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Identification
YMDB IDYMDB00219
NamePyrophosphate
SpeciesSaccharomyces cerevisiae
StrainBaker's yeast
DescriptionPyrophosphate (PPi) is formed by the hydrolysis of nucleoside triphospates to nucleotides. It is unstable in aqueous solutions and rapidly hydrolyzes into inorganic phosphate (Pi).
Structure
Thumb
Synonyms
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
  • Pyrometaphosphate
  • Pyrophosphate
  • Pyrophosphate tetraanion
  • Pyrophosphate(4-) ion
  • Pyrophosphic acid
  • [(HO)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • Pyrophosphoric acid
  • Pyrophosphorsaeure
  • Na4p2O7
  • PPi CPD
CAS number14000-31-8
WeightAverage: 177.9751
Monoisotopic: 177.943225506
InChI KeyXPPKVPWEQAFLFU-UHFFFAOYSA-N
InChIInChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)
IUPAC Name(phosphonooxy)phosphonic acid
Traditional IUPAC Namepyrophosphoric acid
Chemical FormulaH4O7P2
SMILESOP(O)(=O)OP(O)(O)=O
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as non-metal pyrophosphates. These are inorganic non-metallic compounds containing a pyrophosphate as its largest oxoanion.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassNon-metal oxoanionic compounds
Sub ClassNon-metal pyrophosphates
Direct ParentNon-metal pyrophosphates
Alternative Parents
Substituents
  • Non-metal pyrophosphate
  • Inorganic oxide
Molecular FrameworkNot Available
External Descriptors
Physical Properties
StateSolid
Charge0
Melting point61 °C
Experimental Properties
PropertyValueReference
Water SolubilityNot AvailablePhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
logP-1.4ChemAxon
pKa (Strongest Acidic)1.7ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area124.29 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity25.52 m³·mol⁻¹ChemAxon
Polarizability10.28 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations
  • mitochondrion
  • lipid particle
  • endoplasmic reticulum
  • peroxisome
  • nucleus
  • cytoplasm
Organoleptic PropertiesNot Available
SMPDB Pathways
Amino sugar and nucleotide sugar metabolismPW002413 ThumbThumb?image type=greyscaleThumb?image type=simple
Asparagine metabolismPW002274 ThumbThumb?image type=greyscaleThumb?image type=simple
Biosynthesis of unsaturated fatty acidsPW002403 ThumbThumb?image type=greyscaleThumb?image type=simple
Biosynthesis of unsaturated fatty acids (docosanoyl)PW002408 ThumbThumb?image type=greyscaleThumb?image type=simple
Biosynthesis of unsaturated fatty acids (icosanoyl)PW002434 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Amino sugar and nucleotide sugar metabolismec00520 Map00520
Biosynthesis of unsaturated fatty acidsec01040 Map01040
Fatty acid metabolismec00071 Map00071
Glycerophospholipid metabolismec00564 Map00564
Lipoic acid metabolismec00785 Map00785
SMPDB Reactions
Acetyl-CoA + Adenosine triphosphate + Hydrogen carbonateADP + Pyrophosphate + malonyl-CoA
L-Aspartic acid + water + Adenosine triphosphate + L-GlutamineL-Asparagine + hydron + Adenosine monophosphate + L-Glutamic acid + Pyrophosphate
L-Aspartic acid + Adenosine triphosphate + AmmoniumL-Asparagine + Adenosine monophosphate + Pyrophosphate + hydron
Adenosine triphosphate + L-Aspartic acid + AmmoniaAdenosine monophosphate + L-Asparagine + Pyrophosphate
Adenosine triphosphate + L-Aspartic acid + L-Glutamine + waterAdenosine monophosphate + Pyrophosphate + L-Asparagine + L-Glutamic acid
KEGG Reactions
Adenosine triphosphate + Acetic acid + Coenzyme AAdenosine monophosphate + Pyrophosphate + Acetyl-CoA
Adenosine triphosphate + Acetic acid + Coenzyme AAdenosine monophosphate + Pyrophosphate + Acetyl-CoA
Phosphoribosyl pyrophosphate + AdenineAdenosine monophosphate + Pyrophosphate
Adenosine triphosphatePyrophosphate + 3',5'-cyclic AMP
Adenosine triphosphate + L-Alanine + tRNA(Ala) → Adenosine monophosphate + Pyrophosphate + Ala-tRNA(Ala)
Concentrations
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
GC-MSGC-MS Spectrum - GC-EI-TOF (Non-derivatized)splash10-0002-0972000000-a80f120dd426991d6effJSpectraViewer | MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Non-derivatized)splash10-0udi-0741900000-9c5b3c334561dd282116JSpectraViewer | MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Non-derivatized)splash10-03di-0920000000-a5ad76aa129d898d71f8JSpectraViewer | MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Non-derivatized)splash10-03di-0910000000-531d3e19493dc29d6e5cJSpectraViewer | MoNA
GC-MSGC-MS Spectrum - GC-MS (4 TMS)splash10-0udi-0320900000-0abbcb28a43d7e24fe81JSpectraViewer | MoNA
GC-MSGC-MS Spectrum - GC-MS (Non-derivatized)splash10-0udi-0320900000-0abbcb28a43d7e24fe81JSpectraViewer | MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-0002-9200000000-47d5c2340766aaf36e95JSpectraViewer
