{"ymdb_id":"YMDB00058","created_at":"2011-05-29T15:52:46.000Z","updated_at":"2016-10-18T17:11:16.000Z","name":"Adenosine","cas":"58-61-7","state":"Solid","melting_point":"235.5 oC","description":"Adenosine is a purine nucleoside. It is formed by a molecule of adenine attached to a ribose sugar molecule. Adenosine is the RNA nucleoside A. Adenosine plays an important role in energy transfer as adenosine triphosphate (ATP) and adenosine diphosphate (ADP), as well as in signal transduction as cyclic adenosine monophosphate (cAMP).","experimental_water_solubility":"7 mg/mL [Adenocard product monograph]; 37 mg/mL [HMP experimental]","experimental_logp_hydrophobicity":"-1.05 [HANSCH,C ET AL. (1995)]","location":"extracellular;mitochondrion;cytoplasm","synthesis_reference":"Liao, Ben-ren; Yuan, Zhen-wen.  Synthesis of adenosine from inosine.    Huaxue Shiji  (2006),  28(10),  633-634.","chebi_id":"16335","hmdb_id":"HMDB00050","kegg_id":"C00212","pubchem_id":"60961","cs_id":"54923","foodb_id":null,"wikipedia_link":"Adenosine","biocyc_id":"ADENOSINE","iupac":"(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol","traditional_iupac":"adenosine","logp":"-2.0909638716666668","pka":"13.891216626641981","alogps_solubility":"1.40e+01 g/l","alogps_logp":"-1.21","alogps_logs":"-1.28","acceptor_count":"8","donor_count":"4","rotatable_bond_count":"2","polar_surface_area":"139.54","refractivity":"63.1956","polarizability":"25.28306076008305","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"3.921276940416587","pka_strongest_acidic":"12.45400327595609","bioavailability":"1","number_of_rings":"3","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose","1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-delta-Ribofuranose","6-Amino-9beta-D-ribofuranosyl-9H-purine","6-Amino-9beta-delta-ribofuranosyl-9H-purine","9-beta-D-Arabinofuranosyladenine","9-beta-D-Ribofuranosidoadenine","9-beta-D-Ribofuranosyl-9H-purin-6-amine","9-beta-d-Ribofuranosyladenine","9-beta-delta-Arabinofuranosyladenine","9-beta-delta-Ribofuranosidoadenine","9-beta-delta-Ribofuranosyl-9H-purin-6-amine","9-beta-delta-Ribofuranosyladenine","9beta-D-ribofuranosyl-9H-Purin-6-amine","9beta-D-Ribofuranosyladenine","9beta-delta-ribofuranosyl-9H-Purin-6-amine","9beta-delta-Ribofuranosyladenine","Adenine nucleoside","Adenine riboside","adenine-9beta-D-Ribofuranoside","adenine-9beta-delta-Ribofuranoside","Adenocard","Adenocor","Adenoscan","Adenosin","b-D-Adenosine","beta-Adenosine","beta-D-Adenosine","beta-delta-Adenosine","Boniton","Myocol","Nucleocardyl","Sandesin"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"growth_conditions":[{"growth_media":"hops, malted barley","concentration":"307.0","concentration_units":"\u0026#181;M","error":"15.