L-Cysteine (YMDB00046)

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Identification

YMDB ID

YMDB00046

Name

L-Cysteine

Species

Saccharomyces cerevisiae

Strain

Baker's yeast

Description

Cysteine (abbreviated as Cys or C) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a nonpolar amino acid. The side chain on cysteine is thiol, which is considered nonpolar. The thiol side chain often participates in enzymatic reactions, serving as a nucleophile. The thiol is susceptible to oxidization to give the disulfide derivative cystine, which serves an important structural role in many proteins. Cysteine biosynthesis starts from serine, which is converted to O-acetylserine by the enzyme serine transacetylase. The enzyme O-acetylserine (thiol)-lyase, using sulfide sources, converts this ester into cysteine, releasing acetate. Cysteine, mainly the L-enantiomer, is a precursor in the food, pharmaceutical, and personal care industries. One of the largest applications is the production of flavors. For example, the reaction of cysteine with sugars in a Maillard reaction yields meat flavors. L-cysteine is also used as a processing aid for baking.

Structure

MOL SDF PDB SMILES InChI

Synonyms

(+)-2-Amino-3-mercaptopropionic acid
(2R)-2-amino-3-mercaptopropanoate
(2R)-2-amino-3-mercaptopropanoic acid
(2R)-2-amino-3-sulfanylpropanoate
(2R)-2-amino-3-sulfanylpropanoic acid
(2R)-2-amino-3-Sulphanylpropanoate
(2R)-2-amino-3-Sulphanylpropanoic acid
(R)-(+)-cysteine
(R)-2-amino-3-mercapto-Propanoate
(R)-2-amino-3-mercapto-Propanoic acid
(R)-2-Amino-3-mercaptopropanoate
(R)-2-Amino-3-mercaptopropanoic acid
(R)-cysteine
2-Amino-3-mercaptopropanoate
2-Amino-3-mercaptopropanoic acid
2-Amino-3-mercaptopropionate
2-Amino-3-mercaptopropionic acid
3-mercapto-L-Alanine
acetylcysteine
alpha-amino-beta-thiolpropionic acid
B-mercaptoalanine
beta-mercaptoalanine
C
Carbocysteine
Cisteina
Cisteinum
Cys
Cystein
Cysteine
Cysteine hydrochloride
Cysteinum
e 920
e-920
e920
Free cysteine
Half cystine
Half-cystine
L cysteine
L-(+)-cysteine
L-2-Amino-3-mercaptopropanoate
L-2-Amino-3-mercaptopropanoic acid
L-2-amino-3-Mercaptopropionate
L-2-Amino-3-mercaptopropionic acid
L-cystein
L-cysteine
L-Zystein
Polycysteine
Thioserine
Zinc cysteinate
Ecolan

CAS number

52-90-4

Weight

Average: 121.158
Monoisotopic: 121.019749163

InChI Key

XUJNEKJLAYXESH-REOHCLBHSA-N

InChI

InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1

IUPAC Name

(2R)-2-amino-3-sulfanylpropanoic acid

Traditional IUPAC Name

L-cysteine

Chemical Formula

C₃H₇NO₂S

SMILES

[H]OC(=O)[C@@]([H])(N([H])[H])C([H])([H])S[H]

Chemical Taxonomy

Description

belongs to the class of organic compounds known as cysteine and derivatives. Cysteine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Cysteine and derivatives

Alternative Parents

Substituents

Cysteine or derivatives
Alpha-amino acid
L-alpha-amino acid
Amino acid
Alkylthiol
Carboxylic acid
Monocarboxylic acid or derivatives
Organic oxygen compound
Primary amine
Organosulfur compound
Organooxygen compound
Organonitrogen compound
Organic nitrogen compound
Primary aliphatic amine
Carbonyl group
Amine
Hydrocarbon derivative
Organopnictogen compound
Organic oxide
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

proteinogenic amino acid (CHEBI:17561 )
L-alpha-amino acid (CHEBI:17561 )
cysteine (CHEBI:17561 )
serine family amino acid (CHEBI:17561 )
Common amino acids (C00097 )

Physical Properties

State

Solid

Charge

Melting point

220 °C

Experimental Properties

Property	Value	Reference
Water Solubility	277 mg/mL at 25 oC [BEILSTEIN]	PhysProp
LogP	-2.49 [HANSCH,C ET AL. (1995)]	PhysProp

Predicted Properties

Property	Value	Source
Water Solubility	23.1 g/L	ALOGPS
logP	-2.6	ALOGPS
logP	-2.8	ChemAxon
logS	-0.72	ALOGPS
pKa (Strongest Acidic)	2.35	ChemAxon
pKa (Strongest Basic)	9.05	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	63.32 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	28.22 m³·mol⁻¹	ChemAxon
Polarizability	11.41 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Biological Properties

