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Glutathione metabolism

SourceIDPathway
PathWhizPW002395 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG00480 Map00480

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB00016Glycine
56-40-6
2-aminoacetic acidC2H5NO2
75.0666
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YMDB00046L-Cysteine
52-90-4
(2R)-2-amino-3-sulfanylpropanoic acidC3H7NO2S
121.158
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YMDB00057Oxidized glutathione
27025-41-8
2-amino-4-[(2-{[2-(4-amino-4-carboxybutanamido)-2-[(carboxymethyl)carbamoyl]ethyl]disulfanyl}-1-[(carboxymethyl)carbamoyl]ethyl)carbamoyl]butanoic acidC20H32N6O12S2
612.631
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YMDB00107Pyroglutamic acid
98-79-3
(2S)-5-oxopyrrolidine-2-carboxylic acidC5H7NO3
129.114
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YMDB00109Adenosine triphosphate
56-65-5
({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidC10H16N5O13P3
507.181
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YMDB00132Putrescine
110-60-1
butane-1,4-diamineC4H12N2
88.1515
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YMDB00160Glutathione
70-18-8
(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acidC10H17N3O6S
307.323
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YMDB00231Spermine
71-44-3
(3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amineC10H26N4
202.3402
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YMDB00232Spermidine
124-20-9
(4-aminobutyl)(3-aminopropyl)amineC7H19N3
145.2459
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YMDB00252Gamma-Glutamylcysteine
636-58-8
(2S)-2-amino-4-{[(1R)-1-carboxy-2-sulfanylethyl]carbamoyl}butanoic acidC8H14N2O5S
250.272
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YMDB00271L-Glutamic acid
56-86-0
(2S)-2-aminopentanedioic acidC5H9NO4
147.1293
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YMDB00312Acetyl-CoA
72-89-9
{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC23H38N7O17P3S
809.571
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YMDB00426NADPH
53-57-6
{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC21H30N7O17P3
745.4209
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YMDB00427NADP
53-59-8
1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1λ⁵-pyridin-1-yliumC21H29N7O17P3
744.4129
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YMDB00690L-cysteinylglycine
70-18-8
2-[(2R)-2-amino-3-sulfanylpropanamido]acetic acidC5H10N2O3S
178.21
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YMDB00691L-gamma-Glutamyl-L-alanine
5875-41-2
(2S)-2-amino-4-{[(1S)-1-carboxyethyl]carbamoyl}butanoic acidC8H14N2O5
218.2072
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YMDB00693glutathione disulfide
27025-41-8
(2S)-2-amino-4-{[(1R)-2-{[(2R)-2-[(4S)-4-amino-4-carboxybutanamido]-2-[(carboxymethyl)carbamoyl]ethyl]disulfanyl}-1-[(carboxymethyl)carbamoyl]ethyl]carbamoyl}butanoic acidC20H32N6O12S2
612.631
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YMDB00862hydron
12408-02-5
hydronH
1.00794
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YMDB00890water
7732-18-5
waterH2O
18.0153
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YMDB00907phosphate
14265-44-2
phosphoric acidO4P
94.9714
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YMDB00914ADP
58-64-0
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acidC10H15N5O10P2
427.2011
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Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P38143GPX2
YBR244W
Glutathione peroxidase 2Enzyme
Q08220GSH2
YOL049W
Glutathione synthetaseEnzyme
P53982IDP3
YNL009W
Isocitrate dehydrogenase [NADP]Enzyme
P21954IDP1
YDL066W
Isocitrate dehydrogenase [NADP], mitochondrialEnzyme
P41939IDP2
YLR174W
Isocitrate dehydrogenase [NADP] cytoplasmicEnzyme
P32477GSH1
YJL101C
Glutamate--cysteine ligaseEnzyme
P41921GLR1
YPL091W
Glutathione reductaseEnzyme
P36014GPX1
YKL026C
Glutathione peroxidase 1Enzyme
P09938RNR2
YJL026W
Ribonucleoside-diphosphate reductase small chain 1Enzyme
P21524RNR1
YER070W
Ribonucleoside-diphosphate reductase large chain 1Enzyme
Q12455SPE4
YLR146C
Spermine synthaseEnzyme
Q12074SPE3
YPR069C
Spermidine synthaseEnzyme
P08432SPE1
YKL184W
Ornithine decarboxylaseEnzyme
Q05902ECM38
YLR299W
Gamma-glutamyltransferaseEnzyme
P36156ECM4
YKR076W
Glutathione S-transferase omega-like 2Enzyme
Q04806GTO3
YMR251W
Glutathione S-transferase omega-like 3Enzyme
Q12390GTT2
YLL060C
Glutathione S-transferase 2Enzyme
P48239GTO1
YGR154C
Glutathione S-transferase omega-like 1Enzyme
P40581HYR1
YIR037W
Peroxiredoxin HYR1Enzyme
P40582GTT1
YIR038C
Glutathione S-transferase 1Enzyme
P38720GND1
YHR183W
6-phosphogluconate dehydrogenase, decarboxylating 1Enzyme
P53319GND2
YGR256W
6-phosphogluconate dehydrogenase, decarboxylating 2Enzyme
P49723RNR4
YGR180C
Ribonucleoside-diphosphate reductase small chain 2Enzyme
P11412ZWF1
YNL241C
Glucose-6-phosphate 1-dehydrogenaseEnzyme
P21672RNR3
Ribonucleoside-diphosphate reductase large chain 2Enzyme
P43616DUG1
Cys-Gly metallodipeptidase DUG1