{"ymdb_id":"YMDB00232","created_at":"2011-05-29T16:09:32.000Z","updated_at":"2016-10-18T17:11:22.000Z","name":"Spermidine","cas":"124-20-9","state":"Liquid","melting_point":"\u003c 25 oC","description":"Spermidine is a polyamine formed from putrescine and a precursor of spermine. Polyamines (e.g. spermidine, putrescine, spermine) are a ubiquitous group of compounds involved in many biological processes, including binding to nucleic acids, stabilizing membranes, and stimulating several enzymes. [Biocyc POLYAMINSYN3-PWY]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"extracellular;cytoplasm","synthesis_reference":"Bergeron, Raymond J., Jr.  Preparation and formulation spermidine analogues for pharmaceutical use as tumor growth inhibitors.    U.S.  (2001),     31 pp.","chebi_id":"16610","hmdb_id":"HMDB01257","kegg_id":"C00315","pubchem_id":"1102","cs_id":"1071","foodb_id":null,"wikipedia_link":"Spermidine","biocyc_id":"SPERMIDINE","iupac":"(4-aminobutyl)(3-aminopropyl)amine","traditional_iupac":"spermidine","logp":"-1.1495639400000002","pka":null,"alogps_solubility":"3.27e+01 g/l","alogps_logp":"-0.62","alogps_logs":"-0.65","acceptor_count":"3","donor_count":"3","rotatable_bond_count":"7","polar_surface_area":"64.07","refractivity":"44.968399999999995","polarizability":"18.802478340004217","formal_charge":"0","physiological_charge":"3","pka_strongest_basic":"10.676624477088431","pka_strongest_acidic":null,"bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["1,5,10-Triazadecane","1,8-Diamino-4-azaoctane","4-Azaoctamethylenediamine","4-Azaoctane-1,8-diamine","Aminopropylbutandiamine","N-(3-Aminopropyl)-1,4-butane-diamine","N-(3-Aminopropyl)-1,4-butanediamine","N-(3-Aminopropyl)-1,4-diamino-butane","N-(3-Aminopropyl)-1,4-diaminobutane","N-(3-Aminopropyl)-4-aminobutylamine","N-(4-Aminobutyl)-1,3-diaminopropane","N-(gamma-aminopropyl)tetramethylenediamine","SPD","Spermidin","Spermidine"],"pathways":[{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"}],"growth_conditions":[{"growth_media":"YEB media with 0.5 mM glucose","concentration":"1339.0","concentration_units":"\u0026#181;M","error":"67.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":18625006,"citation":"Pirkov, I., Norbeck, J., Gustafsson, L., Albers, E. (2008). \"A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.\" FEBS J 275:4111-4120."},{"pubmed_id":17218313,"citation":"Uemura, T., Kashiwagi, K., Igarashi, K. (2007). \"Polyamine uptake by DUR3 and SAM3 in Saccharomyces cerevisiae.\" J Biol Chem 282:7733-7741."}],"proteins":[{"created_at":"2011-05-24T19:37:34.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"General amino-acid permease GAP1","uniprot_id":"P19145","uniprot_name":"GAP1_YEAST","enzyme":false,"transporter":true,"gene_name":"GAP1","num_residues":602,"molecular_weight":"65654.89844","theoretical_pi":"8.67","general_function":"Involved in transport","specific_function":"Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine","reactions":[],"signal_regions":"None","transmembrane_regions":"96-116;122-142;166-185;205-224;238-256;281-298;322-342;377-396;422-442;452-472;492-510;530-548","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY723840","genbank_protein_id":"51830440","gene_card_id":"GAP1","chromosome_location":"chromosome 11","locus":"YKR039W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGAGTAATACTTCTTCGTACGAGAAGAATAATCCAGATAATCTGAAACACAATGGTATTACCATAGATTCTGAGTTTCTAACTCAGGAGCCAATAACCATTCCCTCAAATGGCTCCGCTGTTTCTATTGACGAAACAGGTTCAGGGTCCAAATGGCAAGACTTTAAAGATTCTTTCAAAAGGGTAAAACCTATTGAAGTTGATCCTAATCTTTCAGAAGCTGAAAAAGTGGCTATCATCACTGCCCAAACTCCATTGAAGCACCACTTGAAGAATAGACATTTGCAAATGATTGCCATCGGTGGTGCCATCGGTACTGGTCTGCTGGTTGGGTCAGGTACTGCACTAAGAACAGGTGGTCCCGCTTCGCTACTGATTGGATGGGGGTCTACAGGTACCATGATTTACGCTATGGTTATGGCTCTGGGTGAGTTGGCTGTTATCTTCCCTATTTCGGGTGGGTTCACCACGTACGCTACCAGATTTATTGATGAGTCCTTTGGTTACGCTAATAATTTCAATTATATGTTACAATGGTTGGTTGTGCTACCATTGGAAATTGTCTCTGCATCTATTACTGTAAATTTCTGGGGTACAGATCCAAAGTATAGAGATGGGTTTGTTGCGTTGTTTTGGCTTGCAATTGTTATCATCAATATGTTTGGTGTCAAAGGTTATGGTGAAGCAGAATTCGTCTTTTCATTTATCAAGGTCATCACTGTTGTTGGGTTCATCATCTTAGGTATCATTCTAAACTGTGGTGGTGGTCCAACAGGTGGTTACATTGGGGGCAAGTACTGGCATGATCCTGGTGCCTTTGCTGGTGACACTCCAGGTGCTAAATTCAAAGGTGTTTGTTCTGTCTTCGTCACCGCTGCCTTTTCTTTTGCCGGTTCAGAATTGGTTGGTCTTGCTGCCAGTGAATCCGTAGAGCCTAGAAAGTCCGTTCCTAAGGCTGCTAAACAAGTTTTCTGGAGAATCACCCTATTTTATATTCTGTCGCTATTAATGATTGGTCTTTTAGTCCCATACAACGATAAAAGTTTGATTGGTGCCTCCTCTGTGGATGCTGCTGCTTCACCCTTCGTCATTGCCATTAAGACTCACGGTATCAAGGGTTTGCCAAGTGTTGTCAACGTCGTTATCTTGATTGCCGTGTTATCTGTCGGTAACTCTGCCATTTATGCATGTTCCAGAACAATGGTTGCCCTAGCTGAACAGAGATTTCTGCCAGAAATCTTTTCCTACGTTGACCGTAAGGGTAGACCATTGGTGGGAATTGCTGTCACATCTGCATTCGGTCTTATTGCGTTTGTTGCCGCCTCCAAAAAGGAAGGTGAAGTTTTCAACTGGTTACTAGCCTTGTCTGGGTTGTCATCTCTATTCACATGGGGTGGTATCTGTATTTGTCACATTCGTTTCAGAAAGGCATTGGCCGCCCAAGGAAGAGGCTTGGATGAATTGTCTTTCAAGTCTCCTACCGGTGTTTGGGGTTCCTACTGGGGGTTATTTATGGTTATTATTATGTTCATTGCCCAATTCTACGTTGCCGTATTCCCCGTGGGAGATTCTCCAAGTGCGGAAGGTTTCTTCGAAGCTTATCTATCCTTCCCACTTGTTATGGTTATGTACATCGGACACAAGATCTATAAGAGGAATTGGAAGCTTTTCATCCCAGCAGAAAAGATGGACATTGATACGGGTAGAAGAGAAGTCGATTTAGATTTGTTGAAACAAGAAATTGCAGAAGAAAAGGCAATTATGGCCACAAAGCCAAGATGGTATAGAATCTGGAATTTCTGGTGTTAA","protein_sequence":"MSNTSSYEKNNPDNLKHNGITIDSEFLTQEPITIPSNGSAVSIDETGSGSKWQDFKDSFKRVKPIEVDPNLSEAEKVAIITAQTPLKHHLKNRHLQMIAIGGAIGTGLLVGSGTALRTGGPASLLIGWGSTGTMIYAMVMALGELAVIFPISGGFTTYATRFIDESFGYANNFNYMLQWLVVLPLEIVSASITVNFWGTDPKYRDGFVALFWLAIVIINMFGVKGYGEAEFVFSFIKVITVVGFIILGIILNCGGGPTGGYIGGKYWHDPGAFAGDTPGAKFKGVCSVFVTAAFSFAGSELVGLAASESVEPRKSVPKAAKQVFWRITLFYILSLLMIGLLVPYNDKSLIGASSVDAAASPFVIAIKTHGIKGLPSVVNVVILIAVLSVGNSAIYACSRTMVALAEQRFLPEIFSYVDRKGRPLVGIAVTSAFGLIAFVAASKKEGEVFNWLLALSGLSSLFTWGGICICHIRFRKALAAQGRGLDELSFKSPTGVWGSYWGLFMVIIMFIAQFYVAVFPVGDSPSAEGFFEAYLSFPLVMVMYIGHKIYKRNWKLFIPAEKMDIDTGRREVDLDLLKQEIAEEKAIMATKPRWYRIWNFWC"},{"created_at":"2011-05-24T19:45:11.000Z","updated_at":"2011-05-27T14:55:58.000Z","name":"Urea active transporter","uniprot_id":"P33413","uniprot_name":"DUR3_YEAST","enzyme":false,"transporter":true,"gene_name":"DUR3","num_residues":735,"molecular_weight":"80616.10156","theoretical_pi":"5.36","general_function":"Involved in transporter activity","specific_function":"Required for active transport of urea","reactions":[],"signal_regions":"None","transmembrane_regions":"15-35;86-106;131-151;167-187;190-210;254-274;296-316;344-364;404-424;426-446;455-475;497-517;619-639;651-671","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"AY693170","genbank_protein_id":"51013791","gene_card_id":"DUR3","chromosome_location":"chromosome 8","locus":"YHL016C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"SSF","identifier":"PF00474"}],"pathways":[],"gene_sequence":"ATGGGAGAATTTAAACCTCCGCTACCTCAAGGCGCTGGGTACGCTATTGTATTGGGCCTAGGGGCCGTATTTGCAGGAATGATGGTTTTGACCACTTATTTACTGAAACGTTATCAAAAGGAAATCATCACAGCAGAAGAATTCACCACCGCCGGTAGATCTGTAAAAACCGGCTTAGTGGCTGCAGCCGTGGTTTCTAGTTGGATCTGGTGTTCTACATTGTTAACGTCGTCAACAAAGGAATATGCAGACGGTATATTTGGCGGTTATGCGTACGCTGCTGGCGCATGCTTCCAAATTATTGCATTCGCAATTTTGGCAATTAAAACCAAGCAAATGGCTCCCAATGCGCACACATATTTAGAATTAGTGAGAACAAGATATGGTAAGATCGGCCATGGTTGCTACTTGTTTTATGCCATCGCGACGAATATTTTAGTCACTTCAATGCTTTTAACTTCAGGTTCTGCTGTCTTTAGTGATTTAACCGGGATGAACACTATCGCATCATGTTTTTTACTGCCTGTGGGTGTTGTTGTTTATACTCTATTTGGTGGGATTAAAGCAACTTTCTTAACGGACTATATGCACACATGTGTCATTATCATCATTGTCCTCGTATTTGCCTTTAAAGTTTATGCGACTAGTGATGTTTTAGGCTCACCGGGAAAAGTTTATGACTTAGTTCGTGAAGCCGCCAAGAGGCATCCAGTAGACGGTAACTATCAGGGTGAATATATGACCATGACATCCAAATCCGCTGGTATTTTATTAATTATTAACCTGATTGGAAATTTCGGCACCGTTTTCCTTGATAATGGTTATTGGAATAAAGCGATTTCTGCTAGTCCCGCAGCGAGTTTGAAAGCATATGCCATCGGTGGGTTAGCATGGTTTGCAGTACCTTCTTTGATTTCATTGACCATGGGATTAGCATGTCTTGCGGTGGAAACGTCTCCGAACTTCCCCACCTATCCTGATCCACTTACTTCGTTCCAGGCAAATTCTGGGTTAGTCTTGCCGGCAGCTGCAATTGCTATCATGGGTAAGGGGGGTGCTGTGGCATCGCTGCTAATGATTTTCATGGCCGTCACATCTGCTATGTCTGCTGAACTAATTGCCGTTTCATCTGTTTTCACTTACGATATCTATAGAGAATATATTGATCCTCGTGCAAGCGGTAAGAAATTGATTTACACATCACACGTTGCTTGTATCTTTTTTGGTCTTGCCATGAGTGGATTTTCGGTTGGTTTATACTATGGTGGTATTTCTATGGGTTATATCTATGAAATGATGGGTATAATTATTAGTAGTGCAGTATTACCTGTCGTTTTGACCTTATGTTCCAAAGACATGAATTTGGTGGCCGCTGTAGTGTCGCCTATTTTGGGCACAGGACTGGCTATAATGTCATGGCTTGTCTGTACCAAATCCCTTTATAAAGAATTGACCGTGGATACTACGTTCATGGATTATCCAATGTTAACAGGTAACTTGGTGGCTTTGCTATCACCAGCCATTTTTATTCCTATTTTAACGTATGTGTTTAAGCCACAAAATTTTGACTGGGAGAAAATGAAAGATATTACTAGAGTTGACGAAACTGCAGAGTTAGTTCAGGCTGACCCTGATATCCAGCTTTACGATGCTGAAGCTAACGATAAGGAACAAGAAGAAGAAACAAATTCTCTGGTCTCAGATAGTGAAAAAAACGATGTTAGAGTAAATAATGAAAAATTGATTGAGCCTAACCTTGGTGTTGTAATAAGTAATGCCATTTTTCAAGAAGATGACACACAGTTACAAAATGAATTAGACGAAGAACAAAGAGAACTAGCACGTGGTTTAAAAATTGCATACTTCCTATGTGTTTTTTTCGCTTTGGCATTTTTGGTAGTTTGGCCCATGCCCATGTATGGTTCCAAATATATCTTCAGTAAAAAATTCTTTACCGGTTGGGTTGTTGTGATGATCATCTGGCTTTTTTTCAGTGCGTTTGCCGTTTGTATTTATCCACTCTGGGAAGGTAGGCATGGTATATATACCACTTTGCGAGGCCTTTACTGGGATCTATCTGGTCAAACTTATAAATTAAGGGAATGGCAAAATTCGAACCCACAAGATCTGCATGTAGTAACAAGCCAAATTAGTGCGAGAGCACATAGACAATCATCACATTTCGGACAAGTTGATGAAATAATTTAG","protein_sequence":"MGEFKPPLPQGAGYAIVLGLGAVFAGMMVLTTYLLKRYQKEIITAEEFTTAGRSVKTGLVAAAVVSSWIWCSTLLTSSTKEYADGIFGGYAYAAGACFQIIAFAILAIKTKQMAPNAHTYLELVRTRYGKIGHGCYLFYAIATNILVTSMLLTSGSAVFSDLTGMNTIASCFLLPVGVVVYTLFGGIKATFLTDYMHTCVIIIIVLVFAFKVYATSDVLGSPGKVYDLVREAAKRHPVDGNYQGEYMTMTSKSAGILLIINLIGNFGTVFLDNGYWNKAISASPAASLKAYAIGGLAWFAVPSLISLTMGLACLAVETSPNFPTYPDPLTSFQANSGLVLPAAAIAIMGKGGAVASLLMIFMAVTSAMSAELIAVSSVFTYDIYREYIDPRASGKKLIYTSHVACIFFGLAMSGFSVGLYYGGISMGYIYEMMGIIISSAVLPVVLTLCSKDMNLVAAVVSPILGTGLAIMSWLVCTKSLYKELTVDTTFMDYPMLTGNLVALLSPAIFIPILTYVFKPQNFDWEKMKDITRVDETAELVQADPDIQLYDAEANDKEQEEETNSLVSDSEKNDVRVNNEKLIEPNLGVVISNAIFQEDDTQLQNELDEEQRELARGLKIAYFLCVFFALAFLVVWPMPMYGSKYIFSKKFFTGWVVVMIIWLFFSAFAVCIYPLWEGRHGIYTTLRGLYWDLSGQTYKLREWQNSNPQDLHVVTSQISARAHRQSSHFGQVDEII"},{"created_at":"2011-05-24T21:12:04.000Z","updated_at":"2011-07-22T17:54:35.000Z","name":"Deoxyhypusine synthase","uniprot_id":"P38791","uniprot_name":"DHYS_YEAST","enzyme":true,"transporter":false,"gene_name":"DYS1","num_residues":387,"molecular_weight":"42891.80078","theoretical_pi":"5.49","general_function":"Involved in peptidyl-lysine modification to hypusine","specific_function":"Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue","reactions":[{"id":1444,"direction":"\u003e","locations":"mitochondrion;mitochondrial membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2367,"direction":"\u003e","locations":null,"altext":"[eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY558282","genbank_protein_id":"45270454","gene_card_id":"DYS1","chromosome_location":"chromosome 8","locus":"YHR068W","synonyms":["DHS"],"enzyme_classes":["2.5.1.46"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" peptidyl-amino acid modification"},{"category":"Process","description":" peptidyl-lysine modification"},{"category":"Process","description":" peptidyl-lysine modification to hypusine"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"}],"pfams":[{"name":"DS","identifier":"PF01916"}],"pathways":[],"gene_sequence":"ATGTCCGATATCAACGAAAAACTCCCAGAGTTACTACAAGACGCTGTCTTGAAAGCATCTGTTCCTATTCCAGATGACTTCGTTAAGGTTCAAGGTATTGATTACTCAAAGCCTGAAGCCACTAATATGAGAGCAACTGATTTAATTGAAGCTATGAAGACCATGGGTTTCCAAGCTAGTTCTGTTGGTACTGCCTGTGAGATTATTGATAGTATGAGATCATGGAGAGGTAAGCATATTGACGAATTGGATGACCATGAAAAGAAAGGTTGCTTCGATGAGGAAGGGTACCAAAAGACTACTATCTTCATGGGTTATACTTCTAACTTGATCAGTTCCGGTGTACGTGAAACTTTACGTTATTTGGTGCAACACAAAATGGTTGATGCTGTCGTTACTTCTGCTGGTGGTGTGGAAGAAGATTTGATCAAATGTCTTGCTCCAACTTACTTGGGTGAATTTGCTTTGAAAGGTAAATCTTTGCGTGACCAAGGTATGAATCGTATTGGTAACTTGCTTGTTCCAAATGATAACTACTGTAAGTTTGAAGAATGGATTGTCCCAATTTTGGATAAGATGTTGGAAGAACAAGATGAATACGTAAAGAAACATGGCGCTGACTGTTTAGAGGCTAACCAAGACGTGGATTCACCAATCTGGACCCCATCTAAGATGATAGACCGTTTTGGTAAGGAAATCAACGACGAATCCTCCGTATTGTACTGGGCCCACAAGAATAAAATTCCAATCTTTTGTCCATCTTTGACTGATGGTTCAATCGGTGACATGTTGTTTTTCCATACTTTTAAAGCATCTCCAAAACAACTAAGAGTTGACATTGTAGGAGATATCCGCAAAATCAATTCAATGTCCATGGCCGCTTACAGAGCCGGTATGATCATCTTGGGTGGTGGTTTGATCAAGCACCACATTGCCAATGCTTGTTTGATGAGAAATGGTGCTGATTATGCCGTTTACATTAACACTGGTCAAGAATACGATGGTTCTGATGCAGGTGCAAGACCTGACGAAGCTGTGTCTTGGGGTAAGATCAAGGCTGAAGCCAAATCCGTCAAACTTTTTGCTGATGTCACCACTGTTCTTCCATTGATTGTTGCTGCTACCTTTGCCAGTGGTAAACCAATCAAAAAAGTTAAGAATTGA","protein_sequence":"MSDINEKLPELLQDAVLKASVPIPDDFVKVQGIDYSKPEATNMRATDLIEAMKTMGFQASSVGTACEIIDSMRSWRGKHIDELDDHEKKGCFDEEGYQKTTIFMGYTSNLISSGVRETLRYLVQHKMVDAVVTSAGGVEEDLIKCLAPTYLGEFALKGKSLRDQGMNRIGNLLVPNDNYCKFEEWIVPILDKMLEEQDEYVKKHGADCLEANQDVDSPIWTPSKMIDRFGKEINDESSVLYWAHKNKIPIFCPSLTDGSIGDMLFFHTFKASPKQLRVDIVGDIRKINSMSMAAYRAGMIILGGGLIKHHIANACLMRNGADYAVYINTGQEYDGSDAGARPDEAVSWGKIKAEAKSVKLFADVTTVLPLIVAATFASGKPIKKVKN"},{"created_at":"2011-05-24T21:12:40.000Z","updated_at":"2011-05-27T15:00:57.000Z","name":"Polyamine oxidase FMS1","uniprot_id":"P50264","uniprot_name":"FMS1_YEAST","enzyme":true,"transporter":false,"gene_name":"FMS1","num_residues":508,"molecular_weight":"57805.10156","theoretical_pi":"5.38","general_function":"Amino acid transport and metabolism","specific_function":"Involved in the production of beta-alanine, a precursor of pantothenic acid. Multicopy suppressor of fenpropimorph resistance","reactions":[{"id":1903,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1906,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1907,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2368,"direction":"\u003e","locations":null,"altext":"Spermine + O(2) + H(2)O = spermidine + 3-aminopropanal + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2369,"direction":"\u003e","locations":null,"altext":"Spermidine + O(2) + H(2)O = putrescine + 3-aminopropanal + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2370,"direction":"\u003e","locations":null,"altext":"N(1)-acetylspermine + O(2) + H(2)O = spermidine + 3-acetamidopropanal + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2371,"direction":"\u003e","locations":null,"altext":"N(1)-acetylspermidine + O(2) + H(2)O = putrescine + 3-acetamidopropanal + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":2372,"direction":"\u003e","locations":null,"altext":"N(8)-acetylspermidine + O(2) + H(2)O = 4-acetamidobutanal + trimethylenediamine + H(2)O(2).","export":false,"pw_reaction_id":null,"source":null},{"id":3757,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006281","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1YY5","cellular_location":null,"genbank_gene_id":"X81848","genbank_protein_id":"1143556","gene_card_id":"FMS1","chromosome_location":"chromosome 13","locus":"YMR020W","synonyms":["Fenpropimorph resistance multicopy suppressor 1"],"enzyme_classes":["1.5.3.17"],"go_classes":[],"pfams":[{"name":"Amino_oxidase","identifier":"PF01593"}],"pathways":[{"name":"beta-Alanine metabolism","kegg_map_id":"00410"}],"gene_sequence":"ATGAATACAGTTTCACCAGCCAAAAAAAAGGTTATTATAATTGGTGCCGGTATTGCTGGGCTTAAAGCTGCATCTACGCTACACCAAAACGGTATTCAAGATTGTCTTGTTCTTGAGGCCAGAGATCGGGTCGGTGGTAGGTTGCAAACTGTCACAGGCTATCAAGGTCGGAAATATGATATAGGTGCTAGCTGGCACCATGATACGTTGACAAACCCTTTATTTTTGGAAGAGGCTCAACTGAGTTTGAATGATGGGAGAACGAGGTTTGTTTTTGATGACGATAATTTTATTTATATCGACGAAGAACGTGGAAGGGTAGACCATGACAAGGAACTGCTTCTTGAAATTGTGGACAATGAAATGAGCAAATTCGCAGAGTTAGAATTCCATCAACACTTAGGAGTTTCAGATTGCTCCTTTTTTCAATTAGTAATGAAATACTTACTACAAAGACGCCAATTTCTCACAAATGACCAAATAAGATATTTGCCACAACTCTGTCGATATCTGGAATTGTGGCACGGCTTAGATTGGAAGCTTTTGAGTGCCAAGGATACATACTTCGGTCACCAAGGAAGGAACGCCTTTGCTTTGAACTATGATTCTGTGGTTCAAAGAATTGCTCAAAGCTTTCCTCAAAATTGGTTAAAGCTAAGTTGTGAAGTGAAATCAATTACACGAGAACCTTCAAAAAATGTGACAGTGAACTGTGAAGATGGTACTGTGTACAATGCTGATTATGTTATTATTACAGTACCTCAAAGTGTATTGAATTTGTCTGTACAACCTGAAAAAAATTTACGGGGAAGAATAGAATTTCAACCACCCTTGAAACCAGTGATTCAAGATGCTTTTGACAAGATCCATTTTGGAGCGCTAGGTAAAGTAATTTTTGAGTTTGAAGAATGTTGTTGGTCGAACGAAAGTTCAAAAATTGTAACTTTGGCTAACTCTACCAATGAATTTGTCGAAATAGTACGTAATGCGGAAAATTTAGATGAATTAGACTCTATGCTAGAAAGGGAAGATTCTCAAAAGCATACGAGTGTTACTTGTTGGAGCCAGCCTTTATTTTTCGTAAATTTGTCAAAAAGCACAGGAGTAGCAAGCTTTATGATGTTGATGCAGGCACCGCTTACAAATCACATAGAATCCATTAGAGAAGATAAAGAGCGTCTTTTTAGTTTTTTCCAACCTGTGCTGAACAAGATTATGAAGTGTCTAGATTCTGAGGATGTCATCGACGGAATGAGGCCGATAGAAAACATTGCAAACGCTAATAAACCAGTCTTAAGAAACATCATCGTTAGCAACTGGACACGCGATCCTTACTCACGCGGTGCTTATTCGGCCTGTTTTCCAGGAGATGATCCAGTTGATATGGTTGTTGCAATGTCTAATGGTCAAGACTCCCGCATAAGATTTGCAGGCGAACATACTATCATGGACGGCGCCGGCTGTGCCTATGGTGCTTGGGAAAGCGGAAGACGGGAGGCGACTCGAATCTCTGACTTACTGAAATAG","protein_sequence":"MNTVSPAKKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGRKYDIGASWHHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERGRVDHDKELLLEIVDNEMSKFAELEFHQHLGVSDCSFFQLVMKYLLQRRQFLTNDQIRYLPQLCRYLELWHGLDWKLLSAKDTYFGHQGRNAFALNYDSVVQRIAQSFPQNWLKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQSVLNLSVQPEKNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEECCWSNESSKIVTLANSTNEFVEIVRNAENLDELDSMLEREDSQKHTSVTCWSQPLFFVNLSKSTGVASFMMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKCLDSEDVIDGMRPIENIANANKPVLRNIIVSNWTRDPYSRGAYSACFPGDDPVDMVVAMSNGQDSRIRFAGEHTIMDGAGCAYGAWESGRREATRISDLLK"},{"created_at":"2011-05-27T02:18:28.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Spermine synthase","uniprot_id":"Q12455","uniprot_name":"SPSY_YEAST","enzyme":true,"transporter":false,"gene_name":"SPE4","num_residues":300,"molecular_weight":"34090.5","theoretical_pi":"4.77","general_function":"Involved in catalytic activity","specific_function":"S-adenosylmethioninamine + spermidine = 5'- methylthioadenosine + spermine","reactions":[{"id":1971,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2669,"direction":"\u003e","locations":null,"altext":"S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine.","export":false,"pw_reaction_id":null,"source":null},{"id":3762,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006286","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AF067970","genbank_protein_id":"3201943","gene_card_id":"SPE4","chromosome_location":"chromosome 12","locus":"YLR146C","synonyms":["SPMSY","Spermidine