{"ymdb_id":"YMDB00160","created_at":"2011-05-29T16:02:36.000Z","updated_at":"2016-10-18T17:11:19.000Z","name":"Glutathione","cas":"70-18-8","state":"Solid","melting_point":"195 oC","description":"Glutathione (GSH) is a tripeptide that contains an unusual peptide linkage between the amine group of cysteine and the carboxyl group of the glutamate side-chain. It is an antioxidant and a coenzyme in various enzymatic reactions. Glutathione exists in reduced (GSH) and oxidized (GSSG) states. Glutathione is found almost exclusively in its reduced form, since the enzyme that reverts it from its oxidized form, glutathione reductase, is constitutively active and inducible upon oxidative stress.","experimental_water_solubility":"292.5 mg/mL [HMP experimental]","experimental_logp_hydrophobicity":"","location":"extracellular;mitochondrion;vacuole;cytoplasm","synthesis_reference":null,"chebi_id":"16856","hmdb_id":"HMDB00125","kegg_id":"C00051","pubchem_id":"124886","cs_id":"111188","foodb_id":null,"wikipedia_link":"Glutathione","biocyc_id":"OXIDIZED-GLUTATHIONE","iupac":"(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid","traditional_iupac":"glutathione","logp":"-4.88467621618675","pka":"3.737311352465548","alogps_solubility":"8.79e-01 g/l","alogps_logp":"-2.74","alogps_logs":"-2.54","acceptor_count":"7","donor_count":"6","rotatable_bond_count":"9","polar_surface_area":"158.82000000000002","refractivity":"69.11490000000002","polarizability":"29.11283212542198","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"9.223740958320658","pka_strongest_acidic":"1.9364037247697885","bioavailability":"1","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["5-L-Glutamyl-L-cysteinylglycine","Agifutol S","Bakezyme RX","Copren","Deltathione","gamma-Glutamylcysteinylglycine","gamma-L-glutamyl-L-cysteinyl-glycine","gamma-L-Glutamyl-L-cysteinylglycine","Glutathion","Glutathione","Glutathione red","Glutathione reduced","Glutathione-SH","Glutatiol","Glutatione","Glutide","Glutinal","GSH","Isethion","L-g-glutamyl-L-cysteinyl-glycine","L-gamma-glutamyl-L-cysteinyl-glycine","L-gamma-glutamyl-L-cysteinylglycine","L-glutamyl-L-cysteinylglycine","L-Glutathione","L-Glutathione reduce","Ledac","Neuthion","red. glutathione","Reduced glutathione","Tathion","Tathione","Triptide"],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Pyruvate metabolism","kegg_map_id":"00620"}],"growth_conditions":[{"growth_media":"YM medium","concentration":"354.6757","concentration_units":"\u0026#181;M","error":"296.1054"},{"growth_media":"YPD medium/SC medium","concentration":"2112.736","concentration_units":"\u0026#181;M","error":"41.024"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":8662189,"citation":"Grant, C. M., MacIver, F. H., Dawes, I. W. (1996). \"Glutathione is an essential metabolite required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae.\" Curr Genet 29:511-515."},{"pubmed_id":9202464,"citation":"Mehdi, K., Penninckx, M. J. (1997). \"An important role for glutathione and gamma-glutamyltranspeptidase in the supply of growth requirements during nitrogen starvation of the yeast Saccharomyces cerevisiae.\" Microbiology 143 ( Pt 6):1885-1889."},{"pubmed_id":6102906,"citation":"Penninckx, M., Jaspers, C., Wiame, J. M. (1980). \"Glutathione metabolism in relation to the amino-acid permeation systems of the yeast Saccharomyces cerevisiae. Occurrence of gamma-glutamyltranspeptidase: its regulation and the effects of permeation mutations on the enzyme cellular level.\" Eur J Biochem 104:119-123."},{"pubmed_id":14672937,"citation":"Outten, C. E., Culotta, V. C. (2004). \"Alternative start sites in the Saccharomyces cerevisiae GLR1 gene are responsible for mitochondrial and cytosolic isoforms of glutathione reductase.\" J Biol Chem 279:7785-7791."},{"pubmed_id":9729482,"citation":"Rebbeor, J. F., Connolly, G. C., Dumont, M. E., Ballatori, N. (1998). \"ATP-dependent transport of reduced glutathione in yeast secretory vesicles.\" Biochem J 334 ( Pt 3):723-729."},{"pubmed_id":3908097,"citation":"Inoue, Y., Watanabe, K., Shimosaka, M., Saikusa, T., Fukuda, Y., Murata, K., Kimura, A. (1985). \"Metabolism of 2-oxoaldehydes in yeasts. Purification and characterization of lactaldehyde dehydrogenase from Saccharomyces cerevisiae.\" Eur J Biochem 153:243-247."},{"pubmed_id":15357293,"citation":"Cha, J. Y., Park, J. C., Jeon, B. S., Lee, Y. C., Cho, Y. S. (2004). \"Optimal fermentation conditions for enhanced glutathione production by Saccharomyces cerevisiae FF-8.\" J Microbiol 42:51-55."},{"pubmed_id":15277542,"citation":"Ostergaard, H., Tachibana, C., Winther, J. R. (2004). \"Monitoring disulfide bond formation in the eukaryotic cytosol.\" J Cell Biol 166:337-345."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T19:11:10.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"Glutathione peroxidase 2","uniprot_id":"P38143","uniprot_name":"GPX2_YEAST","enzyme":true,"transporter":false,"gene_name":"GPX2","num_residues":162,"molecular_weight":"18406.0","theoretical_pi":"8.84","general_function":"Involved in glutathione peroxidase activity","specific_function":"May constitute a glutathione peroxidase-like protective system against oxidative stresses","reactions":[{"id":1584,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2240,"direction":"\u003e","locations":"","altext":"2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":2241,"direction":"\u003e","locations":"Cytoplasm","altext":"2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + H2O","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY557641","genbank_protein_id":"45269175","gene_card_id":"GPX2","chromosome_location":"chromosome 2","locus":"YBR244W","synonyms":[],"enzyme_classes":["1.11.1.9","1.11.1.12"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" antioxidant activity"},{"category":"Function","description":" peroxidase activity"},{"category":"Function","description":" glutathione peroxidase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" response to stimulus"},{"category":"Process","description":" response to stress"},{"category":"Process","description":" response to oxidative stress"}],"pfams":[{"name":"GSHPx","identifier":"PF00255"}],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Arachidonic acid metabolism","kegg_map_id":"00590"}],"gene_sequence":"ATGACCACATCTTTTTATGATTTAGAATGCAAGGACAAGAAAGGCGAATCTTTTAAGTTTGACCAACTGAAAGGCAAAGTAGTTCTCATAGTTAATGTTGCCTCCAAGTGCGGCTTCACGCCGCAGTATAAAGAATTGGAAGAACTATACAAAAAATATCAAGATAAGGGGTTTGTTATTTTGGGGTTCCCATGTAATCAGTTCGGGAAGCAGGAACCGGGCTCTGATGAACAAATTACGGAATTTTGCCAGTTGAATTATGGCGTTACATTCCCAATTATGAAGAAGATTGATGTTAACGGAAGTAATGCTGACTCTGTCTATAATTATTTGAAAAGCCAAAAAGCAGGTTTACTAGGTTTCAAGGGTATCAAATGGAATTTTGAAAAGTTCTTAGTTGATTCCAATGGTAAGGTTGTCCAAAGATTTTCCTCCTTAACAAAACCATCGTCCTTGGACCAAGAAATCCAAAGCCTGTTAAGTAAATGA","protein_sequence":"MTTSFYDLECKDKKGESFKFDQLKGKVVLIVNVASKCGFTPQYKELEELYKKYQDKGFVILGFPCNQFGKQEPGSDEQITEFCQLNYGVTFPIMKKIDVNGSNADSVYNYLKSQKAGLLGFKGIKWNFEKFLVDSNGKVVQRFSSLTKPSSLDQEIQSLLSK"},{"created_at":"2011-05-24T20:05:04.000Z","updated_at":"2011-05-27T14:55:59.000Z","name":"Glutathione synthetase","uniprot_id":"Q08220","uniprot_name":"GSHB_YEAST","enzyme":true,"transporter":false,"gene_name":"GSH2","num_residues":491,"molecular_weight":"55814.69922","theoretical_pi":"5.32","general_function":"Involved in ATP binding","specific_function":"ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione","reactions":[{"id":1585,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2297,"direction":"\u003e","locations":null,"altext":"ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.","export":false,"pw_reaction_id":null,"source":null},{"id":3830,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006355","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1M0W","cellular_location":null,"genbank_gene_id":"AY723864","genbank_protein_id":"51830516","gene_card_id":"GSH2","chromosome_location":"chromosome 15","locus":"YOL049W","synonyms":["GSH synthetase","GSH-S","Glutathione synthase"],"enzyme_classes":["6.3.2.