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-004j-5900000000-6633d5123eb37c266247JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0002-9000000000-1274b83242b279e9dac7JSpectraViewer | MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-001i-9000000000-69bc4c795fec87fef4b8JSpectraViewer | MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-004j-4900000000-fab623ebd43ab1452b9fJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0002-9400000000-b2565f0d436385569cffJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000t-9300000000-ac978f84efc222da7b43JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-004i-0900000000-21c64963e1ff18b360e1JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-9700000000-54e41043f009fe6db86cJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9000000000-2a5f69c16aa671275a62JSpectraViewer
References
References:
  • UniProt Consortium (2011). "Ongoing and future developments at the Universal Protein Resource." Nucleic Acids Res 39:D214-D219.21051339
  • Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). "BRENDA, the enzyme information system in 2011." Nucleic Acids Res 39:D670-D676.21062828
  • Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology." Nat Biotechnol 26:1155-1160.18846089
  • Shen, H., Heacock, P. N., Clancey, C. J., Dowhan, W. (1996). "The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth." J Biol Chem 271:789-795.8557688
  • Hoja, U., Wellein, C., Greiner, E., Schweizer, E. (1998). "Pleiotropic phenotype of acetyl-CoA-carboxylase-defective yeast cells--viability of a BPL1-amber mutation depending on its readthrough by normal tRNA(Gln)(CAG)." Eur J Biochem 254:520-526.9688262
  • Bhattacharjee, J. K. (1985). "alpha-Aminoadipate pathway for the biosynthesis of lysine in lower eukaryotes." Crit Rev Microbiol 12:131-151.3928261
  • He, B., Chen, P., Chen, S. Y., Vancura, K. L., Michaelis, S., Powers, S. (1991). "RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins." Proc Natl Acad Sci U S A 88:11373-11377.1763050
  • Magni, G., Amici, A., Emanuelli, M., Orsomando, G., Raffaelli, N., Ruggieri, S. (2004). "Structure and function of nicotinamide mononucleotide adenylyltransferase." Curr Med Chem 11:873-885.15078171
  • Ludmerer, S. W., Schimmel, P. (1985). "Cloning of GLN4: an essential gene that encodes glutaminyl-tRNA synthetase in Saccharomyces cerevisiae." J Bacteriol 163:763-768.2991203
  • Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., Cohen, H., Lin, S. S., Manchester, J. K., Gordon, J. I., Sinclair, D. A. (2002). "Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels." J Biol Chem 277:18881-18890.11884393
  • Lundin, M., Baltscheffsky, H., Ronne, H. (1991). "Yeast PPA2 gene encodes a mitochondrial inorganic pyrophosphatase that is essential for mitochondrial function." J Biol Chem 266:12168-12172.1648084
  • Turner, R. J., Lovato, M., Schimmel, P. (2000). "One of two genes encoding glycyl-tRNA synthetase in Saccharomyces cerevisiae provides mitochondrial and cytoplasmic functions." J Biol Chem 275:27681-27688.10874035
  • Masselot, M., Surdin-Kerjan, Y. (1977). "Methionine biosynthesis in Saccharomyces cerevisiae. II. Gene-enzyme relationships in the sulfate assimilation pathway." Mol Gen Genet 154:23-30.197388
  • Sato, M., Sato, K., Nishikawa, S., Hirata, A., Kato, J., Nakano, A. (1999). "The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis." Mol Cell Biol 19:471-483.9858571
  • Harris, C. L., Kolanko, C. J. (1995). "Aminoacyl-tRNA synthetase complex in Saccharomyces cerevisiae." Biochem J 309 ( Pt 1):321-324.7619074
  • Grabinska, K., Palamarczyk, G. (2002). "Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase." FEMS Yeast Res 2:259-265.12702274
  • Takahashi, H., McCaffery, J. M., Irizarry, R. A., Boeke, J. D. (2006). "Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription." Mol Cell 23:207-217.16857587
  • Chiang, P. K., Cantoni, G. L. (1977). "Activation of methionine for transmethylation. Purification of the S-adenosylmethionine synthetase of bakers' yeast and its separation into two forms." J Biol Chem 252:4506-4513.194884
  • Milewski, S., Gabriel, I., Olchowy, J. (2006). "Enzymes of UDP-GlcNAc biosynthesis in yeast." Yeast 23:1-14.16408321
  • van den Berg, M. A., de Jong-Gubbels, P., Kortland, C. J., van Dijken, J. P., Pronk, J. T., Steensma, H. Y. (1996). "The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation." J Biol Chem 271:28953-28959.8910545
  • Tzagoloff, A., Shtanko, A. (1995). "Mitochondrial and cytoplasmic isoleucyl-, glutamyl- and arginyl-tRNA synthetases of yeast are encoded by separate genes." Eur J Biochem 230:582-586.7607232
Synthesis Reference:Dittmer, Donald C.; Silverstein, V. Opshelor. Production of pyrophosphate from S-n-butyl phosphorothioate. Journal of Organic Chemistry (1961), 26 4706-7.
External Links:
ResourceLink
CHEBI ID29888
HMDB IDHMDB00250
Pubchem Compound ID1023
Kegg IDC00013
ChemSpider ID996
FOODB IDFDB030832
WikipediaPyrophosphate
BioCyc IDPPI

Enzymes

General function:
Involved in nucleotide binding
Specific function:
ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)
Gene Name:
GLN4
Uniprot ID:
P13188
Molecular weight:
93132.20313
Reactions
ATP + L-glutamine + tRNA(Gln) → AMP + diphosphate + L-glutaminyl-tRNA(Gln).
