{"ymdb_id":"YMDB00438","created_at":"2011-05-29T18:17:16.000Z","updated_at":"2016-09-08T18:35:29.000Z","name":"S-Adenosyl-L-methionine","cas":"29908-03-0","state":"Solid","melting_point":null,"description":"S-Adenosyl-L-methionine (SAM) is a common co-substrate involved in methyl group transfers. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase [EC 2.5.1.6]. SAM is involved in transmethylation, transsulfuration, and aminopropylation metabolic pathways.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Cytoplasm, Endoplasmic Reticulum, Extracellular, Mitochondrion","synthesis_reference":null,"chebi_id":"15414","hmdb_id":"HMDB01185","kegg_id":"C00019","pubchem_id":"1079","cs_id":"21865164","foodb_id":null,"wikipedia_link":"S-Adenosyl_methionine","biocyc_id":"S-ADENOSYLMETHIONINE","iupac":"[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium","traditional_iupac":"SAMe","logp":"-5.318663457073791","pka":"12.444250657541687","alogps_solubility":"1.19e+00 g/l","alogps_logp":"-1.99","alogps_logs":"-2.56","acceptor_count":"10","donor_count":"5","rotatable_bond_count":"7","polar_surface_area":"182.63000000000002","refractivity":"96.2349","polarizability":"40.370553374384066","formal_charge":"1","physiological_charge":"1","pka_strongest_basic":"9.414366078981788","pka_strongest_acidic":"1.7027541004150226","bioavailability":"1","number_of_rings":"3","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt","[1-(adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium","2-S-adenosyl-L-methionine","5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate","acylcarnitine","Ademetionine","adenosylmethionine","AdoMet","Donamet","L-S-Adenosylmethionine","S-(5'-Adenosyl)-L-methionine","S-(5'-deoxyadenosin-5'-yl)-L-methionine","S-adenosyl methionine","S-adenosyl-L-methionine","S-Adenosyl-L-Methionine 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incorporation into Mitochondria PC(16:1(11Z)/16:1(11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(16:1(9Z)/16:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(18:0/18:0)","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(18:1(9Z)/18:1(9Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(18:2(9Z,11Z)/18:2(9Z,11Z))","kegg_map_id":null},{"name":"Lysolipid incorporation into Mitochondria PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Phosphatidylcholine biosynthesis","kegg_map_id":null},{"name":"Phosphatidylcholine biosynthesis PC(10:0/10:0)","kegg_map_id":null},{"name":"Phosphatidylcholine biosynthesis PC(10:0/12:0)","kegg_map_id":null},{"name":"Phosphatidylcholine biosynthesis PC(10:0/14:0)","kegg_map_id":null},{"name":"Phosphatidylcholine biosynthesis 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(2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":18625006,"citation":"Pirkov, I., Norbeck, J., Gustafsson, L., Albers, E. (2008). \"A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.\" FEBS J 275:4111-4120."},{"pubmed_id":194884,"citation":"Chiang, P. K., Cantoni, G. L. (1977). \"Activation of methionine for transmethylation. Purification of the S-adenosylmethionine synthetase of bakers' yeast and its separation into two forms.\" J Biol Chem 252:4506-4513."},{"pubmed_id":3087344,"citation":"Pegg, A. E. (1986). \"Recent advances in the biochemistry of polyamines in eukaryotes.\" Biochem J 234:249-262."},{"pubmed_id":1508200,"citation":"Mattheakis, L. C., Shen, W. H., Collier, R. J. (1992). \"DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae.\" Mol Cell Biol 12:4026-4037."},{"pubmed_id":14609944,"citation":"Marobbio, C. M., Agrimi, G., Lasorsa, F. M., Palmieri, F. (2003). \"Identification and functional reconstitution of yeast mitochondrial carrier for S-adenosylmethionine.\" EMBO J 22:5975-5982."},{"pubmed_id":12736687,"citation":"Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., Sinclair, D. A. (2003). \"Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.\" Nature 423:181-185."},{"pubmed_id":15147181,"citation":"Katz, J. E., Dumlao, D. S., Wasserman, J. I., Lansdown, M. G., Jung, M. E., Faull, K. F., Clarke, S. (2004). \"3-Isopropylmalate is the major endogenous substrate of the Saccharomyces cerevisiae trans-aconitate methyltransferase.\" Biochemistry 43:5976-5986."},{"pubmed_id":15792955,"citation":"Marbois, B., Gin, P., Faull, K. F., Poon, W. W., Lee, P. T., Strahan, J., Shepherd, J. N., Clarke, C. F. (2005). \"Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q.\" J Biol Chem 280:20231-20238."},{"pubmed_id":11013242,"citation":"Thomas, D., Becker, A., Surdin-Kerjan, Y. (2000). \"Reverse methionine biosynthesis from S-adenosylmethionine in eukaryotic cells.\" J Biol Chem 275:40718-40724."},{"pubmed_id":8647869,"citation":"Gary, J. D., Lin, W. J., Yang, M. C., Herschman, H. R., Clarke, S. (1996). \"The predominant protein-arginine methyltransferase from Saccharomyces cerevisiae.\" J Biol Chem 271:12585-12594."},{"pubmed_id":2445736,"citation":"Kodaki, T., Yamashita, S. (1987). \"Yeast phosphatidylethanolamine methylation pathway. Cloning and characterization of two distinct methyltransferase genes.\" J Biol Chem 262:15428-15435."},{"pubmed_id":9370337,"citation":"Yamashita, S., Nikawa, J. (1997). \"Phosphatidylserine synthase from yeast.\" Biochim Biophys Acta 1348:228-235."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T20:15:20.000Z","updated_at":"2011-07-22T17:54:38.000Z","name":"Diphthine synthase","uniprot_id":"P32469","uniprot_name":"DPH5_YEAST","enzyme":true,"transporter":false,"gene_name":"DPH5","num_residues":300,"molecular_weight":"33847.0","theoretical_pi":"4.56","general_function":"Involved in methyltransferase activity","specific_function":"Required for the methylation step in diphthamide biosynthesis","reactions":[{"id":1470,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2307,"direction":"\u003e","locations":"Cytoplasm","altext":"3 S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = 3 S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(trimethylammonio)propyl)-L-histidine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY557947","genbank_protein_id":"45269786","gene_card_id":"DPH5","chromosome_location":"chromosome 12","locus":"YLR172C","synonyms":["Diphthamide biosynthesis methyltransferase"],"enzyme_classes":["2.1.1.98"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" S-adenosylmethionine-dependent methyltransferase activity"},{"category":"Function","description":" diphthine synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" peptidyl-amino acid modification"},{"category":"Process","description":" peptidyl-histidine modification"},{"category":"Process","description":" peptidyl-diphthamide metabolic process"},{"category":"Process","description":" peptidyl-diphthamide biosynthetic process from peptidyl-histidine"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"}],"pfams":[{"name":"TP_methylase","identifier":"PF00590"}],"pathways":[],"gene_sequence":"ATGCTTTATTTGATCGGACTTGGTCTCTCGTACAAATCAGACATTACCGTTCGTGGTTTGGAAGCTATTAAGAAATGTTCTAGAGTTTATCTAGAACACTATACCAGTATCCTAATGGCTGCAAGCCAAGAAGAGTTAGAATCTTACTATGGTAAAGAGATCATCTTGGCTGATAGGGAATTAGTTGAGACTGGTTCTAAGCAGATCCTAAATAACGCCGATAAGGAAGACGTTGCTTTCTTGGTCGTGGGCGATCCATTTGGTGCCACCACACACACAGATTTAGTTCTCAGAGCTAAACGTGAGGCAATTCCCGTCGAAATTATTCATAATGCGTCCGTTATGAATGCAGTTGGGGCATGTGGCCTACAACTATACAATTTCGGTCAAACCGTTTCCATGGTTTTCTTTACCGATAATTGGAGACCAGACTCATGGTACGACAAGATCTGGGAAAATAGAAAAATTGGCCTTCATACTTTAGTGTTATTGGACATCAAAGTTAAGGAACAAAGCATTGAAAATATGGCCCGTGGCAGACTAATCTACGAACCACCAAGATACATGTCTATCGCTCAATGTTGTGAACAATTATTAGAAATTGAAGAGAAAAGAGGTACAAAGGCATACACTCCTGATACTCCAGCAGTCGCAATTAGTAGATTAGGCTCGAGCTCCCAAAGCTTTAAGTCTGGTACCATAAGTGAGTTAGCCAATTACGATTCAGGAGAGCCACTTCATTCGCTTGTCATCCTCGGCAGACAATGTCATGAATTGGAGCTGGAATACCTGCTAGAGTTTGCCGACGACAAAGAAAAGTTTGGGAAAGATGTGGCAAATGACCAAGAGTACTTCAAACTTGCGGCATGGGTCCCACCCACAGAAGACGACAGCGACGAGTAA","protein_sequence":"MLYLIGLGLSYKSDITVRGLEAIKKCSRVYLEHYTSILMAASQEELESYYGKEIILADRELVETGSKQILNNADKEDVAFLVVGDPFGATTHTDLVLRAKREAIPVEIIHNASVMNAVGACGLQLYNFGQTVSMVFFTDNWRPDSWYDKIWENRKIGLHTLVLLDIKVKEQSIENMARGRLIYEPPRYMSIAQCCEQLLEIEEKRGTKAYTPDTPAVAISRLGSSSQSFKSGTISELANYDSGEPLHSLVILGRQCHELELEYLLEFADDKEKFGKDVANDQEYFKPAAWVPPTEDDSDE"},{"created_at":"2011-05-24T20:23:06.000Z","updated_at":"2011-05-27T14:56:00.000Z","name":"Uroporphyrinogen-III C-methyltransferase","uniprot_id":"P36150","uniprot_name":"SUMT_YEAST","enzyme":true,"transporter":false,"gene_name":"MET1","num_residues":593,"molecular_weight":"66124.70313","theoretical_pi":"6.53","general_function":"Involved in methyltransferase activity","specific_function":"Siroheme synthase involved in methionine biosynthesis","reactions":[{"id":2041,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2312,"direction":"\u003e","locations":null,"altext":"S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.","export":false,"pw_reaction_id":null,"source":null},{"id":2313,"direction":"\u003e","locations":null,"altext":"S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z28294","genbank_protein_id":"486539","gene_card_id":"MET1","chromosome_location":"chromosome 11","locus":"YKR069W","synonyms":["Urogen III methylase","SUMT","Uroporphyrinogen III methylase","UROM"],"enzyme_classes":["2.1.1.107"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" uroporphyrin-III C-methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" C-methyltransferase activity"},{"category":"Process","description":" heme biosynthetic process"},{"category":"Process","description":" siroheme biosynthetic process"},{"category":"Process","description":" tetrapyrrole metabolic process"},{"category":"Process","description":" porphyrin metabolic process"},{"category":"Process","description":" porphyrin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"TP_methylase","identifier":"PF00590"}],"pathways":[{"name":"Porphyrin and chlorophyll metabolism","kegg_map_id":"00860"}],"gene_sequence":"ATGGTACGAGACTTAGTGACATTGCCTTCATCACTGCCCTTGATTACTGCTGGTTTTGCTACTGATCAGGTTCATTTGCTTATTGGTACAGGGTCCACGGACTCAGTAAGCGTTTGTAAGAATAGAATCCACTCCATTTTGAATGCTGGTGGTAATCCCATAGTAGTGAATCCCTCGTCACCAAGCCATACTAAACAATTACAATTGGAATTTGGTAAGTTTGCAAAGTTCGAAATAGTAGAAAGGGAGTTTAGGTTATCTGATTTAACTACTTTGGGGAGAGTTCTGGTATGCAAGGTAGTGGATAGAGTATTCGTAGATCTACCCATAACACAAAGTCGCCTATGCGAGGAGATCTTTTGGCAATGCCAAAAACTGAGAATTCCCATAAATACATTCCACAAACCAGAGTTTTCTACCTTCAATATGATTCCTACGTGGGTCGACCCAAAAGGAAGTGGTTTACAAATCTCAGTTACTACGAATGGGAATGGATACATCTTGGCAAACAGGATAAAAAGAGATATAATATCACACTTACCTCCAAACATATCTGAGGTGGTGATAAACATGGGGTATTTGAAAGACCGTATTATAAACGAAGACCATAAGGCCTTGTTAGAGGAAAAGTACTACCAGACTGACATGTCATTACCTGGATTTGGCTACGGCTTAGATGAGGACGGTTGGGAGAGCCATAAGTTTAATAAGCTAATTCGTGAATTTGAAATGACCAGTAGAGAACAGAGACTTAAGAGAACCAGATGGTTATCTCAGATAATGGAGTATTACCCGATGAACAAGCTGAGTGACATCAAGTTGGAAGATTTCGAGACTTCATCTTCTCCAAATAAAAAGACAAAGCAGGAAACTGTCACAGAGGGTGTAGTACCTCCTACCGATGAAAATATTGAAAACGGTACAAAACAACTACAATTATCGGAAGTGAAAAAAGAGGAGGGACCTAAAAAACTAGGGAAGATTTCTTTAGTCGGAAGTGGTCCAGGCTCGGTATCTATGCTAACGATAGGTGCATTACAAGAAATAAAGTCTGCAGATATAATACTGGCAGATAAACTGGTACCGCAAGCCATTTTAGATTTAATACCTCCAAAAACTGAAACCTTCATAGCCAAAAAATTTCCCGGTAATGCAGAACGAGCACAACAGGAATTACTAGCTAAAGGTTTAGAATCGTTGGATAATGGATTGAAAGTAGTCCGTTTGAAGCAAGGTGATCCGTATATTTTTGGCCGTGGTGGCGAGGAATTTAATTTCTTCAAAGATCACGGATATATTCCTGTGGTTTTACCGGGCATAAGCTCATCCCTAGCTTGTACTGTATTGGCTCAGATACCCGCTACTCAACGTGATATAGCAGACCAAGTGCTCATATGTACTGGGACTGGGAGAAAGGGCGCTCTGCCTATAATTCCTGAATTTGTTGAAAGCAGAACCACCGTCTTTCTAATGGCACTGCATCGCGCCAACGTTCTGATCACGGGATTATTGAAGCATGGCTGGGATGGTGATGTCCCCGCTGCAATTGTCGAGAGAGGATCGTGCCCTGACCAGCGTGTTACTAGAACTCTTCTTAAATGGGTACCAGAAGTCGTGGAGGAGATTGGTTCAAGGCCCCCCGGTGTCTTGGTTGTAGGCAAGGCTGTGAATGCATTGGTTGAAAAAGATCTGATAAATTTTGACGAATCAAGAAAATTTGTCATTGATGAAGGTTTTAGAGAATTTGAGGTTGATGTAGATAGTCTATTTAAGTTATACTAA","protein_sequence":"MVRDLVTLPSSLPLITAGFATDQVHLLIGTGSTDSVSVCKNRIHSILNAGGNPIVVNPSSPSHTKQLQLEFGKFAKFEIVEREFRLSDLTTLGRVLVCKVVDRVFVDLPITQSRLCEEIFWQCQKLRIPINTFHKPEFSTFNMIPTWVDPKGSGLQISVTTNGNGYILANRIKRDIISHLPPNISEVVINMGYLKDRIINEDHKALLEEKYYQTDMSLPGFGYGLDEDGWESHKFNKLIREFEMTSREQRLKRTRWLSQIMEYYPMNKLSDIKLEDFETSSSPNKKTKQETVTEGVVPPTDENIENGTKQLQLSEVKKEEGPKKLGKISLVGSGPGSVSMLTIGALQEIKSADIILADKLVPQAILDLIPPKTETFIAKKFPGNAERAQQELLAKGLESLDNGLKVVRLKQGDPYIFGRGGEEFNFFKDHGYIPVVLPGISSSLACTVLAQIPATQRDIADQVLICTGTGRKGALPIIPEFVESRTTVFLMALHRANVLITGLLKHGWDGDVPAAIVERGSCPDQRVTRTLLKWVPEVVEEIGSRPPGVLVVGKAVNALVEKDLINFDESRKFVIDEGFREFEVDVDSLFKLY"},{"created_at":"2011-05-24T21:27:14.000Z","updated_at":"2011-07-22T17:54:23.000Z","name":"Carnitine O-acetyltransferase, mitochondrial","uniprot_id":"P32796","uniprot_name":"CACP_YEAST","enzyme":true,"transporter":false,"gene_name":"CAT2","num_residues":670,"molecular_weight":"77241.20313","theoretical_pi":"8.4","general_function":"Involved in acyltransferase activity","specific_function":"Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria","reactions":[{"id":1367,"direction":"\u003c\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2388,"direction":"\u003e","locations":"Peroxisome. Mitochondrion inner membrane; Matrix side;Cytoplasm; Peripheral membrane protein; Intermembrane side;Mitochondrion inner membrane","altext":"Acetyl-CoA + carnitine = CoA + O-acetylcarnitine.","export":false,"pw_reaction_id":null,"source":null},{"id":14163,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006605","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Peroxisome. