2-methylbutan-1-ol (YMDB00567)

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Identification

YMDB ID

YMDB00567

Name

2-methylbutan-1-ol

Species

Saccharomyces cerevisiae

Strain

Baker's yeast

Description

(S)-2-Methyl-1-butanol, also known as sec-butylcarbinol or 2-methyl butanol-1, belongs to the class of organic compounds known as primary alcohols. Primary alcohols are compounds comprising the primary alcohol functional group, with the general structure RCOH (R=alkyl, aryl). Thus, (S)-2-methyl-1-butanol is considered to be a fatty alcohol lipid molecule (S)-2-Methyl-1-butanol is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral (S)-2-Methyl-1-butanol exists in all eukaryotes, ranging from yeast to humans (S)-2-methyl-1-butanol can be biosynthesized from ()-2-methylbutanal; which is mediated by the enzyme alcohol dehydrogenase. In yeast, (S)-2-methyl-1-butanol is involved in the metabolic pathway called the isoleucine degradation pathway.

Structure

MOL SDF PDB SMILES InChI

Synonyms

1-Butanol, 2-methyl-
2-Methyl butanol-1
2-Methyl-1-butanol
2-methyl-butan-1-ol
2-Methyl-n-butanol
2-Methylbutanol
2-Methylbutyl alcohol
3-methyl iso-butanol
Active Amyl alcohol
Active primary amyl alcohol
Butanol, 2-methyl-
dl-2-Methyl-1-butanol
dl-sec-Butyl carbinol
L-2-Methyl-1-butanol
Methyl-2-butan-1-ol
Primary active amyl alcohol
sec-Butylcarbinol
CH3CH2CH(CH3)CH2OH
(+/-)-2-methyl-1-butanol
(1)-2-Methylbutan-1-ol
(S)-(-)-2-Methyl-1-butanol
(S)-2-Methylbutan-1-ol
2-Methyl-(.+/-.)-1-butanol
2-Methyl-(2S)-1-butanol
2-Methyl-(S)-1-butanol
2-Methylbutan-1-ol
D-2-METHYL-1-butanol
DL-2-METHYL-1-butanol, pract
Sec-butyl carbinol

CAS number

137-32-6

Weight

Average: 88.1482
Monoisotopic: 88.088815006

InChI Key

QPRQEDXDYOZYLA-UHFFFAOYSA-N

InChI

InChI=1S/C5H12O/c1-3-5(2)4-6/h5-6H,3-4H2,1-2H3

IUPAC Name

2-methylbutan-1-ol

Traditional IUPAC Name

2-methyl-1-butanol

Chemical Formula

C₅H₁₂O

SMILES

CCC(C)CO

Chemical Taxonomy

Description

belongs to the class of organic compounds known as primary alcohols. Primary alcohols are compounds comprising the primary alcohol functional group, with the general structure RCOH (R=alkyl, aryl).

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Alcohols and polyols

Direct Parent

Primary alcohols

Alternative Parents

Hydrocarbon derivatives

Substituents

Hydrocarbon derivative
Primary alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

primary alcohol (CHEBI:48945 )
alkyl alcohol (CHEBI:48945 )
Fatty alcohols (LMFA05000104 )
a small molecule (CPD-7033 )

Physical Properties

State

Solid

Charge

Melting point

Not Available

Experimental Properties

Property	Value	Reference
Water Solubility	29.7 mg/mL at 25 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]	PhysProp
LogP	1.29 [VALVANI,SC ET AL. (1981)]	PhysProp

Predicted Properties

Property	Value	Source
Water Solubility	42 g/L	ALOGPS
logP	1.24	ALOGPS
logP	1.17	ChemAxon
logS	-0.32	ALOGPS
pKa (Strongest Acidic)	17.5	ChemAxon
pKa (Strongest Basic)	-1.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	20.23 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	26.61 m³·mol⁻¹	ChemAxon
Polarizability	10.99 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Biological Properties

