{"ymdb_id":"YMDB16245","created_at":"2016-09-12T18:27:52.000Z","updated_at":"2016-10-17T22:34:43.000Z","name":"Acetylhomoserine","cas":null,"state":null,"melting_point":null,"description":null,"experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":null,"hmdb_id":null,"kegg_id":null,"pubchem_id":null,"cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"4-(acetyloxy)-2-aminobutanoic acid","traditional_iupac":"O-acetylhomoserine","logp":"-3.387033704166865","pka":null,"alogps_solubility":"8.39e+01 g/l","alogps_logp":"-2.87","alogps_logs":"-0.28","acceptor_count":"4","donor_count":"2","rotatable_bond_count":"5","polar_surface_area":"89.62","refractivity":"36.057900000000004","polarizability":"15.543185352052863","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"9.458194751674373","pka_strongest_acidic":"2.015703027729805","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":[],"pathways":[{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"growth_conditions":[],"references":[],"proteins":[{"created_at":"2011-05-24T21:17:06.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Homoserine O-acetyltransferase","uniprot_id":"P08465","uniprot_name":"MET2_YEAST","enzyme":true,"transporter":false,"gene_name":"MET2","num_residues":486,"molecular_weight":"53659.0","theoretical_pi":"5.35","general_function":"Involved in O-acetyltransferase activity","specific_function":"Acetyl-CoA + L-homoserine = CoA + O-acetyl-L- homoserine","reactions":[{"id":1642,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2377,"direction":"\u003e","locations":null,"altext":"Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.","export":false,"pw_reaction_id":null,"source":null},{"id":3774,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006296","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z71553","genbank_protein_id":"1302344","gene_card_id":"MET2","chromosome_location":"chromosome 14","locus":"YNL277W","synonyms":["Homoserine O-trans-acetylase"],"enzyme_classes":["2.3.1.31"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" homoserine O-acetyltransferase activity"},{"category":"Function","description":" O-acyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" O-acetyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Process","description":" sulfur amino acid metabolic process"},{"category":"Process","description":" sulfur amino acid biosynthetic process"},{"category":"Process","description":" methionine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Abhydrolase_1","identifier":"PF00561"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Sulfur