGAGCTTTACCGAAACGCAATTTTGA","protein_sequence":"MITMINNKTFNRKTTGTLKKLVLSSDKSLRRSFNGASSTKDFVFSESSKVEEWWESARFKNISRPYSATDVVKHRGSLPANTSIYPSSYQARKLFNLLEENFKNGTPLHTLGVIDPVQMSQLARCRNIKVAYISGWACSSTLVGSTNEVSPDFGDYPYDTVPNQVERIFKAQQLHDRKAFLEASIKGSTPVDYLKPIIADADMGHGGPTTVMKVAKLFAEKGAAGIHLEDQMVGGKRCGHLSGAVLVPTATHLMRLISTRFQWDIMGTENLVIARTDSCNGKLLSSSSDPRDHEFIRGIIRDNVVPWSEKLIEMEDKKIPNSAIADMEKEWYHENELFTFEEALEKQFTASEFESYKEKKEDLMVNKLGRAYLSLREMKLLAQEVTPLKKIIFDWDAPRTKEGYYMFNGCIEAAIRRSLVFAPYSDMIWLETKTPDLEQARSFSRKIHKQLPATKLVYNLSPSFNWSAHGFDDKALKSFVWDLAKEGFTLQLVSLAGLHSDGVSFWELANSFQSDGMKAYVEKVQKREKETNCDIMTHQLWSGAEYVDSLMKVVQNGASSQTLSTSGESFTETQF"},{"created_at":"2011-05-27T02:03:15.000Z","updated_at":"2011-05-27T15:01:16.000Z","name":"Alpha-ketoglutarate-dependent sulfonate dioxygenase","uniprot_id":"Q12358","uniprot_name":"JLP1_YEAST","enzyme":true,"transporter":false,"gene_name":"JLP1","num_residues":412,"molecular_weight":"46982.30078","theoretical_pi":"6.65","general_function":"Involved in oxidoreductase activity","specific_function":"Acts as a alpha-ketoglutarate-dependent dioxygenase active on sulfonates. Although taurine is a poor substrate, a variety of other sulfonates are utilized, with the best natural substrates being isethionate and taurocholate","reactions":[{"id":1994,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":14420,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006933","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY692737","genbank_protein_id":"51012925","gene_card_id":"JLP1","chromosome_location":"chromosome 12","locus":"YLL057C","synonyms":[],"enzyme_classes":["1.14.11.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"TauD","identifier":"PF02668"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGTCTCCTGCAGCAGCTCAAACAGCAATCCCTCTTCCATCTACCGATTTACCAGTCAAAATCATTACAAATGGGTTGAAAAACCTGAATTATACCTCCAAGCAAGGTTACGGGAATTTTGATACCCATTTTTATGATGGCCAAGATGAGGTCTCTCCATCTGGTTTATTGAAAATCCGTAAATCTTATAGAGAGAAATCGAAGTATCCAGATTATTTGCCTACATGGGATCCTACTGAAAAGTATGGCCCGCTGGAATTTCACGAATACCATGATCCTGCTTTGAGAGCTGACGGTAACTTTTCAAACCTTTTTGCAAAAGAAAACGTTGGTCAACTAAAGGTGAAGAAGATCACCCCGAAATTAGGTCTCGAGATCAATGGGATCCAGCTAACTGATCTTTCTGATGCTGCAAAAGATGAACTCGCTTTGCTTGTCGCCCAAAAGGGAGTAGTTGTCTTTAGAAATCAGAATTTTGCTGACGAGGGACCCGATTATGTGACTGAATACGGAAGACATTTTGGCAAGTTGCACATTCATCAAACTAGTGGCCACCCTCAAAACAATCCTGAGCTGCATATCACTTTCCGAAGACCTGATGCGGAAGAATTTGCAAGAGTTTTTGATGACTCGACATCATCTGGTGGCTGGCACACAGACGTCTCTTACGAGTTACAGCCACCTTCTTATACTTTCTTTAGTGTTGTTGAAGGTCCTGATGGTGGTGGAGATACGTTATTTGCGGATACGATCGAGGCTTTCGACAGGTTGTCGAAGCCTTTGCAAGATTTCTTGAGCACGCTTCATGTCATCCATAGCTCAAAGGAACAGGCAGAGAATTCACAGCGCCAGGGCGGCATAAAAAGAAGAGCACCTGTCACGCATATTCATCCACTGGTCAGAGTTCATCCTGTCTTGAAAAAGAAATGCTTGTATGTCAATCGTGCATTTTCTAGGAAAATAGTCGAATTGAAAAGACAAGAATCTGAATCACTTTTGAATTTCTTGTACAATCTAGTGGAGAGCAGCCATGATTTACAGTTAAGAGCCAAATGGGAACCTCATTCCGTCGTCATTTGGGATAACCGCAGAGTTCAACATTCAGCAGTGATTGATTGGGAAGAACCAATTCACAGACATGCGTTCAGGATTACTCCACAAGCGGAAAGGCCCGTGGAAGATCTAAAGTTTTTGAATGATGAAAATTATTATCCTTCTTCATTAACTTTGGATATTTGA","protein_sequence":"MSPAAAQTAIPLPSTDLPVKIITNGLKNLNYTSKQGYGNFDTHFYDGQDEVSPSGLLKIRKSYREKSKYPDYLPTWDPTEKYGPLEFHEYHDPALRADGNFSNLFAKENVGQLKVKKITPKLGLEINGIQLTDLSDAAKDELALLVAQKGVVVFRNQNFADEGPDYVTEYGRHFGKLHIHQTSGHPQNNPELHITFRRPDAEEFARVFDDSTSSGGWHTDVSYELQPPSYTFFSVVEGPDGGGDTLFADTIEAFDRLSKPLQDFLSTLHVIHSSKEQAENSQRQGGIKRRAPVTHIHPLVRVHPVLKKKCLYVNRAFSRKIVELKRQESESLLNFLYNLVESSHDLQLRAKWEPHSVVIWDNRRVQHSAVIDWEEPIHRHAFRITPQAERPVEDLKFLNDENYYPSSLTLDI"},{"created_at":"2011-05-27T02:29:27.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial","uniprot_id":"P07275","uniprot_name":"PUT2_YEAST","enzyme":true,"transporter":false,"gene_name":"PUT2","num_residues":575,"molecular_weight":"64434.60156","theoretical_pi":"7.0","general_function":"Involved in oxidoreductase activity","specific_function":"(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H","reactions":[{"id":1437,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1685,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1688,"direction":"\u003c\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1698,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1699,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2676,"direction":"\u003e","locations":"Mitochondrion inner membrane","altext":"(S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null},{"id":3772,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006294","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane","genbank_gene_id":"M10029","genbank_protein_id":"172303","gene_card_id":"PUT2","chromosome_location":"chromosome 8","locus":"YHR037W","synonyms":["P5C dehydrogenase"],"enzyme_classes":["1.5.1.12"],"go_classes":[{"category":"Component","description":" cytoplasmic part"},{"category":"Component","description":" mitochondrial part"},{"category":"Component","description":" mitochondrial matrix"},{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Function","description":" 1-pyrroline-5-carboxylate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"},{"category":"Process","description":" proline metabolic process"},{"category":"Process","description":" proline biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Aldedh","identifier":"PF00171"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"4-aminobutanoate