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"Z14021","genbank_protein_id":"3462","gene_card_id":"CAT2","chromosome_location":"chromosome 13","locus":"YML042W","synonyms":["Carnitine acetylase"],"enzyme_classes":["2.3.1.7"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Carn_acyltransf","identifier":"PF00755"}],"pathways":[{"name":"Fatty acid metabolism","kegg_map_id":"00071"}],"gene_sequence":"ATGAGGATCTGTCATTCGAGAACTCTCTCAAACTTAAAGGATCTTCCGATAACGTCAAGGAGAGCAATGCATTCGGCCATTGTCAATTACTCCACCCAAAAGGCCCAATTTCCCGTAGAGACAAATAATGGGGAACACTATTGGGCGGAAAAGCCGAACAAATTCTACCAGAACAAAAGGCCCAATTTTCAAGGCATTACCTTTGCTAAACAACAAGACTTACCATCATTACCCGTGCCCGAATTGAAGTCTACACTTGACAAGTATTTGCAAACCATCCGCCCATTTTGCAATGATGTAGAAACTTTTGAAAGACAGCAGCTGTTATGTAAGGACTTCTCGGAGCACATGGGGCCTATCTTACAAGACCGATTGAAAGAGTATGCCAACGATAAAAGAAACTGGATGGCCAAGTTTTGGGATGAACAATCCTATTTACAATACAACGATCCTATTGTTCCATACGTCTCTTATTTTTATTCTCATATGCCATTACCGAATCATTTATCGAAGATCGATAATGATCCTTTGATTAAGGCTACTGCGATTATCTCAACCGTGGTTAAATTCATCGAAGCTATTAAAGATGAATCTTTACCCGTAGAAATTATCAAAGGTATGCCATTTTGTATGAATAGTTTTTCATTGATGTTTAACACTTCGAGATTGCCTGGTAAGCCAGAGGATAACCAAGATACAAATATTTTTTATTCAGTTTATGAGAACAACTTTGTAACTATCGCTTATAAAGGGAAGTTTTACAAACTGATGACCCATGACGGGAATCACAAACCGCTTTCCGAAAACGAAATCTGGAGGCAACTGTACTCTGTGGTATTCCAAGGATCGCAGTCCGATCCCAAACTAGGTGGCATTGGTTCTCTCACCTCTTTACCTCGTGATCAATGGCGTGAAGTACATATGGAGCTTATGAAGGATCCTATTTCTCAGGATTCACTAGAAACAATCCATAAGTCTTCCTTTATGCTATGTTTGGATCTTGACCAATCCCCTGTCACTTTGGAAGAAAAGTCAAGAAATTGCTGGCACGGTGATGGTATTAACAGATTCTACGATAAGTCTTTACAGTTCCTAGTCACCGGTAATGGTTCATCAGGTTTCTTAGCTGAACACTCGAAGATGGATGGTACGCCAACATTGTTTTTAAATAACTACGTTTGTCAGCAGTTGAATAAACTAGATGTGGATGACTTCATGAGAAAAGTAATTACGCCATCATCTACGGTGGCAATGAAACCTATGGAACTGCCCTTCATTATCACACCGAAGATTCATAAAGCAATCGAATCTGCCCAACTACAATTTAAGGAAACAATTGGTGAGCATGACCTACGTGTTTGGCACTACAACAAATATGGAAAAACGTTTATAAAACGCCATGGCATGTCACCTGATGCATTTATTCAACAAGTTATCCAACTGGCGGTTTTCAAATATCTGAAACGACAACTACCAACTTACGAGGCTGCTTCCACGAGAAAATACTTCAAAGGCCGTACTGAAACTGGTAGATCTGTGTCCACCGCCTCCTTAGAATTTGTTTCTAAATGGCAAAATGGCGATGTTCCTATTGCAGAAAAGATTCAGGCTTTGAAACATTCTGCAAAAGAGCATTCGACGTACCTGAAAAATGCTGCAAATGGTAATGGTGTCGATCGTCATTTCTTCGGTCTAAAGAATATGCTAAAATCTAATGATGACCAAATTCCGCCCCTTTTCAAAGATCCCTTATTTAATTATTCTTCAACTTGGTTGATCTCCACATCTCAACTATCTTCGGAATATTTTGACGGTTATGGTTGGTCCCAAGTAAATGACAACGGGTTTGGACTGGCATACATGTTGAATAACGAGTGGCTGCATATCAATATTGTCAACAAACCAGCCAAGAGTGGAGCCAGTGTTAACAGATTACACTATTATTTATCTCAAGCTGCTGATGAAATTTTTGACGCCTTGGAAAATGAGAATAAACGAAAAGCAAAGTTATGA","protein_sequence":"MRICHSRTLSNLKDLPITSRRAMHSAIVNYSTQKAQFPVETNNGEHYWAEKPNKFYQNKRPNFQGITFAKQQDLPSLPVPELKSTLDKYLQTIRPFCNDVETFERQQLLCKDFSEHMGPILQDRLKEYANDKRNWMAKFWDEQSYLQYNDPIVPYVSYFYSHMPLPNHLSKIDNDPLIKATAIISTVVKFIEAIKDESLPVEIIKGMPFCMNSFSLMFNTSRLPGKPEDNQDTNIFYSVYENNFVTIAYKGKFYKLMTHDGNDKPLSENEIWRQLYSVVFQGSQSDPKLGGIGSLTSLPRDQWREVHLELMKDPISQDSLETIHKSSFMLCLDLDQSPVTLEEKSRNCWHGDGINRFYDKSLQFLVTGNGSSGFLAEHSKMDGTPTLFLNNYVCQQLNKLDVDDFMRKVITPSSTVAMKPMELPFIITPKIHKAIESAQLQFKETIGEHDLRVWHYNKYGKTFIKRHGMSPDAFIQQVIQLAVFKYLKRQLPTYEAASTRKYFKGRTETGRSVSTASLEFVSKWQNGDVPIAEKIQALKHSAKEHSTYLKNAANGNGVDRHFFGLKNMLKSNDDQIPPLFKDPLFNYSSTWLISTSQLSSEYFDGYGWSQVNDNGFGLAYMLNNEWLHINIVNKPAKSGASVNRLHYYLSQAADEIFDALENENKRKAKL"},{"created_at":"2011-05-24T21:29:14.000Z","updated_at":"2011-07-22T17:54:22.000Z","name":"Putative mitochondrial carnitine O-acetyltransferase","uniprot_id":"P80235","uniprot_name":"CACM_YEAST","enzyme":true,"transporter":false,"gene_name":"YAT1","num_residues":687,"molecular_weight":"77764.79688","theoretical_pi":"6.92","general_function":"Involved in acyltransferase activity","specific_function":"Involved in the transfer of acetyl-CoA into mitochondria. May also be involved in the metabolism of acetate and of ethanol","reactions":[{"id":1367,"direction":"\u003c\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2388,"direction":"\u003e","locations":"Peroxisome. Mitochondrion inner membrane; Matrix side;Cytoplasm; Peripheral membrane protein; Intermembrane side;Mitochondrion inner membrane","altext":"Acetyl-CoA + carnitine = CoA + O-acetylcarnitine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side","genbank_gene_id":"L28920","genbank_protein_id":"456138","gene_card_id":"YAT1","chromosome_location":"chromosome 1","locus":"YAR035W","synonyms":[],"enzyme_classes":["2.3.1.7"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Carn_acyltransf","identifier":"PF00755"}],"pathways":[],"gene_sequence":"ATGCCAAACTTAAAGAGACTACCCATCCCGCCACTGCAGGACACGCTCAACCGCTACCTGGCACGCGTGGAACCCCTGCAGGACGAGCGCCAAAACCGCCGTACGCGCCGCACTGTGCTCTCCGCAGAAAACCTGGACGCATTGAACACGCTGCACGAGCGGCTGCTAGAATACGACGCACGGCTCGCGGAAAGCAACCCAGAGTCCTCATACATCGAGCAGTTCTGGTATGACGCGTACTTGCTATATGATGCAACTGTCGTTCTCAACGTCAACCCGTACTTCCAACTGCAGGACGACCCAACCATCAAAGACACACCAGAGACGGCGGCACAGGGCCCCTATGGCGCACACACGGTGCAGGTTCGTCGTGCCGCACGACTCACCACCTCTATTCTCAAGTTCATCCGCCAGATTCGCCACGGCACACTCCGCACAGACACTGTGCGCGGCAAAACGCCGCTGTCGATGGACCAGTATGAGCGGCTATTCGGCTCCAGTAGAATCCCTCCGGGTCCCGGCGAGCCCTCTTGCCACTTGCAAACAGACGCCACGTCGCATCACGTGGTGGCGATGTATCGTGGCCAGTTCTACTGGTTCGACGTGCTGGACACACGCAACGAGCCCATCTTCGCCACCCCAGAACAACTGGAGTGGAACCTCTACTCGATCATCATGGACGCGGAATCCGCCGGAAGCGGATCCGCGCCCTTTGGCGTGTTCACCACAGAGTCGCGCCGGGTGTGGTCCAACATCAGGGACTATCTGTTCCATGCGGACGACTGCACCAACTGGCGCAATCTCAAGCTGATCGACTCCGCGCTGTTCGTGGTCTGTCTCGACGACGTGGCGTTTGCCGCCGATCAGCAGGACGAGCTCACGCGTTCGATGCTGTGCGGGACTTCTACCATCAATCTCGACCCGCACCAACACCAGCCGCCATTGAACGTGCAGACAGGCACCTGTCTCAACCGCTGGTACGACAAGTTACAACTGATCGTGACCAAGAACGGTAAGGCGGGCATCAACTTCGAACACACCGGTGTGGACGGCCACACTGTGCTGCGGCTCGCCACAGACATCTACACAGACTCGATCCTGAGCTTCGCACGCGGTGTCACCAAGAACGTCGTCGACATCTTTAGCGACGACGATGGAAAACCATCGTCGTCGTCGTTGGCCTCGGCGGCTCACTCCGCCAACTTGATCACCATCCCTCGTAAACTGGAATGGCGCACTGACAATTTCCTGCAATCGTCGCTGCACTTTGCCGAGACGCGCATCTCGGACTTGATCTCGCAATACGAGTTTGTTAATCTTGACTTCTCCAACTACGGCGCGTCCCATATCAAGACAGTGTTCAAGTGCTCGCCAGACGCCTTCGTGCAGCAGGTGTTCCAGGTCGCATACTTCGCGTTGTACGGTCGCTTCGAGACCGTGTACGAGCCTGCCATGACCAAGGCGTTCCAAAACGGCCGCACAGAGGCCATCCGCTCCGTCACGGGCCAATCGAAGCTCTTTGTCAAGTCACTACTGGACCAGGATGCCTCGGACGCCACCAAAATTCAGCTCTTGCACGACGCCTGTACGGCGCACTCGCAAATCACAAGGGAATGCTCCCAGGGGCTCGGCCAGGACCGTCACTTGTATGCGCTCTACTGCCTCTGGAACCAATGGTACAAGGACAAGTTGGAGCTCCCACCCATCTTCCGCGACAAGTCCTGGACTACCATGCAGAACAACGTCTTGAGCACCTCCAACTGCGGTAACCCCTGCCTCAAGAGCTTCGGGTTCGGGCCTGTCACCGCCAACGGCTTCGGCATCGGCTACATCATCAGAGACCACTCCGTCTCTGTGGTGGTGTCCTCAAGGCATCGCCAGACTGCTCGGTTTGCGTCGCTCATGGAAAAGTCGCTGCTGGAGATCGACCGCATCTTCAAACGGCAGCAAGCTCGCGCAGCAAAACCCGCTGCCAGGACCACTGCTAGCGCCAACACCAAATCAGAAGACATGAAATACCTGTTGTCCGGCTACGATTACTTCGACGTGAGCGTGTCCGGTTGA","protein_sequence":"MPNLKRLPIPPLQDTLNRYLARVEPLQDERQNRRTRRTVLSAENLDALNTLHERLLEYDARLAESNPESSYIEQFWYDAYLLYDATVVLNVNPYFQLQDDPTIKDTPETAAQGPYGAHTVQVRRAARLTTSILKFIRQIRHGTLRTDTVRGKTPLSMDQYERLFGSSRIPPGPGEPSCHLQTDATSHHVVAMYRGQFYWFDVLDTRNEPIFATPEQLEWNLYSIIMDAESAGSGSAPFGVFTTESRRVWSNIRDYLFHADDCTNWRNLKLIDSALFVVCLDDVAFAADQQDELTRSMLCGTSTINLDPHQHQPPLNVQTGTCLNRWYDKLQLIVTKNGKAGINFEHTGVDGHTVLRLATDIYTDSILSFARGVTKNVVDIFSDDDGKPSSSSLASAAHSANLITIPRKLEWRTDNFLQSSLHFAETRISDLISQYEFVNLDFSNYGASHIKTVFKCSPDAFVQQVFQVAYFALYGRFETVYEPAMTKAFQNGRTEAIRSVTGQSKLFVKSLLDQDASDATKIQLLHDACTAHSQITRECSQGLGQDRHLYALYCLWNQWYKDKLELPPIFRDKSWTTMQNNVLSTSNCGNPCLKSFGFGPVTANGFGIGYIIRDHSVSVVVSSRHRQTARFASLMEKSLLEIDRIFKRQQARAAKPAARTTASANTKSEDMKYLLSGYDYFDVSVSG"},{"created_at":"2011-05-26T16:13:31.000Z","updated_at":"2011-07-22T17:54:22.000Z","name":"Carnitine O-acetyltransferase YAT2","uniprot_id":"P40017","uniprot_name":"YAT2_YEAST","enzyme":true,"transporter":false,"gene_name":"YAT2","num_residues":923,"molecular_weight":"103333.0","theoretical_pi":"6.24","general_function":"Involved in acyltransferase activity","specific_function":"Involved in the shutteling of acetyl-CoA in the cell","reactions":[{"id":1367,"direction":"\u003c\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2388,"direction":"\u003e","locations":"Peroxisome. Mitochondrion inner membrane; Matrix side;Cytoplasm; Peripheral membrane protein; Intermembrane side;Mitochondrion inner membrane","altext":"Acetyl-CoA + carnitine = CoA + O-acetylcarnitine.","export":false,"pw_reaction_id":null,"source":null},{"id":14163,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006605","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U18778","genbank_protein_id":"603616","gene_card_id":"YAT2","chromosome_location":"chromosome 5","locus":"YER024W","synonyms":[],"enzyme_classes":["2.3.1.7"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring acyl groups other than amino-acyl groups"},{"category":"Function","description":" acyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Carn_acyltransf","identifier":"PF00755"}],"pathways":[{"name":"Fatty acid metabolism","kegg_map_id":"00071"}],"gene_sequence":"ATGTCAAGCGGCAGTACTATTGTTTCGTCTGACAAGTCGGGGCGAACATTTAAGCATGAGGAAGAACTACCCAAGTTACCATTACCTAAACTCTGTGACACTTTGCAGCGTCTGAAGGAGAGTTTAGAGCCATTGTATTATGCTGATGGTTACTATCAACATCCTTTAGATCCAGAACAAATTGAGAAGCTGTCATCCATAATAAGAGATTTTGAAGAGAATCCCGTAAGTGAGAAGCTGCAATCTAAACTACAGAGCTACCATGACACTAGGGATTGCTACCTTGATGAATTACACTTAGACATCAATAACCAGACCTCCACTAGGGAGATTCAGGACGATGTCCTACCCAGGAATCCCTTCTTGGTTCTCGCAGATGACGCTTTGCCAAACATCACTCAAGCTGATAGGTCAGCCGTCCTAGTGCACTCTGCGGCCAGGTTTATTTCTGCTTTGAAACAAGATTTGTTGCCACCAGATATCAATGCCACCAATGGCAAACCACTGTCAATGGCTCCATTTCTGAACTTGTTCGGTACTACTCGTAGTCCTGTTTTTCAGCGCGGTGAGGTTGAAAATTTTGATTTGAACAAACCTTACACAGCATCTGATTTAGAAGACCCTGATTATTCAAGCGATGAGGACGATAACGACGAACCCACCCAAAAAGACTTTGATGACCGTAAAAGAAAACACGAAGAAGACATATTCACTGGCAATGGTATAACTATAAAAAGACATCCGGATAGCAAACACATCTTGATCATCTCCAGGGGCCAATACTATACACTGGAAGTACTTGATTCGACGAATAAAATTATATACACTGCTGCAGAATTAACCACAATTTTCAACCATATAATAAAAGATTCTTCTGGCATTGAAAAATCAACTGCGTTAGGTAGTTTGACCTCTCACTCTTTTAGAAACTGGAAATATGCAAGGAAGAGACTACAGAAAAGGTATCCTAATGAATTACATCGCATAGACTCTGCTCTGTTCGTGTTAGTGCTGGACGAATCACAAGAAGAAACTACCAATGATGGCGATGATACCGCTGATATCAGTCAAATGTTTAACAGGACTATCACTGAGCGAGACAAGAAATGTACTTCCGCCAATTGTAAGAGAGTGTTTTACGGTACTTCTATAATAAATAGCAAAGGCCATCAAGTGGGTTCATGTGTTTCTCGTTGGTATGATAAATTACAGTTAGTTGTCACTGCAGATGCAAAAGCCACAGTGATTTGGGATTCCTTCACATGTGACGGGTCAGTCGTGCTTCGGTTTACTTCTGAAATTTATACAGAATCAGTCTTGAGATTAGCTAGAGACGTTAACGCCGGTGACCCACAGTTTTCACTCTGGCCTAACGTGACACAAATGGATCCTGAAACTAAAAAACTGATGACGGCGACCATAAGTGCCGACGGCGGAGGCCCTTCTGAAATTGACCCTAAGTTGGTTGTAAATAAAATCGATTGGTCTTTCAGTAACATCCTGAACACACATGTCCATTTGTCAGAAACCAAACTAGCTGATCTGATTTCCAAGTATGATATTGTTCGCGCTTCTATTCCATTGGGCAGAAGGTCAGCTCAAAGATTAGGAGTCAAGCCCGATTCGATGGTTCAAGTAGCTTTACAAATAGCTCACTATGCTTTGTATGGAAGAATGGTGTTTGGATTAGAACCAGTATCCACACGTGGTTTCAAAAACTCGAGATCATCTTTTATTAACATTCAAAGTCAAGCGCTGTTGGAACTATGTCAATTGTTTATTTCTAGCTCCATTGATGGGACAGATAAATTAGACAAATTTATCCAAACCTGCGAAACACATAATAACATGGTTAAACATGCAAAGTCTGGGGTAGGTTATGAAAAACACTTCAATGCATTGAAATATCTCTTCAAATTTCATGACCATTTTGGTATCCACTTAAGTGGTGATGAATCATCTGCTGCGAAAGATCTTTTCGAAAATCCACTTGTTTTACCTTTCTCACAGCCTGAGTTGATTGTTGCCAACTGTGGTAATGCTGCTACCACGACATTTGGTATAACTCCTGCTGTACCTCATGGCTTTGGAATAGGGTACATCATTAAAGATGATCAAGTAGATTTGACCGTGACATCGCAATTTCGACAGGGTGACAGGTTAATGTTTATGTTAAGTTGGGTGTTAGGCGAAATTCGTTCCTACTGGAGGATGTCACGCGGCACTTCTCATAATAAAACTGGCGTGAAGATCAGTCCAGTGGTCGATAAATTGTATGAAATGGACAATGCAGTCAATAATCCTCCGAAACGTAACGGCCATACAGTCAATGGCTCCCGCAAAACATCTTCTTCATCACAGGTAAATTTGAACAGGTATGGCGGGTTTTTCGATTTGGAAGGCCACATTGACAGTAGGAATATATCTAAAACACCATCGATGAAGAATTTGCAGAAAACCTTCAATGGCTTGACCATGAGCGCAGACAATGATCATTCAAGTTCCGCAGTTTCCGTTCCCACAGAAAAGGAAAAATTAAATACAGGCCATGAAATTTTACAGATCCAACCGCGGGAAGTGGCAAGTAATGGGTTGGAAGCAGATGATGAGACAGATATTGAAATAGTTGCTGGCAATGCTGATGGCACATCCTCTTCGGCATCTTCAGCTACATCTCTAAATTCCAAGAAACGTAACGTCATCAACTCAAGATTCGATATTGATTTTGACCGCAGTCGTGTGGGTAGAAAGGTGGCGACCTTAGATCAATAA","protein_sequence":"MSSGSTIVSSDKSGRTFKHEEELPKLPLPKLCDTLQRLKESLEPLYYADGYYQHPLDPEQIEKLSSIIRDFEENPVSEKLQSKLQSYHDTRDCYLDELHLDINNQTSTREIQDDVLPRNPFLVLADDALPNITQADRSAVLVHSAARFISALKQDLLPPDINATNGKPLSMAPFLNLFGTTRSPVFQRGEVENFDLNKPYTASDLEDPDYSSDEDDNDEPTQKDFDDRKRKHEEDIFTGNGITIKRHPDSKHILIISRGQYYTLEVLDSTNKIIYTAAELTTIFNHIIKDSSGIEKSTALGSLTSHSFRNWKYARKRLQKRYPNELHRIDSALFVLVLDESQEETTNDGDDTADISQMFNRTITERDKKCTSANCKRVFYGTSIINSKGHQVGSCVSRWYDKLQLVVTADAKATVIWDSFTCDGSVVLRFTSEIYTESVLRLARDVNAGDPQFSLWPNVTQMDPETKKLMTATISADGGGPSEIDPKLVVNKIDWSFSNILNTHVHLSETKLADLISKYDIVRASIPLGRRSAQRLGVKPDSMVQVALQIAHYALYGRMVFGLEPVSTRGFKNSRSSFINIQSQALLELCQLFISSSIDGTDKLDKFIQTCETHNNMVKHAKSGVGYEKHFNALKYLFKFHDHFGIHLSGDESSAAKDLFENPLVLPFSQPELIVANCGNAATTTFGITPAVPHGFGIGYIIKDDQVDLTVTSQFRQGDRLMFMLSWVLGEIRSYWRMSRGTSHNKTGVKISPVVDKLYEMDNAVNNPPKRNGHTVNGSRKTSSSSQVNLNRYGGFFDLEGHIDSRNISKTPSMKNLQKTFNGLTMSADNDHSSSAVSVPTEKEKLNTGHEILQIQPREVASNGLEADDETDIEIVAGNADGTSSSASSATSLNSKKRNVINSRFDIDFDRSRVGRKVATLDQ"},{"created_at":"2011-05-26T16:35:40.000Z","updated_at":"2011-05-29T05:06:18.000Z","name":"Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial","uniprot_id":"P27680","uniprot_name":"COQ3_YEAST","enzyme":true,"transporter":false,"gene_name":"COQ3","num_residues":312,"molecular_weight":"36330.60156","theoretical_pi":"6.98","general_function":"Involved in methyltransferase activity","specific_function":"Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway","reactions":[{"id":2429,"direction":"\u003e","locations":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","altext":"S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate.","export":false,"pw_reaction_id":null,"source":null},{"id":2430,"direction":"\u003e","locations":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","altext":"S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.","export":false,"pw_reaction_id":null,"source":null},{"id":2431,"direction":"\u003e","locations":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","altext":"S-adenosyl-L-methionine + 2-hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol = S-adenosyl-L-homocysteine + ubiquinol.