{"ymdb_id":"YMDB00653","created_at":"2011-05-29T18:40:36.000Z","updated_at":"2016-09-08T18:35:44.000Z","name":"Hydrogen sulfide","cas":"7783-06-4","state":"Liquid","melting_point":"-85.49 oC","description":"Hydrogen sulfide (H2S) is a powerful aroma compound largely produced by yeast during fermentation. Its occurrence in wines and other fermented beverages has been associated with off-odors described as rotten egg and/or sewage. In wine fermentations, H2S is largely formed by reduction of exogenous sulfate during the biosynthesis of the sulfur-containing amino acids cysteine and methionine. Sulfite, which is commonly added to grape musts as an antioxidant and antimicrobial agent, can also enter the cell and become a source of H2S, after reduction by sulfite reductase. [Biocyc SO4ASSIM-PWY] [PMID: 20668912]","experimental_water_solubility":"3.74 mg/mL at 21 oC [VENABLE,CS \u0026 FUWA,T (1922)]","experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":null,"chebi_id":"16136","hmdb_id":"HMDB03276","kegg_id":"C00283","pubchem_id":"402","cs_id":"391","foodb_id":null,"wikipedia_link":"Hydrogen_sulfide","biocyc_id":"HS","iupac":"hydrogen sulfide","traditional_iupac":"hydrogen sulfide","logp":"-0.03749999999999998","pka":null,"alogps_solubility":null,"alogps_logp":null,"alogps_logs":null,"acceptor_count":"0","donor_count":"1","rotatable_bond_count":"0","polar_surface_area":"0.0","refractivity":"7.3558","polarizability":"3.450817136572978","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":null,"pka_strongest_acidic":null,"bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"1","mddr_like_rule":"0","synonyms":["acide sulfhydrique","Dihydrogen disulfide","Dihydrogen monosulfide","Dihydrogen sulfide","H2S","Hepatate","Hepatic acid","Hepatic gas","Hydrogen monosulfide","Hydrogen sulfide","Hydrogen sulfide (H2S)","hydrogen sulphide","Hydrogen-sulfide","Hydrogen-sulphide-","Hydrogene sulfure","Hydrosulfurate","Hydrosulfuric acid","Idrogeno solforato","Schwefelwasserstoff","Sewer gas","Siarkowodor","Sour gas","Stink damp","Sulfide","Sulfur hydride","Sulfur hydroxide","Sulfureted hydrogen","Sulfuretted hydrogen"],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Sulfur metabolism","kegg_map_id":"00920"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":11010893,"citation":"Spiropoulos, A., Bisson, L. F. (2000). \"MET17 and hydrogen sulfide formation in Saccharomyces cerevisiae.\" Appl Environ Microbiol 66:4421-4426."},{"pubmed_id":15042590,"citation":"Mulet, J. M., Alemany, B., Ros, R., Calvete, J. J., Serrano, R. (2004). \"Expression of a plant serine O-acetyltransferase in Saccharomyces cerevisiae confers osmotic tolerance and creates an alternative pathway for cysteine biosynthesis.\" Yeast 21:303-312."},{"pubmed_id":9003798,"citation":"Hansen, J., Muldbjerg, M., Cherest, H., Surdin-Kerjan, Y. (1997). \"Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes.\" FEBS Lett 401:20-24."}],"proteins":[{"created_at":"2011-05-26T16:28:32.