Cellular Locations

extracellular
cytoplasm

Organoleptic Properties

Flavour/Odour	Source
Sulfury	FDB012678

SMPDB Pathways

Cysteine Metabolism	PW002383
Glutathione metabolism	PW002395
Pantothenate and CoA biosynthesis	PW002463
Sulfur metabolism	PW002483
beta-Alanine metabolism	PW002381

KEGG Pathways

Cysteine and methionine metabolism	ec00270
Glutathione metabolism	ec00480
Glycine, serine and threonine metabolism	ec00260
Pantothenate and CoA biosynthesis	ec00770
Sulfur metabolism	ec00920

SMPDB Reactions

L-Cysteine + an [L-cysteine desulfurase] L-cysteine persulfide → an [L-cysteine desulfurase] L-cysteine persulfide + L-Alanine

D-4'-Phosphopantothenate + Cytidine triphosphate + L-Cysteine → Cytidine monophosphate + Pyrophosphate + hydron + 4-Phosphopantothenoylcysteine

water + L-Cystathionine → Ammonium + L-Cysteine + 2-Ketobutyric acid

L-Cysteine → Hydrogen sulfide + hydron + 2-aminoprop-2-enoate

L-Glutamic acid + L-Cysteine + Adenosine triphosphate → ADP + phosphate + hydron + Gamma-Glutamylcysteine

KEGG Reactions

L-Cystathionine + water → L-Cysteine + Ammonium + 2-Ketobutyric acid

L-Cysteine + O-Acetyl-L-homoserine → Acetic acid + L-Cystathionine + hydron

O-acetyl-L-serine + Hydrogen sulfide → Acetic acid + hydron + L-Cysteine

Adenosine triphosphate + tRNA(Cys) + L-Cysteine → Adenosine monophosphate + Pyrophosphate + Cys-tRNA(Cys)

Adenosine triphosphate + L-Glutamic acid + L-Cysteine → phosphate + Gamma-Glutamylcysteine + hydron + ADP

Concentrations

Intracellular Concentrations

Not Available

Extracellular Concentrations

Not Available

Spectra

Spectrum Type	Description	Splash Key	View
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (4 TMS)	splash10-00kb-0950000000-df7e91c95b610ff21c79	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (4 TMS)	splash10-00kb-0940000000-aefe34765fb447090a23	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (4 TMS)	splash10-00kb-0970000000-10a155c40ea499023052	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (Non-derivatized)	splash10-00kb-0940000000-037a3a34651c3154b3b3	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (4 TMS)	splash10-00di-9850000000-118c43e33861a6baa8d2	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-014j-0690100000-0aeb88fd507505e6b718	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00kb-0950000000-df7e91c95b610ff21c79	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00kb-0940000000-aefe34765fb447090a23	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00kb-0970000000-10a155c40ea499023052	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00kb-0940000000-037a3a34651c3154b3b3	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - GC-EI-QQ (Non-derivatized)	splash10-0uk9-5619100000-8cb2558373966174ced3	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00di-9850000000-118c43e33861a6baa8d2	JSpectraViewer \| MoNA
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-0gi0-0960000000-03b2097de6f9637d29cb	JSpectraViewer \| MoNA
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-004l-9100000000-4553906a941a5e87ec97	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positive	splash10-004i-9200000000-cfaf705cd0452d428454	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_2) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_3) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_1) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_2) - 70eV, Positive	Not Available	JSpectraViewer
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_3) - 70eV, Positive	Not Available	JSpectraViewer
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-00b9-9600000000-374c5872d68662832769	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0a4i-9000000000-ddbd3df6b8dbb280ffba	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0a4i-9000000000-320a2c77443b80ebf733	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0089-0900000000-9dcd3d757c5cd11eb18e	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udi-3900000000-212e081fe83ad70de0ad	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-2eb01f41c225f614db24	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-a19834eb7cb9f211fdf2	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-0900000000-2458f2587761e779ed93	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-9000000000-77e590f0ed26f69b31c0	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udi-3900000000-7b1857997392b006b95f	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-3900000000-bc268c27ed5706a4bbd2	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - CE-ESI-TOF (CE-system connected to 6210 Time-of-Flight MS, Agilent) , Positive	splash10-00di-0900000000-4573390bccc238e3c91b	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , positive	splash10-0udi-3900000000-212e081fe83ad70de0ad	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , positive	splash10-0udi-3900000000-7b1857997392b006b95f	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - QqQ 14V, negative	splash10-001i-9000000000-5dc69d3b59bd15290aef	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - 10V, Positive	splash10-0a6r-9100000000-ed3c9c47ed98679090ab	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - 0V, Positive	splash10-00di-2900000000-8bb219d17ccdf7ac0a5d	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - 30V, Positive	splash10-0a4i-9000000000-e623d5a27b5075c82b4d	JSpectraViewer \| MoNA
LC-MS/MS	LC-MS/MS Spectrum - 10V, Positive	splash10-056r-9100000000-4e26cc13af7c878115f7	JSpectraViewer \| MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00b9-9600000000-4352a7b437c34c04d9f0	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-004i-9200000000-7b4cd034c717561c61dd	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-052f-9000000000-8f351cbca6ffed356a9b	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-00di-6900000000-51ba0df80cc33423420b	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0079-9400000000-4aa2b707c391d5838d29	JSpectraViewer
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-001i-9000000000-95c7672c7836c0fc51c9	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
1D NMR	1H NMR Spectrum	Not Available	JSpectraViewer
1D NMR	13C NMR Spectrum	Not Available	JSpectraViewer
2D NMR	[1H,1H] 2D NMR Spectrum	Not Available	JSpectraViewer
2D NMR	[1H,13C] 2D NMR Spectrum	Not Available	JSpectraViewer