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"M73270","genbank_protein_id":"171392","gene_card_id":"COQ3","chromosome_location":"chromosome 15","locus":"YOL096C","synonyms":["3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase","DHHB methyltransferase","DHHB-MT","DHHB-MTase","Dihydroxyhexaprenylbenzoate methyltransferase"],"enzyme_classes":["2.1.1.114","2.1.1.64"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" C-methyltransferase activity"},{"category":"Function","description":" quinone cofactor methyltransferase activity"},{"category":"Function","description":" 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" oxidoreduction coenzyme metabolic process"},{"category":"Process","description":" ubiquinone metabolic process"},{"category":"Process","description":" ubiquinone biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"}],"pfams":[{"name":"Methyltransf_11","identifier":"PF08241"}],"pathways":[{"name":"Ubiquinone and other terpenoid-quinone biosynthesis","kegg_map_id":"00130"}],"gene_sequence":"ATGGGATTCATAATGTTGTTAAGATCTAGATTTTTGAAGGTTATTCATGTGAGGAAACAATTGAGCGCCTGTTCAAGATTTGCAATTCAAACACAAACGAGATGTAAGAGCACAGATGCTTCTGAAGATGAAGTGAAGCATTTCCAGGAGCTAGCCCCTACTTGGTGGGATACAGACGGATCACAAAGAATTCTACACAAAATGAATCTAACTAGGTTAGATTTTGTGCAGAGGACTGTGAGGAACCAGGTTAAAATTCAGAATCCTGAAATATTTGTCCCTGGATTTAATTACAAGGAGTTTCTACCAGAATACGTCTGCGACAATATTCAGCGGGAAATGCAGGAAAGCATAGAGACTAATCTAGATAAGAGGCCAGAAGTGAGCGTCTTGGATGTTGGATGCGGTGGTGGCATTTTGAGTGAATCGCTCGCGAGACTAAAATGGGTGAAGAATGTTCAAGGGATCGATCTGACTCGCGATTGTATCATGGTAGCAAAAGAGCATGCCAAGAAAGACCCCATGCTGGAGGGAAAGATAAATTATGAGTGCAAGGCTCTGGAGGATGTTACTGGACAATTTGATATTATCACCTGTATGGAAATGCTAGAGCACGTGGATATGCCTAGTGAAATTTTAAGGCATTGTTGGTCGAGGTTAAATCCCGAAAAAGGTATACTCTTTTTAAGTACTATAAACAGAGATCTCATCTCATGGTTTACTACAATTTTTATGGGTGAAAACGTCTTGAAGATCGTCCCAAAGGGTACTCATCATTTGAGCAAATACATAAACTCAAAGGAAATCCTTGCCTGGTTCAATGACAACTACAGTGGCCAATTTCGCTTGTTGGATCTCAAGGGGACCATGTACCTCCCATATCAAGGGTGGGTTGAGCACGATTGTTCCGATGTCGGTAATTATTTTATGGCTATTCAGAGACTGAATTGA","protein_sequence":"MLLRSRFLKVIHVRKQLSACSRFAIQTQTRCKSTDASEDEVKHFQELAPTWWDTDGSQRILHKMNLTRLDFVQRTVRNQVKIQNPEIFVPGFNYKEFLPEYVCDNIQREMQESIETNLDKRPEVSVLDVGCGGGILSESLARLKWVKNVQGIDLTRDCIMVAKEHAKKDPMLEGKINYECKALEDVTGQFDIITCMEMLEHVDMPSEILRHCWSRLNPEKGILFLSTINRDLISWFTTIFMGENVLKIVPKGTHHLSKYINSKEILAWFNDNYSGQFRLLDLKGTMYLPYQGWVEHDCSDVGNYFMAIQRLN"},{"created_at":"2011-05-26T17:19:36.000Z","updated_at":"2011-07-22T17:54:19.000Z","name":"Biotin synthase, mitochondrial","uniprot_id":"P32451","uniprot_name":"BIOB_YEAST","enzyme":true,"transporter":false,"gene_name":"BIO2","num_residues":375,"molecular_weight":"41883.80078","theoretical_pi":"8.66","general_function":"Involved in catalytic activity","specific_function":"Dethiobiotin + sulfur + 2 S-adenosyl-L- methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine","reactions":[{"id":1347,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2472,"direction":"\u003e","locations":"Mitochondrion","altext":"Dethiobiotin + sulfur + 2 S-adenosyl-L-methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine.","export":false,"pw_reaction_id":null,"source":null},{"id":3756,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006280","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"Z73071","genbank_protein_id":"1323523","gene_card_id":"BIO2","chromosome_location":"chromosome 7","locus":"YGR286C","synonyms":[],"enzyme_classes":["2.8.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring sulfur-containing groups"},{"category":"Function","description":" sulfurtransferase activity"},{"category":"Function","description":" biotin synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" vitamin metabolic process"},{"category":"Process","description":" water-soluble vitamin metabolic process"},{"category":"Process","description":" biotin metabolic process"},{"category":"Process","description":" biotin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" small molecule metabolic process"}],"pfams":[{"name":"Radical_SAM","identifier":"PF04055"},{"name":"BATS","identifier":"PF06968"}],"pathways":[{"name":"Biotin metabolism","kegg_map_id":"00780"},{"name":"Biotin Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGATGTCTACTATCTACCGTCATTTATCTACCGCTAGACCGGCTTTAACTAAATACGCAACCAATGCCGCAGTTAAATCGACAACTGCATCCTCAGAAGCTAGTACTCTGGGTGCTCTACAATATGCATTGTCTTTAGATGAACCAAGTCATTCGTGGACAAAATCGCAATTAAAAGAAATTTATCATACCCCACTGCTCGAACTTACTCATGCAGCACAATTGCAGCACAGAAAGTGGCACGATCCAACCAAAGTGCAATTGTGCACATTGATGAACATCAAATCTGGTGGTTGTTCTGAGGACTGTAAGTATTGTGCGCAGTCTTCGAGAAACGATACCGGTCTAAAGGCTGAGAAAATGGTTAAAGTGGATGAAGTGATTAAAGAGGCAGAAGAGGCCAAAAGAAACGGATCTACTAGATTCTGCCTAGGTGCTGCATGGAGAGACATGAAAGGTCGTAAATCAGCCATGAAAAGAATTCAGGAAATGGTGACCAAAGTGAATGATATGGGGCTAGAAACGTGTGTTACTTTAGGTATGGTTGATCAAGATCAAGCAAAGCAATTGAAAGATGCAGGTTTGACTGCATACAACCATAACATCGACACTTCCAGAGAACACTATAGTAAGGTCATCACCACGAGAACCTACGACGACAGGTTACAGACCATCAAGAATGTCCAAGAATCTGGAATAAAAGCCTGTACCGGTGGTATTTTGGGTCTCGGTGAAAGCGAAGACGACCATATAGGATTCATCTACACATTATCCAATATGTCTCCTCATCCTGAGTCCCTACCAATTAATAGACTAGTTGCTATCAAAGGGACTCCAATGGCTGAGGAACTTGCCGATCCAAAGAGTAAAAAGTTGCAATTCGACGAAATTTTGAGAACCATTGCCACAGCGAGAATAGTTATGCCAAAGGCCATTATAAGACTTGCCGCTGGTCGTTATACAATGAAAGAAACAGAGCAATTTGTCTGTTTCATGGCAGGTTGTAACAGTATCTTCACCGGTAAGAAAATGCTGACGACAATGTGTAACGGTTGGGACGAAGACAAGGCAATGTTGGCTAAATGGGGATTGCAACCTATGGAGGCATTTAAGTACGACAGATCTTGA","protein_sequence":"MMSTIYRHLSTARPALTKYATNAAVKSTTASSEASTLGALQYALSLDEPSHSWTKSQLKEIYHTPLLELTHAAQLQHRKWHDPTKVQLCTLMNIKSGGCSEDCKYCAQSSRNDTGLKAEKMVKVDEVIKEAEEAKRNGSTRFCLGAAWRDMKGRKSAMKRIQEMVTKVNDMGLETCVTLGMVDQDQAKQLKDAGLTAYNHNIDTSREHYSKVITTRTYDDRLQTIKNVQESGIKACTGGILGLGESEDDHIGFIYTLSNMSPHPESLPINRLVAIKGTPMAEELADPKSKKLQFDEILRTIATARIVMPKAIIRLAAGRYTMKETEQFVCFMAGCNSIFTGKKMLTTMCNGWDEDKAMLAKWGLQPMEAFKYDRS"},{"created_at":"2011-05-26T19:26:29.000Z","updated_at":"2011-07-22T17:54:00.000Z","name":"Adenosylmethionine-8-amino-7-oxononanoate aminotransferase","uniprot_id":"P50277","uniprot_name":"BIOA_YEAST","enzyme":true,"transporter":false,"gene_name":"BIO3","num_residues":480,"molecular_weight":"53708.39844","theoretical_pi":"6.41","general_function":"Involved in transaminase activity","specific_function":"Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor","reactions":[{"id":1274,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2566,"direction":"\u003e","locations":null,"altext":"S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate.","export":false,"pw_reaction_id":null,"source":null},{"id":3754,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006278","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AB200248","genbank_protein_id":"67772574","gene_card_id":"BIO3","chromosome_location":"chromosome 14","locus":"YNR058W","synonyms":["7,8-diamino-pelargonic acid aminotransferase","DAPA AT","DAPA aminotransferase","Diaminopelargonic acid synthase"],"enzyme_classes":["2.6.1.62"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" adenosylmethionine-8-amino-7-oxononanoate transaminase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" cofactor binding"},{"category":"Process","description":" vitamin metabolic process"},{"category":"Process","description":" water-soluble vitamin metabolic process"},{"category":"Process","description":" biotin metabolic process"},{"category":"Process","description":" biotin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"}],"pfams":[{"name":"Aminotran_3","identifier":"PF00202"}],"pathways":[{"name":"Biotin metabolism","kegg_map_id":"00780"},{"name":"Biotin Biosynthesis","kegg_map_id":null}],"gene_sequence":"ATGTCCCAAGAAATTTCATATACACCAGATGTCGCGGAACTGCTAGACTTTGATAAAAAACATATTTGGCATCCTTATACGTCATTGAGTTCACCATTGAACGTTTATCCGGTAAAGAGTGCTCACGGATGCAAGCTGGTGTTGGATACCGACTCACCAGTGGACGTCGAGGTGATCGACGCCATGTCGTCGTGGTGGTGTGTTATTCACGGGTACAATAATCCAGAATTAAATGAGGCCCTTACCAAGCAGATGTTAAAGTTTTCTCACGTCCTTCTTGGTGGATTCACCCATAAAGGAGCTGTGAATCTAGTCCAAAAACTTTTAAAAGTGATTGATGAACCCTCTTTGCAGTACTGTTTCCTCGCAGATTCTGGCTCAGTAGCAGTGGAAGTAGCTTTGAAGATGGCTTTACAATCAAACATGTCAGGGGAAGCTACTAAAAATAGAACAAAATTTTTGACAATCAAGAACGGGTATCATGGTGATACATTTGGCGCTATGAGTGTTTGTGATCCTGAGAATTCTATGCATCATATCTACAACGATCGACTCAGTGAGAACATCTTCGCCCAAGCTCCCTCTATTGTCGATGGTCTTCCAACCAGCCAGAACGGTTTCGAGGACCATTGGAATGCAGAAGAAGTTACCGATCTCAAGAAGCAATTTGAATTGCATAGTGATGAGATCTGTGCTGTGATTTTGGAGCCTATCTTACAGGGTGCAGGAGGTTTGCGACCATACCATCCACAGTTCCTAATTGAAGTTCAGAAACTATGTAACCAATACGACGTTTTATTCATCATGGACGAGATTGCTACGGGATTTGGTAGAACAGGTGAGATTTTCGCATTCAAGCACTGTCAAAAATACCAGGACCAACGTGGCATCAGTCCTTCCGATCAGATCAAAGTTGTTCCTGACATATTGTGCGTTGGGAAGGGCTTAACCAGTGGATATATGACTATGAGTGCAGTGGTAGTCAACGACAAAGTTGCTTCCAGAATCTCTTCTCCAAATAGCCCTACTGGTGGCTGCTTCATGCATGGCCCCACCTTCATGGGCAATGCCCTGGCATGCAGTGTGGCAGAAAAGTCTATGGATATACTACTGCGTGGCGAGTGGAGAAAACAAGTGTCTGCAATTGAAGACCAAATTTATAGAGAACTATACCAGTACATCAAGAACCCAGATAATGGGCTCATTGGAACTGTTGTTAAGCGTGTGTCAGTTATTGGAGCTGTAGGTATCGTAGAGCTATACAAGAAGACAGATCCCGAGTGGTTCCAGAAAAAGTTTATATCCAAGGGAGTACATATCCGACCTTTCAACTGCCTGTGTTACATTATGCCACCATATGTGATCACGACAGAGGAATTGACGAAGGTTAATCAAGTCTTGATTGAAGTATTACATGAGTGGAAATCCCACATAAACCAATGA","protein_sequence":"MSQEISYTPDVAELLDFDKKHIWHPYTSLSSPLNVYPVKSAHGCKLVLDTDSPVDVEVIDAMSSWWCVIHGYNNPELNEALTKQMLKFSHVLLGGFTHKGAVNLVQKLLKVIDEPSLQYCFLADSGSVAVEVALKMALQSNMSGEATKNRTKFLTIKNGYHGDTFGAMSVCDPENSMHHIYNDRLSENIFAQAPSIVDGLPTSQNGFEDHWNAEEVTDLKKQFELHSDKICAVILEPILQGAGGLRPYHPQFLIEVQKLCNQYDVLFIMDEIATGFGRTGEIFAFKHCQKYQDQHGISPSDQIKVVPDILCVGKGLTSGYMTMSAVVVNDKVASRISSPNSPTGGCFMHGPTFMGNALACSVAEKSMDILLRGEWRKQVSAIENQIYRELYQYIKNPDNGLIGTVVKRVSVIGAVGIVELYKKTDPEWFQKKFISKGVHIRPFNCLCYIMPPYVITTEELTKVNQVLIEVLHEWKSHINQ"},{"created_at":"2011-05-26T19:35:43.000Z","updated_at":"2011-05-27T15:01:07.000Z","name":"S-adenosylmethionine synthase 1","uniprot_id":"P10659","uniprot_name":"METK1_YEAST","enzyme":true,"transporter":false,"gene_name":"SAM1","num_residues":382,"molecular_weight":"41818.0","theoretical_pi":"4.83","general_function":"Involved in methionine adenosyltransferase activity","specific_function":"Catalyzes the formation of S-adenosylmethionine from methionine and ATP","reactions":[{"id":1728,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2580,"direction":"\u003e","locations":"","altext":"ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.","export":false,"pw_reaction_id":null,"source":null},{"id":3761,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006285","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"J03477","genbank_protein_id":"172534","gene_card_id":"SAM1","chromosome_location":"chromosome 12","locus":"YLR180W","synonyms":["AdoMet synthase 1","Methionine adenosyltransferase 1","MAT 1"],"enzyme_classes":["2.5.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" methionine adenosyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Process","description":" one-carbon metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"S-AdoMet_synt_C","identifier":"PF02773"},{"name":"S-AdoMet_synt_M","identifier":"PF02772"},{"name":"S-AdoMet_synt_N","identifier":"PF00438"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGGCCGGTACATTTTTATTCACTTCTGAATCCGTTGGTGAAGGTCACCCAGATAAGATCTGTGACCAAGTTTCCGACGCCATCTTGGACGCTTGTTTAGCCGAGGACCCTCACTCCAAAGTTGCGTGTGAAACCGCGGCAAAGACTGGTATGATTATGGTCTTTGGTGAAATTACTACCAAGGCACAGTTGGATTACCAAAAAATCGTCAGAGACACCATCAAGAAGATTGGTTACGATGATTCCGCCAAGGGTTTCGACTATAAGACCTGTAACGTCCTTGTCGCCATTGAGCAACAATCTCCAGATATCGCCCAAGGTGTCCACGAGGAGAAGGATTTGGAAGACATCGGTGCCGGTGACCAAGGTATCATGTTTGGTTACGCCACAGATGAAACTCCAGAGGGTTTGCCTTTGACTATTCTTTTGGCTCATAAACTAAACATGGCCATGGCTGACGCGAGAAGAGATGGCTCTTTAGCGTGGTTGAGACCAGACACCAAGACTCAAGTCACCGTCGAATACAAGGATGACCACGGTAGATGGGTTCCACAAAGAATCGACACCGTCGTCGTCTCCGCTCAACATGCTGACGAAATCACGACCGAGGACTTAAGAGCGCAACTAAAGTCCGAGATCATTGAAAAAGTCATCCCAAGAGACATGTTGGACGAAAACACCAAATACTTTATCCAACCTTCCGGTAGATTCGTCATCGGTGGTCCTCAAGGTGACACTGGTTTGACCGGTAGAAAGATCATCGTCGACGCTTACGGTGGTGCCTCATCCGTCGGTGGTGGTGCCTTCTCCGGTAAGGACTACTCTAAGGTTGATCGTTCTGCCGCTTATGCCGCTAGATGGGTTGCCAAGTCCCTAGTTGCCGCTGGTTTATGTAAGAGAGTTCAAGTTCAATTTTCTTATGCCATCGGTATTGCGGAACCATTGTCCTTGCACGTTGACACCTATGGTACTGCGACCAAGTCTGACGAAGAAATTATCGACATTATCAGCAAGAACTTTGACTTGAGACCTGGTGTATTGGTCAAGGAGTTGGACTTAGCTAGACCATTCTACTTGCCAACCGCTTCTTATGGCCATTTCACAAACCAAGAATACCCATGGGAAAAGCCTAAGACTTTGAAGTTCTAA","protein_sequence":"MAGTFLFTSESVGEGHPDKICDQVSDAILDACLAEDPHSKVACETAAKTGMIMVFGEITTKAQLDYQKIVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGVHEEKDLEDIGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLAWLRPDTKTQVTVEYKDDHGRWVPQRIDTVVVSAQHADEITTEDLRAQLKSEIIEKVIPRDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDEEIIDIISKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYPWEKPKTLKF"},{"created_at":"2011-05-27T02:12:57.