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":11223943,"citation":"Lecoq, K., Belloc, I., Desgranges, C., Daignan-Fornier, B. (2001). \"Role of adenosine kinase in Saccharomyces cerevisiae: identification of the ADO1 gene and study of the mutant phenotypes.\" Yeast 18:335-342."},{"pubmed_id":16448171,"citation":"Almeida, C., Duarte, I. F., Barros, A., Rodrigues, J., Spraul, M., Gil, A. M. (2006). \"Composition of beer by 1H NMR spectroscopy: effects of brewing site and date of production.\" J Agric Food Chem 54:700-706."},{"pubmed_id":15556636,"citation":"Tehlivets, O., Hasslacher, M., Kohlwein, S. D. (2004). \"S-adenosyl-L-homocysteine hydrolase in yeast: key enzyme of methylation metabolism and coordinated regulation with phospholipid synthesis.\" FEBS Lett 577:501-506."},{"pubmed_id":10827169,"citation":"Vickers, M. F., Yao, S. Y., Baldwin, S. A., Young, J. D., Cass, C. E. (2000). \"Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes.\" J Biol Chem 275:25931-25938."}],"proteins":[{"created_at":"2011-05-24T19:11:36.000Z","updated_at":"2011-07-22T17:53:59.000Z","name":"Adenosine kinase","uniprot_id":"P47143","uniprot_name":"ADK_YEAST","enzyme":true,"transporter":false,"gene_name":"ADO1","num_residues":340,"molecular_weight":"36372.0","theoretical_pi":"4.77","general_function":"Involved in adenosine kinase activity","specific_function":"ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. ADO1 does not play a major role in adenine utilization in yeast. Its physiological role could primarily be to recycle adenosine produced by the methyl cycle","reactions":[{"id":1270,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2242,"direction":"\u003e","locations":null,"altext":"ATP + adenosine = ADP + AMP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY558082","genbank_protein_id":"45270054","gene_card_id":"ADO1","chromosome_location":"chromosome 10","locus":"YJR105W","synonyms":[],"enzyme_classes":["2.7.1.20"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide kinase activity"},{"category":"Function","description":" nucleoside kinase activity"},{"category":"Function","description":" adenosine kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" kinase activity"},{"category":"Process","description":" heterocycle biosynthetic process"},{"category":"Process","description":" purine salvage"},{"category":"Process","description":" purine ribonucleoside salvage"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular biosynthetic