metabolism","kegg_map_id":"00920"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGTCGCATACTTTAAAATCGAAAACGCTCCAAGAGCTGGACATTGAGGAGATTAAGGAAACTAACCCATTGCTCAAACTAGTTCAAGGGCAGAGGATTGTTCAAGTTCCGGAACTAGTGCTTGAGTCTGGCGTGGTCATAAATAATTTCCCTATTGCTTATAAGACGTGGGGTACACTGAATGAAGCTGGTGATAATGTTCTGGTAATTTGTCATGCCTTGACTGGGTCCGCAGATGTTGCTGACTGGTGGGGCCCTCTTCTGGGTAACGACTTAGCATTCGACCCATCAAGGTTTTTTATCATATGTTTAAACTCTATGGGCTCTCCATATGGGTCTTTTTCGCCATTAACGATAAATGAGGAGACGGGCGTTAGATATGGACCCGAATTCCCATTATGTACTGTGCGCGATGACGTTAGAGCTCACAGAATTGTTCTGGATTCTCTGGGAGTAAAGTCAATAGCCTGTGTTATTGGTGGCTCTATGGGGGGGATGCTGAGTTTGGAATGGGCTGCCATGTATGGTAAGGAATATGTGAAGAATATGGTTGCTCTGGCGACATCAGCAAGACATTCTGCCTGGTGCATATCGTGGTCTGAGGCTCAAAGACAATCGATTTACTCAGATCCCAACTACTTGGACGGGTACTATCCGGTAGAGGAGCAACCTGTGGCCGGACTATCGGCTGCACGTATGTCTGCATTGTTGACGTACAGGACAAGAAACAGTTTCGAGAACAAATTCTCCAGAAGATCTCCTTCAATAGCACAACAACAAAAAGCTCAAAGGGAGGAGACACGCAAACCATCTACTGTCAGCGAACACTCCCTACAAATCCACAATGATGGGTATAAAACAAAAGCCAGCACTGCCATCGCTGGCATTTCTGGGCAAAAAGGTCAAAGCGTGGTGTCCACCGCATCTTCTTCGGATTCATTGAATTCTTCAACATCGATGACTTCGGTAAGTTCTGTAACGGGTGAAGTGAAGGACATAAAGCCTGCGCAGACGTATTTTTCTGCACAAAGTTACTTGAGGTACCAGGGCACAAAGTTCATCAATAGGTTCGACGCCAATTGTTACATTGCCATCACACGTAAACTGGATACGCACGATTTGGCAAGAGACAGAGTAGATGACATCACTGAGGTCCTTTCTACCATCCAACAACCATCCCTGATCATCGGTATCCAATCTGATGGACTGTTCACATATTCAGAACAAGAATTTTTGGCTGAGCACATACCGAAGTCGCAATTAGAAAAAATTGAATCTCCCGAAGGCCACGATGCCTTCCTATTGGAGTTTAAGCTGATAAACAAACTGATAGTACAATTTTTAAAAACCAACTGCAAGGCCATTACCGATGCCGCTCCAAGAGCTTGGGGAGGTGACGTTGGTAACGATGAAACGAAGACGTCTGTCTTTGGTGAGGCCGAAGAAGTTACCAACTGGTAG","protein_sequence":"MSHTLKSKTLQELDIEEIKETNPLLKLVQGQRIVQVPELVLESGVVINNFPIAYKTWGTLNEAGDNVLVICHALTGSADVADWWGPLLGNDLAFDPSRFFIICLNSMGSPYGSFSPLTINEETGVRYGPEFPLCTVRDDVRAHRIVLDSLGVKSIACVIGGSMGGMLSLEWAAMYGKEYVKNMVALATSARHSAWCISWSEAQRQSIYSDPNYLDGYYPVEEQPVAGLSAARMSALLTYRTRNSFENKFSRRSPSIAQQQKAQREETRKPSTVSEHSLQIHNDGYKTKASTAIAGISGQKGQSVVSTASSSDSLNSSTSMTSVSSVTGEVKDIKPAQTYFSAQSYLRYQGTKFINRFDANCYIAITRKLDTHDLARDRVDDITEVLSTIQQPSLIIGIQSDGLFTYSEQEFLAEHIPKSQLEKIESPEGHDAFLLEFKLINKLIVQFLKTNCKAITDAAPRAWGGDVGNDETKTSVFGEAEEVTNW"},{"created_at":"2011-05-26T16:30:36.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Protein MET17","uniprot_id":"P06106","uniprot_name":"MET17_YEAST","enzyme":true,"transporter":false,"gene_name":"MET17","num_residues":444,"molecular_weight":"48671.39844","theoretical_pi":"6.41","general_function":"Involved in pyridoxal phosphate binding","specific_function":"Transforms O-acetylhomoserine into homocysteine and O- acetylserine into cysteine","reactions":[{"id":1797,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1798,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2422,"direction":"\u003e","locations":"Cytoplasm","altext":"O-acetyl-L-homoserine + methanethiol = L-methionine + acetate.","export":false,"pw_reaction_id":null,"source":null},{"id":2420,"direction":"\u003e","locations":"Cytoplasm","altext":"O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate.","export":false,"pw_reaction_id":null,"source":null},{"id":3775,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006297","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY723848","genbank_protein_id":"51830472","gene_card_id":"MET17","chromosome_location":"chromosome 