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Lipoyl synthase, mitochondrial","uniprot_id":"P32875","uniprot_name":"LIPA_YEAST","enzyme":true,"transporter":false,"gene_name":"LIP5","num_residues":414,"molecular_weight":"46246.80078","theoretical_pi":"10.05","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (Probable)","reactions":[{"id":2662,"direction":"\u003e","locations":"Mitochondrion","altext":"Protein N(6)-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosine.","export":false,"pw_reaction_id":null,"source":null},{"id":14866,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007053","source":"Smpdb"},{"id":14867,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007054","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY558046","genbank_protein_id":"45269982","gene_card_id":"LIP5","chromosome_location":"chromosome 15","locus":"YOR196C","synonyms":["Lipoate synthase","LS","Lip-syn","Lipoic acid synthase"],"enzyme_classes":["2.8.1.8"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" 4 iron, 4 sulfur cluster binding"},{"category":"Function","description":" transferase activity, transferring sulfur-containing groups"},{"category":"Function","description":" sulfurtransferase activity"},{"category":"Function","description":" lipoate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" lipoic acid metabolic process"},{"category":"Process","description":" lipoic acid biosynthetic process"},{"category":"Process","description":" lipoate biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"}],"pfams":[{"name":"Radical_SAM","identifier":"PF04055"}],"pathways":[{"name":"Lipoic acid metabolism","kegg_map_id":"00785"}],"gene_sequence":"ATGTATAGACGATCTGTTGGAGTACTATTTGTTGGGAGAAATACAAGATGGATTTCGTCCACTATTAGGTGTGGAACGAGCGCAACTCGGCCAATAAGATCCAATGCATTGAATACTGATTCAGATAACGCTAGCGTTAGGGTACCAGTTGGAAATTCAACTGAGGTTGAAAATGCAACCAGTCAGTTAACAGGGACTTCGGGAAAAAGACGCAAGGGGAACAGAAAAAGAATTACAGAGTTCAAAGATGCTCTTAATTTGGGTCCATCTTTTGCAGATTTTGTTTCAGGTAAAGCTTCGAAAATGATCTTGGACCCTCTGGAGAAGGCAAGGCAAAATACAGAGGAAGCTAAAAAACTACCTCGTTGGCTTAAGGTTCCTATTCCTAAGGGTACCAATTACCATAAATTGAAAGGCGACGTAAAAGAATTAGGCCTGAGTACTGTTTGTGAGGAGGCAAGATGTCCCAATATTGGTGAATGTTGGGGAGGCAAAGATAAATCTAAGGCAACGGCAACAATTATGCTGCTTGGTGATACTTGCACTCGTGGATGTAGGTTTTGTTCTGTGAAGACCAATAGAACGCCTAGTAAGCCGGACCCAATGGAGCCCGAAAATACTGCCGAAGCTATCAAAAGATGGGGGTTGGGTTATGTTGTTTTAACTACCGTTGATAGGGACGATTTAGTCGATGGTGGTGCTAATCACCTGGCCGAGACGGTTCGCAAAATCAAACAGAAGGCACCAAATACTCTTGTAGAGACTCTTTCTGGTGATTTCAGAGGTGATTTGAAGATGGTGGACATTATGGCACAATGTGGGCTTGATGTTTACGCACATAATTTGGAAACAGTTGAATCACTAACACCACATGTCAGAGACAGAAGAGCTACTTATAGACAGTCTTTGAGTGTTTTAGAAAGGGCAAAAGCTACGGTTCCGTCACTGATTACTAAAACATCAATAATGCTGGGTCTAGGAGAAACTGATGAGCAAATTACTCAAACTTTGAAGGATTTGCGCAATATTCAATGTGATGTTGTTACATTTGGTCAATATATGAGGCCAACCAAGAGACATATGAAAGTCGTAGAATATGTGAAACCCGAAAAGTTTGACTACTGGAAAGAGAGAGCTTTAGAGATGGGATTCTTGTATTGTGCATCTGGACCCCTAGTAAGATCGTCATATAAGGCTGGTGAAGCATTTATTGAGAACGTTTTGAAGAAAAGAAACATGAAATAA","protein_sequence":"MYRRSVGVLFVGRNTRWISSTIRCGTSATRPIRSNALNTDSDNASVRVPVGNSTEVENATSQLTGTSGKRRKGNRKRITEFKDALNLGPSFADFVSGKASKMILDPLEKARQNTEEAKKLPRWLKVPIPKGTNYHKLKGDVKELGLSTVCEEARCPNIGECWGGKDKSKATATIMLLGDTCTRGCRFCSVKTNRTPSKPDPMEPENTAEAIKRWGLGYVVLTTVDRDDLVDGGANHLAETVRKIKQKAPNTLVETLSGDFRGDLKMVDIMAQCGLDVYAHNLETVESLTPHVRDRRATYRQSLSVLERAKATVPSLITKTSIMLGLGETDEQITQTLKDLRNIQCDVVTFGQYMRPTKRHMKVVEYVKPEKFDYWKERALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRNMK"},{"created_at":"2011-05-27T02:13:35.000Z","updated_at":"2011-07-22T17:53:47.000Z","name":"Trans-aconitate 3-methyltransferase","uniprot_id":"P32643","uniprot_name":"TMT1_YEAST","enzyme":true,"transporter":false,"gene_name":"TMT1","num_residues":299,"molecular_weight":"34768.0","theoretical_pi":"6.18","general_function":"Involved in methyltransferase activity","specific_function":"Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation","reactions":[{"id":1181,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2014,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2663,"direction":"\u003e","locations":"Cytoplasm","altext":"S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U18922","genbank_protein_id":"603416","gene_card_id":"TMT1","chromosome_location":"chromosome 5","locus":"YER175C","synonyms":[],"enzyme_classes":["2.1.1.145"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Methyltransf_11","identifier":"PF08241"}],"pathways":[],"gene_sequence":"ATGTCTACCTTTTCTGCTTCTGATTTCAACTCAGAAAGATATTCATCTTCAAGACCTTCTTATCCCTCCGATTTTTACAAGATGATTGATGAATACCACGACGGAGAAAGGAAATTACTCGTAGATGTTGGCTGTGGACCAGGTACTGCCACTTTACAAATGGCTCAGGAGTTAAAACCATTCGAACAAATTATCGGAAGCGATCTCTCCGCTACCATGATTAAGACTGCAGAAGTAATAAAGGAAGGAAGTCCTGATACATACAAAAACGTTTCATTTAAGATTTCTTCAAGTGATGATTTTAAATTCCTAGGCGCGGATTCAGTAGACAAACAGAAAATTGATATGATTACCGCAGTAGAATGTGCTCATTGGTTCGATTTCGAAAAATTTCAGCGATCTGCTTATGCCAATTTGAGAAAAGATGGTACTATCGCTATTTGGGGTTATGCGGACCCAATTTTCCCGGACTACCCTGAATTTGATGATCTGATGATTGAAGTTCCTTACGGGAAGCAAGGACTGGGACCCTATTGGGAACAACCGGGGAGATCTCGCCTTCGTAATATGCTGAAAGACTCTCACTTAGACCCAGAACTTTTCCATGATATACAAGTTTCATATTTTTGTGCAGAAGATGTGAGAGACAAAGTAAAACTCCACCAGCATACAAAGAAGCCATTGCTAATCAGAAAGCAGGTCACCCTAGTGGAGTTTGCAGATTATGTCAGAACCTGGAGCGCTTACCATCAGTGGAAGCAGGATCCAAAGAACAAAGATAAAGAAGATGTAGCAGATTGGTTTATTAAAGAGTCACTAAGGAGGAGGCCGGAACTTTCCACCAACACCAAAATTGAAGTTGTTTGGAATACTTTTTACAAACTTGGCAAAAGGGTCTGA","protein_sequence":"MSTFSASDFNSERYSSSRPSYPSDFYKMIDEYHDGERKLLVDVGCGPGTATLQMAQELKPFEQIIGSDLSATMIKTAEVIKEGSPDTYKNVSFKISSSDDFKFLGADSVDKQKIDMITAVECAHWFDFEKFQRSAYANLRKDGTIAIWGYADPIFPDYPEFDDLMIEVPYGKQGLGPYWEQPGRSRLRNMLKDSHLDPELFHDIQVSYFCAEDVRDKVKLHQHTKKPLLIRKQVTLVEFADYVRTWSAYHQWKQDPKNKDKEDVADWFIKESLRRRPELSTNTKIEVVWNTFYKLGKRV"},{"created_at":"2011-05-27T02:19:33.000Z","updated_at":"2011-07-22T17:54:00.000Z","name":"S-adenosylmethionine decarboxylase proenzyme","uniprot_id":"P21182","uniprot_name":"DCAM_YEAST","enzyme":true,"transporter":false,"gene_name":"SPE2","num_residues":396,"molecular_weight":"46232.0","theoretical_pi":"5.32","general_function":"Involved in adenosylmethionine decarboxylase activity","specific_function":"S-adenosylmethionine decarboxylase is essential for normal growth, sporulation, maintenance of ds-RNA virus, biosynthesis of spermine and spermidine","reactions":[{"id":1273,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2671,"direction":"\u003e","locations":null,"altext":"S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3760,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006284","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M38434","genbank_protein_id":"171055","gene_card_id":"SPE2","chromosome_location":"chromosome 15","locus":"YOL052C","synonyms":["AdoMetDC","SAMDC","S-adenosylmethionine decarboxylase alpha chain","S-adenosylmethionine decarboxylase beta chain"],"enzyme_classes":["4.1.1.50"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenosylmethionine decarboxylase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" spermidine biosynthetic process"},{"category":"Process","description":" polyamine metabolic process"},{"category":"Process","description":" polyamine biosynthetic process"},{"category":"Process","description":" spermine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"SAM_decarbox","identifier":"PF01536"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"}],"gene_sequence":"ATGACTGTCACCATAAAAGAATTGACTAACCACAACTACATTGACCACGAACTATCAGCCACTTTAGACTCAACGGATGCGTTCGAGGGTCCCGAGAAGTTGCTGGAAATCTGGTTCTTCCCTCACAAGAAGTCCATCACGACCGAAAAGACATTAAGAAATATTGGCATGGATAGATGGATCGAGATTTTGAAATTAGTGAAATGCGAAGTTCTTTCCATGAAGAAGACTAAAGAACTGGATGCCTTTTTGTTGAGTGAGTCTTCCCTCTTCGTCTTCGATCACAAATTGACGATGAAGACGTGCGGTACTACAACCACATTGTTCTGTCTCGAAAAGCTTTTCCAGATCGTTGAGCAAGAGTTATCGTGGGCTTTCCGCACAACACAAGGGGGCAAGTACAAACCATTTAAAGTGTTTTATTCTAGACGATGTTTCCTTTTCCCCTGTAAGCAAGCCGCTATCCATCAAAACTGGGCTGACGAAGTCGACTATTTGAACAAATTTTTCGACAATGGTAAAAGTTATTCCGTGGGAAGAAATGACAAGAGCAACCACTGGAACCTGTACGTCACCGAGACGGACCGCTCCACACCTAAGGGAAAGGAGTACATCGAGGATGACGACGAAACTTTCGAAGTACTGATGACGGAGCTGGACCCAGAATGCGCTAGTAAGTTTGTTTGCGGGCCTGAGGCATCCACAACCGCTCTCGTGGAGCCAAACGAAGATAAGGGCCACAACCTCGGCTACCAAATGACTAAAAATACAAGGCTTGACGAAATATATGTCAACTCGGCCCAAGACTCCGATTTATCATTTCACCACGATGCATTTGCGTTCACGCCATGTGGATACTCATCCAATATGATTCTCGCTGAAAAATACTATTACACCCTGCACGTGACTCCGGAAAAGGGTTGGTCTTACGCCTCTTTCGAAAGTAACATACCCGTATTTGACATTTCCCAAGGGAAGCAAGACAACTTGGACGTTCTTCTACATATTCTGAACGTTTTTCAACCAAGAGAGTTCTCGATGACCTTTTTTACCAAAAATTATCAGAACCAATCCTTCCAAAAACTACTAAGCATCAACGAGTCACTGCCCGACTACATCAAGTTAGACAAAATTGTTTATGATCTGGACGACTACCACCTTTTCTATATGAAATTGCAGAAGAAAATATGA","protein_sequence":"MTVTIKELTNHNYIDHELSATLDSTDAFEGPEKLLEIWFFPHKKSITTEKTLRNIGMDRWIEILKLVKCEVLSMKKTKELDAFLLSESSLFVFDHKLTMKTCGTTTTLFCLEKLFQIVEQELSWAFRTTQGGKYKPFKVFYSRRCFLFPCKQAAIHQNWADEVDYLNKFFDNGKSYSVGRNDKSNHWNLYVTETDRSTPKGKEYIEDDDETFEVLMTELDPECASKFVCGPEASTTALVEPNEDKGHNLGYQMTKNTRLDEIYVNSAQDSDLSFHHDAFAFTPCGYSSNMILAEKYYYTLHVTPEKGWSYASFESNIPVFDISQGKQDNLDVLLHILNVFQPREFSMTFFTKNYQNQSFQKLLSINESLPDYIKLDKIVYDLDDYHLFYMKLQKKI"},{"created_at":"2011-05-27T02:37:10.000Z","updated_at":"2011-05-29T05:06:36.000Z","name":"Ubiquinone biosynthesis protein COQ4, mitochondrial","uniprot_id":"O13525","uniprot_name":"COQ4_YEAST","enzyme":true,"transporter":false,"gene_name":"COQ4","num_residues":335,"molecular_weight":"38626.80078","theoretical_pi":"10.13","general_function":"Involved in ubiquinone biosynthetic process","specific_function":"Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides","reactions":[],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Peripheral membrane protein; Matrix side","genbank_gene_id":"Z68194","genbank_protein_id":"1204149","gene_card_id":"COQ4","chromosome_location":"chromosome 4","locus":"YDR204W","synonyms":["Coenzyme Q biosynthesis protein 4"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" oxidoreduction coenzyme metabolic process"},{"category":"Process","description":" ubiquinone metabolic process"},{"category":"Process","description":" ubiquinone biosynthetic process"}],"pfams":[{"name":"Coq4","identifier":"PF05019"}],"pathways":[],"gene_sequence":"ATGTTGAGGTTATCTTTACTGAGATCAACAGCTACTTTGCCAGTGAAATGCCAACGTCGTGGGCTAATATTACCTGCGGCGGCAATGTACACCTTAGGCTCATTAATATTTGGTAAGGAAGCAAGGTTGGCGGATGCCATGGAACGTGGTGAGTTACATAACAAGAACGTTGATTATGCGAAAGAAGCTGAAGAGCGTACCGAGTTACGTATTAGGGCCCTGGCTAATACTCGGCCAATGGAACCTCGGTACAACGGCCATGTTCCCCTTCATCGGTACGAGAAATTGCTGCTGTTTGCAATTTCCGGTTGGAATTCATTTTTCCATCCTGAAGATGGTTATAATATTGTACAATTGGGTGAGGCAACTGCATTGCCGGTCTTCTTGGAGAATTTGAAGCAAACAATGTTAAGTGATTCCTCTGGGAGGCGCATTTTGAAGGAACAACCCAATATCACAACAGAGATTTTGCATATGGACAAACTAGCTAAATTGCCACATAACACGTTTGGGTATGTATATTACCAATGGTTGAAAAGAGAAAACGTTTCTCCGGACACTAGAGCACCTGTCAAATTTATCGACGATCCTATGCATGCATATATCTTTAAGAGGTATAGACAATGCCACGATTTCTATCACGCTATAACCAACATGCCTATTATCATTGAGGGGGAGATCACCATAAAGGCTCTTGAAGGTGCCAACCTGGGCGTCCCAATGGCCATTCTCGGTGGTATCCTTGCACCTTTACGTTTGAAAAAGGTGCAAAGAAAAAGATTATATAATATATATCTCCCTTGGGCTGTCAGAACAGGTTTAAGCTGCAAGCCATTGATCAACGTGTATTGGGAGGAAATGCTGGAGAAGGATGTTACTGCTTTGAGGAAAGAGCTAAAGATAACACTCCCTCCGGATCTAAGGACAATGAGGAAGGAGCGTGCAGCCCTTAGGAAGGAGATTGACGCAAAATACAACTCACAGAAACGAGCCACGACTCCAGCATGA","protein_sequence":"MLRLSLLRSTATLPVKCQRRGLILPAAAMYTLGSLIFGKEARLADAMERGELHNKNVDYAKEAEERTELRIRALANTRPMEPRYNGHVPLHRYEKLLLFAISGWNSFFHPEDGYNIVQLGEATALPVFLENLKQTMLSDSSGRRILKEQPNITTEILHMDKLAKLPHNTFGYVYYQWLKRENVSPDTRAPVKFIDDPMHAYIFKRYRQCHDFYHAITNMPIIIEGEITIKALEGANLGVPMAILGGILAPLRLKKVQRKRLYNIYLPWAVRTGLSCKPLINVYWEEMLEKDVTALRKELKITLPPDLRTMRKERAALRKEIDAKYNSQKRATTPA"},{"created_at":"2011-05-27T03:31:26.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"Cytochrome c lysine N-methyltransferase 1","uniprot_id":"P38818","uniprot_name":"CTM1_YEAST","enzyme":true,"transporter":false,"gene_name":"CTM1","num_residues":585,"molecular_weight":"68283.60156","theoretical_pi":"4.62","general_function":"Involved in [cytochrome c]-lysine N-methyltransferase a","specific_function":"Methyltransferase which mediates trimethylation of Lys- 77 of cytochrome c (CYC1)","reactions":[{"id":2726,"direction":"\u003e","locations":"Cytoplasm, cytosol","altext":"S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm, cytosol","genbank_gene_id":"AY723824","genbank_protein_id":"51830380","gene_card_id":"CTM1","chromosome_location":"chromosome 8","locus":"YHR109W","synonyms":[],"enzyme_classes":["2.1.1.59"],"go_classes":[],"pfams":[],"pathways":[{"name":"Lysine degradation","kegg_map_id":"00310"}],"gene_sequence":"ATGGAGGAAGTGTTCCGTTTTTACTCGAACTCTAGAAATATCTTCATTCATAAAAGCCTTTCATTAAAACCATCCACCATTGATGACCCCAAAAGTGGGTATGGCCTTTTCGTAGAACCTTCGAAGTTCAAGAATGATGAATTGAAAAGTGAAACTATCCAATTGCTCCGAATCCCTAAGCGCTGCACGTTTAATATAAACACACTTCTGGCTCTCTTGGGAGATGAGGACGAATTTTCCTCAAAGGAAGAATTTCAAAGAACTAATGACAAAATTAAGATTGCTCTTCGTGAAATAATGGCTCATCCGAATTTCAGTGTGTTCCTGACAGAAACAAATTTACTCATAATTTATTTCATGATATTTCAAACTATTCGTAGTCGTTATGAGATTCCCGAAAATATCCAATATTATTTAGAAAATGTTTTAATGAGCATTGAAGTAGAAACAGCCATGGATTCTATTGAAAACTTAGCTACTGATTATGGACATTATCCACAGATTTTTGGCCTTCGAGAGACGCTAAATTTATTTAAAGAACTGTTTCACGACGTCTTGAATTTAAGTGATATCAAACATCTTTATTCTGCAATAATTTCACGTTGTTTAGAGATACCAGAAAGGGCCGATACCAAAAGTGAAGAATTCACGGTCCATTCTACTTTAGTCCCTATTGTAGATTTTGCCAACCATGAAGGCACCCAAAAAAATGCTTATTTTGACATCGACCCTTCAAATAATGACGTTTTACTTCTATTGGATACAAGAGCGGTCCAAAGTGAACTCACAAAACCTATTGAAGTTTTCATTAGTTACTCACCAACAGAGGATTTATTTTCCATGCTTGTAACATATGGATTCACCCCAGATTTTAGAGGGAATTCCCAATTTTGGACTGTATCCTTTGACAGGTGCTTTTTAAGAAACTATGATGGACCAGATAAAACTACAAATTTAAGATTGTTTTACAAATGGATGCACATAAATCCAGTGGTACCACTAGTTAAATACGAGCACAACGGAAAGACTCGCTGGTTTCTCAATGACACCACGCCTGAATTTGATATGCTTTTGCTCCCATTCATTCCATCGATAGATGATGGCAAAATTGCTCGGTGGGCGTACGATTCCACATGTCATTTGATGTTCACGAAAATCCATTGTCTGATAAATCCCGAGGCCAACGAACATGCGTTAATGATTGCAGAAAACTACCGCTCTCTCATTAAAGAGAAAGAGTCAAATGGTGACGATTTCATAAATTTACCGCCACTAGCTTGGTCATTGCGTTACAAAGATACAGAAAACGATTGTGTACGGCAAAGACATATATGCAGTGAAGATGCGGTCGCTGTACTTAAACAAGAAGAAATGCAAGACTCAACCAAAACCAAATCCCAGTTTACCAGTTTCTTTCGTAAATTTTTAGAGTTTCGTAGATCCAAAATTATTAGGCCTACCAGTGATTCAAAAGTTGCAAGCATATTATACCAGCAGGAACTGGAAATAATTGCTGACTTAGCAAAAGCTATCGATAGCAGCTCTACCATTTTTTTCAGCGATCTGAATGTTACATTGGACACCGAACCAGAACGGCTCCCCCCTCTAAGGTTTTTAGATGATTACATAGAGATCTCTGCGGATAAGCAGGAGCCAAGCCCAATTTGTGAGGATCTTTCTTATTATACACCCAGCAGGTTTACTGATTTTTTTCAAGAAGAGGTAAGCCAATATGCGGCTTTCTTTCAGGATGACTAG","protein_sequence":"MEEVFRFYSNSRNIFIHKSLSLKPSTIDDPKSGYGLFVEPSKFKNDELKSETIQLLRIPKRCTFNINTLLALLGDEDEFSSKEEFQRTNDKIKIALREIMAHPNFSVFLTETNLLIIYFMIFQTIRSRYEIPENIQYYLENVLMSIEVETAMDSIENLATDYGHYPQIFGLRETLNLFKELFHDVLNLSDIKHLYSAIISRCLEIPERADTKSEEFTVHSTLVPIVDFANHEGTQKNAYFDIDPSNNDVLLLLDTKAVQSELTKPIEVFISYSPTEDLFSMLVTYGFTPDFRGNSQFWTVSFDRCFLRNYDGPDKTTNLRLFYKWMHINPVVPLVKYEHNGKTRWFLNDTTPEFDMLLLPFIPSIDDGKIARWAYDSTCHLMFTKIHCLINPEANEHALMIAENYRSLIKEKESNGDDFINLPPLAWSLRYKDTENDCVRQRHICSEDAVAVLKQEEMQDSTKTKSQFTSFFRKFLEFRRSKIIRPTSDSKVASILYQQELEIIADLAKAIDSSSTIFFSDLNVTLDTEPERLPPLRFLDDYIEISADKQEPSPICEDLSYYTPSRFTDFFQEEVSQYAAFFQDD"},{"created_at":"2011-05-27T03:32:46.