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Identification
NameGlutathione peroxidase 1
SynonymsNot Available
Gene NameGPX1
Enzyme Class
Biological Properties
General FunctionInvolved in glutathione peroxidase activity
Specific FunctionMay constitute a glutathione peroxidase-like protective system against oxidative stresses
Cellular LocationNot Available
SMPDB Pathways
Glutathione metabolismPW002395 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Arachidonic acid metabolismec00590 Map00590
Glutathione metabolismec00480 Map00480
SMPDB ReactionsNot Available
KEGG Reactions
Hydrogen peroxide + Glutathionewater + Oxidized glutathione
Metabolites
YMDB IDNameView
YMDB00057Oxidized glutathioneShow
YMDB00160GlutathioneShow
YMDB00693glutathione disulfideShow
YMDB00888Hydrogen peroxideShow
YMDB00890waterShow
GO Classification
Component
Not Available
Function
antioxidant activity
peroxidase activity
glutathione peroxidase activity
Process
response to stress
response to oxidative stress
metabolic process
oxidation reduction
response to stimulus
Gene Properties
Chromosome Locationchromosome 11
LocusYKL026C
Gene Sequence>504 bp ATGCAAGAATTTTATTCTTTTTCACCAATAGATGAAAACGGAAATCCATTCCCCTTCAAC TCCCTGCGTAACAAAGTGGTTTTGATAGTCAATGTAGCATCTCATTGTGCGTTCACACCT CAATACAAGGAATTAGAGTACTTGTACGAAAAATACAAATCACATGGTCTAGTGATTGTG GCCTTTCCCTGTGGTCAATTCGGAAATCAAGAGTTCGAGAAGGATAAAGAGATTAATAAG TTCTGTCAAGATAAATATGGTGTAACCTTCCCTATTCTACATAAGATCCGTTGCAACGGG CAAAAGCAAGATCCCGTCTACAAGTTCTTAAAGAATTCAGTAAGCGGGAAGTCTGGAATA AAAATGATAAAATGGAATTTTGAAAAGTTTGTGGTAGACCGAAATGGGAAGGTGGTTAAA AGGTTTTCATGCATGACTAGGCCACTAGAGCTTTGTCCAATAATCGAAGAATTACTGAAT CAACCACCAGAAGAACAGATTTAA
Protein Properties
Pfam Domain Function
Protein Residues167
Protein Molecular Weight19484.5
Protein Theoretical pI8.57
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Glutathione peroxidase 1 MQEFYSFSPIDENGNPFPFNSLRNKVVLIVNVASHCAFTPQYKELEYLYEKYKSHGLVIV AFPCGQFGNQEFEKDKEINKFCQDKYGVTFPILHKIRCNGQKQDPVYKFLKNSVSGKSGI KMIKWNFEKFVVDRNGKVVKRFSCMTRPLELCPIIEELLNQPPEEQI
References
External Links
ResourceLink
Saccharomyces Genome Database GPX1
Uniprot IDP36014
Uniprot NameGPX1_YEAST
GenBank Gene IDAY557895
Genebank Protein ID45269681
General Reference
  • Dujon, B., Alexandraki, D., Andre, B., Ansorge, W., Baladron, V., Ballesta, J. P., Banrevi, A., Bolle, P. A., Bolotin-Fukuhara, M., Bossier, P., et, a. l. .. (1994). "Complete DNA sequence of yeast chromosome XI." Nature 369:371-378.8196765
  • Avery, A. M., Avery, S. V. (2001). "Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases." J Biol Chem 276:33730-33735.11445588
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287