General function:
Involved in catalytic activity
Specific function:
ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate
Gene Name:
GUA1
Uniprot ID:
P38625
Molecular weight:
58481.80078
Reactions
ATP + xanthosine 5'-phosphate + L-glutamine + H(2)O → AMP + diphosphate + GMP + L-glutamate.
General function:
Involved in asparagine synthase (glutamine-hydrolyzing) activity
Specific function:
ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate
Gene Name:
ASN1
Uniprot ID:
P49089
Molecular weight:
64469.60156
Reactions
ATP + L-aspartate + L-glutamine + H(2)O → AMP + diphosphate + L-asparagine + L-glutamate.
General function:
Involved in asparagine synthase (glutamine-hydrolyzing) activity
Specific function:
ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate
Gene Name:
ASN2
Uniprot ID:
P49090
Molecular weight:
64592.5
Reactions
ATP + L-aspartate + L-glutamine + H(2)O → AMP + diphosphate + L-asparagine + L-glutamate.
General function:
Involved in amidophosphoribosyltransferase activity
Specific function:
5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O
Gene Name:
ADE4
Uniprot ID:
P04046
Molecular weight:
56718.89844
Reactions
5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate → L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O.
General function:
Involved in NAD+ synthase (glutamine-hydrolyzing) activity
Specific function:
ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate
Gene Name:
QNS1
Uniprot ID:
P38795
Molecular weight:
80684.89844
Reactions
ATP + deamido-NAD(+) + L-glutamine + H(2)O → AMP + diphosphate + NAD(+) + L-glutamate.
General function:
Involved in UDP-glucose:hexose-1-phosphate uridylyltransferase activity
Specific function:
UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose
Gene Name:
GAL7
Uniprot ID:
P08431
Molecular weight:
42384.69922
Reactions
UDP-glucose + alpha-D-galactose 1-phosphate → alpha-D-glucose 1-phosphate + UDP-galactose.
General function:
Involved in sulfate adenylyltransferase (ATP) activity
Specific function:
Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur- containing amino acids
Gene Name:
MET3
Uniprot ID:
P08536
Molecular weight:
57724.0
Reactions
ATP + sulfate → diphosphate + adenylyl sulfate.
General function:
Involved in nucleotide binding
Specific function:
Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs
Gene Name:
GRS1
Uniprot ID:
P38088
Molecular weight:
75410.20313
Reactions
ATP + glycine + tRNA(Gly) → AMP + diphosphate + glycyl-tRNA(Gly).
General function:
Involved in nucleotide binding
Specific function:
Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs
Gene Name:
GRS2
Uniprot ID:
Q06817
Molecular weight:
71017.89844
Reactions
ATP + glycine + tRNA(Gly) → AMP + diphosphate + glycyl-tRNA(Gly).
General function:
Involved in phosphorus-oxygen lyase activity
Specific function:
Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP
Gene Name:
CYR1
Uniprot ID:
P08678
Molecular weight:
227832.0
Reactions
ATP → 3',5'-cyclic AMP + diphosphate.
General function:
Involved in orotate phosphoribosyltransferase activity
Specific function:
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Gene Name:
URA5
Uniprot ID:
P13298
Molecular weight:
24664.19922
Reactions
Orotidine 5'-phosphate + diphosphate → orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in orotate phosphoribosyltransferase activity
Specific function:
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Gene Name:
URA10
Uniprot ID:
P30402
Molecular weight:
24810.30078
Reactions
Orotidine 5'-phosphate + diphosphate → orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in nucleotide binding
Specific function:
ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
Gene Name:
ISM1
Uniprot ID:
P48526
Molecular weight:
115793.0
Reactions
ATP + L-isoleucine + tRNA(Ile) → AMP + diphosphate + L-isoleucyl-tRNA(Ile).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)
Gene Name:
ILS1
Uniprot ID:
P09436
Molecular weight:
122982.0
Reactions
ATP + L-isoleucine + tRNA(Ile) → AMP + diphosphate + L-isoleucyl-tRNA(Ile).
General function:
Involved in UDP-N-acetylglucosamine diphosphorylase act
Specific function:
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-glucosamine
Gene Name:
QRI1
Uniprot ID:
P43123
Molecular weight:
53475.60156
Reactions
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate → diphosphate + UDP-N-acetyl-D-glucosamine.
General function:
Involved in catalytic activity
Specific function:
Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Contributes, with FAA1, to the activation of imported myristate
Gene Name:
FAA4
Uniprot ID:
P47912
Molecular weight:
77266.5
Reactions
ATP + a long-chain carboxylic acid + CoA → AMP + diphosphate + an acyl-CoA.
General function:
Involved in catalytic activity
Specific function:
Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It may supplement intracellular myristoyl-CoA pools from exogenous myristate. Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities
Gene Name:
FAA1
Uniprot ID:
P30624
Molecular weight:
77865.79688
Reactions
ATP + a long-chain carboxylic acid + CoA → AMP + diphosphate + an acyl-CoA.
General function:
Involved in catalytic activity
Specific function:
Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. This enzyme acts preferentially on C16 and C18 fatty acids with a cis-double bond at C-9-C-10
Gene Name:
FAA3
Uniprot ID:
P39002
Molecular weight:
77946.0
Reactions
ATP + a long-chain carboxylic acid + CoA → AMP + diphosphate + an acyl-CoA.
