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Identification
YMDB IDYMDB00907
Namephosphate
SpeciesSaccharomyces cerevisiae
StrainBaker's yeast
DescriptionInorganic phosphate (Pi) is the phosphorus ion found in biological systems. Inorganic phosphate is released in biochemical reactions involving the hydrolysis of ATP or ADP.
Structure
Thumb
Synonyms
  • [Pyruvate dehydrogenase (acetyl-transferring)] phosphate
  • Biphosphate
  • Hydrogen orthophosphate
  • Hydrogen phosphate
  • Hydrogen phosphate anion
  • Hydrogen phosphate dianion
  • Hydrogen phosphate ion
  • HYDROGENPHOSPHATE ION
  • Monohydrogen phosphate
  • NFB Orthophosphate
  • O-phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
  • Phosphate
  • Phosphate (PO43-)
  • Phosphate anion(3-)
  • Phosphate dianion
  • Phosphate ion
  • Phosphate ion (PO43-)
  • Phosphate ion(3-)
  • Phosphate trianion
  • Phosphate(3-)
  • Phosphoric acid ion
  • Phosphoric acid ion(3-)
  • Pi
  • [PO(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
  • Phosphorsaeureloesungen
  • Phosphorsaeure
  • Phosphoric acid
  • Orthophosphate
  • Condact
  • Uni-etch
  • Concise etchant
  • K-Etchant
  • Diphosphate tetrasodium
  • Marphos
  • NFB
  • ortho- Phosphoric acid
  • Phosphoric acid (acd/name 4.0)
  • Sodium pyrophosphate
  • Sodium pyrophosphate decahydrate
  • Sodium pyrophosphate decahydrate biochemica
  • Sonac
  • Tetra-sodium pyrophosphate
  • Tetrasodium pyrophosphate 10-hydrate
  • Tetrasodium pyrophosphate decahydrate
  • White phosphoric acid
CAS number14265-44-2
WeightAverage: 94.9714
Monoisotopic: 94.95342
InChI KeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
IUPAC Namephosphoric acid
Traditional IUPAC Namephosphoric acid
Chemical FormulaO4P
SMILES[O-]P([O-])([O-])=O
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as non-metal phosphates. These are inorganic non-metallic compounds containing a phosphate as its largest oxoanion.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassNon-metal oxoanionic compounds
Sub ClassNon-metal phosphates
Direct ParentNon-metal phosphates
Alternative Parents
Substituents
  • Non-metal phosphate
  • Inorganic oxide
Molecular FrameworkNot Available
External Descriptors
Physical Properties
StateSolid
Charge0
Melting point42.35 °C
Experimental Properties
PropertyValueReference
Water Solubility1000 mg/mL [MERCK INDEX (1996); freely soluble]PhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
logP-1ChemAxon
pKa (Strongest Acidic)1.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area77.76 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity14.65 m³·mol⁻¹ChemAxon
Polarizability5.81 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations
  • Cytoplasm
  • Endoplasmic Reticulum
  • Extracellular
  • Golgi
  • Mitochondrion
  • Nucleus
  • Peroxisome
  • Vacuole
Organoleptic PropertiesNot Available
SMPDB Pathways
Biotin BiosynthesisPW002380 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin BiosynthesisPW002431 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/10:0/10:0/28:0)PW003484 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/10:0/10:0/30:0)PW003501 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/10:0/12:0/26:0)PW003502 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Glutathione metabolismec00480 Map00480
Glycerophospholipid metabolismec00564 Map00564
Inositol phosphate metabolismec00562 Map00562
Nitrogen metabolismec00910 Map00910
Oxidative phosphorylationec00190 Map00190
SMPDB Reactions
Succinyl-CoA + phosphate + Guanosine diphosphateSuccinic acid + Coenzyme A + GTP
Adenosine triphosphate + itaconic acid + Coenzyme AADP + phosphate + itaconyl-CoA
Adenosine triphosphate + Pyruvic acid + Hydrogen carbonateADP + phosphate + Oxalacetic acid
L-Glutamic acid 5-phosphate + hydron + NADPHl-Glutamic-gamma-semialdehyde + NADP + phosphate
D-Alanine + Adenosine triphosphate → D-Alanyl-D-alanine + ADP + phosphate
KEGG Reactions
5-(methylsulfanyl)-2,3-dioxopentyl phosphate + waterhydron + 4-Methylthio-2-oxobutanoate + phosphate + Formic acid
D-Erythrose 4-phosphate + Phosphoenolpyruvic acid + waterphosphate + 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid
Adenosine 3',5'-diphosphate + waterAdenosine monophosphate + phosphate
7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid3-Dehydroquinate + phosphate
Phosphoenolpyruvic acid + 3-Phosphoshikimic acidphosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimic acid
Concentrations
Intracellular Concentrations
Intracellular ConcentrationSubstrateGrowth ConditionsStrainCitation
22000 ± 1000 µM Synthetic medium with 2% glucoseaerobic;growing cellsBaker's yeastPMID: 6229402
19000 ± 1000 µM Synthetic medium with 2% glucoseaerobic;resting cellsBaker's yeastPMID: 6229402
23000 ± 4000 µM Synthetic medium with 2% glucoseanaerobic;resting cellsBaker's yeastPMID: 6229402
15000 ± 4000 µM Synthetic medium with 2% galactoseaerobic;resting cellsBaker's yeastPMID: 6229402
Conversion Details Here
Extracellular ConcentrationsNot Available
Spectra
Spectra
References
References:
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Synthesis Reference:Cremer, Josef; Hartmann, Fridolin; Rodis, Franz; Hinz, Arnulf. Preparation of alkali or alkaline earth phosphates with simultaneous recovery of volatile mineral acids. Ger. (1966), 2 pp. CODEN: GWXXAW DE 1227435 19661027 CAN 66:12584 AN 196
External Links:
ResourceLink
CHEBI ID18367
HMDB IDHMDB01429
Pubchem Compound ID1061
Kegg IDC00009
ChemSpider ID1032
FOODB IDFDB022848
WikipediaPhosphate
BioCyc IDCPD-8587

Enzymes

General function:
Involved in catalytic activity
Specific function:
Non-essential protein which is required for efficient N- glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate
Gene Name:
CAX4
Uniprot ID:
P53223
Molecular weight:
27648.80078
Reactions
Dolichyl diphosphate + H(2)O → dolichyl phosphate + phosphate.
