{"ymdb_id":"YMDB00238","created_at":"2011-05-29T16:10:12.000Z","updated_at":"2016-09-08T18:35:13.000Z","name":"5-Methyltetrahydrofolic acid","cas":"134-35-0","state":"Solid","melting_point":"","description":"5-Methyltetrahydrofolic acid (5-MTHF) is the most biologically active form of the B-vitamin folic acid, also known generically as folate. 5-MTHF functions, in concert with vitamin B12, as a methyl-group donor involved in the conversion of the amino acid homocysteine to methionine.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":"Gennari, Federico.  Process for producing 5-methyltetrahydrofolic acid and its salts.    U.S.  (1992),     6 pp.","chebi_id":"15641","hmdb_id":"HMDB01396","kegg_id":"C00440","pubchem_id":"439234","cs_id":"388371","foodb_id":null,"wikipedia_link":"5-Methyltetrahydrofolate","biocyc_id":"5-METHYL-THF","iupac":"(2R)-2-[(4-{[(2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid","traditional_iupac":"(2R)-2-[(4-{[(2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid","logp":"-2.843842352810261","pka":"3.8684582575504742","alogps_solubility":"3.46e-01 g/l","alogps_logp":"-1.26","alogps_logs":"-3.12","acceptor_count":"11","donor_count":"7","rotatable_bond_count":"9","polar_surface_area":"198.47999999999996","refractivity":"126.88129999999997","polarizability":"46.12606690283296","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"4.637989856477614","pka_strongest_acidic":"3.2189752579192654","bioavailability":"0","number_of_rings":"3","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["(6S)-5-methyltetrahydrofolate","[(6S)-5-methyl-5,6,7,8-tetrahydropteroyl]glutamate","5-Methyl tetrahydrofolate","5-methyl-5,6,7,8-tetrahydrofolate","5-methyl-tetrahydrofolate","5-Methyltetrahydrofolate","5-Methyltetrahydropteroylglutamate","Methyl folate","methyl-tetrahydrofolate","N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-Glutamate","N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-Glutamic acid","N-(5-methyl-5,6,7,8-tetrahydropteroyl)-L-glutamate","N-(5-methyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid","N( 5)-Methyltetrahydrofolate","N5-Methyl-tetrahydrofolate","N5-Methyl-tetrahydrofolic acid","N5-methyltetrahydrofolate","N5-methyltetrahydropteroyl mono-L-glutamate"],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"One Carbon Pool by Folate I","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":16083849,"citation":"Suliman, H. S., Sawyer, G. M., Appling, D. R., Robertus, J. D. (2005). \"Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae.\" Arch Biochem Biophys 441:56-63."}],"proteins":[{"created_at":"2011-05-26T17:54:29.000Z","updated_at":"2011-07-22T17:53:51.000Z","name":"5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase","uniprot_id":"P05694","uniprot_name":"METE_YEAST","enzyme":true,"transporter":false,"gene_name":"MET6","num_residues":767,"molecular_weight":"85859.20313","theoretical_pi":"6.41","general_function":"Involved in 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity","specific_function":"Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation","reactions":[{"id":1218,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1729,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2494,"direction":"\u003e","locations":null,"altext":"5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.","export":false,"pw_reaction_id":null,"source":null},{"id":3784,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006306","source":"Smpdb"},{"id":3785,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006776","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"DQ393811","genbank_protein_id":"88910023","gene_card_id":"MET6","chromosome_location":"chromosome 5","locus":"YER091C","synonyms":["Cobalamin-independent methionine synthase","Delta-P8 protein","Methionine synthase, vitamin-B12 independent isozyme"],"enzyme_classes":["2.1.1.14"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" S-methyltransferase activity"},{"category":"Function","description":" transferase activity, transferring one-carbon groups"},{"category":"Function","description":" 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"},{"category":"Function","description":" methyltransferase activity"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" sulfur amino acid metabolic process"},{"category":"Process","description":" sulfur amino acid biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" methionine biosynthetic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"Meth_synt_1","identifier":"PF08267"},{"name":"Meth_synt_2","identifier":"PF01717"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"Selenocompound metabolism","kegg_map_id":"00450"}],"gene_sequence":"ATGGTTCAATCTGCTGTCTTAGGGTTCCCAAGAATCGGTCCAAACAGAGAATTAAAGAAGGCCACTGAAGGTTACTGGAACGGTAAAATCACTGTCGATGAATTATTCAAGGTCGGTAAGGATTTGAGAACTCAAAACTGGAAGTTGCAAAAGGAGGCTGGTGTTGATATCATCCCATCCAATGACTTCTCCTTTTACGACCAAGTTTTGGATTTGTCTTTGTTGTTCAATGTCATTCCAGACCGTTACACTAAGTACGATCTATCTCCAATCGACACTTTGTTTGCTATGGGTAGAGGTTTACAAAGAAAGGCCACTGAAACTGAAAAGGCTGTCGACGTCACTGCTTTGGAAATGGTTAAATGGTTCGACTCTAACTACCATTACGTTAGACCAACTTTCTCCAAGACCACTCAATTTAAGTTGAACGGCCAAAAGCCAGTTGACGAATTTTTGGAAGCCAAGGAGTTAGGTATTCATACTAGACCTGTCTTGTTGGGTCCAGTTTCTTACTTATTCTTGGGTAAGGCTGACAAGGATTCTCTAGATTTGGAACCATTGTCCCTATTGGAACAATTGTTGCCTCTATACACTGAAATCCTATCTAAATTGGCTTCTGCTGGTGCCACTGAAGTTCAAATTGACGAACCTGTCTTAGTTTTGGACTTGCCTGCCAACGCCCAAGCCGCCATTAAGAAGGCTTACACTTACTTCGGTGAACAAAGCAATCTACCAAAGATTACTTTGGCTACTTACTTCGGTACCGTTGTCCCTAACTTAGACGCCATCAAGGGCTTGCCAGTTGCTGCCTTACACGTTGACTTTGTTAGAGCTCCAGAACAATTTGATGAAGTCGTTGCCGCCATTGGTAACAAACAAACCTTGTCTGTTGGTATTGTTGATGGTAGAAACATTTGGAAGAATGATTTCAAGAAGTCTTCCGCTATCGTTAACAAGGCTATTGAAAAGTTGGGTGCTGACAGAGTCGTTGTTGCCACTTCTTCTTCTCTATTGCACACACCAGTTGATTTGAACAACGAAACCAAGTTGGACGCTGAAATCAAGGGCTTTTTCTCTTTCGCCACTCAAAAATTGGATGAAGTTGTTGTGATCACCAAGAACGTTTCCGGTCAAGACGTTGCTGCTGCCCTAGAAGCTAACGCTAAATCTGTTGAATCCAGAGGTAAATCCAAGTTTATCCACGATGCTGCCGTTAAGGCCAGAGTTGCCTCTATCGACGAAAAAATGTCTACTAGAGCAGCTCCATTTGAACAAAGATTGCCTGAACAACAAAAAGTCTTCAACTTGCCATTGTTCCCAACAACAACTATTGGTTCCTTCCCTCAAACCAAGGACATCAGAATTAACAGAAACAAATTCAACAAGGGTACCATCTCTGCTGAAGAATATGAAAAATTCATCAATTCTGAAATTGAAAAGGTCATCAGATTCCAAGAAGAAATTGGTTTGGATGTCTTAGTCCACGGTGAACCAGAAAGAAACGATATGGTTCAATACTTCGGTGAACAAATCAACGGTTATGCTTTCACTGTTAACGGTTGGGTTCAATCTTACGGTTCCAGATATGTCAGACCACCAATTATTGTTGGTGACTTGTCCAGACCAAAGGCTATGTCCGTCAAGGAATCTGTTTACGCTCAATCCATCACTTCTAAGCCAGTAAAGGGTATGTTGACTGGTCCAATTACCTGTTTGAGATGGTCTTTCCCAAGAGACGATGTCGACCAAAAAACTCAAGCTATGCAATTAGCTTTGGCTTTGAGAGATGAAGTCAATGATTTGGAAGCTGCCGGTATCAAGGTTATCCAAGTTGATGAACCAGCTTTAAGAGAAGGTTTACCATTGAGAGAAGGTACTGAGAGATCTGCTTACTACACCTGGGCTGCCGAAGCTTTCAGAGTTGCTACTTCTGGTGTTGCTAACAAGACTCAAATACACTCTCATTTCTGTTACTCTGACTTGGATCCAAACCATATCAAGGCTTTGGATGCTGATGTTGTTTCCATCGAATTCTCTAAGAAGGACGATGCTAACTACATTGCTGAATTCAAAAACTATCCAAACCACATTGGTCTAGGTTTATTCGATATTCATTCTCCAAGAATTCCATCAAAGGATGAATTTATCGCCAAGATTTCAACCATCTTGAAGAGCTACCCAGCTGAAAAGTTCTGGGTTAACCCAGATTGTGGTTTGAAGACTAGAGGCTGGGAAGAAACTAGATTGTCTTTGACTCATATGGTCGAAGCCGCCAAGTACTTCCGTGAACAATACAAGAATTAA","protein_sequence":"MVQSAVLGFPRIGPNRELKKATEGYWNGKITVDELFKVGKDLRTQNWKLQKEAGVDIIPSNDFSFYDQVLDLSLLFNVIPDRYTKYDLSPIDTLFAMGRGLQRKATETEKAVDVTALEMVKWFDSNYHYVRPTFSKTTQFKLNGQKPVDEFLEAKELGIHTRPVLLGPVSYLFLGKADKDSLDLEPLSLLEQLLPLYTEILSKLASAGATEVQIDEPVLVLDLPANAQAAIKKAYTYFGEQSNLPKITLATYFGTVVPNLDAIKGLPVAALHVDFVRAPEQFDEVVAAIGNKQTLSVGIVDGRNIWKNDFKKSSAIVNKAIEKLGADRVVVATSSSLLHTPVDLNNETKLDAEIKGFFSFATQKLDEVVVITKNVSGQDVAAALEANAKSVESRGKSKFIHDAAVKARVASIDEKMSTRAAPFEQRLPEQQKVFNLPLFPTTTIGSFPQTKDIRINRNKFNKGTISAEEYEKFINSEIEKVIRFQEEIGLDVLVHGEPERNDMVQYFGEQINGYAFTVNGWVQSYGSRYVRPPIIVGDLSRPKAMSVKESVYAQSITSKPVKGMLTGPITCLRWSFPRDDVDQKTQAMQLALALRDEVNDLEAAGIKVIQVDEPALREGLPLREGTERSAYYTWAAEAFRVATSGVANKTQIHSHFCYSDLDPNHIKALDADVVSIEFSKKDDANYIAEFKNYPNHIGLGLFDIHSPRIPSKDEFIAKISTILKSYPAEKFWVNPDCGLKTRGWEETRLSLTHMVEAAKYFREQYKN"},{"created_at":"2011-05-27T05:27:51.000Z","updated_at":"2011-05-27T15:01:24.000Z","name":"Methylenetetrahydrofolate