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" ligase activity"},{"category":"Function","description":" ligase activity, forming carbon-nitrogen bonds"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" acid-amino acid ligase activity"},{"category":"Function","description":" glutathione synthase activity"},{"category":"Process","description":" glutathione biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" peptide metabolic process"},{"category":"Process","description":" glutathione metabolic process"}],"pfams":[{"name":"GSH_synth_ATP","identifier":"PF03917"},{"name":"GSH_synthase","identifier":"PF03199"}],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGGCACACTATCCACCTTCCAAGGATCAATTGAATGAATTGATCCAGGAAGTTAACCAATGGGCTATCACTAATGGATTATCCATGTATCCTCCTAAATTCGAGGAGAACCCATCAAATGCATCGGTGTCACCAGTAACTATCTATCCAACCCCAATTCCTAGGAAATGTTTTGATGAGGCCGTTCAAATACAACCGGTATTCAATGAATTATACGCCCGTATTACCCAAGATATGGCCCAACCTGATTCTTATTTACATAAAACAACTGAAGCGTTAGCTCTATCAGATTCCGAGTTTACTGGAAAACTGTGGTCTCTATACCTTGCTACCTTAAAATCTGCACAGTACAAAAAGCAGAATTTTAGGCTAGGTATATTTAGATCAGATTATTTGATTGATAAGAAAAAGGGTACTGAACAGATTAAGCAAGTCGAGTTTAATACAGTGTCAGTGTCATTTGCAGGCCTTAGCGAGAAAGTTGATAGATTGCACTCTTATTTAAATAGGGCAAACAAGTACGATCCTAAAGGACCAATTTATAATGATCAAAATATGGTCATTTCTGATTCAGGATACCTTTTGTCTAAGGCATTGGCCAAAGCTGTGGAATCGTATAAGTCACAACAAAGTTCTTCTACAACTAGTGATCCTATTGTCGCATTCATTGTGCAAAGAAACGAGAGAAATGTGTTTGATCAAAAGGTCTTGGAATTGAATCTGTTGGAAAAATTCGGTACCAAATCTGTTAGGTTGACGTTTGATGATGTTAACGATAAATTGTTCATTGATGATAAAACGGGAAAGCTTTTCATTAGGGACACAGAGCAGGAAATAGCGGTGGTTTATTACAGAACGGGTTACACAACCACTGATTACACGTCCGAAAAGGACTGGGAGGCAAGACTATTCCTCGAAAAAAGTTTCGCAATAAAGGCCCCAGATTTACTCACTCAATTATCTGGCTCCAAGAAAATTCAGCAATTGTTGACAGATGAGGGCGTATTAGGTAAATACATCTCCGATGCTGAGAAAAAGAGTAGTTTGTTAAAAACTTTTGTCAAAATATATCCCTTGGATGATACGAAGCTTGGCAGGGAAGGCAAGAGGCTGGCATTAAGTGAGCCCTCTAAATACGTGTTAAAACCACAGCGGGAAGGTGGCGGAAACAATGTTTATAAAGAAAATATTCCTAATTTTTTGAAAGGTATCGAAGAACGTCACTGGGATGCATATATTCTCATGGAGTTGATTGAACCAGAGTTGAATGAAAATAATATTATATTACGTGATAACAAATCTTACAACGAACCAATCATCAGTGAACTAGGAATTTATGGTTGCGTTCTATTTAACGACGAGCAAGTTTTATCGAACGAATTTAGTGGCTCATTACTAAGATCCAAATTTAATACTTCAAATGAAGGTGGAGTGGCGGCAGGATTCGGATGTTTGGACAGTATTATTCTTTACTAG","protein_sequence":"MAHYPPSKDQLNELIQEVNQWAITNGLSMYPPKFEENPSNASVSPVTIYPTPIPRKCFDEAVQIQPVFNELYARITQDMAQPDSYLHKTTEALALSDSEFTGKLWSLYLATLKSAQYKKQNFRLGIFRSDYLIDKKKGTEQIKQVEFNTVSVSFAGLSEKVDRLHSYLNRANKYDPKGPIYNDQNMVISDSGYLLSKALAKAVESYKSQQSSSTTSDPIVAFIVQRNERNVFDQKVLELNLLEKFGTKSVRLTFDDVNDKLFIDDKTGKLFIRDTEQEIAVVYYRTGYTTTDYTSEKDWEARLFLEKSFAIKAPDLLTQLSGSKKIQQLLTDEGVLGKYISDAEKKSSLLKTFVKIYPLDDTKLGREGKRLALSEPSKYVLKPQREGGGNNVYKENIPNFLKGIEERHWDAYILMELIEPELNENNIILRDNKSYNEPIISELGIYGCVLFNDEQVLSNEFSGSLLRSKFNTSNEGGVAAGFGCLDSIILY"},{"created_at":"2011-05-24T20:25:28.000Z","updated_at":"2011-07-22T17:54:08.000Z","name":"S-(hydroxymethyl)glutathione dehydrogenase","uniprot_id":"P32771","uniprot_name":"FADH_YEAST","enzyme":true,"transporter":false,"gene_name":"SFA1","num_residues":386,"molecular_weight":"41041.69922","theoretical_pi":"6.76","general_function":"Involved in zinc ion binding","specific_function":"Oxidizes long-chain alcohols and, in the presence of glutathione, is able to oxidize formaldehyde. Is responsible for yeast resistance to formaldehyde","reactions":[{"id":1291,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1294,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1296,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1303,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1305,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1308,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1545,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2317,"direction":"\u003e","locations":null,"altext":"S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null},{"id":2314,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm;Mitochondrion","altext":"An alcohol + NAD(+) = an aldehyde or ketone + NADH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X68020","genbank_protein_id":"288591","gene_card_id":"SFA1","chromosome_location":"chromosome 4","locus":"YDL168W","synonyms":["Alcohol dehydrogenase SFA","Glutathione-dependent formaldehyde dehydrogenase","FALDH","FDH","FLD","GSH-FDH"],"enzyme_classes":["1.1.1.284","1.1.1.1","1.1.1.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" S-(hydroxymethyl)glutathione dehydrogenase activity"},{"category":"Process","description":" monohydric alcohol metabolic process"},{"category":"Process","description":" ethanol metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" ethanol oxidation"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"}],"pfams":[{"name":"ADH_N","identifier":"PF08240"},{"name":"ADH_zinc_N","identifier":"PF00107"}],"pathways":[{"name":"Methane metabolism","kegg_map_id":"00680"}],"gene_sequence":"ATGTCCGCCGCTACTGTTGGTAAACCTATTAAGTGCATTGCTGCTGTTGCGTATGATGCGAAGAAACCATTAAGTGTTGAAGAAATCACGGTAGACGCCCCAAAAGCGCACGAAGTACGTATCAAAATTGAATATACTGCTGTATGCCACACTGATGCGTACACTTTATCAGGCTCTGATCCAGAAGGACTTTTCCCTTGCGTTCTGGGCCACGAAGGAGCCGGTATCGTAGAATCTGTAGGCGATGATGTCATAACAGTTAAGCCTGGTGATCATGTTATTGCTTTGTACACTGCTGAGTGTGGCAAATGTAAGTTCTGTACTTCCGGTAAAACCAACTTATGTGGTGCTGTTAGAGCTACTCAAGGGAAAGGTGTAATGCCTGATGGGACCACAAGATTTCATAATGCGAAAGGTGAAGATATATACCATTTCATGGGTTGCTCTACTTTTTCCGAATATACTGTGGTGGCAGATGTCTCTGTGGTTGCCATCGATCCAAAAGCTCCCTTGGATGCTGCCTGTTTACTGGGTTGTGGTGTTACTACTGGTTTTGGGGCGGCTCTTAAGACAGCTAATGTGCAAAAAGGCGATACCGTTGCAGTATTTGGCTGCGGGACTGTAGGACTCTCCGTTATCCAAGGTGCAAAGTTAAGGGGCGCTTCCAAGATCATTGCCATTGACATTAACAATAAGAAAAAACAATATTGTTCTCAATTTGGTGCCACGGATTTTGTTAATCCCAAGGAAGATTTGGCCAAAGATCAAACTATCGTTGAAAAGTTAATTGAAATGACTGATGGGGGTCTGGATTTTACTTTTGACTGTACTGGTAATACCAAAATTATGAGAGATGCTTTGGAAGCCTGTCATAAAGGTTGGGGTCAATCTATTATCATTGGTGTGGCTGCCGCTGGTGAAGAAATTTCTACAAGGCCGTTCCAGCTGGTCACTGGTAGAGTGTGGAAAGGCTCTGCTTTTGGTGGCATCAAAGGTAGATCTGAAATGGGCGGTTTAATTAAAGACTATCAAAAAGGTGCCTTAAAAGTCGAAGAATTTATCACTCACAGGAGACCATTCAAAGAAATCAATCAAGCCTTTGAAGATTTGCATAACGGTGATTGCTTAAGAACCGTCTTGAAGTCTGATGAAATAAAATAG","protein_sequence":"MSAATVGKPIKCIAAVAYDAKKPLSVEEITVDAPKAHEVRIKIEYTAVCHTDAYTLSGSDPEGLFPCVLGHEGAGIVESVGDDVITVKPGDHVIALYTAECGKCKFCTSGKTNLCGAVRATQGKGVMPDGTTRFHNAKGEDIYHFMGCSTFSEYTVVADVSVVAIDPKAPLDAACLLGCGVTTGFGAALKTANVQKGDTVAVFGCGTVGLSVIQGAKLRGASKIIAIDINNKKKQYCSQFGATDFVNPKEDLAKDQTIVEKLIEMTDGGLDFTFDCTGNTKIMRDALEACHKGWGQSIIIGVAAAGEEISTRPFQLVTGRVWKGSAFGGIKGRSEMGGLIKDYQKGALKVEEFITHRRPFKEINQAFEDLHNGDCLRTVLKSDEIK"},{"created_at":"2011-05-26T16:47:52.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Glutathione reductase","uniprot_id":"P41921","uniprot_name":"GSHR_YEAST","enzyme":true,"transporter":false,"gene_name":"GLR1","num_residues":483,"molecular_weight":"53440.60156","theoretical_pi":"7.96","general_function":"Involved in oxidoreductase activity","specific_function":"Maintains high levels of reduced glutathione in the cytosol","reactions":[{"id":2445,"direction":"\u003e","locations":"Cytoplasm","altext":"2 glutathione + NADP(+) = glutathione disulfide + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":3693,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003279","source":"Smpdb"},{"id":3694,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006559","source":"Smpdb"},{"id":3695,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006560","source":"Smpdb"},{"id":3696,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006561","source":"Smpdb"},{"id":3699,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003282","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U43281","genbank_protein_id":"1151235","gene_card_id":"GLR1","chromosome_location":"chromosome 16","locus":"YPL091W","synonyms":["GR","GRase"],"enzyme_classes":["1.8.1.7"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" NADP or NADPH binding"},{"category":"Function","description":" binding"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" disulfide oxidoreductase activity"},{"category":"Function","description":" peptide disulfide oxidoreductase activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" glutathione disulfide oxidoreductase activity"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" glutathione-disulfide reductase activity"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cell redox homeostasis"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" peptide metabolic process"},{"category":"Process","description":" glutathione metabolic process"}],"pfams":[{"name":"Pyr_redox","identifier":"PF00070"},{"name":"Pyr_redox_2","identifier":"PF07992"},{"name":"Pyr_redox_dim","identifier":"PF02852"}],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"Pyruvate metabolism","kegg_map_id":"00620"},{"name":"TCA Cycle","kegg_map_id":null}],"gene_sequence":"ATGCTTTCTGCAACCAAACAAACATTTAGAAGTCTACAGATAAGAACTATGTCCACGAACACCAAGCATTACGATTACCTCGTCATCGGGGGTGGCTCAGGGGGTGTTGCTTCCGCAAGAAGAGCTGCATCTTATGGTGCGAAGACATTACTAGTTGAAGCTAAGGCTCTTGGTGGTACCTGTGTTAACGTGGGTTGTGTTCCGAAGAAAGTCATGTGGTATGCTTCTGACCTCGCTACTAGAGTATCCCATGCAAATGAATATGGATTATATCAGAATCTTCCATTAGATAAAGAGCATTTGACTTTTAATTGGCCAGAATTTAAGCAGAAAAGGGATGCTTATGTCCATAGGTTGAACGGTATATACCAGAAGAATTTAGAAAAAGAAAAAGTGGATGTTGTATTTGGATGGGCTAGATTCAATAAGGACGGTAATGTTGAAGTTCAGAAAAGGGATAATACTACTGAAGTTTACTCCGCTAACCATATTTTAGTTGCGACCGGTGGAAAGGCTATTTTCCCCGAAAACATTCCAGGTTTCGAATTAGGTACTGATTCTGATGGGTTCTTTAGATTGGAAGAACAACCTAAGAAAGTTGTTGTTGTTGGCGCTGGTTATATTGGTATTGAGCTAGCAGGTGTGTTCCATGGGCTGGGATCCGAAACGCACTTGGTAATTAGAGGTGAAACTGTCTTGAGAAAATTTGATGAATGCATCCAGAACACTATTACTGACCATTACGTAAAGGAAGGCATCAACGTTCATAAACTATCCAAAATTGTTAAGGTGGAGAAAAATGTAGAAACTGACAAACTGAAAATACATATGAATGACTCAAAGTCCATCGATGACGTTGACGAATTAATTTGGACAATTGGACGTAAATCCCATCTAGGTATGGGTTCAGAAAATGTAGGTATAAAGCTGAACTCTCATGACCAAATAATTGCTGATGAATATCAGAACACCAATGTTCCAAACATTTATTCTCTAGGTGACGTTGTTGGAAAAGTTGAATTGACACCTGTCGCTATTGCAGCGGGCAGAAAGCTGTCTAATAGACTGTTTGGTCCAGAGAAATTCCGTAATGACAAACTAGATTACGAGAACGTCCCCAGCGTAATTTTCTCACATCCTGAAGCCGGTTCCATTGGTATTTCTGAGAAGGAAGCCATTGAAAAGTACGGTAAGGAGAATATAAAGGTCTACAATTCCAAATTTACCGCCATGTACTATGCTATGTTGAGTGAGAAATCACCCACAAGATATAAAATTGTTTGTGCGGGACCAAATGAAAAGGTTGTCGGTCTGCACATTGTTGGTGATTCCTCTGCAGAAATCTTGCAAGGGTTCGGTGTTGCTATAAAGATGGGTGCCACTAAGGCTGATTTCGATAATTGTGTTGCTATTCATCCGACTAGCGCAGAAGAATTGGTTACTATGAGATGA","protein_sequence":"MLSATKQTFRSLQIRTMSTNTKHYDYLVIGGGSGGVASARRAASYGAKTLLVEAKALGGTCVNVGCVPKKVMWYASDLATRVSHANEYGLYQNLPLDKEHLTFNWPEFKQKRDAYVHRLNGIYQKNLEKEKVDVVFGWARFNKDGNVEVQKRDNTTEVYSANHILVATGGKAIFPENIPGFELGTDSDGFFRLEEQPKKVVVVGAGYIGIELAGVFHGLGSETHLVIRGETVLRKFDECIQNTITDHYVKEGINVHKLSKIVKVEKNVETDKLKIHMNDSKSIDDVDELIWTIGRKSHLGMGSENVGIKLNSHDQIIADEYQNTNVPNIYSLGDVVGKVELTPVAIAAGRKLSNRLFGPEKFRNDKLDYENVPSVIFSHPEAGSIGISEKEAIEKYGKENIKVYNSKFTAMYYAMLSEKSPTRYKIVCAGPNEKVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAEELVTMR"},{"created_at":"2011-05-26T16:48:31.