process"}],"pfams":[{"name":"PfkB","identifier":"PF00294"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGACCGCACCATTGGTAGTATTGGGTAACCCACTTTTAGATTTCCAAGCCGACGTCACGGCTGAATACCTGGCCAAGTATTCTCTAAAGGAAAACGACGCAATTTTGGTCGATGCCAAATCAGGCGATGCTAAGATGGCTATTTTTGACGAGCTCTTACAGATGCCAGAAACAAAGCTTGTTGCAGGTGGTGCTGCTCAAAACACTGCTAGAGGGGCAGCATACGTTTTGGGCGCCGGCCAGGTGGTGTACTTCGGTTCCGTCGGTAAGGACAAGTTCAGCGAGAGATTGCTTAACGAAAACGAAAAAGCTGGTGTCAAGTCTATGTACCAAGTTCAAAATGATATTGGTACCGGTAAGTGTGCCGCATTAATCACTGGCCATAACCGGTCCTTGGTCACTGACTTGGGTGCTGCCAATTTCTTTACTCCAGACCACTTGGACAAGCATTGGGACTTGGTCGAAGCAGCTAAGCTCTTCTACATCGGTGGTTTCCACTTGACCGTGTCTCCAGACGCTATCGTTAAGTTGGGCCAACATGCTAAAGAGAACAGCAAACCTTTCGTGTTGAACTTTAGTGCTCCTTTCATTCCTCATGTCTTCAAAGACGCATTGGCCAGAGTTTTGCCTTATGCTACCGTCATCATCGCTAACGAATCGGAGGCCGAAGCCTTTTGCGACGCCTTCCAATTAGACTGTGCCAACACTGATTTGGAAGCTATTGCTCAAAGAATTGTCAAGGACTCTCCAGTTGAAAAGACTGTCATCTTCACCCACGGTGTCGAACCAACAGTGGTCGTGTCCTCCAAGGGTACCAGCACATATCCAGTCAAACCTTTGGACTCTTCTAAGATCGTCGACACCAACGGTGCTGGTGACGCCTTCGCTGGTGGCTTTATGGCTGGGTTGACTAAAGGTGAAGATTTGGAAACCTCTATTGACATGGGTCAATGGCTAGCTGCTTTGTCTATTCAAGAAGTTGGTCCCTCTTACCCTTCCGAAAAAATATCTTACTCTAAATAG","protein_sequence":"MTAPLVVLGNPLLDFQADVTAEYLAKYSLKENDAILVDAKSGDAKMAIFDELLQMPETKLVAGGAAQNTARGAAYVLGAGQVVYFGSVGKDKFSERLLNENEKAGVKSMYQVQNDIGTGKCAALITGHNRSLVTDLGAANFFTPDHLDKHWDLVEAAKLFYIGGFHLTVSPDAIVKLGQHAKENSKPFVLNFSAPFIPHVFKDALARVLPYATVIIANESEAEAFCDAFQLDCANTDLEAIAQRIVKDSPVEKTVIFTHGVEPTVVVSSKGTSTYPVKPLDSSKIVDTNGAGDAFAGGFMAGLTKGEDLETSIDMGQWLAALSIQEVGPSYPSEKISYSK"},{"created_at":"2011-05-24T20:49:32.000Z","updated_at":"2011-07-22T17:54:36.000Z","name":"Purine nucleoside phosphorylase","uniprot_id":"Q05788","uniprot_name":"PNPH_YEAST","enzyme":true,"transporter":false,"gene_name":"PNP1","num_residues":311,"molecular_weight":"33754.60156","theoretical_pi":"7.31","general_function":"Involved in purine-nucleoside phosphorylase activity","specific_function":"Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules","reactions":[{"id":1447,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1915,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1916,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1917,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1918,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1919,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1920,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1921,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2012,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2349,"direction":"\u003e","locations":null,"altext":"Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY557950","genbank_protein_id":"45269792","gene_card_id":"PNP1","chromosome_location":"chromosome 12","locus":"YLR209C","synonyms":["PNP","Inosine phosphorylase"],"enzyme_classes":["2.4.2.