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"Putative cysteine synthase","uniprot_id":"P53206","uniprot_name":"CYSK_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":393,"molecular_weight":"42800.5","theoretical_pi":"8.37","general_function":"Involved in cysteine biosynthetic process from serine","specific_function":"O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate","reactions":[{"id":1422,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2420,"direction":"\u003e","locations":"Cytoplasm","altext":"O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate.","export":false,"pw_reaction_id":null,"source":null},{"id":14424,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006937","source":"Smpdb"},{"id":14424,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006937","source":"Smpdb"},{"id":14425,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006938","source":"Smpdb"},{"id":14425,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006938","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"Z72797","genbank_protein_id":"1322974","gene_card_id":null,"chromosome_location":null,"locus":"YGR012W","synonyms":["CSase","O-acetylserine (thiol)-lyase","OAS-TL","O-acetylserine sulfhydrylase"],"enzyme_classes":["2.5.1.47"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" serine family amino acid metabolic process"},{"category":"Process","description":" L-serine metabolic process"},{"category":"Process","description":" cysteine biosynthetic process from serine"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"PALP","identifier":"PF00291"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGTCCTGTTCTCAAAATAAGACTTCTGTCAGTCTGGCCTGGCGTGAATGCATATCCATCGCTTCCGTCCTAATTGGCGCGTATGCATCATACAAATACTATAAGCTGTTCAAAACACGCGATATTCCACGTCCAAAAGAAGGCGTTGAAGAACTCATAGGAAACACTCCTCTGGTTAAGATCAGATCTCTTACCAAGGCTACTGGAGTTAACATTTACGCTAAGTTGGAGTTATGCAACCCAGCAGGAAGTGCTAAGGATAGAGTGGCTTTAAACATCATAAAGACGGCTGAGGAATTAGGCGAGCTCGTCAGAGGTGAACCTGGCTGGGTATTTGAAGGAACAAGTGGGTCGACTGGTATCTCTATAGCAGTGGTCTGTAATGCGTTGGGTTATAGGGCACACATTTCTTTGCCCGATGACACATCGCTAGAAAAATTGGCATTACTAGAAAGCCTCGGTGCTACTGTTAATAAGGTTAAGCCCGCTAGTATTGTCGATCCAAACCAATACGTAAATGCCGCCAAAAAGGCATGTAATGAACTAAAGAAGAGTGGTAATGGAATAAGAGCAGTTTTTGCCGATCAGTTCGAAAACGAAGCCAACTGGAAAGTACATTACCAGACCACAGGCCCAGAAATTGCCCATCAAACTAAGGGAAATATTGACGCATTCATTGCTGGCTGCGGTACTGGTGGCACCATAACTGGTGTGGCAAAATTCTTAAAGGAAAGAGCAAAGATACCTTGCCATGTCGTTCTAGCGGATCCACAAGGATCTGGCTTTTATAATAGAGTCAACTATGGCGTGATGTATGACTATGTAGAGAAGGAAGGTACTAGAAGAAGGCATCAAGTTGACACTATCGTAGAAGGGATTGGGTTAAACAGAATCACTCATAATTTTCATATGGGCGAAAAGTTTATTGATGAATCAATACGAGTCAACGATAATCAAGCCATTAGAATGGCAAAATACCTATCGGTAAACGACGGGCTATTCGTGGGGAGTAGTACAGCTATTAATGCGGTAGCCGCTATTCAGGTTGCAAAAACGCTTCCTCACGGCTCAAACATTGTGATTATTGCATGCGACAGCGGTTCAAGACACCTAAGTAAATTCTGGAAAGAAGCTAAAGAAATCGATCACGACGTGTCATTAGAAGAAGTAATAAATATCTAA","protein_sequence":"MSCSQNKTSVSLAWRECISIASVLIGAYASYKYYKLFKTRDIPRPKEGVEELIGNTPLVKIRSLTKATGVNIYAKLELCNPAGSAKDRVALNIIKTAEELGELVRGEPGWVFEGTSGSTGISIAVVCNALGYRAHISLPDDTSLEKLALLESLGATVNKVKPASIVDPNQYVNAAKKACNELKKSGNGIRAVFADQFENEANWKVHYQTTGPEIAHQTKGNIDAFIAGCGTGGTITGVAKFLKERAKIPCHVVLADPQGSGFYNRVNYGVMYDYVEKEGTRRRHQVDTIVEGIGLNRITHNFHMGEKFIDESIRVNDNQAIRMAKYLSVNDGLFVGSSTAINAVAAIQVAKTLPHGSNIVIIACDSGSRHLSKFWKEAKEIDHDVSLEEVINI"},{"created_at":"2011-05-26T16:30:36.