References

References:

UniProt Consortium (2011). "Ongoing and future developments at the Universal Protein Resource." Nucleic Acids Res 39:D214-D219.21051339
Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). "BRENDA, the enzyme information system in 2011." Nucleic Acids Res 39:D670-D676.21062828
Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology." Nat Biotechnol 26:1155-1160.18846089
Ono, B., Shirahige, Y., Nanjoh, A., Andou, N., Ohue, H., Ishino-Arao, Y. (1988). "Cysteine biosynthesis in Saccharomyces cerevisiae: mutation that confers cystathionine beta-synthase deficiency." J Bacteriol 170:5883-5889.3056921
Schreve, J. L., Sin, J. K., Garrett, J. M. (1998). "The Saccharomyces cerevisiae YCC5 (YCL025c) gene encodes an amino acid permease, Agp1, which transports asparagine and glutamine." J Bacteriol 180:2556-2559.9573211
Nookaew, I., Jewett, M. C., Meechai, A., Thammarongtham, C., Laoteng, K., Cheevadhanarak, S., Nielsen, J., Bhumiratana, S. (2008). "The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism." BMC Syst Biol 2:71.18687109
Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). "Growth control of the eukaryote cell: a systems biology study in yeast." J Biol 6:4.17439666

Synthesis Reference:

Kumagai, Hidehiko; Tanaka, Hideyuki; Sejima, Shunsuke; Yamada, Hideaki. Elimination and replacement reactions of b-chloro-L-alanine by cysteine desulfhydrase from Aerobacter aerogenes. Agricultural and Biological Chemistry (1977), 41(10), 2071-5.

External Links:

Resource	Link
CHEBI ID	17561
HMDB ID	HMDB00574
Pubchem Compound ID	5862
Kegg ID	C00097
ChemSpider ID	5653
FOODB ID	FDB012678
Wikipedia	Cysteine
BioCyc ID	CYS

Enzymes

Protein Details

1. Cysteine desulfurase, mitochondrial

General function:: Involved in metabolic process
Specific function:: Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. Involved in both tRNA-processing and mitochondrial metabolism
Gene Name:: NFS1
Uniprot ID:: P25374
Molecular weight:: 54466.5

Reactions

L-cysteine + [enzyme]-cysteine → L-alanine + [enzyme]-S-sulfanylcysteine.

Protein Details

2. Putative cysteine synthase

General function:: Involved in cysteine biosynthetic process from serine
Specific function:: O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate
Gene Name:: Not Available
Uniprot ID:: P53206
Molecular weight:: 42800.5

Reactions

O(3)-acetyl-L-serine + H(2)S → L-cysteine + acetate.

Protein Details

3. Putative cystathionine gamma-synthase YML082W

General function:: Involved in pyridoxal phosphate binding
Specific function:: O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate
Gene Name:: Not Available
Uniprot ID:: Q04533
Molecular weight:: 74312.70313

Reactions

O(4)-succinyl-L-homoserine + L-cysteine → L-cystathionine + succinate.

Protein Details

4. Protein MET17

General function:: Involved in pyridoxal phosphate binding
Specific function:: Transforms O-acetylhomoserine into homocysteine and O- acetylserine into cysteine
Gene Name:: MET17
Uniprot ID:: P06106
Molecular weight:: 48671.39844

Reactions

O-acetyl-L-homoserine + methanethiol → L-methionine + acetate.
O(3)-acetyl-L-serine + H(2)S → L-cysteine + acetate.

