{"ymdb_id":"YMDB00518","created_at":"2011-05-29T18:25:56.000Z","updated_at":"2016-09-08T18:35:34.000Z","name":"5-Methyltetrahydropteroyltri-L-glutamic acid","cas":null,"state":"Solid","melting_point":null,"description":"5-Methyltetrahydropteroyltri-L-glutamate is formed under reaction between carbonyl group of 5-methyltetrahydropteroate and amine group on one end of three replicates of glutamate. It is involved in several pathways such as tetrahydrofolate biosynthesis and methionine biosynthesis.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"Cytoplasm","synthesis_reference":null,"chebi_id":"17614","hmdb_id":"HMDB12177","kegg_id":"C04489","pubchem_id":"16722111","cs_id":"17625689","foodb_id":null,"wikipedia_link":null,"biocyc_id":"CPD-1302","iupac":"(2S)-2-[(4S)-4-[(4S)-4-{[4-({[(6S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}-4-carboxybutanamido]-4-carboxybutanamido]pentanedioic acid","traditional_iupac":"(2S)-2-[(4S)-4-[(4S)-4-{[4-({[(6S)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methyl}amino)phenyl]formamido}-4-carboxybutanamido]-4-carboxybutanamido]pentanedioic acid","logp":"-3.8712439774221754","pka":"3.5152608229389233","alogps_solubility":"3.54e-01 g/l","alogps_logp":"-1.41","alogps_logs":"-3.31","acceptor_count":"18","donor_count":"11","rotatable_bond_count":"19","polar_surface_area":"331.28","refractivity":"182.8569000000001","polarizability":"70.6751472183955","formal_charge":"0","physiological_charge":"-4","pka_strongest_basic":"3.1444830824341894","pka_strongest_acidic":"2.6922397908981113","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["5-Methyltetrahydropteroyltri-L-glutamate","5-methyltetrahydropteroyltri-L-glutamic acid"],"pathways":[{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Selenocompound metabolism","kegg_map_id":"00450"}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":3542720,"citation":"Csaikl, U., Csaikl, F. (1986). \"Molecular cloning and characterization of the MET6 gene of Saccharomyces cerevisiae.\" Gene 46:207-214."},{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."}],"proteins":[{"created_at":"2011-05-26T17:54:29.000Z","updated_at":"2011-07-22T17:53:51.000Z","name":"5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase","uniprot_id":"P05694","uniprot_name":"METE_YEAST","enzyme":true,"transporter":false,"gene_name":"MET6","num_residues":767,"molecular_weight":"85859.20313","theoretical_pi":"6.41","general_function":"Involved in 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity","specific_function":"Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation","reactions":[{"id":1218,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1729,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2494,"direction":"\u003e","locations":null,"altext":"5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.","export":false,"pw_reaction_id":null,"source":null},{"id":3784,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006306","source":"Smpdb"},{"id":3785,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006776","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"DQ393811","genbank_protein_id":"88910023","gene_card_id":"MET6","chromosome_location":"chromosome 5","locus":"YER091C","synonyms":["Cobalamin-independent methionine synthase","Delta-P8 protein","Methionine synthase, vitamin-B12 independent isozyme"],"enzyme_classes":["2.1.1.