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Identification |
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Name | Cystathionine beta-lyase |
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Synonyms | - CBL
- Beta-cystathionase
- Cysteine lyase
- Sulfur transfer protein 3
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Gene Name | STR3 |
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Enzyme Class | |
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Biological Properties |
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General Function | Involved in pyridoxal phosphate binding |
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Specific Function | L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate |
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Cellular Location | Cytoplasm. Nucleus |
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SMPDB Pathways | |
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KEGG Pathways | |
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SMPDB Reactions | |
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KEGG Reactions | |
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Metabolites | YMDB ID | Name | View |
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YMDB00091 | Ammonia | Show | YMDB00175 | Pyruvic acid | Show | YMDB00245 | L-Cystathionine | Show | YMDB00371 | Homocysteine | Show | YMDB00423 | Ammonium | Show | YMDB00520 | L-Homocysteine | Show | YMDB00890 | water | Show | YMDB16178 | Selenohomocysteine | Show | YMDB16184 | Selenocystathionine | Show |
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GO Classification | Component |
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Not Available | Function |
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binding | cofactor binding | pyridoxal phosphate binding | carbon-sulfur lyase activity | cystathionine beta-lyase activity | catalytic activity | lyase activity | Process |
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cellular amino acid metabolic process | sulfur amino acid metabolic process | sulfur amino acid biosynthetic process | methionine biosynthetic process | L-methionine biosynthetic process | 'de novo' L-methionine biosynthetic process | metabolic process | cellular metabolic process | cellular amino acid and derivative metabolic process |
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Gene Properties |
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Chromosome Location | chromosome 7 |
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Locus | YGL184C |
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Gene Sequence | >1398 bp
ATGCCGATCAAGAGATTAGATACAGTTGTGGTAAATACCGGCTCTCAAAATGACCAACAT
TCAGCCTCCGTGCCACCGGTGTATTTGTCGACTACCTTCAAAGTGGACTTGAATAATGAA
GATGCACAGAACTACGATTATTCCAGATCGGGAAACCCGACCAGAAGTGTCCTTCAACAC
CAGATTGGTAAGCTTTATCGTGTCCCACAGGAAAACGTATTAGCTGTGAGCAGTGGTATG
ACGGCGCTAGACGTCATCCTGCGTGGGCTCGTCTTACTTAACGGCACTGACAACCATACG
CCAACAATAATAGCCGGCGATGATCTTTATGGAGGCACCCAAAGGCTGCTGAATTTTTTC
AAGCAACAGAGTCATGCAGTCTCTGTTCATGTGGACACTTCCGATTTTGAAAAGTTCAAA
ACCGTTTTCCAGTCTTTAGATAAAGTTGATTGTGTTCTTCTAGAGTCTCCGACCAATCCG
CTTTGCAAGGTTGTAGATATCCCTAGAATATTACGTTTTGTGAAATGCATATCTCCCGAC
ACTACAGTTGTCGTTGATAATACTATGATGAGTGGACTCAATTGTAATCCTCTTCAACTG
AATCCAGGCTGCGATGTCGTATACGAATCTGCTACCAAGTACTTGAATGGTCATCACGAT
TTGATGGGGGGTGTTATTATCAGCAAAACACCAGAAATAGCCTCGAAGCTTTACTTTGTC
ATTAATTCTACAGGAGCTGGATTATCCCCAATGGATTCTTGGCTACTTGTGAGGGGCCTA
AAAACTCTAGGAGTTAGATTATATCAACAGCAGAGAAATGCTATGATATTGGCTCATTGG
CTAGAAAATTCATGCGGATTCAAACCTACCAGAACAAACAAGGCTACGAAAACTAGATTT
GTTGGATTACGCTCCAACCCGGATTTCAAGCTGCATAAATCGTTCAATAATGGCCCAGGT
GCCGTGTTATCCTTCGAAACGGGGTCCTTCGAACATTCAAAGAGACTGGTCAGTTCCAAA
AAACTGAGTATATGGGCTGTGACGGTATCTTTCGGGTGTGTAAATTCGCTTCTATCTATG
CCTTGCAAAATGTCCCATGCTTCCATTGATCCCGAATTAAGGAAAGAGAGAGATTTTCCT
GAAGATTTGGTTCGTCTTTGCTGCGGTATCGAAAATATAGTAGATTTGAAGAAAGATTTA
TTAGCGGCGATGGTTGACGCTGATATTATAGAAGTAAGAGAAAATGGCAAATATCTTTTC
AACAAATTGAATAAGAACCTAGCTGTGAACACTACCATCGATGACCTGCATAAGCCTTTA
AGTATTTACGAAGAATTTTACAATCAAGATCTCATCAGAAAGGACTCAGAATTGAATATT
AAGAGTTCGAAATTGTAA |
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Protein Properties |
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Pfam Domain Function | |
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Protein Residues | 465 |
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Protein Molecular Weight | 51828.0 |
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Protein Theoretical pI | 8.1 |
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Signalling Regions | |
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Transmembrane Regions | |
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Protein Sequence | >Cystathionine beta-lyase
MPIKRLDTVVVNTGSQNDQHSASVPPVYLSTTFKVDLNNEDAQNYDYSRSGNPTRSVLQH
QIGKLYRVPQENVLAVSSGMTALDVILRGLVLLNGTDNHTPTIIAGDDLYGGTQRLLNFF
KQQSHAVSVHVDTSDFEKFKTVFQSLDKVDCVLLESPTNPLCKVVDIPRILRFVKCISPD
TTVVVDNTMMSGLNCNPLQLNPGCDVVYESATKYLNGHHDLMGGVIISKTPEIASKLYFV
INSTGAGLSPMDSWLLVRGLKTLGVRLYQQQRNAMILAHWLENSCGFKPTRTNKATKTRF
VGLRSNPDFKLHKSFNNGPGAVLSFETGSFEHSKRLVSSKKLSIWAVTVSFGCVNSLLSM
PCKMSHASIDPELRKERDFPEDLVRLCCGIENIVDLKKDLLAAMVDADIIEVRENGKYLF
NKLNKNLAVNTTIDDLHKPLSIYEEFYNQDLIRKDSELNIKSSKL |
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References |
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External Links | |
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General Reference | - Coglievina, M., Klima, R., Bertani, I., Delneri, D., Zaccaria, P., Bruschi, C. V. (1997). "Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae." Yeast 13:55-64.9046087
- Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
- Hansen, J., Johannesen, P. F. (2000). "Cysteine is essential for transcriptional regulation of the sulfur assimilation genes in Saccharomyces cerevisiae." Mol Gen Genet 263:535-542.10821189
- Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
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