General function:
Involved in acetate-CoA ligase activity
Specific function:
Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Aerobic" isozyme of acetyl-coenzyme A synthetase, which supports growth on nonfermentable carbon sources such as glycerol and ethanol. May be required for assimilation of ethanol and acetate
Gene Name:
ACS1
Uniprot ID:
Q01574
Molecular weight:
79140.10156
Reactions
ATP + acetate + CoA → AMP + diphosphate + acetyl-CoA.
General function:
Involved in acetate-CoA ligase activity
Specific function:
Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. "Anaerobic" isozyme of acetyl-coenzyme A synthetase, which is required for growth on fermentable carbon sources such as glucose. May be involved in the PDH (pyruvate dehydrogenase complex) bypass
Gene Name:
ACS2
Uniprot ID:
P52910
Molecular weight:
75491.10156
Reactions
ATP + acetate + CoA → AMP + diphosphate + acetyl-CoA.
General function:
Involved in catalytic activity
Specific function:
Esterification, concomitant with transport, of endogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Preferentially acts on C9:0-C13:0 fatty acids although C7:0-C17:0 fatty acids are tolerated
Gene Name:
FAA2
Uniprot ID:
P39518
Molecular weight:
83437.10156
Reactions
ATP + a long-chain carboxylic acid + CoA → AMP + diphosphate + an acyl-CoA.
General function:
Coenzyme transport and metabolism
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P40506
Molecular weight:
41892.69922
Reactions
CTP + (R)-4'-phosphopantothenate + L-cysteine → CMP + PPi + N-((R)-4'-phosphopantothenoyl)-L-cysteine.
General function:
Involved in nucleotide binding
Specific function:
ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)
Gene Name:
Not Available
Uniprot ID:
P53852
Molecular weight:
87529.5
Reactions
ATP + L-cysteine + tRNA(Cys) → AMP + diphosphate + L-cysteinyl-tRNA(Cys).
General function:
Involved in hydrolase activity
Specific function:
Coenzyme A diphosphatase which mediates the cleavage of CoA into 3',5'-ADP and 4'-phosphopantetheine. Has a strong preference for oxidized CoA disulfide (CoASSCoA) as substrate. May be required to remove potentially toxic oxidized CoA disulfide to maintain the capacity for beta-oxidation of fatty acids. Can degrade 8-oxo-dGTP in vitro; however, such activity may not be relevant in vivo
Gene Name:
PCD1
Uniprot ID:
Q12524
Molecular weight:
39754.5
Reactions
8-oxo-dGTP + H(2)O → 8-oxo-dGMP + diphosphate.
General function:
Involved in argininosuccinate synthase activity
Specific function:
In yeast, as can have a catabolic function since it allows efficient utilization of citrulline via arginine and the reactions involved in the arginase pathway
Gene Name:
ARG1
Uniprot ID:
P22768
Molecular weight:
46939.30078
Reactions
ATP + L-citrulline + L-aspartate → AMP + diphosphate + N(omega)-(L-arginino)succinate.
General function:
Involved in anthranilate phosphoribosyltransferase activity
Specific function:
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1- diphosphate
Gene Name:
TRP4
Uniprot ID:
P07285
Molecular weight:
41374.0
Reactions
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate → anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in catalytic activity
Specific function:
Involved in the catabolism of quinolinic acid (QA)
Gene Name:
BNA6
Uniprot ID:
P43619
Molecular weight:
32364.69922
Reactions
Nicotinate D-ribonucleotide + diphosphate + CO(2) → pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme
Gene Name:
FAD1
Uniprot ID:
P38913
Molecular weight:
35545.80078
Reactions
ATP + FMN → diphosphate + FAD.
General function:
Involved in catalytic activity
Specific function:
CTP + choline phosphate = diphosphate + CDP- choline
Gene Name:
PCT1
Uniprot ID:
P13259
Molecular weight:
49405.80078
Reactions
CTP + choline phosphate → diphosphate + CDP-choline.
General function:
Involved in ATP binding
Specific function:
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Gene Name:
MOD5
Uniprot ID:
P07884
Molecular weight:
50236.19922
Reactions
Dimethylallyl diphosphate + tRNA → diphosphate + tRNA containing 6-dimethylallyladenosine.
General function:
Involved in isoprenoid biosynthetic process
Specific function:
Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate
Gene Name:
ERG20
Uniprot ID:
P08524
Molecular weight:
40483.0
Reactions
Dimethylallyl diphosphate + isopentenyl diphosphate → diphosphate + geranyl diphosphate.
Geranyl diphosphate + isopentenyl diphosphate → diphosphate + (2E,6E)-farnesyl diphosphate.
General function:
Involved in isoprenoid biosynthetic process
Specific function:
Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of YPT1 and SEC4. May be involved in vesicle trafficking and protein sorting
Gene Name:
BTS1
Uniprot ID:
Q12051
Molecular weight:
38651.0
Reactions
Dimethylallyl diphosphate + isopentenyl diphosphate → diphosphate + geranyl diphosphate.
Geranyl diphosphate + isopentenyl diphosphate → diphosphate + (2E,6E)-farnesyl diphosphate.
Trans,trans-farnesyl diphosphate + isopentenyl diphosphate → diphosphate + geranylgeranyl diphosphate.