General function:
Involved in catalytic activity
Specific function:
ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate
Gene Name:
ADE6
Uniprot ID:
P38972
Molecular weight:
148904.0
Reactions
ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O → ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.
General function:
Involved in catalytic activity
Specific function:
2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
Gene Name:
CPA1
Uniprot ID:
P07258
Molecular weight:
45361.19922
Reactions
2 ATP + L-glutamine + HCO(3)(-) + H(2)O → 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.
General function:
Involved in carboxyl- or carbamoyltransferase activity
Specific function:
This protein is a "fusion" protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase)
Gene Name:
URA2
Uniprot ID:
P07259
Molecular weight:
245124.0
Reactions
2 ATP + L-glutamine + HCO(3)(-) + H(2)O → 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.
Carbamoyl phosphate + L-aspartate → phosphate + N-carbamoyl-L-aspartate.
General function:
Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Specific function:
Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln). Required for HMG2-induced ER-remodeling
Gene Name:
HER2
Uniprot ID:
Q03557
Molecular weight:
50918.0
Reactions
ATP + L-glutamyl-tRNA(Gln) + L-glutamine → ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.
General function:
Involved in ATP binding
Specific function:
2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
Gene Name:
CPA2
Uniprot ID:
P03965
Molecular weight:
123914.0
Reactions
2 ATP + L-glutamine + HCO(3)(-) + H(2)O → 2 ADP + phosphate + L-glutamate + carbamoyl phosphate.
General function:
Involved in CTP synthase activity
Specific function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen
Gene Name:
URA7
Uniprot ID:
P28274
Molecular weight:
64709.80078
Reactions
ATP + UTP + NH(3) → ADP + phosphate + CTP.
General function:
Involved in glutamate-ammonia ligase activity
Specific function:
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine
Gene Name:
GLN1
Uniprot ID:
P32288
Molecular weight:
41705.60156
Reactions
ATP + L-glutamate + NH(3) → ADP + phosphate + L-glutamine.
General function:
Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Specific function:
Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln)
Gene Name:
PET112
Uniprot ID:
P33893
Molecular weight:
61842.19922
Reactions
ATP + L-glutamyl-tRNA(Gln) + L-glutamine → ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.
General function:
Involved in CTP synthase activity
Specific function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Plays an important role in the regulation of phospholipid synthesis
Gene Name:
URA8
Uniprot ID:
P38627
Molecular weight:
63055.69922
Reactions
ATP + UTP + NH(3) → ADP + phosphate + CTP.
General function:
Involved in ATP binding
Specific function:
Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln)
Gene Name:
Not Available
Uniprot ID:
P53260
Molecular weight:
20786.80078
Reactions
ATP + L-glutamyl-tRNA(Gln) + L-glutamine → ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.
General function:
Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Specific function:
Hydrolysis of urea to ammonia and CO(2)
Gene Name:
DUR1
Uniprot ID:
P32528
Molecular weight:
201830.0
Reactions
ATP + urea + HCO(3)(-) → ADP + phosphate + urea-1-carboxylate.
Urea-1-carboxylate + H(2)O → 2 CO(2) + 2 NH(3).
General function:
Involved in ATP adenylyltransferase activity
Specific function:
Ap4A phosphorylase catabolizes Ap4N nucleotides (where N is A,C,G or U). Additionally this enzyme catalyzes the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulfate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP
Gene Name:
APA1
Uniprot ID:
P16550
Molecular weight:
36492.19922
Reactions
ADP + ATP → phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate.
ADP + sulfate → phosphate + adenylyl sulfate.
Adenylylsulfate + ATP → P(1),P(4)-bis(5'-adenosyl)tetraphosphate + sulfate.
General function:
Involved in catalytic activity
Specific function:
Phosphatase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process
Gene Name:
TPS2
Uniprot ID:
P31688
Molecular weight:
102976.0
Reactions
Trehalose 6-phosphate + H(2)O → trehalose + phosphate.
General function:
Involved in catalytic activity
Specific function:
This is predominantly if not solely a fructose-2,6- bisphosphatase
Gene Name:
FBP26
Uniprot ID:
P32604
Molecular weight:
52594.5
Reactions
Beta-D-fructose 2,6-bisphosphate + H(2)O → D-fructose 6-phosphate + phosphate.
General function:
Involved in catalytic activity
Specific function:
Synthesis and degradation of fructose 2,6-bisphosphate
Gene Name:
Not Available
Uniprot ID:
Q06137
Molecular weight:
58385.19922
Reactions
Beta-D-fructose 2,6-bisphosphate + H(2)O → D-fructose 6-phosphate + phosphate.
ATP + D-fructose 6-phosphate → ADP + beta-D-fructose 2,6-bisphosphate.
General function:
Involved in adenylosuccinate synthase activity
Specific function:
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP
Gene Name:
ADE12
Uniprot ID:
P80210
Molecular weight:
48279.10156
Reactions
GTP + IMP + L-aspartate → GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.
