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S-Adenosylmethionine (YMDB00297)
| Identification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| YMDB ID | YMDB00297 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Name | S-Adenosylmethionine | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Saccharomyces cerevisiae | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strain | Baker's yeast | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | S-Adenosylmethionine, also known as SAM or adomet, belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group. S-Adenosylmethionine is a very strong basic compound (based on its pKa). S-Adenosylmethionine exists in all living species, ranging from bacteria to humans. S-Adenosylmethionine is a potentially toxic compound. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Structure |  | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms |
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| CAS number | 29908-03-0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Weight | Average: 399.445 Monoisotopic: 399.145063566 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InChI Key | MEFKEPWMEQBLKI-XCPQSEKJSA-O | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InChI | InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8-,10-,11-,14-,27?/m1/s1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IUPAC Name | [(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Traditional IUPAC Name | SAMe | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical Formula | C15H23N6O5S | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SMILES | [H]OC(=O)[C@]([H])(N([H])[H])C([H])([H])C([H])([H])[S+](C([H])([H])[H])C([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical Taxonomy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kingdom | Organic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Super Class | Nucleosides, nucleotides, and analogues | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Class | 5'-deoxyribonucleosides | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sub Class | 5'-deoxy-5'-thionucleosides | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Direct Parent | 5'-deoxy-5'-thionucleosides | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Alternative Parents |
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| Substituents |
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| Molecular Framework | Aromatic heteropolycyclic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| External Descriptors |
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| Physical Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| State | Solid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Charge | 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Melting point | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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| Biological Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cellular Locations |
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| Organoleptic Properties | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SMPDB Pathways |
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| KEGG Pathways |
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| SMPDB Reactions | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KEGG Reactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Intracellular Concentrations | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Extracellular Concentrations | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spectra |
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| References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| References: |
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| Synthesis Reference: | Lin, Jian-Ping; Tian, Jun; You, Jian-Feng; Jin, Zhi-Hua; Xu, Zhi-Nan; Cen, Pei-Lin. An effective strategy for the co-production of S-adenosyl-L-methionine and glutathione by fed-batch fermentation. Biochemical Engineering Journal (2004), 21(1), 19-25. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| External Links: |
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Enzymes
- General function:
- Involved in methyltransferase activity
- Specific function:
- Required for the methylation step in diphthamide biosynthesis
- Gene Name:
- DPH5
- Uniprot ID:
- P32469
- Molecular weight:
- 33847.0
Reactions
| 3 S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine → 3 S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(trimethylammonio)propyl)-L-histidine. |
- General function:
- Involved in methyltransferase activity
- Specific function:
- Siroheme synthase involved in methionine biosynthesis
- Gene Name:
- MET1
- Uniprot ID:
- P36150
- Molecular weight:
- 66124.70313
Reactions
| S-adenosyl-L-methionine + uroporphyrinogen III → S-adenosyl-L-homocysteine + precorrin-1. |
| S-adenosyl-L-methionine + precorrin-1 → S-adenosyl-L-homocysteine + precorrin-2. |
- General function:
- Involved in methyltransferase activity
- Specific function:
- Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway
- Gene Name:
- COQ3
- Uniprot ID:
- P27680
- Molecular weight:
- 36330.60156
Reactions
| S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate → S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate. |
| S-adenosyl-L-methionine + 3-demethylubiquinone-n → S-adenosyl-L-homocysteine + ubiquinone-n. |
| S-adenosyl-L-methionine + 2-hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol → S-adenosyl-L-homocysteine + ubiquinol. |
- General function:
- Involved in catalytic activity
- Specific function:
- Dethiobiotin + sulfur + 2 S-adenosyl-L- methionine = biotin + 2 L-methionine + 2 5'-deoxyadenosine
- Gene Name:
- BIO2
- Uniprot ID:
- P32451
- Molecular weight:
- 41883.80078
Reactions
