S-Adenosyl-L-methionine (YMDB00438)

General function:

Involved in methyltransferase activity

Specific function:

Required for the methylation step in diphthamide biosynthesis

Gene Name:

DPH5

Uniprot ID:

P32469

Molecular weight:

33847.0

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Siroheme synthase involved in methionine biosynthesis

Gene Name:

MET1

Uniprot ID:

P36150

Molecular weight:

66124.70313

Reactions

General function:

Involved in acyltransferase activity

Specific function:

Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria

Gene Name:

CAT2

Uniprot ID:

P32796

Molecular weight:

77241.20313

Reactions

General function:

Involved in acyltransferase activity

Specific function:

Involved in the transfer of acetyl-CoA into mitochondria. May also be involved in the metabolism of acetate and of ethanol

Gene Name:

YAT1

Uniprot ID:

P80235

Molecular weight:

77764.79688

Reactions

General function:

Involved in acyltransferase activity

Specific function:

Involved in the shutteling of acetyl-CoA in the cell

Gene Name:

YAT2

Uniprot ID:

P40017

Molecular weight:

103333.0

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway

Gene Name:

COQ3

Uniprot ID:

P27680

Molecular weight:

36330.60156

Reactions

General function:

Involved in catalytic activity

Specific function:

Dethiobiotin + sulfur + 2 S-adenosyl-L- methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine

Gene Name:

BIO2

Uniprot ID:

P32451

Molecular weight:

41883.80078

Reactions

General function:

Involved in transaminase activity

Specific function:

Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor

Gene Name:

BIO3

Uniprot ID:

P50277

Molecular weight:

53708.39844

Reactions

General function:

Involved in methionine adenosyltransferase activity

Specific function:

Catalyzes the formation of S-adenosylmethionine from methionine and ATP

Gene Name:

SAM1

Uniprot ID:

P10659

Molecular weight:

41818.0

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (Probable)

Gene Name:

LIP5

Uniprot ID:

P32875

Molecular weight:

46246.80078

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation

Gene Name:

TMT1

Uniprot ID:

P32643

Molecular weight:

34768.0

Reactions

General function:

Involved in adenosylmethionine decarboxylase activity

Specific function:

S-adenosylmethionine decarboxylase is essential for normal growth, sporulation, maintenance of ds-RNA virus, biosynthesis of spermine and spermidine

Gene Name:

SPE2

Uniprot ID:

P21182

Molecular weight:

46232.0

Reactions

General function:

Involved in ubiquinone biosynthetic process

Specific function:

Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides

Gene Name:

COQ4

Uniprot ID:

O13525

Molecular weight:

38626.80078

General function:

Involved in [cytochrome c]-lysine N-methyltransferase a

Specific function:

Methyltransferase which mediates trimethylation of Lys- 77 of cytochrome c (CYC1)

Gene Name:

CTM1

Uniprot ID:

P38818

Molecular weight:

68283.60156

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNAs

Gene Name:

TRM10

Uniprot ID:

Q12400

Molecular weight:

34520.19922

Reactions

General function:

Involved in tRNA (adenine-N1-)-methyltransferase activity

Specific function:

Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. GCD14 is also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency

Gene Name:

GCD14

Uniprot ID:

P46959

Molecular weight:

43919.30078

Reactions

General function:

Involved in protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity

Specific function:

Mediates C-terminal methylation of the isoprenylated C- terminal cysteine in A-factor mating pheromone and Ras proteins

Gene Name:

STE14

Uniprot ID:

P32584

Molecular weight:

27887.40039

Reactions

General function:

Involved in protein methyltransferase activity

Specific function:

Methylates arginines in a variety of RNA-binding proteins. Methylates NOP3. Can catalyze both the mono- and asymmetric dimethylation

Gene Name:

HMT1

Uniprot ID:

P38074

Molecular weight:

39785.80078

Reactions

General function:

Involved in homocysteine S-methyltransferase activity

Specific function:

Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S- methylmethionine (SMM) to methionine

Gene Name:

MHT1

Uniprot ID:

Q12525

Molecular weight:

36714.5

Reactions

General function:

Involved in tRNA (guanine-N7-)-methyltransferase activity

Specific function:

Methyltransferase that catalyzes the formation of N(7)- methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity

Gene Name:

TRM8

Uniprot ID:

Q12009

Molecular weight:

33391.19922

Reactions

General function:

Involved in homocysteine S-methyltransferase activity

Specific function:

Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S- methylmethionine (SMM) to methionine

Gene Name:

SAM4

Uniprot ID:

Q08985

Molecular weight:

36668.19922

Reactions

General function:

Involved in nicotinamide N-methyltransferase activity

Specific function:

Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination

Gene Name:

NNT1

Uniprot ID:

Q05874

Molecular weight:

29632.30078

Reactions

General function:

Involved in phosphatidylethanolamine N-methyltransferas

Specific function:

S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine

Gene Name:

PEM1

Uniprot ID:

P05374

Molecular weight:

101203.0

Reactions

General function:

Involved in identical protein binding

Specific function:

Specifically methylates guanosine-37 in various tRNAs. Not dependent on the nature of the nucleoside 5' of the target nucleoside

Gene Name:

TRM5

Uniprot ID:

P38793

Molecular weight:

56514.0

Reactions

General function:

Involved in N-methyltransferase activity

Specific function:

S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid

Gene Name:

OPI3

Uniprot ID:

P05375

Molecular weight:

23150.09961

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol

Gene Name:

ERG6

Uniprot ID:

P25087

Molecular weight:

43430.5

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2- thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base

Gene Name:

SLM3

Uniprot ID:

Q12093

Molecular weight:

47048.80078

Reactions

General function:

Coenzyme transport and metabolism

Specific function:

Catalyzes the formation of S-adenosylmethionine from methionine and ATP

Gene Name:

SAM2

Uniprot ID:

P19358

Molecular weight:

42255.5

Reactions

General function:

Involved in RNA methyltransferase activity

Specific function:

Catalyzes the formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNA. May also have a role in tRNA stabilization or maturation

Gene Name:

TRM2

Uniprot ID:

P33753

Molecular weight:

72851.79688

Reactions

General function:

Involved in histone-lysine N-methyltransferase activity

Specific function:

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. Can bind to DNA (in vitro)

Gene Name:

DOT1

Uniprot ID:

Q04089

Molecular weight:

66200.70313

Reactions

General function:

Involved in histone-lysine N-methyltransferase activity

Specific function:

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression. The methyltransferase activity requires the recruitment to the RNA polymerase II, which is CTK1 dependent

Gene Name:

SET2

Uniprot ID:

P46995

Molecular weight:

84538.79688

Reactions

General function:

Involved in histone-lysine N-methyltransferase activity

Specific function:

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation

Gene Name:

SET1

Uniprot ID:

P38827

Molecular weight:

123911.0

Reactions