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Glutathione metabolism

Source	ID	Pathway
PathWhiz	PW002395
KEGG	00480

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00016	Glycine 56-40-6	2-aminoacetic acid	C₂H₅NO₂ 75.0666
YMDB00046	L-Cysteine 52-90-4	(2R)-2-amino-3-sulfanylpropanoic acid	C₃H₇NO₂S 121.158
YMDB00057	Oxidized glutathione 27025-41-8	2-amino-4-[(2-{[2-(4-amino-4-carboxybutanamido)-2-[(carboxymethyl)carbamoyl]ethyl]disulfanyl}-1-[(carboxymethyl)carbamoyl]ethyl)carbamoyl]butanoic acid	C₂₀H₃₂N₆O₁₂S₂ 612.631
YMDB00107	Pyroglutamic acid 98-79-3	(2S)-5-oxopyrrolidine-2-carboxylic acid	C₅H₇NO₃ 129.114
YMDB00109	Adenosine triphosphate 56-65-5	({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid	C₁₀H₁₆N₅O₁₃P₃ 507.181
YMDB00132	Putrescine 110-60-1	butane-1,4-diamine	C₄H₁₂N₂ 88.1515
YMDB00160	Glutathione 70-18-8	(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid	C₁₀H₁₇N₃O₆S 307.323
YMDB00231	Spermine 71-44-3	(3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine	C₁₀H₂₆N₄ 202.3402
YMDB00232	Spermidine 124-20-9	(4-aminobutyl)(3-aminopropyl)amine	C₇H₁₉N₃ 145.2459
YMDB00252	Gamma-Glutamylcysteine 636-58-8	(2S)-2-amino-4-{[(1R)-1-carboxy-2-sulfanylethyl]carbamoyl}butanoic acid	C₈H₁₄N₂O₅S 250.272
YMDB00271	L-Glutamic acid 56-86-0	(2S)-2-aminopentanedioic acid	C₅H₉NO₄ 147.1293
YMDB00312	Acetyl-CoA 72-89-9	{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₃H₃₈N₇O₁₇P₃S 809.571
YMDB00426	NADPH 53-57-6	{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₁H₃₀N₇O₁₇P₃ 745.4209
YMDB00427	NADP 53-59-8	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₉N₇O₁₇P₃ 744.4129
YMDB00690	L-cysteinylglycine 70-18-8	2-[(2R)-2-amino-3-sulfanylpropanamido]acetic acid	C₅H₁₀N₂O₃S 178.21
YMDB00691	L-gamma-Glutamyl-L-alanine 5875-41-2	(2S)-2-amino-4-{[(1S)-1-carboxyethyl]carbamoyl}butanoic acid	C₈H₁₄N₂O₅ 218.2072
YMDB00693	glutathione disulfide 27025-41-8		C₂₀H₃₂N₆O₁₂S₂ 612.631
YMDB00862	hydron 12408-02-5	hydron	H 1.00794
YMDB00890	water 7732-18-5	water	H₂O 18.0153
YMDB00907	phosphate 14265-44-2	phosphoric acid	O₄P 94.9714
YMDB00914	ADP 58-64-0	[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid	C₁₀H₁₅N₅O₁₀P₂ 427.2011