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Glutathione peroxidase 1","uniprot_id":"P36014","uniprot_name":"GPX1_YEAST","enzyme":true,"transporter":false,"gene_name":"GPX1","num_residues":167,"molecular_weight":"19484.5","theoretical_pi":"8.57","general_function":"Involved in glutathione peroxidase activity","specific_function":"May constitute a glutathione peroxidase-like protective system against oxidative stresses","reactions":[{"id":1584,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2240,"direction":"\u003e","locations":"","altext":"2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":2241,"direction":"\u003e","locations":"Cytoplasm","altext":"2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + H2O","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY557895","genbank_protein_id":"45269681","gene_card_id":"GPX1","chromosome_location":"chromosome 11","locus":"YKL026C","synonyms":[],"enzyme_classes":["1.11.1.9","1.11.1.12"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" antioxidant activity"},{"category":"Function","description":" peroxidase activity"},{"category":"Function","description":" glutathione peroxidase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" response to stimulus"},{"category":"Process","description":" response to stress"},{"category":"Process","description":" response to oxidative stress"}],"pfams":[{"name":"GSHPx","identifier":"PF00255"}],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Arachidonic acid metabolism","kegg_map_id":"00590"}],"gene_sequence":"ATGCAAGAATTTTATTCTTTTTCACCAATAGATGAAAACGGAAATCCATTCCCCTTCAACTCCCTGCGTAACAAAGTGGTTTTGATAGTCAATGTAGCATCTCATTGTGCGTTCACACCTCAATACAAGGAATTAGAGTACTTGTACGAAAAATACAAATCACATGGTCTAGTGATTGTGGCCTTTCCCTGTGGTCAATTCGGAAATCAAGAGTTCGAGAAGGATAAAGAGATTAATAAGTTCTGTCAAGATAAATATGGTGTAACCTTCCCTATTCTACATAAGATCCGTTGCAACGGGCAAAAGCAAGATCCCGTCTACAAGTTCTTAAAGAATTCAGTAAGCGGGAAGTCTGGAATAAAAATGATAAAATGGAATTTTGAAAAGTTTGTGGTAGACCGAAATGGGAAGGTGGTTAAAAGGTTTTCATGCATGACTAGGCCACTAGAGCTTTGTCCAATAATCGAAGAATTACTGAATCAACCACCAGAAGAACAGATTTAA","protein_sequence":"MQEFYSFSPIDENGNPFPFNSLRNKVVLIVNVASHCAFTPQYKELEYLYEKYKSHGLVIVAFPCGQFGNQEFEKDKEINKFCQDKYGVTFPILHKIRCNGQKQDPVYKFLKNSVSGKSGIKMIKWNFEKFVVDRNGKVVKRFSCMTRPLELCPIIEELLNQPPEEQI"},{"created_at":"2011-05-27T02:50:50.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"Gamma-glutamyltransferase","uniprot_id":"Q05902","uniprot_name":"ECM38_YEAST","enzyme":true,"transporter":false,"gene_name":"ECM38","num_residues":660,"molecular_weight":"73179.79688","theoretical_pi":"5.72","general_function":"Involved in gamma-glutamyltransferase activity","specific_function":"Plays a role in the turnover of the vacuolar glutathione and in the supply of growth requirements during nitrogen starvation","reactions":[{"id":1557,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2696,"direction":"\u003e","locations":"Vacuole membrane; Single-pass type II membrane protein","altext":"(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.","export":false,"pw_reaction_id":null,"source":null},{"id":3831,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006356","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"14-34","pdb_id":null,"cellular_location":"Vacuole membrane; Single-pass type II membrane protein","genbank_gene_id":"U17243","genbank_protein_id":"596034","gene_card_id":"ECM38","chromosome_location":"chromosome 12","locus":"YLR299W","synonyms":["CIK1 suppressor protein 2","Extracellular mutant protein 38","Gamma-glutamyltranspeptidase","Gamma-GT","Gamma-glutamyltransferase heavy chain","Gamma-glutamyltransferase light chain"],"enzyme_classes":["2.3.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring amino-acyl groups"},{"category":"Function","description":" gamma-glutamyltransferase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"G_glu_transpept","identifier":"PF01019"}],"pathways":[{"name":"Taurine and hypotaurine metabolism","kegg_map_id":"00430"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Cyanoamino acid metabolism","kegg_map_id":"00460"},{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Arachidonic acid metabolism","kegg_map_id":"00590"}],"gene_sequence":"ATGCTGTTGTGTAATAGAAAAGTCCCCAAGACTTTAAATACCTGTTTTATACTGCATATATTCACTCTGTTAACACTGGGTGTGTTAGTGTCCGGAATGCCGTCAAAAATGGTATCATTCGCCTCTCAGGAGACTTTGCAGAGAATAAATAATCTCCTTCGAGGGTCTGCCAATCGAGATGTTGACATTATTGCAGAATATTTGAAAAAAGACGACGATGATGATGGCGGCGATAAGGATCACCATAACATCGATATTGACCCTTTACCTCGCCGTCCTAGTTTAACGCCTGATAGGCAACTTCTAAAAGTCGGTTTGCATGGTGCTATAAGTTCAGATTTAGAAGTCTGTAGTAATTTGACTATAAATGAGGTACTCCTGAAATTTCCCGGTTCTAACGCTGCAGACGCTGCAGTAACACAAGCTCTTTGTAAGGGTATGGTGAATTTTTTTAATAGTGGGATTGGAGGTGGTGGCTACGTAGTTTTTTCTGGCAAAGACGATGAAGATCATCTATCCATTGATTTTAGAGAAAAAGCACCCATGGATTCACATAAGTTCATGTTCGAAAACTGCTCTCTATGCTCAAAAATAGGGGGTCTTGCTGTCGGTGTTCCAGGTGAATTGATGGGTCTCTATCGCCTCTTTAAAGAAAGAGGTAGCGGCCAAGTTGATTGGCGTGATCTAATTGAACCAGTCGCAAAGCTGGGAAGCGTGGGTTGGCAAATAGGCGAAGCACTCGGTGCCACTTTAGAACTTTATGAGGATGTTTTCCTGACATTGAAGGAAGATTGGTCGTTTGTATTGAATTCTACCCATGACGGTGTTTTGAAAGAAGGCGATTGGATCAAGAGGCCGGCACTATCTAACATGCTAATGGAACTGGCTAAAAATGGTTCCGTGGCCCCATTTTATGACCCCGATCACTGGATTGCAAAATCCATGATTGATACTGTCGCAAAATACAATGGAATAATGAACTTGCAGGATGTTTCATCGTATGATGTTCATGTTACTAAACCACTGTCCATGAAAATTAGGAAGGGCGCCAATTTCATCCCTGATAACGATATGACCGTATTAACAAGTAGCGGCTCAAGTTCCGGGGCTGCACTACTTGCGGCGTTAAGGATAATGGATAATTTCCAGAATCAAGAAGGGGGCGATTATGAAAAAGAAACTACCTATCATTTGCTTGAAAGCATGAAATGGATGGCAAGCGCAAGAAGCAGGTTAGGCGATTTTGAAGGCGAAGCATTACCTAAGCATATAGAAGAGGTATTGGATCCAGAATGGGCTTTGAAAGCAGTGAAATCAATCAAAAGAAACTCTCAAGACGGAAATTTTAAAACTTTAGAAAACTGGACGCTTTATGATCCGGCATACGATATCAATAACCCGCATGGAACTGCCCACTTCAGTATAGTAGATTCACATGGGAATGCTGTTTCCTTGACAACCACCATCAACTTGTTGTTCGGTTCCTTAGTACACGACCCAAAAACCGGGGTGATCTTCAATAATGAAATGGACGATTTCGCTCAATTCAACAAATCTAATAGTTTTGAATTGGCACCCTCCATATACAACTTTCCCGAGCCCGGGAAAAGACCCCTATCATCCACTGCACCCACTATTGTGCTGTCAGAATTAGGCATCCCAGACCTCGTGGTCGGCGCTTCCGGCGGCTCAAGAATCACTACGAGTGTTTTACAAACAATTGTGAGGACGTACTGGTATAACATGCCTATATTGGAAACGATAGCCTATCCACGTATACACCACCAGTTACTGCCCGACCGCATAGAACTGGAAAGCTTCCCCATGATCGGTAAAGCCGTACTAAGCACTCTCAAGGAAATGGGATATACGATGAAAGAAGTATTTCCCAAGAGCGTAGTTAATGCTATACGCAATGTCAGGGGAGAATGGCATGCGGTGAGTGACTATTGGAGAAAAAGAGGAATCTCCTCCGTATACTAA","protein_sequence":"MLLCNRKVPKTLNTCFILHIFTLLTLGVLVSGMPSKMVSFASQETLQRINNLLRGSANRDVDIIAEYLKKDDDDDGGDKDHHNIDIDPLPRRPSLTPDRQLLKVGLHGAISSDLEVCSNLTINEVLLKFPGSNAADAAVTQALCKGMVNFFNSGIGGGGYVVFSGKDDEDHLSIDFREKAPMDSHKFMFENCSLCSKIGGLAVGVPGELMGLYRLFKERGSGQVDWRDLIEPVAKLGSVGWQIGEALGATLELYEDVFLTLKEDWSFVLNSTHDGVLKEGDWIKRPALSNMLMELAKNGSVAPFYDPDHWIAKSMIDTVAKYNGIMNLQDVSSYDVHVTKPLSMKIRKGANFIPDNDMTVLTSSGSSSGAALLAALRIMDNFQNQEGGDYEKETTYHLLESMKWMASARSRLGDFEGEALPKHIEEVLDPEWALKAVKSIKRNSQDGNFKTLENWTLYDPAYDINNPHGTAHFSIVDSHGNAVSLTTTINLLFGSLVHDPKTGVIFNNEMDDFAQFNKSNSFELAPSIYNFPEPGKRPLSSTAPTIVLSELGIPDLVVGASGGSRITTSVLQTIVRTYWYNMPILETIAYPRIHHQLLPDRIELESFPMIGKAVLSTLKEMGYTMKEVFPKSVVNAIRNVRGEWHAVSDYWRKRGISSVY"},{"created_at":"2011-05-27T02:53:19.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"Glutathione S-transferase omega-like 2","uniprot_id":"P36156","uniprot_name":"GTO2_YEAST","enzyme":true,"transporter":false,"gene_name":"ECM4","num_residues":370,"molecular_weight":"43273.39844","theoretical_pi":"6.89","general_function":"Posttranslational modification, protein turnover, chaperones","specific_function":"Active as '1-Cys' thiol transferase against beta- hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis","reactions":[{"id":2699,"direction":"\u003e","locations":"Peroxisome;Cytoplasm;Endoplasmic reticulum membrane; Peripheral membrane protein","altext":"RX + glutathione = HX + R-S-glutathione.