{"ymdb_id":"YMDB00888","created_at":"2011-05-29T19:01:33.000Z","updated_at":"2016-09-08T18:36:01.000Z","name":"Hydrogen peroxide","cas":"7722-84-1","state":"Liquid","melting_point":"-0.43 oC","description":"Hydrogen peroxide (H2O2) plays important roles in host defense and oxidative biosynthetic reactions and is naturally produced in organisms as a by-product of oxidative metabolism. Catalase peroxidases decompose low concentrations of hydrogen peroxide to water and oxygen.","experimental_water_solubility":"1000 mg/mL at 25 oC [RADDING,SB et al. (1977)]","experimental_logp_hydrophobicity":"","location":"mitochondrion;nucleus;peroxisome;cytoplasm","synthesis_reference":null,"chebi_id":"16240","hmdb_id":"HMDB03125","kegg_id":"C00027","pubchem_id":"784","cs_id":"763","foodb_id":null,"wikipedia_link":"Hydrogen peroxide","biocyc_id":"HYDROGEN-PEROXIDE","iupac":"peroxol","traditional_iupac":"hydrogen peroxide","logp":"-0.447202414","pka":"14.397218846455527","alogps_solubility":null,"alogps_logp":null,"alogps_logs":null,"acceptor_count":"2","donor_count":"2","rotatable_bond_count":"0","polar_surface_area":"40.46","refractivity":"5.1292","polarizability":"2.291055697453342","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"-4.189015938635916","pka_strongest_acidic":"11.520607090216412","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["Hydrogen dioxide"],"pathways":[{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Porphyrin Metabolism","kegg_map_id":null},{"name":"Vitamin B6","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":16347719,"citation":"Verduyn, C., Giuseppin, M. L., Scheffers, W. A., van Dijken, J. P. (1988). \"Hydrogen peroxide metabolism in yeasts.\" Appl Environ Microbiol 54:2086-2090."},{"pubmed_id":12697341,"citation":"Hiltunen, J. K., Mursula, A. M., Rottensteiner, H., Wierenga, R. K., Kastaniotis, A. J., Gurvitz, A. (2003). \"The biochemistry of peroxisomal beta-oxidation in the yeast Saccharomyces cerevisiae.\" FEMS Microbiol Rev 27:35-64."},{"pubmed_id":9837886,"citation":"Geisbrecht, B. V., Zhu, D., Schulz, K., Nau, K., Morrell, J. C., Geraghty, M., Schulz, H., Erdmann, R., Gould, S. J. (1998). \"Molecular characterization of Saccharomyces cerevisiae Delta3, Delta2-enoyl-CoA isomerase.\" J Biol Chem 273:33184-33191."},{"pubmed_id":10508108,"citation":"Lee, B. H., Huh, W. K., Kim, S. T., Lee, J. S., Kang, S. O. (1999). \"Bacterial production of D-erythroascorbic acid and L-ascorbic acid through functional expression of Saccharomyces cerevisiae D-arabinono-1,4-lactone oxidase in Escherichia coli.\" Appl Environ Microbiol 65:4685-4687."}],"proteins":[{"created_at":"2011-05-24T19:11:10.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"Glutathione peroxidase 2","uniprot_id":"P38143","uniprot_name":"GPX2_YEAST","enzyme":true,"transporter":false,"gene_name":"GPX2","num_residues":162,"molecular_weight":"18406.0","theoretical_pi":"8.84","general_function":"Involved in glutathione peroxidase activity","specific_function":"May constitute a glutathione peroxidase-like protective system against oxidative stresses","reactions":[{"id":1584,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2240,"direction":"\u003e","locations":"","altext":"2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":2241,"direction":"\u003e","locations":"Cytoplasm","altext":"2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + H2O","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY557641","genbank_protein_id":"45269175","gene_card_id":"GPX2","chromosome_location":"chromosome 2","locus":"YBR244W","synonyms":[],"enzyme_classes":["1.11.1.9","1.11.1.12"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" antioxidant activity"},{"category":"Function","description":" peroxidase activity"},{"category":"Function","description":" glutathione peroxidase activity"},{"category":"Process","description":" response to stimulus"},{"category":"Process","description":" response to stress"},{"category":"Process","description":" response to oxidative stress"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"GSHPx","identifier":"PF00255"}],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Arachidonic acid 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oxidase","uniprot_id":"P54783","uniprot_name":"ALO_YEAST","enzyme":true,"transporter":false,"gene_name":"ALO1","num_residues":526,"molecular_weight":"59493.19922","theoretical_pi":"6.78","general_function":"Involved in D-arabinono-1,4-lactone oxidase activity","specific_function":"Can oxidize L-gulono-1,4-lactone as well as D-arabinono- 1,4-lactone and L-galactono-1,4-lactone","reactions":[{"id":1431,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2293,"direction":"\u003e","locations":"Mitochondrion membrane.","altext":"D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion membrane.","genbank_gene_id":"AB009401","genbank_protein_id":"2696034","gene_card_id":"ALO1","chromosome_location":"chromosome 13","locus":"YML086C","synonyms":["ALO","L-galactono-gamma-lactone oxidase"],"enzyme_classes":["1.1.3.37"],"go_classes":[{"category":"Component","description":" membrane"},{"category":"Component","description":" cell part"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor"},{"category":"Function","description":" D-arabinono-1,4-lactone oxidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" biosynthetic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"ALO","identifier":"PF04030"},{"name":"FAD_binding_4","identifier":"PF01565"}],"pathways":[],"gene_sequence":"ATGTCTACTATCCCATTTAGAAAGAACTATGTGTTCAAAAACTGGGCCGGAATTTATTCTGCAAAACCAGAACGTTACTTCCAACCAAGTTCAATTGATGAGGTTGTCGAGTTAGTAAAGAGTGCCAGGCTAGCTGAAAAAAGCTTAGTTACTGTTGGTTCGGGCCATTCTCCTAGTAACATGTGCGTTACTGATGAATGGCTTGTTAACTTAGACAGATTGGACAAAGTACAAAAGTTTGTTGAATATCCTGAGTTACATTATGCCGATGTCACAGTTGATGCCGGTATGAGGCTTTACCAATTGAATGAATTTTTGGGTGCGAAAGGTTACTCTATCCAAAATTTAGGCTCTATCTCAGAACAAAGTGTTGCTGGCATAATCTCTACTGGTAGTCATGGTTCCTCACCTTATCACGGTTTGATTTCTTCTCAATACGTAAACTTGACTATTGTTAATGGTAAGGGCGAATTGAAGTTCTTGGATGCCGAAAACGATCCAGAAGTCTTTAAAGCTGCTTTACTTTCAGTTGGAAAAATCGGTATCATTGTCTCTGCTACTATCAGGGTTGTTCCCGGCTTCAATATTAAATCCACTCAAGAAGTGATTACTTTTGAAAACCTTTTGAAGCAATGGGATACCCTATGGACTTCATCTGAATTTATCAGAGTTTGGTGGTACCCTTATACTAGAAAATGTGTTCTATGGAGGGGTAACAAAACTACAGATGCCCAAAATGGTCCAGCCAAGTCATGGTGGGGTACCAAGCTGGGTAGATTTTTCTACGAAACTCTATTATGGATCTCTACCAAAATCTATGCGCCATTAACCCCATTTGTGGAAAAGTTCGTTTTCAACAGGCAATACGGGAAATTGGAGAAGAGCTCTACTGGTGATGTTAATGTTACCGATTCTATCAGCGGATTTAATATGGACTGTTTGTTTTCACAATTTGTTGATGAATGGGGGTGCCCTATGGATAATGGTTTGGAAGTCTTACGTTCATTGGATCATTCTATTGCGCAGGCTGCCATAAACAAAGAATTTTATGTCCACGTGCCTATGGAAGTCCGTTGCTCAAATACTACATTACCTTCTGAACCCTTGGATACTAGCAAGAGAACAAACACCAGTCCCGGTCCCGTTTATGGCAATGTGTGCCGCCCATTCCTGGATAACACACCATCCCATTGCAGATTTGCTCCGTTGGAAAATGTTACCAACAGTCAGTTGACGTTGTACATAAATCCTACCATTTATAGGCCGTTTGGCTGTAATACTCCAATTCATAAATGGTTTACCCTTTTTGAAAATACTATGATGGTAGCGGGAGGTAAGCCACATTGGGCCAAGAACTTCCTAGGCTCAACCACTCTAGCTGCTGGACCAGTGAAAAAGGATACTGATTACGATGACTTTGAAATGAGGGGGATGGCATTGAAGGTTGAAGAATGGTATGGCGAGGATTTGAAAAAGTTCCGGAAAATAAGAAAGGAGCAAGATCCCGATAATGTATTCTTGGCAAACAAACAGTGGGCTATCATAAATGGTATTATAGATCCTAGTGAGTTGTCCGACTAG","protein_sequence":"MSTIPFRKNYVFKNWAGIYSAKPERYFQPSSIDEVVELVKSARLAEKSLVTVGSGHSPSNMCVTDEWLVNLDRLDKVQKFVEYPELHYADVTVDAGMRLYQLNEFLGAKGYSIQNLGSISEQSVAGIISTGSHGSSPYHGLISSQYVNLTIVNGKGELKFLDAENDPEVFKAALLSVGKIGIIVSATIRVVPGFNIKSTQEVITFENLLKQWDTLWTSSEFIRVWWYPYTRKCVLWRGNKTTDAQNGPAKSWWGTKLGRFFYETLLWISTKIYAPLTPFVEKFVFNRQYGKLEKSSTGDVNVTDSISGFNMDCLFSQFVDEWGCPMDNGLEVLRSLDHSIAQAAINKEFYVHVPMEVRCSNTTLPSEPLDTSKRTNTSPGPVYGNVCRPFLDNTPSHCRFAPLENVTNSQLTLYINATIYRPFGCNTPIHKWFTLFENTMMVAGGKPHWAKNFLGSTTLAAGPVKKDTDYDDFEMRGMALKVEEWYGEDLKKFRKIRKEQDPDNVFLANKQWAIINGIIDPSELSD"},{"created_at":"2011-05-24T21:00:56.