{"ymdb_id":"YMDB00256","created_at":"2011-05-29T17:59:13.000Z","updated_at":"2016-09-08T18:35:15.000Z","name":"Adenosine phosphosulfate","cas":"485-84-7","state":"Solid","melting_point":"","description":"Adenosine phosphosulfate (APS) is the initial compound formed by the action of ATP sulfurylase (PAPS synthetase) on sulfate ions after sulfate uptake in the sulfate-activation pathway. It is an intermediate in the sulfate reduction pathway. Plants, fungi, and many bacteria reduce inorganic sulfate to sulfide to cover their need for the element. Before the sulfur can be assimilated into biosynthetic pathways it needs to be reduced to hydrogen sulfide. [Biocyc SULFMETII-PWY]","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":null,"chebi_id":"17709","hmdb_id":"HMDB01003","kegg_id":"C00224","pubchem_id":"228","cs_id":"9821","foodb_id":null,"wikipedia_link":"amps","biocyc_id":"APS","iupac":"[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]sulfonic acid","traditional_iupac":"adenosine phosphosulfate","logp":"-5.56531027203623","pka":"2.6138084060306217","alogps_solubility":"3.29e+00 g/l","alogps_logp":"-1.64","alogps_logs":"-2.11","acceptor_count":"12","donor_count":"5","rotatable_bond_count":"6","polar_surface_area":"229.43999999999994","refractivity":"84.06029999999998","polarizability":"35.06803193134003","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"3.9432165992164756","pka_strongest_acidic":"-2.3443566047904136","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["3-phospho-5-adenylyl sulfate","3-phosphoadenosine 5-phosphosulfate","3'-Phospho-5'-adenylyl sulfate","3'-Phosphoadenosine 5'-phosphosulfate","3'-phosphoadenosine-5'-phosphosulfate","3'-Phosphoadenylyl sulfate","3'-phosphoadenylyl-sulfate","5-phosphoadenosine 3-phosphosulfate","Adenosine 5'-phosphosulfate","adenosine 5'-sulphatophosphate","Adenosine Phosphosulfate","Adenosine phosphosulfic acid","adenosine sulfatophosphate","ADENOSINE-5'-PHOSPHOSULFATE","adenylic acid monoanhydride with sulfurate","adenylic acid monoanhydride with sulfuric acid","adenylyl sulfate","adenylyl-sulfate","Adenylylsulfate","AMPS","APS","paps","Phosphoadenosine Phosphosulfate","Phosphoadenosine phosphosulfic acid","phosphoadenosine-5'-phosphosulfate","phosphosulfate","sulfatophosphate"],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":2556364,"citation":"Plateau, P., Fromant, M., Schmitter, J. M., Buhler, J. M., Blanquet, S. (1989). \"Isolation, characterization, and inactivation of the APA1 gene encoding yeast diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase.\" J Bacteriol 171:6437-6445."},{"pubmed_id":197388,"citation":"Masselot, M., Surdin-Kerjan, Y. (1977). \"Methionine biosynthesis in Saccharomyces cerevisiae. II. Gene-enzyme relationships in the sulfate assimilation pathway.