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"tRNA (guanine-N(1)-)-methyltransferase TRM10","uniprot_id":"Q12400","uniprot_name":"TRM10_YEAST","enzyme":true,"transporter":false,"gene_name":"TRM10","num_residues":293,"molecular_weight":"34520.19922","theoretical_pi":"9.81","general_function":"Involved in methyltransferase activity","specific_function":"Catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNAs","reactions":[{"id":2728,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm (Probable)","altext":"S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N(1)-methylguanine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"X83121","genbank_protein_id":"600465","gene_card_id":"TRM10","chromosome_location":"chromosome 15","locus":"YOL093W","synonyms":["tRNA methyltransferase 10"],"enzyme_classes":["2.1.1.31"],"go_classes":[],"pfams":[{"name":"tRNA_m1G_MT","identifier":"PF01746"}],"pathways":[],"gene_sequence":"ATGTCCAATGATGAGATAAACCAGAACGAGGAAAAGGTGAAAAGAACACCACCTTTACCGCCTGTGCCAGAAGGCATGTCTAAAAAGCAATGGAAAAAAATGTGTAAAAGACAGAGATGGGAGGAGAATAAAGCCAAATACAATGCGGAACGCCGTGTAAAGAAGAAGAGACTTCGCCATGAAAGAAGTGCGAAGATTCAAGAATACATTGACAGGGGAGAAGAGGTCCCGCAGGAATTGATTAGAGAGCCTCGTATCAATGTGAATCAGACTGATTCTGGGATAGAGATCATACTTGACTGTTCTTTTGATGAGTTAATGAACGACAAGGAAATAGTAAGCTTGTCTAACCAGGTCACCAGGGCATACTCCGCGAATAGAAGGGCGAACCATTTTGCAGAAATAAAGGTGGCCCCATTCGACAAAAGACTAAAGCAAAGGTTTGAAACTACTCTGAAAAATACCAATTATGAAAACTGGAACCATTTTAAATTCCTACCAGACGACAAAATCATGTTTGGAGATGAGCATATAAGTAAGGACAAAATAGTGTATTTAACGGCCGATACAGAGGAAAAGCTGGAGAAGCTGGAACCCGGGATGCGATACATTGTTGGCGGCATTGTAGACAAGAATCGTTATAAAGAATTGTGTCTGAAGAAGGCCCAAAAGATGGGCATTCCTACGCGAAGATTGCCCATTGACGAGTACATCAATCTCGAAGGCAGAAGAGTGTTGACGACAACGCACGTCGTGCAACTCATGCTGAAATACTTTGATGACCATAACTGGAAAAATGCCTTTGAAAGCGTTTTACCACCCAGAAAGCTGGATGCGGAAGCAAAATCCGCAAGCTCTTCGCCAGCTCCAAAGGACACATAG","protein_sequence":"MSNDEINQNEEKVKRTPPLPPVPEGMSKKQWKKMCKRQRWEENKAKYNAERRVKKKRLRHERSAKIQEYIDRGEEVPQELIREPRINVNQTDSGIEIILDCSFDELMNDKEIVSLSNQVTRAYSANRRANHFAEIKVAPFDKRLKQRFETTLKNTNYENWNHFKFLPDDKIMFGDEHISKDKIVYLTADTEEKLEKLEPGMRYIVGGIVDKNRYKELCLKKAQKMGIPTRRLPIDEYINLEGRRVLTTTHVVQLMLKYFDDHNWKNAFESVLPPRKLDAEAKSASSSPAPKDT"},{"created_at":"2011-05-27T03:33:20.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61","uniprot_id":"P46959","uniprot_name":"TRM61_YEAST","enzyme":true,"transporter":false,"gene_name":"GCD14","num_residues":383,"molecular_weight":"43919.30078","theoretical_pi":"7.66","general_function":"Involved in tRNA (adenine-N1-)-methyltransferase activity","specific_function":"Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. GCD14 is also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency","reactions":[{"id":2729,"direction":"\u003e","locations":"Nucleus","altext":"S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N(1)-methyladenine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"Z49400","genbank_protein_id":"1008322","gene_card_id":"GCD14","chromosome_location":"chromosome 10","locus":"YJL125C","synonyms":["General control non-derepressible protein 14","Protein GCD14","tRNA(m1A58)-methyltransferase subunit TRM61","tRNA(m1A58)MTase subunit TRM61"],"enzyme_classes":["2.1.1.36"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" RNA methyltransferase activity"},{"category":"Function","description":" tRNA methyltransferase activity"},{"category":"Function","description":" tRNA (adenine) methyltransferase activity"},{"category":"Function","description":" tRNA (adenine-N1-)-methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" RNA modification"},{"category":"Process","description":" RNA methylation"},{"category":"Process","description":" tRNA methylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"}],"pfams":[{"name":"GCD14","identifier":"PF08704"}],"pathways":[],"gene_sequence":"ATGTCAACAAATTGTTTTTCCGGTTACAAAGACCTCATCAAGGAAGGCGATTTAACTCTAATATGGGTTTCTAGAGATAACATCAAACCGGTAAGGATGCATTCCGAAGAGGTATTCAATACTCGTTATGGTTCATTTCCTCATAAGGATATCATAGGTAAACCTTATGGTTCTCAAATTGCTATAAGAACAAAGGGCTCAAATAAGTTTGCATTCGTCCATGTTCTGCAACCAACTCCTGAATTGTGGACTTTGTCGTTACCACACAGAACTCAAATTGTATATACGCCCGACTCTTCCTACATCATGCAAAGGTTGAATTGTAGCCCTCACAGCAGAGTGATCGAGGCAGGTACAGGCTCAGGATCATTTTCGCACGCTTTTGCAAGATCTGTAGGTCATCTTTTTAGTTTTGAATTTCATCACATAAGATACGAACAAGCATTAGAGGAATTCAAAGAGCATGGACTTATTGATGATAACGTTACGATTACACATCGGGATGTTTGCCAAGGTGGATTTCTTATAAAGAAGGGAGACACTACATCTTACGAATTTGGCAATAATGAAACCGCCGCTTCATTGAATGCAAATGTAGTGTTTTTAGATCTGCCGGCTCCCTGGGATGCTATACCTCATCTGGATTCTGTTATTTCCGTAGACGAAAAGGTCGGATTGTGTTGCTTCTCCCCATGCATTGAGCAAGTAGACAAAACATTGGATGTATTAGAGAAATATGGCTGGACGGATGTTGAAATGGTGGAAATTCAAGGTAGACAGTACGAAAGTCGAAGACAAATGGTCAGATCACTCAATGATGCCCTGGAAAGGTTGAGAGATATTAAGAGGCACAAACTCCAGGGTGTAGAAAGACGCAAGCGGATGTTTAACAATACAATAGATTCTAACGATGAAAAAGTTGGAAAAAGAAACGAGGATGGCGTACCATTAACAGAAAAGGCCAAATTTAATCCTTTTGGCAAAGGTTCTCGAATCAAGGAAGGTGATAGTAATTATAAATGGAAGGAGGTCACAAAGATGGAAGCTGAGATCAAATCCCATACCTCATATTTGACTTTTGCATTTAAAGTTGTGAATAGATCAAGAGATGATGAAAAAGTTAACGAAATTCTTCGATCCACGGAAAAATAA","protein_sequence":"MSTNCFSGYKDLIKEGDLTLIWVSRDNIKPVRMHSEEVFNTRYGSFPHKDIIGKPYGSQIAIRTKGSNKFAFVHVLQPTPELWTLSLPHRTQIVYTPDSSYIMQRLNCSPHSRVIEAGTGSGSFSHAFARSVGHLFSFEFHHIRYEQALEEFKEHGLIDDNVTITHRDVCQGGFLIKKGDTTSYEFGNNETAASLNANVVFLDLPAPWDAIPHLDSVISVDEKVGLCCFSPCIEQVDKTLDVLEKYGWTDVEMVEIQGRQYESRRQMVRSLNDALERLRDIKRHKLQGVERRKRMFNNTIDSNDEKVGKRNEDGVPLTEKAKFNPFGKGSRIKEGDSNYKWKEVTKMEAEIKSHTSYLTFAFKVVNRSRDDEKVNEILRSTEK"},{"created_at":"2011-05-27T03:35:14.000Z","updated_at":"2011-07-22T17:54:22.000Z","name":"Protein-S-isoprenylcysteine O-methyltransferase","uniprot_id":"P32584","uniprot_name":"STE14_YEAST","enzyme":true,"transporter":false,"gene_name":"STE14","num_residues":239,"molecular_weight":"27887.40039","theoretical_pi":"8.11","general_function":"Involved in protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity","specific_function":"Mediates C-terminal methylation of the isoprenylated C- terminal cysteine in A-factor mating pheromone and Ras proteins","reactions":[{"id":2732,"direction":"\u003e","locations":"Membrane; Multi-pass membrane protein (Probable)","altext":"S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"24-44;48-68;89-109;111-131;183-203","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein (Probable)","genbank_gene_id":"L07952","genbank_protein_id":"172018","gene_card_id":"STE14","chromosome_location":"chromosome 4","locus":"YDR410C","synonyms":["Isoprenylcysteine carboxylmethyltransferase","Prenylated protein carboxyl methyltransferase","PPMT","Prenylcysteine carboxyl methyltransferase","pcCMT"],"enzyme_classes":["2.1.1.100"],"go_classes":[{"category":"Component","description":" integral to membrane"},{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" protein methyltransferase activity"},{"category":"Function","description":" protein carboxyl O-methyltransferase activity"},{"category":"Function","description":" protein C-terminal carboxyl O-methyltransferase activity"},{"category":"Function","description":" protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" post-translational protein modification"},{"category":"Process","description":" protein amino acid alkylation"},{"category":"Process","description":" protein amino acid methylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" C-terminal protein amino acid methylation"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"}],"pfams":[{"name":"ICMT","identifier":"PF04140"}],"pathways":[],"gene_sequence":"ATGCACCAAGATTTTCAAGAAGACGAGCATGAGTATCCAGACATCAGACGCAATCCGCTGCATGAGGTGACCATGACTTCCTACATACTGGGGATTCTTTTAGGTATATTTGTTGGTCTTTTTCCACAAATTAGATTCAAGAATTTTAACCTCTTTATTATTGCCCTGTCCTTATTCCATTTTTTGGAGTATTATATTACAGCTAAATACAATCCTCTTAAGGTACATTCAGAGTCCTTTCTTCTGAACAACGGCAAAAGTTACATGGCGGCACATTCCTTTGCTATTCTGGAATGCCTCGTAGAAAGCTTTCTTTTTCCTGATCTGAAAATTTTTAGCTACTCTCTAGCTACCAAGCTTTGTACAGTACTTGGATGTCTTCTAGTTATTCTGGGACAATATACCAGAACTATTGCTATGCATACTGCGGGACATTCCTTTTCTCATATTGTGAAGACCAAGAAGGAGTCCGATCATGTTTTAGTGAAAACTGGCGTTTACTCCTGGTCAAGACATCCAAGTTATCTTGGGTTCTTTTGGTGGGCAATTGGCACTCAGCTACTGCTTCTAAATCCCCTATCATTGGTTATTTTCATTTTTGTACTTTGGAAATTTTTCAGTGATAGAATTCGTGTGGAAGAAAAATATTTGATAGAGTTCTTTAGCGCGGAATACATAGAATACAAGAATAAGGTTGGTGTCGGAATACCTTTTATATAA","protein_sequence":"MHQDFQEDEHEYPDIRRNPLHEVTMTSYILGILLGIFVGLFPQIRFKNFNLFIIALSLFHFLEYYITAKYNPLKVHSESFLLNNGKSYMAAHSFAILECLVESFLFPDLKIFSYSLATKLCTVLGCLLVILGQYTRTIAMHTAGHSFSHIVKTKKESDHVLVKTGVYSWSRHPSYLGFFWWAIGTQLLLLNPLSLVIFIFVLWKFFSDRIRVEEKYLIEFFSAEYIEYKNKVGVGIPFI"},{"created_at":"2011-05-27T03:36:30.000Z","updated_at":"2011-05-27T15:01:20.000Z","name":"HNRNP arginine N-methyltransferase","uniprot_id":"P38074","uniprot_name":"HMT1_YEAST","enzyme":true,"transporter":false,"gene_name":"HMT1","num_residues":348,"molecular_weight":"39785.80078","theoretical_pi":"5.15","general_function":"Involved in protein methyltransferase activity","specific_function":"Methylates arginines in a variety of RNA-binding proteins. Methylates NOP3. Can catalyze both the mono- and asymmetric dimethylation","reactions":[{"id":1634,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1G6Q","cellular_location":null,"genbank_gene_id":"AY557869","genbank_protein_id":"45269629","gene_card_id":"HMT1","chromosome_location":"chromosome 2","locus":"YBR034C","synonyms":["Protein ODP1"],"enzyme_classes":["2.1.1.-"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" protein methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" post-translational protein modification"},{"category":"Process","description":" protein amino acid alkylation"},{"category":"Process","description":" protein amino acid methylation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"}],"pfams":[{"name":"PrmA","identifier":"PF06325"}],"pathways":[],"gene_sequence":"ATGAGCAAGACAGCCGTGAAAGATTCTGCTACAGAAAAAACCAAGCTAAGTGAAAGCGAACAGCACTACTTCAATTCGTACGATCACTATGGTATTCACGAAGAGATGCTTCAAGATACTGTTCGTACCTTATCTTACAGAAACGCAATTATCCAAAATAAGGATCTTTTTAAGGACAAGATTGTTTTAGACGTCGGTTGCGGTACCGGTATTTTATCCATGTTTGCCGCTAAACACGGTGCGAAGCATGTTATCGGTGTTGATATGTCAAGCATTATTGAGATGGCGAAGGAATTGGTAGAGTTGAACGGATTCAGCGACAAGATCACCTTGCTAAGAGGCAAGTTGGAGGACGTTCATTTACCCTTTCCTAAAGTTGACATCATAATTTCTGAATGGATGGGTTACTTTCTACTATACGAGTCCATGATGGACACCGTTCTTTACGCTAGAGACCACTATTTGGTAGAAGGCGGTCTGATCTTTCCCGACAAGTGCTCCATTCATTTGGCCGGTTTGGAAGACTCTCAGTATAAAGACGAGAAGTTGAACTACTGGCAAGACGTTTACGGGTTTGATTATTCGCCATTTGTTCCGTTGGTCTTACACGAGCCCATCGTCGACACCGTGGAAAGAAACAATGTCAACACCACCTCAGACAAATTGATCGAATTTGATTTAAATACAGTAAAAATATCAGATCTAGCGTTTAAGAGTAACTTTAAATTGACGGCCAAGAGACAAGATATGATTAATGGTATAGTCACCTGGTTCGACATTGTTTTCCCTGCACCAAAGGGTAAGAGACCTGTTGAGTTCTCCACTGGTCCTCATGCTCCATACACTCACTGGAAGCAAACAATATTTTATTTCCCTGATGATCTAGATGCTGAAACTGGTGACACCATTGAAGGTGAATTGGTTTGCTCTCCAAACGAGAAGAATAACAGAGATCTAAATATCAAAATTTCTTACAAGTTCGAATCGAATGGCATCGACGGTAATTCAAGAAGCAGAAAAAACGAAGGTTCTTATTTAATGCATTAA","protein_sequence":"MSKTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKFESNGIDGNSRSRKNEGSYLMH"},{"created_at":"2011-05-27T03:41:09.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Homocysteine S-methyltransferase 1","uniprot_id":"Q12525","uniprot_name":"MHT1_YEAST","enzyme":true,"transporter":false,"gene_name":"MHT1","num_residues":324,"molecular_weight":"36714.5","theoretical_pi":"5.26","general_function":"Involved in homocysteine S-methyltransferase activity","specific_function":"Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S- methylmethionine (SMM) to methionine","reactions":[{"id":1637,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2739,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"S-methyl-L-methionine + L-homocysteine = 2 L-methionine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY558194","genbank_protein_id":"45270278","gene_card_id":"MHT1","chromosome_location":"chromosome 12","locus":"YLL062C","synonyms":["S-methylmethionine:homocysteine methyltransferase 1","SMM:Hcy S-methyltransferase 1"],"enzyme_classes":["2.1.1.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" S-methyltransferase activity"},{"category":"Function","description":" homocysteine S-methyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"S-methyl_trans","identifier":"PF02574"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"}],"gene_sequence":"ATGAAGCGCATTCCAATCAAAGAACTAATAGTTGAGCACCCCGGAAAAGTTCTTATCCTTGATGGTGGACAGGGTACAGAATTGGAAAACAGAGGCATTAACATAAATAGTCCGGTATGGTCTGCAGCTCCTTTTACGAGCGAATCCTTTTGGGAGCCATCTTCTCAAGAGCGAAAGGTGGTAGAAGAAATGTACAGAGACTTTATGATTGCTGGCGCAAACATATTAATGACAATTACTTACCAGGCAAACTTTCAAAGCATATCTGAGAATACCTCGATTAAAACTCTGGCTGCTTACAAGCGTTTTCTCGATAAAATCGTGTCATTTACTCGTGAATTTATTGGTGAGGAAAGGTACTTAATCGGGAGTATTGGCCCATGGGCAGCACATGTATCCTGTGAATATACTGGTGACTATGGTCCCCATCCTGAGAATATTGATTACTACGGCTTTTTCAAACCCCAGCTGGAGAACTTCAACCAAAATAGAGATATTGATCTTATTGGTTTTGAAACGATTCCAAATTTTCATGAGTTAAAGGCTATTTTATCCTGGGATGAAGATATTATTTCGAAGCCCTTTTATATTGGGTTGTCGGTGGATGACAATAGTTTGCTACGAGACGGTACCACTTTGGAAGAAATTTCTGTCCATATAAAAGGCCTCGGAAATAAAATTAACAAGAATCTCTTATTAATGGGAGTTAACTGTGTCAGTTTCAATCAATCGGCATTAATTCTTAAAATGTTGCACGAGCATCTACCTGGCATGCCTCTGCTAGTTTACCCAAACAGTGGAGAAATCTACAATCCCAAAGAGAAGACATGGCACCGGCCGACTAATAAGTTGGATGACTGGGAGACCACGGTTAAGAAATTCGTTGATAATGGTGCGCGCATTATTGGCGGTTGTTGTAGAACGTCTCCTAAAGATATCGCCGAAATTGCATCAGCTGTAGATAAATACTCCTAA","protein_sequence":"MKRIPIKELIVEHPGKVLILDGGQGTELENRGININSPVWSAAPFTSESFWEPSSQERKVVEEMYRDFMIAGANILMTITYQANFQSISENTSIKTLAAYKRFLDKIVSFTREFIGEERYLIGSIGPWAAHVSCEYTGDYGPHPENIDYYGFFKPQLENFNQNRDIDLIGFETIPNFHELKAILSWDEDIISKPFYIGLSVDDNSLLRDGTTLEEISVHIKGLGNKINKNLLLMGVNCVSFNQSALILKMLHEHLPGMPLLVYPNSGEIYNPKEKTWHRPTNKLDDWETTVKKFVDNGARIIGGCCRTSPKDIAEIASAVDKYS"},{"created_at":"2011-05-27T03:41:40.