aminopropyltransferase"],"enzyme_classes":["2.5.1.22"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Spermine_synth","identifier":"PF01564"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGGTTAATAATTCACAGCATCCTTACATCAAAGATGGATGGTTTAGAGAGATTAATGATAAAAGTTTTCCGGGCCAGGCCTTTACTATGACCGTGGACTCAATACTTTATGAAGCCCGCAGTGAATTTCAGGACATCTTAATCTTCCGTAACAAGGTATACGGTACTGTTTTGGTCCTCGATGGTATTGTCCAATGTACGGAATTTGATGAGTTTGCCTATCAAGAGATGATCACCCACATTGCCATGTTTGCGCATTCTAATCCCAAGCGTGTACTTATCATTGGCGGTGGGGACGGAGGTGTCTTAAGGGAAGTAGCCAAGCACAGCTGTGTAGAAGATATCACTATGGTAGAAATTGACTCATCAGTGATCGAATTATCCCGTAAGTTCTTGCCCACATTGAGTAATGGTGCTTTCGATGACGAAAGGTTGGACTTGAAACTTTGCGATGGCTTCAAGTTCTTACAAGATATAGGTGCTTCCGACGTCCATAAGAAATTTGACGTCATTATTACAGATAGTTCTGATCCTGAAGGTCCAGCTGAAGCGTTTTTTCAAGAGAGGTATTTCGAACTATTGAAAGATGCTTTAAATCCTAATGGCGTTGTTATTATGCAAAGCTCTGAAAATTTTTGGTTAAATTTAAAATACTTACATGATTTGAAAAATACAGCCAAAAAGGTATTTCCTAATACAGAATATTGCTATACCATGGTTCCAACCTATACATCTGGCCAATTAGGTTTAATTGTTTGCAGTAATAACGCCAATATACCGTTGAACATTCCGCAAAGAAAGATATCTGAGCAAGAACAAGGGAAGCTGAAGTACTATAATCCTCAAATACATTCTAGTGCGTTTGTTTTGCCTACTTGGGCAGACAAGGTCATTAATGAATGA","protein_sequence":"MVNNSQHPYIKDGWFREINDKSFPGQAFTMTVDSILYEARSEFQDILIFRNKVYGTVLVLDGIVQCTEFDEFAYQEMITHIAMFAHSNPKRVLIIGGGDGGVLREVAKHSCVEDITMVEIDSSVIELSRKFLPTLSNGAFDDERLDLKLCDGFKFLQDIGASDVHKKFDVIITDSSDPEGPAEAFFQERYFELLKDALNPNGVVIMQSSENFWLNLKYLHDLKNTAKKVFPNTEYCYTMVPTYTSGQLGLIVCSNNANIPLNIPQRKISEQEQGKLKYYNPQIHSSAFVLPTWADKVINE"},{"created_at":"2011-05-27T02:18:58.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Spermidine synthase","uniprot_id":"Q12074","uniprot_name":"SPEE_YEAST","enzyme":true,"transporter":false,"gene_name":"SPE3","num_residues":293,"molecular_weight":"33323.80078","theoretical_pi":"5.24","general_function":"Involved in catalytic activity","specific_function":"S-adenosylmethioninamine + putrescine = 5'-S- methyl-5'-thioadenosine + spermidine","reactions":[{"id":1970,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2670,"direction":"\u003e","locations":null,"altext":"S-adenosylmethioninamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.","export":false,"pw_reaction_id":null,"source":null},{"id":3759,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006283","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U27519","genbank_protein_id":"1326074","gene_card_id":"SPE3","chromosome_location":"chromosome 16","locus":"YPR069C","synonyms":["SPDSY","Putrescine aminopropyltransferase"],"enzyme_classes":["2.5.1.16"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"Spermine_synth","identifier":"PF01564"}],"pathways":[{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"beta-Alanine metabolism","kegg_map_id":"00410"},{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"gene_sequence":"ATGGCACAAGAAATCACTCACCCAACTATTGTAGACGGCTGGTTCAGAGAAATTTCTGATACCATGTGGCCAGGCCAGGCCATGACTTTAAAAGTGGAGAAAGTTTTACACCATGAGAAGTCAAAATATCAAGACGTTTTGATCTTCAAATCCACTACATATGGTAATGTTCTAGTTTTAGATAATGTAATTCAAGCCACCGAAAGGGATGAATTTGCCTACCAAGAAATGATTGCCCATCTTGCCTTGAATTCCCATCCAAATCCTAAGAAGGTTCTTGTTATTGGTGGGGGTGATGGTGGTGTTTTGAGAGAGGTTGTCAAGCATGATTCCGTTGAGGAAGCCTGGTTATGTGACATTGATGAAGCTGTTATTAGACTATCAAAGGAGTACCTACCAGAAATGGCTGCCTCTTATTCTCACCCAAAGGTTAAGACCCACATTGGTGATGGTTTCCAATTTTTAAGAGATTACCAAAACACATTTGACGTAATCATTACTGACTCTTCTGACCCAGAAGGTCCAGCTGAAACCCTTTTCCAAAAGGAATATTTCCAATTGTTGAACAGTGCGTTGACAGAAAAGGGTGTAATCACTACACAAGCAGAAAGTATGTGGATTCACTTGCCAATCATTAAGGACTTAAAGAAAGCCTGTTCTGAAGTTTTCCCAGTTGCAGAATACTCTTTCGTTACTATTCCAACTTACCCAACTGGTACGATTGGTTTTATGGTTTGCTCCAAAGATAAAACTTGCAATGTCAAGAAGCCACTACGTGAAATCTCTGATGAGAAGGAGGCTGAATTATACAGATACTATAACAAGAAAATTCACGAAGCTTCCTTTGTTCTACCAACCTGGGCAGCCAAGGAATTAAATTAG","protein_sequence":"MAQEITHPTIVDGWFREISDTMWPGQAMTLKVEKVLHHEKSKYQDVLIFKSTTYGNVLVLDNVIQATERDEFAYQEMIAHLALNSHPNPKKVLVIGGGDGGVLREVVKHDSVEEAWLCDIDEAVIRLSKEYLPEMAASYSHPKVKTHIGDGFQFLRDYQNTFDVIITDSSDPEGPAETLFQKEYFQLLNSALTEKGVITTQAESMWIHLPIIKDLKKACSEVFPVAEYSFVTIPTYPTGTIGFMVCSKDKTCNVKKPLREISDEKEAELYRYYNKKIHEASFVLPTWAAKELN"},{"created_at":"2011-05-27T02:20:44.000Z","updated_at":"2011-06-05T02:38:41.000Z","name":"Polyamine transporter TPO5","uniprot_id":"P36029","uniprot_name":"TPO5_YEAST","enzyme":false,"transporter":true,"gene_name":"TPO5","num_residues":618,"molecular_weight":"69242.0","theoretical_pi":"5.02","general_function":"Involved in transport","specific_function":"Required for polyamine transport. Transports putrescine effectively and spermidine less effectively","reactions":[],"signal_regions":"None","transmembrane_regions":"61-84;91-110;132-148;155-171;180-200;212-231;298-317;343-367;403-419;426-449;465-486;499-516","pdb_id":null,"cellular_location":"Golgi apparatus membrane; Multi-pass membrane protein","genbank_gene_id":"Z26878","genbank_protein_id":"407507","gene_card_id":"TPO5","chromosome_location":"chromosome 