\" Mol Gen Genet 154:23-30."},{"pubmed_id":1654509,"citation":"Korch, C., Mountain, H. A., Bystrom, A. S. (1991). \"Cloning, nucleotide sequence, and regulation of MET14, the gene encoding the APS kinase of Saccharomyces cerevisiae.\" Mol Gen Genet 229:96-108."}],"proteins":[{"created_at":"2011-05-24T19:47:46.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Sulfate adenylyltransferase","uniprot_id":"P08536","uniprot_name":"MET3_YEAST","enzyme":true,"transporter":false,"gene_name":"MET3","num_residues":511,"molecular_weight":"57724.0","theoretical_pi":"5.62","general_function":"Involved in sulfate adenylyltransferase (ATP) activity","specific_function":"Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur- containing amino acids","reactions":[{"id":1990,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2272,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + sulfate = diphosphate + adenylyl sulfate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1J70","cellular_location":"Cytoplasm","genbank_gene_id":"AY723835","genbank_protein_id":"51830408","gene_card_id":"MET3","chromosome_location":"chromosome 10","locus":"YJR010W","synonyms":["ATP-sulfurylase","Methionine-requiring protein 3","Sulfate adenylate transferase","SAT"],"enzyme_classes":["2.7.7.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Function","description":" adenylyltransferase activity"},{"category":"Function","description":" sulfate adenylyltransferase activity"},{"category":"Function","description":" sulfate adenylyltransferase (ATP) activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" sulfur metabolic process"},{"category":"Process","description":" sulfate assimilation"}],"pfams":[{"name":"ATP-sulfurylase","identifier":"PF01747"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGCCTGCTCCTCACGGTGGTATTCTACAAGACTTGATTGCTAGAGATGCGTTAAAGAAGAATGAATTGTTATCTGAAGCGCAATCTTCGGACATTTTAGTATGGAACTTGACTCCTAGACAACTATGTGATATTGAATTGATTCTAAATGGTGGGTTTTCTCCTCTGACTGGGTTTTTGAACGAAAACGATTACTCCTCTGTTGTTACAGATTCGAGATTAGCAGACGGCACATTGTGGACCATCCCTATTACATTAGATGTTGATGAAGCATTTGCTAACCAAATTAAACCAGACACAAGAATTGCCCTTTTCCAAGATGATGAAATTCCTATTGCTATACTTACTGTCCAGGATGTTTACAAGCCAAACAAAACTATCGAAGCCGAAAAAGTCTTCAGAGGTGACCCAGAACATCCAGCCATTAGCTATTTATTTAACGTTGCCGGTGATTATTACGTCGGCGGTTCTTTAGAAGCGATTCAATTACCTCAACATTATGACTATCCAGGTTTGCGTAAGACACCTGCCCAACTAAGACTTGAATTCCAATCAAGACAATGGGACCGTGTCGTAGCTTTCCAAACTCGTAATCCAATGCATAGAGCCCACAGGGAGTTGACTGTGAGAGCCGCCAGAGAAGCTAATGCTAAGGTGCTGACCCATCCAGTTGTTGGACTAACCAAACCAGGTGATATAGACCATCACACTCGTGTTCGTGTCTACCAGGAAATTATTAAGCGTTATCCTAATGGTATTGCTTTCTTATCCCTGTTGCCATTAGCAATGAGAATGAGTGGTGATAGAGAAGCCGTATGGCATGCTATTATTAGAAAGAATTATGGTGCCTCCCACTTCATTGTTGGTAGAGACCATGCGGGCCCAGGTAAGAACTCCAAGGGTGTTGATTTCTACGGTCCATACGATGCTCAAGAATTGGTCGAATCCTACAAGCATGAACTGGACATTGAAGTTGTTCCATTCAGAATGGTCACTTATTTGCCAGACGAAGACCGTTATGCTCCAATTGATCAAATTGACACCACAAAGACGAGAACCTTGAACATTTCAGGTACAGAGTTGAGACGCCGTTTAAGAGTTGGTGGTGAGATTCCTGAATGGTTCTCATATCCTGAAGTGGTTAAAATCCTAAGAGAATCCAACCCACCAAGACCAAAACAAGGTTTTTCAATTGTTTTAGGTAATTCATTAACCGTTTCTCGTGAGCAATTATCCATTGCTTTGTTGTCAACATTCTTGCAATTCGGTGGTGGCAGGTATTACAAGATCTTTGAACACAATAATAAGACAGAGTTACTATCTTTGATTCAAGATTTCATTGGTTCTGGTAGTGGACTAATTATTCCAAATCAATGGGAAGATGACAAGGACTCTGTTGTTGGCAAGCAAAACGTTTACTTATTAGATACCTCAAGCTCAGCCGATATTCAGCTAGAGTCAGCGGATGAACCTATTTCACATATTGTACAAAAAGTTGTCCTATTCTTGGAAGACAATGGCTTTTTTGTATTTTAA","protein_sequence":"MPAPHGGILQDLIARDALKKNELLSEAQSSDILVWNLTPRQLCDIELILNGGFSPLTGFLNENDYSSVVTDSRLADGTLWTIPITLDVDEAFANQIKPDTRIALFQDDEIPIAILTVQDVYKPNKTIEAEKVFRGDPEHPAISYLFNVAGDYYVGGSLEAIQLPQHYDYPGLRKTPAQLRLEFQSRQWDRVVAFQTRNPMHRAHRELTVRAAREANAKVLIHPVVGLTKPGDIDHHTRVRVYQEIIKRYPNGIAFLSLLPLAMRMSGDREAVWHAIIRKNYGASHFIVGRDHAGPGKNSKGVDFYGPYDAQELVESYKHELDIEVVPFRMVTYLPDEDRYAPIDQIDTTKTRTLNISGTELRRRLRVGGEIPEWFSYPEVVKILRESNPPRPKQGFSIVLGNSLTVSREQLSIALLSTFLQFGGGRYYKIFEHNNKTELLSLIQDFIGSGSGLIIPNQWEDDKDSVVGKQNVYLLDTSSSADIQLESADEPISHIVQKVVLFLEDNGFFVF"},{"created_at":"2011-05-24T19:49:46.000Z","updated_at":"2011-07-22T17:54:14.000Z","name":"Protein APA1","uniprot_id":"P16550","uniprot_name":"APA1_YEAST","enzyme":true,"transporter":false,"gene_name":"APA1","num_residues":321,"molecular_weight":"36492.19922","theoretical_pi":"4.66","general_function":"Involved in ATP adenylyltransferase activity","specific_function":"Ap4A phosphorylase catabolizes Ap4N nucleotides (where N is A,C,G or U). Additionally this enzyme catalyzes the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulfate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP","reactions":[{"id":1339,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1340,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1991,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2273,"direction":"\u003e","locations":"","altext":"ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2274,"direction":"\u003e","locations":null,"altext":"ADP + sulfate = phosphate + adenylyl sulfate.","export":false,"pw_reaction_id":null,"source":null},{"id":2275,"direction":"\u003e","locations":null,"altext":"Adenylylsulfate + ATP = P(1),P(4)-bis(5'-adenosyl)tetraphosphate + sulfate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M31791","genbank_protein_id":"171064","gene_card_id":"APA1","chromosome_location":"chromosome 3","locus":"YCL050C","synonyms":["5',5'''-P-1,P-4-tetraphosphate phosphorylase","ATP adenylyltransferase","Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase","AP,A phosphorylase","AP-4-A phosphorylase","ADP-sulfurylase"],"enzyme_classes":["2.7.7.53","2.7.7.