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"tRNA (guanine-N(7)-)-methyltransferase","uniprot_id":"Q12009","uniprot_name":"TRMB_YEAST","enzyme":true,"transporter":false,"gene_name":"TRM8","num_residues":286,"molecular_weight":"33391.19922","theoretical_pi":"9.56","general_function":"Involved in tRNA (guanine-N7-)-methyltransferase activity","specific_function":"Methyltransferase that catalyzes the formation of N(7)- methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity","reactions":[{"id":2740,"direction":"\u003e","locations":"Nucleus","altext":"S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N(7)-methylguanine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus","genbank_gene_id":"X99000","genbank_protein_id":"1429356","gene_card_id":"TRM8","chromosome_location":"chromosome 4","locus":"YDL201W","synonyms":["Transfer RNA methyltransferase 8","tRNA(m7G46)-methyltransferase"],"enzyme_classes":["2.1.1.33"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" RNA methyltransferase activity"},{"category":"Function","description":" tRNA methyltransferase activity"},{"category":"Function","description":" tRNA (guanine) methyltransferase activity"},{"category":"Function","description":" tRNA (guanine-N7-)-methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA processing"},{"category":"Process","description":" tRNA modification"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"}],"pfams":[{"name":"Methyltransf_4","identifier":"PF02390"}],"pathways":[],"gene_sequence":"ATGAAAGCCAAGCCACTAAGCCAAGATCCAGGCTCCAAGCGTTACGCATACCGTATAAATAAGGAAGAAAATCGTAAGGAGTTGAAGCATGTAAAGATCAATGAAAGTTCTTTGGTGCAAGAAGGCCAAAAGATCGACTTGCCAAAGAAGAGATATTATCGTCAAAGGGCGCATTCCAACCCATTTTCAGATCACCAGTTAGAGTACCCAGTATCTCCCCAGGATATGGATTGGTCCAAATTGTACCCTTACTACAAAAACGCGGAAAATGGACAAATGACAAAGAAGGTGACGATTGCTGATATTGGCTGTGGATTCGGTGGGTTGATGATAGATTTATCACCAGCCTTCCCTGAAGATCTTATCTTAGGGATGGAAATTCGTGTGCAGGTTACAAATTACGTGGAGGATAGAATTATTGCCTTAAGGAACAATACAGCTTCAAAACATGGATTTCAAAACATTAATGTCTTGAGAGGTAACGCTATGAAATTCTTGCCCAACTTTTTTGAAAAGGGCCAGCTTTCTAAAATGTTTTTTTGTTTCCCCGATCCTCATTTCAAACAAAGAAAGCATAAGGCAAGAATTATCACTAACACCTTGCTGAGTGAGTACGCATATGTTTTGAAAGAGGGCGGTGTCGTGTACACAATTACAGACGTCAAAGACCTGCATGAGTGGATGGTAAAACATTTAGAAGAGCATCCTTTATTTGAACGGTTGAGCAAAGAATGGGAAGAAAACGATGAATGTGTGAAAATAATGAGAAATGCCACAGAAGAAGGTAAAAAAGTGGAAAGAAAGAAGGGTGACAAGTTCGTCGCTTGTTTCACAAGATTACCAACGCCAGCCATATTGTAA","protein_sequence":"MKAKPLSQDPGSKRYAYRINKEENRKELKHVKINESSLVQEGQKIDLPKKRYYRQRAHSNPFSDHQLEYPVSPQDMDWSKLYPYYKNAENGQMTKKVTIADIGCGFGGLMIDLSPAFPEDLILGMEIRVQVTNYVEDRIIALRNNTASKHGFQNINVLRGNAMKFLPNFFEKGQLSKMFFCFPDPHFKQRKHKARIITNTLLSEYAYVLKEGGVVYTITDVKDLHEWMVKHLEEHPLFERLSKEWEENDECVKIMRNATEEGKKVERKKGDKFVACFTRLPTPAIL"},{"created_at":"2011-05-27T03:42:09.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Homocysteine S-methyltransferase 2","uniprot_id":"Q08985","uniprot_name":"SAM4_YEAST","enzyme":true,"transporter":false,"gene_name":"SAM4","num_residues":325,"molecular_weight":"36668.19922","theoretical_pi":"4.88","general_function":"Involved in homocysteine S-methyltransferase activity","specific_function":"Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S- methylmethionine (SMM) to methionine","reactions":[{"id":1637,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2739,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"S-methyl-L-methionine + L-homocysteine = 2 L-methionine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"Z73629","genbank_protein_id":"1370563","gene_card_id":"SAM4","chromosome_location":"chromosome 16","locus":"YPL273W","synonyms":["S-adenosylmethionine metabolism protein 4","S-methylmethionine:homocysteine methyltransferase 2","SMM:Hcy S-methyltransferase 2"],"enzyme_classes":["2.1.1.10"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" S-methyltransferase activity"},{"category":"Function","description":" homocysteine S-methyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"S-methyl_trans","identifier":"PF02574"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"}],"gene_sequence":"ATGGCACGTCTTCCTCTAAAGCAGTTCTTAGCGGATAACCCCAAAAAAGTTCTTGTTCTTGACGGTGGTCAAGGAACAGAACTGGAAAACAGAGGTATCAAAGTTGCAAATCCCGTGTGGTCTACTATTCCATTTATTAGCGAATCATTTTGGTCTGATGAGTCATCTGCTAACAGAAAAATTGTCAAAGAAATGTTCAACGATTTCTTGAATGCTGGCGCAGAAATATTGATGACTACAACATACCAAACGAGTTATAAATCAGTTTCTGAAAACACCCCAATCAGAACTTTATCCGAGTACAATAACCTTTTAAACAGGATTGTCGATTTTTCTCGTAATTGTATTGGCGAAGACAAATATTTGATTGGCTGTATTGGCCCATGGGGTGCTCATATTTGTCGTGAGTTTACAGGCGACTATGGTGCTGAGCCAGAAAATATTGATTTCTACCAATACTTCAAGCCTCAGTTGGAGAATTTCAATAAAAATGACAAATTGGATTTGATTGGGTTTGAAACCATTCCTAACATCCATGAACTGAAAGCTATCTTATCTTGGGATGAGAGTATCCTGTCTAGACCCTTCTATATCGGGTTGTCTGTGCATGAGCACGGTGTCTTGAGAGACGGCACTACCATGGAAGAAATCGCACAAGTTATTAAGGACTTGGGCGACAAAATAAATCCTAACTTCTCGTTCTTAGGAATCAACTGCGTCAGCTTCAACCAATCACCCGACATTCTTGAGTCTCTACATCAAGCACTACCAAATATGGCCTTGCTTGCTTATCCAAACAGTGGTGAAGTTTATGATACTGAAAAGAAGATATGGTTGCCAAATAGCGATAAGCTGAACAGTTGGGATACGGTTGTTAAACAGTACATTAGCAGCGGTGCCCGTATCATTGGTGGTTGTTGCAGAACAAGTCCAAAAGACATCCAAGAGATTTCTGCAGCCGTCAAGAAATACACGTAA","protein_sequence":"MARLPLKQFLADNPKKVLVLDGGQGTELENRGIKVANPVWSTIPFISESFWSDESSANRKIVKEMFNDFLNAGAEILMTTTYQTSYKSVSENTPIRTLSEYNNLLNRIVDFSRNCIGEDKYLIGCIGPWGAHICREFTGDYGAEPENIDFYQYFKPQLENFNKNDKLDLIGFETIPNIHELKAILSWDESILSRPFYIGLSVHEHGVLRDGTTMEEIAQVIKDLGDKINPNFSFLGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNSDKLNSWDTVVKQYISSGARIIGGCCRTSPKDIQEISAAVKKYT"},{"created_at":"2011-05-27T03:42:34.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Putative nicotinamide N-methyltransferase","uniprot_id":"Q05874","uniprot_name":"NNT1_YEAST","enzyme":true,"transporter":false,"gene_name":"NNT1","num_residues":261,"molecular_weight":"29632.30078","theoretical_pi":"4.78","general_function":"Involved in nicotinamide N-methyltransferase activity","specific_function":"Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination","reactions":[{"id":1776,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2741,"direction":"\u003e","locations":"Cytoplasm","altext":"S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY693038","genbank_protein_id":"51013527","gene_card_id":"NNT1","chromosome_location":"chromosome 12","locus":"YLR285W","synonyms":[],"enzyme_classes":["2.1.1.1"],"go_classes":[],"pfams":[{"name":"Methyltransf_16","identifier":"PF10294"}],"pathways":[{"name":"Nicotinate and nicotinamide 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24-methylene-5-alpha-cholest-8-en-3-beta-ol.","export":false,"pw_reaction_id":null,"source":null},{"id":14409,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006924","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X74249","genbank_protein_id":"396515","gene_card_id":"ERG6","chromosome_location":"chromosome 13","locus":"YML008C","synonyms":["Delta(24)-sterol C-methyltransferase"],"enzyme_classes":["2.1.1.41"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" steroid biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" lipid metabolic process"},{"category":"Process","description":" steroid metabolic process"}],"pfams":[{"name":"Methyltransf_11","identifier":"PF08241"},{"name":"Sterol_MT_C","identifier":"PF08498"}],"pathways":[{"name":"Steroid biosynthesis","kegg_map_id":"00100"},{"name":"Cholesterol biosynthesis and metabolism CE(10:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(12:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(14:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(16:0)","kegg_map_id":null},{"name":"Cholesterol biosynthesis and metabolism CE(18:0)","kegg_map_id":null}],"gene_sequence":"ATGAGTGAAACAGAATTGAGAAAAAGACAGGCCCAATTCACTAGGGAGTTACATGGTGATGATATTGGTAAAAAGACAGGTTTGAGTGCATTGATGTCGAAGAACAACTCTGCCCAAAAGGAAGCCGTTCAGAAGTACTTGAGAAATTGGGATGGTAGAACCGATAAAGATGCCGAAGAACGTCGTCTTGAGGATTATAATGAAGCCACACATTCCTACTATAACGTCGTTACAGATTTCTATGAATATGGTTGGGGTTCCTCTTTCCATTTCAGCAGATTTTATAAAGGTGAGAGTTTCGCTGCCTCGATAGCAAGACATGAACATTATTTAGCTTACAAGGCTGGTATTCAAAGAGGCGATTTAGTTCTCGACGTTGGTTGTGGTGTTGGGGGCCCAGCAAGAGAGATTGCAAGATTTACCGGTTGTAACGTCATCGGTCTAAACAATAACGATTACCAAATTGCCAAGGCAAAATATTACGCTAAAAAATACAATTTGAGTGACCAAATGGACTTTGTAAAGGGTGATTTCATGAAAATGGATTTCGAAGAAAACACTTTCGACAAAGTTTATGCAATTGAGGCCACATGTCACGCTCCAAAATTAGAAGGTGTATACAGCGAAATCTACAAGGTTTTGAAACCGGGTGGTACCTTTGCTGTTTACGAATGGGTAATGACTGATAAATATGACGAAAACAATCCTGAACATAGAAAGATCGCTTATGAAATTGAACTAGGTGATGGTATCCCAAAGATGTTCCATGTCGACGTGGCTAGGAAAGCATTGAAGAACTGTGGTTTCGAAGTCCTCGTTAGCGAAGACCTGGCGGACAATGATGATGAAATCCCTTGGTATTACCCATTAACTGGTGAGTGGAAGTACGTTCAAAACTTAGCTAATTTGGCCACATTTTTCAGAACTTCTTACTTGGGTAGACAATTTACTACAGCAATGGTTACTGTAATGGAAAAATTAGGTCTAGCCCCAGAAGGTTCCAAGGAAGTTACTGCTGCTCTAGAAAATGCTGCGGTTGGTTTAGTTGCCGGTGGTAAGTCCAAGTTATTCACTCCAATGATGCTTTTCGTCGCTAGGAAGCCAGAAAACGCCGAAACCCCCTCCCAAACTTCCCAAGAAGCAACTCAATAA","protein_sequence":"MSETELRKRQAQFTRELHGDDIGKKTGLSALMSKNNSAQKEAVQKYLRNWDGRTDKDAEERRLEDYNEATHSYYNVVTDFYEYGWGSSFHFSRFYKGESFAASIARHEHYLAYKAGIQRGDLVLDVGCGVGGPAREIARFTGCNVIGLNNNDYQIAKAKYYAKKYNLSDQMDFVKGDFMKMDFEENTFDKVYAIEATCHAPKLEGVYSEIYKVLKPGGTFAVYEWVMTDKYDENNPEHRKIAYEIELGDGIPKMFHVDVARKALKNCGFEVLVSEDLADNDDEIPWYYPLTGEWKYVQNLANLATFFRTSYLGRQFTTAMVTVMEKLGLAPEGSKEVTAALENAAVGLVAGGKSKLFTPMMLFVARKPENAETPSQTSQEATQ"},{"created_at":"2011-05-27T05:23:00.000Z","updated_at":"2011-05-27T15:01:24.000Z","name":"S-adenosylmethionine permease SAM3","uniprot_id":"Q08986","uniprot_name":"SAM3_YEAST","enzyme":false,"transporter":true,"gene_name":"SAM3","num_residues":587,"molecular_weight":"64353.0","theoretical_pi":"7.88","general_function":"Involved in transport","specific_function":"High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source","reactions":[],"signal_regions":"None","transmembrane_regions":"81-103;110-129;163-183;187-207;220-240;267-287;303-323;361-381;407-427;432-452;476-496;510-530","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein. Endoplasmic reticulum","genbank_gene_id":"Z73630","genbank_protein_id":"1370565","gene_card_id":"SAM3","chromosome_location":"chromosome 16","locus":"YPL274W","synonyms":["S-adenosylmethionine metabolism protein 3"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGGATATACTCAAGAGGGGAAATGAATCGGACAAGTTTACGAAAATAGAGACAGAATCTACTACGATACCAAATGACTCGGATAGATCTGGTTCACTGATCAGAAGAATGAAGGATTCCTTCAAGCAAAGTAACCTGCATGTCATTCCAGAAGACCTTGAAAACAGCGAACAGACAGAGCAGGAAAAAATCCAATGGAAACTAGCTTCTCAGCCCTATCAAAAAGTCTTGAGCCAAAGGCACTTGACCATGATTGCCATAGGTGGTACTTTGGGGACGGGACTGTTCATTGGTTTAGGTTATTCTTTGGCATCTGGGCCAGCCGCTTTGCTAATCGGTTTTTTGTTAGTTGGTACTTCAATGTTCTGTGTCGTTCAGAGTGCCGCAGAGCTTTCCTGCCAATTCCCGGTTTCTGGCTCATATGCCACACATGTCAGTAGGTTCATAGATGAATCGGTTGGCTTTACTGTGGCTACAAACTATGCTTTGGCTTGGCTGATTTCTTTTCCAAGCGAATTAATTGGTTGTGCACTTACTATTTCATACTGGAACCAAACGGTTAATCCGGCTGTTTGGGTGGCCATTTTTTATGTTTTCATTATGGTACTGAACTTGTTTGGTGTGAGAGGCTTTGCCGAGACTGAGTTTGCTCTGTCAATCATTAAGGTTATTGCTATATTTATTTTCATCATTATTGGTATCGTCCTTATTGCCGGAGGGGGGCCTAACTCTACTGGTTATATTGGCGCCAAATACTGGCACGACCCAGGTGCCTTCGCAAAACCTGTCTTCAAGAATTTGTGTAACACATTCGTTTCTGCTGCTTTTTCCTTTGGTGGTAGTGAGTTAGTGCTGTTAACTAGTACAGAATCTAAAAATATTTCAGCTATATCACGTGCTGCCAAAGGTACGTTCTGGAGAATCGCGATTTTTTACATTACTACCGTTGTCATTATTGGATGTCTCGTACCTTATAACGACCCCAGACTGCTCAGTGGTTCGAACAGTGAGGATGTATCTGCCTCTCCCTTTGTTATTGCTTTGAGTAATACAGGATCAATGGGTGCAAAAGTTTCCAACTTTATGAATGTCGTTATCCTTGTTGCGGTTGTGTCAGTTTGCAATTCTTGCGTTTATGCTTCTTCAAGACTAATTCAAGCTTTAGGTGCATCTGGCCAACTTCCTTCGGTATGTTCCTACATGGACAGAAAGGGTAGGCCTTTGGTTGGCATTGGGATTAGTGGTGCATTTGGTCTTTTAGGTTTTCTTGTGGCCTCGAAAAAGGAGGACGAGGTCTTCACTTGGCTTTTCGCCCTTTGTTCCATTTCATCATTCTTCACCTGGTTCTGTATTTGTATGTCACAAATTAGATTTAGGATGGCTTTGAAAGCTCAAGGAAGATCCAATGACGAAATAGCTTACAAATCCATACTGGGTGTTTATGGTGGAATTTTGGGGTGTGTGCTAAATGCATTGCTAATTGCGGGTGAAATATACGTATCGGCCGCCCCGGTCGGTAGCCCTAGCTCCGCTGAAGCCTTCTTTGAATACTGTTTAAGTATTCCAATCATGATTGTTGTTTATTTTGCACATAGGTTTTATCGAAGAGATTGGAAACACTTCTACATCAAGAGGAGTGAGATCGATCTGGATACTGGGTGTTCCGTGGAGAATCTAGAGCTTTTCAAAGCACAAAAAGAAGCTGAGGAACAACTCATTGCTTCTAAGCCATTCTATTACAAAATCTACAGATTTTGGTGTTAG","protein_sequence":"MDILKRGNESDKFTKIETESTTIPNDSDRSGSLIRRMKDSFKQSNLHVIPEDLENSEQTEQEKIQWKLASQPYQKVLSQRHLTMIAIGGTLGTGLFIGLGYSLASGPAALLIGFLLVGTSMFCVVQSAAELSCQFPVSGSYATHVSRFIDESVGFTVATNYALAWLISFPSELIGCALTISYWNQTVNPAVWVAIFYVFIMVLNLFGVRGFAETEFALSIIKVIAIFIFIIIGIVLIAGGGPNSTGYIGAKYWHDPGAFAKPVFKNLCNTFVSAAFSFGGSELVLLTSTESKNISAISRAAKGTFWRIAIFYITTVVIIGCLVPYNDPRLLSGSNSEDVSASPFVIALSNTGSMGAKVSNFMNVVILVAVVSVCNSCVYASSRLIQALGASGQLPSVCSYMDRKGRPLVGIGISGAFGLLGFLVASKKEDEVFTWLFALCSISSFFTWFCICMSQIRFRMALKAQGRSNDEIAYKSILGVYGGILGCVLNALLIAGEIYVSAAPVGSPSSAEAFFEYCLSIPIMIVVYFAHRFYRRDWKHFYIKRSEIDLDTGCSVENLELFKAQKEAEEQLIASKPFYYKIYRFWC"},{"created_at":"2011-05-27T08:42:47.000Z","updated_at":"2011-05-27T15:01:29.000Z","name":"Putative mitochondrial carrier protein PET8","uniprot_id":"P38921","uniprot_name":"PET8_YEAST","enzyme":false,"transporter":true,"gene_name":"PET8","num_residues":284,"molecular_weight":"31026.59961","theoretical_pi":"10.09","general_function":"Involved in binding","specific_function":null,"reactions":[],"signal_regions":"None","transmembrane_regions":"5-25;50-70;98-118;153-169;194-214;252-272","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":"U02536","genbank_protein_id":"495307","gene_card_id":"PET8","chromosome_location":"chromosome 14","locus":"YNL003C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" binding"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[],"gene_sequence":"ATGAATACTTTTTTTCTTTCCTTGCTAAGTGGCGCCGCTGCTGGTACCTCTACGGATTTGGTTTTTTTCCCTATAGACACAATTAAAACCAGGCTTCAAGCTAAGGGTGGATTCTTTGCTAATGGAGGATACAAAGGCATATATCGTGGTTTGGGAAGCGCTGTTGTAGCATCGGCGCCAGGTGCTTCACTTTTCTTTATTAGTTATGATTATATGAAAGTAAAATCAAGGCCATATATCAGCAAACTTTACTCACAGGGATCTGAGCAATTGATTGATACGACAACGCACATGCTTTCCTCTTCCATTGGTGAAATTTGTGCTTGTCTTGTTCGAGTTCCCGCAGAAGTCGTTAAGCAAAGGACGCAAGTTCACTCTACCAATTCTTCCTGGCAGACTTTACAGTCAATTCTACGAAATGACAATAAGGAAGGTTTAAGGAAAAATCTTTATAGAGGGTGGTCTACCACCATTATGAGAGAAATACCGTTTACTTGTATACAGTTTCCTTTATACGAGTATCTAAAAAAGACTTGGGCAAAAGCCAATGGCCAAAGTCAAGTGGAGCCATGGAAAGGGGCTATCTGCGGTTCTATTGCGGGTGGGATCGCAGCAGCTACAACGACACCATTAGATTTCTTGAAAACCAGATTAATGCTCAACAAAACAACCGCCTCACTTGGAAGCGTTATTATTAGGATTTACAGAGAGGAAGGTCCTGCTGTATTTTTCAGTGGAGTGGGGCCCCGGACAATGTGGATCAGTGCAGGTGGTGCTATCTTCCTAGGCATGTATGAAACTGTTCATTCGTTATTATCGAAAAGTTTCCCAACGGCTGGAGAAATGAGAGCGTAA","protein_sequence":"MNTFFLSLLSGAAAGTSTDLVFFPIDTIKTRLQAKGGFFANGGYKGIYRGLGSAVVASAPGASLFFISYDYMKVKSRPYISKLYSQGSEQLIDTTTHMLSSSIGEICACLVRVPAEVVKQRTQVHSTNSSWQTLQSILRNDNKEGLRKNLYRGWSTTIMREIPFTCIQFPLYEYLKKTWAKANGQSQVEPWKGAICGSIAGGIAAATTTPLDFLKTRLMLNKTTASLGSVIIRIYREEGPAVFFSGVGPRTMWISAGGAIFLGMYETVHSLLSKSFPTAGEMRA"},{"created_at":"2011-05-27T17:52:16.