{"ymdb_id":"YMDB00746","created_at":"2011-05-29T18:49:23.000Z","updated_at":"2016-09-08T18:35:51.000Z","name":"dUDP","cas":"4208-67-7","state":"Solid","melting_point":null,"description":"Deoxyuracile diphosphate (dUDP) is a deoxyribonucleoside diphosphate. It is a intermediate in pyrimidine metabolism.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"nucleus;cytoplasm","synthesis_reference":null,"chebi_id":"28850","hmdb_id":"HMDB01000","kegg_id":"C01346","pubchem_id":"687","cs_id":"24785517","foodb_id":null,"wikipedia_link":null,"biocyc_id":"DUDP","iupac":"[({[(2R,3S,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid","traditional_iupac":"dUDP","logp":"-2.0599685889999995","pka":"3.210405158752114","alogps_solubility":"8.03e+00 g/l","alogps_logp":"-0.99","alogps_logs":"-1.68","acceptor_count":"9","donor_count":"5","rotatable_bond_count":"6","polar_surface_area":"192.15999999999994","refractivity":"72.8007","polarizability":"29.831689347500404","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.240344155883659","pka_strongest_acidic":"1.7717479360816935","bioavailability":"1","number_of_rings":"2","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["2-deoxyuridine 5-diphosphate","2'-Deoxyuridine 5'-diphosphate","2'-deoxyuridine-5'-diphosphate","deoxyuridine-diphosphate","dUDP"],"pathways":[{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":8223452,"citation":"Gadsden, M. H., McIntosh, E. M., Game, J. C., Wilson, P. J., Haynes, R. H. (1993). \"dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae.\" EMBO J 12:4425-4431."}],"proteins":[{"created_at":"2011-05-26T16:39:20.000Z","updated_at":"2011-05-27T15:01:00.000Z","name":"Uridylate kinase","uniprot_id":"P15700","uniprot_name":"UMPK_YEAST","enzyme":true,"transporter":false,"gene_name":"URA6","num_residues":204,"molecular_weight":"22933.0","theoretical_pi":"6.53","general_function":"Involved in ATP binding","specific_function":"Furnishes the cell with pyrimidines. Accepts UMP, and dUMP as phosphate acceptors with high activity; to a lesser extent, it can also use IMP, GMP, dGMP, 5-iodo-dUMP, XMP, and dTMP as substrates. ATP and dATP are the best phosphate donors; can use GTP, dGTP, dCTP, and dTTP to some degree (30-50%)","reactions":[{"id":2033,"direction":"\u003c\u003e","locations":"cytoplasm;nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2039,"direction":"\u003c\u003e","locations":"cytoplasm;nucleus","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2436,"direction":"\u003e","locations":"Cytoplasm. Nucleus.","altext":"ATP + UMP = ADP + UDP.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1UKZ","cellular_location":"Cytoplasm. Nucleus.","genbank_gene_id":"AY558074","genbank_protein_id":"45270038","gene_card_id":"URA6","chromosome_location":"chromosome 11","locus":"YKL024C","synonyms":["UK","Uridine monophosphate kinase","UMP kinase"],"enzyme_classes":["2.7.4.