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" adenylyltransferase activity"},{"category":"Function","description":" ATP adenylyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"ATP_transf","identifier":"PF09830"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"}],"gene_sequence":"ATGAGTATCCCCGCTGACATTGCATCTTTAATTAGTGACAAGTACAAAAGTGCCTTCGATAATGGTAACTTAAAATTTATCCAGACTGAAACAACGAAAACAAAGGACCCAAAAACCAGCATGCCATACTTGATTAGTCACATGCCAAGTCTGATCGAAAAGCCAGAGCGTGGCCAAACTCCAGAAGGAGAGGATCCACTAGGCAAACCTGAGGAAGAATTAACGGTTATCCCAGAATTTGGTGGTGCCGATAACAAAGCGTATAAATTGCTATTAAACAAATTCCCTGTAATCCCTGAACACACTTTATTGGTAACTAACGAATACCAACATCAAACTGATGCCTTGACCCCAACCGATTTATTGACTGCTTATAAGTTGCTGTGTGCCTTGGACAATGAAGAATCCGACAAGAGACACATGGTCTTTTACAATTCTGGTCCAGCCAGTGGTTCTTCATTGGACCACAAACATTTGCAAATTCTGCAAATGCCTGAAAAGTTCGTCACTTTCCAAGATAGACTATGTAATGGTAAAGAACATTTCCTACCAACTTTCAATACTGAACCTTTGCAAGATGCTAAAGTCTCGTTCGCTCATTTTGTCTTGCCAATGCCGGAGTCTGAAGAAACTGTTGATGAAGACCTATTAGCTATGTGTTACATCTCCATATTGCAAAGAGCTTTGACCTTTTTCCAGGACTGGTTGAACGAAAATCCAGAACTAAAGAAATCCTACAATCTTATGTTAACCAAGGAATGGATCTGTGTCGTTCCACGCTCGAAGGCCTTTTCTGATGAAATGAAGATAGGTTTCAACTCCACAGGTTATTGTGGTATGATCTTAACCAAAAATGATGAAGTTTTCTCCAAGATTACTGAAAAACCTGAATTGATTAACGATATCTTATTGGAATGTGGTTTCCCAAACACTTCTGGTCAAAAACCAAACGAATACAACTATTGA","protein_sequence":"MSIPADIASLISDKYKSAFDNGNLKFIQTETTKTKDPKTSMPYLISHMPSLIEKPERGQTPEGEDPLGKPEEELTVIPEFGGADNKAYKLLLNKFPVIPEHTLLVTNEYQHQTDALTPTDLLTAYKLLCALDNEESDKRHMVFYNSGPASGSSLDHKHLQILQMPEKFVTFQDRLCNGKEHFLPTFNTEPLQDAKVSFAHFVLPMPESEETVDEDLLAMCYISILQRALTFFQDWLNENPELKKSYNLMLTKEWICVVPRSKAFSDEMKIGFNSTGYCGMILTKNDEVFSKITEKPELINDILLECGFPNTSGQKPNEYNY"},{"created_at":"2011-05-26T20:15:50.000Z","updated_at":"2011-07-22T17:54:01.000Z","name":"Adenylyl-sulfate kinase","uniprot_id":"Q02196","uniprot_name":"KAPS_YEAST","enzyme":true,"transporter":false,"gene_name":"MET14","num_residues":202,"molecular_weight":"23060.09961","theoretical_pi":"8.31","general_function":"Involved in ATP binding","specific_function":"Catalyzes the synthesis of activated sulfate","reactions":[{"id":1282,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2591,"direction":"\u003e","locations":null,"altext":"ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate.","export":false,"pw_reaction_id":null,"source":null},{"id":14417,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006930","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY558261","genbank_protein_id":"45270412","gene_card_id":"MET14","chromosome_location":"chromosome 11","locus":"YKL001C","synonyms":["ATP adenosine-5'-phosphosulfate 3'-phosphotransferase","Adenosine-5'-phosphosulfate kinase","APS kinase"],"enzyme_classes":["2.7.1.25"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Process","description":" sulfur metabolic process"},{"category":"Process","description":" sulfate