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Pyridoxamine 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(PLP)","reactions":[{"id":1923,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1924,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1926,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1928,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2356,"direction":"\u003e","locations":null,"altext":"Pyridoxamine 5'-phosphate + H(2)O + O(2) = pyridoxal 5'-phosphate + NH(3) + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2357,"direction":"\u003e","locations":null,"altext":"Pyridoxine 5'-phosphate + O(2) = pyridoxal 5'-phosphate + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1CI0","cellular_location":null,"genbank_gene_id":"AY557712","genbank_protein_id":"45269315","gene_card_id":"PDX3","chromosome_location":"chromosome 2","locus":"YBR035C","synonyms":["PNP/PMP oxidase","PNPOx"],"enzyme_classes":["1.4.3.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" FMN binding"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH2 group of donors"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor"},{"category":"Function","description":" pyridoxamine-phosphate oxidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" vitamin metabolic process"},{"category":"Process","description":" water-soluble vitamin metabolic process"},{"category":"Process","description":" vitamin B6 metabolic process"},{"category":"Process","description":" pyridoxine metabolic process"},{"category":"Process","description":" pyridoxine biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PNPOx_C","identifier":"PF10590"},{"name":"Pyridox_oxidase","identifier":"PF01243"}],"pathways":[{"name":"Vitamin B6 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oxidase FMS1","uniprot_id":"P50264","uniprot_name":"FMS1_YEAST","enzyme":true,"transporter":false,"gene_name":"FMS1","num_residues":508,"molecular_weight":"57805.10156","theoretical_pi":"5.38","general_function":"Amino acid transport and metabolism","specific_function":"Involved in the production of beta-alanine, a precursor of pantothenic acid. Multicopy suppressor of fenpropimorph resistance","reactions":[{"id":1903,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1906,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1907,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2368,"direction":"\u003e","locations":null,"altext":"Spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2369,"direction":"\u003e","locations":null,"altext":"Spermidine + O(2) + H(2)O = putrescine + 3-aminopropanal + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2370,"direction":"\u003e","locations":null,"altext":"N(1)-acetylspermine + O(2) + H(2)O = spermidine + 3-acetamidopropanal + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2371,"direction":"\u003e","locations":null,"altext":"N(1)-acetylspermidine + O(2) + H(2)O = putrescine + 3-acetamidopropanal + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2372,"direction":"\u003e","locations":null,"altext":"N(8)-acetylspermidine + O(2) + H(2)O = 4-acetamidobutanal + trimethylenediamine + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3757,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006281","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1YY5","cellular_location":null,"genbank_gene_id":"X81848","genbank_protein_id":"1143556","gene_card_id":"FMS1","chromosome_location":"chromosome 13","locus":"YMR020W","synonyms":["Fenpropimorph resistance multicopy suppressor 1"],"enzyme_classes":["1.5.3.17"],"go_classes":[],"pfams":[{"name":"Amino_oxidase","identifier":"PF01593"}],"pathways":[{"name":"beta-Alanine metabolism","kegg_map_id":"00410"}],"gene_sequence":"ATGAATACAGTTTCACCAGCCAAAAAAAAGGTTATTATAATTGGTGCCGGTATTGCTGGGCTTAAAGCTGCATCTACGCTACACCAAAACGGTATTCAAGATTGTCTTGTTCTTGAGGCCAGAGATCGGGTCGGTGGTAGGTTGCAAACTGTCACAGGCTATCAAGGTCGGAAATATGATATAGGTGCTAGCTGGCACCATGATACGTTGACAAACCCTTTATTTTTGGAAGAGGCTCAACTGAGTTTGAATGATGGGAGAACGAGGTTTGTTTTTGATGACGATAATTTTATTTATATCGACGAAGAACGTGGAAGGGTAGACCATGACAAGGAACTGCTTCTTGAAATTGTGGACAATGAAATGAGCAAATTCGCAGAGTTAGAATTCCATCAACACTTAGGAGTTTCAGATTGCTCCTTTTTTCAATTAGTAATGAAATACTTACTACAAAGACGCCAATTTCTCACAAATGACCAAATAAGATATTTGCCACAACTCTGTCGATATCTGGAATTGTGGCACGGCTTAGATTGGAAGCTTTTGAGTGCCAAGGATACATACTTCGGTCACCAAGGAAGGAACGCCTTTGCTTTGAACTATGATTCTGTGGTTCAAAGAATTGCTCAAAGCTTTCCTCAAAATTGGTTAAAGCTAAGTTGTGAAGTGAAATCAATTACACGAGAACCTTCAAAAAATGTGACAGTGAACTGTGAAGATGGTACTGTGTACAATGCTGATTATGTTATTATTACAGTACCTCAAAGTGTATTGAATTTGTCTGTACAACCTGAAAAAAATTTACGGGGAAGAATAGAATTTCAACCACCCTTGAAACCAGTGATTCAAGATGCTTTTGACAAGATCCATTTTGGAGCGCTAGGTAAAGTAATTTTTGAGTTTGAAGAATGTTGTTGGTCGAACGAAAGTTCAAAAATTGTAACTTTGGCTAACTCTACCAATGAATTTGTCGAAATAGTACGTAATGCGGAAAATTTAGATGAATTAGACTCTATGCTAGAAAGGGAAGATTCTCAAAAGCATACGAGTGTTACTTGTTGGAGCCAGCCTTTATTTTTCGTAAATTTGTCAAAAAGCACAGGAGTAGCAAGCTTTATGATGTTGATGCAGGCACCGCTTACAAATCACATAGAATCCATTAGAGAAGATAAAGAGCGTCTTTTTAGTTTTTTCCAACCTGTGCTGAACAAGATTATGAAGTGTCTAGATTCTGAGGATGTCATCGACGGAATGAGGCCGATAGAAAACATTGCAAACGCTAATAAACCAGTCTTAAGAAACATCATCGTTAGCAACTGGACACGCGATCCTTACTCACGCGGTGCTTATTCGGCCTGTTTTCCAGGAGATGATCCAGTTGATATGGTTGTTGCAATGTCTAATGGTCAAGACTCCCGCATAAGATTTGCAGGCGAACATACTATCATGGACGGCGCCGGCTGTGCCTATGGTGCTTGGGAAAGCGGAAGACGGGAGGCGACTCGAATCTCTGACTTACTGAAATAG","protein_sequence":"MNTVSPAKKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGRKYDIGASWHHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERGRVDHDKELLLEIVDNEMSKFAELEFHQHLGVSDCSFFQLVMKYLLQRRQFLTNDQIRYLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRNAFALNYDSVVQRIAQSFPQNWLKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQSVLNLSVQPEKNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEECCWSNESSKIVTLANSTNEFVEIVRNAENLDELDSMLEREDSQKHTSVTCWSQPLFFVNLSKSTGVASFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKCLDSEDVIDGMRPIENIANANKPVLRNIIVSNWTRDPYSRGAYSACFPGDDPVDMVVAMSNGQDSRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLK"},{"created_at":"2011-05-24T21:41:52.000Z","updated_at":"2011-07-22T17:53:57.000Z","name":"Acyl-coenzyme A oxidase","uniprot_id":"P13711","uniprot_name":"ACOX_YEAST","enzyme":true,"transporter":false,"gene_name":"POX1","num_residues":748,"molecular_weight":"84041.39844","theoretical_pi":"8.7","general_function":"Involved in acyl-CoA dehydrogenase activity","specific_function":"Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2)","reactions":[{"id":1249,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1250,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1251,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1252,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1253,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1254,"direction":"\u003e","locations":"peroxisome","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2392,"direction":"\u003e","locations":"Peroxisome","altext":"Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Peroxisome","genbank_gene_id":"M27515","genbank_protein_id":"172217","gene_card_id":"POX1","chromosome_location":"chromosome 7","locus":"YGL205W","synonyms":["Acyl-CoA oxidase"],"enzyme_classes":["1.3.3.6"],"go_classes":[{"category":"Component","description":" microbody"},{"category":"Component","description":" peroxisome"},{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Function","description":" acyl-CoA