-"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" phosphotransferase activity, phosphate group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" nucleobase, nucleoside, nucleotide kinase activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" kinase activity"},{"category":"Function","description":" nucleotide kinase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"}],"pfams":[{"name":"ADK","identifier":"PF00406"}],"pathways":[],"gene_sequence":"ATGACAGCTGCCACTACATCACAGCCAGCTTTCTCGCCTGACCAAGTTTCCGTGATCTTCGTTCTAGGAGGACCCGGTGCAGGCAAGGGTACTCAGTGTGAAAAACTAGTTAAGGACTATTCATTTGTCCATTTGTCAGCCGGAGACCTTCTACGTGCTGAGCAGGGCAGAGCAGGTTCCCAATATGGGGAATTGATCAAGAACTGCATCAAAGAGGGCCAGATTGTCCCTCAAGAGATTACTTTGGCGCTTTTACGCAACGCTATTTCCGATAACGTCAAGGCGAACAAGCATAAGTTCTTAATTGACGGATTTCCTAGGAAGATGGATCAAGCCATTTCCTTTGAAAGAGACATCGTTGAAAGCAAATTCATCCTGTTCTTTGACTGCCCTGAAGATATCATGTTAGAGAGACTATTGGAGCGTGGCAAGACCAGTGGTAGAAGCGATGACAACATTGAGTCCATTAAGAAGAGATTTAACACTTTCAAGGAGACTAGTATGCCCGTCATCGAGTACTTTGAAACCAAATCGAAAGTCGTCCGTGTTCGTTGCGACAGATCCGTCGAAGATGTGTACAAAGACGTCCAAGACGCTATCCGTGATAGCTTATAG","protein_sequence":"MTAATTSQPAFSPDQVSVIFVLGGPGAGKGTQCEKLVKDYSFVHLSAGDLLRAEQGRAGSQYGELIKNCIKEGQIVPQEITLALLRNAISDNVKANKHKFLIDGFPRKMDQAISFERDIVESKFILFFDCPEDIMLERLLERGKTSGRSDDNIESIKKRFNTFKETSMPVIEYFETKSKVVRVRCDRSVEDVYKDVQDAIRDSL"},{"created_at":"2011-05-26T16:56:27.000Z","updated_at":"2011-05-29T05:06:19.000Z","name":"Ribonucleoside-diphosphate reductase small chain 1","uniprot_id":"P09938","uniprot_name":"RIR2_YEAST","enzyme":true,"transporter":false,"gene_name":"RNR2","num_residues":399,"molecular_weight":"46147.0","theoretical_pi":"4.9","general_function":"Involved in oxidoreductase activity","specific_function":"Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR2 provides the diiron-tyrosyl radical center","reactions":[{"id":2453,"direction":"\u003e","locations":"Cytoplasm;Nucleus.","altext":"2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1SMQ","cellular_location":"Nucleus.","genbank_gene_id":"M17221","genbank_protein_id":"172448","gene_card_id":"RNR2","chromosome_location":"chromosome 10","locus":"YJL026W","synonyms":["Ribonucleotide reductase R2 subunit 1","Ribonucleotide reductase small subunit 1"],"enzyme_classes":["1.17.4.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor"},{"category":"Function","description":" ribonucleoside-diphosphate reductase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" nucleoside diphosphate metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" deoxyribonucleoside diphosphate metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Ribonuc_red_sm","identifier":"PF00268"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGCCTAAAGAGACCCCTTCCAAAGCTGCTGCCGATGCATTGTCCGACTTGGAAATCAAAGATTCCAAGTCCAACCTTAACAAGGAATTGGAGACATTGAGAGAGGAAAACAGAGTAAAGTCAGACATGCTTAAGGAGAAATTGAGCAAGGACGCTGAAAATCACAAGGCTTACTTGAAATCTCATCAAGTTCACCGTCACAAACTTAAGGAAATGGAAAAGGAGGAACCTTTGTTGAATGAAGACAAGGAGAGAACTGTTCTTTTCCCTATCAAGTACCATGAAATCTGGCAAGCCTACGAAGCTTCTTTCTGGACCGCTGAAACCGCTGAAGAAATTGATTTGTCTAAGGATATCCATGACTGGAACAACAGAATGAACGAAAACGAGAGATTTTTCATTTCCAGAGTTCTTGCCTTTTTCGCCGCTTCTGACGGTATTGTTAATGAAAACTTGGTTGAAAACTTCTCCACCGAAGTCCAAATTCCAGAGGCAAAGAGTTTCTACGGTTTCCAAATCATGATTGAAAATATTCACTCTGAAACTTACTCCTTGTTGATCGATACTTACATCAAGGACCCTAAAGAAAGTGAATTCTTGTTCAATGCCATTCACACCATCCCAGAAATCGGTGAGAAGGCCGAATGGGCTTTAAGATGGATTCAAGACGCTGACGCCTTGTTTGGTGAAAGACTAGTTGCCTTTGCCTCCATTGAAGGTGTCTTTTTCTCCGGTTCCTTTGCCTCCATTTTCTGGTTGAAAAAGAGAGGTATGATGCCCGGTTTAACCTTTTCCAACGAATTGATCTGTAGAGACGAAGGTTTGCACACCGACTTTGCATGCTTGTTGTTCGCCCATTTGAAGAACAAACCAGACCCAGCCATTGTTGAAAAAATTGTCACCGAGGCTGTGGAAATTGAACAAAGATACTTCTTGGACGCCTTACCAGTTGCTTTGCTAGGTATGAACGCTGACTTAATGAACCAATACGTTGAGTTCGTCGCCGACAGACTGTTGGTTGCTTTCGGTAACAAGAAATACTACAAGGTCGAAAACCCCTTCGATTTCATGGAAAACATCTCCTTGGCCGGTAAGACCAACTTCTTCGAAAAGAGAGTTTCTGACTACCAAAAGGCTGGTGTTATGTCCAAGTCGACTAAGCAAGAAGCCGGTGCTTTCACCTTCAACGAAGACTTTTAA","protein_sequence":"MPKETPSKAAADALSDLEIKDSKSNLNKELETLREENRVKSDMLKEKLSKDAENHKAYLKSHQVHRHKLKEMEKEEPLLNEDKERTVLFPIKYHEIWQAYKRAEASFWTAEEIDLSKDIHDWNNRMNENERFFISRVLAFFAASDGIVNENLVENFSTEVQIPEAKSFYGFQIMIENIHSETYSLLIDTYIKDPKESEFLFNAIHTIPEIGEKAEWALRWIQDADALFGERLVAFASIEGVFFSGSFASIFWLKKRGMMPGLTFSNELICRDEGLHTDFACLLFAHLKNKPDPAIVEKIVTEAVEIEQRYFLDALPVALLGMNADLMNQYVEFVADRLLVAFGNKKYYKVENPFDFMENISLAGKTNFFEKRVSDYQKAGVMSKSTKQEAGAFTFNEDF"},{"created_at":"2011-05-26T16:57:01.000Z","updated_at":"2011-05-27T15:01:01.000Z","name":"Nucleoside diphosphate kinase","uniprot_id":"P36010","uniprot_name":"NDK_YEAST","enzyme":true,"transporter":false,"gene_name":"YNK1","num_residues":153,"molecular_weight":"17166.59961","theoretical_pi":"9.05","general_function":"Involved in nucleoside diphosphate kinase activity","specific_function":"Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Required for repair of UV radiation- and etoposide-induced DNA damage","reactions":[{"id":1786,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1787,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1788,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1789,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1790,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1791,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1792,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1793,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1794,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2454,"direction":"\u003e","locations":"Cytoplasm. Mitochondrion intermembrane space.","altext":"ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Mitochondrion intermembrane space.","genbank_gene_id":"AY558263","genbank_protein_id":"45270416","gene_card_id":"YNK1","chromosome_location":"chromosome 11","locus":"YKL067W","synonyms":["NDK","NDP kinase"],"enzyme_classes":["2.7.4.