General function:
Involved in hydrolase activity
Specific function:
May eliminate potentially toxic dinucleoside polyphosphates during sporulation. Most active against diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A). Can also hydrolyze diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A), adenosine 5'-pentaphosphate, and adenosine 5'-tetraphosphate are also substrates, but not diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) or other dinucleotides, mononucleotides, nucleotide sugars, or nucleotide alcohols. Also cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate)
Gene Name:
DDP1
Uniprot ID:
Q99321
Molecular weight:
21572.30078
Reactions
Diphospho-myo-inositol polyphosphate + H(2)O → myo-inositol polyphosphate + phosphate.
General function:
Involved in ATP binding
Specific function:
ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
Gene Name:
GSH2
Uniprot ID:
Q08220
Molecular weight:
55814.69922
Reactions
ATP + gamma-L-glutamyl-L-cysteine + glycine → ADP + phosphate + glutathione.
General function:
Involved in catalytic activity
Specific function:
ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide
Gene Name:
ADE5
Uniprot ID:
P07244
Molecular weight:
86067.39844
Reactions
ATP + 5-phospho-D-ribosylamine + glycine → ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.
ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine → ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.
General function:
Involved in catalytic activity
Specific function:
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)
Gene Name:
UTR4
Uniprot ID:
P32626
Molecular weight:
25187.19922
Reactions
5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O → 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate.
2-Phosphoglycolate + H2O → glycolate + phosphate
General function:
Involved in phosphatase activity
Specific function:
Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing
Gene Name:
POA1
Uniprot ID:
P38218
Molecular weight:
19937.59961
Reactions
ADP-ribose 1''-phosphate + H(2)O → ADP-ribose + phosphate.
General function:
Involved in phosphatase activity
Specific function:
Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing
Gene Name:
Not Available
Uniprot ID:
Q04299
Molecular weight:
32067.0
Reactions
ADP-ribose 1''-phosphate + H(2)O → ADP-ribose + phosphate.
General function:
Involved in 3-dehydroquinate dehydratase activity
Specific function:
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis
Gene Name:
ARO1
Uniprot ID:
P08566
Molecular weight:
174754.0
Reactions
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate → 3-dehydroquinate + phosphate.
3-dehydroquinate → 3-dehydroshikimate + H(2)O.
Shikimate + NADP(+) → 3-dehydroshikimate + NADPH.
ATP + shikimate → ADP + shikimate 3-phosphate.
Phosphoenolpyruvate + 3-phosphoshikimate → phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.
General function:
Involved in catalytic activity
Specific function:
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Gene Name:
ARO4
Uniprot ID:
P32449
Molecular weight:
39748.80078
Reactions
Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O → 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
General function:
Involved in catalytic activity
Specific function:
Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Gene Name:
ARO3
Uniprot ID:
P14843
Molecular weight:
41069.5
Reactions
Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O → 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
General function:
Involved in purine-nucleoside phosphorylase activity
Specific function:
Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules
Gene Name:
PNP1
Uniprot ID:
Q05788
Molecular weight:
33754.60156
Reactions
Purine nucleoside + phosphate → purine + alpha-D-ribose 1-phosphate.
General function:
Involved in aspartate-semialdehyde dehydrogenase activity
Specific function:
This enzyme catalyzes the second step in the common metabolic pathway to synthesize Thr and Met from Asp
Gene Name:
HOM2
Uniprot ID:
P13663
Molecular weight:
39543.30078
Reactions
L-aspartate 4-semialdehyde + phosphate + NADP(+) → L-4-aspartyl phosphate + NADPH.
General function:
Involved in catalytic activity
Specific function:
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
Gene Name:
LSC1
Uniprot ID:
P53598
Molecular weight:
35032.19922
Reactions
ATP + succinate + CoA → ADP + phosphate + succinyl-CoA.
General function:
Involved in catalytic activity
Specific function:
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
Gene Name:
LSC2
Uniprot ID:
P53312
Molecular weight:
46900.30078
Reactions
ATP + succinate + CoA → ADP + phosphate + succinyl-CoA.
General function:
Involved in glutamate-cysteine ligase activity
Specific function:
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
Gene Name:
GSH1
Uniprot ID:
P32477
Molecular weight:
78252.89844
Reactions
ATP + L-glutamate + L-cysteine → ADP + phosphate + gamma-L-glutamyl-L-cysteine.
General function:
Involved in acetylglutamate kinase activity
Specific function:
N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH
Gene Name:
ARG5
Uniprot ID:
Q01217
Molecular weight:
94868.39844
Reactions
N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate → N-acetyl-5-glutamyl phosphate + NADPH.
ATP + N-acetyl-L-glutamate → ADP + N-acetyl-L-glutamate 5-phosphate.
General function:
Involved in hydrolase activity
Specific function:
Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Has equal high activity toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate. Has no activity toward GMP. Required for Golgi glycosylation and cell wall integrity. Together with CDC55, required for adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity, the apyrase activity is not required for this function. Plays a role in sphingolipid synthesis
Gene Name:
YND1
Uniprot ID:
P40009
Molecular weight:
71851.20313
Reactions
ATP + 2 H(2)O → AMP + 2 phosphate.
General function:
Involved in carboxyl- or carbamoyltransferase activity
Specific function:
Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline
Gene Name:
ARG3
Uniprot ID:
P05150
Molecular weight:
37844.80078
Reactions
Carbamoyl phosphate + L-ornithine → phosphate + L-citrulline.
General function:
Involved in phosphoribosylaminoimidazole carboxylase activity
Specific function:
5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)
Gene Name:
ADE2
Uniprot ID:
P21264
Molecular weight:
62338.69922
Reactions
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate → 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).
