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Tryptophan metabolism

SourceIDPathway
PathWhizPW002442 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG00380 Map00380

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB00002L-Glutamine
56-85-9
(2S)-2-amino-4-carbamoylbutanoic acidC5H10N2O3
146.1445
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YMDB00007Quinolinic acid
89-00-9
pyridine-2,3-dicarboxylic acidC7H5NO4
167.1189
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YMDB000104-(2-Aminophenyl)-2,4-dioxobutanoic acid4-(2-aminophenyl)-2,4-dioxobutanoic acidC10H9NO4
207.1828
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YMDB00105L-3-Hydroxykynurenine
606-14-4
(2S)-2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acidC10H12N2O4
224.2133
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YMDB00110NAD
53-84-9
1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1λ⁵-pyridin-1-yliumC21H28N7O14P2
664.433
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YMDB00112L-Serine
56-45-1
(2S)-2-amino-3-hydroxypropanoic acidC3H7NO3
105.0926
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YMDB00115D-Glyceraldehyde 3-phosphate
142-10-9
(2-hydroxy-3-oxopropoxy)phosphonic acidC3H7O6P
170.0578
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YMDB00126L-Tryptophan
73-22-3
(2S)-2-amino-3-(1H-indol-3-yl)propanoic acidC11H12N2O2
204.2252
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YMDB00142Oxoadipic acid
3184-35-8
2-oxohexanedioic acidC6H8O5
160.1247
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YMDB00143NADH
58-68-4
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acidC21H29N7O14P2
665.441
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YMDB00148Chorismate
55508-12-8
(3R,4R)-3-[(1-carboxyeth-1-en-1-yl)oxy]-4-hydroxycyclohexa-1,5-diene-1-carboxylic acidC10H10O6
226.1828
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YMDB00153Oxoglutaric acid
328-50-7
2-oxopentanedioic acidC5H6O5
146.0981
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YMDB00154L-Alanine
56-41-7
(2S)-2-aminopropanoic acidC3H7NO2
89.0932
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YMDB001693-(indol-3-yl)pyruvic acid
392-12-1
3-(1H-indol-3-yl)-2-oxopropanoic acidC11H9NO3
203.1941
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YMDB00175Pyruvic acid
127-17-3
2-oxopropanoic acidC3H4O3
88.0621
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YMDB00179(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate[(2R,3S)-2,3-dihydroxy-3-(1H-indol-3-yl)propoxy]phosphonic acidC11H14NO6P
287.2057
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YMDB00219Pyrophosphate
14000-31-8
(phosphonooxy)phosphonic acidH4O7P2
177.9751
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YMDB00234N'-Formylkynurenine
1022-31-7
2-amino-4-(2-formamidophenyl)-4-oxobutanoic acidC11H12N2O4
236.224
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YMDB002511-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
5962-18-5
2-{[(3R,4R)-3,4-dihydroxy-2-oxo-5-(phosphonooxy)pentyl]amino}benzoic acidC12H16NO9P
349.2305
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YMDB002543-Hydroxyanthranilic acid
548-93-6
2-amino-3-hydroxybenzoic acidC7H7NO3
153.1354
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YMDB002652-Amino-3-carboxymuconic acid semialdehyde
16597-58-3
(2Z)-2-amino-3-[(1Z)-3-oxoprop-1-en-1-yl]but-2-enedioic acidC7H7NO5
185.1342
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YMDB00271L-Glutamic acid
56-86-0
(2S)-2-aminopentanedioic acidC5H9NO4
147.1293
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YMDB002782-Aminobenzoic acid
118-92-3
2-aminobenzoic acidC7H7NO2
137.136
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YMDB00304L-Phenylalanine
63-91-2
(2S)-2-amino-3-phenylpropanoic acidC9H11NO2
165.1891
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YMDB00312Acetyl-CoA
72-89-9
{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC23H38N7O17P3S
809.571
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YMDB00354Indoleacetaldehyde
2591-98-2
2-(1H-indol-3-yl)acetaldehydeC10H9NO
159.1846
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YMDB00375L-Kynurenine
343-65-7
(2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acidC10H12N2O3
208.2139
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YMDB00385Formic acid
64-18-6
formic acidCH2O2
46.0254
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YMDB00402Phosphoribosyl pyrophosphate
7540-64-9
[({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acidC5H13O14P3
390.0696
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YMDB00426NADPH
53-57-6