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"Z28301","genbank_protein_id":"486551","gene_card_id":"ECM4","chromosome_location":"chromosome 11","locus":"YKR076W","synonyms":["Extracellular mutant protein 4"],"enzyme_classes":["2.5.1.18"],"go_classes":[],"pfams":[],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGTCGAAACAGTGGGCGAGTGGTACAAACGGAGCTTTCAAAAGACAGGTTTCGTCCTTCAGAGAAACAATCTCTAAGCAACACCCAATTTATAAGCCAGCAAAGGGAAGATATTGGTTGTATGTTTCACTTGCATGCCCATGGGCCCATAGAACACTAATTACGAGGGCTTTGAAGGGATTAACCTCTGTTATAGGATGTAGCGTAGTCCATTGGCACCTTGACGAGAAAGGATGGAGATTTTTGGACATGGAAAAGCAATTGGAGGACAGTGAAGATTTTTTGGAACATTGGCACGATGTTGCAGGTGGTATTAGAACTGCTAAAGAGGATTCCAGCAAGAGCTTCGCCGAGATCAAGAATGACAGTCAAAGATTCATGGTTGATGCTACCAATGAGCCTCACTATGGATACAAGAGAATCAGTGACTTATATTACAAGAGCGATCCTCAATACTCGGCAAGGTTCACCGTCCCAGTCCTGTGGGACTTAGAAACCCAAACAATTGTTAACAACGAAAGTAGCGAAATTATAAGGATTTTGAACTCTAGTGCGTTCGATGAATTTGTCGACGACGATCACAAGAAAACGGACCTTGTTCCTGCTCAGTTGAAAACACAGATCGATGACTTCAATTCTTGGGTTTACGACAGCATCAACAATGGTGTATACAAGACCGGATTCGCAGAGAAAGCAGAAGTTTACGAAAGTGAAGTCAACAACGTATTTGAACATTTGGACAAAGTGGAGAAAATCCTGAGTGACAAATATTCCAAATTGAAGGCCAAATACGGTGAAGAAGATAGACAAAAAATCTTGGGTGAGTTCTTCACTGTGGGTGATCAATTAACAGAAGCTGACATTAGATTGTATACTACCGTCATAAGATTCGATCCTGTGTACGTCCAACATTTCAAATGCAATTTTACCTCTATTAGAGCCGGATATCCATTTATTCATTTGTGGGTAAGAAATTTATACTGGAATTATGATGCCTTCAGGTACACAACAGATTTTGACCATATCAAGTTACACTACACGCGTTCCCACACAAGGATCAACCCCTTGGGAATTACGCCCCTGGGACCCAAGCCAGATATTCGTCCTTTATAA","protein_sequence":"MSKQWASGTNGAFKRQVSSFRETISKQHPIYKPAKGRYWLYVSLACPWAHRTLITRALKGLTSVIGCSVVHWHLDEKGWRFLDMEKQLEDSEDFLEHWHDVAGGIRTAKEDSSKSFAEIKNDSQRFMVDATNEPHYGYKRISDLYYKSDPQYSARFTVPVLWDLETQTIVNNESSEIIRILNSSAFDEFVDDDHKKTDLVPAQLKTQIDDFNSWVYDSINNGVYKTGFAEKAEVYESEVNNVFEHLDKVEKILSDKYSKLKAKYGEEDRQKILGEFFTVGDQLTEADIRLYTTVIRFDPVYVQHFKCNFTSIRAGYPFIHLWVRNLYWNYDAFRYTTDFDHIKLHYTRSHTRINPLGITPLGPKPDIRPL"},{"created_at":"2011-05-27T02:54:50.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Glutathione S-transferase omega-like 3","uniprot_id":"Q04806","uniprot_name":"GTO3_YEAST","enzyme":true,"transporter":false,"gene_name":"GTO3","num_residues":366,"molecular_weight":"42402.60156","theoretical_pi":"7.63","general_function":"Posttranslational modification, protein turnover, chaperones","specific_function":"Active as '1-Cys' thiol transferase against beta- hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB)","reactions":[{"id":2699,"direction":"\u003e","locations":"Peroxisome;Cytoplasm;Endoplasmic reticulum membrane; Peripheral membrane protein","altext":"RX + glutathione = HX + R-S-glutathione.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692580","genbank_protein_id":"51012611","gene_card_id":"GTO3","chromosome_location":"chromosome 13","locus":"YMR251W","synonyms":[],"enzyme_classes":["2.5.1.18"],"go_classes":[],"pfams":[],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGTCTGAAAAATCAGCTAGCAATAACAAAGCTGAATTCAAAAGGCAGTCATCGCCATTCAGAGAAATCATCTCTGCGGATCACCCAATTTATAAACCTGCTAAGGGAAGGTACTGGCTGTATGTGGCGCTACCATGCCCATGGGCACAAAGAACCTTGATCACCAGGGCCCTGAAAGGGCTAGCGCCTATAATCGGGTGCAGTGTAGCGCATTGGCACCTGGATGACAAAGGCTGGCGATTCCTTGAAGAAGGAGATGGGAAAACCAATGAAAGGCACTGGTTTGACATTGCAGGCGGAATTAGCTCAGTAAATTTAAATACCAGTACTCCTGTGGCTAACATACCCAATAACGCGCATCGGTTGTTGGTCGACGGAACAGATGAACCGCATTACGGGTACAAGAGACTAAGCGACTTCTATTTCAAAACAAAGCCAGACTATAAGGGAAGATTCACCGTACCTGTTCTTTGGGACTTGGAAACATGCACTATAGTAAACAATGAAAGCAGTGATATCATCGGAATTATGAATTCCGCTGCGTTTGATGAGTTTGTCGGCGAAGAATACCGTCAAGTCCGTCTGGTACCTCGGTCTCTAGAGGCACAGATTACAGAGTTCAACTCTTGGGTGTACGATAAAATCAACAACGGTGTATACAAGGCCGGTTTTGCAGAATGTGCAGAGGTATACGAGAGGGAGGTAACAAGCCTTTTTCAATATCTTGACAAATTGGAAAATCTTCTGGACAAGAAGTACACAGATTTGGAGGCGGAGTATGGTAAGAACAACAAGGACAAGATACTAGATCGCTACTTTGCCATCGGAGACACTCTGACCGAGGCGGACGTGAGACTCTACCCAACGATAGTAAGGTTCGACGTGGTATACCATCAACACTTCAAATGCAATCTGGCCACCATCAGAGATGATTATTCCCGTATACACACGTGGCTCAAGAATATATACTGGCGCCACGAAGCCTTCCAGCGCACAACGGACTTTACCCACATAAAACTCGGATATACTCGCTCGCAGCCACGGGTCAACCCGATTGGGATCACCCCACTGGGGCCCAAGCCTGATATCCGACCTCCATGA","protein_sequence":"MSEKSASNNKAEFKRQSSPFREIISADHPIYKPAKGRYWLYVALPCPWAQRTLITRALKGLAPIIGCSVAHWHLDDKGWRFLEEGDGKTNERHWFDIAGGISSVNLNTSTPVANIPNNAHRLLVDGTDEPHYGYKRLSDFYFKTKPDYKGRFTVPVLWDLETCTIVNNESSDIIGIMNSAAFDEFVGEEYRQVRLVPRSLEAQITEFNSWVYDKINNGVYKAGFAECAEVYEREVTSLFQYLDKLENLLDKKYTDLEAEYGKNNKDKILDRYFAIGDTLTEADVRLYPTIVRFDVVYHQHFKCNLATIRDDYSRIHTWLKNIYWRHEAFQRTTDFTHIKLGYTRSQPRVNPIGITPLGPKPDIRPP"},{"created_at":"2011-05-27T02:55:20.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Oligopeptide transporter 1","uniprot_id":"P40897","uniprot_name":"OPT1_YEAST","enzyme":false,"transporter":true,"gene_name":"OPT1","num_residues":799,"molecular_weight":"91614.79688","theoretical_pi":"9.02","general_function":"Involved in transmembrane transport","specific_function":"High affinity transporter for glutathione. Also transports tetra- and pentapeptides like the opioids leucine enkephalin (Tyr-Gly-Gly-Phe-Leu) and methionine enkephalin (Tyr- Gly-Gly_Phe-Met) across the cell membrane","reactions":[],"signal_regions":"None","transmembrane_regions":"109-129;136-156;178-198;211-231;277-297;314-334;360-380;429-449;483-503;509-529;541-561;591-611;660-680;737-757","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein","genbank_gene_id":"Z34098","genbank_protein_id":"496950","gene_card_id":"OPT1","chromosome_location":"chromosome 10","locus":"YJL212C","synonyms":["High affinity glutathione transporter 1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"OPT","identifier":"PF03169"}],"pathways":[],"gene_sequence":"ATGAGTACCATTTATAGGGAGAGCGACTCGTTGGAGTCGGAGCCCTCGCCAACGCCAACAACCATTCCTATCCAGATCAATATGGAAGAGGAAAAGAAAGATGCTTTCGTTAAGAATATTGACGAGGACGTCAATAATCTCACTGCGACTACTGATGAGGAGGACCGCGATCCGGAAAGCCAAAAATTCGACAGGCATTCCATACAGGAGGAAGGTCTCGTTTGGAAGGGCGACCCTACATACTTGCCCAATTCTCCATATCCTGAAGTGAGATCGGCGGTGTCCATCGAGGATGACCCCACCATCCGCCTCAACCACTGGAGAACGTGGTTCTTGACCACGGTGTTTGTGGTAGTTTTCGCCGGTGTTAATCAATTTTTTTCCCTGAGATATCCATCGCTAGAGATCAACTTCCTTGTTGCACAAGTTGTTTGCTACCCAATTGGTAGGATACTGGCTCTCTTGCCCGACTGGAAGTGTTCTAAAGTGCCATTTTTCGATTTAAACCCGGGCCCATTTACCAAAAAGGAACACGCCGTGGTCACAATTGCCGTGGCGCTTACTTCCTCTACTGCATACGCTATGTACATTTTGAACGCCCAGGGAAGCTTTTACAACATGAAACTTAATGTCGGATATCAGTTCTTGTTGGTTTGGACATCTCAAATGATTGGTTATGGTGCTGCAGGTCTTACCAGAAGATGGGTCGTCAACCCTGCAAGCTCTATCTGGCCTCAGACTTTAATTTCAGTGTCCTTGTTTGATTCGTTGCACTCGAGAAAAGTTGAAAAGACAGTCGCAAATGGTTGGACGATGCCCCGTTACAGGTTCTTCTTAATCGTCCTTATCGGATCGTTCATCTGGTATTGGGTACCTGGATTCCTCTTTACCGGTCTGTCCTATTTCAACGTTATCCTATGGGGGTCGAAGACAAGACACAATTTCATCGCTAACACAATCTTTGGTACTCAAAGTGGTCTCGGTGCGTTGCCAATTACATTTGACTACACCCAGGTTTCCCAAGCCATGTCCGGCTCTGTTTTCGCCACACCATTCTACGTCTCCGCCAACACCTATGCATCAGTGTTGATATTCTTCGTCATAGTGCTGCCATGTCTTTATTTTACGAATACCTGGTATGCCAAATACATGCCCGTCATTTCAGGTTCTACTTATGACAACACTCAAAACAAATACAACGTAACAAAGATTCTTAACGAGGATTATTCCATTAATCTTGAGAAATATAAGGAATACTCACCGGTATTCGTTCCATTTTCCTATCTTTTGTCGTATGCTTTAAATTTTGCCGCTGTTATCGCCGTTTTTGTCCACTGCATCTTATACCACGGTAAAGATATTGTCGCCAAGTTTAAAGACCGTAAAAATGGTGGCACTGACATTCACATGAGAATCTACTCCAAGAACTATAAGGATTGTCCCGATTGGTGGTATTTACTTTTGCAGATTGTCATGATCGGTTTAGGATTTGTAGCAGTGTGCTGTTTCGATACTAAGTTCCCAGCTTGGGCATTTGTTATTGCAATATTAATTTCCCTTGTAAATTTCATCCCGCAAGGTATCTTGGAAGCAATGACTAACCAACACGTAGGTTTGAATATTATCACAGAATTGATCTGCGGTTATATGCTGCCTTTAAGACCAATGGCAAACTTATTATTCAAGCTATACGGATTTATTGTCATGAGACAAGGCTTGAATTTGAGTAGAGATTTGAAATTAGCCATGTACATGAAGGTTTCCCCTCGTTTGATCTTTGCCGTTCAAATCTATGCCACTATCATATCAGGCATGGTTAACGTTGGTGTCCAGGAATGGATGATGCATAATATCGATGGCTTATGTACCACCGATCAACCAAATGGCTTCACTTGTGCTAATGGTCGCACGGTTTTCAATGCTTCCATTATCTGGTCTTTGCCAAAGTATCTTTTCTCATCAGGGCGCATTTATAATCCGCTGATGTGGTTCTTCTTGATTGGTTTGCTATTCCCACTAGCCGTTTATGCTGTTCAATGGAAATTCCCTAAATTTAAATTTGCTAAGCACATTCATACTCCTGTATTTTTCACAGGCCCAGGTAATATTCCACCAAGCACACCTTATAACTACTCATTATTTTTTGCAATGTCATTCTGCCTAAACTTGATAAGAAAAAGATGGAGAGCTTGGTTCAATAAGTACAATTTCGTCATGGGGGCCGGTGTTGAAGCAGGTGTGGCAATCTCCGTCGTCATCATCTTCTTGTGTGTACAGTACCCAGGTGGTAAGCTCAGCTGGTGGGGAAACAACGTTTGGAAAAGAACGTATGATAATGATTATAAAAAATTTTATACCTTAAAGAAAGGTGAGACATTTGGTTATGATAAATGGTGGTAA","protein_sequence":"MSTIYRESDSLESEPSPTPTTIPIQINMEEEKKDAFVKNIDEDVNNLTATTDEEDRDPESQKFDRHSIQEEGLVWKGDPTYLPNSPYPEVRSAVSIEDDPTIRLNHWRTWFLTTVFVVVFAGVNQFFSLRYPSLEINFLVAQVVCYPIGRILALLPDWKCSKVPFFDLNPGPFTKKEHAVVTIAVALTSSTAYAMYILNAQGSFYNMKLNVGYQFLLVWTSQMIGYGAAGLTRRWVVNPASSIWPQTLISVSLFDSLHSRKVEKTVANGWTMPRYRFFLIVLIGSFIWYWVPGFLFTGLSYFNVILWGSKTRHNFIANTIFGTQSGLGALPITFDYTQVSQAMSGSVFATPFYVSANTYASVLIFFVIVLPCLYFTNTWYAKYMPVISGSTYDNTQNKYNVTKILNEDYSINLEKYKEYSPVFVPFSYLLSYALNFAAVIAVFVHCILYHGKDIVAKFKDRKNGGTDIHMRIYSKNYKDCPDWWYLLLQIVMIGLGFVAVCCFDTKFPAWAFVIAILISLVNFIPQGILEAMTNQHVGLNIITELICGYMLPLRPMANLLFKLYGFIVMRQGLNLSRDLKLAMYMKVSPRLIFAVQIYATIISGMVNVGVQEWMMHNIDGLCTTDQPNGFTCANGRTVFNASIIWSLPKYLFSSGRIYNPLMWFFLIGLLFPLAVYAVQWKFPKFKFAKHIHTPVFFTGPGNIPPSTPYNYSLFFAMSFCLNLIRKRWRAWFNKYNFVMGAGVEAGVAISVVIIFLCVQYPGGKLSWWGNNVWKRTYDNDYKKFYTLKKGETFGYDKWW"},{"created_at":"2011-05-27T02:56:01.