General function:
Involved in catalytic activity
Specific function:
Glycerol 3-phosphate + H(2)O = glycerol + phosphate
Gene Name:
HOR2
Uniprot ID:
P40106
Molecular weight:
27813.5
Reactions
Glycerol 3-phosphate + H(2)O → glycerol + phosphate.
glycerol 1-phosphate + H2O → glycerol + phosphate
General function:
Involved in catalytic activity
Specific function:
Glycerol 3-phosphate + H(2)O = glycerol + phosphate
Gene Name:
RHR2
Uniprot ID:
P41277
Molecular weight:
27946.59961
Reactions
Glycerol 3-phosphate + H(2)O → glycerol + phosphate.
glycerol 1-phosphate + H2O → glycerol + phosphate
General function:
Involved in magnesium ion binding
Specific function:
ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin
Gene Name:
BIO4
Uniprot ID:
P53630
Molecular weight:
26256.69922
Reactions
ATP + 7,8-diaminononanoate + CO(2) → ADP + phosphate + dethiobiotin.
General function:
Involved in ATP binding
Specific function:
ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate
Gene Name:
ADE1
Uniprot ID:
P27616
Molecular weight:
34603.10156
Reactions
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate → ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.
General function:
Involved in phosphoric ester hydrolase activity
Specific function:
D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate
Gene Name:
FBP1
Uniprot ID:
P09201
Molecular weight:
38262.19922
Reactions
D-fructose 1,6-bisphosphate + H(2)O → D-fructose 6-phosphate + phosphate.
General function:
Involved in tetrahydrofolylpolyglutamate synthase activity
Specific function:
Conversion of folates to polyglutamate derivatives
Gene Name:
FOL3
Uniprot ID:
Q12676
Molecular weight:
47850.80078
Reactions
ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate → ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).
General function:
Involved in formate-tetrahydrofolate ligase activity
Specific function:
5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH
Gene Name:
MIS1
Uniprot ID:
P09440
Molecular weight:
106216.0
Reactions
5,10-methylenetetrahydrofolate + NADP(+) → 5,10-methenyltetrahydrofolate + NADPH.
5,10-methenyltetrahydrofolate + H(2)O → 10-formyltetrahydrofolate.
ATP + formate + tetrahydrofolate → ADP + phosphate + 10-formyltetrahydrofolate.
General function:
Involved in formate-tetrahydrofolate ligase activity
Specific function:
5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH
Gene Name:
ADE3
Uniprot ID:
P07245
Molecular weight:
102204.0
Reactions
5,10-methylenetetrahydrofolate + NADP(+) → 5,10-methenyltetrahydrofolate + NADPH.
5,10-methenyltetrahydrofolate + H(2)O → 10-formyltetrahydrofolate.
ATP + formate + tetrahydrofolate → ADP + phosphate + 10-formyltetrahydrofolate.
General function:
Involved in acid phosphatase activity
Specific function:
A phosphate monoester + H(2)O = an alcohol + phosphate
Gene Name:
PHO11
Uniprot ID:
P35842
Molecular weight:
52757.39844
Reactions
A phosphate monoester + H(2)O → an alcohol + phosphate.
General function:
Involved in acid phosphatase activity
Specific function:
Partially mediates extracellular nucleotide derived phosphate hydrolysis along with NPP1 and NPP2
Gene Name:
PHO5
Uniprot ID:
P00635
Molecular weight:
52858.10156
Reactions
A phosphate monoester + H(2)O → an alcohol + phosphate.
General function:
Involved in 3'(2'),5'-bisphosphate nucleotidase activity
Specific function:
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. Involved in salt tolerance. Confers resistance to lithium
Gene Name:
HAL2
Uniprot ID:
P32179
Molecular weight:
39148.89844
Reactions
Adenosine 3',5'-bisphosphate + H(2)O → adenosine 5'-phosphate + phosphate.
General function:
Involved in hydrolase activity
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P28273
Molecular weight:
140426.0
Reactions
ATP + 5-oxo-L-proline + 2 H(2)O → ADP + phosphate + L-glutamate.
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Gene Name:
SAM1
Uniprot ID:
P10659
Molecular weight:
41818.0
Reactions
ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine.
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
Catalyzes the rate-limiting reaction in the mitochondrial fatty acid synthesis (FAS) type II pathway. Responsible for the production of the mitochondrial malonyl-CoA, used for the biosynthesis of the cofactor lipoic acid. This protein carries three functions:biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase
Gene Name:
HFA1
Uniprot ID:
P32874
Molecular weight:
259161.0
Reactions
ATP + acetyl-CoA + HCO(3)(-) → ADP + phosphate + malonyl-CoA.
ATP + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].
General function:
Involved in catalytic activity
Specific function:
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Gene Name:
PYC1
Uniprot ID:
P11154
Molecular weight:
130098.0
Reactions
ATP + pyruvate + HCO(3)(-) → ADP + phosphate + oxaloacetate.
General function:
Involved in ATP binding
Specific function:
PI-SceI is an endonuclease that can cleave at a site present in a VMA1 allele that lacks the derived endonuclease segment of the open reading frame; cleavage at this site only occurs during meiosis and initiates "homing", a genetic event that converts a VMA1 allele lacking VDE into one that contains it
Gene Name:
TFP1
Uniprot ID:
P17255
Molecular weight:
118636.0
Reactions
ATP + H(2)O + H(+)(In) → ADP + phosphate + H(+)(Out).
General function:
Involved in ATP binding
Specific function:
ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2)
Gene Name:
MVD1
Uniprot ID:
P32377
Molecular weight:
44115.5
Reactions
ATP + (R)-5-diphosphomevalonate → ADP + phosphate + isopentenyl diphosphate + CO(2).
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
Carries out three functions:biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase
Gene Name:
FAS3
Uniprot ID:
Q00955
Molecular weight:
250351.0
Reactions
ATP + acetyl-CoA + HCO(3)(-) → ADP + phosphate + malonyl-CoA.