degradation","kegg_map_id":null}],"gene_sequence":"ATGCTATCAGCAAGGTGCCTCAAATCTATATACTTCAAGAGATCTTTCTCACAACTGGGACACATCAAGCCCCCCAAGCACATAAGAAATGAACCTGTTAAGCCATTTAGAAACATAGACTTAAAAGACTGGGACTTACTGAGGGCTTCCTTGATGAAATTCAAAAGTTCTTCTTTAGAAGTGCCACTGGTCATCAATGGGGAAAGGATATATGACAATAATGAAAGAGCGCTTTTCCCGCAGACTAACCCTGCGAACCATCAACAAGTACTGGCAAACGTCACACAAGCCACGGAAAAAGATGTCATGAATGCTGTAAAAGCCGCCAAGGATGCCAAAAAGGATTGGTACAATCTACCGTTTTATGACAGATCTGCAATTTTTTTGAAAGCCGCTGACTTAATTTCCACCAAGTATCGTTATGACATGTTAGCTGCTACAATGCTGGGCCAGGGAAAAAATGTGTATCAGGCAGAAATCGACTGTATCACGGAATTATCTGACTTTTTTAGATACTATGTCAAGTATGCATCAGACTTGTATGCTCAACAACCCGTGAGTCGAGCGGATGGTACTTGGAATAAAGCTGAATACAGACCTTTAGAGGGATTTGTGTATGCTGTTTCACCATTCAACTTTACTGCTATTGCTGCAAACTTGATTGGGGCTCCAGCTTTGATGGGTAATACAGTTGTCTGGAAACCTTCACAAACCGCTGCCCTTTCAAATTACTTATTGATGACTGTTTTGGAAGAAGCGGGATTGCCAAAGGGTGTCATAAATTTCATTCTAGGTGATCCAGTTCAAGTTACTGACCAGGTATTAGCTGATAAAGATTTTGGTGCCTTGCATTTTACCGGTTCTACAAATGTCTTTAAGAGTTTGTATGGCAAAATACAAAGTGGCGTTGTTGAAGGGAAGTACAGAGATTACCCCCGTATTATTGGTGAGACAGGTGGTAAAAATTTCCATCTAGTTCACCCAAGTGCAAATATATCACATGCAGTACTCTCTACTATTAGAGGCACTTTCGAGTTCCAAGGCCAAAAGTGCTCTGCCGCTTCTAGGTTATATCTTCCAGAGTCAAAAAGTGAAGAATTCTTATCCGATATGTTTGGCATATTGCAGTCACAGAATGTTGTCCCAATGAACACATCCGCAAGTCCAATTTCTGGTGGGAATTTGCGGGGATTTATGGGTCCTGTCATCCATGAACAAAGTTTCGACAAATTAGTTAAAGTAATTGAAGATGCAAAGAAAGACCCCGAGTTGGAAATTCTTTACGGTGGACAATACGATAAAAGCCAAGGTTGGTTTGTCGGACCCACAGTCATAAAAGCCAAGAGACCAGATCATCCATATATGTCAACAGAATTTTTTGGCCCTATATTAACTGTTTACGAGTATCCAGATACGGAATTTAATGAAATCTGTGATATTATCGATAATACGAGTCAATACGCCTTAACTGGTGCTATTTTTGCCAAAGATCGTAAAGCAATTGAATACGCAGATGAGAAGTTGAAGTTTAGCGCAGGAAATTTCTACATAAATGATAAGTGTACTGGTGCCGTTGTTTCTCAGCAATGGTTTGGTGGCGCAAGAATGAGTGGTACCGACGGTAAGGCTGGTGGTCCAAACATTTTAAGCAGATTTGTCAGTATTAGAAACACAAAGGAGAGCTTCTACGAGTTGACTGATTTCAAATATCCATCGAATTATGAATAA","protein_sequence":"MLSARCLKSIYFKRSFSQLGHIKPPKHIRNEPVKPFRNIDLKDWDLLRASLMKFKSSSLEVPLVINGERIYDNNERALFPQTNPANHQQVLANVTQATEKDVMNAVKAAKDAKKDWYNLPFYDRSAIFLKAADLISTKYRYDMLAATMLGQGKNVYQAEIDCITELSDFFRYYVKYASDLYAQQPVESADGTWNKAEYRPLEGFVYAVSPFNFTAIAANLIGAPALMGNTVVWKPSQTAALSNYLLMTVLEEAGLPKGVINFIPGDPVQVTDQVLADKDFGALHFTGSTNVFKSLYGKIQSGVVEGKYRDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQKCSAASRLYLPESKSEEFLSDMFGILQSQNVVPMNTSASPISGGNLRGFMGPVIHEQSFDKLVKVIEDAKKDPELEILYGGQYDKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYEYPDTEFNEICDIIDNTSQYALTGAIFAKDRKAIEYADEKLKFSAGNFYINDKCTGAVVSQQWFGGARMSGTDDKAGGPNILSRFVSIRNTKENFYELTDFKYPSNYE"},{"created_at":"2011-05-27T05:25:59.000Z","updated_at":"2011-05-27T15:01:24.000Z","name":"Succinate-semialdehyde dehydrogenase [NADP+]","uniprot_id":"P38067","uniprot_name":"UGA2_YEAST","enzyme":true,"transporter":false,"gene_name":"UGA2","num_residues":497,"molecular_weight":"54188.80078","theoretical_pi":"6.62","general_function":"Involved in oxidoreductase