Hydrogen peroxide (YMDB00888)

General function:

Involved in glutathione peroxidase activity

Specific function:

May constitute a glutathione peroxidase-like protective system against oxidative stresses

Gene Name:

GPX2

Uniprot ID:

P38143

Molecular weight:

18406.0

Reactions

General function:

Involved in D-arabinono-1,4-lactone oxidase activity

Specific function:

Can oxidize L-gulono-1,4-lactone as well as D-arabinono- 1,4-lactone and L-galactono-1,4-lactone

Gene Name:

ALO1

Uniprot ID:

P54783

Molecular weight:

59493.19922

Reactions

General function:

Involved in pyridoxamine-phosphate oxidase activity

Specific function:

Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

Gene Name:

PDX3

Uniprot ID:

P38075

Molecular weight:

26908.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Involved in the production of beta-alanine, a precursor of pantothenic acid. Multicopy suppressor of fenpropimorph resistance

Gene Name:

FMS1

Uniprot ID:

P50264

Molecular weight:

57805.10156

Reactions

General function:

Involved in acyl-CoA dehydrogenase activity

Specific function:

Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2)

Gene Name:

POX1

Uniprot ID:

P13711

Molecular weight:

84041.39844

Reactions

General function:

Involved in glutathione peroxidase activity

Specific function:

May constitute a glutathione peroxidase-like protective system against oxidative stresses

Gene Name:

GPX1

Uniprot ID:

P36014

Molecular weight:

19484.5

Reactions

General function:

Involved in oxygen-dependent protoporphyrinogen oxidase activity

Specific function:

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX

Gene Name:

HEM14

Uniprot ID:

P40012

Molecular weight:

59702.39844

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

Gene Name:

HEM13

Uniprot ID:

P11353

Molecular weight:

37711.30078

Reactions

General function:

Involved in electron carrier activity

Specific function:

Could be a fumarate reductase

Gene Name:

OSM1

Uniprot ID:

P21375

Molecular weight:

55064.80078

Reactions

General function:

Involved in electron carrier activity

Specific function:

Monothiol glutaredoxin involved in iron-sulfur biogenesis. Required for normal iron homeostasis. Protects cells against oxidative damage due to reactive oxygen species

Gene Name:

GRX5

Uniprot ID:

Q02784

Molecular weight:

16931.30078

Reactions

General function:

Involved in glutathione peroxidase activity

Specific function:

Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator YAP1, which is involved in transcription activation of genes of the oxidative stress response pathway. May also play a direct role in hydroperoxide scavenging, being the most active of three closely related S.cerevisiae peroxiredoxins (GPX1, GPX2, and HYP1/GPX3) with respect to peroxide and lipid hydroperoxide reduction. The three enzymes are not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, HYP1 is directly oxidized at Cys-36 to form a cysteine sulfenic acid (-SOH). Cys-36-SOH then forms either an intramolecular disulfide bond (Cys-36 with Cys-82) or a transient, intermolecular disulfide bond with 'Cys-598' of YAP1, which is further resolved into a YAP1 intramolecular disulfide bond ('Cys-303' with 'Cys-598') and a reduced Cys-36 in HYP1/GPX3

Gene Name:

HYR1

Uniprot ID:

P40581

Molecular weight:

18641.40039

Reactions

General function:

Involved in electron carrier activity

Specific function:

Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage

Gene Name:

GRX2

Uniprot ID:

P17695

Molecular weight:

15861.2998

Reactions

General function:

Involved in electron carrier activity

Specific function:

Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage

Gene Name:

GRX1

Uniprot ID:

P25373

Molecular weight:

12380.09961

Reactions

General function:

Involved in electron carrier activity

Specific function:

Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl- hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER- derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism. Through its capacity to inactivate the stress response transcription factor YAP1 and its regulator the hydroperoxide stress sensor HYR1, it is involved in feedback regulation of stress response gene expression upon oxidative stress

Gene Name:

TRX2

Uniprot ID:

P22803

Molecular weight:

11203.7998

Reactions

General function:

Involved in electron carrier activity

Specific function:

Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl- hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER- derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism

Gene Name:

TRX1

Uniprot ID:

P22217

Molecular weight:

11234.90039

Reactions

General function:

Involved in metal ion binding

Specific function:

Destroys radicals which are normally produced within the cells and which are toxic to biological systems

Gene Name:

SOD1

Uniprot ID:

P00445

Molecular weight:

15854.59961

Reactions

General function:

Involved in superoxide dismutase activity

Specific function:

Destroys radicals which are normally produced within the cells and which are toxic to biological systems

Gene Name:

SOD2

Uniprot ID:

P00447

Molecular weight:

25774.09961

Reactions

General function:

Involved in catalytic activity

Specific function:

In the de novo pyrimidine biosynthesic pathway, catalyzes the stereospecific oxidation of (S)-dihydroorotate to orotate and the reduction of fumarate to succinate. Does not use oxaloacetate and NAD or NADP as electron acceptors

Gene Name:

URA1

Uniprot ID:

P28272

Molecular weight:

34800.60156

Reactions

General function:

Involved in iron ion binding

Specific function:

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain

Gene Name:

CYC1

Uniprot ID:

P00044

Molecular weight:

12181.90039

Reactions

General function:

Involved in iron ion binding

Specific function:

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain

Gene Name:

CYC7

Uniprot ID:

P00045

Molecular weight:

12532.2998

Reactions

General function:

Involved in electron carrier activity

Specific function:

Not Available

Gene Name:

TRX3

Uniprot ID:

P25372

Molecular weight:

14432.0

General function:

Involved in catalase activity

Specific function:

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

Gene Name:

CTT1

Uniprot ID:

P06115

Molecular weight:

64583.0

Reactions

General function:

Involved in catalase activity

Specific function:

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide

Gene Name:

CTA1

Uniprot ID:

P15202

Molecular weight:

58555.19922

Reactions

General function:

Involved in peroxidase activity

Specific function:

Destroys radicals which are normally produced within the cells and which are toxic to biological systems

Gene Name:

CCP1

Uniprot ID:

P00431

Molecular weight:

40352.69922

Reactions

General function:

Involved in thiol oxidase activity

Specific function:

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen in parallel to ERO1

Gene Name:

ERV2

Uniprot ID:

Q12284

Molecular weight:

22141.30078

Reactions

General function:

Involved in thiol oxidase activity

Specific function:

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (IMS). Forms a redox cycle with MIA40 that involves a disulfide relay system. Important for maintaining the cysteine residues in MIA40 in an oxidized state. Reduced ERV1 is reoxidized by cytochrome c. Required for the maturation of cytoplasmic, but not of mitochondrial Fe/S proteins

Gene Name:

ERV1

Uniprot ID:

P27882

Molecular weight:

21639.30078

Reactions