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, phosphate group as acceptor"},{"category":"Function","description":" nucleoside diphosphate kinase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" pyrimidine nucleotide metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" pyrimidine nucleotide biosynthetic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" purine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" purine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" CTP biosynthetic process"},{"category":"Process","description":" purine nucleotide metabolic process"},{"category":"Process","description":" pyrimidine nucleoside triphosphate biosynthetic process"},{"category":"Process","description":" purine nucleotide biosynthetic process"},{"category":"Process","description":" pyrimidine ribonucleoside triphosphate biosynthetic process"},{"category":"Process","description":" UTP biosynthetic process"},{"category":"Process","description":" GTP biosynthetic process"}],"pfams":[{"name":"NDK","identifier":"PF00334"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"}],"gene_sequence":"ATGTCTAGTCAAACAGAAAGAACTTTTATTGCGGTAAAACCAGATGGTGTCCAGAGGGGCTTAGTATCTCAAATTCTATCTCGTTTTGAAAAAAAAGGTTACAAACTAGTTGCTATTAAATTAGTTAAAGCGGATGATAAATTACTAGAGCAACATTACGCAGAGCATGTTGGTAAACCATTTTTCCCAAAGATGGTATCCTTTATGAAGTCTGGTCCCATTTTGGCCACGGTCTGGGAGGGAAAAGATGTGGTTAGACAAGGAAGAACTATTCTTGGTGCTACTAATCCTTTGGGCAGTGCACCAGGTACCATTAGAGGTGATTTCGGTATTGACCTAGGCAGAAACGTCTGTCACGGCAGTGATTCTGTTGATAGCGCTGAACGTGAAATCAATTTGTGGTTTAAGAAGGAAGAGTTAGTTGATTGGGAATCTAATCAAGCTAAGTGGATTTATGAATGA","protein_sequence":"MSSQTERTFIAVKPDGVQRGLVSQILSRFEKKGYKLVAIKLVKADDKLLEQHYAEHVGKPFFPKMVSFMKSGPILATVWEGKDVVRQGRTILGATNPLGSAPGTIRGDFGIDLGRNVCHGSDSVDSAEREINLWFKKEELVDWESNQAKWIYE"},{"created_at":"2011-05-26T16:58:03.000Z","updated_at":"2011-05-29T05:06:19.000Z","name":"Ribonucleoside-diphosphate reductase large chain 1","uniprot_id":"P21524","uniprot_name":"RIR1_YEAST","enzyme":true,"transporter":false,"gene_name":"RNR1","num_residues":888,"molecular_weight":"99560.20313","theoretical_pi":"6.1","general_function":"Involved in oxidation-reduction process","specific_function":"Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides","reactions":[{"id":2453,"direction":"\u003e","locations":"Cytoplasm;Nucleus.","altext":"2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.","export":false,"pw_reaction_id":null,"source":null},{"id":14262,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006740","source":"Smpdb"},{"id":14274,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006749","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U18813","genbank_protein_id":"603306","gene_card_id":"RNR1","chromosome_location":"chromosome 