General function:
Involved in nucleotide binding
Specific function:
ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
Gene Name:
AIM10
Uniprot ID:
P39965
Molecular weight:
65879.70313
Reactions
ATP + L-proline + tRNA(Pro) → AMP + diphosphate + L-prolyl-tRNA(Pro).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)
Gene Name:
MSR1
Uniprot ID:
P38714
Molecular weight:
73693.39844
Reactions
ATP + L-arginine + tRNA(Arg) → AMP + diphosphate + L-arginyl-tRNA(Arg).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)
Gene Name:
MSW1
Uniprot ID:
P04803
Molecular weight:
43015.10156
Reactions
ATP + L-tryptophan + tRNA(Trp) → AMP + diphosphate + L-tryptophyl-tRNA(Trp).
General function:
Involved in nucleotide binding
Specific function:
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis
Gene Name:
Not Available
Uniprot ID:
Q05506
Molecular weight:
69524.39844
Reactions
ATP + L-arginine + tRNA(Arg) → AMP + diphosphate + L-arginyl-tRNA(Arg).
General function:
Involved in nucleotide binding
Specific function:
Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins
Gene Name:
MSF1
Uniprot ID:
P08425
Molecular weight:
54828.39844
Reactions
ATP + L-phenylalanine + tRNA(Phe) → AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)
Gene Name:
VAS1
Uniprot ID:
P07806
Molecular weight:
125769.0
Reactions
ATP + L-valine + tRNA(Val) → AMP + diphosphate + L-valyl-tRNA(Val).
General function:
Involved in adenine phosphoribosyltransferase activity
Specific function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Gene Name:
APT1
Uniprot ID:
P49435
Molecular weight:
20586.59961
Reactions
AMP + diphosphate → adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in nucleotide binding
Specific function:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)
Gene Name:
MST1
Uniprot ID:
P07236
Molecular weight:
54091.60156
Reactions
ATP + L-threonine + tRNA(Thr) → AMP + diphosphate + L-threonyl-tRNA(Thr).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Gene Name:
CDC60
Uniprot ID:
P26637
Molecular weight:
124140.0
Reactions
ATP + L-leucine + tRNA(Leu) → AMP + diphosphate + L-leucyl-tRNA(Leu).
General function:
Involved in RNA binding
Specific function:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)
Gene Name:
FRS1
Uniprot ID:
P15624
Molecular weight:
67364.29688
Reactions
ATP + L-phenylalanine + tRNA(Phe) → AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
General function:
Involved in biotin-[acetyl-CoA-carboxylase] ligase activity
Specific function:
Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase
Gene Name:
BPL1
Uniprot ID:
P48445
Molecular weight:
76362.39844
Reactions
ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase] → AMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxytransferase].
ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] → AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)].
ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] → AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)].
ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] → AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)].
General function:
Involved in nucleotide binding
Specific function:
ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)
Gene Name:
FRS2
Uniprot ID:
P15625
Molecular weight:
57511.0
Reactions
ATP + L-phenylalanine + tRNA(Phe) → AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Gene Name:
NAM2
Uniprot ID:
P11325
Molecular weight:
101920.0
Reactions
ATP + L-leucine + tRNA(Leu) → AMP + diphosphate + L-leucyl-tRNA(Leu).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Gene Name:
MSM1
Uniprot ID:
P22438
Molecular weight:
66733.89844
Reactions
ATP + L-methionine + tRNA(Met) → AMP + diphosphate + L-methionyl-tRNA(Met).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)
Gene Name:
WRS1
Uniprot ID:
Q12109
Molecular weight:
49350.0
Reactions
ATP + L-tryptophan + tRNA(Trp) → AMP + diphosphate + L-tryptophyl-tRNA(Trp).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)
Gene Name:
HTS1
Uniprot ID:
P07263
Molecular weight:
59952.0
Reactions
ATP + L-histidine + tRNA(His) → AMP + diphosphate + L-histidyl-tRNA(His).
General function:
Involved in nucleotide binding
Specific function:
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Gene Name:
SES1
Uniprot ID:
P07284
Molecular weight:
53309.19922
Reactions
ATP + L-serine + tRNA(Ser) → AMP + diphosphate + L-seryl-tRNA(Ser).
ATP + L-serine + tRNA(Sec) → AMP + diphosphate + L-seryl-tRNA(Sec).
General function:
Involved in nucleotide binding
Specific function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Gene Name:
MSE1
Uniprot ID:
P48525
Molecular weight:
61602.69922
Reactions
ATP + L-glutamate + tRNA(Glu) → AMP + diphosphate + L-glutamyl-tRNA(Glu).
General function:
Involved in adenine phosphoribosyltransferase activity
Specific function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. May lack catalytic activity
Gene Name:
APT2
Uniprot ID:
P36973
Molecular weight:
19999.80078
Reactions
AMP + diphosphate → adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in nucleotide binding
Specific function:
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Gene Name:
MES1
Uniprot ID:
P00958
Molecular weight:
85677.39844
Reactions
ATP + L-methionine + tRNA(Met) → AMP + diphosphate + L-methionyl-tRNA(Met).
General function:
Involved in nucleotide binding
Specific function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction:alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain
Gene Name:
ALA1
Uniprot ID:
P40825
Molecular weight:
107276.0
Reactions
ATP + L-alanine + tRNA(Ala) → AMP + diphosphate + L-alanyl-tRNA(Ala).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)
Gene Name:
SLM5
Uniprot ID:
P25345
Molecular weight:
56784.39844
Reactions
ATP + L-asparagine + tRNA(Asn) → AMP + diphosphate + L-asparaginyl-tRNA(Asn).
General function:
Involved in nucleotide binding
Specific function:
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Gene Name:
DIA4
Uniprot ID:
P38705
Molecular weight:
50389.5
Reactions
ATP + L-serine + tRNA(Ser) → AMP + diphosphate + L-seryl-tRNA(Ser).
ATP + L-serine + tRNA(Sec) → AMP + diphosphate + L-seryl-tRNA(Sec).
General function:
Involved in nucleotide binding
Specific function:
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Gene Name:
MSY1
Uniprot ID:
P48527
Molecular weight:
55286.89844
Reactions
ATP + L-tyrosine + tRNA(Tyr) → AMP + diphosphate + L-tyrosyl-tRNA(Tyr).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)
Gene Name:
MSD1
Uniprot ID:
P15179
Molecular weight:
75460.0
Reactions
ATP + L-aspartate + tRNA(Asp) → AMP + diphosphate + L-aspartyl-tRNA(Asp).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)
Gene Name:
MSK1
Uniprot ID:
P32048
Molecular weight:
66127.60156
Reactions
ATP + L-lysine + tRNA(Lys) → AMP + diphosphate + L-lysyl-tRNA(Lys).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)
Gene Name:
KRS1
Uniprot ID:
P15180
Molecular weight:
67958.0
Reactions
ATP + L-lysine + tRNA(Lys) → AMP + diphosphate + L-lysyl-tRNA(Lys).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)
Gene Name:
DED81
Uniprot ID:
P38707
Molecular weight:
62206.30078
Reactions
ATP + L-asparagine + tRNA(Asn) → AMP + diphosphate + L-asparaginyl-tRNA(Asn).
General function:
Involved in nucleotide binding
Specific function:
ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
Gene Name:
Not Available
Uniprot ID:
P38708
Molecular weight:
77385.70313
Reactions
ATP + L-proline + tRNA(Pro) → AMP + diphosphate + L-prolyl-tRNA(Pro).
General function:
Involved in nucleotide binding
Specific function:
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). The specificity determinants on tRNA(Tyr) are the base pair C1-G72, the discriminator residue A73, and the three anticodon bases G34, U35 and A36. Also involved in nuclear tRNA export
Gene Name:
TYS1
Uniprot ID:
P36421
Molecular weight:
44019.60156
Reactions
ATP + L-tyrosine + tRNA(Tyr) → AMP + diphosphate + L-tyrosyl-tRNA(Tyr).
General function:
Involved in ligase activity
Specific function:
Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha- aminoadipate by NADPH
Gene Name:
LYS2
Uniprot ID:
P07702
Molecular weight:
155344.0
Reactions
L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O → L-2-aminoadipate + NAD(P)H.
General function:
Involved in nucleotide binding
Specific function:
ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)
Gene Name:
THS1
Uniprot ID:
P04801
Molecular weight:
84519.79688
Reactions
ATP + L-threonine + tRNA(Thr) → AMP + diphosphate + L-threonyl-tRNA(Thr).
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Gene Name:
SAM1
Uniprot ID:
P10659
Molecular weight:
41818.0
Reactions
ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine.
General function:
Involved in nucleotidyltransferase activity
Specific function:
ATP + nicotinamide ribonucleotide = diphosphate + NAD(+);ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+
Gene Name:
NMA2
Uniprot ID:
P53204
Molecular weight:
44908.69922
Reactions
ATP + nicotinamide ribonucleotide → diphosphate + NAD(+).
ATP + nicotinate ribonucleotide → diphosphate + deamido-NAD+
General function:
Involved in nucleotidyltransferase activity
Specific function:
ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)
Gene Name:
NMA1
Uniprot ID:
Q06178
Molecular weight:
45858.60156
Reactions
ATP + nicotinamide ribonucleotide → diphosphate + NAD(+).
General function:
Involved in RNA binding
Specific function:
This enzyme carries out synthesis of the tRNA CCA terminus without the direction of a template using the multiple accepting and donating subsites within its active site
Gene Name:
CCA1
Uniprot ID:
P21269
Molecular weight:
62484.39844
Reactions
A tRNA precursor + 2 CTP + ATP → a tRNA with a 3' CCA end + 3 diphosphate.
General function:
Involved in nucleotidyltransferase activity
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P53332
Molecular weight:
34306.30078
Reactions
ATP + pantetheine 4'-phosphate → diphosphate + 3'-dephospho-CoA.
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase
Gene Name:
FAS3
Uniprot ID:
Q00955
Molecular weight:
250351.0
Reactions
ATP + acetyl-CoA + HCO(3)(-) → ADP + phosphate + malonyl-CoA.
ATP + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].
General function:
Involved in ATP phosphoribosyltransferase activity
Specific function:
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity
Gene Name:
HIS1
Uniprot ID:
P00498
Molecular weight:
32266.09961
Reactions
1-(5-phospho-D-ribosyl)-ATP + diphosphate → ATP + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in catalytic activity
Specific function:
A phosphate monoester + H(2)O = an alcohol + phosphate
Gene Name:
PHO8
Uniprot ID:
P11491
Molecular weight:
63003.60156
Reactions
A phosphate monoester + H(2)O → an alcohol + phosphate.
(2E,6E)-farnesyl diphosphate + H(2)O → (2E,6E)-farnesol + diphosphate.
beta-D-fructose 2,6-bisphosphate + H2O → beta-D-fructofuranose 2-phosphate + phosphate
General function:
Involved in catalytic activity
Specific function:
Essential for thiamine biosynthesis. The kinase activity is involved in the salvage synthesis of TH-P from the thiazole
Gene Name:
THI6
Uniprot ID:
P41835
Molecular weight:
58058.19922
Reactions
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole → diphosphate + thiamine phosphate.
