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Adenylyl-sulfate kinase (Q02196)

Identification
NameAdenylyl-sulfate kinase
Synonyms
  • ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
  • Adenosine-5'-phosphosulfate kinase
  • APS kinase
Gene NameMET14
Enzyme Class
Biological Properties
General FunctionInvolved in ATP binding
Specific FunctionCatalyzes the synthesis of activated sulfate
Cellular LocationNot Available
SMPDB Pathways
Selenocompound metabolismPW002472 ThumbThumb?image type=greyscaleThumb?image type=simple
Sulfur metabolismPW002483 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Purine metabolismec00230 Map00230
Selenocompound metabolismec00450 Map00450
Sulfur metabolismec00920 Map00920
SMPDB Reactions
Adenosine phosphosulfate + Adenosine triphosphate → Phosphoadenosine phosphosulfate + ADP + hydron
KEGG Reactions
Adenosine phosphosulfate + Adenosine triphosphate → hydron + Phosphoadenosine phosphosulfate + ADP
Metabolites
YMDB IDNameView
YMDB00109Adenosine triphosphateShow
YMDB00120Phosphoadenosine phosphosulfateShow
YMDB00256Adenosine phosphosulfateShow
YMDB00862hydronShow
YMDB00914ADPShow
GO Classification
Component
Not Available
Function
transferase activity, transferring phosphorus-containing groups
binding
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
kinase activity
catalytic activity
transferase activity
Process
metabolic process
cellular metabolic process
sulfur metabolic process
sulfate assimilation
Gene Properties
Chromosome Locationchromosome 11
LocusYKL001C
Gene Sequence>609 bp ATGGCTACTAATATTACTTGGCATCCAAATCTTACTTACGACGAACGCAAGGCATTGAGA AAACAGGACGGTTGTACTATTTGGTTAACAGGTCTAAGTGCGTCAGGTAAAAGTACAATC GCCTGTGCGCTAGAACAGTTACTGCTCCAAAAAAACTTGTCTGCATATAGATTGGATGGT GACAACATTCGTTTTGGATTGAACAAGGATTTGGGTTTCTCAGAAAAGGACAGAAATGAA AACATTCGTAGAATTAGCGAAGTTTCTAAGCTATTTGCTGATTCATGTGCTATTTCAATC ACCTCATTTATCTCTCCATACAGAGTTGACAGAGATAGAGCTCGTGAACTACATAAGGAG GCTGGTTTGAAGTTCATTGAAATATTTGTTGATGTTCCATTAGAAGTCGCTGAGCAAAGG GACCCTAAGGGTTTATACAAGAAAGCTAGGGAGGGTGTAATCAAGGAGTTTACAGGTATT TCTGCCCCATATGAAGCGCCAAAAGCTCCAGAGCTACATTTGAGAACCGACCAGAAGACG GTTGAAGAATGTGCTACCATTATTTATGAGTACTTAATCAGTGAAAAAATCATCCGTAAG CATTTGTAA
Protein Properties
Pfam Domain Function
Protein Residues202
Protein Molecular Weight23060.09961
Protein Theoretical pI8.31
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Adenylyl-sulfate kinase MATNITWHPNLTYDERKALRKQDGCTIWLTGLSASGKSTIACALEQLLLQKNLSAYRLDG DNIRFGLNKDLGFSEKDRNENIRRISEVSKLFADSCAISITSFISPYRVDRDRARELHKE AGLKFIEIFVDVPLEVAEQRDPKGLYKKAREGVIKEFTGISAPYEAPKAPELHLRTDQKT VEECATIIYEYLISEKIIRKHL
References
External Links
ResourceLink
Saccharomyces Genome Database MET14
Uniprot IDQ02196
Uniprot NameKAPS_YEAST
GenBank Gene IDAY558261
Genebank Protein ID45270412
General Reference
  • Korch, C., Mountain, H. A., Bystrom, A. S. (1991). "Cloning, nucleotide sequence, and regulation of MET14, the gene encoding the APS kinase of Saccharomyces cerevisiae." Mol Gen Genet 229:96-108.1654509
  • Dusterhoft, A., Philippsen, P. (1992). "DNA sequencing and analysis of a 24.7 kb segment encompassing centromere CEN11 of Saccharomyces cerevisiae reveals nine previously unknown open reading frames." Yeast 8:749-759.1441752
  • Dujon, B., Alexandraki, D., Andre, B., Ansorge, W., Baladron, V., Ballesta, J. P., Banrevi, A., Bolle, P. A., Bolotin-Fukuhara, M., Bossier, P., et, a. l. .. (1994). "Complete DNA sequence of yeast chromosome XI." Nature 369:371-378.8196765
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106