Glutathione (YMDB00160)

General function:

Involved in glutathione peroxidase activity

Specific function:

May constitute a glutathione peroxidase-like protective system against oxidative stresses

Gene Name:

GPX2

Uniprot ID:

P38143

Molecular weight:

18406.0

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

Gene Name:

GSH2

Uniprot ID:

Q08220

Molecular weight:

55814.69922

Reactions

General function:

Involved in zinc ion binding

Specific function:

Oxidizes long-chain alcohols and, in the presence of glutathione, is able to oxidize formaldehyde. Is responsible for yeast resistance to formaldehyde

Gene Name:

SFA1

Uniprot ID:

P32771

Molecular weight:

41041.69922

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Maintains high levels of reduced glutathione in the cytosol

Gene Name:

GLR1

Uniprot ID:

P41921

Molecular weight:

53440.60156

Reactions

General function:

Involved in glutathione peroxidase activity

Specific function:

May constitute a glutathione peroxidase-like protective system against oxidative stresses

Gene Name:

GPX1

Uniprot ID:

P36014

Molecular weight:

19484.5

Reactions

General function:

Involved in gamma-glutamyltransferase activity

Specific function:

Plays a role in the turnover of the vacuolar glutathione and in the supply of growth requirements during nitrogen starvation

Gene Name:

ECM38

Uniprot ID:

Q05902

Molecular weight:

73179.79688

Reactions

General function:

Posttranslational modification, protein turnover, chaperones

Specific function:

Active as '1-Cys' thiol transferase against beta- hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis

Gene Name:

ECM4

Uniprot ID:

P36156

Molecular weight:

43273.39844

Reactions

General function:

Posttranslational modification, protein turnover, chaperones

Specific function:

Active as '1-Cys' thiol transferase against beta- hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB)

Gene Name:

GTO3

Uniprot ID:

Q04806

Molecular weight:

42402.60156

Reactions

General function:

Involved in protein binding

Specific function:

RX + glutathione = HX + R-S-glutathione

Gene Name:

GTT2

Uniprot ID:

Q12390

Molecular weight:

26339.40039

Reactions

General function:

Involved in hydrolase activity

Specific function:

Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid

Gene Name:

GLO2

Uniprot ID:

Q05584

Molecular weight:

31326.30078

Reactions

General function:

Posttranslational modification, protein turnover, chaperones

Specific function:

Active as '1-Cys' thiol transferase against beta- hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB)

Gene Name:

GTO1

Uniprot ID:

P48239

Molecular weight:

41300.19922

Reactions

General function:

Involved in electron carrier activity

Specific function:

Monothiol glutaredoxin involved in iron-sulfur biogenesis. Required for normal iron homeostasis. Protects cells against oxidative damage due to reactive oxygen species

Gene Name:

GRX5

Uniprot ID:

Q02784

Molecular weight:

16931.30078

Reactions

General function:

Involved in glutathione peroxidase activity

Specific function:

Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator YAP1, which is involved in transcription activation of genes of the oxidative stress response pathway. May also play a direct role in hydroperoxide scavenging, being the most active of three closely related S.cerevisiae peroxiredoxins (GPX1, GPX2, and HYP1/GPX3) with respect to peroxide and lipid hydroperoxide reduction. The three enzymes are not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, HYP1 is directly oxidized at Cys-36 to form a cysteine sulfenic acid (-SOH). Cys-36-SOH then forms either an intramolecular disulfide bond (Cys-36 with Cys-82) or a transient, intermolecular disulfide bond with 'Cys-598' of YAP1, which is further resolved into a YAP1 intramolecular disulfide bond ('Cys-303' with 'Cys-598') and a reduced Cys-36 in HYP1/GPX3

Gene Name:

HYR1

Uniprot ID:

P40581

Molecular weight:

18641.40039

Reactions

General function:

Involved in protein binding

Specific function:

RX + glutathione = HX + R-S-glutathione

Gene Name:

GTT1

Uniprot ID:

P40582

Molecular weight:

26794.5

Reactions

General function:

Involved in electron carrier activity

Specific function:

Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage

Gene Name:

GRX2

Uniprot ID:

P17695

Molecular weight:

15861.2998

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Serine hydrolase involved in the detoxification of formaldehyde

Gene Name:

Not Available

Uniprot ID:

P40363

Molecular weight:

33934.0

Reactions

General function:

Involved in lactoylglutathione lyase activity

Specific function:

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione

Gene Name:

GLO1

Uniprot ID:

P50107

Molecular weight:

37208.69922

Reactions

General function:

Involved in electron carrier activity

Specific function:

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (Probable)

Gene Name:

GRX4

Uniprot ID:

P32642

Molecular weight:

27492.59961

General function:

Involved in hydrolase activity

Specific function:

Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid

Gene Name:

GLO4

Uniprot ID:

Q12320

Molecular weight:

32338.59961

Reactions

General function:

Involved in electron carrier activity

Specific function:

Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage

Gene Name:

GRX1

Uniprot ID:

P25373

Molecular weight:

12380.09961

Reactions