dehydrogenase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" FAD or FADH2 binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor"},{"category":"Function","description":" acyl-CoA oxidase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Process","description":" fatty acid catabolic process"},{"category":"Process","description":" fatty acid beta-oxidation"},{"category":"Process","description":" monocarboxylic acid metabolic process"},{"category":"Process","description":" fatty acid metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"ACOX","identifier":"PF01756"},{"name":"Acyl-CoA_dh_M","identifier":"PF02770"}],"pathways":[{"name":"Fatty acid metabolism","kegg_map_id":"00071"},{"name":"alpha-Linolenic acid metabolism","kegg_map_id":"00592"},{"name":"Biosynthesis of unsaturated fatty acids","kegg_map_id":"01040"}],"gene_sequence":"ATGACGAGACGTACTACTATTAATCCCGATTCGGTGGTTCTGAATCCTCAAAAATTTATCCAGAAAGAAAGGGCGGATTCGAAAATCAAAGTTGACCAAGTTAACACATTTTTAGAGTCATCCCCGGAGAGGAGAACTCTGACGCACGCCTTAATAGACCAAATAGTGAATGATCCTATATTGAAAACTGATACGGACTATTACGATGCTAAAAAAATGCAAGAGAGAGAAATTACTGCCAAAAAAATAGCTAGGCTTGCTAGTTATATGGAGCACGATATCAAAACAGTGCGCAAACACTTTCGCGACACTGACCTGATGAAAGAGTTGCAAGCAAATGATCCAGACAAAGCTTCGCCTTTAACAAACAAAGACCTTTTTATATTCGATAAGAGATTGTCACTTGTAGCAAATATTGATCCTCAATTGGGTACGCGCGTGGGTGTACACTTGGGGCTATTTGGTAATTGTATCAAGGGCAATGGTACTGATGAGCAAATCCGGTATTGGTTGCAGGAGAGAGGTGCCACTTTGATGAAAGGTATATATGGCTGTTTTGCAATGACTGAGTTAGGACATGGTTCCAATGTTGCCCAGCTGCAGACTAGGGCTGTGTACGATAAGCAAAATGATACTTTTGTAATTGATACACCTGATCTAACTGCCACCAAATGGTGGATTGGTGGGGCTGCCCATTCTGCCACGCACGCTGCCGTGTACGCCAGATTGATCGTTGAAGGTAAAGACTACGGTGTAAAAACATTCGTTGTTCCTCTGAGAGACCCTTCGACTTTCCAACTGTTAGCTGGTGTTTCCATAGGGGATATTGGAGCGAAGATGGGTCGTGACGGTATTGATAATGGCTGGATCCAGTTCAGAAACGTAGTTATCCCTAGAGAATTTATGCTAAGTAGATTTACCAAAGTTGTCCGTTCTCCAGATGGTTCAGTCACCGTCAAAACTGAGCCACAATTGGATCAAATTTCTGGTTATAGTGCATTGTTAAGTGGTAGAGTTAACATGGTCATGGATTCATTTAGGTTTGGCTCCAAATTTGCTACTATTGCTGTACGTTACGCGGTTGGTCGTCAGCAATTCGCACCTAGAAAGGGATTGTCTGAAACACAATTAATCGACTATCCCCTTCACCAATATCGTGTTTTACCACAATTGTGTGTTCCATATTTGGTGTCACCTGTAGCTTTTAAGTTAATGGACAACTATTATTCCACTTTGGACGAGTTATACAACGCTTCCTCATCTGCATACAAAGCTGCTCTGGTTACCGTGAGTAAAAAGTTGAAGAATTTATTTATTGATAGCGCCACGTTGAAAGCCACCAATACTTGGTTAATTGCTACACTGATTGATGAGTTGAGACAGACTTGCGGAGGACATGGGTATTCACAGTATAACGGATTTGGTAAAGGCTATGACGACTGGGTGGTTCAGTGCACATGGGAGGGTGATAATAATGTTTTATCTTTAACTTCAGCAAAATCAATATTGAAAAAATTTATCGATTCAGCCACAAAGGGTAGATTTGACAACACACTGGATGTGGACTCATTCTCTTACTTAAAACCTCAGTACATAGGATCTGTGGTTTCTGGAGAAATAAAGAGTGGTTTAAAGGAGTTGGGTGATTATACTGAAATTTGGTCTATCACCTTAATCAAATTACTGGCACATATTGGTACTTTAGTTGAAAAATCAAGAAGTATTGATAGCGTTTCTAAGCTTTTAGTCTTAGTATCCAAATTTCATGCCTTGCGCTGCATGTTGAAAACCTATTACGACAAGTTAAACTCTCGTGATTCACATATTTCCGATGAAATTACAAAGGAATCTATGTGGAATGTTTATAAGTTATTTTCCTTGTATTTTATTGACAAGCATTCCGGAGAATTCCAACAATTCAAGATCTTCACTCCTGATCAGATCTCTAAAGTTGTGCAGCCACAACTATTGGCTCTTTTGCCAATTGTGAGGAAAGACTGTATAGGTCTGACAGACTCCTTTGAATTACCTGACGCGATGTTAAATTCTCCTATAGGTTACTTTGATGGCGATATCTATCACAATTACTTCAATGAAGTTTGCCGCAATAATCCAGTGGAGGCAGATGGGGCAGGGAAGCCTTCTTATCATGCGCTGTTGAGCAGCATGCTCGGTAGAGGTTTCGAATTTGACCAAAAGTTAGGTGGTGCAGCTAATGCGGAAATTTTATCGAAAATAAACAAGTGA","protein_sequence":"MTRRTTINPDSVVLNPQKFIQKERADSKIKVDQVNTFLESSPERRTLTHALIDQIVNDPILKTDTDYYDAKKMQEREITAKKIARLASYMEHDIKTVRKHFRDTDLMKELQANDPDKASPLTNKDLFIFDKRLSLVANIDPQLGTRVGVHLGLFGNCIKGNGTDEQIRYWLQERGATLMKGIYGCFAMTELGHGSNVAQLQTRAVYDKQNDTFVIDTPDLTATKWWIGGAAHSATHAAVYARLIVEGKDYGVKTFVVPLRDPSTFQLLAGVSIGDIGAKMGRDGIDNGWIQFRNVVIPREFMLSRFTKVVRSPDGSVTVKTEPQLDQISGYSALLSGRVNMVMDSFRFGSKFATIAVRYAVGRQQFAPRKGLSETQLIDYPLHQYRVLPQLCVPYLVSPVAFKLMDNYYSTLDELYNASSSAYKAALVTVSKKLKNLFIDSASLKATNTWLIATLIDELRQTCGGHGYSQYNGFGKGYDDWVVQCTWEGDNNVLSLTSAKSILKKFIDSATKGRFDNTLDVDSFSYLKPQYIGSVVSGEIKSGLKELGDYTEIWSITLIKLLAHIGTLVEKSRSIDSVSKLLVLVSKFHALRCMLKTYYDKLNSRDSHISDEITKESMWNVYKLFSLYFIDKHSGEFQQFKIFTPDQISKVVQPQLLALLPIVRKDCIGLTDSFELPDAMLNSPIGYFDGDIYHNYFNEVCRNNPVEADGAGKPSYHALLSSMLGRGFEFDQKLGGAANAEILSKINK"},{"created_at":"2011-05-26T16:48:31.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Glutathione peroxidase 1","uniprot_id":"P36014","uniprot_name":"GPX1_YEAST","enzyme":true,"transporter":false,"gene_name":"GPX1","num_residues":167,"molecular_weight":"19484.5","theoretical_pi":"8.57","general_function":"Involved in glutathione peroxidase activity","specific_function":"May constitute a glutathione peroxidase-like protective system against oxidative stresses","reactions":[{"id":1584,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2240,"direction":"\u003e","locations":"","altext":"2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":2241,"direction":"\u003e","locations":"Cytoplasm","altext":"2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + H2O","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY557895","genbank_protein_id":"45269681","gene_card_id":"GPX1","chromosome_location":"chromosome 11","locus":"YKL026C","synonyms":[],"enzyme_classes":["1.11.1.9","1.11.1.12"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" antioxidant activity"},{"category":"Function","description":" peroxidase activity"},{"category":"Function","description":" glutathione peroxidase activity"},{"category":"Process","description":" response to stimulus"},{"category":"Process","description":" response to stress"},{"category":"Process","description":" response to oxidative stress"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"GSHPx","identifier":"PF00255"}],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Arachidonic acid metabolism","kegg_map_id":"00590"}],"gene_sequence":"ATGCAAGAATTTTATTCTTTTTCACCAATAGATGAAAACGGAAATCCATTCCCCTTCAACTCCCTGCGTAACAAAGTGGTTTTGATAGTCAATGTAGCATCTCATTGTGCGTTCACACCTCAATACAAGGAATTAGAGTACTTGTACGAAAAATACAAATCACATGGTCTAGTGATTGTGGCCTTTCCCTGTGGTCAATTCGGAAATCAAGAGTTCGAGAAGGATAAAGAGATTAATAAGTTCTGTCAAGATAAATATGGTGTAACCTTCCCTATTCTACATAAGATCCGTTGCAACGGGCAAAAGCAAGATCCCGTCTACAAGTTCTTAAAGAATTCAGTAAGCGGGAAGTCTGGAATAAAAATGATAAAATGGAATTTTGAAAAGTTTGTGGTAGACCGAAATGGGAAGGTGGTTAAAAGGTTTTCATGCATGACTAGGCCACTAGAGCTTTGTCCAATAATCGAAGAATTACTGAATCAACCACCAGAAGAACAGATTTAA","protein_sequence":"MQEFYSFSPIDENGNPFPFNSLRNKVVLIVNVASHCAFTPQYKELEYLYEKYKSHGLVIVAFPCGQFGNQEFEKDKEINKFCQDKYGVTFPILHKIRCNGQKQDPVYKFLKNSVSGKSGIKMIKWNFEKFVVDRNGKVVKRFSCMTRPLELCPIIEELLNQPPEEQI"},{"created_at":"2011-05-26T17:41:21.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Protoporphyrinogen oxidase","uniprot_id":"P40012","uniprot_name":"PPOX_YEAST","enzyme":true,"transporter":false,"gene_name":"HEM14","num_residues":539,"molecular_weight":"59702.39844","theoretical_pi":"9.8","general_function":"Involved in oxygen-dependent protoporphyrinogen oxidase activity","specific_function":"Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX","reactions":[{"id":1913,"direction":"\u003e","locations":"mitochondrion","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2479,"direction":"\u003e","locations":"Mitochondrion inner membrane.","altext":"Protoporphyrinogen-IX + 3 O(2) = protoporphyrin-IX + 3 H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":14203,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006644","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion inner membrane.","genbank_gene_id":"U18778","genbank_protein_id":"603606","gene_card_id":"HEM14","chromosome_location":"chromosome 5","locus":"YER014W","synonyms":["PPO"],"enzyme_classes":["1.3.3.