5","locus":"YER070W","synonyms":["Ribonucleotide reductase R1 subunit 1","Ribonucleotide reductase large subunit 1"],"enzyme_classes":["1.17.4.1"],"go_classes":[{"category":"Component","description":" ribonucleoside-diphosphate reductase complex"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor"},{"category":"Function","description":" ribonucleoside-diphosphate reductase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" protein binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" DNA metabolic process"},{"category":"Process","description":" DNA replication"},{"category":"Process","description":" cellular macromolecule metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"ATP-cone","identifier":"PF03477"},{"name":"Ribonuc_red_lgC","identifier":"PF02867"},{"name":"Ribonuc_red_lgN","identifier":"PF00317"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGTACGTTTATAAAAGAGACGGTCGTAAAGAACCTGTCCAATTCGATAAGATTACCGCTCGTATATCACGCTTATGCTATGGTTTAGATCCAAAACATATCGACGCCGTTAAGGTCACCCAACGTATCATTTCTGGTGTCTATGAAGGTGTCACAACAATCGAACTAGACAACTTAGCCGCTGAAACATGCGCTTATATGACTACTGTTCATCCAGATTACGCCACCCTAGCGGCCAGAATTGCCATTTCTAATTTACATAAACAAACCACAAAACAATTTTCTAAGGTTGTCGAAGATCTTTATAGATACGTCAATGCTGCTACTGGTAAGCCCGCTCCCATGATCTCTGATGATGTCTACAATATTGTCATGGAAAACAAGGATAAATTGAACTCCGCAATTGTCTATGACAGAGATTTTCAGTACAGTTATTTTGGTTTTAAAACTTTGGAACGTTCTTATTTACTAAGAATCAACGGTCAAGTGGCCGAACGTCCACAACATTTAATTATGAGAGTCGCACTAGGCATCCACGGTAGAGATATCGAGGCTGCTTTAGAAACGTATAACTTGATGTCTCTAAAATATTTTACTCACGCCTCTCCAACGTTGTTCAATGCCGGTACTCCAAAACCTCAAATGTCCTCTTGTTTCTTGGTTGCCATGAAGGAGGACTCTATCGAGGGGATTTACGACACCTTGAAGGAATGTGCTTTGATTTCCAAAACTGCTGGTGGTATTGGTCTACATATCCATAACATTCGTTCAACTGGTTCTTACATTGCTGGTACAAACGGTACTTCTAACGGTTTAATTCCTATGATTCGTGTTTTCAATAACACTGCCCGTTATGTTGACCAGGGTGGTAATAAAAGACCTGGTGCGTTTGCCCTTTACCTGGAACCATGGCATGCTGATATATTTGATTTTATTGATATTAGGAAGAACCACGGTAAAGAGGAAATTCGTGCAAGAGATTTGTTCCCTGCTCTATGGATTCCTGATCTTTTCATGAAGCGTGTCGAAGAAAATGGGACCTGGACATTATTCTCTCCAACATCAGCTCCTGGTTTAAGCGATTGTTACGGTGACGAGTTTGAGGCTCTATATACCCGCTACGAGAAAGAAGGTCGTGGTAAGACTATCAAAGCCCAAAAATTATGGTATTCCATTTTGGAAGCTCAAACTGAAACTGGTACACCTTTCGTTGTTTACAAGGATGCTTGTAACAGAAAATCTAATCAAAAAAACTTAGGTGTCATCAAGTCATCAAACTTATGCTGTGAAATTGTTGAATACTCAGCTCCAGATGAAACTGCTGTTTGTAACTTGGCTTCCGTTGCCTTACCAGCATTCATTGAAACTTCTGAGGATGGTAAGACTTCCACATACAACTTCAAAAAATTACATGAAATTGCTAAAGTTGTTACTCGTAATTTAAACAGAGTCATTGATCGTAATTACTACCCTGTTGAAGAAGCGAGAAAATCCAATATGAGACATAGACCAATTGCTTTGGGTGTTCAAGGTCTCGCTGACACTTTCATGCTGTTACGTTTGCCATTTGATTCTGAGGAAGCCCGTTTGCTAAATATCCAAATCTTTGAAACTATTTATCATGCCTCCATGGAAGCTTCTTGTGAACTAGCTCAGAAGGACGGTCCATACGAAACTTTCCAAGGATCTCCTGCTTCTCAAGGTATACTACAGTTTGATATGTGGGACCAAAAACCCTACGGCATGTGGGATTGGGACACCTTAAGAAAAGATATCATGAAGCATGGTGTTAGAAATTCCTTGACCATGGCACCAATGCCTACTGCATCCACATCCCAAATATTGGGTTATAATGAATGTTTCGAACCAGTCACTTCCAATATGTACTCCCGTCGTGTCTTATCCGGTGAATTCCAGGTTGTGAACCCTTACTTACTGCGTGACTTGGTTGATTTAGGTATTTGGGATGAGGGTATGAAACAGTATCTGATTACACAAAATGGCTCCATTCAAGGCTTACCAAACGTTCCACAAGAATTGAAGGACTTATACAAGACTGTTTGGGAAATTTCACAAAAGACTATCATTAACATGGCAGCCGATCGTTCTGTCTATATTGATCAATCTCATTCTTTGAATTTGTTCTTACGTGCCCCAACTATGGGTAAACTAACAAGTATGCATTTTTACGGATGGAAGAAGGGATTGAAGACCGGTATGTACTATTTGAGAACCCAAGCTGCATCTGCTGCAATTCAATTTACTATTGATCAGAAGATTGCGGATCAAGCTACAGAAAACGTTGCTGATATTTCCAACTTGAAGCGTCCATCATATATGCCTTCCAGTGCAAGCTACGCTGCCAGCGATTTCGTGCCCGCAGCTGTGACTGCAAACGCAACTATTCCATCTCTAGATAGCTCCTCGGAAGCTTCAAGAGAGGCATCTCCAGCTCCAACAGGTAGCCACTCATTAACTAAAGGAATGGCAGAATTAAACGTTCAAGAGTCTAAGGTAGAAGTTCCTGAAGTACCTGCCCCAACTAAGAATGAAGAAAAAGCTGCCCCCATCGTTGATGATGAGGAAACCGAGTTCGACATTTACAACTCTAAGGTTATAGCATGTGCTATTGATAACCCAGAAGCTTGTGAAATGTGTTCGGGTTAA","protein_sequence":"MYVYKRDGRKEPVQFDKITARISRLCYGLDPKHIDAVKVTQRIISGVYEGVTTIELDNLAAETCAYMTTVHPDYATLAARIAISNLHKQTTKQFSKVVEDLYRYVNAATGKPAPMISDDVYNIVMENKDKLNSAIVYDRDFQYSYFGFKTLERSYLLRINGQVAERPQHLIMRVALGIHGRDIEAALETYNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDSIEGIYDTLKECALISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVDQGGNKRPGAFALYLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMKRVEENGTWTLFSPTSAPGLSDCYGDEFEALYTRYEKEGRGKTIKAQKLWYSILEAQTETGTPFVVYKDACNRKSNQKNLGVIKSSNLCCEIVEYSAPDETAVCNLASVALPAFIETSEDGKTSTYNFKKLHEIAKVVTRNLNRVIDRNYYPVEEARKSNMRHRPIALGVQGLADTFMLLRLPFDSEEARLLNIQIFETIYHASMEASCELAQKDGPYETFQGSPASQGILQFDMWDQKPYGMWDWDTLRKDIMKHGVRNSLTMAPMPTASTSQILGYNECFEPVTSNMYSRRVLSGEFQVVNPYLLRDLVDLGIWDEGMKQYLITQNGSIQGLPNVPQELKDLYKTVWEISQKTIINMAADRSVYIDQSHSLNLFLRAPTMGKLTSMHFYGWKKGLKTGMYYLRTQAASAAIQFTIDQKIADQATENVADISNLKRPSYMPSSASYAASDFVPAAVTANATIPSLDSSSEASREASPAPTGSHSLTKGMAELNVQESKVEVPEVPAPTKNEEKAAPIVDDEETEFDIYNSKVIACAIDNPEACEMCSG"},{"created_at":"2011-05-27T05:35:58.000Z","updated_at":"2011-05-29T05:06:42.000Z","name":"Ribonucleoside-diphosphate reductase small chain 2","uniprot_id":"P49723","uniprot_name":"RIR4_YEAST","enzyme":true,"transporter":false,"gene_name":"RNR4","num_residues":345,"molecular_weight":"40054.19922","theoretical_pi":"4.86","general_function":"Involved in oxidoreductase activity","specific_function":"Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. RNR4 is required for proper folding of RNR2 and assembly with the large subunits","reactions":[{"id":2453,"direction":"\u003e","locations":"Cytoplasm;Nucleus.","altext":"2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.","export":false,"pw_reaction_id":null,"source":null},{"id":14274,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006749","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1SMS","cellular_location":"Nucleus.","genbank_gene_id":"AY723819","genbank_protein_id":"51830370","gene_card_id":"RNR4","chromosome_location":"chromosome 7","locus":"YGR180C","synonyms":["Ribonucleotide reductase R2 subunit 2","Ribonucleotide reductase small subunit 2"],"enzyme_classes":["1.17.4.