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Function","description":" purine-nucleoside phosphorylase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Process","description":" nucleoside metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"}],"pfams":[{"name":"PNP_UDP_1","identifier":"PF01048"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Nicotinate and nicotinamide metabolism","kegg_map_id":"00760"}],"gene_sequence":"ATGAGTGATATCTTGAACGTAAGTCAACAACGTGAAGCAATTACCAAGGCCGCTGCGTATATTTCTGCTATTTTAGAACCACATTTCAAAAATACAACAAATTTCGAGCCTCCGAGAACTTTGATTATATGTGGTTCAGGGCTTGGTGGAATATCTACCAAGCTGTCTAGAGACAATCCACCCCCGGTAACAGTCCCATACCAAGACATCCCAGGATTCAAGAAAAGTACGGTTCCAGGTCATTCCGGTACACTAATGTTCGGATCTATGAATGGTTCACCAGTAGTATTAATGAATGGTCGTCTTCATGGATATGAAGGCAACACATTGTTTGAGACTACTTTTCCTATTAGAGTGCTTAACCACATGGGTCATGTTCGTAATTTAATTGTCACTAATGCCGCTGGTGGTATAAACGCGAAATATCAAGCCTGCGATTTGATGTGCATTTATGATCATTTAAATATCCCTGGCCTTGCTGGCCAGCACCCATTGAGAGGTCCTAACTTGGATGAAGATGGACCTCGTTTTTTAGCCTTGAGTGATGCATATGATCTGGAGTTGAGGAAGCTTTTATTTAAGAAATGGAAAGAGCTCAAGATTCAAAGGCCACTGCATGAAGGTACTTATACTTTTGTATCTGGACCCACTTTCGAAACAAGAGCAGAATCCAAAATGATAAGGATGTTGGGAGGAGATGCTGTCGGAATGAGTACTGTTCCCGAAGTCATTGTTGCAAGACATTGCGGATGGAGGGTTTTGGCCTTAAGTTTGATTACCAATACTTGCGTGGTGGATAGCCCTGCCAGTGCGTTGGACGAATCACCTGTACCCTTAGAAAAAGGCAAAGCGACTCACGCTGAAGTACTGGAGAATGGTAAAATCGCCTCTAATGACGTGCAAAACTTAATTGCTGCCGTAATGGGGGAATTATAA","protein_sequence":"MSDILNVSQQREAITKAAAYISAILEPHFKNTTNFEPPRTLIICGSGLGGISTKLSRDNPPPVTVPYQDIPGFKKSTVPGHSGTLMFGSMNGSPVVLMNGRLHGYEGNTLFETTFPIRVLNHMGHVRNLIVTNAAGGINAKYQACDLMCIYDHLNIPGLAGQHPLRGPNLDEDGPRFLALSDAYDLELRKLLFKKWKELKIQRPLHEGTYTFVSGPTFETRAESKMIRMLGGDAVGMSTVPEVIVARHCGWRVLALSLITNTCVVDSPASALDESPVPLEKGKATHAEVLENGKIASNDVQNLIAAVMGEL"},{"created_at":"2011-05-26T16:42:40.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Nucleoside transporter FUN26","uniprot_id":"P31381","uniprot_name":"FUN26_YEAST","enzyme":false,"transporter":true,"gene_name":"FUN26","num_residues":517,"molecular_weight":"58316.69922","theoretical_pi":"4.69","general_function":"Involved in nucleoside transmembrane transporter activity","specific_function":"Has broad nucleoside selectivity (uridine, ademosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes","reactions":[],"signal_regions":"None","transmembrane_regions":"76-96;116-136;151-171;174-194;214-234;243-263;344-364;367-387;411-431;446-466;492-512","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein (Potential)","genbank_gene_id":"L05146","genbank_protein_id":"171853","gene_card_id":"FUN26","chromosome_location":"chromosome 1","locus":"YAL022C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" nucleoside transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Nucleoside_tran","identifier":"PF01733"}],"pathways":[],"gene_sequence":"ATGAGTACTAGTGCGGACACTGATACCATCAAGAAGCCAATCCTTGCGGTGCCAGAGCCTGCACTGGCCGATACGCATTCAGAGGAGATATCACGCTCTGGAGAAGAACATGAATCAGAGAACAACGAGCACTCAGATGAAGAAGGCGATAATTATTCTGAAAGAGAGCAATCTGTGTCAACCGAACCACTGGATACATTGCCGTTAAGAAAAAAGTTGAAAAATCTTTCATATATTACATTTTTCGCCATAGGAATAGGTCTTTTATGGCCGTGGAACTGTATCCTCAGTGCCTCGCAATATTTTAAGCACGATATTTTCAAAGACACCTCCATTTGGGCAAAGATCTTCACAAGCTCTATGATGTCCTTTTCTACCATATCGTCAATGCTGTTCAACATCTACTTGGCCAAAAGACAGTACAAATACTCGAGAAGGGTCATAAACGGGCTTGTGTGGGAGATTATTGTCTTTACTGTCATGTGCTTCTTTACAATTTTGCATTTCCTTTTACCTAAATGGTTCAATTTCATGTTTATAATGATGCTTGTAGTGATCAGTTCCATGGGGACAGCCATGACACAGAATGGTATCATGGCCATAGCCAACGTCTTCGGTTCCGAGTACAGTCAAGGTGTCATGGTGGGGCAAGCCGTTGCTGGTGTCCTGCCCTCCCTAGTGCTTTTTGCCCTAGCTTTCATCGAGAACTCTTCTGTGTCTACTACGGGCGGGATTCTTCTATACTTTTTTACCACAACACTCGTGGTCACCATTTGTGTGGTCATGTTCAGCGTGAGCAAAATCAGTCGGAAAGTGAACGAGAATTGGAATGTGGAAGACGGACATATCACTGATGTGTTGTTAGGGTCTCTGCGCTCCAATGAGGAGGAAATCCGTATTGTTGGCCGCATTGACCAAATGGAGGATGAAGACCACCGCCGCACCAACGGCACTCGCGACGACAACGACGAAGGTGAGGAACTCCAACTAAAAGTGCCTTTCGAGGTCTTATTTGCCAAACTAAAGTACCTGGTTCTTTCCATATTCACCACGTTTGTCGTAACTCTTGTTTTTCCTGTATTTGCGTCTGCCACCTACGTGACAGGGCTTCCTTTAAGCAACGCACAGTACATACCTCTCATATTCACGCTGTGGAACCTAGGCGACCTTTACGGAAGAGTCATTGCCGACTGGCCCATGTTCCGTGACCAGAAATTTACGCCACGCAAAACCTTCATCTACTCATTGTTGCGGGTGGCCGCAATACCACTGTTCTTGATGTTCACAGCCATCACCTCCTCTTCAAGCGGCGATGAAGAGCACAATGGCTCCGTAATCGTTGACTTGTGTTACATGCTACTGCAGTTCCTTTTCGGCGTAACCAACGGGCACGTCATCTCTATGAGTTTCATGAAGGTGCCAGAGCAACTGGACAACGACGACGAGAAGGAAGCGGCCGGTGGATTCACTAATATTTTCGTTTCTACAGGACTAGCTCTGGGCAGCATCATAAGCTACGTATTCGTCTTCATAATTGACTTTATTATCAGGTAG","protein_sequence":"MSTSADTDTIKKPILAVPEPALADTHSEEISRSGEEHESENNEHSDEEGDNYSEREQSVSTEPLDTLPLRKKLKNLSYITFFAIGIGLLWPWNCILSASQYFKHDIFKDTSIWAKIFTSSMMSFSTISSMLFNIYLAKRQYKYSRRVINGLVWEIIVFTVMCFFTILHFLLPKWFNFMFIMMLVVISSMGTAMTQNGIMAIANVFGSEYSQGVMVGQAVAGVLPSLVLFALAFIENSSVSTTGGILLYFFTTTLVVTICVVMFSVSKISRKVNENWNVEDGHITDVLLGSLRSNEEEIRIVGRIDQMEDEDHRRTNGTRDDNDEGEELQLKVPFEVLFAKLKYLVLSIFTTFVVTLVFPVFASATYVTGLPLSNAQYIPLIFTLWNLGDLYGRVIADWPMFRDQKFTPRKTFIYSLLRVAAIPLFLMFTAITSSSSGDEEHNGSVIVDLCYMLLQFLFGVTNGHVISMSFMKVPEQLDNDDEKEAAGGFTNIFVSTGLALGSIISYVFVFIIDFIIR"},{"created_at":"2011-05-26T16:49:15.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Adenosine deaminase","uniprot_id":"P53909","uniprot_name":"ADA_YEAST","enzyme":true,"transporter":false,"gene_name":"AAH1","num_residues":347,"molecular_weight":"39634.69922","theoretical_pi":"5.07","general_function":"Involved in deaminase activity","specific_function":"Adenosine + H(2)O = inosine + NH(3)","reactions":[{"id":1266,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1268,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1440,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2446,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Adenosine + H(2)O = inosine + NH(3).