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Mitochondrial tRNA-specific 2-thiouridylase 1","uniprot_id":"Q12093","uniprot_name":"MTU1_YEAST","enzyme":true,"transporter":false,"gene_name":"SLM3","num_residues":417,"molecular_weight":"47048.80078","theoretical_pi":"8.69","general_function":"Translation, ribosomal structure and biogenesis","specific_function":"Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2- thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base","reactions":[{"id":2836,"direction":"\u003e","locations":"Mitochondrion","altext":"S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridylate = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY624369","genbank_protein_id":"48478823","gene_card_id":"SLM3","chromosome_location":"chromosome 4","locus":"YDL033C","synonyms":["Mitochondrial translation optimization protein 2","Synthetic lethal with MSS4 3"],"enzyme_classes":["2.8.1.-","2.1.1.61"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" ncRNA metabolic process"},{"category":"Process","description":" tRNA metabolic process"},{"category":"Process","description":" tRNA processing"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"}],"pfams":[{"name":"tRNA_Me_trans","identifier":"PF03054"}],"pathways":[],"gene_sequence":"ATGCTGGCAAGATATTTAAATTTAATAGGACGGAGGAGTGCTTCACCGTACAGACCACAGCGGCTACCGGCAAAGTTTGACAACGTGATAGTGGCAATGTCATCTGGGGTAGATTCCTCTGTGGCGGCAGCACTATTTGCCGGAGAATTTCCAAATACCCGAGGAGTATATATGCAGAACTGGTCTGAATCACAATCTTTGGACGACCCTGGCAAGGAGCCATGCTACGAGAGGGATTGGAGAGATGTGAACCGTGTCGCTAAGCATTTGAACATCCGAGTTGACAAAGTTAATTTTGAGCAAGATTATTGGATAGATGTATTTGAACCAATGTTGAGAGGCTACAGTGAAGGGTCGACACCCAATCCAGATATCGGTTGCAACAAGTTCGTCAAGTTCGGCAAGCTGAGAGAGTGGCTGGATGAGAAGTATGGGACGGGTAACTATTGGCTTGTTACTGGTCATTACGCCCGAGTTATGCAGGAAATGAATGGAAAAGGATTATTCCATTTACTGAGAAGCATTTATAGGCCCAAGGATCAAAGCTATTACCTTTCACAAATCAACTCCACTGTTTTGTCATCTTTGTTGCTACCCATTGGCCATCTAACGAAACCAGAAGTACGAGATTTAGCGAAGTATGCAGGCCTCCCGACTGCAGAAAAGCCTGATTCACAGGGCATATGCTTCGTCAACAATTCCCAGCATGGGAAGTTCAAGAATTTTTTAAAGCACTACCTACCCAGTTCACCGGGTGATATCATTACCGTTGACCCACAATCCGGTGCCAAAACGACATGGGGCAGACACGATGGATTGTGGTCTTACACAATTGGACAGAAAGTGGGCATATCCATGCCACAAGCTGACCCTAATTACCAAGGGACCTGGTTTGTCAGTGAAAAACTAAGGGATACCAACGAAATCTTGATAGTCAGAGGAAGAGATAATCCGGCGCTATACAGTGACACTATGCGAATCGAAAACTTTTCGTCTTTGGGCCCCAGGGAGGACACTATAAACGCTTTCCAAAATACTGGTGCCTTGACATTACAATTCCGGTCCCTGCAGGTCCCAGTCCAAATTAAATCGTGCAAACTGAATCGCTCTGCCGACAACCTCGACATAACAATACACTTAGCCTCAAAACAACGTGCCATAACTCCTGGGCAATCGTGCTGTCTATATATCGACGATAGAGTCCTTGGGAGTGGGCCCATTTCCCATGTTAATAATAATGACACCCATGCATAG","protein_sequence":"MLARYLNLIGRRSASPYRPQRLPAKFDNVIVAMSSGVDSSVAAALFAGEFPNTRGVYMQNWSESQSLDDPGKEPCYERDWRDVNRVAKHLNIRVDKVNFEQDYWIDVFEPMLRGYSEGSTPNPDIGCNKFVKFGKLREWLDEKYGTGNYWLVTGHYARVMQEMNGKGLFHLLRSIYRPKDQSYYLSQINSTVLSSLLLPIGHLTKPEVRDLAKYAGLPTAEKPDSQGICFVNNSQHGKFKNFLKHYLPSSPGDIITVDPQSGAKTTWGRHDGLWSYTIGQKVGISMPQADPNYQGTWFVSEKLRDTNEILIVRGRDNPALYSDTMRIENFSSLGPREDTINAFQNTGALTLQFRSLQVPVQIKSCKLNRSADNLDITIHLASKQRAITPGQSCCLYIDDRVLGSGPISHVNNNDTHA"},{"created_at":"2011-05-27T17:53:23.000Z","updated_at":"2011-05-29T05:06:52.000Z","name":"S-adenosylmethionine synthase 2","uniprot_id":"P19358","uniprot_name":"METK2_YEAST","enzyme":true,"transporter":false,"gene_name":"SAM2","num_residues":384,"molecular_weight":"42255.5","theoretical_pi":"4.98","general_function":"Coenzyme transport and metabolism","specific_function":"Catalyzes the formation of S-adenosylmethionine from methionine and ATP","reactions":[{"id":1728,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2580,"direction":"\u003e","locations":"","altext":"ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine.","export":false,"pw_reaction_id":null,"source":null},{"id":3761,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006285","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M23368","genbank_protein_id":"295659","gene_card_id":"SAM2","chromosome_location":"chromosome 4","locus":"YDR502C","synonyms":["AdoMet synthase 2","Methionine adenosyltransferase 2","MAT 2"],"enzyme_classes":["2.5.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" methionine adenosyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Process","description":" one-carbon metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"S-AdoMet_synt_C","identifier":"PF02773"},{"name":"S-AdoMet_synt_M","identifier":"PF02772"},{"name":"S-AdoMet_synt_N","identifier":"PF00438"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGTCCAAGAGCAAAACTTTCTTATTTACCTCTGAATCCGTCGGTGAAGGTCACCCAGACAAGATTTGTGACCAAGTTTCTGATGCTATTTTGGACGCTTGTTTAGAACAAGATCCATTCTCCAAGGTTGCCTGTGAAACAGCTGCCAAAACTGGTATGATTATGGTTTTCGGTGAAATTACCACCAAAGCTAGACTTGACTACCAACAAATAGTAAGAGATACCATCAAGAAGATTGGTTATGACGATTCTGCCAAGGGTTTCGACTACAAGACATGTAATGTTTTAGTAGCTATCGAACAACAATCTCCAGATATCGCTCAAGGTCTGCACTATGAAAAGAGCTTAGAAGACTTAGGTGCTGGTGACCAAGGTATAATGTTTGGTTACGCTACAGACGAAACTCCAGAAGGGTTACCATTGACCATTCTTTTGGCTCACAAATTGAACATGGCTATGGCAGATGCTAGAAGAGATGGTTCTCTCCCATGGTTGAGACCAGACACAAAGACTCAAGTCACTGTCGAATACGAAGACGACAATGGTAGATGGGTTCCAAAGAGGATAGATACCGTTGTTATTTCTGCTCAACATGCTGATGAAATTTCCACCGCTGACTTGAGAACTCAACTTCAAAAAGATATTGTTGAAAAGGTCATACCAAAGGATATGTTAGACGAAAATACCAAATATTTCATCCAACCATCCGGTAGATTCGTCATCGGTGGTCCTCAAGGTGACGCTGGTTTGACCGGTAGAAAGATTATTGTCGACGCTTACGGTGGTGCCTCATCCGTCGGTGGTGGTGCCTTCTCCGGTAAGGACTATTCCAAGGTCGATCGTTCCGCTGCTTACGCTGCTAGATGGGTTGCCAAGTCTCTAGTTGCCGCTGGTTTGTGTAAGAGAGTCCAAGTCCAATTTTCATATGCTATTGGTATTGCTGAACCATTGTCTTTACATGTGGACACCTATGGTACAGCTACAAAATCAGATGACGAAATCATTGAAATTATTAAGAAGAACTTCGACTTGAGACCAGGTGTGTTAGTAAAGGAATTAGATTTGGCTAGACCAATTTACTTACCAACCGCTTCTTATGGTCACTTCACTAATCAAGAGTACTCATGGGAAAAACCAAAGAAATTGGAATTTTAA","protein_sequence":"MSKSKTFLFTSESVGEGHPDKICDQVSDAILDACLEQDPFSKVACETAAKTGMIMVFGEITTKARLDYQQIVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGLHYEKSLEDLGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLPWLRPDTKTQVTVEYEDDNGRWVPKRIDTVVISAQHADEISTADLRTQLQKDIVEKVIPKDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDDEIIEIIKKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYSWEKPKKLEF"},{"created_at":"2011-05-29T04:49:56.000Z","updated_at":"2011-05-29T05:06:53.000Z","name":"tRNA (uracil-5-)-methyltransferase","uniprot_id":"P33753","uniprot_name":"TRM2_YEAST","enzyme":true,"transporter":false,"gene_name":"TRM2","num_residues":639,"molecular_weight":"72851.79688","theoretical_pi":"9.14","general_function":"Involved in RNA methyltransferase activity","specific_function":"Catalyzes the formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNA. May also have a role in tRNA stabilization or maturation","reactions":[{"id":2849,"direction":"\u003e","locations":null,"altext":"S-adenosyl-L-methionine + tRNA containing uridine at position 54 = S-adenosyl-L-homocysteine + tRNA containing ribothymidine at position 54.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"TRM2","chromosome_location":"chromosome 11","locus":"YKR056W","synonyms":["Transfer RNA methyltransferase 2","tRNA(M-5-U54)-methyltransferase"],"enzyme_classes":["2.1.1.35"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" RNA methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" RNA processing"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" RNA metabolic process"}],"pfams":[{"name":"TRAM","identifier":"PF01938"},{"name":"tRNA_U5-meth_tr","identifier":"PF05958"}],"pathways":[],"gene_sequence":"ATGTACGAACAGTTTGAATTTTCTTTTTTTTTCTTCGAAAATTCAGACAATAAGGTTAAATATAAAGCTCATCTCATCTCATCGATAAAACGCTGGAGTATTATCACATGCATGCGTTGCTTTTGGACCGTACAGAAGTCTATATTTAAAGCTAGGTTTTTCGCTTGCAGAAACTTTGTCAAGAAGCATAATTATAAACTAATCAGCACCATGACTGGAAGTACTGAAATGGTACCACCAACAATGAAACATACCGTTGACAACAAAAGGCTTTCGTCTCCTTTGACAGATTCTGGTAACCGCCGGACTAAGAAGCCAAAGTTGAGAAAGTACAAGGCCAAAAAGGTTGAAACAACTTCTCCGATGGGTGTCCTAGAATTTGAAGTGAACGATTTGTTAAAATCTCAAAATTTGTCCAGGGAGCAGGTTCTGAACGATGTTACTTCAATTCTAAATGATAAGTCCTCAACAGATGGACCTATCGTCTTACAATATCACCGAGAGGTAAAAAATGTCAAGGTCTTAGAAATTACTTCCAATGGCAACGGGTTGGCTTTGATCGATAATCCTGTTGAAACAGAAAAGAAGCAAGTTGTTATCATACCGTTTGGCCTGCCCGGTGATGTAGTTAATATCAAAGTCTTTAAGACCCACCCTTACTATGTCGAGAGTGATTTATTAGACGTAGTGGAAAAATCTCCAATGAGAAGAGATGATTTAATTAGGGATAAATATTTCGGGAAATCTTCAGGAAGTCAATTAGAGTTCTTAACTTACGATGACCAACTAGAATTGAAAAGAAAAACAATTATGAATGCCTACAAGTTCTTCGCACCAAGGTTAGTTGCTGAAAAACTTTTACCCCCATTTGACACCACCGTAGCTTCCCCTTTACAATTTGGCTACAGGACCAAAATTACGCCTCATTTCGATATGCCAAAAAGAAAACAAAAGGAACTATCAGTAAGGCCTCCTTTAGGATTTGGTCAAAAGGGTAGACCTCAATGGAGAAAAGATACTTTGGATATCGGCGGACATGGTTCGATATTAGATATCGATGAATGTGTGCTTGCAACTGAAGTTCTCAACAAAGGATTGACTAATGAAAGAAGAAAGTTTGAGCAAGAGTTTAAAAACTACAAAAAAGGCGCGACTATTTTACTGAGAGAGAATACCACTATTTTAGACCCTTCCAAACCAACTTTAGAACAGTTAACCGAAGAAGCCTCTAGGGATGAAAATGGTGATATAAGTTATGTCGAAGTCGAAGACAAAAAGAACAATGTCAGGCTGGCTAAAACTTGCGTTACCAATCCTAGACAAATTGTCACTGAATATGTTGATGGATATACTTTTAATTTTAGTGCGGGTGAGTTTTTTCAAAATAATAACTCTATCCTGCCAATAGTGACCAAGTATGTCCGTGATAACTTGCAAGCTCCCGCTAAAGGTGATGATAATAAAACAAAGTTTCTAGTAGATGCTTATTGTGGATCAGGTCTTTTCAGTATATGCAGCTCCAAGGGCGTAGATAAAGTGATTGGTGTAGAAATTTCCGCTGACAGTGTCTCTTTTGCAGAAAAAAATGCAAAGGCAAATGGTGTTGAAAACTGTAGATTCATCGTTGGAAAGGCTGAGAAACTCTTTGAGTCTATTGATACTCCAAGTGAAAACACTTCCGTTATCTTGGATCCACCACGCAAGGGCTGTGACGAATTATTCCTAAAGCAATTAGCCGCATATAATCCAGCCAAGATTATTTACATATCGTGTAATGTCCATTCCCAGGCACGTGATGTCGAGTACTTCCTCAAAGAAACAGAAAACGGTTCCGCCCACCAGATTGAAAGCATAAGAGGATTTGATTTCTTTCCACAAACGCACCACGTTGAGAGTGTGTGTATAATGAAGAGAATCTAA","protein_sequence":"MYEQFEFSFFFFENSDNKVKYKAHLISSIKRWSIITCMRCFWTVQKSIFKARFFACRNFVKKHNYKLISTMTGSTEMVPPTMKHTVDNKRLSSPLTDSGNRRTKKPKLRKYKAKKVETTSPMGVLEFEVNDLLKSQNLSREQVLNDVTSILNDKSSTDGPIVLQYHREVKNVKVLEITSNGNGLALIDNPVETEKKQVVIIPFGLPGDVVNIKVFKTHPYYVESDLLDVVEKSPMRRDDLIRDKYFGKSSGSQLEFLTYDDQLELKRKTIMNAYKFFAPRLVAEKLLPPFDTTVASPLQFGYRTKITPHFDMPKRKQKELSVRPPLGFGQKGRPQWRKDTLDIGGHGSILDIDECVLATEVLNKGLTNERRKFEQEFKNYKKGATILLRENTTILDPSKPTLEQLTEEASRDENGDISYVEVEDKKNNVRLAKTCVTNPRQIVTEYVDGYTFNFSAGEFFQNNNSILPIVTKYVRDNLQAPAKGDDNKTKFLVDAYCGSGLFSICSSKGVDKVIGVEISADSVSFAEKNAKANGVENCRFIVGKAEKLFESIDTPSENTSVILDPPRKGCDELFLKQLAAYNPAKIIYISCNVHSQARDVEYFLKETENGSAHQIESIRGFDFFPQTHHVESVCIMKRI"},{"created_at":"2011-06-14T19:32:35.000Z","updated_at":"2011-06-14T19:32:35.000Z","name":"Histone-lysine N-methyltransferase, H3 lysine-79 specific","uniprot_id":"Q04089","uniprot_name":"DOT1_YEAST","enzyme":true,"transporter":false,"gene_name":"DOT1","num_residues":582,"molecular_weight":"66200.70313","theoretical_pi":"9.46","general_function":"Involved in histone-lysine N-methyltransferase activity","specific_function":"Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. Can bind to DNA (in vitro)","reactions":[{"id":2855,"direction":"\u003e","locations":"Nucleus (Probable). Chromosome (Probable);Nucleus;Nucleus. Chromosome (Probable)","altext":"S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1U2Z","cellular_location":"Nucleus","genbank_gene_id":"U33007","genbank_protein_id":"927702","gene_card_id":"DOT1","chromosome_location":"chromosome 4","locus":"YDR440W","synonyms":["Disrupter of telomere silencing protein 1","Histone H3-K79 methyltransferase","H3-K79-HMTase","Lysine N-methyltransferase 4"],"enzyme_classes":["2.1.1.43"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" protein methyltransferase activity"},{"category":"Function","description":" protein-lysine N-methyltransferase activity"},{"category":"Function","description":" histone-lysine N-methyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"DOT1","identifier":"PF08123"}],"pathways":[{"name":"Lysine