ATP + biotin-[carboxyl-carrier-protein] + CO(2) → ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].
General function:
Involved in binding
Specific function:
Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate. STT4 functions in PKC1 protein kinase pathway
Gene Name:
STT4
Uniprot ID:
P37297
Molecular weight:
214605.0
Reactions
ATP + 1-phosphatidyl-1D-myo-inositol → ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
General function:
Involved in nucleotide binding
Specific function:
The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses
Gene Name:
PMA1
Uniprot ID:
P05030
Molecular weight:
99618.39844
Reactions
ATP + H(2)O + H(+)(In) → ADP + phosphate + H(+)(Out).
General function:
Involved in DNA binding
Specific function:
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxin TSA1. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and as thioltransferase
Gene Name:
SRX1
Uniprot ID:
P36077
Molecular weight:
13853.90039
Reactions
Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH → peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.
General function:
Involved in ATP adenylyltransferase activity
Specific function:
Sustains the catabolism of Np-4-N' nucleotides, rather than their synthesis
Gene Name:
APA2
Uniprot ID:
P22108
Molecular weight:
36840.5
Reactions
ADP + ATP → phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate.
General function:
Involved in catalytic activity
Specific function:
A phosphate monoester + H(2)O = an alcohol + phosphate
Gene Name:
PHO8
Uniprot ID:
P11491
Molecular weight:
63003.60156
Reactions
A phosphate monoester + H(2)O → an alcohol + phosphate.
(2E,6E)-farnesyl diphosphate + H(2)O → (2E,6E)-farnesol + diphosphate.
beta-D-fructose 2,6-bisphosphate + H2O → beta-D-fructofuranose 2-phosphate + phosphate
General function:
Involved in tetrahydrofolylpolyglutamate synthase activity
Specific function:
Conversion of folates to polyglutamate derivatives
Gene Name:
RMA1
Uniprot ID:
P36001
Molecular weight:
48142.89844
Reactions
ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate → ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).
General function:
Involved in nucleotide binding
Specific function:
The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses
Gene Name:
PMA2
Uniprot ID:
P19657
Molecular weight:
102171.0
Reactions
ATP + H(2)O + H(+)(In) → ADP + phosphate + H(+)(Out).
General function:
Involved in ATP binding
Specific function:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits
Gene Name:
ATP2
Uniprot ID:
P00830
Molecular weight:
54793.30078
Reactions
ATP + H(2)O + H(+)(In) → ADP + phosphate + H(+)(Out).
General function:
Involved in catalytic activity
Specific function:
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Gene Name:
PYC2
Uniprot ID:
P32327
Molecular weight:
130166.0
Reactions
ATP + pyruvate + HCO(3)(-) → ADP + phosphate + oxaloacetate.
General function:
Involved in ATP binding
Specific function:
Utilizes 5-formyltetrahydrofolate (folinic acid) as substrate in an alternative way of folate biosynthesis
Gene Name:
FAU1
Uniprot ID:
P40099
Molecular weight:
24058.5
Reactions
ATP + 5-formyltetrahydrofolate → ADP + phosphate + 5,10-methenyltetrahydrofolate.
General function:
Involved in phosphatidylinositol phosphate kinase activity
Specific function:
Catalyzes the phosphorylation of phosphatidylinositol-4- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol-4,5-biphosphate. Acts downstream of STT4, but in a pathway that does not involve PKC1. May be involved in the organization of the actin cytoskeleton
Gene Name:
MSS4
Uniprot ID:
P38994
Molecular weight:
89319.60156
Reactions
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate → ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
General function:
Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Specific function:
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
Gene Name:
TDH1
Uniprot ID:
P00360
Molecular weight:
35749.60156
Reactions
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) → 3-phospho-D-glyceroyl phosphate + NADH.
General function:
Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Specific function:
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
Gene Name:
TDH2
Uniprot ID:
P00358
Molecular weight:
35846.60156
Reactions
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) → 3-phospho-D-glyceroyl phosphate + NADH.
General function:
Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Specific function:
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
Gene Name:
TDH3
Uniprot ID:
P00359
Molecular weight:
35746.39844
Reactions
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) → 3-phospho-D-glyceroyl phosphate + NADH.
General function:
Involved in catalytic activity
Specific function:
O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate
Gene Name:
SER2
Uniprot ID:
P42941
Molecular weight:
34207.0
Reactions
O-phospho-L(or D)-serine + H(2)O → L(or D)-serine + phosphate.
General function:
Involved in histidinol-phosphatase activity
Specific function:
L-histidinol phosphate + H(2)O = L-histidinol + phosphate
Gene Name:
HIS2
Uniprot ID:
P38635
Molecular weight:
38581.5
Reactions
L-histidinol phosphate + H(2)O → L-histidinol + phosphate.
General function:
Involved in protein tyrosine/serine/threonine phosphatase activity
Specific function:
May act as a phosphoinositide 3-phosphatase by regulating PtdIns(3,4,5)P3 levels
Gene Name:
TEP1
Uniprot ID:
P53916
Molecular weight:
50151.5
Reactions
Phosphatidylinositol 3,4,5-trisphosphate + H(2)O → phosphatidylinositol 4,5-bisphosphate + phosphate.
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate
Gene Name:
PRO2
Uniprot ID:
P54885
Molecular weight:
49740.0
Reactions
L-glutamate 5-semialdehyde + phosphate + NADP(+) → L-glutamyl 5-phosphate + NADPH.
General function:
Involved in chorismate synthase activity
Specific function:
5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate
Gene Name:
ARO2
Uniprot ID:
P28777
Molecular weight:
40838.0
Reactions
5-O-(1-carboxyvinyl)-3-phosphoshikimate → chorismate + phosphate.