reductase 1","uniprot_id":"P46151","uniprot_name":"MTHR1_YEAST","enzyme":true,"transporter":false,"gene_name":"MET12","num_residues":657,"molecular_weight":"73940.79688","theoretical_pi":"5.02","general_function":"Involved in methylenetetrahydrofolate reductase (NADPH) activity","specific_function":"5-methyltetrahydrofolate + NAD(P)(+) = 5,10- methylenetetrahydrofolate + NAD(P)H","reactions":[{"id":2773,"direction":"\u003e","locations":"","altext":"5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U36624","genbank_protein_id":"1039454","gene_card_id":"MET12","chromosome_location":"chromosome 16","locus":"YPL023C","synonyms":[],"enzyme_classes":["1.5.1.20"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" methylenetetrahydrofolate reductase (NADPH) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" sulfur amino acid metabolic process"},{"category":"Process","description":" methionine metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"MTHFR","identifier":"PF02219"}],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"gene_sequence":"ATGTCCATCAGAGATTTATATCATGCGAGGGCTTCCCCTTTTATATCGTTAGAATTCTTCCCTCCAAAGACTGAATTAGGGACGAGAAATTTGATGGAACGTATGCATCGTATGACTGCTTTAGATCCACTGTTTATCACGGTTACTTGGGGAGCAGGTGGTACTACTGCGGAAAAGACTCTGACATTAGCTTCCTTGGCACAGCAGACACTAAATATACCAGTTTGTATGCATTTGACCTGTACAAACACAGAAAAAGCCATCATTGATGATGCGCTGGATAGATGTTATAATGCAGGAATCAGGAATATTTTGGCTCTTCGAGGTGACCCACCTATTGGGGAAGATTGGCTAGATTCTCAATCGAACGAATCACCTTTTAAATATGCGGTTGATTTAGTTCGTTATATCAAGCAAAGCTACGGAGACAAGTTCTGCGTCGGTGTTGCAGCATATCCAGAAGGTCATTGTGAAGGTGAAGCAGAAGGTCACGAGCAAGACCCATTGAAGGATTTGGTATATTTAAAAGAAAAAGTTGAAGCTGGGGCCGATTTTGTGATAACACAACTGTTTTACGACGTTGAAAAATTCTTAACTTTTGAAATGCTATTTCGGGAACGGATTTCGCAAGATTTGCCCCTTTTCCCTGGGTTGATGCCTATTAACTCCTATCTGCTTTTCCACAGAGCAGCAAAGTTATCACATGCATCTATTCCACCTGCAATACTGAGTAGGTTCCCCCCAGAAATCCAATCGGATGATAATGCCGTGAAGTCCATTGGTGTGGACATTCTTATCGAATTGATTCAGGAAATATATCAAAGAACATCTGGTAGAATTAAAGGGTTTCATTTCTATACATTAAATTTGGAAAAGGCTATTGCTCAAATTGTCTCGCAATCTCCCGTCTTATCCCATATCGTAAATGAATCTAGCGAAGAAGAGGGAGAAGATGAAACCAGTGGCGAAATAGGAAGCATAGAAAATGTGCCAATAGAAGATGCTGACGGGGATATTGTGTTGGATGATTCGAATGAAGAAACTGTAGCAAACCGGAAAAGGAGAAGGCATTCAAGTCTTGATTCGGCCAAGTTGATTTTCAATAGGGCTATCGTCACTGAAAAAGGCTTACGCTATAATAATGAGAATGGTTCCATGCCATCTAAAAAGGCTTTAATATCTATTTCTAAAGGTCACGGAACTTTGGGTCGTGATGCCACTTGGGATGAGTTCCCCAATGGTAGATTTGGTGACTCCAGGTCTCCCGCATATGGTGAAATAGACGGTTATGGGCCATCCATCAAGGTAAGCAAAAGCAAAGCGCTTGAACTATGGGGTATACCAAAGACAATTGGCGATTTAAAAGATATTTTTATAAAATATTTGGAAGGTTCAACGGATGCGATTCCCTGGTCTGACCTGGGTTTATCAGCTGAAACGGCGTTAATACAAGAAGAACTAATCCAACTAAACTATCGCGGATATTTGACTTTGGCATCGCAACCTGCCACAAATGCTACATTGAGTAGTGATAAAATATTCGGCTGGGGGCCCGCGAAAGGGAGGTTGTATCAGAAGGCATTCGTAGAAATGTTTATTCATAGACAGCAATGGGAAACAACTTTGAAACCCAAGCTAGACCATTACGGGCGTCGGAAATTCAGTTATTACGCGGGCGATTCATCTGGTTCATTTGAAACGAACCTAGACCCGCACAGCTCTAGCGTTGTAACATGGGGTGTTTTTCCCAACAGTCCGGTCAAACAGACTACAATCATTGAAGAAGAGTCATTCAAGGCATGGAGAGATGAAGCGTTTAGTATCTGGTCCGAGTGGGCCAAGTTATTTCCAAGGAACACCCCAGCCAATATTCTTCTAAGACTAGTGCATAAAGACTACTGTCTTGTCTCAATTGTTCATCACGACTTCAAAGAAACCGACGAGCTATGGGAAATGTTACTCGACCAAGCCTAA","protein_sequence":"MSIRDLYHARASPFISLEFFPPKTELGTRNLMERMHRMTALDPLFITVTWGAGGTTAEKTLTLASLAQQTLNIPVCMHLTCTNTEKAIIDDALDRCYNAGIRNILALRGDPPIGEDWLDSQSNESPFKYAVDLVRYIKQSYGDKFCVGVAAYPEGHCEGEAEGHEQDPLKDLVYLKEKVEAGADFVITQLFYDVEKFLTFEMLFRERISQDLPLFPGLMPINSYLLFHRAAKLSHASIPPAILSRFPPEIQSDDNAVKSIGVDILIELIQEIYQRTSGRIKGFHFYTLNLEKAIAQIVSQSPVLSHIVNESSEEEGEDETSGEIGSIENVPIEDADGDIVLDDSNEETVANRKRRRHSSLDSAKLIFNRAIVTEKGLRYNNENGSMPSKKALISISKGHGTLGRDATWDEFPNGRFGDSRSPAYGEIDGYGPSIKVSKSKALELWGIPKTIGDLKDIFIKYLEGSTDAIPWSDLGLSAETALIQEELIQLNYRGYLTLASQPATNATLSSDKIFGWGPAKGRLYQKAFVEMFIHRQQWETTLKPKLDHYGRRKFSYYAGDSSGSFETNLDPHSSSVVTWGVFPNSPVKQTTIIEEESFKAWRDEAFSIWSEWAKLFPRNTPANILLRLVHKDYCLVSIVHHDFKETDELWEMLLDQA"},{"created_at":"2011-05-29T03:50:36.000Z","updated_at":"2011-07-22T17:53:50.000Z","name":"Methylenetetrahydrofolate reductase 2","uniprot_id":"P53128","uniprot_name":"MTHR2_YEAST","enzyme":true,"transporter":false,"gene_name":"MET13","num_residues":600,"molecular_weight":"68559.5","theoretical_pi":"5.58","general_function":"Involved in methylenetetrahydrofolate reductase (NADPH) activity","specific_function":"5-methyltetrahydrofolate + NAD(P)(+) = 5,10- methylenetetrahydrofolate + NAD(P)H","reactions":[{"id":1212,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2773,"direction":"\u003e","locations":"","altext":"5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"MET13","chromosome_location":"chromosome 7","locus":"YGL125W","synonyms":["YmL45"],"enzyme_classes":["1.5.1.20"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" methylenetetrahydrofolate reductase (NADPH) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" sulfur amino acid metabolic process"},{"category":"Process","description":" methionine metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"}],"pfams":[{"name":"MTHFR","identifier":"PF02219"}],"pathways":[{"name":"One carbon pool