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" oxygen-dependent protoporphyrinogen oxidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" tetrapyrrole metabolic process"},{"category":"Process","description":" porphyrin metabolic process"},{"category":"Process","description":" porphyrin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"}],"pfams":[],"pathways":[{"name":"Porphyrin and chlorophyll metabolism","kegg_map_id":"00860"},{"name":"Porphyrin Metabolism","kegg_map_id":null}],"gene_sequence":"ATGTTATTACCATTAACAAAGCTAAAACCGAGAGCAAAAGTTGCTGTTGTAGGGGGTGGCGTTTCTGGACTATGTTTTACTTATTTTTTAAGCAAGTTGAGACCGGATGTTGAAATCACACTGTTCGAATCGCAGAACAGAACTGGGGGTTGGATATATTCTTGTAACACAAGAGATATGAGTGGGAACCCAATTATGTTGGAGAAGGGACCCAGAACATTGAGGGGCGTATCAGACGGGACCGTTCTGATTATGGATACCCTTAAAGACTTGGGCAAGGAAGCAGTTATTCAAAGCATTGATAAAGGTTGCATTGCAGACAAAAAGTTTCTACTAGACCCCAGTGATAAACTCGTGCAGGTTCCTAATTCGATATCTACAACAGTAAAATTTCTGCTGAATCCGTTGGGAAAAGGACTCATCACGGGTATGATGGGAGAATGGTTCAGAAAAAAATCTCCACATCCTGGCCAAGACGAAAGTGTCGAATCCATTTGTGACAGAAGGTTTGGGAATAACTACATATCAAACAATATGATCAGTGCCTTACTAAGAGGTATCTATGGGGATGACGTTTCCCTATTAAGTGCCAAGAGAACGTTTAAGAAAATATACTACAATGAACTAAAGCACGGATCTAACACACAAGCTATGATTGATAATATGCGCGGAAAGTCAAGAAGTAAAAAAACTGAGAACCTGCACCAATCTTTAACTGGCTGCCTTAACGACTACTCAAATGCGTTTGGAAAAGACAGGTCAAAGTTATTAGACTTATCCAACACGCTAAAGAAATATCCCATGTTGGGTCTTGCTGGGGGACTAGAAACGTTTCCCAAGATAGTCAGAAATGCTTTGAACGAATTTAAAAACGTCAAAATAGTTACTGGGAACCCGGTTACGCAAATAATGAAACGCCCTGCTAACGAAACGACAATCGGATTGAAAGCGAAATCTGGCGACCAATACGAAACATTTGACCATTTAAGACTTACGATAACACCTCCCAAAATCGCTAAATTGCTACCGAAGGATCAAAATTCATTATCCAAGTTATTAGATGAGATACAATCAAACACAATAATTTTAGTTAATTATTATTTGCCAAACAAAGATGTAATAGATGCCGATCTACAAGGCTTTGGATACTTGGTTCCCAAATCCAATAAGAATCCAGGGAAATTGCTTGGTGTAATTTTCGATTCTGTTATCGAAAGGAATTTCAAACCACTTTTTGACAAACTCTCCACAAACCCAAACGCCCTCAACAAATATACAAAAGTGACTGCGATGATAGGAGGTTGTATGCTCAATGAACACGGTGTTCCTGTAGTGCCATCCAGGGAGGTAACCATTAATGCAGTCAAAGATGCGCTGAACAACCACCTCGGCATCAGTAACAAGGATCTGGAAGCTGGTCAGTGGGAATTCACTATCGCCGATAGATGTCTGCCAAGATTTCATGTAGGTTATGACGCATGGCAAGAAAGAGCTGAAAGGAAGTTGCAAGAATCTTACGGCCAAACAGTTTCTGTGGGGGGAATGGGATTTTCTAGAAGTCCCGGTGTCCCTGACGTTATTGTAGACGGCTTTAACGACGCCTTACAGCTAAGCAAATAA","protein_sequence":"MLLPLTKLKPRAKVAVVGGGVSGLCFTYFLSKLRPDVEITLFESQNRTGGWIYSCNTRDMSGNPIMLEKGPRTLRGVSDGTVLIMDTLKDLGKEAVIQSIDKGCIADKKFLLDPSDKLVQVPNSISTTVKFLLNPLGKGLITGMMGEWFRKKSPHPGQDESVESICDRRFGNNYISNNMISALLRGIYGDDVSLLSAKRTFKKIYYNELKHGSNTQAMIDNMRGKSRSKKTENLHQSLTGCLNDYSNAFGKDRSKLLDLSNTLKKYPMLGLAGGLETFPKIVRNALNEFKNVKIVTGNPVTQIMKRPANETTIGLKAKSGDQYETFDHLRLTITPPKIAKLLPKDQNSLSKLLDEIQSNTIILVNYYLPNKDVIDADLQGFGYLVPKSNKNPGKLLGVIFDSVIERNFKPLFDKLSTNPNALNKYTKVTAMIGGCMLNEHGVPVVPSREVTINAVKDALNNHLGISNKDLEAGQWEFTIADRCLPRFHVGYDAWQERAERKLQESYGQTVSVGGMGFSRSPGVPDVIVDGFNDALQLSK"},{"created_at":"2011-05-26T17:55:45.000Z","updated_at":"2011-07-22T17:54:31.000Z","name":"Coproporphyrinogen-III oxidase","uniprot_id":"P11353","uniprot_name":"HEM6_YEAST","enzyme":true,"transporter":false,"gene_name":"HEM13","num_residues":328,"molecular_weight":"37711.30078","theoretical_pi":"6.8","general_function":"Involved in coproporphyrinogen oxidase activity","specific_function":"Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III","reactions":[{"id":1414,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2496,"direction":"\u003e","locations":"Cytoplasm","altext":"Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1TLB","cellular_location":"Cytoplasm","genbank_gene_id":"AY557656","genbank_protein_id":"45269205","gene_card_id":"HEM13","chromosome_location":"chromosome 4","locus":"YDR044W","synonyms":["COX","Coprogen oxidase","Coproporphyrinogenase"],"enzyme_classes":["1.3.3.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" coproporphyrinogen oxidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" tetrapyrrole metabolic process"},{"category":"Process","description":" porphyrin metabolic process"},{"category":"Process","description":" porphyrin biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" nitrogen compound metabolic process"}],"pfams":[{"name":"Coprogen_oxidas","identifier":"PF01218"}],"pathways":[{"name":"Porphyrin and chlorophyll 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growth protein 1","uniprot_id":"P21375","uniprot_name":"OSM1_YEAST","enzyme":true,"transporter":false,"gene_name":"OSM1","num_residues":501,"molecular_weight":"55064.80078","theoretical_pi":"9.51","general_function":"Involved in electron carrier activity","specific_function":"Could be a fumarate reductase","reactions":[{"id":1555,"direction":"\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1556,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":3732,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006258","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm (Probable)","genbank_gene_id":"L26347","genbank_protein_id":"695798","gene_card_id":"OSM1","chromosome_location":"chromosome 10","locus":"YJR051W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" succinate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"FAD_binding_2","identifier":"PF00890"}],"pathways":[],"gene_sequence":"ATGATTAGATCTGTGAGAAGGGTTTTCATTTACGTCTCAATATTCGTATTGATAATAGTTTTGAAAAGAACATTAAGTGGCACAGATCAAACGTCAATGAAACAACCAGTGGTGGTCATTGGCTCTGGTTTGGCAGGCTTAACCACAAGTAATCGTCTCATTAGTAAATACAGAATTCCTGTTGTGCTTTTGGATAAGGCGGCTTCTATTGGTGGGAATTCTATAAAGGCTTCTAGTGGTATTAATGGTGCTCACACAGACACTCAACAAAATTTAAAGGTAATGGACACTCCCGAATTGTTTTTGAAAGATACTTTGCATTCGGCTAAAGGCAGAGGGGTTCCATCACTGATGGATAAGTTGACTAAGGAATCCAAGAGTGCTATCAGGTGGTTGCAAACAGAATTCGATTTGAAATTAGACCTCCTTGCGCAATTGGGCGGTCACTCTGTTCCAAGGACCCATAGATCTTCTGGCAAATTACCACCAGGTTTTGAAATCGTGCAAGCGTTATCAAAAAAACTAAAGGATATCTCTTCCAAAGATTCCAATCTCGTGCAGATTATGCTAAACAGTGAAGTAGTGGATATCGAGCTTGATAATCAAGGTCATGTTACTGGTGTAGTATATATGGACGAGAACGGAAACCGTAAAATCATGAAGTCACACCATGTCGTGTTTTGCTCAGGTGGATTTGGTTACTCTAAGGAAATGTTGAAAGAGTACTCACCAAATTTGATTCACTTGCCAACTACTAATGGCAAACAGACTACAGGTGATGGTCAAAAAATCCTTTCAAAGTTGGGTGCCGAATTGATTGATATGGATCAAGTGCAGGTACACCCTACCGGCTTCATTGATCCAAATGACCGTGAAAATAACTGGAAGTTTTTGGCTGCAGAGGCATTGAGGGGTTTAGGCGGCATCTTATTGCATCCCACCACTGGAAGAAGGTTTACAAATGAATTGAGCACCAGAGATACAGTAACCATGGAAATACAGTCTAAATGTCCGAAAAATGATAATAGAGCACTTTTGGTAATGAGCGACAAAGTCTACGAGAACTATACGAATAACATAAACTTTTATATGTCCAAAAACTTAATCAAAAAAGTGTCAATCAACGATCTGATCCGACAATATGACCTACAAACTACAGCTTCTGAACTGGTAACTGAACTGAAGAGCTATTCCGATGTTAATACTAAGGATACGTTTGATAGGCCATTGATTATCAATGCCTTTGATAAAGATATTTCGACTGAATCAACTGTTTATGTTGGGGAAGTTACACCAGTTGTTCATTTCACAATGGGTGGTGTGAAAATTAATGAGAAATCTCAGGTAATTAAGAAAAATTCGGAAAGCGTTCTATCTAATGGGATATTTGCTGCTGGTGAAGTTTCGGGTGGTGTTCATGGAGCCAACAGATTGGGTGGATCTAGTTTGTTAGAGTGTGTTGTCTTTGGAAAGACAGCTGCGGATAACATAGCAAAATTGTACTGA","protein_sequence":"MIRSVRRVFIYVSIFVLIIVLKRTLSGTDQTSMKQPVVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMDTPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTEFDLKLDLLAQLGGHSVPRTHRSSGKLPPGFEIVQALSKKLKDISSKDSNLVQIMLNSEVVDIELDNQGHVTGVVYMDENGNRKIMKSHHVVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTGDGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRFTNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSINDLIRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIINAFDKDISTESTVYVGEVTPVVHFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVSGGVHGANRLGGSSLLECVVFGKTAADNIAKLY"},{"created_at":"2011-05-27T02:58:20.