Cellular Locations

extracellular
mitochondrion
cytoplasm

Organoleptic Properties

Flavour/Odour	Source
Malt	FDB008130

SMPDB Pathways

Isoleucine degradation

PW002491

KEGG Pathways

Not Available

SMPDB Reactions

2-Methylbutanal + NADH + hydron → 2-methylbutan-1-ol + NAD

KEGG Reactions

Acetyl-CoA + 2-methylbutan-1-ol → 2-Methylbutyl acetate + Coenzyme A

2-Methylbutanal + NADH + hydron → NAD + 2-methylbutan-1-ol

2-Methylbutanal + NADPH + hydron → NADP + 2-methylbutan-1-ol

Concentrations

Intracellular Concentrations

Not Available

Extracellular Concentrations

Not Available

Spectra

References

References:

Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). "A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology." Nat Biotechnol 26:1155-1160.18846089
Ford, G., Ellis, E. M. (2002). "Characterization of Ypr1p from Saccharomyces cerevisiae as a 2-methylbutyraldehyde reductase." Yeast 19:1087-1096.12210903
Leskovac, V., Trivic, S., Pericin, D. (2002). "The three zinc-containing alcohol dehydrogenases from baker's yeast, Saccharomyces cerevisiae." FEMS Yeast Res 2:481-494.12702265
Chi, A., Huttenhower, C., Geer, L. Y., Coon, J. J., Syka, J. E., Bai, D. L., Shabanowitz, J., Burke, D. J., Troyanskaya, O. G., Hunt, D. F. (2007). "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Proc Natl Acad Sci U S A 104:2193-2198.17287358
Verstrepen, K. J., Van Laere, S. D., Vanderhaegen, B. M., Derdelinckx, G., Dufour, J. P., Pretorius, I. S., Winderickx, J., Thevelein, J. M., Delvaux, F. R. (2003). "Expression levels of the yeast alcohol acetyltransferase genes ATF1, Lg-ATF1, and ATF2 control the formation of a broad range of volatile esters." Appl Environ Microbiol 69:5228-5237.12957907
Larroy, C., Pares, X., Biosca, J. A. (2002). "Characterization of a Saccharomyces cerevisiae NADP(H)-dependent alcohol dehydrogenase (ADHVII), a member of the cinnamyl alcohol dehydrogenase family." Eur J Biochem 269:5738-5745.12423374
Dickinson, J. R., Salgado, L. E., Hewlins, M. J. (2003). "The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae." J Biol Chem 278:8028-8034.12499363

Synthesis Reference:

Not Available

External Links:

Resource	Link
CHEBI ID	48945
HMDB ID	HMDB0031527
Pubchem Compound ID	8723
Kegg ID	Not Available
ChemSpider ID	8398
FOODB ID	FDB008130
Wikipedia ID	Not Available
BioCyc ID	Not Available

Enzymes

Protein Details

1. Alcohol dehydrogenase 3, mitochondrial

General function:: Involved in zinc ion binding
Specific function:: An alcohol + NAD(+) = an aldehyde or ketone + NADH
Gene Name:: ADH3
Uniprot ID:: P07246
Molecular weight:: 40369.19922

Reactions

An alcohol + NAD(+) → an aldehyde or ketone + NADH.

Protein Details

2. S-(hydroxymethyl)glutathione dehydrogenase

General function:: Involved in zinc ion binding
Specific function:: Oxidizes long-chain alcohols and, in the presence of glutathione, is able to oxidize formaldehyde. Is responsible for yeast resistance to formaldehyde
Gene Name:: SFA1
Uniprot ID:: P32771
Molecular weight:: 41041.69922

Reactions

S-(hydroxymethyl)glutathione + NAD(P)(+) → S-formylglutathione + NAD(P)H.
An alcohol + NAD(+) → an aldehyde or ketone + NADH.