by folate","kegg_map_id":"00670"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"gene_sequence":"ATGAAGATCACAGAAAAATTAGAGCAACATAGACAGACCTCTGGCAAGCCCACTTACTCATTCGAGTACTTCGTCCCGAAGACTACACAAGGTGTACAGAACCTGTATGACCGGATGGACCGGATGTACGAGGCTTCTTTGCCCCAATTTATTGACATCACCTGGAATGCAGGCGGTGGACGGTTGTCACATCTGTCCACGGACTTGGTTGCGACAGCGCAGTCTGTGCTTGGTTTGGAAACGTGCATGCACCTTACCTGCACCAATATGCCCATTTCGATGATTGACGACGCTTTAGAAAACGCTTATCACTCCGGTTGCCAGAACATCCTAGCGCTGAGAGGAGATCCTCCTAGGGACGCAGAAAACTGGACTCCCGTTGAAGGTGGCTTCCAGTATGCCAAGGACTTGATTAAGTATATCAAGTCCAAGTACGGTGACCATTTCGCTATCGGCGTTGCCGGCTACCCGGAGTGCCATCCGGAGTTGCCTAACAAAGACGTGAAGCTTGATCTCGAGTATTTGAAGCAGAAGATCGACGCCGGCGGCGACTTCATCATCACTCAGATGTTTTACGATGTTGATAATTTCATCAACTGGTGTTCCCAAGTTAGAGCTGCGGGCATGGACGTGCCCATTATTCCCGGGATCATGCCGATCACTACCTACGCGGCCTTCTTGAGAAGGGCCCAATGGGGCCAAATCTCCATCCCTCAACATTTCTCGTCCCGATTGGATCCTATCAAGGACGATGACGAGTTGGTCCGTGATATCGGAACTAACTTGATCGTGGAAATGTGTCAAAAATTGCTCGACAGTGGTTACGTTTCTCACTTGCACATCTACACCATGAACTTGGAAAAAGCGCCTCTCATGATTCTGGAAAGATTGAACATTCTACCTACGGAATCAGAGTTCAATGCACATCCATTGGCCGTGTTGCCATGGAGAAAATCTTTGAATCCAAAGCGTAAAAACGAGGAAGTCAGACCTATCTTCTGGAAGAGAAGACCTTACTCCTATGTCGCAAGAACCTCTCAATGGGCCGTGGACGAATTCCCCAACGGTAGATTCGGTGATTCGTCTTCTCCTGCGTTCGGTGACTTGGATCTGTGTGGTTCAGACTTGATCAGGCAATCAGCGAACAAATGTCTCGAATTATGGTCCACCCCTACTTCCATCAACGACGTCGCCTTCTTGGTCATCAACTACTTGAATGGAAACTTGAAGTGTTTACCTTGGAGTGATATCCCCATCAATGATGAAATAAATCCAATCAAAGCACACTTGATTGAGCTGAACCAGCATTCTATCATCACTATAAACTCTCAACCTCAAGTCAACGGCATTAGGTCCAATGACAAAATTCATGGTTGGGGACCCAAGGATGGTTACGTTTACCAGAAGCAATATTTGGAATTTATGTTGCCCAAGACTAAGTTGCCCAAGTTGATTGACACCTTGAAAAACAATGAGTTCTTGACCTACTTCGCCATCGACTCTCAAGGTGACCTGCTAAGTAATCATCCAGACAACTCCAAGTCCAACGCTGTGACTTGGGGTATTTTCCCCGGCAGAGAAATTCTTCAACCTACCATTGTCGAGAAAATTTCGTTCTTAGCGTGGAAGGAGGAGTTCTATCATATCTTGAATGAATGGAAACTAAACATGAATAAATACGATAAACCGCATAGTGCCCAATTCATTCAGTCCTTGATTGACGATTACTGCTTGGTCAATATTGTTGACAATGACTACATTTCTCCAGATGATCAAATCCATTCCATCCTACTAAGCCTATAA","protein_sequence":"MKITEKLEQHRQTSGKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGGGRLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPRDAENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPELPNKDVKLDLEYLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQWGQISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLMILERLNILPTESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAVDEFPNGRFGDSSSPAFGDLDLCGSDLIRQSANKCLELWSTPTSINDVAFLVINYLNGNLKCLPWSDIPINDEINPIKAHLIELNQHSIITINSQPQVNGIRSNDKIHGWGPKDGYVYQKQYLEFMLPKTKLPKLIDTLKNNEFLTYFAIDSQGDLLSNHPDNSKSNAVTWGIFPGREILQPTIVEKISFLAWKEEFYHILNEWKLNMNKYDKPHSAQFIQSLIDDYCLVNIVDNDYISPDDQIHSILLSL"}]}