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Monothiol glutaredoxin-5, mitochondrial","uniprot_id":"Q02784","uniprot_name":"GLRX5_YEAST","enzyme":true,"transporter":false,"gene_name":"GRX5","num_residues":150,"molecular_weight":"16931.30078","theoretical_pi":"4.54","general_function":"Involved in electron carrier activity","specific_function":"Monothiol glutaredoxin involved in iron-sulfur biogenesis. Required for normal iron homeostasis. Protects cells against oxidative damage due to reactive oxygen species","reactions":[{"id":1584,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"U39205","genbank_protein_id":"1079683","gene_card_id":"GRX5","chromosome_location":"chromosome 16","locus":"YPL059W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" disulfide oxidoreductase activity"},{"category":"Function","description":" protein disulfide oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" cell redox homeostasis"}],"pfams":[{"name":"Glutaredoxin","identifier":"PF00462"}],"pathways":[],"gene_sequence":"ATGTTTCTCCCAAAATTCAATCCCATAAGGTCATTTTCCCCCATCCTCCGGGCTAAGACTCTTCTTCGTTACCAAAATCGGATGTATTTGAGCACAGAGATAAGAAAAGCTATTGAAGATGCCATCGAATCGGCTCCAGTGGTTCTTTTCATGAAAGGTACTCCTGAATTTCCCAAGTGTGGATTTTCAAGAGCAACCATTGGATTATTAGGAAATCAAGGCGTTGACCCGGCCAAATTTGCGGCTTATAATGTTTTAGAAGACCCAGAGCTACGTGAAGGTATCAAAGAGTTTTCAGAATGGCCAACTATTCCACAGTTATATGTAAACAAAGAATTCATTGGTGGATGTGATGTTATTACAAGTATGGCACGCTCTGGTGAATTGGCCGATTTGCTAGAAGAGGCACAGGCATTGGTACCTGAAGAAGAAGAAGAAACCAAAGATCGTTGA","protein_sequence":"MFLPKFNPIRSFSPILRAKTLLRYQNRMYLSTEIRKAIEDAIESAPVVLFMKGTPEFPKCGFSRATIGLLGNQGVDPAKFAAYNVLEDPELREGIKEFSEWPTIPQLYVNKEFIGGCDVITSMARSGELADLLEEAQALVPEEEEETKDR"},{"created_at":"2011-05-27T02:58:52.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Peroxiredoxin HYR1","uniprot_id":"P40581","uniprot_name":"GPX3_YEAST","enzyme":true,"transporter":false,"gene_name":"HYR1","num_residues":163,"molecular_weight":"18641.40039","theoretical_pi":"8.42","general_function":"Involved in glutathione peroxidase activity","specific_function":"Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator YAP1, which is involved in transcription activation of genes of the oxidative stress response pathway. May also play a direct role in hydroperoxide scavenging, being the most active of three closely related S.cerevisiae peroxiredoxins (GPX1, GPX2, and HYP1/GPX3) with respect to peroxide and lipid hydroperoxide reduction. The three enzymes are not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, HYP1 is directly oxidized at Cys-36 to form a cysteine sulfenic acid (-SOH). Cys-36-SOH then forms either an intramolecular disulfide bond (Cys-36 with Cys-82) or a transient, intermolecular disulfide bond with 'Cys-598' of YAP1, which is further resolved into a YAP1 intramolecular disulfide bond ('Cys-303' with 'Cys-598') and a reduced Cys-36 in HYP1/GPX3","reactions":[{"id":1584,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2701,"direction":"\u003e","locations":"Nucleus. Chromosome, telomere (Potential);Cytoplasm;Mitochondrion","altext":"2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.","export":false,"pw_reaction_id":null,"source":null},{"id":2241,"direction":"\u003e","locations":"Cytoplasm","altext":"2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + H2O","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U22446","genbank_protein_id":"727367","gene_card_id":"HYR1","chromosome_location":"chromosome 9","locus":"YIR037W","synonyms":["Glutathione peroxidase 3","Hydrogen peroxide resistance protein 1","Oxidant receptor peroxidase 1","Phospholipid hydroperoxide glutathione peroxidase 3","PHGPx3"],"enzyme_classes":["1.11.1.15","1.11.1.12"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" antioxidant activity"},{"category":"Function","description":" peroxidase activity"},{"category":"Function","description":" glutathione peroxidase activity"},{"category":"Process","description":" response to stimulus"},{"category":"Process","description":" response to stress"},{"category":"Process","description":" response to oxidative stress"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"}],"pfams":[{"name":"GSHPx","identifier":"PF00255"}],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGTCAGAATTCTATAAGCTAGCACCTGTTGACAAGAAAGGCCAACCATTCCCCTTCGACCAATTAAAGGGAAAAGTGGTGCTTATCGTTAATGTTGCCTCCAAATGTGGATTCACTCCTCAATACAAAGAACTAGAGGCCTTGTACAAACGTTATAAGGACGAAGGATTTACCATCATCGGGTTCCCATGCAACCAGTTTGGCCACCAAGAACCTGGCTCTGATGAAGAAATTGCCCAGTTCTGCCAACTGAACTATGGCGTGACTTTCCCCATTATGAAAAAAATTGACGTTAATGGTGGCAATGAGGACCCTGTTTACAAGTTTTTGAAGAGCCAAAAATCCGGTATGTTGGGCTTGAGAGGTATCAAATGGAATTTTGAAAAATTCTTAGTCGATAAAAAGGGTAAAGTGTACGAAAGATACTCTTCACTAACCAAACCTTCTTCGTTGTCCGAAACCATCGAAGAACTTTTGAAAGAGGTGGAATAG","protein_sequence":"MSEFYKLAPVDKKGQPFPFDQLKGKVVLIVNVASKCGFTPQYKELEALYKRYKDEGFTIIGFPCNQFGHQEPGSDEEIAQFCQLNYGVTFPIMKKIDVNGGNEDPVYKFLKSQKSGMLGLRGIKWNFEKFLVDKKGKVYERYSSLTKPSSLSETIEELLKEVE"},{"created_at":"2011-05-27T03:00:10.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Glutaredoxin-2, mitochondrial","uniprot_id":"P17695","uniprot_name":"GLRX2_YEAST","enzyme":true,"transporter":false,"gene_name":"GRX2","num_residues":143,"molecular_weight":"15861.2998","theoretical_pi":"7.41","general_function":"Involved in electron carrier activity","specific_function":"Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage","reactions":[{"id":1584,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Mitochondrion.","genbank_gene_id":"AY692896","genbank_protein_id":"51013243","gene_card_id":"GRX2","chromosome_location":"chromosome 4","locus":"YDR513W","synonyms":["Glutathione-dependent oxidoreductase 2","Thioltransferase"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" disulfide oxidoreductase activity"},{"category":"Function","description":" protein disulfide oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" cell redox homeostasis"}],"pfams":[{"name":"Glutaredoxin","identifier":"PF00462"}],"pathways":[],"gene_sequence":"ATGGAGACCAATTTTTCCTTCGACTCGAATTTAATTGTTATTATCATTATCACGTTGTTTGCCACAAGAATTATTGCTAAAAGATTTTTATCTACTCCAAAAATGGTATCCCAGGAAACAGTTGCTCACGTAAAGGATCTGATTGGCCAAAAGGAAGTGTTTGTTGCAGCAAAGACATACTGCCCTTACTGTAAAGCTACTTTGTCTACCCTCTTCCAAGAATTGAACGTTCCCAAATCCAAGGCCCTTGTGTTGGAATTAGATGAAATGAGCAATGGCTCAGAGATTCAAGACGCTTTAGAAGAAATCTCGGGCCAAAAAACTGTACCTAACGTATACATCAATGGCAAGCACATTGGTGGTAACAGCGATTTGGAAACTTTGAAGAAAAATGGCAAGTTAGCTGAAATATTGAAGCCGGTATTTCAATAG","protein_sequence":"METNFSFDSNLIVIIIITLFATRIIAKRFLSTPKMVSQETVAHVKDLIGQKEVFVAAKTYCPYCKATLSTLFQELNVPKSKALVLELDEMSNGSEIQDALEEISGQKTVPNVYINGKHIGGNSDLETLKKNGKLAEILKPVFQ"},{"created_at":"2011-05-27T03:05:54.000Z","updated_at":"2011-05-27T15:01:19.000Z","name":"Glutaredoxin-1","uniprot_id":"P25373","uniprot_name":"GLRX1_YEAST","enzyme":true,"transporter":false,"gene_name":"GRX1","num_residues":110,"molecular_weight":"12380.09961","theoretical_pi":"4.72","general_function":"Involved in electron carrier activity","specific_function":"Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage","reactions":[{"id":1584,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X59720","genbank_protein_id":"5328","gene_card_id":"GRX1","chromosome_location":"chromosome 3","locus":"YCL035C","synonyms":["Glutathione-dependent oxidoreductase 1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" disulfide oxidoreductase activity"},{"category":"Function","description":" protein disulfide oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" cell redox homeostasis"}],"pfams":[{"name":"Glutaredoxin","identifier":"PF00462"}],"pathways":[],"gene_sequence":"ATGGTATCTCAAGAAACTATCAAGCACGTCAAGGACCTTATTGCAGAAAACGAGATCTTCGTCGCATCCAAAACGTACTGTCCATACTGCCATGCAGCCCTAAACACGCTTTTTGAAAAGTTAAAGGTTCCCAGGTCCAAAGTTCTGGTTTTGCAATTGAATGACATGAAGGAAGGCGCAGACATTCAGGCTGCGTTATATGAGATTAATGGCCAAAGAACCGTGCCAAACATCTATATTAATGGTAAACATATTGGAGGCAACGACGACTTGCAGGAATTGAGGGAGACTGGTGAATTGGAGGAATTGTTAGAACCTATTCTTGCAAATTAA","protein_sequence":"MVSQETIKHVKDLIAENEIFVASKTYCPYCHAALNTLFEKLKVPRSKVLVLQLNDMKEGADIQAALYEINGQRTVPNIYINGKHIGGNDDLQELRETGELEELLEPILAN"},{"created_at":"2011-05-27T03:51:12.