ATP + 4-methyl-5-(2-hydroxyethyl)thiazole → ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.
General function:
Involved in oxidoreductase activity
Specific function:
1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5- phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4-carboxamide
Gene Name:
HIS4
Uniprot ID:
P00815
Molecular weight:
87720.5
Reactions
1-(5-phosphoribosyl)-AMP + H(2)O → 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide.
1-(5-phosphoribosyl)-ATP + H(2)O → 1-(5-phosphoribosyl)-AMP + diphosphate.
L-histidinol + H(2)O + 2 NAD(+) → L-histidine + 2 NADH.
General function:
Involved in catalytic activity
Specific function:
CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine
Gene Name:
MUQ1
Uniprot ID:
P33412
Molecular weight:
36862.60156
Reactions
CTP + ethanolamine phosphate → diphosphate + CDP-ethanolamine.
General function:
Involved in GTP cyclohydrolase II activity
Specific function:
Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate
Gene Name:
RIB1
Uniprot ID:
P38066
Molecular weight:
38331.60156
Reactions
GTP + 3 H(2)O → formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.
General function:
Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups
Specific function:
Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP)
Gene Name:
NUS1
Uniprot ID:
Q12063
Molecular weight:
42556.69922
Reactions
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate → 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.
General function:
Involved in nicotinate phosphoribosyltransferase activity
Specific function:
Essential for growth under anaerobic conditions
Gene Name:
NPT1
Uniprot ID:
P39683
Molecular weight:
49018.19922
Reactions
Nicotinate D-ribonucleotide + diphosphate → nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in isoprenoid biosynthetic process
Specific function:
Assembly of polyisoprenoid side chains. The polyprenyl synthase of coenzyme Q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species
Gene Name:
COQ1
Uniprot ID:
P18900
Molecular weight:
52558.89844
Reactions
General function:
Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups
Specific function:
Could be a cis-prenyl transferase that adds multiple copies of isopentenyl pyrophosphate (ipp) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (DeDol- PP)
Gene Name:
SRT1
Uniprot ID:
Q03175
Molecular weight:
40199.69922
Reactions
General function:
Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups
Specific function:
Cis-prenyl transferase that adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP)
Gene Name:
RER2
Uniprot ID:
P35196
Molecular weight:
32693.30078
Reactions
General function:
Involved in hydrolase activity
Specific function:
This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
Gene Name:
DUT1
Uniprot ID:
P33317
Molecular weight:
15307.2002
Reactions
dUTP + H(2)O → dUMP + diphosphate.
General function:
Involved in transferase activity
Specific function:
Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell- size checkpoint
Gene Name:
MPG1
Uniprot ID:
P41940
Molecular weight:
39565.60156
Reactions
GTP + alpha-D-mannose 1-phosphate → diphosphate + GDP-mannose.
General function:
Involved in nucleotidyltransferase activity
Specific function:
Plays a central role as a glucosyl donor in cellular metabolic pathways
Gene Name:
Not Available
Uniprot ID:
P38709
Molecular weight:
55999.80078
Reactions
UTP + alpha-D-glucose 1-phosphate → diphosphate + UDP-glucose.
General function:
Involved in nucleotidyltransferase activity
Specific function:
Plays a central role as a glucosyl donor in cellular metabolic pathways
Gene Name:
UGP1
Uniprot ID:
P32861
Molecular weight:
55987.39844
Reactions
UTP + alpha-D-glucose 1-phosphate → diphosphate + UDP-glucose.
General function:
Involved in magnesium ion binding
Specific function:
Involved in energy production. Its activity is stimulated by uncouplers of ATP synthesis
Gene Name:
PPA2
Uniprot ID:
P28239
Molecular weight:
35572.39844
Reactions
Diphosphate + H(2)O → 2 phosphate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal sequence Cys-Ile-Ile-Leu or Cys-Val-Leu-Leu. Acts, among other substrates, on Rho1 and Rho2 and CDC42 proteins. Participates in a RAS-like C-terminal modification of proteins involved in nuclear division and bud growth. It is involved in bud positioning and cell polarity
Gene Name:
CDC43
Uniprot ID:
P18898
Molecular weight:
42689.10156
Reactions
Geranylgeranyl diphosphate + protein-cysteine → S-geranylgeranyl-protein + diphosphate.
General function:
Involved in DNA binding
Specific function:
Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome
Gene Name:
TY2B-OR1
Uniprot ID:
Q12113
Molecular weight:
201982.0
Reactions
Deoxynucleoside triphosphate + DNA(n) → diphosphate + DNA(n+1).
General function:
Involved in protein prenyltransferase activity
Specific function:
Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate
Gene Name:
RAM2
Uniprot ID:
P29703
Molecular weight:
37507.30078
Reactions
Farnesyl diphosphate + protein-cysteine → S-farnesyl protein + diphosphate.
Geranylgeranyl diphosphate + protein-cysteine → S-geranylgeranyl-protein + diphosphate.
General function:
Involved in transferase activity
Specific function:
May regulate the flux of isoprene intermediates through the sterol pathway. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. ERG9 is also essential for cell growth in yeast
Gene Name:
ERG9
Uniprot ID:
P29704
Molecular weight:
51719.39844
Reactions
2 farnesyl diphosphate → diphosphate + presqualene diphosphate.