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Protein MET17","uniprot_id":"P06106","uniprot_name":"MET17_YEAST","enzyme":true,"transporter":false,"gene_name":"MET17","num_residues":444,"molecular_weight":"48671.39844","theoretical_pi":"6.41","general_function":"Involved in pyridoxal phosphate binding","specific_function":"Transforms O-acetylhomoserine into homocysteine and O- acetylserine into cysteine","reactions":[{"id":1797,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1798,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2422,"direction":"\u003e","locations":"Cytoplasm","altext":"O-acetyl-L-homoserine + methanethiol = L-methionine + acetate.","export":false,"pw_reaction_id":null,"source":null},{"id":2420,"direction":"\u003e","locations":"Cytoplasm","altext":"O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate.","export":false,"pw_reaction_id":null,"source":null},{"id":3775,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006297","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY723848","genbank_protein_id":"51830472","gene_card_id":"MET17","chromosome_location":"chromosome 12","locus":"YLR303W","synonyms":["O-acetylhomoserine sulfhydrylase","OAH sulfhydrylase","Homocysteine synthase","O-acetylserine sulfhydrylase","OAS sulfhydrylase"],"enzyme_classes":["2.5.1.49","2.5.1.47"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" transferase activity, transferring alkyl or aryl (other than methyl) groups"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGCCATCTCATTTCGATACTGTTCAACTACACGCCGGCCAAGAGAACCCTGGTGACAATGCTCACAGATCCAGAGCTGTACCAATTTACGCCACCACTTCTTATGTTTTCGAAAACTCTAAGCATGGTTCGCAATTGTTTGGTCTAGAAGTTCCAGGTTACGTCTATTCCCGTTTCCAAAACCCAACCAGTAATGTTTTGGAAGAAAGAATTGCTGCTTTAGAAGGTGGTGCTGCTGCTTTGGCTGTTTCCTCCGGTCAAGCCGCTCAAACCCTTGCCATCCAAGGTTTGGCACACACTGGTGACAACATCGTTTCCACTTCTTACTTATACGGTGGTACTTATAACCAGTTCAAAATCTCGTTCAAAAGATTTGGTATCGAGGCTAGATTTGTTGAAGGTGACAATCCAGAAGAATTCGAAAAGGTCTTTGATGAAAGAACCAAGGCTGTTTATTTGGAAACCATTGGTAATCCAAAGTACAATGTTCCGGATTTTGAAAAAATTGTTGCAATTGCTCACAAACACGGTATTCCAGTTGTCGTTGACAACACATTTGGTGCCGGTGGTTACTTCTGTCAGCCAATTAAATACGGTGCTGATATTGTAACACATTCTGCTACCAAATGGATTGGTGGTCATGGTACTACTATCGGTGGTATTATTGTTGACTCTGGTAAGTTCCCATGGAAGGACTACCCAGAAAAGTTCCCTCAATTCTCTCAACCTGCCGAAGGATATCACGGTACTATCTACAATGAAGCCTACGGTAACTTGGCATACATCGTTCATGTTAGAACTGAACTATTAAGAGATTTGGGTCCATTGATGAACCCATTTGCCTCTTTCTTGCTACTACAAGGTGTTGAAACATTATCTTTGAGAGCTGAAAGACACGGTGAAAATGCATTGAAGTTAGCCAAATGGTTAGAACAATCCCCATACGTATCTTGGGTTTCATACCCTGGTTTAGCATCTCATTCTCATCATGAAAATGCTAAGAAGTATCTATCTAACGGTTTCGGTGGTGTCTTATCTTTCGGTGTAAAAGACTTACCAAATGCCGACAAGGAAACTGACCCATTCAAACTTTCTGGTGCTCAAGTTGTTGACAATTTAAAGCTTGCCTCTAACTTGGCCAATGTTGGTGATGCCAAGACCTTAGTCATTGCTCCATACTTCACTACCCACAAACAATTAAATGACAAAGAAAAGTTGGCATCTGGTGTTACCAAGGACTTAATTCGTGTCTCTGTTGGTATCGAATTTATTGATGACATTATTGCAGACTTCCAGCAATCTTTTGAAACGGTTTTCGCTGGCCAAAAACCATGA","protein_sequence":"MPSHFDTVQLHAGQENPGDNAHRSRAVPIYATTSYVFENSKHGSQLFGLEVPGYVYSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTYNQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHKHGIPVVVDNTFGAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDYPEKFPQFSQPAEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLRAERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKKYLSNGFGGVLSFGVKDLPNADKETDPFKLSGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDLIRVSVGIEFIDDIIADFQQSFETVFAGQKP"},{"created_at":"2011-05-26T16:31:10.000Z","updated_at":"2011-07-22T17:54:32.000Z","name":"Cystathionine gamma-lyase","uniprot_id":"P31373","uniprot_name":"CYS3_YEAST","enzyme":true,"transporter":false,"gene_name":"CYS3","num_residues":394,"molecular_weight":"42541.69922","theoretical_pi":"6.52","general_function":"Involved