{"ymdb_id":"YMDB00278","created_at":"2011-05-29T18:01:25.000Z","updated_at":"2016-09-08T18:35:17.000Z","name":"2-Aminobenzoic acid","cas":"118-92-3","state":"Solid","melting_point":"146.5 oC","description":"Anthranilic acid (2-aminobenzoic acid) is an amino acid with a sweetish taste precursor to the amino acid tryptophan. Anthranilic acid is biosynthesized from chorismic acid, an important biochemical intermediate in plants and microorganisms. [Biocyc TRPSYN-PWY]","experimental_water_solubility":"3.5 mg/mL at 20 oC [YALKOWSKY,SH \u0026 DANNENFELSER,RM (1992)]","experimental_logp_hydrophobicity":"1.21 [HANSCH,C ET AL. (1995)]","location":"cytoplasm","synthesis_reference":"Wang, Chengyin; Yang, Jisheng; Wang, Honghai.  Production of o-aminobenzoic acid from by-product o-nitrobenzoic acid.    Huaxue Shijie  (1999),  40(5),  274-277. ","chebi_id":"30754","hmdb_id":"HMDB01123","kegg_id":"C00108","pubchem_id":"227","cs_id":"222","foodb_id":null,"wikipedia_link":"Anthranilic_acid","biocyc_id":"ANTHRANILATE","iupac":"2-aminobenzoic acid","traditional_iupac":"2-aminobenzoic acid","logp":"1.4519027699999998","pka":"19.44069433947566","alogps_solubility":"6.81e+00 g/l","alogps_logp":"0.78","alogps_logs":"-1.30","acceptor_count":"3","donor_count":"2","rotatable_bond_count":"1","polar_surface_area":"63.32","refractivity":"38.0146","polarizability":"13.288743336988986","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"1.9474348350285466","pka_strongest_acidic":"4.892673611619119","bioavailability":"1","number_of_rings":"1","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["1-Amino-2-carboxybenzene","2-amino-Benzoate","2-amino-Benzoic acid","2-Aminobenzoate","2-Aminobenzoic acid","2-Aminophenylacetate","2-Aminophenylacetic acid","2-Carboxyaniline","Aminobenzoic acid","Anthranate","Anthranic acid","Anthranilate","Anthranilic acid","anthranilic acid gr","Benzoic acid, 2-amino-","Benzoic acid, o-amino-","Carboxyaniline","Kyselina anthranilova","Kyselina o-aminobenzoova","o-amino-Benzoate","o-amino-Benzoic acid","o-Aminobenzoate","o-Aminobenzoic acid","o-Anthranilate","o-Anthranilic acid","o-Carboxyaniline","Ortho-amidobenzoate","Ortho-amidobenzoic acid","Ortho-aminobenzoate","Ortho-aminobenzoic acid","Vitamin L","Vitamin L1"],"pathways":[{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":8001582,"citation":"Crombie, T., Boyle, J. P., Coggins, J. R., Brown, A. J. (1994). \"The folding of the bifunctional TRP3 protein in yeast is influenced by a translational pause which lies in a region of structural divergence with Escherichia coli indoleglycerol-phosphate synthase.\" Eur J Biochem 226:657-664."},{"pubmed_id":12062417,"citation":"Panozzo, C., Nawara, M., Suski, C., Kucharczyka, R., Skoneczny, M., Becam, A. M., Rytka, J., Herbert, C. J. (2002). \"Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae.\" FEBS Lett 517:97-102."}],"proteins":[{"created_at":"2011-05-24T19:23:19.000Z","updated_at":"2011-05-27T14:55:57.000Z","name":"Anthranilate synthase component 2","uniprot_id":"P00937","uniprot_name":"TRPG_YEAST","enzyme":true,"transporter":false,"gene_name":"TRP3","num_residues":484,"molecular_weight":"53488.89844","theoretical_pi":"6.91","general_function":"Involved in catalytic activity","specific_function":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate","reactions":[{"id":1657,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2251,"direction":"\u003e","locations":"","altext":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":2252,"direction":"\u003e","locations":null,"altext":"1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":14103,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006527","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"K01386","genbank_protein_id":"173045","gene_card_id":"TRP3","chromosome_location":"chromosome 11","locus":"YKL211C","synonyms":["Anthranilate synthase component II","Glutamine amidotransferase","Indole-3-glycerol phosphate synthase","PRAI"],"enzyme_classes":["4.1.3.27","4.1.1.48"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" anthranilate synthase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" indole-3-glycerol-phosphate synthase activity"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" indolalkylamine metabolic process"},{"category":"Process","description":" tryptophan metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glutamine family amino acid metabolic process"},{"category":"Process","description":" glutamine metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"GATase","identifier":"PF00117"},{"name":"IGPS","identifier":"PF00218"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGTCTGTGCACGCTGCAACAAACCCAATCAATAAGCATGTGGTTCTAATTGACAACTACGATTCCTTTACCTGGAACGTTTACGAGTACTTGTGCCAGGAGGGCGCCAAAGTGAGCGTCTACCGTAACGATGCAATTACAGTTCCAGAAATTGCCGCCTTGAATCCCGACACATTGCTTATCTCGCCTGGACCAGGCCACCCAAAGACAGATTCTGGCATTTCAAGAGACTGTATCCGGTACTTTACTGGGAAAATTCCTGTATTTGGAATCTGTATGGGCCAGCAATGCATGTTTGACGTATTTGGTGGTGAAGTTGCCTACGCTGGTGAGATTGTCCACGGTAAAACGTCCCCAATCTCTCACGACAACTGTGGAATTTTCAGGAACGTGCCGCAAGGTATTGCTGTGACAAGATACCATTCATTGGCCGGGACAGAATCGTCCCTACCATCCTGCTTGAAGGTTACTGCGAGTACCGAAAATGGAATTATCATGGGTGTAAGACACAAGAAGTACACTGTAGAAGGTGTGCAATTTCATCCGGAATCCATCTTGACCGAGGAAGGTCATCTGATGATCAGGAACATTTTAAACGTCAGTGGAGGCACTTGGGAGGAAAACAAATCATCTCCTTCAAATTCTATTTTGGACCGTATCTATGCTCGGCGTAAAATAGACGTCAATGAGCAGTCTAAAATCCCAGGTTTCACCTTTCAAGACTTACAATCTAACTATGATTTAGGTCTTGCCCCACCGTTACAGGATTTCTACACGGTGTTGTCATCATCCCATAAAAGAGCCGTTGTTCTTGCTGAAGTCAAGCGTGCCTCTCCATCGAAGGGACCCATTTGTTTAAAAGCTGTTGCTGCTGAACAGGCTCTCAAATACGCAGAGGCTGGTGCATCCGCAATTTCCGTATTGACCGAACCTCATTGGTTTCACGGTTCGTTACAGGATTTAGTAAATGTGAGGAAAATCCTAGATTTGAAATTTCCTCCCAAGGAGAGGCCTTGTGTTTTGAGAAAAGAATTTATTTTCAGCAAGTATCAAATACTAGAAGCAAGATTAGCTGGAGCTGACACTGTCCTTCTTATAGTCAAGATGCTATCTCAACCCTTATTGAAGGAACTGTACAGCTACAGTAAAGATTTGAACATGGAACCTCTCGTTGAGGTGAACTCCAAAGAGGAATTACAAAGGGCTCTAGAAATTGGTGCTAAAGTTGTAGGTGTCAATAATAGGGACCTGCATTCATTCAACGTAGACCTAAATACCACCAGTAACTTGGTAGAATCTATTCCAAAGGATGTTCTTCTAATTGCTCTATCGGGAATTACCACCAGGGACGATGCTGAAAAATACAAAAAAGAAGGTGTCCATGGATTTTTAGTGGGTGAAGCCCTAATGAAATCAACCGATGTGAAGAAGTTCATTCATGAATTATGCGAATAA","protein_sequence":"MSVHAATNPINKHVVLIDNYDSFTWNVYEYLCQEGAKVSVYRNDAITVPEIAALNPDTLLISPGPGHPKTDSGISRDCIRYFTGKIPVFGICMGQQCMFDVFGGEVAYAGEIVHGKTSPISHDNCGIFKNVPQGIAVTRYHSLAGTESSLPSCLKVTASTENGIIMGVRHKKYTVEGVQFHPESILTEEGHLMIRNILNVSGGTWEENKSSPSNSILDRIYARRKIDVNEQSKIPGFTFQDLQSNYDLGLAPPLQDFYTVLSSSHKRAVVLAEVKRASPSKGPICLKAVAAEQALKYAEAGASAISVLTEPHWFHGSLQDLVNVRKILDLKFPPKERPCVLRKEFIFSKYQILEARLAGADTVLLIVKMLSQPLLKELYSYSKDLNMEPLVEVNSKEELQRALEIGAKVVGVNNRDLHSFNVDLNTTSNLVESIPKDVLLIALSGITTRDDAEKYKKEGVHGFLVGEALMKSTDVKKFIHELCE"},{"created_at":"2011-05-24T19:34:32.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Anthranilate synthase component 1","uniprot_id":"P00899","uniprot_name":"TRPE_YEAST","enzyme":true,"transporter":false,"gene_name":"TRP2","num_residues":507,"molecular_weight":"56767.0","theoretical_pi":"5.65","general_function":"Involved in biosynthetic process","specific_function":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate","reactions":[{"id":2251,"direction":"\u003e","locations":"","altext":"Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.","export":false,"pw_reaction_id":null,"source":null},{"id":14103,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006527","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U18839","genbank_protein_id":"603328","gene_card_id":"TRP2","chromosome_location":"chromosome 5","locus":"YER090W","synonyms":["Anthranilate synthase component I"],"enzyme_classes":["4.1.3.27"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" anthranilate synthase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Process","description":" indolalkylamine metabolic process"},{"category":"Process","description":" tryptophan metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" tryptophan biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"}],"pfams":[{"name":"Anth_synt_I_N","identifier":"PF04715"},{"name":"Chorismate_bind","identifier":"PF00425"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGACCGCTTCCATCAAAATTCAACCGGATATTGACTCTCTAAAGCAATTACAGCAGCAAAATGACGATAGTTCCATAAATATGTATCCCGTGTATGCGTATTTGCCATCATTGGATCTGACTCCTCACGTGGCATATCTAAAATTGGCACAATTGAACAACCCTGATAGAAAGGAATCATTTCTGTTGGAAAGTGCTAAGACAAATAATGAATTAGATCGTTATTCATTCATAGGTATCTCGCCACGCAAGACCATCAAAACCGGTCCTACTGAAGGCATTGAAACAGATCCTTTGGAAATTTTGGAAAAGGAGATGTCTACCTTTAAAGTAGCCGAAAATGTTCCTGGTTTACCGAAATTAAGTGGTGGTGCTATTGGTTATATTTCTTATGACTGTGTTCGTTATTTCGAGCCAAAAACAAGAAGGCCTTTGAAAGATGTCCTAAGACTTCCAGAGGCATATTTAATGCTTTGTGATACCATTATTGCCTTTGATAATGTTTTTCAGAGATTTCAAATCATTCATAACATTAATACCAATGAAACTTCGTTGGAGGAAGGTTACCAAGCTGCAGCACAAATAATCACTGATATCGTATCAAAGCTAACCGACGATTCCTCGCCAATACCATATCCAGAACAACCTCCTATTAAATTGAATCAAACTTTTGAATCGAATGTGGGCAAGGAAGGTTACGAAAATCACGTCTCCACTTTGAAGAAGCATATTAAGAAAGGTGATATTATTCAAGGTGTGCCATCGCAAAGAGTGGCAAGGCCAACTTCGTTACATCCTTTCAATATTTACAGACATTTACGTACAGTGAACCCATCTCCTTACCTGTTTTATATTGATTGTTTGGATTTCCAAATCATTGGTGCATCTCCAGAATTGTTGTGCAAATCGGATTCCAAAAATAGAGTCATTACCCATCCAATTGCTGGTACTGTCAAACGTGGGGCTACTACTGAAGAGGATGATGCTTTAGCGGACCAATTACGTGGCTCGTTAAAAGACCGTGCAGAACATGTTATGCTGGTAGATTTAGCAAGAAACGATATTAACAGAATTTGTGACCCATTAACAACAAGTGTCGATAAACTGTTAACTATTCAAAAATTTTCTCATGTCCAACATCTGGTTTCTCAAGTCAGCGGTGTTCTCCGCCCAGAAAAGACAAGATTTGATGCATTCAGATCGATTTTCCCTGCAGGTACTGTCAGTGGTGCTCCAAAGGTTAGAGCCATGGAATTGATTGCCGAACTAGAAGGAGAAAGGCGTGGGGTTTATGCAGGCGCCGTAGGTCATTGGTCATACGACGGTAAAACAATGGACAATTGTATCGCTTTAAGGACTATGGTCTATAAAGATGGCATTGCTTACTTGCAAGCTGGCGGTGGTATTGTTTACGATTCAGATGAGTACGATGAATATGTCGAAACCATGAATAAAATGATGGCCAATCACAGTACTATTGTGCAAGCAGAAGAATTGTGGGCCGATATCGTAGGATCAGCTTAA","protein_sequence":"MTASIKIQPDIDSLKQLQQQNDDSSINMYPVYAYLPSLDLTPHVAYLKLAQLNNPDRKESFLLESAKTNNELDRYSFIGISPRKTIKTGPTEGIETDPLEILEKEMSTFKVAENVPGLPKLSGGAIGYISYDCVRYFEPKTRRPLKDVLRLPEAYLMLCDTIIAFDNVFQRFQIIHNINTNETSLEEGYQAAAQIITDIVSKLTDDSSPIPYPEQPPIKLNQTFESNVGKEGYENHVSTLKKHIKKGDIIQGVPSQRVARPTSLHPFNIYRHLRTVNPSPYLFYIDCLDFQIIGASPELLCKSDSKNRVITHPIAGTVKRGATTEEDDALADQLRGSLKDRAEHVMLVDLARNDINRICDPLTTSVDKLLTIQKFSHVQHLVSQVSGVLRPEKTRFDAFRSIFPAGTVSGAPKVRAMELIAELEGERRGVYAGAVGHWSYDGKTMDNCIALRTMVYKDGIAYLQAGGGIVYDSDEYDEYVETMNKMMANHSTIVQAEELWADIVGSA"},{"created_at":"2011-05-26T16:44:50.000Z","updated_at":"2011-07-22T17:54:11.000Z","name":"Anthranilate phosphoribosyltransferase","uniprot_id":"P07285","uniprot_name":"TRPD_YEAST","enzyme":true,"transporter":false,"gene_name":"TRP4","num_residues":380,"molecular_weight":"41374.0","theoretical_pi":"6.66","general_function":"Involved in anthranilate phosphoribosyltransferase activity","specific_function":"N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1- diphosphate","reactions":[{"id":1322,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2442,"direction":"\u003e","locations":null,"altext":"N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14104,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006528","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U28372","genbank_protein_id":"849174","gene_card_id":"TRP4","chromosome_location":"chromosome 4","locus":"YDR354W","synonyms":[],"enzyme_classes":["2.4.2.18"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring pentosyl groups"},{"category":"Function","description":" anthranilate phosphoribosyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" tryptophan biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" indolalkylamine metabolic