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Thioredoxin-2","uniprot_id":"P22803","uniprot_name":"TRX2_YEAST","enzyme":true,"transporter":false,"gene_name":"TRX2","num_residues":104,"molecular_weight":"11203.7998","theoretical_pi":"4.54","general_function":"Involved in electron carrier activity","specific_function":"Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl- hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER- derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism. Through its capacity to inactivate the stress response transcription factor YAP1 and its regulator the hydroperoxide stress sensor HYR1, it is involved in feedback regulation of stress response gene expression upon oxidative stress","reactions":[{"id":1949,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1950,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1951,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1952,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus","genbank_gene_id":"AY557817","genbank_protein_id":"45269525","gene_card_id":"TRX2","chromosome_location":"chromosome 7","locus":"YGR209C","synonyms":["Thioredoxin II","TR-II","Thioredoxin-1"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" disulfide oxidoreductase activity"},{"category":"Function","description":" protein disulfide oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" cell redox homeostasis"},{"category":"Process","description":" organic ether metabolic process"},{"category":"Process","description":" glycerol ether metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Thioredoxin","identifier":"PF00085"}],"pathways":[],"gene_sequence":"ATGGTCACTCAATTAAAATCCGCTTCTGAATACGACAGTGCTTTAGCATCTGGCGACAAGTTAGTCGTTGTTGACTTTTTTGCCACATGGTGTGGGCCATGTAAAATGATTGCACCAATGATTGAAAAGTTTGCAGAACAATATTCTGACGCTGCTTTTTACAAGTTGGATGTTGATGAAGTCTCAGATGTTGCTCAAAAAGCTGAAGTTTCTTCCATGCCTACCCTAATCTTCTACAAGGGCGGTAAGGAGGTTACCAGAGTCGTCGGTGCCAACCCAGCTGCTATCAAGCAAGCTATTGCTTCCAACGTATAG","protein_sequence":"MVTQLKSASEYDSALASGDKLVVVDFFATWCGPCKMIAPMIEKFAEQYSDAAFYKLDVDEVSDVAQKAEVSSMPTLIFYKGGKEVTRVVGANPAAIKQAIASNV"},{"created_at":"2011-05-27T03:51:46.000Z","updated_at":"2011-05-27T15:01:21.000Z","name":"Thioredoxin-1","uniprot_id":"P22217","uniprot_name":"TRX1_YEAST","enzyme":true,"transporter":false,"gene_name":"TRX1","num_residues":103,"molecular_weight":"11234.90039","theoretical_pi":"4.54","general_function":"Involved in electron carrier activity","specific_function":"Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl- hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER- derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism","reactions":[{"id":1949,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1950,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1951,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1952,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus","genbank_gene_id":"AY558203","genbank_protein_id":"45270296","gene_card_id":"TRX1","chromosome_location":"chromosome 12","locus":"YLR043C","synonyms":["Thioredoxin I","TR-I","Thioredoxin-2"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" electron carrier activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" disulfide oxidoreductase activity"},{"category":"Function","description":" protein disulfide oxidoreductase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" cellular process"},{"category":"Process","description":" cellular homeostasis"},{"category":"Process","description":" cell redox homeostasis"},{"category":"Process","description":" organic ether metabolic process"},{"category":"Process","description":" glycerol ether metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Thioredoxin","identifier":"PF00085"}],"pathways":[],"gene_sequence":"ATGGTTACTCAATTCAAAACTGCCAGCGAATTCGACTCTGCAATTGCTCAAGACAAGCTAGTTGTCGTAGATTTCTACGCCACTTGGTGCGGTCCATGTAAAATGATTGCTCCAATGATTGAAAAATTCTCTGAACAATACCCACAAGCTGATTTCTATAAATTGGATGTCGATGAATTGGGTGATGTTGCACAAAAGAATGAAGTTTCCGCTATGCCAACTTTGCTTCTATTCAAGAACGGTAAGGAAGTTGCAAAGGTTGTTGGTGCCAACCCAGCGGCTATTAAGCAAGCCATTGCTGCTAATGCTTAA","protein_sequence":"MVTQFKTASEFDSAIAQDKLVVVDFYATWCGPCKMIAPMIEKFSEQYPQADFYKLDVDELGDVAQKNEVSAMPTLLLFKNGKEVAKVVGANPAAIKQAIAANA"},{"created_at":"2011-05-27T07:08:16.000Z","updated_at":"2011-05-29T05:06:45.000Z","name":"Superoxide dismutase [Cu-Zn]","uniprot_id":"P00445","uniprot_name":"SODC_YEAST","enzyme":true,"transporter":false,"gene_name":"SOD1","num_residues":154,"molecular_weight":"15854.59961","theoretical_pi":"5.91","general_function":"Involved in metal ion binding","specific_function":"Destroys radicals which are normally produced within the cells and which are toxic to biological systems","reactions":[{"id":2801,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm. Mitochondrion intermembrane space.","altext":"2 superoxide + 2 H(+) = O(2) + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1F1G","cellular_location":"Cytoplasm. Mitochondrion intermembrane space.","genbank_gene_id":"AY558073","genbank_protein_id":"45270036","gene_card_id":"SOD1","chromosome_location":"chromosome 10","locus":"YJR104C","synonyms":[],"enzyme_classes":["1.15.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" oxygen and reactive oxygen species metabolic process"},{"category":"Process","description":" superoxide metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"Sod_Cu","identifier":"PF00080"}],"pathways":[],"gene_sequence":"ATGGTTCAAGCAGTCGCAGTGTTAAAGGGTGATGCCGGTGTCTCTGGTGTTGTCAAGTTCGAACAGGCTTCCGAATCCGAGCCAACCACTGTCTCTTACGAGATCGCTGGTAACAGTCCTAACGCAGAACGTGGGTTCCACATTCATGAGTTTGGAGATGCCACCAATGGTTGTGTCTCTGCTGGTCCTCACTTCAATCCTTTCAAGAAGACACATGGTGCTCCAACTGACGAAGTCAGACATGTCGGTGACATGGGTAACGTAAAGACGGACGAAAATGGTGTGGCCAAGGGCTCCTTCAAGGACTCTTTGATCAAGCTTATCGGTCCTACCTCCGTTGTAGGCAGAAGCGTCGTTATCCACGCCGGCCAAGATGACTTAGGTAAGGGTGACACTGAAGAATCTTTGAAGACTGGTAATGCCGGTCCAAGACCAGCCTGTGGTGTCATTGGTCTAACCAACTAA","protein_sequence":"MVQAVAVLKGDAGVSGVVKFEQASESEPTTVSYEIAGNSPNAERGFHIHEFGDATNGCVSAGPHFNPFKKTHGAPTDEVRHVGDMGNVKTDENGVAKGSFKDSLIKLIGPTSVVGRSVVIHAGQDDLGKGDTEESLKTGNAGPRPACGVIGLTN"},{"created_at":"2011-05-27T07:09:13.000Z","updated_at":"2011-05-29T05:06:45.000Z","name":"Superoxide dismutase [Mn], mitochondrial","uniprot_id":"P00447","uniprot_name":"SODM_YEAST","enzyme":true,"transporter":false,"gene_name":"SOD2","num_residues":233,"molecular_weight":"25774.09961","theoretical_pi":"8.87","general_function":"Involved in superoxide dismutase activity","specific_function":"Destroys radicals which are normally produced within the cells and which are toxic to biological systems","reactions":[{"id":2801,"direction":"\u003e","locations":"Mitochondrion matrix;Cytoplasm. Mitochondrion intermembrane space.","altext":"2 superoxide + 2 H(+) = O(2) + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY557821","genbank_protein_id":"45269533","gene_card_id":"SOD2","chromosome_location":"chromosome 8","locus":"YHR008C","synonyms":[],"enzyme_classes":["1.15.