11","locus":"YKL174C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGCCAGAGTATACGCTACTGGCTGATAATATAAGGGAGAATATCGTTCATTTCGATCCGAATGGTTTGTTTGATAACTTGCACACCATTGTTCATGAAGATGACAGTCAAGAGAACGAGGAGGCCGAGCATTTCAATTATGATCAGGTGTTGGATAAATCGTTATTGTCAAGAGGTTCTATTGTCGGTCTCGGTTTAGGACTAATGAGTCCCGTTTTAGGAATGTGCACTAGTATGGCCATTGGGCTAATTAATGGTGGTCCGTTAACTATAATGCTAGGTTTTTTAATCAGTGGAGTGTGTATATGGTTTTCGTCGCTTTCTCTTGGTGAGATTGTTTCAAAATTTCCGATGGAACTGCATGTTGGGAGTGCCATGTTGGCCCCGGAGAAATTGAAATTAGTATGTTCGTGGTACACTGGCTGGTTAATGCTCATAGGGAATTGGACTATGAGTACCAGTATTACTTTTGCAGGCGCTCAACTTACCATTTCTTTGATTCTGATGACGAACTCCAACCTAATATCCGAGGCACACTTGATTTTTTACACAGTCATTGTATTTTACTTAGTTGTGACTGTTGTAGGCCTCGTGAATTTGAAATTTGCAAGATTTATTGAAACAATAAACAAAGTCTGTGTTTATTGGATCATATATGCCATTATATTTATTGATATTCTTCTACTAGTATTCCACAAAGGTAAATTTCGATCTTTGAAGTACGCGCTATTTCACTTTGATAATAATCTATCAGGGTATAAAAGCGCATTTCTTTCCTTCATCATTGGATTCCAACAGTCTAATTTCACGTTACAAGGTTTCAGTATGTTACCTGCTTTAGCTGACGAAGTCAAAGTTCCTGAGAAGGATATTCCACGTGGTATGTCGAATGCGGTATTGTTATCCGCGTTCTCTGGAGTCATTTTTCTTATACCAATAATGTTAATCCTGCCAGATAATGATTTGCTTTTTACCAATCATAAGGTTCTACCAATAGTGAACATTTTTACAAAATCGACTGATTCGGTGGTCTTGTCTTTTTTTTTAGTGCTCCTAATTTTAGGAAACTTACTGTTTTCCGGAATTGGCTCGATTACTACATCTTCTCGTGCGGTATATAGTTTTAGTCGTGACCAGGCTATACCATACTACGATAAATGGACCTACGTCGAACCGGATTCTCAGTCAAAAGTCCCCAAGAATTCTGTTGTATTGAGTATGATAATATCATACTTTTTAGGTCTGCTAGCTTTGATTTCAACGGCCGCATTTAATGCTTTTATAGGCGCTGCAGTGCTCTGTCTTTGTTCTGCGACTTTCATTCCGTTAGTCTTGGTGCTGTTTACGAGAAGAAGAGCTATCCGAAGCGCGCCAGTAAAAATCAGGTATAAGTTTGGTTGGTTCATCAACATTGTTTCTATTGTGTGGCTCTTGTTATCTATGGTTTCTGTTTGCCTACCAACGCAAGTGCCTGTAACTTTCAAAACAATGAATTATGCTTTAATGGTGTACGTATTCTGCATTTTAGTTATCACTGGTCTTTATTTCAAATGGGGGAAGTATAATTTTAGATTACCCTTGGCAGATGACATCAAGGCTCCAATTCCCAGTGATGCGGAAGAAACTGTTTTTGAACTAGAGGATAGCAATGTTGAACATACTCTAAACTCGGGAACCACAGTGAAAGAGTCTGTAGAAAATAATTCTGAAGAAGGTTTCATCAAGGTGCATCCTAAAAGTAGTACAGAAAATCCCTTTGAGGAAAATGAGGAAAACGTGATAACCGATTATGGTGATGAGCACCATACAGCAGAACAAGAATTTGATCTTGCCGATGATCGTAGATATGATATATGA","protein_sequence":"MPEYTLLADNIRENIVHFDPNGLFDNLHTIVHEDDSQENEEAEHFNYDQVLDKSLLSRGSIVGLGLGLMSPVLGMCTSMAIGLINGGPLTIMLGFLISGVCIWFSSLSLGEIVSKFPMELHVGSAMLAPEKLKLVCSWYTGWLMLIGNWTMSTSITFAGAQLTISLILMTNSNLISEAHLIFYTVIVFYLVVTVVGLVNLKFARFIETINKVCVYWIIYAIIFIDILLLVFHKGKFRSLKYALFHFDNNLSGYKSAFLSFIIGFQQSNFTLQGFSMLPALADEVKVPEKDIPRGMSNAVLLSAFSGVIFLIPIMLILPDNDLLFTNHKVLPIVNIFTKSTDSVVLSFFLVLLILGNLLFSGIGSITTSSRAVYSFSRDQAIPYYDKWTYVEPDSQSKVPKNSVVLSMIISYFLGLLALISTAAFNAFIGAAVLCLCSATFIPLVLVLFTRRRAIRSAPVKIRYKFGWFINIVSIVWLLLSMVSVCLPTQVPVTFKTMNYALMVYVFCILVITGLYFKWGKYNFRLPLADDIKAPIPSDAEETVFELEDSNVEHTLNSGTTVKESVENNSEEGFIKVHPKSSTENPFEENEENVITDYGDEHHTAEQEFDLADDRRYDI"},{"created_at":"2011-05-27T02:21:37.000Z","updated_at":"2011-05-27T15:01:17.000Z","name":"Polyamine transporter 1","uniprot_id":"Q07824","uniprot_name":"TPO1_YEAST","enzyme":false,"transporter":true,"gene_name":"TPO1","num_residues":586,"molecular_weight":"64271.60156","theoretical_pi":"6.88","general_function":"Involved in transmembrane transport","specific_function":"Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Catalyzes polyamine uptake at alkaline pH and excretion at acidic pH. Recognizes spermidine, spermine and putrescine, the polyamine analogs methylglyoxal bis(guanylhydrazone) (MGBG) and paraquat, the antimalarial drug quinidine, and cycloheximide. Confers resistance to the non-steroidal anti-inflammatory drug indomethacin","reactions":[],"signal_regions":"None","transmembrane_regions":"146-166;182-202;213-233;243-263;272-292;302-322;377-397;415-435;455-475;484-504;506-526;529-549;550-570","pdb_id":null,"cellular_location":"Cell membrane; Multi-pass membrane protein.","genbank_gene_id":"Z73133","genbank_protein_id":"1360210","gene_card_id":"TPO1","chromosome_location":"chromosome 12","locus":"YLL028W","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" drug transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"},{"category":"Process","description":" drug