12","locus":"YLR303W","synonyms":["O-acetylhomoserine sulfhydrylase","OAH sulfhydrylase","Homocysteine synthase","O-acetylserine sulfhydrylase","OAS sulfhydrylase"],"enzyme_classes":["2.5.1.49","2.5.1.47"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGCCATCTCATTTCGATACTGTTCAACTACACGCCGGCCAAGAGAACCCTGGTGACAATGCTCACAGATCCAGAGCTGTACCAATTTACGCCACCACTTCTTATGTTTTCGAAAACTCTAAGCATGGTTCGCAATTGTTTGGTCTAGAAGTTCCAGGTTACGTCTATTCCCGTTTCCAAAACCCAACCAGTAATGTTTTGGAAGAAAGAATTGCTGCTTTAGAAGGTGGTGCTGCTGCTTTGGCTGTTTCCTCCGGTCAAGCCGCTCAAACCCTTGCCATCCAAGGTTTGGCACACACTGGTGACAACATCGTTTCCACTTCTTACTTATACGGTGGTACTTATAACCAGTTCAAAATCTCGTTCAAAAGATTTGGTATCGAGGCTAGATTTGTTGAAGGTGACAATCCAGAAGAATTCGAAAAGGTCTTTGATGAAAGAACCAAGGCTGTTTATTTGGAAACCATTGGTAATCCAAAGTACAATGTTCCGGATTTTGAAAAAATTGTTGCAATTGCTCACAAACACGGTATTCCAGTTGTCGTTGACAACACATTTGGTGCCGGTGGTTACTTCTGTCAGCCAATTAAATACGGTGCTGATATTGTAACACATTCTGCTACCAAATGGATTGGTGGTCATGGTACTACTATCGGTGGTATTATTGTTGACTCTGGTAAGTTCCCATGGAAGGACTACCCAGAAAAGTTCCCTCAATTCTCTCAACCTGCCGAAGGATATCACGGTACTATCTACAATGAAGCCTACGGTAACTTGGCATACATCGTTCATGTTAGAACTGAACTATTAAGAGATTTGGGTCCATTGATGAACCCATTTGCCTCTTTCTTGCTACTACAAGGTGTTGAAACATTATCTTTGAGAGCTGAAAGACACGGTGAAAATGCATTGAAGTTAGCCAAATGGTTAGAACAATCCCCATACGTATCTTGGGTTTCATACCCTGGTTTAGCATCTCATTCTCATCATGAAAATGCTAAGAAGTATCTATCTAACGGTTTCGGTGGTGTCTTATCTTTCGGTGTAAAAGACTTACCAAATGCCGACAAGGAAACTGACCCATTCAAACTTTCTGGTGCTCAAGTTGTTGACAATTTAAAGCTTGCCTCTAACTTGGCCAATGTTGGTGATGCCAAGACCTTAGTCATTGCTCCATACTTCACTACCCACAAACAATTAAATGACAAAGAAAAGTTGGCATCTGGTGTTACCAAGGACTTAATTCGTGTCTCTGTTGGTATCGAATTTATTGATGACATTATTGCAGACTTCCAGCAATCTTTTGAAACGGTTTTCGCTGGCCAAAAACCATGA","protein_sequence":"MPSHFDTVQLHAGQENPGDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTFGAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDYPEKFPQFSQPAEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSNGFGGVLSFGVKDLPNADKETDPFKLSGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETVFAGQKP"},{"created_at":"2011-05-26T16:33:53.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"Cystathionine gamma-synthase","uniprot_id":"P47164","uniprot_name":"MET7_YEAST","enzyme":true,"transporter":false,"gene_name":"STR2","num_residues":639,"molecular_weight":"72349.89844","theoretical_pi":"5.88","general_function":"Involved in pyridoxal phosphate binding","specific_function":"O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate","reactions":[{"id":1421,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2421,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate.","export":false,"pw_reaction_id":null,"source":null},{"id":14296,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006793","source":"Smpdb"},{"id":14297,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006794","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"AY692979","genbank_protein_id":"51013409","gene_card_id":"STR2","chromosome_location":"chromosome 