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" antioxidant activity"},{"category":"Function","description":" superoxide dismutase activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" oxygen and reactive oxygen species metabolic process"},{"category":"Process","description":" superoxide metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"}],"pfams":[{"name":"Sod_Fe_C","identifier":"PF02777"},{"name":"Sod_Fe_N","identifier":"PF00081"}],"pathways":[],"gene_sequence":"ATGTTCGCGAAAACAGCAGCTGCTAATTTAACCAAGAAGGGTGGTTTGTCATTGCTCTCCACCACAGCAAGGAGAACCAAAGTCACCTTGCCAGACTTGAAGTGGGACTTCGGTGCATTGGAACCTTATATCTCCGGTCAAATCAACGAATTGCATTACACCAAGCACCATCAAACTTATGTGAACGGATTCAACACTGCTGTTGACCAATTCCAAGAACTCTCAGATCTTCTGGCCAAGGAGCCCTCTCCCGCAAACGCAAGAAAAATGATTGCTATCCAACAAAACATCAAGTTCCATGGCGGTGGTTTCACAAACCACTGTCTATTCTGGGAAAACCTGGCTCCAGAGTCGCAGGGCGGTGGTGAACCACCCACCGGCGCTTTGGCAAAGGCAATCGACGAGCAGTTTGGCAGTCTGGACGAGCTGATTAAGTTGACCAACACAAAGCTAGCAGGCGTGCAGGGCTCCGGATGGGCCTTCATTGTGAAAAACCTCTCTAATGGAGGCAAGCTGGACGTTGTTCAAACCTACAACCAGGATACCGTCACAGGCCCACTAGTTCCTCTAGTTGCCATTGACGCCTGGGAACACGCCTACTACTTGCAGTACCAAAACAAGAAAGCCGACTACTTCAAAGCCATTTGGAATGTGGTCAACTGGAAAGAAGCATCCAGAAGATTCGATGCTGGCAAGATCTGA","protein_sequence":"MFAKTAAANLTKKGGLSLLSTTARRTKVTLPDLKWDFGALEPYISGQINELHYTKHHQTYVNGFNTAVDQFQELSDLLAKEPSPANARKMIAIQQNIKFHGGGFTNHCLFWENLAPESQGGGEPPTGALAKAIDEQFGSLDELIKLTNTKLAGVQGSGWAFIVKNLSNGGKLDVVQTYNQDTVTGPLVPLVAIDAWEHAYYLQYQNKKADYFKAIWNVVNWKEASRRFDAGKI"},{"created_at":"2011-05-27T07:14:15.000Z","updated_at":"2011-07-22T17:54:36.000Z","name":"Dihydroorotate dehydrogenase","uniprot_id":"P28272","uniprot_name":"PYRD_YEAST","enzyme":true,"transporter":false,"gene_name":"URA1","num_residues":314,"molecular_weight":"34800.60156","theoretical_pi":"5.85","general_function":"Involved in catalytic activity","specific_function":"In the de novo pyrimidine biosynthesic pathway, catalyzes the stereospecific oxidation of (S)-dihydroorotate to orotate and the reduction of fumarate to succinate. Does not use oxaloacetate and NAD or NADP as electron acceptors","reactions":[{"id":1453,"direction":"\u003e","locations":"mitochondrion;mitochondrial membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1454,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1554,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2803,"direction":"\u003e","locations":"Cytoplasm","altext":"(S)-dihydroorotate + O(2) = orotate + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2804,"direction":"\u003e","locations":"Cytoplasm","altext":"(S)-dihydroorotate + a quinone = orotate + a quinol","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AJ585637","genbank_protein_id":"45719878","gene_card_id":"URA1","chromosome_location":"chromosome 11","locus":"YKL216W","synonyms":["DHOD","DHODase","DHOdehase","Dihydroorotate oxidase"],"enzyme_classes":["1.3.3.1","1.3.5.2"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors"},{"category":"Function","description":" dihydroorotate oxidase activity"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as 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The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. 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The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. 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all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide","reactions":[{"id":1368,"direction":"\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2820,"direction":"\u003e","locations":"Peroxisome;Cytoplasm","altext":"2 H(2)O(2) = O(2) + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X04625","genbank_protein_id":"3608","gene_card_id":"CTT1","chromosome_location":"chromosome 7","locus":"YGR088W","synonyms":[],"enzyme_classes":["1.11.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion 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1","kegg_map_id":null}],"gene_sequence":"ATGAACGTGTTCGGTAAAAAAGAAGAAAAGCAAGAAAAAGTTTACTCTCTACAAAACGGTTTTCCGTACTCTCATCACCCATACGCTTCTCAATACTCAAGACCAGACGGCCCTATCTTACTGCAAGACTTCCATCTGCTGGAAAATATCGCAAGTTTCGATAGAGAAAGAGTTCCGGAGCGTGTAGTCCATGCCAAAGGTGGTGGTTGTAGACTGGAGTTCGAACTAACAGATTCTTTGAGTGATATTACATACGCCGCTCCATACCAGAATGTGGGTTACAAATGTCCTGGTCTTGTTCGTTTTTCCACCGTTGGTGGTGAAAGTGGTACACCAGACACTGCAAGAGACCCAAGAGGTGTTTCTTTTAAATTCTATACCGAGTGGGGGAACCATGACTGGGTCTTCAACAATACTCCCGTCTTCTTCCTCAGAGACGCTATTAAGTTTCCCGTATTTATTCATTCGCAAAAGAGAGACCCTCAGTCTCATCTGAATCAGTTTCAGGACACTACCATATACTGGGATTATCTAACATTGAATCCGGAATCAATCCATCAAATAACTTACATGTTTGGTGATAGAGGTACTCCTGCTTCGTGGGCTAGTATGAACGCGTACTCTGGTCATTCCTTCATCATGGTCAACAAAGAAGGTAAGGACACATATGTGCAATTCCACGTCTTGTCGGATACTGGTTTTGAAACCTTGACTGGAGATAAGGCTGCTGAACTGTCAGGCTCCCACCCTGATTATAATCAGGCAAAGCTGTTCACTCAATTGCAAAATGGCGAAAAGCCAAAATTTAACTGTTATGTGCAAACAATGACACCCGAACAAGCAACTAAGTTCAGGTATTCGGTAAATGACCTAACGAAAATATGGCCACACAAGGAATTCCCTTTGAGAAAATTTGGTACCATCACCCTAACGGAGAATGTTGACAATTATTTCCAAGAAATTGAACAAGTTGCATTCAGTCCAACGAACACTTGTATCCCAGGTATTAAGCCTTCTAATGATTCCGTTCTACAAGCCAGACTTTTCTCCTATCCAGACACTCAACGTCATAGATTGGGAGCCAACTATCAGCAATTGCCCGTCAACAGACCAAGAAACTTGGGATGTCCATACTCCAAAGGTGATTCCCAATACACTGCCGAACAGTGTCCATTTAAAGCAGTGAACTTCCAAAGGGACGGCCCAATGAGTTACTACAATTTCGGTCCTGAGCCAAATTATATTTCCAGTTTACCAAATCAAACTCTGAAATTCAAAAATGAAGTCAACGACGAAGTATCTGATAAGTTCAAAGGGATAGTTCTTGACGAAGTAACAGAAGTTTCTGTGAGAAAACAGGAACAAGACCAAATCAGAAACGAGCATATTGTTGATGCCAAAATTAATCAATATTACTACGTTTATGGTATTAGTCCACTAGACTTCGAACAGCCAAGAGCTCTATATGAAAAGGTATACAACGATGAACAGAAGAAATTATTCGTTCATAACGTTGTTTGCCACGCTTGTAAGATCAAAGATCCTAAAGTCAAAAAGAGAGTTACGCAATACTTTGGTTTGCTAAACGAAGATTTGGGTAAAGTCATTGCAGAAGGCTTGGGAGTTCCTTGGGAACCTGTTGACCTTGAAGGTTATGCCAAGACTTGGTCCATTGCAAGTGCCAATTAA","protein_sequence":"MNVFGKKEEKQEKVYSLQNGFPYSHHPYASQYSRPDGPILLQDFHLLENIASFDRERVPERVVHAKGGGCRLEFELTDSLSDITYAAPYQNVGYKCPGLVRFSTVGGESGTPDTARDPRGVSFKFYTEWGNHDWVFNNTPVFFLRDAIKFPVFIHSQKRDPQSHLNQFQDTTIYWDYLTLNPESIHQITYMFGDRGTPASWASMNAYSGHSFIMVNKEGKDTYVQFHVLSDTGFETLTGDKAAELSGSHPDYNQAKLFTQLQNGEKPKFNCYVQTMTPEQATKFRYSVNDLTKIWPHKEFPLRKFGTITLTENVDNYFQEIEQVAFSPTNTCIPGIKPSNDSVLQARLFSYPDTQRHRLGANYQQLPVNRPRNLGCPYSKGDSQYTAEQCPFKAVNFQRDGPMSYYNFGPEPNYISSLPNQTLKFKNEDNDEVSDKFKGIVLDEVTEVSVRKQEQDQIRNEHIVDAKINQYYYVYGISPLDFEQPRALYEKVYNDEQKKLFVHNVVCHACKIKDPKVKKRVTQYFGLLNEDLGKVIAECLGVPWEPVDLEGYAKTWSIASAN"},{"created_at":"2011-05-27T08:44:57.000Z","updated_at":"2011-07-22T17:54:23.000Z","name":"Peroxisomal catalase A","uniprot_id":"P15202","uniprot_name":"CATA_YEAST","enzyme":true,"transporter":false,"gene_name":"CTA1","num_residues":515,"molecular_weight":"58555.19922","theoretical_pi":"7.49","general_function":"Involved in catalase activity","specific_function":"Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide","reactions":[{"id":1368,"direction":"\u003e","locations":"peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2820,"direction":"\u003e","locations":"Peroxisome;Cytoplasm","altext":"2 H(2)O(2) = O(2) + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1A4E","cellular_location":"Peroxisome","genbank_gene_id":"X13028","genbank_protein_id":"3605","gene_card_id":"CTA1","chromosome_location":"chromosome 4","locus":"YDR256C","synonyms":[],"enzyme_classes":["1.11.1.6"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" antioxidant activity"},{"category":"Function","description":" peroxidase activity"},{"category":"Function","description":" catalase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" response to stimulus"},{"category":"Process","description":" response to stress"},{"category":"Process","description":" response to oxidative stress"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Catalase","identifier":"PF00199"},{"name":"Catalase-rel","identifier":"PF06628"}],"pathways":[{"name":"Tryptophan