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Glutathione S-transferase 2","uniprot_id":"Q12390","uniprot_name":"GST2_YEAST","enzyme":true,"transporter":false,"gene_name":"GTT2","num_residues":233,"molecular_weight":"26339.40039","theoretical_pi":"8.93","general_function":"Involved in protein binding","specific_function":"RX + glutathione = HX + R-S-glutathione","reactions":[{"id":2699,"direction":"\u003e","locations":"Peroxisome;Cytoplasm;Endoplasmic reticulum membrane; Peripheral membrane protein","altext":"RX + glutathione = HX + R-S-glutathione.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY557940","genbank_protein_id":"45269772","gene_card_id":"GTT2","chromosome_location":"chromosome 12","locus":"YLL060C","synonyms":["GST-II"],"enzyme_classes":["2.5.1.18"],"go_classes":[],"pfams":[{"name":"GST_C","identifier":"PF00043"},{"name":"GST_N","identifier":"PF02798"}],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGAATGGCAGAGGTTTCCTGATTTACAATGGAGGTGAAAAGATGAAACAAAAAATGATAATATATGACACACCCGCAGGGCCTTATCCGGCCCGAGTCCGCATTGCCTTGGCTGAGAAGAACATGCTATCAAGTGTGCAATTTGTGAGGATCAACCTCTGGAAGGGAGAGCACAAGAAGCCTGAATTTCTTGCCAAGAACTATTCAGGCACAGTGCCAGTGCTTGAACTTGATGACGGGACTTTAATCGCTGAATGCACAGCCATTACTGAATACATTGATGCACTTGATGGTACACCCACTCTTACCGGCAAAACACCGCTGGAAAAAGGCGTAATCCACATGATGAACAAACGCGCAGAGTTGGAACTGCTCGACCCTGTTAGTGTTTATTTTCACCATGCTACACCTGGATTGGGGCCTGAAGTCGAGCTTTACCAAAACAAAGAGTGGGGACTTCGCCAGCGCGACAAAGCCCTACATGGAATGCATTATTTTGATACCGTTCTCAGAGAACGCCCATATGTTGCTGGTGATTCATTCTCAATGGCTGACATCACAGTAATAGCTGGTCTAATATTTGCTGCAATTGTAAAACTACAAGTGCCGGAAGAGTGCGAGGCGCTTCGAGCTTGGTATAAGAGAATGCAACAGCGCCCCAGCGTGAAGAAACTGCTAGAAATCCGTTCAAAATCCTCGTAA","protein_sequence":"MNGRGFLIYNGGEKMKQKMIIYDTPAGPYPARVRIALAEKNMLSSVQFVRINLWKGEHKKPEFLAKNYSGTVPVLELDDGTLIAECTAITEYIDALDGTPTLTGKTPLEKGVIHMMNKRAELELLDPVSVYFHHATPGLGPEVELYQNKEWGLRQRDKALHGMHYFDTVLRERPYVAGDSFSMADITVIAGLIFAAIVKLQVPEECEALRAWYKRMQQRPSVKKLLEIRSKSS"},{"created_at":"2011-05-27T02:56:34.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Hydroxyacylglutathione hydrolase, cytoplasmic isozyme","uniprot_id":"Q05584","uniprot_name":"GLO2_YEAST","enzyme":true,"transporter":false,"gene_name":"GLO2","num_residues":274,"molecular_weight":"31326.30078","theoretical_pi":"6.11","general_function":"Involved in hydrolase activity","specific_function":"Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid","reactions":[{"id":1644,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2700,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate.","export":false,"pw_reaction_id":null,"source":null},{"id":14118,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006549","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U51030","genbank_protein_id":"1230643","gene_card_id":"GLO2","chromosome_location":"chromosome 4","locus":"YDR272W","synonyms":["Glyoxalase II","Glx II"],"enzyme_classes":["3.1.2.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Lactamase_B","identifier":"PF00753"}],"pathways":[{"name":"Pyruvate metabolism","kegg_map_id":"00620"}],"gene_sequence":"ATGCAGGTTAAATCGATTAAAATGAGATGGGAGTCTGGTGGTGTTAATTACTGCTATCTATTGTCCGACAGTAAAAATAAAAAATCGTGGCTAATCGATCCAGCAGAGCCTCCTGAGGTTCTGCCAGAGTTGACTGAGGATGAGAAAATAAGTGTTGAAGCAATTGTTAATACACATCACCATTATGACCATGCAGATGGTAACGCTGATATCTTGAAGTATTTAAAAGAGAAAAATCCAACTTCAAAAGTTGAGGTTATAGGAGGGTCAAAGGACTGCCCAAAGGTTACGATAATTCCGGAGAATTTGAAAAAGTTACACCTAGGTGACTTAGAGATTACTTGTATTAGGACGCCCTGCCATACCAGAGACTCTATCTGTTATTATGTGAAAGATCCAACAACAGATGAGCGCTGCATTTTTACTGGCGATACACTATTTACCGCTGGTTGCGGTAGGTTTTTTGAGGGTACAGGCGAAGAAATGGATATAGCTCTGAACAATTCTATCTTAGAAACTGTGGGCAGGCAGAACTGGAGTAAAACGAGGGTTTATCCAGGACACGAATACACAAGTGATAATGTAAAGTTTGTTCGTAAGATTTACCCGCAAGTTGGTGAAAATAAAGCATTGGATGAGTTAGAACAATTCTGCTCCAAGCATGAAGTCACAGCAGGGCGGTTCACTTTGAAAGATGAGGTAGAATTTAATCCATTCATGAGATTAGAAGATCCAAAGGTCCAAAAAGCTGCCGGAGATACGAATAATTCATGGGACAGAGCTCAAATTATGGATAAATTGAGAGCTATGAAAAACCGTATGTAG","protein_sequence":"MQVKSIKMRWESGGVNYCYLLSDSKNKKSWLIDPAEPPEVLPELTEDEKISVEAIVNTHHHYDHADGNADILKYLKEKNPTSKVEVIGGSKDCPKVTIIPENLKKLHLGDLEITCIRTPCHTRDSICYYVKDPTTDERCIFTGDTLFTAGCGRFFEGTGEEMDIALNNSILETVGRQNWSKTRVYPGHEYTSDNVKFVRKIYPQVGENKALDELEQFCSKHEVTAGRFTLKDEVEFNPFMRLEDPKVQKAAGDTNNSWDRAQIMDKLRAMKNRM"},{"created_at":"2011-05-27T02:57:54.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Glutathione S-transferase omega-like 1","uniprot_id":"P48239","uniprot_name":"GTO1_YEAST","enzyme":true,"transporter":false,"gene_name":"GTO1","num_residues":356,"molecular_weight":"41300.19922","theoretical_pi":"9.19","general_function":"Posttranslational modification, protein turnover, chaperones","specific_function":"Active as '1-Cys' thiol transferase against beta- hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB)","reactions":[{"id":2699,"direction":"\u003e","locations":"Peroxisome;Cytoplasm;Endoplasmic reticulum membrane; Peripheral membrane protein","altext":"RX + glutathione = HX + R-S-glutathione.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Peroxisome","genbank_gene_id":"X85807","genbank_protein_id":"1045259","gene_card_id":"GTO1","chromosome_location":"chromosome 7","locus":"YGR154C","synonyms":[],"enzyme_classes":["2.5.1.18"],"go_classes":[],"pfams":[],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGTCAGTATCTTACAAGGGAACAATTTCTAAGACACATTCTGTTTTTAAACCAGAAAAAGGAAGGTATTATATTTACGGGGCCCTTGGGTGTCCATTCACTCATAGAGCCATTCTTGCCAGGTCTTTGAAGAAATTAGAACCTGTTCTAGGGCTTGTGTTATCTCACTGGCAATTAGACTCCAAGGGTGCCCGTTTCTTACCTGCTCCACACCGGCCGGAAAAATATAAAGAGAGATTCTTTACTGCCACTGGTGGCATTGCTTCAGCTAAATTAGACGAATCTGAGGAGTTAGGTGATGTGAACAATGACTCTGCAAGGTTGTTCGTGGATGGCGCTTTCGACCCGGTGGAAAATATATCAAGGTTAAGCGAGTTGTACTACTTAAATGATCCTAAGTACCCCGGTACAAAGTTCACTGTGCCTGTTCTGTGGGATTCTAAAACAAGGAAAATTGTTAACAATGAGAGTGGCGATATCATAAGAATTTTGAACAGTGGCGTGTTTGATGAATTTATCCAAAGCGAAGAAACGAACGTGATTGATCTAGTTCCGCATGATTTAATAGACGAGATTGATAAGAACATCAAATGGGTTCATCCGAAGATTAATCTTGGTGTCTATAAAGTCGGATTAGCAGAAAACGGAAAGATTTACGAAACTGAAGTAAAAACACTGTTTGAAAACTTGCAGAAGATGGAATGTGTACTAAAAGAAAATTATAAGCGCTTAGAGGAGCAATTCAGTGGTAACAAACAGAAAATCTTGGCTAAATATTTTGTTTTAGGACAGAGGTTAACTGAAGCGGATATCAGATTGTATCCATCAATAATTAGATTTGACGTCGTGTACGTGCAGCACTTCAAATGCAATTTGAAAACTATAAGGGATGGTTTCCCGTACCTTCATTTGTGGTTGATTAATCTATACTGGAATTACGCAGAGTTTAGATTTACTACAGATTTTAATCATATTAAGCTCTTTTACATCAGGATGGAAGTAAGTAGGAACAAGATCAATCAGTTTGGTATAGTGCCATTAGGCCCAAAGCCTGACATTTCTAGATTATGA","protein_sequence":"MSVSYKGTISKTHSVFKPEKGRYYIYGALGCPFTHRAILARSLKKLEPVLGLVLSHWQLDSKGARFLPAPHRPEKYKERFFTATGGIASAKLDESEELGDVNNDSARLFVDGAFDPVENISRLSELYYLNDPKYPGTKFTVPVLWDSKTRKIVNNESGDIIRILNSGVFDEFIQSEETNVIDLVPHDLIDEIDKNIKWVHPKINLGVYKVGLAENGKIYETEVKTLFENLQKMECVLKENYKRLEEQFSGNKQKILAKYFVLGQRLTEADIRLYPSIIRFDVVYVQHFKCNLKTIRDGFPYLHLWLINLYWNYAEFRFTTDFNHIKLFYIRMEVSRNKINQFGIVPLGPKPDISRL"},{"created_at":"2011-05-27T02:58:20.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Monothiol glutaredoxin-5, mitochondrial","uniprot_id":"Q02784","uniprot_name":"GLRX5_YEAST","enzyme":true,"transporter":false,"gene_name":"GRX5","num_residues":150,"molecular_weight":"16931.30078","theoretical_pi":"4.54","general_function":"Involved in electron carrier activity","specific_function":"Monothiol glutaredoxin involved in iron-sulfur biogenesis. Required for normal iron homeostasis. Protects cells against oxidative damage due to reactive oxygen species","reactions":[{"id":1584,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"U39205","genbank_protein_id":"1079683","gene_card_id":"GRX5","chromosome_location":"chromosome 16","locus":"YPL059W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" disulfide oxidoreductase activity"},{"category":"Function","description":" protein disulfide oxidoreductase activity"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" cell redox homeostasis"}],"pfams":[{"name":"Glutaredoxin","identifier":"PF00462"}],"pathways":[],"gene_sequence":"ATGTTTCTCCCAAAATTCAATCCCATAAGGTCATTTTCCCCCATCCTCCGGGCTAAGACTCTTCTTCGTTACCAAAATCGGATGTATTTGAGCACAGAGATAAGAAAAGCTATTGAAGATGCCATCGAATCGGCTCCAGTGGTTCTTTTCATGAAAGGTACTCCTGAATTTCCCAAGTGTGGATTTTCAAGAGCAACCATTGGATTATTAGGAAATCAAGGCGTTGACCCGGCCAAATTTGCGGCTTATAATGTTTTAGAAGACCCAGAGCTACGTGAAGGTATCAAAGAGTTTTCAGAATGGCCAACTATTCCACAGTTATATGTAAACAAAGAATTCATTGGTGGATGTGATGTTATTACAAGTATGGCACGCTCTGGTGAATTGGCCGATTTGCTAGAAGAGGCACAGGCATTGGTACCTGAAGAAGAAGAAGAAACCAAAGATCGTTGA","protein_sequence":"MFLPKFNPIRSFSPILRAKTLLRYQNRMYLSTEIRKAIEDAIESAPVVLFMKGTPEFPKCGFSRATIGLLGNQGVDPAKFAAYNVLEDPELREGIKEFSEWPTIPQLYVNKEFIGGCDVITSMARSGELADLLEEAQALVPEEEEETKDR"},{"created_at":"2011-05-27T02:58:52.