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and involved in the inositol cycle of calcium signaling
Gene Name:
INM2
Uniprot ID:
Q05533
Molecular weight:
32092.40039
Reactions
Myo-inositol phosphate + H(2)O → myo-inositol + phosphate.
General function:
Involved in catalytic activity
Specific function:
Seems to be implicated in the regulation of the expression of the ADH2 gene
Gene Name:
MEU1
Uniprot ID:
Q07938
Molecular weight:
37856.30078
Reactions
S-methyl-5'-thioadenosine + phosphate → adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
General function:
Involved in nicotinate phosphoribosyltransferase activity
Specific function:
Essential for growth under anaerobic conditions
Gene Name:
NPT1
Uniprot ID:
P39683
Molecular weight:
49018.19922
Reactions
Nicotinate D-ribonucleotide + diphosphate → nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
General function:
Involved in catalytic activity
Specific function:
Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process. Can function independently of the complex
Gene Name:
TPS1
Uniprot ID:
Q00764
Molecular weight:
56147.5
Reactions
UDP-glucose + D-glucose 6-phosphate → UDP + alpha,alpha-trehalose 6-phosphate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Gene Name:
THR4
Uniprot ID:
P16120
Molecular weight:
57473.69922
Reactions
O-phospho-L-homoserine + H(2)O → L-threonine + phosphate.
General function:
Involved in magnesium ion binding
Specific function:
Involved in energy production. Its activity is stimulated by uncouplers of ATP synthesis
Gene Name:
PPA2
Uniprot ID:
P28239
Molecular weight:
35572.39844
Reactions
Diphosphate + H(2)O → 2 phosphate.
General function:
Involved in magnesium ion binding
Specific function:
Diphosphate + H(2)O = 2 phosphate
Gene Name:
IPP1
Uniprot ID:
P00817
Molecular weight:
32299.30078
Reactions
Diphosphate + H(2)O → 2 phosphate.
General function:
Involved in acid phosphatase activity
Specific function:
A phosphate monoester + H(2)O = an alcohol + phosphate
Gene Name:
PHO3
Uniprot ID:
P24031
Molecular weight:
52776.10156
Reactions
A phosphate monoester + H(2)O → an alcohol + phosphate.
General function:
Involved in catalytic activity
Specific function:
PHO13 is dispensable for vegetative growth and sporulation
Gene Name:
PHO13
Uniprot ID:
P19881
Molecular weight:
34624.30078
Reactions
4-nitrophenyl phosphate + H(2)O → 4-nitrophenol + phosphate.
General function:
Involved in hydrolase activity
Specific function:
After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol
Gene Name:
GDA1
Uniprot ID:
P32621
Molecular weight:
56821.0
Reactions
GDP + H(2)O → GMP + phosphate.
General function:
Involved in phosphorylase activity
Specific function:
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties
Gene Name:
GPH1
Uniprot ID:
P06738
Molecular weight:
103274.0
Reactions
(1,4-alpha-D-glucosyl)(n) + phosphate → (1,4-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in clathrin-mediated protein sorting at the TGN
Gene Name:
INP53
Uniprot ID:
Q12271
Molecular weight:
124576.0
Reactions
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O → 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
D-myo-inositol 1,4,5-trisphosphate + H2O → D-myo-inositol 1,4-bisphosphate + phosphate
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O → D-myo-inositol 1,3,4-trisphosphate + phosphate
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Specifically functions within the early endocytic pathway and actin organization
Gene Name:
INP52
Uniprot ID:
P50942
Molecular weight:
133330.0
Reactions
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O → 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
D-myo-inositol 1,4,5-trisphosphate + H2O → D-myo-inositol 1,4-bisphosphate + phosphate
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O → D-myo-inositol 1,3,4-trisphosphate + phosphate
General function:
Involved in catalytic activity
Specific function:
Active on 2-DOG-6P, also very active on fructose-1P
Gene Name:
DOG1
Uniprot ID:
P38774
Molecular weight:
27099.59961
Reactions
2-deoxy-D-glucose 6-phosphate + H(2)O → 2-deoxy-D-glucose + phosphate.
General function:
Involved in catalytic activity
Specific function:
Active on 2-DOG-6P, not very active on fructose-1p
Gene Name:
DOG2
Uniprot ID:
P38773
Molecular weight:
27164.80078
Reactions
2-deoxy-D-glucose 6-phosphate + H(2)O → 2-deoxy-D-glucose + phosphate.
General function:
Involved in catalytic activity
Specific function:
Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex
Gene Name:
TPS3
Uniprot ID:
P38426
Molecular weight:
118834.0
Reactions
General function:
Involved in catalytic activity
Specific function:
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Gene Name:
Not Available
Uniprot ID:
Q12040
Molecular weight:
26176.5
Reactions
2-phospho-D-glycerate → 3-phospho-D-glycerate.
General function:
Involved in catalytic activity
Specific function:
Could be non-functional
Gene Name:
GPM2
Uniprot ID:
Q12008
Molecular weight:
36072.80078
Reactions
2-phospho-D-glycerate → 3-phospho-D-glycerate.