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"Z46843","genbank_protein_id":"854497","gene_card_id":"AAH1","chromosome_location":"chromosome 14","locus":"YNL141W","synonyms":["Adenosine aminohydrolase"],"enzyme_classes":["3.5.4.4","3.5.4.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"},{"category":"Function","description":" hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" adenosine deaminase activity"},{"category":"Function","description":" deaminase activity"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" purine nucleoside monophosphate biosynthetic process"},{"category":"Process","description":" purine ribonucleoside monophosphate biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"}],"pfams":[{"name":"A_deaminase","identifier":"PF00962"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGGTTTCTGTGGAGTTTTTACAGGAGTTACCAAAATGTGAGCATCACTTGCATTTGGAAGGTACTCTAGAACCTGACCTATTGTTCCCATTAGCTAAAAGAAACGATATAATTCTACCTGAAGGTTTTCCTAAATCGGTCGAGGAATTAAACGAAAAGTATAAGAAGTTTCGTGATCTGCAGGATTTCTTAGATTACTATTATATTGGTACTAATGTCTTGATTAGTGAACAAGATTTCTTTGATTTGGCGTGGGCCTATTTTAAAAAAGTTCACAAACAAGGCTTGGTCCATGCTGAAGTGTTTTACGACCCTCAGTCACATACATCTAGGGGCATCTCCATAGAAACAGTCACTAAAGGTTTCCAAAGAGCTTGTGACAAAGCCTTCTCTGAATTTGGTATTACATCCAAGCTAATTATGTGTCTGTTAAGACACATTGAACCAGAGGAATGTTTGAAAACTATCGAAGAAGCTACCCCATTTATTAAAGATGGTACTATCTCTGCCTTAGGATTAGATTCTGCTGAGAAACCATTTCCCCCACATTTATTTGTTGAATGTTACGGAAAGGCCGCCTCATTGAATAAAGATTTAAAACTAACTGCACACGCAGGTGAAGAAGGCCCCGCTCAATTCGTCTCGGATGCTTTAGACTTGTTGCAAGTAACAAGAATCGATCACGGTATCAACAGTCAATACGACGAGGAGTTATTGGATAGGTTGTCGCGCGACCAGACCATGCTAACTATTTGTCCTCTCTCCAACGTGAAGCTACAAGTAGTCCAATCCGTTTCAGAGTTACCACTACAAAAGTTTCTTGACAGAGATGTTCCATTTTCTTTAAATTCTGATGACCCCGCCTATTTTGGTGGTTATATCTTAGATGTCTACACTCAAGTTTCGAAAGATTTCCCACACTGGGACCATGAAACATGGGGTCGTATCGCTAAGAACGCCATTAAAGGTTCATGGTGTGACGATAAAAGAAAGAACGGTTTGTTAAGTAGAGTGGACGAAGTAGTCACTAAATATTCGCATTAG","protein_sequence":"MVSVEFLQELPKCEHHLHLEGTLEPDLLFPLAKRNDIILPEGFPKSVEELNEKYKKFRDLQDFLDYYYIGTNVLISEQDFFDLAWAYFKKVHKQGLVHAEVFYDPQSHTSRGISIETVTKGFQRACDKAFSEFGITSKLIMCLLRHIEPEECLKTIEEATPFIKDGTISALGLDSAEKPFPPHLFVECYGKAASLNKDLKLTAHAGEEGPAQFVSDALDLLQVTRIDHGINSQYDEELLDRLSRDQTMLTICPLSNVKLQVVQSVSELPLQKFLDRDVPFSLNSDDPAYFGGYILDVYTQVSKDFPHWDHETWGRIAKNAIKGSWCDDKRKNGLLSRVDEVVTKYSH"},{"created_at":"2011-05-26T16:49:52.000Z","updated_at":"2011-07-22T17:54:00.000Z","name":"Adenosylhomocysteinase","uniprot_id":"P39954","uniprot_name":"SAHH_YEAST","enzyme":true,"transporter":false,"gene_name":"SAH1","num_residues":449,"molecular_weight":"49125.10156","theoretical_pi":"6.2","general_function":"Involved in adenosylhomocysteinase