Presqualene diphosphate + NAD(P)H → squalene + diphosphate + NAD(P)(+).
General function:
Involved in magnesium ion binding
Specific function:
Diphosphate + H(2)O = 2 phosphate
Gene Name:
IPP1
Uniprot ID:
P00817
Molecular weight:
32299.30078
Reactions
Diphosphate + H(2)O → 2 phosphate.
General function:
Involved in prenyltransferase activity
Specific function:
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB
Gene Name:
COQ2
Uniprot ID:
P32378
Molecular weight:
41001.0
Reactions
A polyprenyl diphosphate + 4-hydroxybenzoate → diphosphate + a 4-hydroxy-3-polyprenylbenzoate.
General function:
Involved in nucleoside metabolic process
Specific function:
IMP + diphosphate = hypoxanthine + 5-phospho- alpha-D-ribose 1-diphosphate
Gene Name:
HPT1
Uniprot ID:
Q04178
Molecular weight:
25190.5
Reactions
IMP + diphosphate → hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
GMP + diphosphate → guanine + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4
Gene Name:
BET2
Uniprot ID:
P20133
Molecular weight:
36665.60156
Reactions
Geranylgeranyl diphosphate + protein-cysteine → S-geranylgeranyl-protein + diphosphate.
General function:
Involved in transferase activity, transferring phosphorus-containing groups
Specific function:
Supplies CDP-diacylglycerol, which may play an important role as both a precursor to phosphoinositide biosynthesis in the plasma membrane and as a negative effector of phosphatidylinositol 4-kinase activity, thereby exerting an effect on cell proliferation via a lipid-dependent signal transduction cascade
Gene Name:
CDS1
Uniprot ID:
P38221
Molecular weight:
51822.39844
Reactions
CTP + phosphatidate → diphosphate + CDP-diacylglycerol.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins such as a-factor and RAS. The beta subunit is responsible for peptide-binding
Gene Name:
RAM1
Uniprot ID:
P22007
Molecular weight:
48189.39844
Reactions
Farnesyl diphosphate + protein-cysteine → S-farnesyl protein + diphosphate.
General function:
Involved in protoheme IX farnesyltransferase activity
Specific function:
Converts protoheme IX and farnesyl diphosphate to heme O
Gene Name:
COX10
Uniprot ID:
P21592
Molecular weight:
52147.19922
Reactions
General function:
Involved in nucleoside metabolic process
Specific function:
May act as a xanthine phosphoribosyltransferase involved in the synthesis of purine nucleotides. Such activity is however unclear in vivo
Gene Name:
XPT1
Uniprot ID:
P47165
Molecular weight:
23671.0
Reactions
General function:
Nucleotide transport and metabolism
Specific function:
Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Gene Name:
FUR1
Uniprot ID:
P18562
Molecular weight:
24594.19922
Reactions
UMP + diphosphate → uracil + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Coenzyme transport and metabolism
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Gene Name:
SAM2
Uniprot ID:
P19358
Molecular weight:
42255.5
Reactions
ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine.
General function:
Involved in protein prenyltransferase activity
Specific function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4
Gene Name:
BET4
Uniprot ID:
Q00618
Molecular weight:
39674.30078
Reactions
Geranylgeranyl diphosphate + protein-cysteine → S-geranylgeranyl-protein + diphosphate.
General function:
Involved in pantoate-beta-alanine ligase activity
Specific function:
Required for pantothenic acid biosynthesis
Gene Name:
PAN6
Uniprot ID:
P40459
Molecular weight:
35031.89844
Reactions
ATP + (R)-pantoate + beta-alanine → AMP + diphosphate + (R)-pantothenate.
General function:
Involved in dihydropteroate synthase activity
Specific function:
Catalyzes three sequential steps of tetrahydrofolate biosynthesis
Gene Name:
FOL1
Uniprot ID:
P53848
Molecular weight:
93119.10156
Reactions
2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine → 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.
ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine → AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate → diphosphate + dihydropteroate.
General function:
Involved in nucleotide binding
Specific function:
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Gene Name:
GUS1
Uniprot ID:
P46655
Molecular weight:
80842.0
Reactions
ATP + L-glutamate + tRNA(Glu) → AMP + diphosphate + L-glutamyl-tRNA(Glu).
General function:
Involved in catalytic activity
Specific function:
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes
Gene Name:
AIM22
Uniprot ID:
P47051
Molecular weight:
47003.0
Reactions
ATP + lipoate → diphosphate + lipoyl-AMP.
Lipoyl-AMP + protein → protein N(6)-(lipoyl)lysine + AMP.
General function:
CDP-diacylglycerol biosynthetic process
Specific function:
Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.
Gene Name:
TAM41
Uniprot ID:
P53230
Molecular weight:
44199.33
Reactions

Transporters

General function:
Involved in catalytic activity
Specific function:
May be involved in long-chain fatty acids uptake, and thus may play a pivotal role in regulating their accessibility prior to metabolic utilization. May play an important role in uptake of these hydrophobic compounds under conditions where fatty acid synthesis is compromised
Gene Name:
FAT1
Uniprot ID:
P38225
Molecular weight:
77140.29688
Reactions
General function:
Involved in DNA binding
Specific function:
Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome
Gene Name:
TY1B-OL
Uniprot ID:
Q12273
Molecular weight:
198613.0
Reactions
Deoxynucleoside triphosphate + DNA(n) → diphosphate + DNA(n+1).