degradation","kegg_map_id":"00310"}],"gene_sequence":"ATGGGCGGTCAAGAAAGTATATCAAATAATAACTCAGACTCATTCATTATGTCGTCCCCCAACTTAGACTCTCAGGAATCTTCAATATCACCTATTGATGAGAAGAAAGGCACCGATATGCAAACCAAGTCGCTTTCAAGCTATTCTAAAGGTACGCTTCTCTCTAAGCAAGTACAAAATTTATTAGAAGAAGCTAATAAATACGATCCAATATATGGGTCATCTTTACCTCGAGGATTTTTAAGAGATAGAAACACCAAGGGTAAGGATAATGGGTTGGTTCCGCTGGTGGAGAAGGTTATACCTCCCATTCACAAGAAAACCAATAATAGAAACACAAGGAAGAAGTCATCTACCACCACGAAGAAGGATGTAAAGAAGCCAAAAGCTGCAAAAGTAAAAGGAAAAAATGGCAGGACTAACCATAAACATACCCCAATTTCAAAGCAAGAAATAGATACTGCACGAGAAAAAAAGCCATTGAAAAAAGGTCGGGCAAACAAGAAGAATGATCGCGATAGTCCTTCATCAACATTTGTTGATTGGAATGGCCCGTGTCTACGGTTACAATATCCATTATTTGACATAGAGTACTTAAGATCACATGAAATATATTCTGGAACTCCTATACAATCCATTAGTTTAAGAACAAATTCTCCACAGCCAACGAGCTTGACATCAGATAACGACACTTCCTCAGTAACGACAGCAAAGTTGCAGAGTATTTTATTTTCAAATTATATGGAAGAGTACAAAGTCGACTTCAAAAGGTCAACAGCCATTTATAATCCAATGAGTGAAATTGGTAAATTAATTGAATACAGCTGCCTGGTCTTTTTACCTTCACCTTATGCTGAACAATTGAAGGAAACTATACTACCGGACCTAAATGCATCATTTGATAACTCTGACACGAAAGGTTTCGTGAATGCTATAAATTTATACAACAAAATGATTCGTGAAATTCCTAGGCAAAGAATAATTGACCATTTAGAAACAATTGATAAAATTCCTCGTTCATTCATTCATGACTTCTTGCATATCGTCTATACCAGGAGTATCCATCCGCAGGCGAATAAATTGAAACATTACAAAGCATTCAGCAATTATGTTTATGGAGAACTTTTGCCCAATTTCCTATCTGATGTATATCAACAATGCCAGTTGAAGAAGGGTGACACTTTCATGGATCTCGGTTCGGGAGTAGGTAATTGCGTAGTACAAGCTGCGTTGGAATGTGGATGTGCATTAAGCTTCGGATGTGAAATCATGGATGATGCTAGCGATTTAACTATACTGCAGTACGAGGAACTAAAGAAGAGGTGTAAGTTATATGGGATGCGTTTGAACAACGTGGAGTTTTCATTGAAGAAAAGCTTTGTGGACAATAACAGGGTCGCTGAACTAATTCCTCAGTGCGATGTTATCCTCGTAAATAATTTTTTATTTGATGAAGATTTGAATAAAAAAGTCGAAAAGATACTACAAACGGCAAAAGTTGGATGTAAGATCATAAGTTTGAAAAGTTTAAGAAGCCTCACTTATCAGATCAACTTCTACAATGTTGAGAACATCTTCAATAGATTAAAGGTGCAAAGGTATGATCTTAAGGAGGATAGTGTTTCATGGACGCATAGTGGCGGAGAGTATTATATATCAACAGTGATGGAGGATGTGGACGAAAGTTTATTCAGCCCTGCTGCAAGAGGTAGGAGGAACAGAGGTACGCCGGTGAAGTATACCAGATGA","protein_sequence":"MGGQESISNNNSDSFIMSSPNLDSQESSISPIDEKKGTDMQTKSLSSYSKGTLLSKQVQNLLEEANKYDPIYGSSLPRGFLRDRNTKGKDNGLVPLVEKVIPPIHKKTNNRNTRKKSSTTTKKDVKKPKAAKVKGKNGRTNHKHTPISKQEIDTAREKKPLKKGRANKKNDRDSPSSTFVDWNGPCLRLQYPLFDIEYLRSHEIYSGTPIQSISLRTNSPQPTSLTSDNDTSSVTTAKLQSILFSNYMEEYKVDFKRSTAIYNPMSEIGKLIEYSCLVFLPSPYAEQLKETILPDLNASFDNSDTKGFVNAINLYNKMIREIPRQRIIDHLETIDKIPRSFIHDFLHIVYTRSIHPQANKLKHYKAFSNYVYGELLPNFLSDVYQQCQLKKGDTFMDLGSGVGNCVVQAALECGCALSFGCEIMDDASDLTILQYEELKKRCKLYGMRLNNVEFSLKKSFVDNNRVAELIPQCDVILVNNFLFDEDLNKKVEKILQTAKVGCKIISLKSLRSLTYQINFYNVENIFNRLKVQRYDLKEDSVSWTHSGGEYYISTVMEDVDESLFSPAARGRRNRGTPVKYTR"},{"created_at":"2011-06-14T19:33:11.000Z","updated_at":"2011-06-14T19:33:11.000Z","name":"Histone-lysine N-methyltransferase, H3 lysine-36 specific","uniprot_id":"P46995","uniprot_name":"SET2_YEAST","enzyme":true,"transporter":false,"gene_name":"SET2","num_residues":733,"molecular_weight":"84538.79688","theoretical_pi":"8.67","general_function":"Involved in histone-lysine N-methyltransferase activity","specific_function":"Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression. The methyltransferase activity requires the recruitment to the RNA polymerase II, which is CTK1 dependent","reactions":[{"id":2855,"direction":"\u003e","locations":"Nucleus (Probable). Chromosome (Probable);Nucleus;Nucleus. Chromosome (Probable)","altext":"S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus. Chromosome (Probable)","genbank_gene_id":"Z49444","genbank_protein_id":"1008361","gene_card_id":"SET2","chromosome_location":"chromosome 10","locus":"YJL168C","synonyms":["Lysine N-methyltransferase 3","SET domain-containing protein 2"],"enzyme_classes":["2.1.1.43"],"go_classes":[{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Component","description":" nucleus"},{"category":"Component","description":" non-membrane-bounded organelle"},{"category":"Component","description":" intracellular non-membrane-bounded organelle"},{"category":"Component","description":" chromosome"},{"category":"Component","description":" organelle"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" protein methyltransferase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" protein-lysine N-methyltransferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" histone-lysine N-methyltransferase activity"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" protein binding"},{"category":"Process","description":" regulation of metabolic process"},{"category":"Process","description":" regulation of macromolecule metabolic process"},{"category":"Process","description":" regulation of gene expression"},{"category":"Process","description":" regulation of transcription"},{"category":"Process","description":" regulation of transcription, DNA-dependent"},{"category":"Process","description":" biological regulation"},{"category":"Process","description":" regulation of biological process"}],"pfams":[{"name":"SET","identifier":"PF00856"},{"name":"SRI","identifier":"PF08236"}],"pathways":[{"name":"Lysine degradation","kegg_map_id":"00310"}],"gene_sequence":"ATGTCGAAGAACCAAAGTGTGAGTGCGTCGGAAGATGAAAAAGAAATACTGAATAACAACGCTGAGGGCCATAAACCTCAAAGGCTTTTTGATCAAGAGCCTGATCTCACAGAGGAAGCATTGACCAAATTTGAAAACTTGGATGACTGTATATATGCGAACAAGAGGATCGGAACATTTAAGAATAATGATTTCATGGAATGTGACTGTTATGAAGAATTCTCAGATGGCGTCAACCATGCCTGTGACGAGGATTCTGACTGTATCAATAGACTTACGTTGATAGAATGTGTCAACGATTTGTGTTCATCTTGTGGTAATGATTGTCAAAATCAGAGATTTCAAAAGAAGCAGTACGCTCCGATAGCCATATTTAAAACAAAGCATAAAGGTTATGGCGTAAGAGCCGAACAGGACATAGAAGCCAACCAGTTCATTTACGAGTACAAAGGTGAGGTGATCGAGGAGATGGAATTTAGAGATAGGTTAATAGACTATGACCAACGTCATTTCAAGCATTTTTATTTTATGATGTTACAGAACGGAGAATTCATTGACGCCACAATAAAGGGTTCGTTGGCCAGATTTTGCAATCACTCTTGCAGCCCCAATGCATATGTTAATAAATGGGTTGTTAAGGATAAGCTACGCATGGGAATATTTGCTCAAAGAAAAATTTTAAAAGGTGAGGAAATCACTTTTGATTATAATGTGGATCGTTATGGTGCTCAAGCTCAGAAATGCTACTGTGAGGAGCCAAATTGTATTGGGTTTCTCGGTGGTAAGACTCAAACAGATGCGGCATCTTTATTGCCCCAGAACATCGCTGATGCCTTGGGAGTGACTGTTTCCATGGAGAAAAAATGGCTAAAGTTAAAGAAATTAAGCGGTGAGCCAATAATAAAGAATGAAAACGAGAACATAAATATTGAATTTCTTCAATCATTGGAAGTCCAACCTATCGACAGCCCAGTGGATGTGACGAAGATCATGAGTGTATTACTACAGCAAGATAATAAGATAATTGCATCCAAACTCTTGAAGAGACTTTTTACTATCGATGATGACTCTCTTCGTCATCAGGCTATCAAACTACACGGTTACACCTGTTTTAGCAAAATGCTTAAATTGTTTATCACGGAACAACCTCAGGTAGATGGAAAAGGAAACGAGACTGAAGAAGATGATATAAAGTTTATAAAGGGAATTTTAGATTTTTTGTTGGAATTACCAAAGACAACTCGAAACGGTATTGAGTCGTCACAAATTGATAATGTAGTAAAAACTCTCCCTGCAAAGTTTCCATTTTTAAAGCCAAACTGCGATGAGTTATTGGAGAAATGGTCGAAATTTGAAACATATAAAAGGATAACGAAGAAAGACATAAACGTCGCAGCCAGCAAAATGATAGATTTGAGAAGGGTGAGATTACCTCCAGGCTGGGAGATCATTCACGAAAACGGTCGCCCATTGTATTATAATGCAGAACAGAAAACGAAACTACACTATCCACCTTCGGGATCATCTAAGGTCTTTAGTTCAAGGTCAAATACACAAGTAAATTCTCCGAGTAGCAGTGGAATACCAAAAACGCCTGGCGCTTTAGACTCTAAGAAACATAAGCTGAGTGACGAAGAATATGAGAGGAAGAAACAAAAAAGACTGGAATACGAAAGAATTGCGCTAGAAAGAGCCAAACAAGAAGAATTGGAAAGCCTGAAGCAAAAGCTAAAGCTTGAGAATGAAAGAAAAAGCGTTTTGGAGGATATTATAGCGGAGTTCAACAAACAGAAGGAGTTACAAAAGGAAGAGTCCAAAAAACTAGTGGAAGCAAAAGAGGCTAAGCGGTTGAAAAGAAAAACGGTCTCCCAGTCCCAAAGACTAGAGCACAACTGGAATAAATTCTTTGCATCTTTTGTACCCAACTTAATAAAAAAAAACCCACAAAGTAAACAATTTGATCATGAAAACATTAAACAATGTGCTAAAGACATCGTGAAAATCCTAACTACAAAGGAACTTAAAAAAGATTCTTCAAGAGCGCCGCCTGATGACTTAACCAAAGGAAAAAGGCATAAAGTTAAAGAATTCATAAATTCATACATGGATAAGATTATCCTCAAGAAGAAGCAAAAAAAGGCGTTGGGATTATCATCAGCATCAACAAGGATGTCTTCTCCTCCACCTTCAACATCATCATAA","protein_sequence":"MSKNQSVSASEDEKEILNNNAEGHKPQRLFDQEPDLTEEALTKFENLDDCIYANKRIGTFKNNDFMECDCYEEFSDGVNHACDEDSDCINRLTLIECVNDLCSSCGNDCQNQRFQKKQYAPIAIFKTKHKGYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQKCYCEEPNCIGFLGGKTQTDAASLLPQNIADALGVTVSMEKKWLKLKKLSGEPIIKNENENINIEFLQSLEVQPIDSPVDVTKIMSVLLQQDNKIIASKLLKRLFTIDDDSLRHQAIKLHGYTCFSKMLKLFITEQPQVDGKGNETEEDDIKFIKGILDFLLELPKTTRNGIESSQIDNVVKTLPAKFPFLKPNCDELLEKWSKFETYKRITKKDINVAASKMIDLRRVRLPPGWEIIHENGRPLYYNAEQKTKLHYPPSGSSKVFSSRSNTQVNSPSSSGIPKTPGALDSKKHKLSDEEYERKKQKRLEYERIALERAKQEELESLKQKLKLENERKSVLEDIIAEFNKQKELQKEESKKLVEAKEAKRLKRKTVSQSQRLEHNWNKFFASFVPNLIKKNPQSKQFDHENIKQCAKDIVKILTTKELKKDSSRAPPDDLTKGKRHKVKEFINSYMDKIILKKKQKKALGLSSASTRMSSPPPSTSS"},{"created_at":"2011-06-14T19:33:47.000Z","updated_at":"2011-06-14T19:33:47.000Z","name":"Histone-lysine N-methyltransferase, H3 lysine-4 specific","uniprot_id":"P38827","uniprot_name":"SET1_YEAST","enzyme":true,"transporter":false,"gene_name":"SET1","num_residues":1080,"molecular_weight":"123911.0","theoretical_pi":"9.36","general_function":"Involved in histone-lysine N-methyltransferase activity","specific_function":"Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation","reactions":[{"id":2855,"direction":"\u003e","locations":"Nucleus (Probable). Chromosome (Probable);Nucleus;Nucleus. Chromosome (Probable)","altext":"S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Nucleus (Probable). Chromosome (Probable)","genbank_gene_id":"U00059","genbank_protein_id":"529127","gene_card_id":"SET1","chromosome_location":"chromosome 8","locus":"YHR119W","synonyms":["COMPASS component SET1","Lysine N-methyltransferase 2","SET domain-containing protein 1"],"enzyme_classes":["2.1.1.43"],"go_classes":[{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Component","description":" chromatin remodeling complex"},{"category":"Component","description":" Set1C/COMPASS complex"},{"category":"Function","description":" protein methyltransferase activity"},{"category":"Function","description":" protein-lysine N-methyltransferase activity"},{"category":"Function","description":" histone-lysine N-methyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" methyltransferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" protein binding"},{"category":"Process","description":" chromosome organization"},{"category":"Process","description":" chromatin organization"},{"category":"Process","description":" chromatin modification"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular component organization at cellular level"},{"category":"Process","description":" organelle organization"}],"pfams":[{"name":"SET","identifier":"PF00856"}],"pathways":[{"name":"Lysine degradation","kegg_map_id":"00310"}],"gene_sequence":"ATGACGACGAAGCCACAAAATAGTAAGCAGGGTTTAGCCGAAGGAGAGATGGATGTGAGTTCACTTTTCAAGAGAACGGAAGTTATTGGGCGAGGGAAATTTGGTGTGGTTTATAAGGGCTATAACGTGAAGACTGGACGAGTGTATGCTATCAAAGTCTTAAATTTAGATTCTGATTCTGACGAGGTGGAGGATGTGCAGCGAGAAATTCAGTTTTTGGCCTCCTTGAAACAGATTTCCAATATCACGCGGTATTATGGGTCGTATTTGAAAGACACAAGCCTTTGGATCATAATGGAACACTGCGCTGGTGGTTCACTGCGTTCGTTGTTAAGGCCAGGCAAAATCGATGAAAAGTACATTGGGGTTATTATGAGAGAACTGCTTGTAGCATTAAAATGCATTCATAAAGATAACGTCATTCATCGAGATATCAAAGCAGCAAACGTTCTGATCACTAACGAAGGTAATGTTAAACTATGCGATTTTGGTGTCGCTGCACAAGTAAACCAAACTTCTTTACGACGTCAAACTATGGCTGGGACCCCCTACTGGATGGCTCCAGAAGTGATCATGGAAGGCGTTTATTACGACACTAAAGTAGATATATGGTCTTTAGGTATTACAACGTACGAGATTGCCACCGGAAATCCGCCATACTGCGATGTGGAGGCCCTAAGGGCAATGCAACTAATCATCAAATCGAAACCACCGAGGCTTGAGGACAGATCATACAGTACATCTTTGAAAGAATTTATTGCGCTTTGTCTTGATGAGGATCCAAAGGAGAGATTGTCAGCAGACGATCTTTTAAAATCAAAATTTATCAGGGCCCACAAGGCGACGCCAACGTCCATTTTGAAAGAACTAATATCACGATATCTACTATTTAGGGACAAGAATAAAAACAAATATAAAATAGAGGGCAGTATACCGGAAAATGAGCCATCAAAACCCAGTGAAGCTCCAAAACCATCACAAAATGGCGGGGGTGATGAAGCACAAAAGTCAATAGCATCAAATGATAATGAAATTAAGAGAGTGAACGAAGGCGATGTGGAAATGAAATGGGATTTTGATTCATTGAGTTCGTCGGATTATATTATTGAAAATAATATCAACCTCGATGCTTTGGCTGAGGACAACAACGAGTGGGCTACTGCCCAACATGACCTGTTCAACTATGCATACCCTGACGAAGATTCTTATTACTTTGACCCTACAAGTCATAATACTAGACCCTTTGTTTATCAAGGGACAACGATAGGAAAGGGCTATCCTGGTACAATAGCTCAAAATTCTACTTTGAATGCACCAGTAACAAATAACTATACGAACTCAAAATACCCTTCCAAAATGGTAGCTGGAACTACAAACACCTCTGGAACACATACGGCCGGTCCAATGACATCATCTAAGAGGCTGGAAAGTAAGGCTCCAAAACAATTACTTGAACTTTTTGAAGACAATGAAATTATTACTGCTGAAAATGATGTCAATACAGAAGCTCCTAAAATAAGCAAATCCATTTCATCTCTAAATGCTGGTAATAGTTCACGAGATGATTTCATTCCCTCAATATCCAACGAGGTCAACGGAAATATCAATAATAATAAAATGCGACCACACCTTCCACCTTTATCCAGTGGGAACAATTATTATAGCCAGAGTACACCTGCTTTGCCGCTACTCCAAACAAAATTTAACAAGACGTCAAAGGGCCCTCCAACAAGTGGATTAACTACTGCTCCAACGTCTATTGAAATAGAAATTCCTGAAGAACTACCGAATAGTGCTCTACCAACGCCTGCGAGCGCAGATCCGGTTTTAATACCAAGCACAAAGGCCAGGTCATCTACAGTGACGGCTGGCACTCCTTCGTCATCTAGCTCAATACAATATAAATCACCTTCAAACGTGCCCAGGCGGTTGACAGTCAGTAACAATAGGCCAGAACATTGCCCAAGCACCATAACAAATCAAAAATTGGGGTCCGCAGTTGCTTCTAATTCCGGAATCAGCTCCACTCCGAACAACAGTAATAACTATAACAACAACACTGATAGTGAGAACTCAAGAGGAAGCAGCGGTAGTAACACTGCAAATAGCACACAAATGGGCATAACCAATCCAGGTAATGTAACAAAGTTATCTACTCATAAGGCTTCTTCACCCTCAAGGCCACTATTTGGAGTTGGAACTTCTCCCAATAGAAAGCCTGCCGGTTCCCCAACCCAAAACATTGGTCATAATTCTACTCACACGAACCTCGCGCCTCCTCCTACGATGAAACCAATGGCCAATAGCAAAGATAACAAGGACATTCTCTTGCAACCTCTGAACAGCATACCTAGTTCTTCTACACTTAACACTATTAGTGGTAATAGCAGCAATAATTTAACCTCATCAAACTACTTTTCCAACGAAAAGGAAGGCTCAAGGGTCAATGGTGACTTTAAACGCAACAACCCAAACTTAAAACTACAAATGCCACTACCTACACCTGTTGTGAGAAATAAACTTCTTGATCCAAATACAGCAACCTCACAGAATAACAATGGCATGCCGGGGAGCGCTGGCATATCCACGAACGAAAATATTAATCAATTTGGATTTAACACAAGCAGTGCGTCCAACATCCCTGTCTCAATGACTCCAATTAGTGAGAAACACATTGATTTTGGGGGCAAGATCAAGAGAAGTCAAAGCATTTCTAACAGGAAGAACTCTTCTGCCTCGGAACACCCATTGAATATTCTTGGCTCATCTGTTTCCGGCAATGTTTCCGGTATCGGTAACAACAATGTTGGCTCTAACAACAACAGCGGCCCTAATAACAGTGTTCCTCTTTCTGCTAATACAGGAAACACTACTATCAAAGCCAATTCTACGACTATCGCAACTTCAAGTTCTGCCGCGGCATCAACGACTGCACCAATTTCACAACAGACTATTCCATCCGGAACACAATTCAATCATATTCTGAGTTCCGCCGCAACAGCTGCAAACTCGGTTAATTCTTTAGGCTTTGGCATGTGTCCTCCTCCACAGAGTTTACAAATGGAAATGTTCTTGGACTTAGAATCGTTTCTGCCAGGAAAACAGAGGCGGGTAGACAGGAAACCCCAGGTTCTGAAAGAACTGGAAAATCTTTTACAAATGTTCGAAGAAGGTTTGCCCTGCATTGAACACGCTTTAAAGGAACAACTTATTTCAACGCCTATCAAGGATAATGAGCATTAA","protein_sequence":"MSNYYRRAHASSGSYRQPQEQPQYSRSGHYQYSNGHSHQQYSSQYNQRRRYNHNDGTRRRYNDDRPHSSNNASTRQYYATNNSQSGPYVNKKSDISSRRGMSQSRYSNSNVHNTLASSSGSLPTESALLLQQRPPSVLRYNTDNLKSKFHYFDPIKGEFFNKDKMLSWKATDKEFSETGYYVVKELQDGQFKFKIKHRHPEIKASDPRNENGIMTSGKVATHRKCRNSLILLPRISYDRYSLGPPPSCEIVVYPAQDSTTTNIQDISIKNYFKKYGEISHFEAFNDPNSALPLHVYLIKYASSDGKINDAAKAAFSAVRKHESSGCFIMGFKFEVILNKHSILNNIISKFVEINVKKLQKLQENLKKAKEKEAENEKAKELQGKDITLPKEPKVDTLSHSSGSEKRIPYDLLGVVNNRPVLHVSKIFVAKHRFCVEDFKYKLRGYRCAKFIDHPTGIYIIFNDIAHAQTCSNAESGNLTIMSRSRRIPILIKFHLILPRFQNRTRFNKSSSSSNSTNVPIKYESKEEFIEATAKQILKDLEKTLHVDIKKRLIGPTVFDALDHANFPELLAKRELKEKEKRQQIASKIAEDELKRKEEAKRDFDLFGLYGGYAKSNKRNLKRHNSLALDHTSLKRKKLSNGIKPMAHLLNEETDSKETTPLNDEGITRVSKEHDEEDENMTSSSSEEEEEEAPDKKFKSESEPTTPESDHLHGIKPLVPDQNGSSDVLDASSMYKPTATEIPEPVYPPEEYDLKYSQTLSSMDLQNAIKDEEDMLILKQLLSTYTPTVTPETSAALEYKIWQSRRKVLEEEKASDWQIELNGTLFDSELQPGSSFKAEGFRKIADKLKINYLPHRRRVHQPLNTVNIHNERNEYTPELCQREESSNKEPSDSVPQEVSSSRDNRASNRRFQQDIEAQKAAIGTESELLSLNQLNKRKKPVMFARSAIHNWGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRVDENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYDYKFEREKDDEERLPCLCGAPNCKGFLN"}]}