{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC21H30N7O17P3
745.4209
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YMDB00427NADP
53-59-8
1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1λ⁵-pyridin-1-yliumC21H29N7O17P3
744.4129
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YMDB004623-Hydroxyanthranilate
548-93-6
2-amino-3-hydroxybenzoic acidC7H7NO3
153.1354
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YMDB00529acetoacetyl-CoA
1420-36-6
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-{[2-({2-[(3-oxobutanoyl)sulfanyl]ethyl}carbamoyl)ethyl]carbamoyl}propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acidC25H40N7O18P3S
851.607
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YMDB00576indole-3-acetate
87-51-4
2-(1H-indol-3-yl)acetic acidC10H9NO2
175.184
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YMDB00577tryptophol
526-55-6
2-(1H-indol-3-yl)ethan-1-olC10H11NO
161.2004
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YMDB007091-C-(indol-3-yl)glycerol 3-phosphate[2,3-dihydroxy-3-(1H-indol-3-yl)propoxy]phosphonic acidC11H14NO6P
287.2057
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YMDB00725N-Formyl-L-kynurenine
1022-31-7
(2S)-2-amino-4-(2-formamidophenyl)-4-oxobutanoic acidC11H12N2O4
236.224
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YMDB00786keto-phenylpyruvic acid
156-06-9
2-oxo-3-phenylpropanoic acidC9H8O3
164.158
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YMDB00811N-Formylanthranilic acid
3342-77-6
2-formamidobenzoic acidC8H7NO3
165.1461
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YMDB00862hydron
12408-02-5
hydronH
1.00794
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YMDB00890water
7732-18-5
waterH2O
18.0153
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YMDB00900oxygen
7782-44-7
oxidanoneO2
31.9988
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YMDB00912Carbon dioxide
124-38-9
methanedioneCO2
44.0095
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YMDB00995D-Phenylalanine
673-06-3
(2R)-2-amino-3-phenylpropanoic acidC9H11NO2
165.1891
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YMDB01005N-(5-Phosphonato-beta-D-ribosyl)anthranilate2-{[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonatooxy)methyl]oxolan-2-yl]amino}benzoateC12H13NO9P
346.2067
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YMDB010693-(indol-3-yl)pyruvate
392-12-1
3-(1H-indol-3-yl)-2-oxopropanoateC11H8NO3
202.1861
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YMDB01092Anthranilate
118-92-3
2-aminobenzoateC7H6NO2
136.128
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YMDB16120Indole1H-indoleC8H7N
117.1479
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YMDB162771-C-(3-indolyl)-glycerol 3-phosphate(1S,2R)-1-(1H-indol-3-yl)-3-(phosphonatooxy)propane-1,2-diolC11H12NO6P
285.1898
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Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P00937TRP3
YKL211C
Anthranilate synthase component 2Enzyme
P00899TRP2
YER090W
Anthranilate synthase component 1Enzyme
P47039BNA3
YJL060W
Probable kynurenine--oxoglutarate transaminase BNA3Enzyme
P46367ALD4
YOR374W
Potassium-activated aldehyde dehydrogenase, mitochondrialEnzyme
P16467PDC5
YLR134W
Pyruvate decarboxylase isozyme 2Enzyme
P26263PDC6
YGR087C
Pyruvate decarboxylase isozyme 3Enzyme
P54115ALD6
YPL061W
Magnesium-activated aldehyde dehydrogenase, cytosolicEnzyme
P06169PDC1
YLR044C
Pyruvate decarboxylase isozyme 1Enzyme
P41338ERG10
YPL028W
Acetyl-CoA acetyltransferaseEnzyme
P07285TRP4
YDR354W
Anthranilate phosphoribosyltransferaseEnzyme
P22580AMD2
YDR242W
Probable amidaseEnzyme
P04803MSW1
YDR268W
Tryptophanyl-tRNA synthetase, mitochondrialEnzyme
Q12109WRS1
YOL097C
Tryptophanyl-tRNA synthetase, cytoplasmicEnzyme
P38169BNA4
YBL098W
Kynurenine 3-monooxygenaseEnzyme
Q05979BNA5
YLR231C
KynureninaseEnzyme
P22281ALD1
Aldehyde dehydrogenase 1, mitochondrialEnzyme
P00931TRP5
YGL026C
Tryptophan synthaseEnzyme
P25377ADH7
YCR105W
NADP-dependent alcohol dehydrogenase 7Enzyme
Q04894ADH6
YMR318C
NADP-dependent alcohol dehydrogenase 6Enzyme
P38840ARO9
YHR137W
Aromatic amino acid aminotransferase 2Enzyme
P53090ARO8
YGL202W
Aromatic amino acid aminotransferase 1Enzyme
P47125BNA2
YJR078W
Indoleamine 2,3-dioxygenase family proteinEnzyme
P20967KGD1
YIL125W
2-oxoglutarate dehydrogenase, mitochondrialEnzyme
P00912TRP1
YDR007W
N-(5'-phosphoribosyl)anthranilate isomeraseEnzyme
Q04066BNA7
YDR428C
Probable kynurenine formamidaseEnzyme
P47096BNA1
YJR025C
3-hydroxyanthranilate 3,4-dioxygenaseEnzyme
P06115CTT1
YGR088W
Catalase TEnzyme
P15202CTA1
YDR256C
Peroxisomal catalase AEnzyme