Protein Details

5. Cystathionine gamma-lyase

General function:: Involved in pyridoxal phosphate binding
Specific function:: L-cystathionine + H(2)O = L-cysteine + NH(3) + 2-oxobutanoate
Gene Name:: CYS3
Uniprot ID:: P31373
Molecular weight:: 42541.69922

Reactions

L-cystathionine + H(2)O → L-cysteine + NH(3) + 2-oxobutanoate.

Protein Details

6. Uncharacterized protein YIL083C

General function:: Coenzyme transport and metabolism
Specific function:: Not Available
Gene Name:: Not Available
Uniprot ID:: P40506
Molecular weight:: 41892.69922

Reactions

CTP + (R)-4'-phosphopantothenate + L-cysteine → CMP + PPi + N-((R)-4'-phosphopantothenoyl)-L-cysteine.

Protein Details

7. Glutamate--cysteine ligase

General function:: Involved in glutamate-cysteine ligase activity
Specific function:: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
Gene Name:: GSH1
Uniprot ID:: P32477
Molecular weight:: 78252.89844

Reactions

ATP + L-glutamate + L-cysteine → ADP + phosphate + gamma-L-glutamyl-L-cysteine.

Protein Details

8. Putative cystathionine gamma-synthase YLL058W

General function:: Involved in pyridoxal phosphate binding
Specific function:: O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate
Gene Name:: Not Available
Uniprot ID:: Q12198
Molecular weight:: 64222.80078

Reactions

O(4)-succinyl-L-homoserine + L-cysteine → L-cystathionine + succinate.

Protein Details

9. Cysteinyl-tRNA synthetase

General function:: Involved in nucleotide binding
Specific function:: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)
Gene Name:: Not Available
Uniprot ID:: P53852
Molecular weight:: 87529.5

Reactions

ATP + L-cysteine + tRNA(Cys) → AMP + diphosphate + L-cysteinyl-tRNA(Cys).

Protein Details

10. Cystathionine gamma-synthase

General function:: Involved in pyridoxal phosphate binding
Specific function:: O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate
Gene Name:: STR2
Uniprot ID:: P47164
Molecular weight:: 72349.89844

Reactions

O(4)-succinyl-L-homoserine + L-cysteine → L-cystathionine + succinate.

Protein Details

11. Gamma-glutamyltransferase

General function:: Involved in gamma-glutamyltransferase activity
Specific function:: Plays a role in the turnover of the vacuolar glutathione and in the supply of growth requirements during nitrogen starvation
Gene Name:: ECM38
Uniprot ID:: Q05902
Molecular weight:: 73179.79688

Reactions

(5-L-glutamyl)-peptide + an amino acid → peptide + 5-L-glutamyl amino acid.

Transporters

Protein Details

1. General amino-acid permease GAP1

General function:: Involved in transport
Specific function:: Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine
Gene Name:: GAP1
Uniprot ID:: P19145
Molecular weight:: 65654.89844

Protein Details

2. High-affinity glutamine permease

General function:: Involved in transport
Specific function:: High affinity transport of glutamine. Also transport Leu, Ser, Thr, Cys, Met and Asn
Gene Name:: GNP1
Uniprot ID:: P48813
Molecular weight:: 73597.39844

Protein Details

3. Tryptophan permease

General function:: Involved in transport
Specific function:: Required for high-affinity tryptophan transport. Also transports cysteine, phenyalanine and tyrosine
Gene Name:: TAT2
Uniprot ID:: P38967
Molecular weight:: 65403.80078

Protein Details

4. Leu/Val/Ile amino-acid permease

General function:: Involved in transport
Specific function:: Permease for leucine, valine and isoleucine. Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan
Gene Name:: BAP2
Uniprot ID:: P38084
Molecular weight:: 67669.60156

Protein Details

5. Valine/tyrosine/tryptophan amino-acid permease 1

General function:: Involved in transport
Specific function:: High-affinity transport of valine and tyrosine. Low- affinity transport of tryptophan. Can also transport L-cysteine
Gene Name:: TAT1
Uniprot ID:: P38085
Molecular weight:: 68756.89844

Protein Details

6. Valine amino-acid permease

General function:: Involved in transport
Specific function:: Involved in transport of isoleucine, leucine, valine, cysteine, methionine, phenylalanine, tyrosine and tryptophan
Gene Name:: BAP3
Uniprot ID:: P41815
Molecular weight:: 67364.39844

Protein Details

7. General amino acid permease AGP1

General function:: Involved in transport
Specific function:: Broad substrate range permease which transports asparagine and glutamine with intermediate specificity. Also transports Ala, Cys, Gly, Ile, Leu, Met, Phe, Ser, Thr, Tyr and Val. Important for the utilization of amino acids as a nitrogen source
Gene Name:: AGP1
Uniprot ID:: P25376
Molecular weight:: 69670.70313

Structure for #<Compound:0xae56c738>

Enzymes

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Transporters