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Regulates the phosphatidylinositol (4,5)-diphosphate levels on the cytoplasmic surface of the endoplasmic reticulum and thereby regulates secretion
Gene Name:
INP54
Uniprot ID:
Q08227
Molecular weight:
43798.69922
Reactions
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O → 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
General function:
Involved in phosphoric ester hydrolase activity
Specific function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Major enzyme required for hyperosmotic shock- induced turnover of PtdIns(3,5)P2 and requires VAC14 for this function. In vivo, mediates turnover of PtdIns(3,5)P2 at the vacuole membrane necessary for vacuolar size control. In vitro, catalyzes the removal of phosphate from the fifth hydroxyl of the myo-inositol ring of phosphatidylinositol-3,5-bisphosphate
Gene Name:
FIG4
Uniprot ID:
P42837
Molecular weight:
101745.0
Reactions
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H(2)O → 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in endocytosis and acts as a negative regulator of the Slm pathway which modulates polarized actin assembly and growth
Gene Name:
INP51
Uniprot ID:
P40559
Molecular weight:
108429.0
Reactions
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O → 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the dephosphorylation of diacylglycerol phosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with DPP1, regulates intracellular DGPP and PA levels which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) as a substrate. Substrate preference is PA > DGPP > LPA
Gene Name:
LPP1
Uniprot ID:
Q04396
Molecular weight:
31585.90039
Reactions
A 1,2-diacylglycerol 3-phosphate + H(2)O → a 1,2-diacyl-sn-glycerol + phosphate.
Diacylglycerol pyrophosphate + H(2)O → phosphatidate + phosphate.
General function:
Involved in catalytic activity
Specific function:
Catalyzes the dephosphorylation of diacylglycerol phosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Together with LPP1, regulates intracellular DGPP and PA levels which are phospholipid molecules believed to play a signaling role in stress response. Can also use lysophosphatidic acid (LPA) as a substrate. Substrate preference is DGPP > LPA > PA
Gene Name:
DPP1
Uniprot ID:
Q05521
Molecular weight:
33513.60156
Reactions
A 1,2-diacylglycerol 3-phosphate + H(2)O → a 1,2-diacyl-sn-glycerol + phosphate.
Diacylglycerol pyrophosphate + H(2)O → phosphatidate + phosphate.
General function:
Involved in phosphatidylglycerophosphatase activity
Specific function:
Phosphatidylglycerophosphatase involved in the biosynthesis of cardiolipin (CL), a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes and which has important functions for cellular energy metabolism, mitochondrial dynamics and the initiation of apoptotic pathways. Required for the stability of respiratory chain supercomplexes and for growth at elevated temperature, in presence of ethidium bromide or in absence of prohibitins
Gene Name:
GEP4
Uniprot ID:
P38812
Molecular weight:
20944.90039
Reactions
Phosphatidylglycerophosphate + H(2)O → phosphatidylglycerol + phosphate.
General function:
Involved in protein tyrosine phosphatase activity
Specific function:
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates
Gene Name:
LTP1
Uniprot ID:
P40347
Molecular weight:
18675.09961
Reactions
Protein tyrosine phosphate + H(2)O → protein tyrosine + phosphate.
A phosphate monoester + H(2)O → an alcohol + phosphate.
General function:
Involved in endopolyphosphatase activity
Specific function:
Catalyzes the hydrolysis of inorganic polyphosphate (poly P) chains of many hundreds of phosphate residues into shorter lengths. The limited digestion products are 1 and 3 P(i) residues
Gene Name:
PPN1
Uniprot ID:
Q04119
Molecular weight:
78343.70313
Reactions
Polyphosphate + n H(2)O → (n+1) oligophosphate.
(Polyphosphate)(n) + H(2)O → (polyphosphate)(n-1) + phosphate.
General function:
Involved in acid phosphatase activity
Specific function:
A phosphate monoester + H(2)O = an alcohol + phosphate
Gene Name:
DIA3
Uniprot ID:
P52290
Molecular weight:
53075.89844
Reactions
A phosphate monoester + H(2)O → an alcohol + phosphate.
General function:
Involved in acid phosphatase activity
Specific function:
A phosphate monoester + H(2)O = an alcohol + phosphate
Gene Name:
PHO12
Uniprot ID:
P38693
Molecular weight:
52699.30078
Reactions
A phosphate monoester + H(2)O → an alcohol + phosphate.
General function:
Involved in pyrophosphatase activity
Specific function:
Degradation of inorganic polyphosphates
Gene Name:
PPX1
Uniprot ID:
P38698
Molecular weight:
45051.0
Reactions
(Polyphosphate)(n) + H(2)O → (polyphosphate)(n-1) + phosphate.
General function:
Coenzyme transport and metabolism
Specific function:
Conversion of folates to polyglutamate derivatives
Gene Name:
MET7
Uniprot ID:
Q08645
Molecular weight:
62150.89844
Reactions
ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate → ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1).
General function:
Coenzyme transport and metabolism
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Gene Name:
SAM2
Uniprot ID:
P19358
Molecular weight:
42255.5
Reactions
ATP + L-methionine + H(2)O → phosphate + diphosphate + S-adenosyl-L-methionine.
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q12486
Molecular weight:
24839.80078
Reactions
2-Phosphoglycolate + H2O → glycolate + phosphate
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q04223
Molecular weight:
35278.10156
Reactions
2-Phosphoglycolate + H2O → glycolate + phosphate
General function:
Involved in inositol or phosphatidylinositol phosphatase activity
Specific function:
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides
Gene Name:
INM1
Uniprot ID:
P38710
Molecular weight:
32823.0
Reactions
Myo-inositol phosphate + H(2)O → myo-inositol + phosphate.
General function:
tRNA wobble uridine modification
Specific function:
Involved in the dephosphorylation of the large subunit of RNA polymerase II. Is required in late G1 for normal G1 cyclin expression, bud initiation and expression of certain genes that are periodically expressed during late G1. Associates with the SAP proteins in a cell cycle-dependent manner.
Gene Name:
SIT4
Uniprot ID:
P20604
Molecular weight:
35537.32
Reactions
General function:
vacuole fusion, non-autophagic
Specific function:
Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol. Required for de novo lipid synthesis and formation of lipid droplets. Controles transcription of phospholipid biosynthetic genes and nuclear structure by regulating the amount of membrane present at the nuclear envelope. Involved in plasmid maintenance, in respiration and in cell proliferation.