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups"},{"category":"Function","description":" oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor"},{"category":"Function","description":" ribonucleoside-diphosphate reductase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" nucleoside diphosphate metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"},{"category":"Process","description":" cellular nitrogen compound metabolic process"},{"category":"Process","description":" deoxyribonucleoside diphosphate metabolic process"},{"category":"Process","description":" nucleobase, nucleoside, nucleotide and nucleic acid metabolic process"},{"category":"Process","description":" nucleobase, nucleoside and nucleotide metabolic process"},{"category":"Process","description":" nucleoside phosphate metabolic process"},{"category":"Process","description":" nucleotide metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"Ribonuc_red_sm","identifier":"PF00268"}],"pathways":[{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Pyrimidine metabolism","kegg_map_id":"00240"},{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGGAAGCACATAACCAATTTTTGAAGACTTTCCAAAAAGAACGTCATGATATGAAAGAAGCTGAAAAGGATGAAATCCTTTTGATGGAAAACAGCCGTAGATTCGTGATGTTCCCTATCAAATACCACGAAATCTGGGCTGCTTACAAGAAGGTTGAAGCCTCTTTCTGGACTGCGGAAGAAATCGAATTGGCTAAGGACACTGAAGATTTCCAAAAATTGACTGATGACCAGAAGACCTACATCGGTAACTTGTTAGCCTTGTCCATTTCTTCTGACAACCTTGTCAACAAGTACTTGATCGAAAACTTTTCTGCCCAATTGCAAAACCCTGAAGGTAAGAGTTTCTACGGGTTCCAGATTATGATGGAAAACATCCACTCTGAAGTTTACTCCATGATGGTTGATGCCTTCTTCAAGGACCCTAAGAACATCCCTCTATTCAAGGAAATTGCCAATTTGCCTGAAGTCAAGCATAAGGCTGCTTTCATCGAGAGATGGATTTCCAACGATGACAGCTTGTATGCTGAAAGACTAGTAGCATTTGCTGCAAAGGAAGGTATTTTCCAAGCTGGTAACTATGCTTCTATGTTCTGGTTGACTGACAAAAAGATTATGCCAGGTTTAGCAATGGCCAACAGAAACATCTGTAGAGACAGAGGTGCCTACACTGACTTTTCATGCTTGCTATTTGCCCATTTGAGAACCAAGCCAAACCCCAAGATCATTGAAAAAATCATTACCGAAGCCGTGGAAATTGAAAAGGAATACTACTCAAACTCTTTGCCAGTAGAAAAATTTGGTATGGATTTGAAGAGCATTCACACCTACATAGAATTTGTCGCTGACGGTCTATTACAAGGTTTCGGTAACGAAAAATACTACAACGCCGTCAACCCATTCGAATTCATGGAGGATGTCGCTACCGCTGGTAAGACCACCTTCTTTGAAAAGAAGGTTTCCGACTACCAAAAGGCCAGTGACATGTCTAAGTCCGCTACCCCATCCAAGGAAATTAACTTTGATGATGACTTCTAA","protein_sequence":"MEAHNQFLKTFQKERHDMKEAEKDEILLMENSRRFVMFPIKYHEIWAAYKKVEASFWTAEEIELAKDTEDFQKLTDDQKTYIGNLLALSISSDNLVNKYLIENFSAQLQNPEGKSFYGFQIMMENIYSEVYSMMVDAFFKDPKNIPLFKEIANLPEVKHKAAFIERWISNDDSLYAERLVAFAAKEGIFQAGNYASMFWLTDKKIMPGLAMANRNICRDRGAYTDFSCLLFAHLRTKPNPKIIEKIITEAVEIEKEYYSNSLPVEKFGMDLKSIHTYIEFVADGLLQGFGNEKYYNAVNPFEFMEDVATAGKTTFFEKKVSDYQKASDMSKSATPSKEINFDDDF"}]}