activity","specific_function":"Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine","reactions":[{"id":1272,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2447,"direction":"\u003e","locations":"Cytoplasmic","altext":"S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.","export":false,"pw_reaction_id":null,"source":null},{"id":3786,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006308","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"AY692801","genbank_protein_id":"51013053","gene_card_id":"SAH1","chromosome_location":"chromosome 5","locus":"YER043C","synonyms":["AdoHcyase","S-adenosyl-L-homocysteine hydrolase"],"enzyme_classes":["3.3.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ether bonds"},{"category":"Function","description":" trialkylsulfonium hydrolase activity"},{"category":"Function","description":" adenosylhomocysteinase activity"},{"category":"Process","description":" one-carbon metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"AdoHcyase","identifier":"PF05221"},{"name":"AdoHcyase_NAD","identifier":"PF00670"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGTCTGCTCCAGCTCAAAACTACAAAATCGCTGATATCTCTTTGGCTGCCTTCGGTAGAAAGGAAATCGAATTGGCTGAACATGAAATGCCAGGTTTGATGGCCATCAGAAAGGCTTACGGTGACGTCCAACCTTTGAAAGGCGCCCGTATTGCTGGTTGTTTGCACATGACCATTCAAACTGCTGTTTTAATTGAAACTTTAGTTGCTTTGGGTGCCGAAGTTACCTGGTCCTCTTGTAACATCTATTCGACTCAAGATCATGCCGCCGCTGCTATTGCCGCTTCCGGTGTTCCAGTTTTTGCCTGGAAGGGTGAAACTGAAGAAGAGTATTTGTGGTGTATTGAACAACAATTGTTTGCCTTCAAGGACAACAAGAAATTGAACTTGATCTTAGATGATGGTGGTGATTTAACCACTTTAGTTCATGAAAAGCACCCTGAAATGCTGGAAGACTGCTTTGGTCTTTCCGAAGAAACTACCACCGGTGTTCACCACTTATACAGAATGGTCAAAGAAGGCAAGTTAAAGGTTCCTGCCATTAACGTTAACGACTCCGTCACTAAGTCCAAGTTTGACAACTTGTACGGCTGTAGAGAATCCTTAGTCGACGGTATTAAGAGAGCCACTGATGTCATGTTGGCTGGTAAGGTTGCCGTTGTTGCTGGTTACGGTGATGTCGGTAAGGGTTGTGCTGCTGCCTTAAGAGGAATGGGTGCTCGTGTCTTGGTTACCGAAATTGACCCAATCAACGCTTTACAAGCTGCCATGGAAGGCTACCAAGTTGTTACCATGGAAGATGCATCCCACATTGGTCAAGTTTTCGTTACCACCACTGGTTGTAGAGATATTATCAACGGTGAACATTTCATCAACATGCCAGAAGATGCCATTGTTTGTAACATTGGCCATTTCGATATCGAAATTGATGTCGCCTGGTTAAAGGCTAACGCTAAAGAATGTATTAACATCAAACCACAAGTCGACCGTTACTTGTTGTCTTCTGGTAGACACGTCATCTTGTTGGCTAACGGTAGATTAGTTAACTTGGGTTGTGCTACTGGTCACTCATCTTTCGTTATGTCTTGTTCCTTCTCTAACCAAGTCTTAGCTCAAATTGCTTTGTTCAAGTCTAACGATAAGTCTTTCAGAGAAAAGCACATTGAATTCCAAAAGACAGGCCCATTCGAAGTTGGTGTCCACGTTTTGCCAAAGATCTTGGATGAAGCTGTCGCTAAGTTCCACTTGGGCAACTTGGGTGTTAGATTGACTAAATTGAGTAAAGTCCAATCTGAATACTTGGGTATTCCAGAAGAAGGTCCATTCAAGGCCGACCACTACAGATATTGA","protein_sequence":"MSAPAQNYKIADISLAAFGRKEIELAEHEMPGLMAIRKAYGDVQPLKGARIAGCLHMTIQTAVLIETLVALGAEVTWSSCNIYSTQDHAAAAIAASGVPVFAWKGETEEEYLWCIEQQLFAFKDNKKLNLILDDGGDLTTLVHEKHPEMLEDCFGLSEETTTGVHHLYRMVKEGKLKVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGMGARVLVTEIDPINALQAAMEGYQVVTMEDASHIGQVFVTTTGCRDIINGEHFINMPEDAIVCNIGHFDIEIDVAWLKANAKECINIKPQVDRYLLSSGRHVILLANGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKSNDKSFREKHIEFQKTGPFEVGVHVLPKILDEAVAKFHLGNLGVRLTKLSKVQSEYLGIPEEGPFKADHYRY"},{"created_at":"2011-05-27T17:15:59.000Z","updated_at":"2011-07-22T17:53:59.000Z","name":"Uridine