activity","specific_function":"Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H","reactions":[{"id":1988,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2771,"direction":"\u003e","locations":null,"altext":"Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null},{"id":3751,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006276","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z35875","genbank_protein_id":"4388565","gene_card_id":"UGA2","chromosome_location":"chromosome 2","locus":"YBR006W","synonyms":["SSDH"],"enzyme_classes":["1.2.1.16"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Aldedh","identifier":"PF00171"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Tyrosine metabolism","kegg_map_id":"00350"},{"name":"Butanoate metabolism","kegg_map_id":"00650"},{"name":"Glutamate Metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTTTGAGTAAGTATTCTAAACCAACTCTAAACGACCCTAATTTATTCAGAGAATCTGGTTATATTGACGGAAAATGGGTTAAGGGCACTGACGAAGTTTTTGAGGTGGTAGACCCTGCTTCCGGCGAAATCATAGCAAGAGTTCCCGAACAACCAGTCTCCGTGGTTGAGGAAGCGATTGATGTTGCCTATGAAACTTTCAAGACGTACAAGAATACAACACCAAGAGAGAGGGCAAAGTGGCTCAGAAACATGTATAACTTAATGCTTGAAAATTTGGATGATCTGGCAACCATCATTACTTTAGAAAATGGTAAAGCTCTAGGGGAAGCTAAAGGAGAAATCAAATACGCGGCTTCGTATTTTGAGTGGTACGCCGAGGAAGCACCCCGTTTATATGGTGCTACTATTCAACCCTTGAACCCTCACAACAGAGTATTCACAATTAGGCAACCTGTTGGTGTATGCGGTATAATTTGTCCATGGAATTTTCCGAGCGCCATGATCACGAGAAAGGCCGCCGCTGCTTTAGCTGTGGGCTGCACAGTAGTCATCAAGCCAGACTCTCAAACGCCGCTATCTGCTTTAGCAATGGCATATTTGGCTGAAAAGGCAGGCTTTCCCAAGGGTTCGTTTAATGTTATTCTTTCACATGCCAACACACCAAAGCTTGGTAAAACATTATGTGAATCACCAAAAGTCAAGAAAGTTACTTTTACTGGTTCTACAAACGTCGGTAAAATCTTGATGAAACAATCTTCTTCTACTTTGAAGAAACTGTCTTTTGAGCTGGGTGGTAACGCCCCTTTCATAGTCTTTGAGGATGCCGATTTGGATCAAGCCTTGGAACAAGCCATGGCTTGTAAATTTAGGGGTTTGGGTCAAACATGTGTGTGCGCAAATAGACTTTACGTTCACTCATCCATAATTGATAAATTTGCGAAATTACTCGCGGAGAGGGTCAAAAAATTCGTAATTGGCCATGGTTTGGACCCAAAAACTACACATGGTTGTGTCATTAACTCCAGCGCTATTGAAAAAGTTGAAAGACATAAACAGGATGCCATTGATAAGGGAGCAAAAGTTGTGCTTGAAGGTGGACGTTTAACTGAGTTAGGTCCTAACTTTTATGCTCCAGTAATTTTGTCACACGTTCCCTCAACAGCTATTGTTTCCAAGGAGGAGACTTTTGGTCCATTATGTCCAATCTTTTCTTTTGATACTATGGAAGAAGTTGTCGGATATGCTAATGATACTGAGTTTGGTTTAGCAGCATATGTCTTTTCTAAAAATGTCAACACTTTATACACTGTGTCTGAAGCTTTGGAAACTGGTATGGTTTCATGTAATACAGGTGTTTTTTCGGATTGTTCTATACCATTTGGTGGTGTTAAAGAGTCAGGATTTGGAAGAGAAGGTTCGCTATATGGTATTGAAGATTACACTGTTTTGAAGACCATCACAATTGGGAATTTGCCAAACAGCATTTAA","protein_sequence":"MTLSKYSKPTLNDPNLFRESGYIDGKWVKGTDEVFEVVDPASGEIIARVPEQPVSVVEEAIDVAYETFKTYKNTTPRERAKWLRNMYNLMLENLDDLATIITLENGKALGEAKGEIKYAASYFEWYAEEAPRLYGATIQPLNPHNRVFTIRQPVGVCGIICPWNFPSAMITRKAAAALAVGCTVVIKPDSQTPLSALAMAYLAEKAGFPKGSFNVILSHANTPKLGKTLCESPKVKKVTFTGSTNVGKILMKQSSSTLKKLSFELGGNAPFIVFEDADLDQALEQAMACKFRGLGQTCVCANRLYVHSSIIDKFAKLLAERVKKFVIGHGLDPKTTHGCVINSSAIEKVERHKQDAIDKGAKVVLEGGRLTELGPNFYAPVILSHVPSTAIVSKEETFGPLCPIFSFDTMEEVVGYANDTEFGLAAYVFSKNVNTLYTVSEALETGMVSCNTGVFSDCSIPFGGVKESGFGREGSLYGIEDYTVLKTITIGNLPNSI"},{"created_at":"2011-05-27T07:14:15.000Z","updated_at":"2011-07-22T17:54:36.000Z","name":"Dihydroorotate