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" S-methyltransferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" sulfur amino acid metabolic process"},{"category":"Process","description":" sulfur amino acid biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" methionine biosynthetic process"}],"pfams":[{"name":"Meth_synt_1","identifier":"PF08267"},{"name":"Meth_synt_2","identifier":"PF01717"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Selenocompound metabolism","kegg_map_id":"00450"}],"gene_sequence":"ATGGTTCAATCTGCTGTCTTAGGGTTCCCAAGAATCGGTCCAAACAGAGAATTAAAGAAGGCCACTGAAGGTTACTGGAACGGTAAAATCACTGTCGATGAATTATTCAAGGTCGGTAAGGATTTGAGAACTCAAAACTGGAAGTTGCAAAAGGAGGCTGGTGTTGATATCATCCCATCCAATGACTTCTCCTTTTACGACCAAGTTTTGGATTTGTCTTTGTTGTTCAATGTCATTCCAGACCGTTACACTAAGTACGATCTATCTCCAATCGACACTTTGTTTGCTATGGGTAGAGGTTTACAAAGAAAGGCCACTGAAACTGAAAAGGCTGTCGACGTCACTGCTTTGGAAATGGTTAAATGGTTCGACTCTAACTACCATTACGTTAGACCAACTTTCTCCAAGACCACTCAATTTAAGTTGAACGGCCAAAAGCCAGTTGACGAATTTTTGGAAGCCAAGGAGTTAGGTATTCATACTAGACCTGTCTTGTTGGGTCCAGTTTCTTACTTATTCTTGGGTAAGGCTGACAAGGATTCTCTAGATTTGGAACCATTGTCCCTATTGGAACAATTGTTGCCTCTATACACTGAAATCCTATCTAAATTGGCTTCTGCTGGTGCCACTGAAGTTCAAATTGACGAACCTGTCTTAGTTTTGGACTTGCCTGCCAACGCCCAAGCCGCCATTAAGAAGGCTTACACTTACTTCGGTGAACAAAGCAATCTACCAAAGATTACTTTGGCTACTTACTTCGGTACCGTTGTCCCTAACTTAGACGCCATCAAGGGCTTGCCAGTTGCTGCCTTACACGTTGACTTTGTTAGAGCTCCAGAACAATTTGATGAAGTCGTTGCCGCCATTGGTAACAAACAAACCTTGTCTGTTGGTATTGTTGATGGTAGAAACATTTGGAAGAATGATTTCAAGAAGTCTTCCGCTATCGTTAACAAGGCTATTGAAAAGTTGGGTGCTGACAGAGTCGTTGTTGCCACTTCTTCTTCTCTATTGCACACACCAGTTGATTTGAACAACGAAACCAAGTTGGACGCTGAAATCAAGGGCTTTTTCTCTTTCGCCACTCAAAAATTGGATGAAGTTGTTGTGATCACCAAGAACGTTTCCGGTCAAGACGTTGCTGCTGCCCTAGAAGCTAACGCTAAATCTGTTGAATCCAGAGGTAAATCCAAGTTTATCCACGATGCTGCCGTTAAGGCCAGAGTTGCCTCTATCGACGAAAAAATGTCTACTAGAGCAGCTCCATTTGAACAAAGATTGCCTGAACAACAAAAAGTCTTCAACTTGCCATTGTTCCCAACAACAACTATTGGTTCCTTCCCTCAAACCAAGGACATCAGAATTAACAGAAACAAATTCAACAAGGGTACCATCTCTGCTGAAGAATATGAAAAATTCATCAATTCTGAAATTGAAAAGGTCATCAGATTCCAAGAAGAAATTGGTTTGGATGTCTTAGTCCACGGTGAACCAGAAAGAAACGATATGGTTCAATACTTCGGTGAACAAATCAACGGTTATGCTTTCACTGTTAACGGTTGGGTTCAATCTTACGGTTCCAGATATGTCAGACCACCAATTATTGTTGGTGACTTGTCCAGACCAAAGGCTATGTCCGTCAAGGAATCTGTTTACGCTCAATCCATCACTTCTAAGCCAGTAAAGGGTATGTTGACTGGTCCAATTACCTGTTTGAGATGGTCTTTCCCAAGAGACGATGTCGACCAAAAAACTCAAGCTATGCAATTAGCTTTGGCTTTGAGAGATGAAGTCAATGATTTGGAAGCTGCCGGTATCAAGGTTATCCAAGTTGATGAACCAGCTTTAAGAGAAGGTTTACCATTGAGAGAAGGTACTGAGAGATCTGCTTACTACACCTGGGCTGCCGAAGCTTTCAGAGTTGCTACTTCTGGTGTTGCTAACAAGACTCAAATACACTCTCATTTCTGTTACTCTGACTTGGATCCAAACCATATCAAGGCTTTGGATGCTGATGTTGTTTCCATCGAATTCTCTAAGAAGGACGATGCTAACTACATTGCTGAATTCAAAAACTATCCAAACCACATTGGTCTAGGTTTATTCGATATTCATTCTCCAAGAATTCCATCAAAGGATGAATTTATCGCCAAGATTTCAACCATCTTGAAGAGCTACCCAGCTGAAAAGTTCTGGGTTAACCCAGATTGTGGTTTGAAGACTAGAGGCTGGGAAGAAACTAGATTGTCTTTGACTCATATGGTCGAAGCCGCCAAGTACTTCCGTGAACAATACAAGAATTAA","protein_sequence":"MVQSAVLGFPRIGPNRELKKATEGYWNGKITVDELFKVGKDLRTQNWKLQKEAGVDIIPSNDFSFYDQVLDLSLLFNVIPDRYTKYDLSPIDTLFAMGRGLQRKATETEKAVDVTALEMVKWFDSNYHYVRPTFSKTTQFKLNGQKPVDEFLEAKELGIHTRPVLLGPVSYLFLGKADKDSLDLEPLSLLEQLLPLYTEILSKLASAGATEVQIDEPVLVLDLPANAQAAIKKAYTYFGEQSNLPKITLATYFGTVVPNLDAIKGLPVAALHVDFVRAPEQFDEVVAAIGNKQTLSVGIVDGRNIWKNDFKKSSAIVNKAIEKLGADRVVVATSSSLLHTPVDLNNETKLDAEIKGFFSFATQKLDEVVVITKNVSGQDVAAALEANAKSVESRGKSKFIHDAAVKARVASIDEKMSTRAAPFEQRLPEQQKVFNLPLFPTTTIGSFPQTKDIRINRNKFNKGTISAEEYEKFINSEIEKVIRFQEEIGLDVLVHGEPERNDMVQYFGEQINGYAFTVNGWVQSYGSRYVRPPIIVGDLSRPKAMSVKESVYAQSITSKPVKGMLTGPITCLRWSFPRDDVDQKTQAMQLALALRDEVNDLEAAGIKVIQVDEPALREGLPLREGTERSAYYTWAAEAFRVATSGVANKTQIHSHFCYSDLDPNHIKALDADVVSIEFSKKDDANYIAEFKNYPNHIGLGLFDIHSPRIPSKDEFIAKISTILKSYPAEKFWVNPDCGLKTRGWEETRLSLTHMVEAAKYFREQYKN"}]}