Gene Name:
PAH1
Uniprot ID:
P32567
Molecular weight:
95029.985
Reactions
General function:
translational initiation
Specific function:
Phosphatidylinositol 3-kinase homolog, component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. TORC1 controls many of these processes via TIP41-TAP42-mediated inhibition of the type 2A-related phosphatases PP2A and SIT4 (PubMed:10198052, PubMed:10329624, PubMed:10604478, PubMed:10995454, PubMed:11741537, PubMed:15620355, PubMed:7606777, PubMed:8741837, PubMed:9539725, PubMed:9843498). In nutrient rich conditions, responsible for the phosphorylation of AGC S6 kinase (S6K) YPK3, activating YPK3 kinase activity and promoting phosphorylation of ribosomal protein S6 (PubMed:25767889). Phosphorylates kinase SCH9 at 6 amino acids in the C-terminus, activating SCH9 kinase activity to properly regulate ribosome biogenesis, translation initiation, and entry into stationary phase (PubMed:17560372).
Gene Name:
TOR1
Uniprot ID:
P35169
Molecular weight:
281136.755
Reactions
General function:
ribosome biogenesis
Specific function:
Sedoheptulose 1,7-bisphosphatase involved in riboneogenesis. Dephosphorylates sedoheptulose 1,7-bisphosphate (SBP), which is converted via the non-oxidative pentose phosphate pathway to ribose-5-phosphate. Has a fructose 1,6-bisphosphatase activity in vitro, but this is probably not biologically relevant, since deletion does not affect fructose 1,6-biphosphate (FBP) levels.
Gene Name:
SHB17
Uniprot ID:
P36136
Molecular weight:
31021.71
Reactions

Transporters

General function:
Involved in nucleotide binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the sodium or lithium ions to allow salt tolerance. Is negatively modulated by SIS2/HAL3
Gene Name:
ENA1
Uniprot ID:
P13587
Molecular weight:
120356.0
Reactions
ATP + H(2)O + Na(+)(In) → ADP + phosphate + Na(+)(Out).
General function:
Involved in nucleotide binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithium ions to allow salt tolerance
Gene Name:
ENA5
Uniprot ID:
Q12691
Molecular weight:
120295.0
Reactions
ATP + H(2)O + Na(+)(In) → ADP + phosphate + Na(+)(Out).
General function:
Involved in nucleotide binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of sodium or lithiums ions to allow salt tolerance
Gene Name:
ENA2
Uniprot ID:
Q01896
Molecular weight:
120316.0
Reactions
ATP + H(2)O + Na(+)(In) → ADP + phosphate + Na(+)(Out).
General function:
Involved in ATP binding
Specific function:
STE6 is required in yeast MATA cells for production of A-factor pheromone. STE6 is involved in the transport of the farnesyl-derivation of the A-factor pheromone
Gene Name:
STE6
Uniprot ID:
P12866
Molecular weight:
144764.0
Reactions
ATP + H(2)O + alpha-factor(In) → ADP + phosphate + alpha-factor(Out).
General function:
Involved in nucleotide binding
Specific function:
Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone ATX1 and incorporates it into trans-Golgi vesicles
Gene Name:
CCC2
Uniprot ID:
P38995
Molecular weight:
109828.0
Reactions
ATP + H(2)O + Cu(2+)(In) → ADP + phosphate + Cu(2+)(Out).
General function:
Involved in nucleotide binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Has a role in the secretory pathway
Gene Name:
PMR1
Uniprot ID:
P13586
Molecular weight:
104570.0
Reactions
ATP + H(2)O + Ca(2+)(Cis) → ADP + phosphate + Ca(2+)(Trans).
General function:
Involved in nucleotide binding
Specific function:
ATP + H(2)O = ADP + phosphate
Gene Name:
SPF1
Uniprot ID:
P39986
Molecular weight:
135267.0
Reactions
ATP + H(2)O → ADP + phosphate.
General function:
Involved in nucleotide binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium
Gene Name:
PMC1
Uniprot ID:
P38929
Molecular weight:
130860.0
Reactions
ATP + H(2)O + Ca(2+)(Cis) → ADP + phosphate + Ca(2+)(Trans).
General function:
Involved in nucleotide binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential)
Gene Name:
DNF3
Uniprot ID:
Q12674
Molecular weight:
188318.0
Reactions
ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out).
General function:
Involved in nucleotide binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. Required for protein transport from Golgi to vacuoles
Gene Name:
DNF2
Uniprot ID:
Q12675
Molecular weight:
182617.0
Reactions
ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out).
General function:
Involved in nucleotide binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Seems to be involved in ribosome assembly
Gene Name:
DRS2
Uniprot ID:
P39524
Molecular weight:
153843.0
Reactions
ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out).
General function:
Involved in nucleotide binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential)
Gene Name:
DNF1
Uniprot ID:
P32660
Molecular weight:
177796.0
Reactions
ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out).
General function:
Involved in nucleotide binding
Specific function:
Probably involved in copper transport and in the regulation of cellular copper level
Gene Name:
PCA1
Uniprot ID:
P38360
Molecular weight:
131838.0
Reactions
ATP + H(2)O + Cu(2+)(In) → ADP + phosphate + Cu(2+)(Out).
ATP + H2O + Cd2+/in → ADP + phosphate + Cd2+/out
General function:
Involved in nucleotide binding
Specific function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes
Gene Name:
NEO1
Uniprot ID:
P40527
Molecular weight:
130217.0
Reactions
ATP + H(2)O + phospholipid(In) → ADP + phosphate + phospholipid(Out).
General function:
Involved in nucleotide binding
Specific function:
ATP + H(2)O = ADP + phosphate
Gene Name:
Not Available
Uniprot ID:
Q12697
Molecular weight:
166748.0
Reactions
ATP + H(2)O → ADP + phosphate.