in pyridoxal phosphate binding","specific_function":"L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate","reactions":[{"id":1420,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2423,"direction":"\u003e","locations":"Cytoplasm","altext":"L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate.","export":false,"pw_reaction_id":null,"source":null},{"id":3779,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006300","source":"Smpdb"},{"id":3780,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006305","source":"Smpdb"},{"id":14294,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006775","source":"Smpdb"},{"id":14295,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006796","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1N8P","cellular_location":"Cytoplasm","genbank_gene_id":"D14135","genbank_protein_id":"416164","gene_card_id":"CYS3","chromosome_location":"chromosome 1","locus":"YAL012W","synonyms":["Gamma-cystathionase","Sulfur transfer protein 1"],"enzyme_classes":["4.4.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"Cys_Met_Meta_PP","identifier":"PF01053"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGACTCTACAAGAATCTGATAAATTTGCTACCAAGGCCATTCATGCCGGTGAACATGTGGACGTTCACGGTTCCGTGATCGAACCCATTTCTTTGTCCACCACTTTCAAACAATCTTCTCCAGCTAACCCTATCGGTACTTACGAATACTCCAGATCTCAAAATCCTAACAGAGAGAACTTGGAAAGAGCAGTTGCCGCTTTAGAGAACGCTCAATACGGGTTGGCTTTCTCCTCTGGTTCTGCCACCACCGCCACAATCTTGCAATCGCTTCCTCAGGGCTCCCATGCGGTCTCTATCGGTGATGTGTACGGTGGTACCCACAGATACTTCACCAAAGTCGCCAACGCTCACGGTGTGGAAACCTCCTTCACTAACGATTTGTTGAACGATCTACCTCAATTGATAAAGGAAAACACCAAATTGGTCTGGATCGAAACCCCAACCAACCCAACTTTGAAGGTCACCGACATCCAAAAGGTGGCAGACCTTATCAAGAAGCACGCTGCCGGCCAAGACGTGATCTTGGTTGTCGACAACACCTTCTTGTCCCCATATATCTCCAATCCATTGAACTTCGGTGCAGACATCGTTGTCCACTCCGCTACAAAGTACATCAACGGTCACTCAGACGTTGTGCTCGGTGTCCTGGCCACTAATAACAAGCCATTGTACGAGCGTCTGCAGTTCTTACAAAACGCCATTGGTGCTATCCCATCTCCTTTCGATGCTTGGTTGACCCACAGAGGTTTGAAGACTTTGCATCTACGTGTCAGACAAGCTGCCCTCAGCGCCAACAAAATCGCTGAATTCTTGGCAGCAGACAAGGAAAACGTTGTCGCAGTCAACTACCCAGGTTTGAAGACACACCCTAACTACGACGTAGTGTTAAAGCAACACCGTGATGCCCTTGGTGGTGGTATGATCTCCTTCAGAATCAAGGGTGGTGCTGAAGCTGCTTCCAAGTTCGCCTCCTCCACAAGACTGTTCACATTGGCCGAATCCCTTGGTGGTATCGAATCTCTATTGGAAGTGCCCGCTGTGATGACCCACGGTGGTATCCCAAAGGAGGCCAGAGAGGCCTCTGGTGTTTTTGACGACTTGGTTAGAATCTCTGTCGGTATTGAAGACACTGACGATCTTTTGGAAGACATCAAGCAAGCCTTGAAACAAGCCACCAACTAA","protein_sequence":"MTLQESDKFATKAIHAGEHVDVHGSVIEPISLSTTFKQSSPANPIGTYEYSRSQNPNRENLERAVAALENAQYGLAFSSGSATTATILQSLPQGSHAVSIGDVYGGTHRYFTKVANAHGVETSFTNDLLNDLPQLIKENTKLVWIETPTNPTLKVTDIQKVADLIKKHAAGQDVILVVDNTFLSPYISNPLNFGADIVVHSATKYINGHSDVVLGVLATNNKPLYERLQFLQNAIGAIPSPFDAWLTHRGLKTLHLRVRQAALSANKIAEFLAADKENVVAVNYPGLKTHPNYDVVLKQHRDALGGGMISFRIKGGAEAASKFASSTRLFTLAESLGGIESLLEVPAVMTHGGIPKEAREASGVFDDLVRISVGIEDTDDLLEDIKQALKQATN"},{"created_at":"2011-05-27T02:03:54.000Z","updated_at":"2011-05-27T02:03:54.000Z","name":"Sulfite reductase [NADPH] subunit beta","uniprot_id":"P47169","uniprot_name":"ECM17_YEAST","enzyme":true,"transporter":false,"gene_name":"ECM17","num_residues":1442,"molecular_weight":"161218.0","theoretical_pi":"5.15","general_function":"Involved in iron ion binding","specific_function":"Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate","reactions":[{"id":1992,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2657,"direction":"\u003e","locations":"Cytoplasm","altext":"H(2)S + 3 NADP(+) + 3 H(2)O = sulfite + 3 NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":14423,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006936","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z49637","genbank_protein_id":"1015876","gene_card_id":"ECM17","chromosome_location":null,"locus":"YJR137C","synonyms":["Extracellular mutant protein 17"],"enzyme_classes":["1.8.1.