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Peroxiredoxin HYR1","uniprot_id":"P40581","uniprot_name":"GPX3_YEAST","enzyme":true,"transporter":false,"gene_name":"HYR1","num_residues":163,"molecular_weight":"18641.40039","theoretical_pi":"8.42","general_function":"Involved in glutathione peroxidase activity","specific_function":"Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator YAP1, which is involved in transcription activation of genes of the oxidative stress response pathway. May also play a direct role in hydroperoxide scavenging, being the most active of three closely related S.cerevisiae peroxiredoxins (GPX1, GPX2, and HYP1/GPX3) with respect to peroxide and lipid hydroperoxide reduction. The three enzymes are not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, HYP1 is directly oxidized at Cys-36 to form a cysteine sulfenic acid (-SOH). Cys-36-SOH then forms either an intramolecular disulfide bond (Cys-36 with Cys-82) or a transient, intermolecular disulfide bond with 'Cys-598' of YAP1, which is further resolved into a YAP1 intramolecular disulfide bond ('Cys-303' with 'Cys-598') and a reduced Cys-36 in HYP1/GPX3","reactions":[{"id":1584,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2701,"direction":"\u003e","locations":"Nucleus. Chromosome, telomere (Potential);Cytoplasm;Mitochondrion","altext":"2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.","export":false,"pw_reaction_id":null,"source":null},{"id":2241,"direction":"\u003e","locations":"Cytoplasm","altext":"2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + H2O","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U22446","genbank_protein_id":"727367","gene_card_id":"HYR1","chromosome_location":"chromosome 9","locus":"YIR037W","synonyms":["Glutathione peroxidase 3","Hydrogen peroxide resistance protein 1","Oxidant receptor peroxidase 1","Phospholipid hydroperoxide glutathione peroxidase 3","PHGPx3"],"enzyme_classes":["1.11.1.15","1.11.1.12"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" antioxidant activity"},{"category":"Function","description":" peroxidase activity"},{"category":"Function","description":" glutathione peroxidase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" response to stimulus"},{"category":"Process","description":" response to stress"},{"category":"Process","description":" response to oxidative stress"}],"pfams":[{"name":"GSHPx","identifier":"PF00255"}],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGTCAGAATTCTATAAGCTAGCACCTGTTGACAAGAAAGGCCAACCATTCCCCTTCGACCAATTAAAGGGAAAAGTGGTGCTTATCGTTAATGTTGCCTCCAAATGTGGATTCACTCCTCAATACAAAGAACTAGAGGCCTTGTACAAACGTTATAAGGACGAAGGATTTACCATCATCGGGTTCCCATGCAACCAGTTTGGCCACCAAGAACCTGGCTCTGATGAAGAAATTGCCCAGTTCTGCCAACTGAACTATGGCGTGACTTTCCCCATTATGAAAAAAATTGACGTTAATGGTGGCAATGAGGACCCTGTTTACAAGTTTTTGAAGAGCCAAAAATCCGGTATGTTGGGCTTGAGAGGTATCAAATGGAATTTTGAAAAATTCTTAGTCGATAAAAAGGGTAAAGTGTACGAAAGATACTCTTCACTAACCAAACCTTCTTCGTTGTCCGAAACCATCGAAGAACTTTTGAAAGAGGTGGAATAG","protein_sequence":"MSEFYKLAPVDKKGQPFPFDQLKGKVVLIVNVASKCGFTPQYKELEALYKRYKDEGFTIIGFPCNQFGHQEPGSDEEIAQFCQLNYGVTFPIMKKIDVNGGNEDPVYKFLKSQKSGMLGLRGIKWNFEKFLVDKKGKVYERYSSLTKPSSLSETIEELLKEVE"},{"created_at":"2011-05-27T02:59:37.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Glutathione S-transferase 1","uniprot_id":"P40582","uniprot_name":"GST1_YEAST","enzyme":true,"transporter":false,"gene_name":"GTT1","num_residues":234,"molecular_weight":"26794.5","theoretical_pi":"6.64","general_function":"Involved in protein binding","specific_function":"RX + glutathione = HX + R-S-glutathione","reactions":[{"id":2699,"direction":"\u003e","locations":"Peroxisome;Cytoplasm;Endoplasmic reticulum membrane; Peripheral membrane protein","altext":"RX + glutathione = HX + R-S-glutathione.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Peripheral membrane protein","genbank_gene_id":"Z38061","genbank_protein_id":"557844","gene_card_id":"GTT1","chromosome_location":"chromosome 9","locus":"YIR038C","synonyms":["GST-I"],"enzyme_classes":["2.5.1.18"],"go_classes":[],"pfams":[{"name":"GST_C","identifier":"PF00043"},{"name":"GST_N","identifier":"PF02798"}],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGTCGTTGCCAATTATCAAAGTCCATTGGTTGGACCATTCCAGAGCGTTCAGACTTTTGTGGTTATTAGACCATTTGAACCTTGAATATGAAATTGTCCCTTATAAAAGAGATGCTAACTTCCGTGCTCCACCAGAATTAAAGAAAATTCACCCATTAGGAAGATCTCCATTGTTAGAAGTTCAAGACAGAGAAACTGGTAAGAAGAAGATACTTGCCGAGTCCGGTTTCATCTTCCAATATGTCTTGCAGCATTTTGATCATTCACACGTTTTAATGAGCGAAGATGCTGATATTGCAGACCAGATTAACTATTATCTGTTTTATGTAGAAGGTTCCTTGCAACCACCTTTAATGATTGAGTTCATTCTTTCAAAGGTGAAGGATTCTGGTATGCCCTTCCCTATTTCGTACTTGGCAAGAAAAGTGGCAGACAAGATCAGTCAGGCATACTCTAGTGGTGAAGTTAAGAACCAGTTCGACTTTGTGGAGGGTGAAATTTCCAAAAATAACGGCTACCTGGTTGATGGGAAGTTGAGCGGTGCCGATATCTTGATGTCTTTCCCTTTGCAGATGGCGTTTGAAAGAAAGTTTGCCGCACCAGAGGATTATCCTGCCATTTCCAAATGGTTAAAGACCATAACCTCAGAGGAGTCGTATGCTGCTTCTAAGGAAAAGGCGCGTGCTTTAGGTAGCAATTTCTAA","protein_sequence":"MSLPIIKVHWLDHSRAFRLLWLLDHLNLEYEIVPYKRDANFRAPPELKKIHPLGRSPLLEVQDRETGKKKILAESGFIFQYVLQHFDHSHVLMSEDADIADQINYYLFYVEGSLQPPLMIEFILSKVKDSGMPFPISYLARKVADKISQAYSSGEVKNQFDFVEGEISKNNGYLVDGKLSGADILMSFPLQMAFERKFAAPEDYPAISKWLKTITSEESYAASKEKARALGSNF"},{"created_at":"2011-05-27T03:00:10.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Glutaredoxin-2, mitochondrial","uniprot_id":"P17695","uniprot_name":"GLRX2_YEAST","enzyme":true,"transporter":false,"gene_name":"GRX2","num_residues":143,"molecular_weight":"15861.2998","theoretical_pi":"7.41","general_function":"Involved in electron carrier activity","specific_function":"Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage","reactions":[{"id":1584,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Mitochondrion.","genbank_gene_id":"AY692896","genbank_protein_id":"51013243","gene_card_id":"GRX2","chromosome_location":"chromosome 4","locus":"YDR513W","synonyms":["Glutathione-dependent oxidoreductase 2","Thioltransferase"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" disulfide oxidoreductase activity"},{"category":"Function","description":" protein disulfide oxidoreductase activity"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" cell redox homeostasis"}],"pfams":[{"name":"Glutaredoxin","identifier":"PF00462"}],"pathways":[],"gene_sequence":"ATGGAGACCAATTTTTCCTTCGACTCGAATTTAATTGTTATTATCATTATCACGTTGTTTGCCACAAGAATTATTGCTAAAAGATTTTTATCTACTCCAAAAATGGTATCCCAGGAAACAGTTGCTCACGTAAAGGATCTGATTGGCCAAAAGGAAGTGTTTGTTGCAGCAAAGACATACTGCCCTTACTGTAAAGCTACTTTGTCTACCCTCTTCCAAGAATTGAACGTTCCCAAATCCAAGGCCCTTGTGTTGGAATTAGATGAAATGAGCAATGGCTCAGAGATTCAAGACGCTTTAGAAGAAATCTCGGGCCAAAAAACTGTACCTAACGTATACATCAATGGCAAGCACATTGGTGGTAACAGCGATTTGGAAACTTTGAAGAAAAATGGCAAGTTAGCTGAAATATTGAAGCCGGTATTTCAATAG","protein_sequence":"METNFSFDSNLIVIIIITLFATRIIAKRFLSTPKMVSQETVAHVKDLIGQKEVFVAAKTYCPYCKATLSTLFQELNVPKSKALVLELDEMSNGSEIQDALEEISGQKTVPNVYINGKHIGGNSDLETLKKNGKLAEILKPVFQ"},{"created_at":"2011-05-27T03:00:57.000Z","updated_at":"2011-05-29T14:01:22.000Z","name":"S-formylglutathione hydrolase","uniprot_id":"P40363","uniprot_name":"SFGH_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":299,"molecular_weight":"33934.0","theoretical_pi":"6.7","general_function":"Involved in carboxylesterase activity","specific_function":"Serine hydrolase involved in the detoxification of formaldehyde","reactions":[{"id":1958,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2702,"direction":"\u003e","locations":"Cytoplasm","altext":"S-formylglutathione + H(2)O = glutathione + formate.","export":false,"pw_reaction_id":null,"source":null},{"id":2703,"direction":"\u003e","locations":"Cytoplasm","altext":"4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1PV1","cellular_location":"Cytoplasm","genbank_gene_id":"X88851","genbank_protein_id":"895893","gene_card_id":null,"chromosome_location":null,"locus":"YJL068C","synonyms":["FGH"],"enzyme_classes":["3.1.2.12","3.1.1.56"],"go_classes":[{"category":"Component","description":" organelle"},{"category":"Component","description":" vesicle"},{"category":"Component","description":" cytoplasmic vesicle"},{"category":"Component","description":" cytoplasmic membrane-bounded vesicle"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" carboxylesterase activity"},{"category":"Function","description":" thiolester hydrolase activity"},{"category":"Function","description":" S-formylglutathione hydrolase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Esterase","identifier":"PF00756"}],"pathways":[{"name":"Methane metabolism","kegg_map_id":"00680"}],"gene_sequence":"GATCAAGTTGTCACATAACTCGAACTCTACCAAGACCAGCATGAACGTCAATATCTATTTGCCTAAGCACTATTACGCCCAAGATTTTCCAAGAAATAAGCGTATCCCAACTGTGTTTTACCTTTCTGGCTTGACGTGCACGCCAGACAACGCCTCTGAGAAGGCTTTTTGGCAGTTTCAAGCTGACAAGTACGGATTTGCAATAGTCTTTCCGGATACGTCCCCACGTGGTGACGAAGTAGCCAATGATCCTGAGGGCTCCTGGGATTTTGGACAGGGCGCCGGATTCTATCTAAATGCCACCCAAGAACCATACGCCCAACATTACCAGATGTACGACTACATTCACAAAGAACTCCCACAAACATTAGATTCTCATTTTAACAAGAACGGTGACGTAAAGCTGGACTTCTTGGACAATGTTGCCATCACAGGCCATTCGATGGGGGGATATGGTGCAATTTGTGGGTATTTGAAGGGCTATTCCGGAAAGAGATACAAATCTTGTTCTGCCTTCGCCCCTATCGTGAACCCTTCCAACGTTCCCTGGGGTCAAAAAGCGTTTAAAGGTTATCTGGGCGAAGAAAAAGCCCAGTGGGAAGCGTACGACCCATGTTTATTAATCAAGAATATTAGACATGTGGGCGACGACAGAATTTTGATCCATGTAGGAGACTCCGATCCCTTTTTGGAAGAACACTTGAAACCGGAATTACTACTTGAGGCGGTGAAAGCCACTTCATGGCAGGACTACGTGGAAATAAAAAAAGTTCACGGCTTTGATCACTCCTATTACTTTGTCAGCACTTTCGTTCCAGAACATGCTGAATTTCATGCGCGAAACTTGGGTTTGATTTGA","protein_sequence":"MKVVKEFSVCGGRLIKLSHNSNSTKTSMNVNIYLPKHYYAQDFPRNKRIPTVFYLSGLTCTPDNASEKAFWQFQADKYGFAIVFPDTSPRGDEVANDPEGSWDFGQGAGFYLNATQEPYAQHYQMYDYIHKELPQTLDSHFNKNGDVKLDFLDNVAITGHSMGGYGAICGYLKGYSGKRYKSCSAFAPIVNPSNVPWGQKAFKGYLGEEKAQWEAYDPCLLIKNIRHVGDDRILIHVGDSDPFLEEHLKPELLLEAVKATSWQDYVEIKKVHGFDHSYYFVSTFVPEHAEFHARNLGLI"},{"created_at":"2011-05-27T03:01:53.000Z","updated_at":"2011-05-29T05:06:37.000Z","name":"Lactoylglutathione