transport"}],"pfams":[{"name":"MFS_1","identifier":"PF07690"}],"pathways":[],"gene_sequence":"ATGTCGGATCATTCTCCCATTTCTAATAAGGAAAATCATCTGCTGCCATCAGACTCGTCAAGAAGCTCATCCAGCGATATGCATTCGACGGGCACCACGGGAACCACAGGCGTCGAACCTGTAGATTTCACCGGTGAAGGTGCCAAATACACAACTGCTACGGAGGGCAATGGTGGTGCAGATTTAGCGATTCAAAGAACGACGACTATGAATTCTGCTGCAGAATCAGAGGTTAATATCACGAGAAGATTAACTAAAATCCTTACTGGGTCTGTTAACGAGCCTGACCGTGTAGAGGTTGATTATACCAATTGTGCGCCCATGGGTGGTGACAGACCTTACCCTCCATCGTTGCCGAGCAGAGACCTGTACGAGGTTACTTTTGATGGTCCTAACGACCCACTACATCCATTTAACTGGCCCATGAAGAAGAAAGTGCTGCTATGTCTGGTCTTATGTCTGGATTCTATTGCCATTGCTATGTGTTCTTCCATTTTTGCCTCTGCAGTGCCGCAAATCTGCGAGATATACCACGTCATCGAAGTTGTCGCCATTTTGGGTATCACGCTTTTTGTTCTTGGGTTTGCGGCCTCACCGGTTATCTATGCTCCTCTTTCTGAATTGTACGGTAGAAAGGGTGTTCTGGTTTTATCTGCGTTTGGATTTGCCCTTTTCCAATTTGCTGTCGCTACTGCTGAGAACCTGCAAACTATTTTCATATGTAGATTCTTTGGTGGTTTTATCGGGGCAGCACCCATGGCCGTCGTCCCCGCCGCGTTTGCCGACATGTTTGATACTAATGTTAGAGGTAAAGCCATTGCGCTATTTTCTCTAGGTGTTTTTGTAGGCCCCATTTTATCGCCTGTCATGGGTTCTTATATCGCACAAAGAACTACCTGGAGATGGTTAGAATATGTTGTCGGTTGTTTCGCTTCCGCAGTTTTCGTTGCCATCGTATTGTTCTTTGAAGAAACACATCACCCTACCATTTTGGTTAACAAGGCCAAACAGATGAGAAAGCAAAGTAATAACTGGGGTATTCATGCTGCTCATGAAGACGTGGAGCTATCCATCAAAGACATTGTCCAAAAAACTGTGACGAGGCCTATCATTATGCTTTTCGTGGAACCATTGCTACTATTCGTGACTATTTACAACTCTTTTGTCTACGGTATCTTGTATTTGTTACTGGAAGCCTACCCACTTGTCTTTGTGGAGGGTTATGGGTTTACTGAAAACGGTGAGTTGCCATACATCGCCTTGATTATCGGTATGATGGTGTGTGCTGCTTTCATTTGGTATATGGACAACGATTATTTGAAAAGATGTAGAGCCAAGGGGAAATTAGTGCCCGAGGCCAGATTGTACGCAATGGTCATTGCAGGTACCGTTTTCCCTATTGGTATCTTATGGTTCTGTTGGACGGGCTACTATCCTCACAAGATTCATTGGATGGTCCCCACAGTAGGAGGGGCCTTCATCGGGTTCGGTTTAATGGGTATTTTCTTGCCATGTTTAAACTATATCATTGAATCGTATCTATTGTTGGCAGCTTCTGCCGTCGCAGCAAACACTTTCATGAGGTCTGCATTTGGTGCATGCTTCCCATTGTTTGCAGGATATATGTTCCGTGGCATGGGTATCGGTTGGGCTGGTTTGTTATTAGGTCTATTTGCCGCTGCGATGATTCCCGTGCCTTTACTATTCTTAAAATATGGTGAATCTATCAGAAAGAAATCCAAGTATGCTTACGCCGCTTAA","protein_sequence":"MSDHSPISNKENHLLPSDSSRSSSSDMHSTGTTGTTGVEPVDFTGEGAKYTTATEGNGGADLAIQRTTTMNSAAESEVNITRRLTKILTGSVNEPDRVEVDYTNCAPMGGDRPYPPSLPSRDLYEVTFDGPNDPLHPFNWPMKKKVLLCLVLCLDSIAIAMCSSIFASAVPQICEIYHVIEVVAILGITLFVLGFAASPVIYAPLSELYGRKGVLVLSAFGFALFQFAVATAENLQTIFICRFFGGFIGAAPMAVVPAAFADMFDTNVRGKAIALFSLGVFVGPILSPVMGSYIAQRTTWRWLEYVVGCFASAVFVAIVLFFEETHHPTILVNKAKQMRKQSNNWGIHAAHEDVELSIKDIVQKTVTRPIIMLFVEPLLLFVTIYNSFVYGILYLLLEAYPLVFVEGYGFTENGELPYIALIIGMMVCAAFIWYMDNDYLKRCRAKGKLVPEARLYAMVIAGTVFPIGILWFCWTGYYPHKIHWMVPTVGGAFIGFGLMGIFLPCLNYIIESYLLLAASAVAANTFMRSAFGACFPLFAGYMFRGMGIGWAGLLLGLFAAAMIPVPLLFLKYGESIRKKSKYAYAA"},{"created_at":"2011-05-27T05:23:00.000Z","updated_at":"2011-05-27T15:01:24.000Z","name":"S-adenosylmethionine permease SAM3","uniprot_id":"Q08986","uniprot_name":"SAM3_YEAST","enzyme":false,"transporter":true,"gene_name":"SAM3","num_residues":587,"molecular_weight":"64353.0","theoretical_pi":"7.88","general_function":"Involved in transport","specific_function":"High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source","reactions":[],"signal_regions":"None","transmembrane_regions":"81-103;110-129;163-183;187-207;220-240;267-287;303-323;361-381;407-427;432-452;476-496;510-530","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein. Endoplasmic reticulum","genbank_gene_id":"Z73630","genbank_protein_id":"1370565","gene_card_id":"SAM3","chromosome_location":"chromosome 16","locus":"YPL274W","synonyms":["S-adenosylmethionine metabolism protein 3"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGGATATACTCAAGAGGGGAAATGAATCGGACAAGTTTACGAAAATAGAGACAGAATCTACTACGATACCAAATGACTCGGATAGATCTGGTTCACTGATCAGAAGAATGAAGGATTCCTTCAAGCAAAGTAACCTGCATGTCATTCCAGAAGACCTTGAAAACAGCGAACAGACAGAGCAGGAAAAAATCCAATGGAAACTAGCTTCTCAGCCCTATCAAAAAGTCTTGAGCCAAAGGCACTTGACCATGATTGCCATAGGTGGTACTTTGGGGACGGGACTGTTCATTGGTTTAGGTTATTCTTTGGCATCTGGGCCAGCCGCTTTGCTAATCGGTTTTTTGTTAGTTGGTACTTCAATGTTCTGTGTCGTTCAGAGTGCCGCAGAGCTTTCCTGCCAATTCCCGGTTTCTGGCTCATATGCCACACATGTCAGTAGGTTCATAGATGAATCGGTTGGCTTTACTGTGGCTACAAACTATGCTTTGGCTTGGCTGATTTCTTTTCCAAGCGAATTAATTGGTTGTGCACTTACTATTTCATACTGGAACCAAACGGTTAATCCGGCTGTTTGGGTGGCCATTTTTTATGTTTTCATTATGGTACTGAACTTGTTTGGTGTGAGAGGCTTTGCCGAGACTGAGTTTGCTCTGTCAATCATTAAGGTTATTGCTATATTTATTTTCATCATTATTGGTATCGTCCTTATTGCCGGAGGGGGGCCTAACTCTACTGGTTATATTGGCGCCAAATACTGGCACGACCCAGGTGCCTTCGCAAAACCTGTCTTCAAGAATTTGTGTAACACATTCGTTTCTGCTGCTTTTTCCTTTGGTGGTAGTGAGTTAGTGCTGTTAACTAGTACAGAATCTAAAAATATTTCAGCTATATCACGTGCTGCCAAAGGTACGTTCTGGAGAATCGCGATTTTTTACATTACTACCGTTGTCATTATTGGATGTCTCGTACCTTATAACGACCCCAGACTGCTCAGTGGTTCGAACAGTGAGGATGTATCTGCCTCTCCCTTTGTTATTGCTTTGAGTAATACAGGATCAATGGGTGCAAAAGTTTCCAACTTTATGAATGTCGTTATCCTTGTTGCGGTTGTGTCAGTTTGCAATTCTTGCGTTTATGCTTCTTCAAGACTAATTCAAGCTTTAGGTGCATCTGGCCAACTTCCTTCGGTATGTTCCTACATGGACAGAAAGGGTAGGCCTTTGGTTGGCATTGGGATTAGTGGTGCATTTGGTCTTTTAGGTTTTCTTGTGGCCTCGAAAAAGGAGGACGAGGTCTTCACTTGGCTTTTCGCCCTTTGTTCCATTTCATCATTCTTCACCTGGTTCTGTATTTGTATGTCACAAATTAGATTTAGGATGGCTTTGAAAGCTCAAGGAAGATCCAATGACGAAATAGCTTACAAATCCATACTGGGTGTTTATGGTGGAATTTTGGGGTGTGTGCTAAATGCATTGCTAATTGCGGGTGAAATATACGTATCGGCCGCCCCGGTCGGTAGCCCTAGCTCCGCTGAAGCCTTCTTTGAATACTGTTTAAGTATTCCAATCATGATTGTTGTTTATTTTGCACATAGGTTTTATCGAAGAGATTGGAAACACTTCTACATCAAGAGGAGTGAGATCGATCTGGATACTGGGTGTTCCGTGGAGAATCTAGAGCTTTTCAAAGCACAAAAAGAAGCTGAGGAACAACTCATTGCTTCTAAGCCATTCTATTACAAAATCTACAGATTTTGGTGTTAG","protein_sequence":"MDILKRGNESDKFTKIETESTTIPNDSDRSGSLIRRMKDSFKQSNLHVIPEDLENSEQTEQEKIQWKLASQPYQKVLSQRHLTMIAIGGTLGTGLFIGLGYSLASGPAALLIGFLLVGTSMFCVVQSAAELSCQFPVSGSYATHVSRFIDESVGFTVATNYALAWLISFPSELIGCALTISYWNQTVNPAVWVAIFYVFIMVLNLFGVRGFAETEFALSIIKVIAIFIFIIIGIVLIAGGGPNSTGYIGAKYWHDPGAFAKPVFKNLCNTFVSAAFSFGGSELVLLTSTESKNISAISRAAKGTFWRIAIFYITTVVIIGCLVPYNDPRLLSGSNSEDVSASPFVIALSNTGSMGAKVSNFMNVVILVAVVSVCNSCVYASSRLIQALGASGQLPSVCSYMDRKGRPLVGIGISGAFGLLGFLVASKKEDEVFTWLFALCSISSFFTWFCICMSQIRFRMALKAQGRSNDEIAYKSILGVYGGILGCVLNALLIAGEIYVSAAPVGSPSSAEAFFEYCLSIPIMIVVYFAHRFYRRDWKHFYIKRSEIDLDTGCSVENLELFKAQKEAEEQLIASKPFYYKIYRFWC"},{"created_at":"2011-05-27T05:23:40.000Z","updated_at":"2011-05-27T15:01:24.000Z","name":"General amino acid permease AGP2","uniprot_id":"P38090","uniprot_name":"AGP2_YEAST","enzyme":false,"transporter":true,"gene_name":"AGP2","num_residues":596,"molecular_weight":"67261.29688","theoretical_pi":"7.22","general_function":"Involved in transport","specific_function":"General amino acid permease with broad substrate specificity. Can also transport carnitine","reactions":[],"signal_regions":"None","transmembrane_regions":"95-115;118-138;166-186;200-220;228-248;289-309;327-347;380-400;428-448;460-480;506-526;535-555","pdb_id":null,"cellular_location":"Membrane; Multi-pass membrane protein","genbank_gene_id":"X75891","genbank_protein_id":"496863","gene_card_id":"AGP2","chromosome_location":"chromosome 2","locus":"YBR132C","synonyms":[],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" active transmembrane transporter activity"},{"category":"Function","description":" amine transmembrane transporter activity"},{"category":"Function","description":" amino acid transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Process","description":" amine transport"},{"category":"Process","description":" amino acid transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"AA_permease","identifier":"PF00324"}],"pathways":[],"gene_sequence":"ATGACAAAGGAACGTATGACCATCGACTACGAAAATGACGGTGATTTTGAGTACGATAAGAATAAATACAAGACAATAACCACTCGAATAAAGAGTATCGAACCTAGTGAGGGATGGTTGGAACCTTCTGGGTCAGTGGGTCACATAAACACGATACCCGAAGCGGGCGATGTTCACGTGGATGAACATGAGGATAGAGGGTCTTCTATTGATGATGACTCAAGGACTTACCTGCTATATTTCACAGAAACTCGACGTAAACTAGAAAACAGGCACGTCCAGTTGATTGCTATTTCCGGTGTCATTGGTACGGCGCTATTCGTGGCGATCGGAAAAGCTTTATACCGTGGAGGGCCCGCCTCTTTATTATTGGCATTTGCTCTTTGGTGTGTTCCAATACTTTGCATTACTGTGTCTACAGCGGAAATGGTCTGCTTTTTCCCTGTAAGTTCCCCCTTTTTGAGATTAGCAACGAAGTGCGTTGACGATTCATTGGCTGTCATGGCTAGCTGGAATTTCTGGTTTCTTGAATGCGTACAGATCCCTTTCGAGATTGTTTCTGTTAATACAATTATACATTATTGGAGAGATGATTATTCAGCTGGTATTCCGCTCGCCGTTCAAGTAGTTTTGTATCTGCTTATTTCCATTTGTGCAGTCAAATATTACGGTGAAATGGAATTTTGGTTGGCTTCTTTCAAAATTATCCTTGCACTCGGCCTATTTACATTCACGTTCATTACCATGTTGGGTGGAAATCCTGAACATGATCGTTACGGGTTTCGTAATTATGGTGAAAGTCCATTCAAGAAATACTTTCCCGATGGCAATGATGTGGGGAAGTCTTCGGGCTACTTCCAGGGGTTTCTCGCTTGCTTGATTCAGGCATCGTTTACCATAGCTGGTGGCGAGTATATTTCTATGTTAGCGGGAGAGGTCAAACGACCAAGAAAAGTATTACCCAAGGCGTTTAAGCAGGTGTTTGTGAGATTAACATTTTTGTTTTTAGGGAGTTGTCTGTGTGTTGGGATTGTTTGTTCGCCAAATGATCCTGACTTGACAGCAGCAATTAATGAAGCAAGGCCTGGCGCCGGGTCTTCACCTTATGTCATTGCAATGAATAATCTGAAAATTAGAATATTACCTGACATTGTTAATATAGCTTTGATTACAGCCGCCTTTTCTGCTGGTAACGCTTACACTTATTGCTCATCCAGAACATTTTATGGTATGGCATTAGATGGCTACGCGCCAAAAATCTTCACTAGATGCAATAGGCATGGTGTGCCCATTTACTCTGTGGCCATATCTTTGGTATGGGCTTTAGTGAGCCTTTTGCAACTGAATTCTAATAGTGCGGTCGTATTGAATTGGTTAATTAACTTGATTACTGCCTCTCAATTGATTAATTTTGTCGTCCTTTGTATCGTCTATTTATTTTTCAGAAGGGCTTACCACGTCCAACAAGATTCGTTACCCAAGTTGCCATTCCGTTCGTGGGGTCAACCATACACTGCTATTATCGGCCTTGTTTCATGTTCCGCAATGATTTTAATACAGGGCTACACCGTTTTCTTTCCCAAATTATGGAACACACAAGATTTTTTGTTTTCGTATTTAATGGTGTTTATCAACATCGGTATATATGTGGGCTACAAATTTATTTGGAAACGTGGTAAAGATCACTTCAAAAACCCACATGAAATTGACTTTTCTAAAGAGCTAACAGAAATTGAAAACCATGAGATTGAAAGCTCCTTCGAAAAATTTCAATATTATAGCAAAGCATAA","protein_sequence":"MTKERMTIDYENDGDFEYDKNKYKTITTRIKSIEPSEGWLEPSGSVGHINTIPEAGDVHVDEHEDRGSSIDDDSRTYLLYFTETRRKLENRHVQLIAISGVIGTALFVAIGKALYRGGPASLLLAFALWCVPILCITVSTAEMVCFFPVSSPFLRLATKCVDDSLAVMASWNFWFLECVQIPFEIVSVNTIIHYWRDDYSAGIPLAVQVVLYLLISICAVKYYGEMEFWLASFKIILALGLFTFTFITMLGGNPEHDRYGFRNYGESPFKKYFPDGNDVGKSSGYFQGFLACLIQASFTIAGGEYISMLAGEVKRPRKVLPKAFKQVFVRLTFLFLGSCLCVGIVCSPNDPDLTAAINEARPGAGSSPYVIAMNNLKIRILPDIVNIALITAAFSAGNAYTYCSSRTFYGMALDGYAPKIFTRCNRHGVPIYSVAISLVWALVSLLQLNSNSAVVLNWLINLITASQLINFVVLCIVYLFFRRAYHVQQDSLPKLPFRSWGQPYTAIIGLVSCSAMILIQGYTVFFPKLWNTQDFLFSYLMVFINIGIYVGYKFIWKRGKDHFKNPHEIDFSKELTEIENHEIESSFEKFQYYSKA"}]}