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" FMN binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Flavodoxin_1","identifier":"PF00258"},{"name":"NIR_SIR","identifier":"PF01077"},{"name":"NIR_SIR_ferr","identifier":"PF03460"}],"pathways":[{"name":"Sulfur 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PLYRFNPVYDDPSTDKEAFSLDSSVIRKQLQDFLDRENKLTLLTRKDPSLSRNLKQSAGDALTRKQEKRSKAAFDQLLEGLSGPPLHVYYASDGGNAANLAKRLAARASARGLKATVLSMDDIILEELPGEENVVFITSTAGQGEFPQDGKSFWEALKNDTDLDLASLNVAVFGLGDSEYWPRKEDKHYFNKPSQDLFKRLELLSAKALIPLGLGDDQDADGFQTAYSEWEPKLWEALGVSGAAVDDEPKPVTNEDIKRESNFLRGTISENLKDTSSGGVTHANEQLMKFHGIYTQDDRDIREIRKSQGLEPYYMFMARARLPGGKTTPQQWLALDHLSDTSGNGTLKLTTRATFQIHGVLKKNLKHTLRGMNAVLMDTLAAAGDVNRNVMVSALPTNAKVHQQIADMGKLISDHFLPKTTAYHEVWLEGPEEQDDDPSWPSIFENRKDGPRKKKTLVSGNALVDIEPIYGPTYLPRKFKFNIAVPPYNDVDVLSIDVGLVAIVNPETQIVEGYNVFVGGGMGTTHNNKKTYPRLGSCLGFVKTEDIIPPLEGIVIVQRDHGDRKDRKHARLKYTVDDMGVEGFKQKVEEYWGKKFEPERPFEFKSNIDYFGWIKDETGLNHFTAFIENGRVEDTPDLPQKTGIRKVAEYMLKTNSGHFRLTGNQHLVISNITDEHVAGIKSILKTYKLDNTDFSGLRLSSSSCVGLPTCGLAFAESERFLPDIITQLEDCLEEYGLRHDSIIMRMTGCPNGCSRPWLGELALVGKAPHTYNLMLGGGYLGQRLNKLYKANVKDEEIVDYIKPLFKRYALEREEGEHFGDFCIRVGIIKPTTEGKYFHEDVSEDAY"},{"created_at":"2011-05-27T02:05:04.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Sulfite reductase [NADPH] flavoprotein component","uniprot_id":"P39692","uniprot_name":"MET10_YEAST","enzyme":true,"transporter":false,"gene_name":"MET10","num_residues":1035,"molecular_weight":"114827.0","theoretical_pi":"4.91","general_function":"Involved in oxidoreductase activity","specific_function":"This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate","reactions":[{"id":1992,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2657,"direction":"\u003e","locations":"Cytoplasm","altext":"H(2)S + 3 NADP(+) + 3 H(2)O = sulfite + 3 NADPH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D44610","genbank_protein_id":"624931","gene_card_id":"MET10","chromosome_location":"chromosome 6","locus":"YFR030W","synonyms":[],"enzyme_classes":["1.8.1.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"NAD_binding_1","identifier":"PF00175"},{"name":"FAD_binding_1","identifier":"PF00667"}],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGCCAGTTGAGTTTGCTACCAATCCTTTTGGCGAGGCCAAAAATGCAACTTCACTGCCAAAATATGGTACACCCGTAACTGCCATTTCATCTGTGCTGTTCAATAACGTGGACTCCATTTTTGCTTACAAGTCCTTTTCTCAACCCGATTTGCTACACCAAGATCTAAAAAAATGGTCTGAAAAGCGTGGTAACGAATCACGTGGGAAGCCATTTTTCCAAGAGCTGGATATCAGATCTGGCGCTGGTTTGGCTCCTTTAGGGTTTTCTCATGGATTGAAGAACACTACAGCAATTGTTGCTCCAGGGTTTTCGCTGCCATACTTCATTAACTCTTTGAAAACCGTCTCTCATGATGGTAAGTTTCTTTTGAATGTTGGTGCTTTAAACTACGACAATGCTACCGGCTCTGTCACCAACGATTATGTAACCGCATTGGATGCTGCTTCCAAGCTGAAGTATGGTGTCGTGACTCCGATTTCCGCTAACGAGGTACAAAGTGTCGCCTTACTGACATTGGCGATTGCCACTTTCAGTAATAACTCCGGAGCTATCAATTTATTTGACGGATTAAACTACTCGAAAACCGTCTTGCCGTTGGTCGAATCTGTTCCTGAGGCATCTATTTTGGCAAAACTATCCAAAGTTATTGCACCAGATGCTGCCTTTGATGATGTCTTGGATAAGTTTAATGAATTGACTGGATTGAGACTACATAATTTCCAATACTTTGGTGCTCAGGATGCTGAAACTGTGTTTATCACTTATGGGTCTTTAGAATCCGAATTGTTCAACTCTGCGATTAGTGGTAATAATTCCAAAATCGGGTTAATCAACGTCAGAGTACCATTACCTTTTAACGTTGCTAAGTTTGTCACTCACGTTCCATCCACTACCAAACAAATTGTTGTTATAGGCCAAACTTTGGATGGTTCTTCGCCTTCTTTCTTGAGATCTCAAGTTTCAGCCGCCTTATTTTACCACGGCCGCACCTCAATTAGCGTTTCTGAGTACATCTATCAACCAGATTTCATTTGGTCCCCAAAAGCTGTCAAATCAATTGTATCGTCATTCATCCCTGAATTCACTTACAATGCCGATTCATCTTTCGGCGAAGGATTCATTTATTGGGCCTCTGATAAGAGTATCAATATTGATGTTGCCTCCAAACTTGTGAAAGCTCTGTCTTTGGAAGATGGGAAATTTGTGTCTTTGAGAACGAAATTTGATAACTTGGCTAATGCTGGTACCTTCCAAGCTCAATTTGTGACCTCGAAAGAACAGATACCTGTTTCAAACATCGATTCTACGAAATTATCAGTCGTTGAAGATGTCAGTTTATTGAAGCATTTAGACGTAGCTGCTACCGTCGCAGAACAAGGTTCAATTGCGTTGGTTTCCCAAAAGGCAGTTAAAGATTTGGATTTAAATTCTGTAGAAAGTTACGTCAAGAATTTGGGAATTCCTGAATCATTCCTAATATCTATTGCGAAGAAAAACATCAAATTGTTTATCATCGATGGTGAGACCACTAACGACGAGTCCAAATTGTCCTTGTTTATCCAAGCCGTTTTCTGGAAATTGGCCTTCGGTCTAGATGTCGCAGAATGTACCAACCGTATCTGGAAAAGCATTGATTCAGGTGCAGACATTTCAGCAGCCTCGATTTCTGAATTTCTCACTGGTGCATTCAAAAACTTCCTCAGTGAGGTTCCGCTAGCGCTGTACACTAAATTTTCTGAAATAAACATTGAAAAGAAAGAGGATGAGGAAGAGCCTGCAGCTTTACCAATTTTCGTTAATGAAACATCTTTCCTCCCAAATAACAGTACCATTGAAGAAATACCATTACCTGAGACCTCTGAGATCTCTGATATTGCCAAGAAGTTGTCCTTCAAAGAGGCATATGAAGTTGAGAATAAACTAAGACCCGATTTACCCGTCAAGAACTTCGTCGTGAAAGTTAAAGAAAATAGACGTGTTACGCCTGCTGATTATGATAGATATATTTTCCATATTGAATTCGATATTTCTGGTACTGGAATGACTTATGACATCGGTGAAGCCCTCGGTATTCATGCCAGAAACAATGAATCTTTGGTCAAAGAATTCTTAACCTTCTATGGTCTAAATGAATCCGATGTTGTCTTAGTCCCCAACAAGGACAACCACCATTTGTTAGAAACAAGAACCGTCTTACAAGCATTTGTGGAAAATTTGGATATTTTCGGTAAACCACCAAAAAGATTTTACGAATCATTGATTCCATATGCCTCTAACGAAGAGGAGAAGAAAAAATTAGAGGATTTGGTTACTCCTGCCGGTGCAGTAGATTTGAAGAGATTTCAAGATGTGGAGTATTATACATATGCTGACATTTTTGAATTGTTCCCATCTGTTCGCCCATCTCTTGAGGAACTTGTTACTATCATTGAACCATTGAAGAGAAGAGAATACTCAATTGCCTCCTCTCAGAAAGTTCATCCAAATGAAGTTCATTTATTGATCGTTGTTGTTGATTGGGTGGATAATAAAGGAAGAAAAAGGTACGGTCAAGCTTCTAAGTATATCTCAGACCTTGCTGTCGGTTCAGAATTGGTCGTTAGCGTTAAACCATCTGTTATGAAATTACCACCATCTCCAAAGCAACCAGTTATTATGAGTGGTTTAGGTACTGGTTTGGCACCATTCAAGGCCATTGTTGAAGAGAAATTATGGCAAAAGCAGCAAGGTTATGAGATTGGTGAAGTCTTCCTATATCTAGGTTCAAGACACAAAAGAGAAGAATATTTATATGGTGAGTTATGGGAGGCTTACAAAGATGCAGGTATTATCACACACATCGGCGCTGCTTTCTCAAGAGACCAACCTCAAAAAATTTACATTCAAGATCGTATCAAAGAGAATTTGGATGAATTAAAAACTGCAATGATTGATAATAAAGGTTCATTTTACTTGTGTGGCCCTACTTGGCCAGTTCCAGATATTACTCAAGCTTTGCAAGACATTCTGGCTAAAGACGCCGAGGAAAGAGGCATCAAAGTCGACTTGGATGCCGCAATTGAAGAATTAAAGGAAGCATCAAGATACATTTTAGAAGTCTACTAA","protein_sequence":"MPVEFATNPFGEAKNATSLPKYGTPVTAISSVLFNNVDSIFAYKSFSQPDLLHQDLKKWSEKRGNESRGKPFFQELDIRSGAGLAPLGFSHGLKNTTAIVAPGFSLPYFINSLKTVSHDGKFLLNVGALNYDNATGSVTNDYVTALDAASKLKYGVVTPISANEVQSVALLALAIATFSNNSGAINLFDGLNYSKTVLPLVESVPEASILAKLSKVIAPDAAFDDVLDKFNELTGLRLHNFQYFGAQDAETVFITYGSLESELFNSAISGNNSKIGLINVRVPLPFNVAKFVTHVPSTTKQIVVIGQTLDGSSPSFLRSQVSAALFYHGRTSISVSEYIYQPDFIWSPKAVKSIVSSFIPEFTYNADSSFGEGFIYWASDKSINIDVASKLVKALSLEDGKFVSLRTKFDNLANAGTFQAQFVTSKEQIPVSNIDSTKLSVVEDVSLLKHLDVAATVAEQGSIALVSQKAVKDLDLNSVESYVKNLGIPESFLISIAKKNIKLFIIDGETTNDESKLSLFIQAVFWKLAFGLDVAECTNRIWKSIDSGADISAASISEFLTGAFKNFLSEVPLALYTKFSEINIEKKEDEEEPAALPIFVNETSFLPNNSTIEEIPLPETSEISDIAKKLSFKEAYEVENKLRPDLPVKNFVVKVKENRRVTPADYDRYIFHIEFDISGTGMTYDIGEALGIHARNNESLVKEFLTFYGLNESDVVLVPNKDNHHLLETRTVLQAFVENLDIFGKPPKRFYESLIPYASNEEEKKKLEDLVTPAGAVDLKRFQDVEYYTYADIFELFPSVRPSLEELVTIIEPLKRREYSIASSQKVHPNEVHLLIVVVDWVDNKGRKRYGQASKYISDLAVGSELVVSVKPSVMKLPPSPKQPVIMSGLGTGLAPFKAIVEEKLWQKQQGYEIGEVFLYLGSRHKREEYLYGELWEAYKDAGIITHIGAAFSRDQPQKIYIQDRIKENLDELKTAMIDNKGSFYLCGPTWPVPDITQALQDILAKDAEERGIKVDLDAAIEELKEASRYILEVY"},{"created_at":"2016-09-09T22:45:36.000Z","updated_at":"2016-09-09T22:45:36.000Z","name":"Uncharacterized