| Dethiobiotin + sulfur + 2 S-adenosyl-L-methionine → biotin + 2 L-methionine + 2 5'-deoxyadenosine. |
- General function:
- Involved in transaminase activity
- Specific function:
- Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor
- Gene Name:
- BIO3
- Uniprot ID:
- P50277
- Molecular weight:
- 53708.39844
Reactions
| S-adenosyl-L-methionine + 8-amino-7-oxononanoate → S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate. |
- General function:
- Involved in methionine adenosyltransferase activity
- Specific function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP
- Gene Name:
- SAM1
- Uniprot ID:
- P10659
- Molecular weight:
- 41818.0
Reactions
| ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine. |
- General function:
- Involved in catalytic activity
- Specific function:
- Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (Probable)
- Gene Name:
- LIP5
- Uniprot ID:
- P32875
- Molecular weight:
- 46246.80078
Reactions
| Protein N(6)-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine → protein N(6)-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosine. |
- General function:
- Involved in methyltransferase activity
- Specific function:
- Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation
- Gene Name:
- TMT1
- Uniprot ID:
- P32643
- Molecular weight:
- 34768.0
Reactions
| S-adenosyl-L-methionine + trans-aconitate → S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate. |
- General function:
- Involved in adenosylmethionine decarboxylase activity
- Specific function:
- S-adenosylmethionine decarboxylase is essential for normal growth, sporulation, maintenance of ds-RNA virus, biosynthesis of spermine and spermidine
- Gene Name:
- SPE2
- Uniprot ID:
- P21182
- Molecular weight:
- 46232.0
Reactions
| S-adenosyl-L-methionine → (5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO(2). |
- General function:
- Involved in methyltransferase activity
- Specific function:
- Converts DDMQH2 into DMQH2
- Gene Name:
- COQ5
- Uniprot ID:
- P49017
- Molecular weight:
- 34684.19922
Reactions
| S-adenosyl-L-methionine + 2-polyprenyl-6-methoxy-1,4-benzoquinol → S-adenosyl-L-homocysteine + 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol. |
- General function:
- Involved in methyltransferase activity
- Specific function:
- tRNA (uracil-O(2)-)-methyltransferase, which catalyzes the formation of O(2)-methyluracil at position 44 (m2U44) in tRNA(Ser)
- Gene Name:
- TRM44
- Uniprot ID:
- Q02648
- Molecular weight:
- 64854.60156
Reactions
| S-adenosyl-L-methionine + uridine(44) in tRNA → S-adenosyl-L-homocysteine + 2'-O-methyluridine(44) in tRNA. |
- General function:
- Involved in [cytochrome c]-lysine N-methyltransferase a
- Specific function:
- Methyltransferase which mediates trimethylation of Lys- 77 of cytochrome c (CYC1)
- Gene Name:
- CTM1
- Uniprot ID:
- P38818
- Molecular weight:
- 68283.60156
Reactions
| S-adenosyl-L-methionine + [cytochrome c]-L-lysine → S-adenosyl-L-homocysteine + [cytochrome c]-N(6)-methyl-L-lysine. |
- General function:
- Involved in methyltransferase activity
- Specific function:
- N6-methyltransferase that methylates adenosine residues of some mRNAs and is essential to activate sporulation. N6- methyladenosine (m6A), which is present at internal sites of some mRNAs, is probably required to initiate sporulation. Positive regulator for IME2
- Gene Name:
- IME4
- Uniprot ID:
- P41833
- Molecular weight:
- 69395.39844
Reactions
| S-adenosyl-L-methionine + m(7)G(5')pppAm → S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am. |
- General function:
- Involved in methyltransferase activity
- Specific function:
- Catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNAs
- Gene Name:
- TRM10
- Uniprot ID:
- Q12400
- Molecular weight:
- 34520.19922
Reactions
| S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing N(1)-methylguanine. |
- General function:
- Involved in tRNA (adenine-N1-)-methyltransferase activity
- Specific function:
- Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. GCD14 is also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency
- Gene Name:
- GCD14
- Uniprot ID:
- P46959
- Molecular weight:
- 43919.30078
Reactions
| S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing N(1)-methyladenine. |
- General function:
- Involved in RNA binding
- Specific function:
- Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Required for the modification of both mitochondrial and cytoplasmic tRNAs
- Gene Name:
- TRM1
- Uniprot ID:
- P15565
- Molecular weight:
- 64051.80078
Reactions
| S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing N(2)-methylguanine. |
- General function:
- Involved in RNA binding
- Specific function:
- Methylates cytosine to m5C at several positions in different tRNAs and pre-tRNAs containing intron. Able to modify tRNAs at all four positions (34, 40, 48 and 49) at which m5C has been found in tRNAs. May be involved in ribosome biogenesis as its disruption leads to increased sensitivity to the antibiotic paromomycin
- Gene Name:
- NCL1
- Uniprot ID:
- P38205
- Molecular weight:
- 77878.0
Reactions
| S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine. |
- General function:
- Involved in protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
- Specific function:
- Mediates C-terminal methylation of the isoprenylated C- terminal cysteine in A-factor mating pheromone and Ras proteins
- Gene Name:
- STE14
- Uniprot ID:
- P32584
- Molecular weight:
- 27887.40039
Reactions
| S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine → S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. |
- General function:
- Involved in methyltransferase activity
- Specific function:
- Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
- Gene Name:
- TRM7
- Uniprot ID:
- P38238
- Molecular weight:
- 34700.19922
Reactions