nucleosidase","uniprot_id":"Q04179","uniprot_name":"URH1_YEAST","enzyme":true,"transporter":false,"gene_name":"URH1","num_residues":340,"molecular_weight":"37960.0","theoretical_pi":"5.07","general_function":"Involved in hydrolase activity, hydrolyzing N-glycosyl compounds","specific_function":"Also acts on cytidine","reactions":[{"id":1269,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1609,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2835,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"Uridine + H(2)O = D-ribose + uracil.","export":false,"pw_reaction_id":null,"source":null},{"id":4195,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006494","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"URH1","chromosome_location":"chromosome 4","locus":"YDR400W","synonyms":["Uridine ribohydrolase"],"enzyme_classes":["3.2.2.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on glycosyl bonds"},{"category":"Function","description":" hydrolase activity, hydrolyzing N-glycosyl compounds"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"IU_nuc_hydro","identifier":"PF01156"}],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGACTGTTAGTAAAATACCCATATGGCTAGATTGTGATCCTGGTCATGATGATGCCATAGCCATTTTATTAGGCTGTTTCCATCCAGCTTTCAATCTTCTAGGAATCAGCACGTGTTTTGGTAACGCACCGCCAGAGAATACTGACTACAACGCCCGTTCTCTTTTGACTGCGATGGGCAAAGCACAAGCGATTCCAGTTTATAAAGGCGCACAGAGACCTTGGAAAAGGGAACCTCATTATGCTCCTGACATTCATGGTATATCAGGTTTAGACGGCACTTCTTTGCTACCTAAGCCAACATTTGAGGCAAGAACTGATAAAACGTATATTGAGGCCATTGAAGAGGCGATTCTAGCTAACAATGGAGAGATATCCTTTGTGTCTACTGGTGCACTTACCACATTAGCAACAGTTTTTAGGTGTAAACCATACCTAAAAAAATCTGTCAAATATATTAGCATTATGGGGGGTGGACTCCATGGTCTAGGAAACTGTAACCCAAATCTTTCTGCTGAATTCAACGTTTGGATTGATCCTGACGCAGCGAATTACATATTCCGTGATCCCGATGTAAAGGACAAATGTATAGTAGTTCCTCTAAATTTAACTCACAAGGCCATAGCTACTTACAAGGTTAACGAAATGATATACAACGAAAAGAATAACAGCAAGTTACGAGAATTGTTTTTGGAGCTTTTTCAATTTTTTGCTCATACCTACAAGGATATGCAAGGATTTGAATCGGGCCCACCTATACATGATCCGGTAGCTTTGATGCCGCTTTTGGAATTTTATGGGTGGGATCCATCGTCTGCGGTTGGATTTCGCTACAAGAGAATGGACATATCCTGCATTGATGATGTTTTCAACGAAAACTCAGGGAAAATTATCATTGAAAAAGAATATCCAAATGACAGTGATGTTGGTACAATAATTGGTCTCGATTTGAATATCCAGTACTTTTGGGATCAGATTTTTGAAGCATTAAATAGAGCAGACAAAATGTCAACGATTGGATAA","protein_sequence":"MTVSKIPIWLDCDPGHDDAIAILLGCFHPAFNLLGISTCFGNAPPENTDYNARSLLTAMGKAQAIPVYKGAQRPWKREPHYAPDIHGISGLDGTSLLPKPTFEARTDKTYIEAIEEAILANNGEISFVSTGALTTLATVFRCKPYLKKSVKYISIMGGGLHGLGNCNPNLSAEFNVWIDPDAANYIFRDPDVKDKCIVVPLNLTHKAIATYKVNEMIYNEKNNSKLRELFLELFQFFAHTYKDMQGFESGPPIHDPVALMPLLEFYGWDPSSAVGFRYKRMDISCIDDVFNENSGKIIIEKEYPNDSDVGTIIGLDLNIQYFWDQIFEALNRADKMSTIG"}]}