10","locus":"YJR130C","synonyms":["O-succinylhomoserine (thiol)-lyase","Sulfur transfer protein 2"],"enzyme_classes":["2.5.1.48"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGATATCTAGAACCATTGGTGAATCTATTCCGCCCAACACAAAACATGCTGTTTCCGTGTGTTTGCCCACATGGGAAGCTACAGTAGGCTATGAAGAGGGTGAAAGCAGTATAATTAACTCGCTTACTACCGGATATCCAAGATTTTTCATACACAAGTCAATAAAGAAATTATGTGAAATTTTATCCGCTAAGTACTCCATGGAAGATGAAGCTTGTCTTTGCTTCCCCTCTTACAAGGTTGCCAATAGGTGCAGAGAGTTTATCAAAGTGAAAACGGGTCTTTCTACCAAAGTACGCATCTTACAACTATGTACACCTAAACCTATGAACCAAGAGGAAAAGCTCTGGAGAAGGGAATGTAAAATCACGGTGGTGTTTGTAGACCAGGAAATATTCCCCGTGATGAAGCAGTATTGGCAACATTCTGGTGAGATTGTATCTAGCAGAATGGCGGAGTATATTTTACATGAATTACAAGTCAAGGATAATCTTAAGAAGATGGAAACAGTGGATAACGGTAAAAAATTTATGACCGAAGATGAAAACAGAGTGAACGAAGAATATATAGAAACGAGATTTGGGAGAAATTTAAATTTTCTTGCTGCTGATAAAGCCAAATATCTAATACGAAAGAGGATTGCCACAAAAGTTGTTGAAAAAATTGACTCTGAAGGTCTATCGGACCTATTCTCTTTTGAACACTATAACGAGAGCAACGGTCCATTCAATGTTGGCAGTGGAGAGGCTCTGGATGATGATCAGTTGAATTCGGACATACCTGCCGAAACAATTACTTCTATGGGAGAAAGTGGCTCAAACAGTACTTTTGAAAACACAGCTACCGATGACTTGAAGTTTCATGTCAACCCTAATACGGATGTTTACTTATTTCCAAGTGGAATGGCGTCCATTTTCACTGCCCACAGGCTGCTTTTAAACTTCGATGCCAAGCGCTTATCAAGGTCTTCTAGTAGACAAGATAAGTTGATTGGATATGGACCTCCGTTCAAGAAGACCGTCATGTTTGGATTCCCATATACAGATACTCTGAGCATTCTTCGGAAGTTCAATCACACACATTTCTTGGGACAGGGAGATTCAACGTCAATGAACGCTCTGAAAAATATTTTACATTCTGGTGAGCAAATACTGGCGGTATTTATAGAAGCTCCATCGAACCCACTGTTGAAAATGGGAGATTTACAAGAACTGAAAAGGCTATCAGACTTGTATTCATTTTACATAGTGGTCGATGAAACTGTGGGTGGCTTTGTCAATATAGATGTATTACCGTATGCCGATATTGTTTGTAGTTCGCTAACGAAAATCTTCAGCGGCGACTCGAACGTTATTGCAGGATCCTTAGTACTAAATCCTAGAGGAAAGATTTATGAGTTTGCTAGAAAATTTATGAAGACTGAAGACGGATATGAAGATTGCCTATGGTGCGAAGATGCGTTATGCCTGGAAAGAAATTCGAGAGACTTCGTGGAACGTACAATCAAGGTGAATACAAACACTGATATATTGTTAAAAAGGGTGTTATTGCCTCAGGTGGGAAAATTGTTCAAGAAAATATATTACCCCAGTTTAACATCAGAGGATACCAAGCGGAATTATGACAGCGTTATGTCTACAAAAGATGGTGGGTATGGAGGTTTATTTTCACTAACTTTTTTCAATATTGAAGAGGCAAAGAAGTTTTTCAATAATCTGGAATTGTGCAAAGGACCTTCTCTCGGTACGAATTTCACTTTGGCGTGTCCATATGCTATTATTGCCCACTACCAGGAATTAGACGAGGTAGCTCAATATGGTGTCGAAACAAATCTTGTAAGAGTGAGCGTCGGTTTGGAAAATAGCGACGTTTTATGCAATGTTTTTCAGCGTGCCATTGAGAAAGCTTTAGGGGAATAA","protein_sequence":"MISRTIGESIPPNTKHAVSVCLPTWEATVGYEEGESSIINSLTTGYPRFFIHKSIKKLCEILSAKYSMEDEACLCFPSYKVANRCREFIKVKTGLSTKVRILQLCTPKPMNQEEKLWRRECKITVVFVDQEIFPVMKQYWQHSGEIVSSRMAEYILHELQVKDNLKKMETVDNGKKFMTEDENRVNEEYIETRFGRNLNFLAADKAKYLIRKRIATKVVEKIDSEGLSDLFSFEHYNESNGPFNVGSGEALDDDQLNSDIPAETITSMGESGSNSTFENTATDDLKFHVNPNTDVYLFPSGMASIFTAHRLLLNFDAKRLSRSSSRQDKLIGYGPPFKKTVMFGFPYTDTLSILRKFNHTHFLGQGDSTSMNALKNILHSGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPYADIVCSSLTKIFSGDSNVIAGSLVLNPRGKIYEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTNTDILLKRVLLPQVGKLFKKIYYPSLTSEDTKRNYDSVMSTKDGGYGGLFSLTFFNIEEAKKFFNNLELCKGPSLGTNFTLACPYAIIAHYQELDEVAQYGVETNLVRVSVGLENSDVLCNVFQRAIEKALGE"}]}