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P38143	GPX2 YBR244W	Glutathione peroxidase 2	Enzyme	Oxidized glutathione Glutathione glutathione disulfide Hydrogen peroxide water
Q08220	GSH2 YOL049W	Glutathione synthetase	Enzyme	Glycine Adenosine triphosphate Glutathione Gamma-Glutamylcysteine hydron phosphate ADP
P53982	IDP3 YNL009W	Isocitrate dehydrogenase [NADP]	Enzyme	Isocitric acid Oxoglutaric acid Oxalosuccinic acid NADPH NADP hydron Carbon dioxide
P21954	IDP1 YDL066W	Isocitrate dehydrogenase [NADP], mitochondrial	Enzyme	Isocitric acid Oxoglutaric acid Oxalosuccinic acid NADPH NADP hydron Carbon dioxide
P41939	IDP2 YLR174W	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	Isocitric acid Oxoglutaric acid Oxalosuccinic acid NADPH NADP hydron Carbon dioxide
P32477	GSH1 YJL101C	Glutamate--cysteine ligase	Enzyme	L-Cysteine Adenosine triphosphate Gamma-Glutamylcysteine L-Glutamic acid hydron phosphate ADP
P41921	GLR1 YPL091W	Glutathione reductase	Enzyme	Coenzyme A Oxidized glutathione NAD NADH Oxoglutaric acid Glutathione Pyruvic acid Acetyl-CoA Thiamine pyrophosphate NADPH NADP Succinyl-CoA glutathione disulfide hydron Carbon dioxide 2-(a-Hydroxyethyl)thiamine diphosphate
P36014	GPX1 YKL026C	Glutathione peroxidase 1	Enzyme	Oxidized glutathione Glutathione glutathione disulfide Hydrogen peroxide water
P09938	RNR2 YJL026W	Ribonucleoside-diphosphate reductase small chain 1	Enzyme	CDP Guanosine diphosphate Uridine 5'-diphosphate dUDP water dGDP dADP ADP dCDP
P21524	RNR1 YER070W	Ribonucleoside-diphosphate reductase large chain 1	Enzyme	CDP Guanosine diphosphate Uridine 5'-diphosphate dUDP water dGDP dADP ADP dCDP
Q12455	SPE4 YLR146C	Spermine synthase	Enzyme	S-Adenosylmethioninamine 5'-Methylthioadenosine Spermine Spermidine hydron
Q12074	SPE3 YPR069C	Spermidine synthase	Enzyme	S-Adenosylmethioninamine Putrescine 5'-Methylthioadenosine Spermidine hydron
P08432	SPE1 YKL184W	Ornithine decarboxylase	Enzyme	Putrescine Ornithine hydron Carbon dioxide
Q05902	ECM38 YLR299W	Gamma-glutamyltransferase	Enzyme	L-Cysteine L-Alanine Glutathione Gamma-Glutamylcysteine L-Glutamic acid L-cysteinylglycine L-gamma-Glutamyl-L-alanine water
P36156	ECM4 YKR076W	Glutathione S-transferase omega-like 2	Enzyme	Glutathione
Q04806	GTO3 YMR251W	Glutathione S-transferase omega-like 3	Enzyme	Glutathione
Q12390	GTT2 YLL060C	Glutathione S-transferase 2	Enzyme	Glutathione
P48239	GTO1 YGR154C	Glutathione S-transferase omega-like 1	Enzyme	Glutathione
P40581	HYR1 YIR037W	Peroxiredoxin HYR1	Enzyme	Oxidized glutathione Glutathione glutathione disulfide Hydrogen peroxide water
P40582	GTT1 YIR038C	Glutathione S-transferase 1	Enzyme	Glutathione
P38720	GND1 YHR183W	6-phosphogluconate dehydrogenase, decarboxylating 1	Enzyme	6-Phosphogluconic acid NADPH NADP Carbon dioxide D-ribulose 5-phosphate
P53319	GND2 YGR256W	6-phosphogluconate dehydrogenase, decarboxylating 2	Enzyme	6-Phosphogluconic acid NADPH NADP Carbon dioxide D-ribulose 5-phosphate
P49723	RNR4 YGR180C	Ribonucleoside-diphosphate reductase small chain 2	Enzyme	Guanosine diphosphate Uridine 5'-diphosphate dUDP water
P11412	ZWF1 YNL241C	Glucose-6-phosphate 1-dehydrogenase	Enzyme	6-Phosphonoglucono-D-lactone NADPH NADP aldehydo-D-glucose 6-phosphate hydron Glucose 6-phosphate
P21672	RNR3	Ribonucleoside-diphosphate reductase large chain 2	Enzyme	Guanosine diphosphate water dADP ADP
P43616	DUG1	Cys-Gly metallodipeptidase DUG1		Glycine L-Cysteine L-cysteinylglycine water