trans-sulfuration enzyme YHR112C","uniprot_id":"P38716","uniprot_name":null,"enzyme":false,"transporter":false,"gene_name":null,"num_residues":378,"molecular_weight":"42444.685","theoretical_pi":null,"general_function":"sulfur compound metabolic process","specific_function":null,"reactions":[{"id":14425,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006938","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"nucleus"},{"category":"Function","description":"cytoplasm"},{"category":"Function","description":"cystathionine beta-lyase activity"},{"category":"Function","description":"pyridoxal phosphate binding"},{"category":"Function","description":"sulfur compound metabolic process"}],"pfams":[],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGGTGGACTTGTCAACAGCTTTGATTCATGGCGATGATAAAGATAACAGGGTTACTGACGTGGCGCCCCCAATTAATGTCTCTACAACCTTCCGTTACGACGATGACGACCTAATTCCATGGACAGAGCGTGAAAACTTGGACTTTATGGAGAAGAAGCCCGTATATTCACGGCTAGCGCATCCAAATAGCACCAGATTAGAGAGTATCTTCTCAGAGATCCTCGATGGTTATGCTGTCATTTATTCTTCAGGGTTAGCTGCGTTCTATGCGGCAATGGTACATTACAACCCTAAGAAGATCTTTATCGGACAGAGCTACCATGGTGTTCGAGCAATTGCTAACATATTGACCCGTAATTACGGCATTGAGCAACACCCCTTGGAAGATATTGAAAAATGTGCTTCTGAAGGTGACATTGTCCATCTGGAATCTCCTGTAAACCCATATGGTACCTCTTCTGATATCGAGAGTTTGGCCCGCAGAGCTCATGCAAAAGGCGCCCTGCTTATAGTGGATTCCACATTCGCATCTCCTCCATTGCAATACGCATGGAATTTCGGAGCCGATATTGTCCTATACTCTGCTACTAAGTACTTTGGTGGTCATTCTGACTTGTTAAGTGGCGTCCTTGTAGTCAAAGAGGAAGCAACTTCCCGACAACTAAAAGACGACAGAATCTACTTGGGTACAAACGTGGCAAATTTGGAAAGTTTCATGTTGTTGCGATCCCTGAGAACCTACGAAATGAGAATAACCAAACAATCAGAAAATGCTACGAAATTAGTTAGATTTTTGTCAGATCACCAATCTGAATTTGACAAAGTATTGAAGACGATTTACCACTCTTCTTTACAAACAGAAGAGTTCGTTAAAAAGCAACTGGTAGGAGGATATGGTCCCGTTTTTGCTATCACTTTGTACACCAAAGAGCAGTGTAAACAATTACCCCTCAAGCTGAAATATTTCCATCATGCGACCTCACTGGGTGGAATTGAATCCCTTGTGGAATGGAGAGCAATGACTGACCCATATATCGACCAAACTTTAATAAGAGTATCTGTGGGCTGTGAATCCGCTAATGATTTGATTAAGGATTTGGCTTCGGCCTTGAAAGAATTGCAGGATGCAGCCTGA","protein_sequence":"MVDLSTALIHGDDKDNRVTDVAPPINVSTTFRYDDDDLIPWTERENLDFMEKKPVYSRLAHPNSTRLESIFSEILDGYAVIYSSGLAAFYAAMVHYNPKKIFIGQSYHGVRAIANILTRNYGIEQHPLEDIEKCASEGDIVHLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSEFDKVLKTIYHSSLQTEEFVKKQLVGGYGPVFAITLYTKEQCKQLPLKLKYFHHATSLGGIESLVEWRAMTDPYIDQTLIRVSVGCESANDLIKDLASALKELQDAA"},{"created_at":"2016-09-09T22:50:41.000Z","updated_at":"2016-09-09T22:50:41.000Z","name":"NADPH-dependent diflavin oxidoreductase 1","uniprot_id":"Q12181","uniprot_name":"TAH18","enzyme":false,"transporter":false,"gene_name":"TAH18","num_residues":623,"molecular_weight":"72327.29","theoretical_pi":null,"general_function":"small molecule metabolic process","specific_function":"Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of DRE2. Positively controls H(2)O(2)-induced cell death.","reactions":[{"id":14423,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006936","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["NADPH-dependent FMN and FAD-containing