| S-adenosyl-L-methionine + rRNA → S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine. |
- General function:
- Involved in methyltransferase activity
- Specific function:
- Catalyzes the two serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylates the m3G cap on TLC1 telomerase which affects telomere silencing and telomere length regulation. Required for pre-mRNA splicing, pre-rRNA processing and small ribosomal subunit synthesis. Involved in nucleolar structural organization
- Gene Name:
- TGS1
- Uniprot ID:
- Q12052
- Molecular weight:
- 36526.80078
Reactions
| S-adenosyl-L-methionine + m(7)G(5')pppR-RNA → S-adenosyl-L-homocysteine + m(2,7)G(5')pppR-RNA. |
| S-adenosyl-L-methionine + m(2,7)G(5')pppR-RNA → S-adenosyl-L-homocysteine + m(2,2,7)G(5')pppR-RNA. |
- General function:
- Involved in RNA binding
- Specific function:
- Specifically methylates guanosine-18 in various tRNAs
- Gene Name:
- TRM3
- Uniprot ID:
- Q07527
- Molecular weight:
- 165046.0
Reactions
| S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine. |
- General function:
- Involved in methyltransferase activity
- Specific function:
- Specifically methylates guanosine-4 in various tRNAs with a Gly(CCG), His or Pro signature
- Gene Name:
- TRM13
- Uniprot ID:
- Q12383
- Molecular weight:
- 54094.5
Reactions
| S-adenosyl-L-methionine + rRNA → S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine. |
- General function:
- Involved in methyltransferase activity
- Specific function:
- Involved in the control of the cell cycle at the G2/M (mitosis) transition. Cooperates with HSL1 to hyperphosphorylate SWE1, thereby targeting SWE1 for polyubiquitination and subsequent degradation. Acts as a negative regulator of the filamentous growth-signaling pathway through inhibition of STE20
- Gene Name:
- HSL7
- Uniprot ID:
- P38274
- Molecular weight:
- 95152.5
Reactions
| S-adenosyl-L-methionine + arginine-[histone] → S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone]. |
- General function:
- Involved in methyltransferase activity
- Specific function:
- Specifically methylates the uridine in position 2791 of mitochondrial 21S rRNA in the fully assembled mitochondrial large ribosomal subunit
- Gene Name:
- MRM2
- Uniprot ID:
- P53123
- Molecular weight:
- 37423.10156
Reactions
| S-adenosyl-L-methionine + uridine(2791)-2'-O in 21S rRNA → S-adenosyl-L-homocysteine + 2'-O-methyluridine(2791)-2'-O in 21S rRNA. |
- General function:
- Involved in tRNA (guanine-N7-)-methyltransferase activity
- Specific function:
- Methyltransferase that catalyzes the formation of N(7)- methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity
- Gene Name:
- TRM8
- Uniprot ID:
- Q12009
- Molecular weight:
- 33391.19922
Reactions
| S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing N(7)-methylguanine. |
- General function:
- Involved in nicotinamide N-methyltransferase activity
- Specific function:
- Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination
- Gene Name:
- NNT1
- Uniprot ID:
- Q05874
- Molecular weight:
- 29632.30078
Reactions
| S-adenosyl-L-methionine + nicotinamide → S-adenosyl-L-homocysteine + 1-methylnicotinamide. |
- General function:
- Involved in phosphatidylethanolamine N-methyltransferas
- Specific function:
- S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
- Gene Name:
- PEM1
- Uniprot ID:
- P05374
- Molecular weight:
- 101203.0
Reactions
| S-adenosyl-L-methionine + phosphatidylethanolamine → S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine. |
- General function:
- Involved in identical protein binding
- Specific function:
- Specifically methylates guanosine-37 in various tRNAs. Not dependent on the nature of the nucleoside 5' of the target nucleoside
- Gene Name:
- TRM5
- Uniprot ID:
- P38793
- Molecular weight:
- 56514.0
Reactions
| S-adenosyl-L-methionine + tRNA → S-adenosyl-L-homocysteine + tRNA containing N(1)-methylguanine. |
- General function:
- Involved in N-methyltransferase activity
- Specific function:
- S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid
- Gene Name:
- OPI3
- Uniprot ID:
- P05375
- Molecular weight:
- 23150.09961
Reactions
| S-adenosyl-L-methionine + phospholipid olefinic fatty acid → S-adenosyl-L-homocysteine + phospholipid methylene fatty acid. |
- General function:
- Involved in methyltransferase activity
- Specific function:
- Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation. Methylates also the uridine in position 2921 in the absence of methylation of this residue guided by snoRNA snR52 at the stage of 35S pre-rRNA maturation
- Gene Name:
- SPB1
- Uniprot ID:
- P25582
- Molecular weight:
- 96484.0
Reactions
| S-adenosyl-L-methionine + rRNA → S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine. |
| S-adenosyl-L-methionine + rRNA → S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine. |
- General function:
- Involved in methyltransferase activity
- Specific function:
- Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol
- Gene Name:
- ERG6
- Uniprot ID:
- P25087
- Molecular weight:
- 43430.5
Reactions
| S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol → S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol. |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP
- Gene Name:
- SAM2
- Uniprot ID:
- P19358
- Molecular weight:
- 42255.5
Reactions
| ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine. |
- General function:
- Involved in RNA methyltransferase activity
- Specific function:
- Catalyzes the formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNA. May also have a role in tRNA stabilization or maturation
- Gene Name:
- TRM2
- Uniprot ID:
- P33753
- Molecular weight:
- 72851.79688
Reactions
| S-adenosyl-L-methionine + tRNA containing uridine at position 54 → S-adenosyl-L-homocysteine + tRNA containing ribothymidine at position 54. |