{"ymdb_id":"YMDB00130","created_at":"2011-05-29T15:59:43.000Z","updated_at":"2016-09-08T18:35:04.000Z","name":"S-Adenosylmethioninamine","cas":"22365-13-5","state":"Solid","melting_point":"","description":"S-Adenosylmethioninamine is the product of the enzyme adenosylmethionine decarboxylase [EC 4.1.1.50] in the methionine metabolism pathway. [KEGG]","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":"Pegg, Anthony E.  Assay of aminopropyltransferases.    Methods in Enzymology  (1983),  94(Polyamines),  260-5.","chebi_id":"15625","hmdb_id":"HMDB00988","kegg_id":"C01137","pubchem_id":"1078","cs_id":"25050861","foodb_id":null,"wikipedia_link":"S-Adenosylmethioninamine","biocyc_id":"S-ADENOSYLMETHIONINAMINE","iupac":"{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(3-aminopropyl)methylsulfanium","traditional_iupac":"decarboxylated sam","logp":"-2.750104969875945","pka":"13.949691543979075","alogps_solubility":"1.27e+00 g/l","alogps_logp":"0.28","alogps_logs":"-2.49","acceptor_count":"8","donor_count":"4","rotatable_bond_count":"6","polar_surface_area":"145.33","refractivity":"90.40499999999997","polarizability":"36.96634847619492","formal_charge":"1","physiological_charge":"2","pka_strongest_basic":"10.091308480422201","pka_strongest_acidic":"12.445729428479243","bioavailability":"1","number_of_rings":"3","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["(5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt","dAdoMet","decarboxylated AdoMet","decarboxylated S-adenosylmethionine","decarboxylated SAM","S-Adenosyl-L-methioninamine","S-adenosylmethioninamine"],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":18625006,"citation":"Pirkov, I., Norbeck, J., Gustafsson, L., Albers, E. (2008). \"A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.\" FEBS J 275:4111-4120."}],"proteins":[{"created_at":"2011-05-27T02:18:28.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Spermine synthase","uniprot_id":"Q12455","uniprot_name":"SPSY_YEAST","enzyme":true,"transporter":false,"gene_name":"SPE4","num_residues":300,"molecular_weight":"34090.5","theoretical_pi":"4.77","general_function":"Involved in catalytic activity","specific_function":"S-adenosylmethioninamine + spermidine = 5'- methylthioadenosine + spermine","reactions":[{"id":1971,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2669,"direction":"\u003e","locations":null,"altext":"S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.","export":false,"pw_reaction_id":null,"source":null},{"id":3762,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006286","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AF067970","genbank_protein_id":"3201943","gene_card_id":"SPE4","chromosome_location":"chromosome 12","locus":"YLR146C","synonyms":["SPMSY","Spermidine aminopropyltransferase"],"enzyme_classes":["2.5.1.22"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Spermine_synth","identifier":"PF01564"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGGTTAATAATTCACAGCATCCTTACATCAAAGATGGATGGTTTAGAGAGATTAATGATAAAAGTTTTCCGGGCCAGGCCTTTACTATGACCGTGGACTCAATACTTTATGAAGCCCGCAGTGAATTTCAGGACATCTTAATCTTCCGTAACAAGGTATACGGTACTGTTTTGGTCCTCGATGGTATTGTCCAATGTACGGAATTTGATGAGTTTGCCTATCAAGAGATGATCACCCACATTGCCATGTTTGCGCATTCTAATCCCAAGCGTGTACTTATCATTGGCGGTGGGGACGGAGGTGTCTTAAGGGAAGTAGCCAAGCACAGCTGTGTAGAAGATATCACTATGGTAGAAATTGACTCATCAGTGATCGAATTATCCCGTAAGTTCTTGCCCACATTGAGTAATGGTGCTTTCGATGACGAAAGGTTGGACTTGAAACTTTGCGATGGCTTCAAGTTCTTACAAGATATAGGTGCTTCCGACGTCCATAAGAAATTTGACGTCATTATTACAGATAGTTCTGATCCTGAAGGTCCAGCTGAAGCGTTTTTTCAAGAGAGGTATTTCGAACTATTGAAAGATGCTTTAAATCCTAATGGCGTTGTTATTATGCAAAGCTCTGAAAATTTTTGGTTAAATTTAAAATACTTACATGATTTGAAAAATACAGCCAAAAAGGTATTTCCTAATACAGAATATTGCTATACCATGGTTCCAACCTATACATCTGGCCAATTAGGTTTAATTGTTTGCAGTAATAACGCCAATATACCGTTGAACATTCCGCAAAGAAAGATATCTGAGCAAGAACAAGGGAAGCTGAAGTACTATAATCCTCAAATACATTCTAGTGCGTTTGTTTTGCCTACTTGGGCAGACAAGGTCATTAATGAATGA","protein_sequence":"MVNNSQHPYIKDGWFREINDKSFPGQAFTMTVDSILYEARSEFQDILIFRNKVYGTVLVLDGIVQCTEFDEFAYQEMITHIAMFAHSNPKRVLIIGGGDGGVLREVAKHSCVEDITMVEIDSSVIELSRKFLPTLSNGAFDDERLDLKLCDGFKFLQDIGASDVHKKFDVIITDSSDPEGPAEAFFQERYFELLKDALNPNGVVIMQSSENFWLNLKYLHDLKNTAKKVFPNTEYCYTMVPTYTSGQLGLIVCSNNANIPLNIPQRKISEQEQGKLKYYNPQIHSSAFVLPTWADKVINE"},{"created_at":"2011-05-27T02:18:58.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Spermidine synthase","uniprot_id":"Q12074","uniprot_name":"SPEE_YEAST","enzyme":true,"transporter":false,"gene_name":"SPE3","num_residues":293,"molecular_weight":"33323.80078","theoretical_pi":"5.24","general_function":"Involved in catalytic activity","specific_function":"S-adenosylmethioninamine + putrescine = 5'-S- methyl-5'-thioadenosine + spermidine","reactions":[{"id":1970,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2670,"direction":"\u003e","locations":null,"altext":"S-adenosylmethioninamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.","export":false,"pw_reaction_id":null,"source":null},{"id":3759,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006283","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U27519","genbank_protein_id":"1326074","gene_card_id":"SPE3","chromosome_location":"chromosome 16","locus":"YPR069C","synonyms":["SPDSY","Putrescine aminopropyltransferase"],"enzyme_classes":["2.5.1.16"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Spermine_synth","identifier":"PF01564"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGGCACAAGAAATCACTCACCCAACTATTGTAGACGGCTGGTTCAGAGAAATTTCTGATACCATGTGGCCAGGCCAGGCCATGACTTTAAAAGTGGAGAAAGTTTTACACCATGAGAAGTCAAAATATCAAGACGTTTTGATCTTCAAATCCACTACATATGGTAATGTTCTAGTTTTAGATAATGTAATTCAAGCCACCGAAAGGGATGAATTTGCCTACCAAGAAATGATTGCCCATCTTGCCTTGAATTCCCATCCAAATCCTAAGAAGGTTCTTGTTATTGGTGGGGGTGATGGTGGTGTTTTGAGAGAGGTTGTCAAGCATGATTCCGTTGAGGAAGCCTGGTTATGTGACATTGATGAAGCTGTTATTAGACTATCAAAGGAGTACCTACCAGAAATGGCTGCCTCTTATTCTCACCCAAAGGTTAAGACCCACATTGGTGATGGTTTCCAATTTTTAAGAGATTACCAAAACACATTTGACGTAATCATTACTGACTCTTCTGACCCAGAAGGTCCAGCTGAAACCCTTTTCCAAAAGGAATATTTCCAATTGTTGAACAGTGCGTTGACAGAAAAGGGTGTAATCACTACACAAGCAGAAAGTATGTGGATTCACTTGCCAATCATTAAGGACTTAAAGAAAGCCTGTTCTGAAGTTTTCCCAGTTGCAGAATACTCTTTCGTTACTATTCCAACTTACCCAACTGGTACGATTGGTTTTATGGTTTGCTCCAAAGATAAAACTTGCAATGTCAAGAAGCCACTACGTGAAATCTCTGATGAGAAGGAGGCTGAATTATACAGATACTATAACAAGAAAATTCACGAAGCTTCCTTTGTTCTACCAACCTGGGCAGCCAAGGAATTAAATTAG","protein_sequence":"MAQEITHPTIVDGWFREISDTMWPGQAMTLKVEKVLHHEKSKYQDVLIFKSTTYGNVLVLDNVIQATERDEFAYQEMIAHLALNSHPNPKKVLVIGGGDGGVLREVVKHDSVEEAWLCDIDEAVIRLSKEYLPEMAASYSHPKVKTHIGDGFQFLRDYQNTFDVIITDSSDPEGPAETLFQKEYFQLLNSALTEKGVITTQAESMWIHLPIIKDLKKACSEVFPVAEYSFVTIPTYPTGTIGFMVCSKDKTCNVKKPLREISDEKEAELYRYYNKKIHEASFVLPTWAAKELN"},{"created_at":"2011-05-27T02:19:33.000Z","updated_at":"2011-07-22T17:54:00.000Z","name":"S-adenosylmethionine decarboxylase