assimilation"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"APS_kinase","identifier":"PF01583"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGGCTACTAATATTACTTGGCATCCAAATCTTACTTACGACGAACGCAAGGCATTGAGAAAACAGGACGGTTGTACTATTTGGTTAACAGGTCTAAGTGCGTCAGGTAAAAGTACAATCGCCTGTGCGCTAGAACAGTTACTGCTCCAAAAAAACTTGTCTGCATATAGATTGGATGGTGACAACATTCGTTTTGGATTGAACAAGGATTTGGGTTTCTCAGAAAAGGACAGAAATGAAAACATTCGTAGAATTAGCGAAGTTTCTAAGCTATTTGCTGATTCATGTGCTATTTCAATCACCTCATTTATCTCTCCATACAGAGTTGACAGAGATAGAGCTCGTGAACTACATAAGGAGGCTGGTTTGAAGTTCATTGAAATATTTGTTGATGTTCCATTAGAAGTCGCTGAGCAAAGGGACCCTAAGGGTTTATACAAGAAAGCTAGGGAGGGTGTAATCAAGGAGTTTACAGGTATTTCTGCCCCATATGAAGCGCCAAAAGCTCCAGAGCTACATTTGAGAACCGACCAGAAGACGGTTGAAGAATGTGCTACCATTATTTATGAGTACTTAATCAGTGAAAAAATCATCCGTAAGCATTTGTAA","protein_sequence":"MATNITWHPNLTYDERKALRKQDGCTIWLTGLSASGKSTIACALEQLLLQKNLSAYRLDGDNIRFGLNKDLGFSEKDRNENIRRISEVSKLFADSCAISITSFISPYRVDRDRARELHKEAGLKFIEIFVDVPLEVAEQRDPKGLYKKAREGVIKEFTGISAPYEAPKAPELHLRTDQKTVEECATIIYEYLISEKIIRKHL"},{"created_at":"2016-09-09T22:38:32.000Z","updated_at":"2016-09-09T22:38:33.000Z","name":"Eukaryotic peptide chain release factor GTP-binding subunit","uniprot_id":"P05453","uniprot_name":"SUP35","enzyme":false,"transporter":false,"gene_name":"SUP35","num_residues":685,"molecular_weight":"76550.76","theoretical_pi":null,"general_function":"translational termination","specific_function":"Involved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides. Recruited by polyadenylate-binding protein PAB1 to poly(A)-tails of mRNAs. Interaction with PAB1 is also required for regulation of normal mRNA decay through translation termination-coupled poly(A) shortening.","reactions":[{"id":14416,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006929","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":null,"pdb_id":"1YJO","cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["ERF-3","ERF2","G1 to S phase transition protein 1","Omnipotent suppressor protein 2","PSI no more protein 2","Polypeptide release factor 3","Translation release factor 3","ERF3"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"cytosol"},{"category":"Function","description":"cytoplasmic stress granule"},{"category":"Function","description":"translation release factor complex"},{"category":"Function","description":"GTP binding"},{"category":"Function","description":"GTPase activity"},{"category":"Function","description":"translation release factor activity"},{"category":"Function","description":"cytoplasmic translational termination"},{"category":"Function","description":"nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"},{"category":"Function","description":"translational termination"}],"pfams":[],"pathways":[{"name":"Sulfur