lyase","uniprot_id":"P50107","uniprot_name":"LGUL_YEAST","enzyme":true,"transporter":false,"gene_name":"GLO1","num_residues":326,"molecular_weight":"37208.69922","theoretical_pi":"6.84","general_function":"Involved in lactoylglutathione lyase activity","specific_function":"Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione","reactions":[{"id":1710,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2704,"direction":"\u003e","locations":null,"altext":"(R)-S-lactoylglutathione = glutathione + methylglyoxal.","export":false,"pw_reaction_id":null,"source":null},{"id":14117,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006548","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AJ297938","genbank_protein_id":"11182130","gene_card_id":"GLO1","chromosome_location":"chromosome 13","locus":"YML004C","synonyms":["Aldoketomutase","Glyoxalase I","Glx I","Ketone-aldehyde mutase","Methylglyoxalase","S-D-lactoylglutathione methylglyoxal lyase"],"enzyme_classes":["4.4.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" carbon-sulfur lyase activity"},{"category":"Function","description":" lactoylglutathione lyase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Glyoxalase","identifier":"PF00903"}],"pathways":[{"name":"Pyruvate metabolism","kegg_map_id":"00620"}],"gene_sequence":"ATGTCCACTGATAGTACACGCTATCCAATTCAGATTGAGAAAGCCTCGAATGATCCAACCCTTCTGCTTAATCACACATGTTTAAGAGTCAAGGATCCAGCAAGGGCTGTTAAGTTCTACACCGAACACTTCGGTATGAAGCTATTAAGCAGAAAGGATTTTGAAGAAGCAAAATTTAGCTTGTACTTTTTAAGCTTTCCAAAAGACGACATACCCAAAAATAAGAATGGAGAGCCTGATGTTTTTAGCGCACACGGTGTCTTAGAACTAACTCACAATTGGGGTACTGAAAAAAACCCAGACTACAAGATCAACAACGGGAATGAGGAACCTCATCGTGGATTTGGGCACATCTGTTTTTCTGTATCCGATATCAATAAAACCTGCGAAGAGCTAGAATCTCAGGGTGTCAAATTCAAGAAGAGACTCTCTGAAGGAAGACAGAAGGACATTGCGTTTGCTTTAGACCCTGATGGATACTGGATTGAGTTGATCACATATTCTAGAGAGGGTCAGGAATACCCAAAGGGCTCAGTAGGTAACAAGTTCAATCATACCATGATTCGTATTAAAAACCCAACCCGGTCTTTAGAATTCTACCAGAATGTGTTGGGCATGAAATTATTAAGAACTAGTGAGCACGAAAGTGCAAAATTTACGTTATACTTTCTTGGTTATGGCGTTCCAAAGACCGACAGCGTTTTTTCATGTGAAAGTGTGTTGGAGTTAACTCATAATTGGGGAACTGAGAATGATCCAAACTTCCACTATCATAACGGTAACTCAGAGCCCCAGGGTTATGGTCACATCTGCATAAGTTGCGATGACGCTGGCGCCCTTTGTAAAGAAATTGAAGTGAAATACGGCGATAAGATCCAATGGTCTCCTAAATTTAACCAAGGCAGAATGAAGAATATTGCCTTTTTGAAGGATCCTGATGGTTATTCCATTGAAGTCGTTCCTTATGGTTTGATTGCCTAA","protein_sequence":"MSTDSTRYPIQIEKASNDPTLLLNHTCLRVKDPARTVKFYTEHFGMKLLSRKDFEEAKFSLYFLSFPKDDIPKNKNGEPDVFSAHGVLELTHNWGTEKNPDYKINNGNEEPHRGFGHICFSVSDINKTCEELESQGVKFKKRLSEGRQKDIAFALGPDGYWIELITYSREGQEYPKGSVGNKFNHTMIRIKNPTRSLEFYQNVLGMKLLRTSEHESAKFTLYFLGYGVPKTDSVFSCESVLELTHNWGTENDPNFHYHNGNSEPQGYGHICISCDDAGALCKEIEVKYGDKIQWSPKFNQGRMKNIAFLKDPDGYSIEVVPHGLIA"},{"created_at":"2011-05-27T03:02:29.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Monothiol glutaredoxin-4","uniprot_id":"P32642","uniprot_name":"GLRX4_YEAST","enzyme":true,"transporter":false,"gene_name":"GRX4","num_residues":244,"molecular_weight":"27492.59961","theoretical_pi":"4.29","general_function":"Involved in electron carrier activity","specific_function":"Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (Probable)","reactions":[],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U18922","genbank_protein_id":"603415","gene_card_id":"GRX4","chromosome_location":"chromosome 5","locus":"YER174C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" disulfide oxidoreductase activity"},{"category":"Function","description":" protein disulfide oxidoreductase activity"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" cell redox homeostasis"}],"pfams":[{"name":"Glutaredoxin","identifier":"PF00462"},{"name":"Thioredoxin","identifier":"PF00085"}],"pathways":[],"gene_sequence":"ATGACTGTGGTTGAAATAAAAAGCCAGGACCAATTTACGCAACTAACCACTACAAACGCTGCTAATAAACTCATTGTCTTATATTTTAAAGCTCAATGGGCTGATCCTTGCAAAACTATGAGCCAGGTGCTAGAAGCTGTTAGTGAAAAAGTTAGGCAAGAGGATGTCCGGTTTTTATCAATAGATGCAGACGAACATCCAGAAATATCAGACCTTTTTGAGATTGCAGCCGTACCATACTTCGTCTTCATTCAAAATGGTACTATTGTAAAAGAAATATCAGCCGCAGATCCTAAGGAGTTTGTGAAAAGCTTAGAAATTCTTTCGAATGCTTCTGCCTCACTAGCGAACAATGCCAAGGGTCCTAAATCTACGTCTGATGAGGAAAGCAGCGGGTCTTCCGATGATGAAGAGGACGAAACTGAAGAAGAAATAAATGCTAGGCTGGTGAAGCTAGTACAAGCTGCACCTGTGATGCTATTCATGAAAGGAAGCCCATCAGAACCTAAATGCGGATTTTCTAGACAGTTAGTTGGTATCCTCAGAGAACACCAAATAAGGTTCGGATTTTTTGATATATTAAGAGACGAAAACGTTAGACAAAGCTTGAAGAAGTTTTCTGATTGGCCTACTTTTCCTCAGTTATATATCAATGGGGAGTTCCAGGGAGGTTTGGATATTATCAAGGAATCTATAGAAGAAGATCCTGAATATTTCCAACATGCTCTACAGTAA","protein_sequence":"MTVVEIKSQDQFTQLTTTNAANKLIVLYFKAQWADPCKTMSQVLEAVSEKVRQEDVRFLSIDADEHPEISDLFEIAAVPYFVFIQNGTIVKEISAADPKEFVKSLEILSNASASLANNAKGPKSTSDEESSGSSDDEEDETEEEINARLVKLVQAAPVMLFMKGSPSEPKCGFSRQLVGILREHQIRFGFFDILRDENVRQSLKKFSDWPTFPQLYINGEFQGGLDIIKESIEEDPEYFQHALQ"},{"created_at":"2011-05-27T03:03:46.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Bile pigment transporter 1","uniprot_id":"P14772","uniprot_name":"BPT1_YEAST","enzyme":false,"transporter":true,"gene_name":"BPT1","num_residues":1559,"molecular_weight":"176872.0","theoretical_pi":"7.73","general_function":"Involved in ATP binding","specific_function":"Cooperates for the ATP-dependent vacuolar transport of bilirubin and glutathione conjugates","reactions":[],"signal_regions":"None","transmembrane_regions":"30-50;85-105;111-127;140-160;179-199;284-304;334-354;411-431;435-455;519-539;561-581;973-993;1031-1052;1096-1116;1118-1138;1210-1230;1236-1256","pdb_id":null,"cellular_location":"Vacuole membrane; Multi-pass membrane protein","genbank_gene_id":"X91488","genbank_protein_id":"1495208","gene_card_id":"BPT1","chromosome_location":"chromosome 12","locus":"YLL015W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides"},{"category":"Function","description":" hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"},{"category":"Function","description":" binding"},{"category":"Function","description":" primary active transmembrane transporter activity"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" P-P-bond-hydrolysis-driven transmembrane transporter activity"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" ATPase activity, coupled to transmembrane movement of substances"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" pyrophosphatase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" nucleoside-triphosphatase activity"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" ATPase activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"},{"category":"Process","description":" transmembrane transport"}],"pfams":[{"name":"ABC_membrane","identifier":"PF00664"},{"name":"ABC_tran","identifier":"PF00005"}],"pathways":[],"gene_sequence":"ATGTCTTCACTAGAAGTGGTAGATGGGTGCCCCTATGGATACCGACCATATCCAGATAGTGGCACAAATGCATTAAATCCATGTTTTATATCAGTAATATCCGCCTGGCAAGCCGTCTTTTTCCTATTGATTGGTAGCTATCAATTGTGGAAACTTTATAAGAACAATAAAGTACCACCCAGATTTAAGAACTTTCCTACATTACCAAGTAAAATCAACAGTCGACATCTAACGCATTTGACCAATGTTTGCTTTCAGTCCACGCTTATAATTTGTGAACTGGCCTTGGTATCCCAATCTAGCGATAGGGTTTATCCATTTATACTAAAGAAGGCTCTGTACTTGAATCTCCTTTTCAATTTGGGTATTTCTCTCCCTACTCAATACTTAGCTTATTTTAAAAGTACATTTTCAATGGGCAACCAGCTTTTCTATTACATGTTTCAAATTCTTCTACAGCTCTTCTTGATATTGCAGAGGTACTATCATGGTTCTAGTAACGAAAGGCTTACTGTTATTAGCGGACAAACTGCTATGATTTTAGAAGTGCTCCTTCTTTTCAATTCTGTGGCAATTTTTATTTATGATCTATGCATTTTTGAGCCAATTAACGAATTATCTGAATACTACAAGAAAAATGGGTGGTATCCCCCCGTTCATGTACTATCCTATATTACATTTATCTGGATGAACAAACTGATTGTGGAAACTTACCGTAACAAGAAAATCAAAGATCCTAACCAGTTACCATTGCCGCCAGTAGATCTGAATATTAAGTCGATAAGTAAGGAATTTAAGGCTAACTGGGAATTGGAAAAATGGTTGAATAGAAATTCTCTTTGGAGGGCCATTTGGAAGTCATTTGGTAGGACTATTTCTGTGGCTATGCTGTATGAAACGACATCTGATTTACTTTCTGTAGTACAGCCCCAGTTTCTACGGATATTCATAGATGGTTTGAACCCGGAAACATCTTCTAAATATCCTCCTTTAAATGGTGTATTTATTGCTCTAACCCTTTTCGTAATCAGCGTGGTTTCTGTGTTCCTCACCAATCAATTTTATATTGGAATTTTTGAGGCTGGTTTGGGGATAAGAGGCTCTTTAGCTTCTTTAGTGTATCAGAAGTCCTTAAGATTGACGCTAGCAGAGCGTAACGAAAAATCTACTGGTGACATCTTAAATTTGATGTCTGTGGATGTGTTAAGGATCCAGCGGTTTTTCGAAAATGCCCAAACCATTATTGGCGCTCCTATTCAGATTATTGTTGTATTAACTTCCCTGTACTGGTTGCTAGGAAAGGCTGTTATTGGAGGGTTGGTTACTATGGCTATTATGATGCCTATCAATGCCTTCTTATCTAGAAAGGTAAAAAAGCTATCAAAAACTCAAATGAAGTATAAGGACATGAGAATCAAGACTATTACAGAGCTTTTGAATGCTATAAAATCTATTAAATTATACGCCTGGGAGGAACCTATGATGGCAAGATTGAATCATGTTCGTAATGATATGGAGTTGAAAAATTTTCGGAAAATTGGTATAGTGAGCAATCTGATATATTTTGCGTGGAATTGTGTACCTTTAATGGTGACATGTTCCACATTTGGCTTATTTTCTTTATTTAGTGATTCTCCGTTATCTCCTGCCATTGTCTTCCCTTCATTATCTTTATTTAATATTTTGAACAGTGCCATCTATTCCGTTCCATCCATGATAAATACCATTATAGAGACAAGCGTTTCTATGGAAAGATTAAAGTCATTCCTACTTAGTGACGAAATTGATGATTCGTTCATCGAACGTATTGATCCTTCAGCGGATGAAAGAGCGTTACCTGCTATAGAGATGAATAATATTACATTTTTATGGAAATCAAAAGAAGTATTAACATCTAGCCAATCTGGAGATAATTTGAGGACAGATGAAGAGTCTATTATCGGATCTTCTCAAATTGCGTTGAAGAATATCGATCATTTTGAAGCAAAAAGGGGTGATTTAGTTTGTGTTGTTGGTCGGGTAGGAGCTGGTAAATCAACATTTTTGAAGGCAATTCTTGGTCAACTTCCTTGCATGAGTGGTTCTAGGGACTCGATACCACCTAAACTGATCATTAGATCATCGTCTGTAGCCTACTGTTCACAAGAATCCTGGATAATGAACGCATCTGTAAGAGAAAACATTCTATTTGGTCACAAGTTCGACCAAGATTATTATGACCTCACTATTAAAGCATGTCAATTGCTACCCGATTTGAAAATACTACCAGATGGTGATGAAACTTTGGTAGGTGAAAAGGGCATTTCCCTATCAGGCGGTCAGAAGGCCCGTCTTTCATTAGCCAGAGCGGTGTACTCGAGAGCAGATATTTATTTGTTGGATGACATTTTATCTGCTGTTGATGCAGAAGTTAGTAAAAATATTATTGAATATGTTTTGATCGGAAAGACGGCTTTATTAAAAAATAAAACAATTATTTTAACTACCAATACTGTATCAATTTTAAAACATTCGCAGATGATATATGCGCTAGAAAACGGTGAAATTGTTGAACAAGGGAATTATGAGGATGTAATGAACCGTAAGAACAATACTTCAAAACTGAAAAAATTACTAGAGGAATTTGATTCTCCGATTGATAATGGAAATGAAAGCGATGTCCAAACTGAACACCGATCCGAAAGTGAAGTGGATGAACCTCTGCAGCTTAAAGTAACTGAATCAGAAACTGAGGATGAGGTTGTTACTGAGAGTGAATTAGAACTAATCAAAGCCAATTCTAGAAGAGCTTCTCTAGCTACGCTAAGACCTAGACCCTTTGTGGGAGCACAATTGGATTCCGTGAAGAAAACGGCGCAAAAGGCCGAGAAGACAGAGGTGGGAAGAGTCAAAACAAAGATTTATCTTGCGTATATTAAGGCTTGTGGAGTTTTAGGTGTTGTTTTATTTTTCTTGTTTATGATATTAACAAGGGTTTTCGACTTAGCAGAGAATTTTTGGTTAAAGTACTGGTCAGAATCTAATGAAAAAAATGGTTCAAATGAAAGGGTTTGGATGTTTGTTGGTGTGTATTCCTTAATCGGAGTAGCATCGGCCGCATTCAATAATTTACGGAGTATTATGATGCTACTGTATTGTTCTATTAGGGGTTCTAAGAAACTGCATGAAAGCATGGCCAAATCTGTAATTAGAAGTCCTATGACTTTCTTTGAGACTACACCAGTTGGAAGGATCATAAACAGGTTCTCATCTGATATGGATGCAGTGGACAGTAATCTACAGTACATTTTCTCCTTTTTTTTCAAATCAATACTAACCTATTTGGTTACTGTTATATTAGTCGGGTACAATATGCCATGGTTTTTAGTGTTCAATATGTTTTTGGTGGTTATCTATATTTACTATCAAACATTTTACATTGTGCTATCTAGGGAGCTAAAAAGATTGATCAGTATATCTTACTCTCCGATTATGTCCTTAATGAGTGAGAGCTTGAACGGTTATTCTATTATTGATGCATACGATCATTTTGAGAGATTCATCTATCTAAATTATGAAAAAATCCAATACAACGTTGATTTTGTCTTCAACTTTAGATCAACGAATAGATGGTTATCCGTGAGATTGCAAACTATTGGTGCTACAATTGTTTTGGCTACTGCAATCTTAGCACTAGCAACAATGAATACTAAAAGGCAACTAAGTTCGGGTATGGTTGGTCTACTAATGAGCTATTCATTAGAGGTTACAGGTTCATTGACTTGGATTGTAAGGACAACTGTGACGATTGAAACCAACATTGTATCAGTGGAGAGAATTGTTGAGTACTGCGAATTACCACCTGAAGCACAGTCCATTAACCCTGAAAAGAGGCCAGATGAAAATTGGCCATCAAAGGGTGGTATTGAATTCAAAAACTATTCCACAAAATACAGAGAAAATTTGGATCCAGTGCTGAATAATATTAACGTGAAGATTGAGCCATGTGAAAAGGTTGGGATTGTTGGCAGAACAGGTGCAGGGAAGTCTACACTGAGCCTGGCATTATTTAGAATACTAGAACCTACCGAAGGTAAAATTATTATTGACGGCATTGATATATCCGACATAGGTCTGTTCGATTTAAGAAGCCATTTGGCAATTATTCCTCAGGATGCACAAGCTTTTGAAGGTACAGTAAAGACCAATTTGGACCCTTTCAATCGTTATTCAGAAGATGAACTTAAAAGGGCTGTTGAGCAGGCACATTTAAAGCCTCATCTGGAAAAAATGCTGCACAGTAAACCAAGAGGTGATGATTCTAATGAAGAGGATGGCAATGTTAATGATATTCTGGATGTCAAGATTAATGAGAACGGTAGTAACTTGTCAGTGGGGCAAAGACAACTACTATGTTTGGCAAGAGCGCTGCTAAACCGTTCCAAAATATTGGTCCTTGATGAAGCAACGGCTTCTGTGGATATGGAAACCGATAAAATTATCCAAGACACTATAAGAAGAGAATTTAAGGACCGTACCATCTTAACAATTGCACATCGTATCGACACTGTATTGGACAGTGATAAGATAATTGTTCTTGACCAGGGTAGTGTGAGGGAATTCGATTCACCCTCGAAATTGTTATCCGATAAAACGTCTATTTTTTACAGTCTTTGTGAGAAAGGTGGGTATTTGAAATAA","protein_sequence":"MSSLEVVDGCPYGYRPYPDSGTNALNPCFISVISAWQAVFFLLIGSYQLWKLYKNNKVPPRFKNFPTLPSKINSRHLTHLTNVCFQSTLIICELALVSQSSDRVYPFILKKALYLNLLFNLGISLPTQYLAYFKSTFSMGNQLFYYMFQILLQLFLILQRYYHGSSNERLTVISGQTAMILEVLLLFNSVAIFIYDLCIFEPINELSEYYKKNGWYPPVHVLSYITFIWMNKLIVETYRNKKIKDPNQLPLPPVDLNIKSISKEFKANWELEKWLNRNSLWRAIWKSFGRTISVAMLYETTSDLLSVVQPQFLRIFIDGLNPETSSKYPPLNGVFIALTLFVISVVSVFLTNQFYIGIFEAGLGIRGSLASLVYQKSLRLTLAERNEKSTGDILNLMSVDVLRIQRFFENAQTIIGAPIQIIVVLTSLYWLLGKAVIGGLVTMAIMMPINAFLSRKVKKLSKTQMKYKDMRIKTITELLNAIKSIKLYAWEEPMMARLNHVRNDMELKNFRKIGIVSNLIYFAWNCVPLMVTCSTFGLFSLFSDSPLSPAIVFPSLSLFNILNSAIYSVPSMINTIIETSVSMERLKSFLLSDEIDDSFIERIDPSADERALPAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIALKNIDHFEAKRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGSRDSIPPKLIIRSSSVAYCSQESWIMNASVRENILFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVGEKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKNKTIILTTNTVSILKHSQMIYALENGEIVEQGNYEDVMNRKNNTSKLKKLLEEFDSPIDNGNESDVQTEHRSESEVDEPLQLKVTESETEDEVVTESELELIKANSRRASLATLRPRPFVGAQLDSVKKTAQKAEKTEVGRVKTKIYLAYIKACGVLGVVLFFLFMILTRVFDLAENFWLKYWSESNEKNGSNERVWMFVGVYSLIGVASAAFNNLRSIMMLLYCSIRGSKKLHESMAKSVIRSPMTFFETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKSILTYLVTVILVGYNMPWFLVFNMFLVVIYIYYQTFYIVLSRELKRLISISYSPIMSLMSESLNGYSIIDAYDHFERFIYLNYEKIQYNVDFVFNFRSTNRWLSVRLQTIGATIVLATAILALATMNTKRQLSSGMVGLLMSYSLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQSINPEKRPDENWPSKGGIEFKNYSTKYRENLDPVLNNINVKIEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKIIIDGIDISDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKRAVEQAHLKPHLEKMLHSKPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQLLCLARALLNRSKILVLDEATASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLDQGSVREFDSPSKLLSDKTSIFYSLCEKGGYLK"},{"created_at":"2011-05-27T03:05:12.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Hydroxyacylglutathione hydrolase, mitochondrial","uniprot_id":"Q12320","uniprot_name":"GLO4_YEAST","enzyme":true,"transporter":false,"gene_name":"GLO4","num_residues":285,"molecular_weight":"32338.59961","theoretical_pi":"7.52","general_function":"Involved in hydrolase activity","specific_function":"Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid","reactions":[{"id":1644,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2700,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm","altext":"S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate.","export":false,"pw_reaction_id":null,"source":null},{"id":14118,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006549","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY692965","genbank_protein_id":"51013381","gene_card_id":"GLO4","chromosome_location":"chromosome 15","locus":"YOR040W","synonyms":["Glyoxalase II","Glx II"],"enzyme_classes":["3.1.2.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Lactamase_B","identifier":"PF00753"}],"pathways":[{"name":"Pyruvate metabolism","kegg_map_id":"00620"}],"gene_sequence":"ATGAAGTTTTTACTGCAGCAAATAAGAAATATGCATGTTAAGCCTATAAAAATGCGATGGTTGACAGGTGGTGTCAATTATAGTTATTTACTAAGCACTGAAGACAGGAGAAACTCATGGCTGATTGACCCTGCAGAACCACTTGAGGTGTCGCCAAAATTAAGCGCCGAAGAGAAAAAAAGTATTGATGCTATTGTCAATACACATCACCATTATGACCATTCGGGGGGGAACCTAGCGCTTTATAGTATCTTGTGCCAAGAAAACTCAGGTCACGATATTAAAATAATTGGTGGATCTAAGTCCTCCCCGGGTGTCACTGAAGTACCCGATAATTTGCAGCAGTATCACTTGGGTAACTTAAGAGTAACATGTATTAGGACTCCATGCCATACAAAAGATTCCATATGCTATTATATCAAAGATTTAGAAACAGGTGAGCAGTGCATCTTCACAGGCGACACTTTATTCATTGCCGGTTGTGGGAGGTTTTTCGAGGGCACAGGAAGAGATATGGACATGGCCTTAAACCAGATAATGTTAAGGGCTGTTGGTGAGACGAACTGGAATAAGGTTAAAATATACCCTGGTCATGAGTACACCAAAGGCAATGTTAGCTTTATCAGAGCAAAAATCTATTCCGATATAGGGCAGAACAAGGAGTTTGATGCGTTGGAACAGTATTGCAAATCTAACGAGTGCACCACCGGTCACTTCACCCTGAGAGATGAACTAGGTTATAACCCATTCATGAGATTGGATGATCGTGCCGTTAGACTAGCAGTCGGCGATACTGCTGGGACTTATCCCAGATCCGTAGTGATGCAAGAGTTAAGAAAGCTTAAAAACGCTATGTAA","protein_sequence":"MKFLLQQIRNMHVKPIKMRWLTGGVNYSYLLSTEDRRNSWLIDPAEPLEVSPKLSAEEKKSIDAIVNTHHHYDHSGGNLALYSILCQENSGHDIKIIGGSKSSPGVTEVPDNLQQYHLGNLRVTCIRTPCHTKDSICYYIKDLETGEQCIFTGDTLFIAGCGRFFEGTGRDMDMALNQIMLRAVGETNWNKVKIYPGHEYTKGNVSFIRAKIYSDIGQNKEFDALEQYCKSNECTTGHFTLRDELGYNPFMRLDDRAVRLAVGDTAGTYPRSVVMQELRKLKNAM"},{"created_at":"2011-05-27T03:05:54.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Glutaredoxin-1","uniprot_id":"P25373","uniprot_name":"GLRX1_YEAST","enzyme":true,"transporter":false,"gene_name":"GRX1","num_residues":110,"molecular_weight":"12380.09961","theoretical_pi":"4.72","general_function":"Involved in electron carrier activity","specific_function":"Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage","reactions":[{"id":1584,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X59720","genbank_protein_id":"5328","gene_card_id":"GRX1","chromosome_location":"chromosome 3","locus":"YCL035C","synonyms":["Glutathione-dependent oxidoreductase 1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" disulfide oxidoreductase activity"},{"category":"Function","description":" protein disulfide oxidoreductase activity"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" cell redox homeostasis"}],"pfams":[{"name":"Glutaredoxin","identifier":"PF00462"}],"pathways":[],"gene_sequence":"ATGGTATCTCAAGAAACTATCAAGCACGTCAAGGACCTTATTGCAGAAAACGAGATCTTCGTCGCATCCAAAACGTACTGTCCATACTGCCATGCAGCCCTAAACACGCTTTTTGAAAAGTTAAAGGTTCCCAGGTCCAAAGTTCTGGTTTTGCAATTGAATGACATGAAGGAAGGCGCAGACATTCAGGCTGCGTTATATGAGATTAATGGCCAAAGAACCGTGCCAAACATCTATATTAATGGTAAACATATTGGAGGCAACGACGACTTGCAGGAATTGAGGGAGACTGGTGAATTGGAGGAATTGTTAGAACCTATTCTTGCAAATTAA","protein_sequence":"MVSQETIKHVKDLIAENEIFVASKTYCPYCHAALNTLFEKLKVPRSKVLVLQLNDMKEGADIQAALYEINGQRTVPNIYINGKHIGGNDDLQELRETGELEELLEPILAN"}]}