metabolism","kegg_map_id":"00380"},{"name":"Methane 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c peroxidase, mitochondrial","uniprot_id":"P00431","uniprot_name":"CCPR_YEAST","enzyme":true,"transporter":false,"gene_name":"CCP1","num_residues":361,"molecular_weight":"40352.69922","theoretical_pi":"6.32","general_function":"Involved in peroxidase activity","specific_function":"Destroys radicals which are normally produced within the cells and which are toxic to biological systems","reactions":[{"id":2823,"direction":"\u003e","locations":"Mitochondrion matrix","altext":"2 ferrocytochrome c + H(2)O(2) = 2 ferricytochrome c + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1ZBZ","cellular_location":"Mitochondrion matrix","genbank_gene_id":"AY557921","genbank_protein_id":"45269733","gene_card_id":"CCP1","chromosome_location":"chromosome 11","locus":"YKR066C","synonyms":["CCP"],"enzyme_classes":["1.11.1.5"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" iron ion binding"},{"category":"Function","description":" heme binding"},{"category":"Function","description":" antioxidant activity"},{"category":"Function","description":" peroxidase activity"},{"category":"Function","description":" binding"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" response to stimulus"},{"category":"Process","description":" response to stress"},{"category":"Process","description":" response to oxidative stress"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"peroxidase","identifier":"PF00141"}],"pathways":[],"gene_sequence":"ATGACTACTGCTGTTAGGCTTTTACCTTCACTGGGCAGAACCGCCCATAAGAGGTCTCTCTACCTGTTCTCCGCTGCTGCTGCTGCTGCTGCTGCTGCAACTTTTGCTTACTCGCAATCCCAAAAGAGATCATCGTCTTCTCCCGGGGGTGGTAGTAACCACGGATGGAACAACTGGGGGAAGGCAGCTGCTTTGGCTTCCACTACACCGCTCGTTCATGTCGCCTCTGTCGAAAAAGGGAGGTCATACGAGGACTTCCAAAAGGTGTACAATGCGATTGCACTCAAGCTGAGGGAAGATGACGAATATGACAACTATATAGGCTATGGGCCCGTATTAGTCCGTCTTGCTTGGCACACTTCAGGGACCTGGGACAAGCACGACAATACAGGCGGGTCATACGGTGGTACATACAGATTCAAAAAGGAGTTTAACGATCCATCCAATGCGGGCTTGCAGAATGGCTTCAAGTTCCTGGAGCCCATTCACAAAGAGTTTCCCTGGATCTCCTCGGGTGATCTGTTCAGTCTAGGGGGTGTCACTGCCGTGCAGGAAATGCAGGGTCCCAAGATTCCATGGAGATGTGGTAGAGTCGACACGCCAGAGGATACTACCCCTGACAACGGGAGACTGCCTGACGCTGATAAAGACGCTGACTATGTCAGAACATTTTTTCAAAGACTTAATATGAATGACAGAGAAGTAGTTGCTCTTATGGGGGCTCACGCTCTGGGCAAGACCCACTTGAAGAACTCTGGATACGAAGGGCCATGGGGAGCCGCTAACAACGTCTTTACCAATGAGTTTTACTTGAACATGCTGAATGAAGACTGGAAATTGGAAAAGAACGACGCGAACAACGAACAGTGGGACTCTAAGAGCGGCTACATGATGCTGCCCACTGATTATTCTTTGATTCAGGATCCCAAGTACTTAAGCATTGTGAAAGAATACGCTAATGACCAGGACAAGTTCTTCAAGGATTTTTCCAAAGCTTTTGAAAAACTGTTGGAGAACGGTATCACTTTCCCTAAAGACGCGCCCAGTCCATTTATTTTCAAGACTTTAGAGGAACAAGGTTTATAG","protein_sequence":"MTTAVRLLPSLGRTAHKRSLYLFSAAAAAAAAATFAYSQSQKRSSSSPGGGSNHGWNNWGKAAALASTTPLVHVASVEKGRSYEDFQKVYNAIALKLREDDEYDNYIGYGPVLVRLAWHTSGTWDKHDNTGGSYGGTYRFKKEFNDPSNAGLQNGFKFLEPIHKEFPWISSGDLFSLGGVTAVQEMQGPKIPWRCGRVDTPEDTTPDNGRLPDADKDADYVRTFFQRLNMNDREVVALMGAHALGKTHLKNSGYEGPWGAANNVFTNEFYLNLLNEDWKLEKNDANNEQWDSKSGYMMLPTDYSLIQDPKYLSIVKEYANDQDKFFKDFSKAFEKLLENGITFPKDAPSPFIFKTLEEQGL"},{"created_at":"2011-05-27T09:49:08.000Z","updated_at":"2011-05-27T15:01:31.000Z","name":"FAD-linked sulfhydryl oxidase ERV2","uniprot_id":"Q12284","uniprot_name":"ERV2_YEAST","enzyme":true,"transporter":false,"gene_name":"ERV2","num_residues":196,"molecular_weight":"22141.30078","theoretical_pi":"7.5","general_function":"Involved in thiol oxidase activity","specific_function":"FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen in parallel to ERO1","reactions":[{"id":2824,"direction":"\u003e","locations":"Mitochondrion intermembrane space; Lumenal side; Single-pass type III membrane protein;Endoplasmic reticulum membrane","altext":"4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"13-35","pdb_id":"1JRA","cellular_location":"Endoplasmic reticulum membrane; Single-pass type III membrane protein; Lumenal side","genbank_gene_id":"Z68111","genbank_protein_id":"1072405","gene_card_id":"ERV2","chromosome_location":"chromosome 16","locus":"YPR037C","synonyms":[],"enzyme_classes":["1.8.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"},{"category":"Function","description":" thiol oxidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Evr1_Alr","identifier":"PF04777"}],"pathways":[],"gene_sequence":"ATGAAACAGATAGTCAAAAGAAGCCATGCCATCAGAATAGTTGCAGCATTAGGAATCATAGGCCTGTGGATGTTTTTCTCGTCTAATGAACTATCCATCGCTACGCCGGGCCTAATCAAGGCGAAGTCTGGTATAGATGAAGTGCAAGGGGCGGCTGCTGAGAAGAACGACGCTCGGTTGAAAGAGATCGAGAAGCAAACCATTATGCCATTGATGGGCGATGACAAGGTGAAGAAGGAAGTGGGCAGGGCGTCGTGGAAGTACTTCCATACCCTGCTGGCCCGTTTTCCGGACGAGCCTACTCCTGAAGAAAGAGAGAAACTGCACACGTTTATTGGGTTGTATGCAGAACTCTATCCATGCGGGGAATGTTCATATCACTTTGTAAAGTTGATTGAGAAGTATCCCGTACAGACATCTAGCAGGACGGCTGCCGCAATGTGGGGATGCCACATTCACAACAAGGTGAACGAATACCTAAAGAAAGACATATATGACTGTGCTACCATCCTGGAGGACTACGATTGTGGATGTAGTGACAGCGACGGTAAACGCGTGTCTCTCGAGAAGGAGGCTAAACAGCACGGTTGA","protein_sequence":"MKQIVKRSHAIRIVAALGIIGLWMFFSSNELSIATPGLIKAKSGIDEVQGAAAEKNDARLKEIEKQTIMPLMGDDKVKKEVGRASWKYFHTLLARFPDEPTPEEREKLHTFIGLYAELYPCGECSYHFVKLIEKYPVQTSSRTAAAMWGCHIHNKVNEYLKKDIYDCATILEDYDCGCSDSDGKRVSLEKEAKQHG"},{"created_at":"2011-05-27T09:49:50.000Z","updated_at":"2011-05-29T05:06:49.000Z","name":"Mitochondrial FAD-linked sulfhydryl oxidase ERV1","uniprot_id":"P27882","uniprot_name":"ERV1_YEAST","enzyme":true,"transporter":false,"gene_name":"ERV1","num_residues":189,"molecular_weight":"21639.30078","theoretical_pi":"8.36","general_function":"Involved in thiol oxidase activity","specific_function":"FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (IMS). Forms a redox cycle with MIA40 that involves a disulfide relay system. Important for maintaining the cysteine residues in MIA40 in an oxidized state. Reduced ERV1 is reoxidized by cytochrome c. Required for the maturation of cytoplasmic, but not of mitochondrial Fe/S proteins","reactions":[{"id":2824,"direction":"\u003e","locations":"Mitochondrion intermembrane space; Lumenal side; Single-pass type III membrane protein;Endoplasmic reticulum membrane","altext":"4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)O.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion intermembrane space","genbank_gene_id":"Z72814","genbank_protein_id":"1945314","gene_card_id":"ERV1","chromosome_location":"chromosome 7","locus":"YGR029W","synonyms":["14 kDa regulatory protein","Essential for respiration and vegetative growth protein 1"],"enzyme_classes":["1.8.3.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"},{"category":"Function","description":" thiol oxidase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Evr1_Alr","identifier":"PF04777"}],"pathways":[],"gene_sequence":"ATGAAAGCAATAGATAAAATGACGGATAATCCACCACAAGAAGGCTTAAGTGGGAGGAAAATAATATATGACGAAGATGGCAAACCTTGCCGATCATGTAACACCCTACTTGACTTTCAGTACGTGACCGGGAAGATATCTAATGGCCTGAAGAACCTCTCATCTAACGGTAAACTAGCAGGTACGGGGGCTCTCACTGGCGAAGCTTCAGAGTTGATGCCTGGCTCAAGAACATACAGGAAGGTTGACCCTCCTGACGTAGAGCAACTAGGTAGATCTTCATGGACGCTGTTACACTCTGTAGCTGCCAGCTATCCTGCTCAACCTACAGACCAACAGAAGGGTGAAATGAAACAGTTCTTGAATATCTTCTCACATATTTATCCTTGCAACTGGTGTGCTAAAGACTTTGAAAAATATATCAGAGAAAATGCACCACAAGTTGAGTCAAGAGAAGAACTTGGGAGGTGGATGTGTGAAGCCCACAATAAAGTCAATAAGAAATTGAGGAAGCCCAAATTTGACTGTAATTTCTGGGAAAAAAGATGGAAGGACGGCTGGGACGAATAA","protein_sequence":"MKAIDKMTDNPPQEGLSGRKIIYDEDGKPCRSCNTLLDFQYVTGKISNGLKNLSSNGKLAGTGALTGEASELMPGSRTYRKVDPPDVEQLGRSSWTLLHSVAASYPAQPTDQQKGEMKQFLNIFSHIYPCNWCAKDFEKYIRENAPQVESREELGRWMCEAHNKVNKKLRKPKFDCNFWEKRWKDGWDE"}]}