metabolism","kegg_map_id":"00920"}],"gene_sequence":"ATGTCGGATTCAAACCAAGGCAACAATCAGCAAAACTACCAGCAATACAGCCAGAACGGTAACCAACAACAAGGTAACAACAGATACCAAGGTTATCAAGCTTACAATGCTCAAGCCCAACCTGCAGGTGGGTACTACCAAAATTACCAAGGTTATTCTGGGTACCAACAAGGTGGCTATCAACAGTACAATCCCGACGCCGGTTACCAGCAACAGTATAATCCTCAAGGAGGCTATCAACAGTACAATCCTCAAGGCGGTTATCAGCAGCAATTCAATCCACAAGGTGGCCGTGGAAATTACAAAAACTTCAACTACAATAACAATTTGCAAGGATATCAAGCTGGTTTCCAACCACAGTCTCAAGGTATGTCTTTGAACGACTTTCAAAAGCAACAAAAGCAGGCCGCTCCCAAACCAAAGAAGACTTTGAAGCTTGTCTCCAGTTCCGGTATCAAGTTGGCCAATGCTACCAAGAAGGTTGGCACAAAACCTGCCGAATCTGATAAGAAAGAGGAAGAGAAGTCTGCTGAAACCAAAGAACCAACTAAAGAGCCAACAAAGGTCGAAGAACCAGTTAAAAAGGAGGAGAAACCAGTCCAGACTGAAGAAAAGACGGAGGAAAAATCGGAACTTCCAAAGGTAGAAGACCTTAAAATCTCTGAATCAACACATAATACCAACAATGCCAATGTTACCAGTGCTGATGCCTTGATCAAGGAACAGGAAGAAGAAGTGGATGACGAAGTTGTTAACGATATGTTTGGTGGTAAAGATCACGTTTCTTTAATTTTCATGGGTCATGTTGATGCCGGTAAATCTACTATGGGTGGTAATCTACTATACTTGACTGGCTCTGTGGATAAGAGAACTATTGAGAAATATGAAAGAGAAGCCAAGGATGCAGGCAGACAAGGTTGGTACTTGTCATGGGTCATGGATACCAACAAAGAAGAAAGAAATGATGGTAAGACTATCGAAGTTGGTAAGGCCTACTTTGAAACTGAAAAAAGGCGTTATACCATATTGGATGCTCCTGGTCATAAAATGTACGTTTCCGAGATGATCGGTGGTGCTTCTCAAGCTGATGTTGGTGTTTTGGTCATTTCCGCCAGAAAGGGTGAGTACGAAACCGGTTTTGAGAGAGGTGGTCAAACTCGTGAACACGCCCTATTGGCCAAGACCCAAGGTGTTAATAAGATGGTTGTCGTCGTAAATAAGATGGATGACCCAACCGTTAACTGGTCTAAGGAACGTTACGACCAATGTGTGAGTAATGTCAGCAATTTCTTGAGAGCAATTGGTTACAACATTAAGACAGACGTTGTATTTATGCCAGTATCCGGCTACAGTGGTGCAAATTTGAAAGATCACGTAGATCCAAAAGAATGCCCATGGTACACCGGCCCAACTCTGTTAGAATATCTGGATACAATGAACCACGTCGACCGTCACATCAATGCTCCATTCATGTTGCCTATTGCCGCTAAGATGAAGGATCTAGGTACCATCGTTGAAGGTAAAATTGAATCCGGTCATATCAAAAAGGGTCAATCCACCCTACTGATGCCTAACAAAACCGCTGTGGAAATTCAAAATATTTACAACGAAACTGAAAATGAAGTTGATATGGCTATGTGTGGTGAGCAAGTTAAACTAAGAATCAAAGGTGTTGAAGAAGAAGACATTTCACCAGGTTTTGTACTAACATCGCCAAAGAACCCTATCAAGAGTGTTACCAAGTTTGTAGCTCAAATTGCTATTGTAGAATTAAAATCTATCATAGCAGCCGGTTTTTCATGTGTTATGCATGTTCATACAGCAATTGAAGAGGTACATATTGTTAAGTTATTGCACAAATTAGAAAAGGGTACCAACCGTAAGTCAAAGAAACCACCTGCTTTTGCTAAGAAGGGTATGAAGGTCATCGCTGTTTTAGAAACTGAAGCTCCAGTTTGTGTGGAAACTTACCAAGATTACCCTCAATTAGGTAGATTCACTTTGAGAGATCAAGGTACCACAATAGCAATTGGTAAAATTGTTAAAATTGCCGAGTAA","protein_sequence":"MSDSNQGNNQQNYQQYSQNGNQQQGNNRYQGYQAYNAQAQPAGGYYQNYQGYSGYQQGGYQQYNPDAGYQQQYNPQGGYQQYNPQGGYQQQFNPQGGRGNYKNFNYNNNLQGYQAGFQPQSQGMSLNDFQKQQKQAAPKPKKTLKLVSSSGIKLANATKKVGTKPAESDKKEEEKSAETKEPTKEPTKVEEPVKKEEKPVQTEEKTEEKSELPKVEDLKISESTHNTNNANVTSADALIKEQEEEVDDEVVNDMFGGKDHVSLIFMGHVDAGKSTMGGNLLYLTGSVDKRTIEKYEREAKDAGRQGWYLSWVMDTNKEERNDGKTIEVGKAYFETEKRRYTILDAPGHKMYVSEMIGGASQADVGVLVISARKGEYETGFERGGQTREHALLAKTQGVNKMVVVVNKMDDPTVNWSKERYDQCVSNVSNFLRAIGYNIKTDVVFMPVSGYSGANLKDHVDPKECPWYTGPTLLEYLDTMNHVDRHINAPFMLPIAAKMKDLGTIVEGKIESGHIKKGQSTLLMPNKTAVEIQNIYNETENEVDMAMCGEQVKLRIKGVEEEDISPGFVLTSPKNPIKSVTKFVAQIAIVELKSIIAAGFSCVMHVHTAIEEVHIVKLLHKLEKGTNRKSKKPPAFAKKGMKVIAVLETEAPVCVETYQDYPQLGRFTLRDQGTTIAIGKIVKIAE"}]}