process"},{"category":"Process","description":" tryptophan metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"Glycos_trans_3N","identifier":"PF02885"},{"name":"Glycos_transf_3","identifier":"PF00591"}],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Tryptophan metabolism","kegg_map_id":"00380"}],"gene_sequence":"ATGTCCGAGGCGACTTTGCTATCTTACACCAAGAAATTATTGGCTTCTCCGCCGCAATTGAGTAGCACAGACCTACACGATGCGTTGCTGGTTATATTAAGTCTTTTGCAAAAATGTGATACAAATAGCGATGAGAGTCTTTCCATCTATACCAAAGTTTCGAGTTTTCTCACGGCCTTGAGAGTTACTAAACTTGATCACAAGGCTGAATACATTGCGGAAGCTGCAAAGGCTGTGCTCAGACATTCCGACCTTGTTGATCTACCTTTACCCAAGAAGGACGAATTACACCCGGAAGATGGACCAGTAATCTTAGATATTGTAGGTACTGGTGGTGACGGACAGAATACTTTTAATGTTTCCACGTCTGCTGCTATCGTTGCCTCCGGAATTCAGGGCCTAAAAATTTGTAAGCACGGTGGTAAAGCTTCTACATCCAATAGTGGAGCTGGTGACCTAATTGGAACTTTAGGCTGTGACATGTTCAAGGTTAATTCATCGACAGTGCCCAAACTTTGGCCTGATAATACGTTCATGTTTCTACTTGCTCCTTTTTTTCATCATGGAATGGGCCACGTTTCTAAGATACGCAAATTTCTTGGAATTCCGACTGTTTTCAACGTACTGGGACCACTTCTACATCCAGTTAGCCACGTAAACAAGAGAATATTGGGCGTTTACTCAAAGGAACTTGCGCCTGAATATGCCAAGGCAGCCGCTTTGGTATATCCAGGAAGCGAAACTTTTATAGTTTGGGGACATGTTGGGTTAGACGAAGTATCACCTATAGGCAAAACTACTGTCTGGCATATTGATCCGACATCGTCCGAACTTAAATTGAAGACCTTCCAATTAGAACCTTCTATGTTTGGTTTAGAAGAACACGAGTTGTCGAAGTGTGCTTCATACGGCCCTAAAGAGAATGCGAGAATTCTAAAAGAAGAAGTCTTGTCCGGCAAGTACCACCTTGGCGACAATAATCCTATTTATGACTACATCTTGATGAACACCGCCGTGTTATATTGTTTAAGCCAAGGTCACCAGAACTGGAAGGAAGGGATCATTAAGGCAGAAGAAAGCATACATTCTGGTAATGCATTACGTTCTTTAGAACACTTTATAGATAGTGTGAGCTCCTTGTAG","protein_sequence":"MSEATLLSYTKKLLASPPQLSSTDLHDALLVILSLLQKCDTNSDESLSIYTKVSSFLTALRVTKLDHKAEYIAEAAKAVLRHSDLVDLPLPKKDELHPEDGPVILDIVGTGGDGQNTFNVSTSAAIVASGIQGLKICKHGGKASTSNSGAGDLIGTLGCDMFKVNSSTVPKLWPDNTFMFLLAPFFHHGMGHVSKIRKFLGIPTVFNVLGPLLHPVSHVNKRILGVYSKELAPEYAKAAALVYPGSETFIVWGHVGLDEVSPIGKTTVWHIDPTSSELKLKTFQLEPSMFGLEEHELSKCASYGPKENARILKEEVLSGKYHLGDNNPIYDYILMNTAVLYCLSQGHQNWKEGIIKAEESIHSGNALRSLEHFIDSVSSL"},{"created_at":"2011-05-26T19:30:07.000Z","updated_at":"2011-07-22T17:53:45.000Z","name":"Kynureninase","uniprot_id":"Q05979","uniprot_name":"KYNU_YEAST","enzyme":true,"transporter":false,"gene_name":"BNA5","num_residues":453,"molecular_weight":"51031.60156","theoretical_pi":"4.94","general_function":"Involved in metabolic process","specific_function":"Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively","reactions":[{"id":1167,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1683,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2572,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"L-kynurenine + H(2)O = anthranilate + L-alanine.","export":false,"pw_reaction_id":null,"source":null},{"id":2573,"direction":"\u003e","locations":"Cytoplasm. Nucleus","altext":"L-3-hydroxykynurenine + H(2)O = 3-hydroxyanthranilate + L-alanine.","export":false,"pw_reaction_id":null,"source":null},{"id":4185,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006486","source":"Smpdb"},{"id":4186,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006534","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Nucleus","genbank_gene_id":"U19027","genbank_protein_id":"609377","gene_card_id":"BNA5","chromosome_location":"chromosome 12","locus":"YLR231C","synonyms":["Biosynthesis of nicotinic acid protein 5","L-kynurenine hydrolase"],"enzyme_classes":["3.7.1.3"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" cofactor binding"},{"category":"Function","description":" pyridoxal phosphate binding"},{"category":"Function","description":" hydrolase activity, acting on acid carbon-carbon bonds"},{"category":"Function","description":" hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances"},{"category":"Function","description":" kynureninase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" coenzyme biosynthetic process"},{"category":"Process","description":" pyridine nucleotide biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nicotinamide nucleotide biosynthetic process"},{"category":"Process","description":" NAD biosynthetic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" indolalkylamine metabolic process"},{"category":"Process","description":" tryptophan metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" tryptophan catabolic process"}],"pfams":[{"name":"Aminotran_5","identifier":"PF00266"}],"pathways":[{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGGAGAAAGCTTTGGAATTAGACGGAGAATATCCGGAATCTCTGAGGGATGAATTCAACATCCCTACATTTAAATCCATGGGACTATCGTCCGACGATAAGCCTGTGACGTACTTATGCGGGAATTCTTTAGGTTTGATGCCGAAGTCAACTAGGAATTCAATTAATGCTGAGCTAGATGCGTGGAGCGATTGTGCTGTGGAATCGCATTTCAAACATCCTGAAGAAGCCAGAGGAAAGGTGCCTTGGGTCAGCATTGACTTACCTATTCTTCCACTACTAGCCCCCATCGTGGGTGCTCAAGAAAATGAAGTTGCAGTAATGAATAGTCTCACTGCAAATTTGAATTCATTGTTAATTACGTTTTATAAACCTACTGAGAAAAGATTCAAGATCCTTTTTGAAAAGGGCTCCTTTCCATCAGACTATTATGCTTTCTACAACCAGTGCAAAATTCATGGAATTTCGGAACCTGAGAATGTTTTTATTCAGATCGAGCCACGCGAGGGAGAGACTTATATCAGAACTCAAGATATCCTGGATACCATAGAGGTAAATCAAGATGAATTGGCGCTGGTCTGTTTGTCAGGTGTTCAGTATTACACGGGGCAATATTTCGATATTGGCCGAATCACCTCATTTGCCCACCAATTCCCCGACATATTGGTTGGATGGGATTTAGCACACGCTGTAGGGAACGTCCCATTGCAACTTCATGATTGGGGTGTTGACTTTGCCTGTTGGTGTTCTTACAAGTACTTGAATGCCGGGCCTGGTGGAATTGGTGGCTTATTTGTCCACTCGAAGCATACTAAACCAGACCCTGCTAAGGAAAGTTTGCCAAGATTAGCTGGTTGGTGGGGCAATGATCCTGCTAAGCGATTTCAAATGCTGGAAGTATTCGAGCCGATTCCAGGAGCATTGGGATTCAGGCAATCTAATCCAAGCGTTATTGACACAGTGGCATTGAGAAGTTCATTGGAATTATTTGCGAAGTTTAATGGTATTAATGAAGTTCGTAAAAGATCGTTGTTGCTGACGAACTATATGACGGAACTGTTGGAAGCCTCCAAGTATTACAAACACCCTTTAAGGATCGAGAAATTACCATGTTTTTTTACAATATTAACTCCAACAAGCACAGATGAAGAACATGGCGCCCAATTGTCACTTTACTTCGATTCTGACACTGGAAAAGAGGATATTATGCCCAAAGTTTTCCAATATTTGCATGACCATGGTGTCATTGGCGATGCAAGAAGACCAAACGTAATTAGATTGGCTCCTGCTCCCTTATATAATACATTTTCAGATGTATACATTGCGGTGAATGCACTAAATGAGGCGATGGATAAGTTGTAG","protein_sequence":"MEKALELDGEYPESLRDEFNIPTFKSMGLSSDDKPVTYLCGNSLGLMPKSTRNSINAELDAWSDCAVESHFKHPEEARGKVPWVSIDLPILPLLAPIVGAQENEVAVMNSLTANLNSLLITFYKPTEKRFKILFEKGSFPSDYYAFYNQCKIHGISEPENVFIQIEPREGETYIRTQDILDTIEVNQDELALVCLSGVQYYTGQYFDIGRITSFAHQFPDILVGWDLAHAVGNVPLQLHDWGVDFACWCSYKYLNAGPGGIGGLFVHSKHTKPDPAKESLPRLAGWWGNDPAKRFQMLEVFEPIPGALGFRQSNPSVIDTVALRSSLELFAKFNGINEVRKRSLLLTNYMTELLEASKYYKHPLRIEKLPCFFTILTPTSTDEEHGAQLSLYFDSDTGKEDIMPKVFQYLHDHGVIGDARRPNVIRLAPAPLYNTFSDVYIAVNALNEAMDKL"},{"created_at":"2011-05-27T05:24:20.000Z","updated_at":"2011-05-27T15:01:24.000Z","name":"Probable kynurenine formamidase","uniprot_id":"Q04066","uniprot_name":"BNA7_YEAST","enzyme":true,"transporter":false,"gene_name":"BNA7","num_residues":261,"molecular_weight":"29991.0","theoretical_pi":"4.98","general_function":"Involved in hydrolase activity","specific_function":"Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the conversion of tryptophan to nicotinic acid, NAD(H) and NADP(H)","reactions":[{"id":2770,"direction":"\u003e","locations":"Cytoplasmic","altext":"N-formyl-L-kynurenine + H(2)O = formate + L-kynurenine.","export":false,"pw_reaction_id":null,"source":null},{"id":4188,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006488","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1VKH","cellular_location":"Cytoplasmic","genbank_gene_id":"U33007","genbank_protein_id":"927719","gene_card_id":"BNA7","chromosome_location":"chromosome 4","locus":"YDR428C","synonyms":["Biosynthesis of nicotinic acid protein 7","Probable N-formylkynurenine formamidase"],"enzyme_classes":["3.5.1.9"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Abhydrolase_3","identifier":"PF07859"}],"pathways":[{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"NAD metabolism","kegg_map_id":null}],"gene_sequence":"ATGTCAAATACCGTAAGAGCCATTTCACCAGATATAACACTATTCAACAAGACATTGACATTCCAAGAAATCTCACAAAACACTAGAGAGGCTGTCATATACATTCATGGAGGTGCATGGAACGATCCTGAGAATACGCCCAATGATTTTAATCAATTAGCCAATACCATCAAATCAATGGATACTGAGTCAACGGTTTGTCAATACTCTATAGAATACAGGTTATCACCAGAGATCACAAATCCAAGAAACTTATATGATGCTGTGTCAAATATAACAAGGCTTGTTAAAGAAAAGGGATTAACGAACATTAATATGGTGGGACATTCCGTTGGAGCTACCTTTATTTGGCAGATATTAGCTGCACTCAAAGATCCTCAAGAAAAAATGAGTGAAGCGCAATTGCAAATGTTGGGACTTTTGCAGATCGTGAAGAGAGTATTTCTATTGGATGGTATATACTCGTTAAAGGAACTGTTGGTAGAATACCCAGAGTATGATTGTTTTACAAGACTTGCCTTCCCTGATGGTATTCAAATGTACGAGGAAGAGCCCTCGAGAGTAATGCCTTACGTGAAGAAAGCCCTTTCTCGCTTCAGTATTGATATGCACCTAGTGCATTCTTATAGCGACGAGTTATTAACGTTAAGACAAACTAATTGTTTAATTTCTTGTCTTCAGGATTATCAGTTAAGTTTCAAGTTGTATTTGGACGATTTGGGTTTGCATAATGATGTTTATAAGAATGGTAAAGTTGCGAAGTATATTTTTGACAATATTTGTTGA","protein_sequence":"MSNTVRAISPDITLFNKTLTFQEISQNTREAVIYIHGGAWNDPENTPNDFNQLANTIKSMDTESTVCQYSIEYRLSPEITNPRNLYDAVSNITRLVKEKGLTNINMVGHSVGATFIWQILAALKDPQEKMSEAQLQMLGLLQIVKRVFLLDGIYSLKELLVEYPEYDCFTRLAFPDGIQMYEEEPSRVMPYVKKALSRFSIDMHLVHSYSDELLTLRQTNCLISCLQDYQLSFKLYLDDLGLHNDVYKNGKVAKYIFDNIC"}]}