Protein Details

3. Alcohol dehydrogenase 1

General function:: Involved in zinc ion binding
Specific function:: This isozyme preferentially catalyzes the conversion of primary unbranched alcohols to their corresponding aldehydes. Also also shows activity toward secondary alcohols
Gene Name:: ADH1
Uniprot ID:: P00330
Molecular weight:: 36849.0

Reactions

An alcohol + NAD(+) → an aldehyde or ketone + NADH.

Protein Details

4. Alcohol dehydrogenase 4

General function:: Involved in oxidoreductase activity
Specific function:: Reduces acetaldehyde to ethanol during glucose fermentation. Specific for ethanol. Shows drastically reduced activity towards primary alcohols from 4 carbon atoms upward. Isomers of aliphatic alcohol, as well as secondary alcohols and glycerol are not used at all
Gene Name:: ADH4
Uniprot ID:: P10127
Molecular weight:: 41141.69922

Reactions

An alcohol + NAD(+) → an aldehyde or ketone + NADH.

Protein Details

5. Alcohol dehydrogenase 5

General function:: Involved in zinc ion binding
Specific function:: An alcohol + NAD(+) = an aldehyde or ketone + NADH
Gene Name:: ADH5
Uniprot ID:: P38113
Molecular weight:: 37647.89844

Reactions

An alcohol + NAD(+) → an aldehyde or ketone + NADH.

Protein Details

6. Alcohol dehydrogenase 2

General function:: Involved in zinc ion binding
Specific function:: This isozyme preferentially catalyzes the conversion of ethanol to acetaldehyde. Acts on a variety of primary unbranched aliphatic alcohols
Gene Name:: ADH2
Uniprot ID:: P00331
Molecular weight:: 36731.60156

Reactions

An alcohol + NAD(+) → an aldehyde or ketone + NADH.

Protein Details

7. Alcohol O-acetyltransferase 1

General function:: Involved in alcohol O-acetyltransferase activity
Specific function:: Catalyzes the esterification of isoamyl alcohol and various other alcohols by acetyl-CoA
Gene Name:: ATF1
Uniprot ID:: P40353
Molecular weight:: 61035.5

Reactions

Acetyl-CoA + an alcohol → CoA + an acetyl ester.

Protein Details

8. Alcohol O-acetyltransferase 2

General function:: Involved in alcohol O-acetyltransferase activity
Specific function:: Acetyl-CoA + an alcohol = CoA + an acetyl ester
Gene Name:: ATF2
Uniprot ID:: P53296
Molecular weight:: 61897.5

Reactions

Acetyl-CoA + an alcohol → CoA + an acetyl ester.

Protein Details

9. NADP-dependent alcohol dehydrogenase 7

General function:: Involved in zinc ion binding
Specific function:: NADP-dependent alcohol dehydrogenase with a broad substrate specificity
Gene Name:: ADH7
Uniprot ID:: P25377
Molecular weight:: 39348.19922

Reactions

An alcohol + NADP(+) → an aldehyde + NADPH.

Protein Details

10. Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2

General function:: Involved in enzyme regulator activity
Specific function:: Required for calcium regulation. May regulate calcium accumulation by a non-vacuole organelle. Also regulates the activity of CSH1 and SUR1 during mannosyl phosphorylinositol ceramide synthesis
Gene Name:: CSG2
Uniprot ID:: P35206
Molecular weight:: 45441.60156

Reactions

Protein Details

11. NADP-dependent alcohol dehydrogenase 6

General function:: Involved in zinc ion binding
Specific function:: NADP-dependent alcohol dehydrogenase with a broad substrate specificity
Gene Name:: ADH6
Uniprot ID:: Q04894
Molecular weight:: 39617.30078

Reactions

An alcohol + NADP(+) → an aldehyde + NADPH.

Protein Details

12. Putative reductase 1

General function:: Involved in oxidoreductase activity
Specific function:: Not Available
Gene Name:: YPR1
Uniprot ID:: Q12458
Molecular weight:: 34754.69922

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Structure for #<Compound:0xb4e771c4>

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