oxidoreductase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"oxidoreductase activity, acting on NAD(P)H"},{"category":"Function","description":"iron-sulfur cluster assembly"},{"category":"Function","description":"nitric oxide biosynthetic process"},{"category":"Function","description":"oxidation-reduction process"},{"category":"Function","description":"small molecule metabolic process"},{"category":"Function","description":"cytosol"},{"category":"Function","description":"mitochondrion"},{"category":"Function","description":"FMN binding"},{"category":"Function","description":"flavin adenine dinucleotide binding"},{"category":"Function","description":"NADP binding"},{"category":"Function","description":"NADPH-hemoprotein reductase activity"}],"pfams":[],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGTCATCGAGCAAGAAAATCGTCATCCTCTATGGATCGGAGACAGGTAACGCGCATGATTTTGCTACAATCTTATCCCATCGACTACATCGCTGGCATTTCTCCCATACATTTTGCTCCATTGGTGATTATGACCCACAGGATATCTTGAAATGCAGGTACCTTTTTATTATATGCTCCACAACAGGCCAAGGTGAATTACCAAGGAATGTCAATGCATTAAAAGGTGAAAGACCCGTCACGTTCTGGTCGTTTTTAAAGAGAAAGAATCTTCCGTCGAATTTGCTCAACCATATTCAAACTGCCATGCTTGGACTTGGTGATTCATCTTATCCTAAGTTTAACTACGGCATTAGAAAGCTACATCAGCGCATTGTCACACAATTGGGTGCTAATGAATTATTCGATAGATTGGAGGCTGACGACCAGGCTATGGCTGGTAGCAATAAGGGTACAGGTCTCGGAATTGAATCAGTATATTTTGAATATGAAAAGAAAGTCCTAAGCTTTCTTTTAAGTAAGTACCCCAACAGAAAGGTCAATGGCCAAATAATTAAGAGGGAAGAATTGGACCCTGAGGTTTACCTAGAGCCAGCATCCTACCTACAGCTTTCAGACGAACATGCCAATGAAAAGTTCACTAGCACCAAGGTTATATTCGAAGGTGATGAATCGTTAAAGGTTGGCAGAGTTAATATAAACAAAAGGATTACATCTGAAGGTCATTTCCAAGACGTGAGGCAGTTCAAGTTTAGTAATGTGGACAAGATTCAAGAAAACTATGAACCCGGTGATACAGTAACCATATATCCTTGCAATACAGATGAGGATGTTTCAAGATTCCTAGCAAATCAAAGCCATTGGTTAGAAATTGCGGACAAACCATTGAATTTCACCAGTGGAGTTCCTAATGATCTTAAGGATGGTGGATTAGTTCGCCCGATGACTTTAAGGAACTTGTTGAAATATCACTGTGATTTCATGAGCATTCCTAGAACAAGTTTTTTCTTGAAGATTTGGACCTTTGCAACTGATGTAACTAAGATGGAACGTGGCCAAGAACAACTGAATGATCAAAGAGAAAAATTGCGCCAATTTGCTACTGATCAAGATATGCAGGACTTATATGACTACTGTAATAGACCCAGAAGGTCAATTCTTGAAGTACTGGAAGATTTTATCTCCGTAAAGTTGCCCTGGAAATATGTGCTAGATTACTTGCCCATCATTAAACCAAGGTACTACTCTATATCTAGCGGCCCTGGGGATCCTAATATTGAATTAACAGTTGCGATAGTAAAATATAAAACTATCTTAAGGAAAATTCGAAGAGGAATTTGCACTAACTACATTGCACGATTGCAAGAGGGGGAACAGATAAGGTATAAGTTACAAAATAATCACATAATCAAAAAGGAATTTTTGAATAAACCTATGATTCTTGTCGGACCGGGTGTCGGTCTAGCACCATTATTATCAGTGGTTAAAGCGGAGATATCTAAAGATATCAAACTCCTCTTCGGTTGTAGATATAAAGATAAAGATTATATTTATAAAGATATGCTGGAAGATTGGTTCCGTAAGGGCAAAATTGCCTTACATTCATCCTTTTCCAGAGATGAGGAAAATTCACCAGGTGTTAAATATGTCCAAGACTACTTATGGAGATTAGGTGAGGAAATAACTAATTTGGTAGTTAATAAAGACGCCGTTTTTTTCTTATGTGGCTCATCAGGTAAAATGCCTATCCAAGTCAGATTAACATTCATTGAAATGTTAAAAAAATGGGGCAATTTTAGTGATGAAGAAACTGCCAAAAAATACCTGAAAGAAATGGAAAAATCTGATAGATATATCCAGGAAACTTGGTAG","protein_sequence":"MSSSKKIVILYGSETGNAHDFATILSHRLHRWHFSHTFCSIGDYDPQDILKCRYLFIICSTTGQGELPRNVNALKGERPVTFWSFLKRKNLPSNLLNHIQTAMLGLGDSSYPKFNYGIRKLHQRIVTQLGANELFDRLEADDQAMAGSNKGTGLGIESVYFEYEKKVLSFLLSKYPNRKVNGQIIKREELDPEVYLEPASYLQLSDEHANEKFTSTKVIFEGDESLKVGRVNINKRITSEGHFQDVRQFKFSNVDKIQENYEPGDTVTIYPCNTDEDVSRFLANQSHWLEIADKPLNFTSGVPNDLKDGGLVRPMTLRNLLKYHCDFMSIPRTSFFLKIWTFATDVTKMERGQEQLNDQREKLRQFATDQDMQDLYDYCNRPRRSILEVLEDFISVKLPWKYVLDYLPIIKPRYYSISSGPGDPNIELTVAIVKYKTILRKIRRGICTNYIARLQEGEQIRYKLQNNHIIKKEFLNKPMILVGPGVGLAPLLSVVKAEISKDIKLLFGCRYKDKDYIYKDMLEDWFRKGKIALHSSFSRDEENSPGVKYVQDYLWRLGEEITNLVVNKDAVFFLCGSSGKMPIQVRLTFIEMLKKWGNFSDEETAKKYLKEMEKSDRYIQETW"}]}