proenzyme","uniprot_id":"P21182","uniprot_name":"DCAM_YEAST","enzyme":true,"transporter":false,"gene_name":"SPE2","num_residues":396,"molecular_weight":"46232.0","theoretical_pi":"5.32","general_function":"Involved in adenosylmethionine decarboxylase activity","specific_function":"S-adenosylmethionine decarboxylase is essential for normal growth, sporulation, maintenance of ds-RNA virus, biosynthesis of spermine and spermidine","reactions":[{"id":1273,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2671,"direction":"\u003e","locations":null,"altext":"S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3760,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006284","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M38434","genbank_protein_id":"171055","gene_card_id":"SPE2","chromosome_location":"chromosome 15","locus":"YOL052C","synonyms":["AdoMetDC","SAMDC","S-adenosylmethionine decarboxylase alpha chain","S-adenosylmethionine decarboxylase beta chain"],"enzyme_classes":["4.1.1.50"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" carboxy-lyase activity"},{"category":"Function","description":" adenosylmethionine decarboxylase activity"},{"category":"Process","description":" polyamine biosynthetic process"},{"category":"Process","description":" spermine biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular amino acid derivative metabolic process"},{"category":"Process","description":" cellular biogenic amine metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" spermidine biosynthetic process"},{"category":"Process","description":" polyamine metabolic process"}],"pfams":[{"name":"SAM_decarbox","identifier":"PF01536"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"}],"gene_sequence":"ATGACTGTCACCATAAAAGAATTGACTAACCACAACTACATTGACCACGAACTATCAGCCACTTTAGACTCAACGGATGCGTTCGAGGGTCCCGAGAAGTTGCTGGAAATCTGGTTCTTCCCTCACAAGAAGTCCATCACGACCGAAAAGACATTAAGAAATATTGGCATGGATAGATGGATCGAGATTTTGAAATTAGTGAAATGCGAAGTTCTTTCCATGAAGAAGACTAAAGAACTGGATGCCTTTTTGTTGAGTGAGTCTTCCCTCTTCGTCTTCGATCACAAATTGACGATGAAGACGTGCGGTACTACAACCACATTGTTCTGTCTCGAAAAGCTTTTCCAGATCGTTGAGCAAGAGTTATCGTGGGCTTTCCGCACAACACAAGGGGGCAAGTACAAACCATTTAAAGTGTTTTATTCTAGACGATGTTTCCTTTTCCCCTGTAAGCAAGCCGCTATCCATCAAAACTGGGCTGACGAAGTCGACTATTTGAACAAATTTTTCGACAATGGTAAAAGTTATTCCGTGGGAAGAAATGACAAGAGCAACCACTGGAACCTGTACGTCACCGAGACGGACCGCTCCACACCTAAGGGAAAGGAGTACATCGAGGATGACGACGAAACTTTCGAAGTACTGATGACGGAGCTGGACCCAGAATGCGCTAGTAAGTTTGTTTGCGGGCCTGAGGCATCCACAACCGCTCTCGTGGAGCCAAACGAAGATAAGGGCCACAACCTCGGCTACCAAATGACTAAAAATACAAGGCTTGACGAAATATATGTCAACTCGGCCCAAGACTCCGATTTATCATTTCACCACGATGCATTTGCGTTCACGCCATGTGGATACTCATCCAATATGATTCTCGCTGAAAAATACTATTACACCCTGCACGTGACTCCGGAAAAGGGTTGGTCTTACGCCTCTTTCGAAAGTAACATACCCGTATTTGACATTTCCCAAGGGAAGCAAGACAACTTGGACGTTCTTCTACATATTCTGAACGTTTTTCAACCAAGAGAGTTCTCGATGACCTTTTTTACCAAAAATTATCAGAACCAATCCTTCCAAAAACTACTAAGCATCAACGAGTCACTGCCCGACTACATCAAGTTAGACAAAATTGTTTATGATCTGGACGACTACCACCTTTTCTATATGAAATTGCAGAAGAAAATATGA","protein_sequence":"MTVTIKELTNHNYIDHELSATLDSTDAFEGPEKLLEIWFFPHKKSITTEKTLRNIGMDRWIEILKLVKCEVLSMKKTKELDAFLLSESSLFVFDHKLTMKTCGTTTTLFCLEKLFQIVEQELSWAFRTTQGGKYKPFKVFYSRRCFLFPCKQAAIHQNWADEVDYLNKFFDNGKSYSVGRNDKSNHWNLYVTETDRSTPKGKEYIEDDDETFEVLMTELDPECASKFVCGPEASTTALVEPNEDKGHNLGYQMTKNTRLDEIYVNSAQDSDLSFHHDAFAFTPCGYSSNMILAEKYYYTLHVTPEKGWSYASFESNIPVFDISQGKQDNLDVLLHILNVFQPREFSMTFFTKNYQNQSFQKLLSINESLPDYIKLDKIVYDLDDYHLFYMKLQKKI"}]}