dehydrogenase","uniprot_id":"P28272","uniprot_name":"PYRD_YEAST","enzyme":true,"transporter":false,"gene_name":"URA1","num_residues":314,"molecular_weight":"34800.60156","theoretical_pi":"5.85","general_function":"Involved in catalytic activity","specific_function":"In the de novo pyrimidine biosynthesic pathway, catalyzes the stereospecific oxidation of (S)-dihydroorotate to orotate and the reduction of fumarate to succinate. Does not use oxaloacetate and NAD or NADP as electron acceptors","reactions":[{"id":1453,"direction":"\u003e","locations":"mitochondrion;mitochondrial membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1454,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1554,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2803,"direction":"\u003e","locations":"Cytoplasm","altext":"(S)-dihydroorotate + O(2) = orotate + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2804,"direction":"\u003e","locations":"Cytoplasm","altext":"(S)-dihydroorotate + a quinone = orotate + a quinol","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AJ585637","genbank_protein_id":"45719878","gene_card_id":"URA1","chromosome_location":"chromosome 11","locus":"YKL216W","synonyms":["DHOD","DHODase","DHOdehase","Dihydroorotate oxidase"],"enzyme_classes":["1.3.3.1","1.3.5.2"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" dihydroorotate oxidase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor"},{"category":"Function","description":" dihydroorotate dehydrogenase activity"},{"category":"Process","description":" cellular aromatic compound metabolic process"},{"category":"Process","description":" nucleobase metabolic process"},{"category":"Process","description":" pyrimidine base metabolic process"},{"category":"Process","description":" pyrimidine base biosynthetic process"},{"category":"Process","description":" 'de novo' pyrimidine base biosynthetic process"},{"category":"Process","description":" pyrimidine nucleotide metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" pyrimidine nucleotide biosynthetic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" pyrimidine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" pyrimidine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" UMP biosynthetic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"DHO_dh","identifier":"PF01180"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGACAGCCAGTTTAACTACCAAGTTCTTGAACAATACCTATGAAAACCCATTTATGAATGCATCCGGTGTTCATTGCATGACTACACAAGAATTAGATGAATTAGCAAACTCTAAAGCTGGCGCATTCATTACAAAGAGTGCTACAACCTTAGAAAGAGAAGGTAACCCTGAACCACGTTACATTTCTGTCCCTCTAGGCAGTATCAACTCCATGGGTTTACCAAACGAAGGTATCGACTACTATTTGTCCTATGTATTAAACCGTCAAAAGAATTATCCTGATGCACCTGCTATTTTCTTCTCAGTTGCTGGTATGAGCATTGATGAAAATTTAAATTTGTTGAGGAAAATCCAAGATAGCGAATTCAACGGTATTACCGAGTTAAACTTGTCTTGTCCTAATGTGCCTGGGAAACCACAAGTTGCTTATGACTTTGACTTGACAAAGGAAACCTTGGAAAAGGTTTTTGCCTTTTTCAAAAAACCTCTTGGTGTCAAGTTGCCTCCTTATTTTGATTTTGCCCATTTTGATATCATGGCAAAAATATTGAACGAGTTCCCATTAGCTTATGTCAACTCTATCAATAGTATAGGAAATGGTCTTTTCATTGATGTGGAGAAGGAGAGTGTAGTAGTGAAGCCAAAGAATGGTTTCGGGGGTATTGGAGGTGAATATGTTAAGCCAACCGCGCTCGCCAATGTTCGTGCATTTTACACTCGTTTGAGACCTGAAATCAAAGTTATCGGTACAGGTGGAATTAAGTCCGGTAAGGATGCATTTGAACATCTTCTATGTGGTGCCTCTATGCTACAGATTGGTACAGAATTACAAAAAGAGGGCGTCAAGATTTTTGAACGTATCGAAAAAGAATTAAAAGACATAATGGAAGCTAAGGGTTATACATCCATAGATCAGTTCCGTGGGAAGTTGAACAGCATTTAA","protein_sequence":"MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLNSI"},{"created_at":"2011-05-27T09:03:42.000Z","updated_at":"2011-05-27T15:01:30.000Z","name":"Succinate/fumarate mitochondrial transporter","uniprot_id":"P33303","uniprot_name":"SFC1_YEAST","enzyme":false,"transporter":true,"gene_name":"SFC1","num_residues":322,"molecular_weight":"35340.10156","theoretical_pi":"10.31","general_function":"Involved in binding","specific_function":"Transports cytoplasmic succinate, derived from isocitrate by the action of isocitrate lyase in the cytosol, into the mitochondrial matrix in exchange for fumarate","reactions":[],"signal_regions":"None","transmembrane_regions":"11-31;68-88;114-134;177-193;219-235;278-295","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein","genbank_gene_id":"AY692924","genbank_protein_id":"51013299","gene_card_id":"SFC1","chromosome_location":"chromosome 10","locus":"YJR095W","synonyms":["Regulator of acetyl-CoA synthase activity"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" organelle inner membrane"},{"category":"Component","description":" mitochondrial inner membrane"},{"category":"Function","description":" binding"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[],"gene_sequence":"ATGTCTCAAAAAAAGAAGGCTTCCCATCCAGCCATCAATCTCATGGCTGGCGGCACAGCAGGTTTATTTGAAGCATTGTGTTGTCATCCTTTAGATACAATTAAGGTGAGAATGCAAATATACAGACGGGTAGCTGGTATTGAACATGTTAAACCCCCAGGATTTATTAAAACTGGGCGTACCATTTATCAAAAAGAAGGTTTCTTGGCTCTGTATAAAGGTCTAGGTGCTGTGGTCATCGGTATTATACCTAAGATGGCAATCCGTTTCTCGTCTTATGAATTCTATAGAACCTTATTGGTTAACAAGGAATCAGGAATTGTGTCTACCGGTAATACTTTTGTTGCTGGTGTTGGGGCTGGTATCACCGAAGCTGTTCTTGTCGTGAACCCGATGGAAGTTGTAAAGATTAGGTTACAAGCTCAGCATTTAACTCCGAGTGAGCCAAATGCTGGTCCTAAATATAACAACGCCATTCATGCAGCCTACACTATTGTCAAAGAAGAAGGTGTTTCTGCCTTATATAGAGGCGTTTCCTTAACTGCGGCAAGGCAAGCAACTAATCAGGGTGCTAACTTCACAGTTTATTCTAAACTGAAGGAGTTTTTGCAGAATTACCATCAGATGGATGTCCTACCTTCATGGGAAACTTCTTGCATAGGTTTGATTTCGGGTGCTATTGGGCCGTTTTCCAACGCTCCATTGGATACTATAAAGACAAGGCTGCAAAAGGATAAGTCCATCTCATTGGAAAAACAGTCCGGTATGAAGAAAATCATAACCATTGGTGCTCAACTACTGAAAGAAGAAGGTTTTAGAGCTTTGTACAAGGGTATTACCCCAAGAGTGATGAGGGTGGCTCCAGGTCAGGCTGTCACCTTTACCGTTTATGAATATGTAAGGGAGCATTTAGAAAATTTGGGTATATTCAAGAAGAATGACACACCAAAGCCAAAGCCATTAAAGTAG","protein_sequence":"MSQKKKASHPAINLMAGGTAGLFEALCCHPLDTIKVRMQIYRRVAGIEHVKPPGFIKTGRTIYQKEGFLALYKGLGAVVIGIIPKMAIRFSSYEFYRTLLVNKESGIVSTGNTFVAGVGAGITEAVLVVNPMEVVKIRLQAQHLTPSEPNAGPKYNNAIHAAYTIVKEEGVSALYRGVSLTAARQATNQGANFTVYSKLKEFLQNYHQMDVLPSWETSCIGLISGAIGPFSNAPLDTIKTRLQKDKSISLEKQSGMKKIITIGAQLLKEEGFRALYKGITPRVMRVAPGQAVTFTVYEYVREHLENLGIFKKNDTPKPKPLK"},{"created_at":"2011-05-27T09:25:13.000Z","updated_at":"2011-05-27T15:01:30.000Z","name":"Mitochondrial dicarboxylate transporter","uniprot_id":"Q06143","uniprot_name":"DIC1_YEAST","enzyme":false,"transporter":true,"gene_name":"DIC1","num_residues":298,"molecular_weight":"32991.30078","theoretical_pi":"10.1","general_function":"Involved in antiporter activity","specific_function":"Mitochondrial dicarboxylic transporter catalyzing the exchange of dicarboxylic acids like malate and succinate for inorganic phosphate. Required for growth on ethanol and acetate","reactions":[],"signal_regions":"None","transmembrane_regions":"17-37;58-76;105-126;170-189;211-231;265-283","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein","genbank_gene_id":"U19028","genbank_protein_id":"609395","gene_card_id":"DIC1","chromosome_location":"chromosome 12","locus":"YLR348C","synonyms":["DTP","Dicarboxylate carrier 1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" binding"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[{"name":"Aspartate metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCAACCAACGCAAAAGAGTCTGCCGGTAAGAATATCAAGTATCCATGGTGGTACGGAGGTGCAGCGGGTATCTTTGCTACCATGGTGACACATCCTCTTGACTTGGCCAAAGTCAGACTGCAGGCGGCTCCTATGCCCAAGCCCACACTCTTCAGGATGTTGGAGAGTATCTTGGCGAATGAAGGTGTGGTGGGGTTATATTCCGGCCTGAGCGCTGCTGTGTTGAGGCAATGTACATACACGACGGTGAGATTCGGTGCATACGACTTGTTGAAAGAGAATGTGATCCCACGCGAGCAATTGACTAACATGGCGTATCTTTTACCTTGCTCCATGTTCAGTGGTGCCATTGGGGGGCTTGCAGGGAATTTTGCAGATGTTGTAAATATCAGAATGCAAAACGACTCTGCTTTGGAGGCAGCGAAGAGGAGAAACTACAAAAACGCTATCGATGGTGTGTACAAGATATATCGCTACGAGGGTGGACTGAAAACCTTGTTTACCGGTTGGAAGCCTAACATGGTTAGGGGCATACTGATGACGGCAAGTCAGGTCGTTACGTATGACGTGTTTAAGAACTACTTGGTCACAAAATTAGATTTCGACGCATCCAAGAACTATACACACTTGACAGCGTCCCTGTTGGCTGGCCTGGTGGCCACCACTGTGTGCTCTCCAGCAGACGTCATGAAGACACGTATCATGAACGGCAGCGGAGACCATCAACCGGCTTTGAAGATCCTTGCCGACGCTGTCCGCAAAGAGGGCCCATCTTTCATGTTCCGGGGGTGGTTGCCAAGTTTCACTAGACTGGGTCCATTCACAATGTTAATTTTCTTTGCAATTGAGCAATTGAAAAAACATAGGGTTGGCATGCCAAAGGAAGACAAGTAG","protein_sequence":"MSTNAKESAGKNIKYPWWYGGAAGIFATMVTHPLDLAKVRLQAAPMPKPTLFRMLESILANEGVVGLYSGLSAAVLRQCTYTTVRFGAYDLLKENVIPREQLTNMAYLLPCSMFSGAIGGLAGNFADVVNIRMQNDSALEAAKRRNYKNAIDGVYKIYRYEGGLKTLFTGWKPNMVRGILMTASQVVTYDVFKNYLVTKLDFDASKNYTHLTASLLAGLVATTVCSPADVMKTRIMNGSGDHQPALKILADAVRKEGPSFMFRGWLPSFTRLGPFTMLIFFAIEQLKKHRVGMPKEDK"}]}